POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HLO_A_GBQA1501_0
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		2ksb SUBSTANCE-P RECEPTOR
(Homo
sapiens)		6 / 12TYR A 196
THR A 201
TRP A 261
PHE A 264
HIS A 265
MET A 295
None
1.05A62.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		2j0u ATP-DEPENDENT RNA
HELICASE DDX48
(Homo
sapiens)		5 / 9ILE A 237
ILE A  79
GLN A  71
GLU A 317
MET A 183
None
1.27A21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		2lg1 A-KINASE ANCHOR
PROTEIN 13
(Homo
sapiens)		5 / 9ILE A 164
ILE A 166
GLU A 151
VAL A 127
ILE A 167
None
1.40A18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		2n03 PLECTIN
(Homo
sapiens)		5 / 9ASN A4442
ILE A4486
VAL A4469
ILE A4458
MET A4435
None
1.43A17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		3h2x TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 22
(Homo
sapiens)		5 / 9ILE A 205
GLU A 277
VAL A 236
ILE A 237
MET A 130
None
None
None
None
PO4  A 901 (-4.0A)
1.18A20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens)		5 / 9ASN A 528
ILE A 458
ILE A 456
GLU A 476
ILE A 455
None
1.11A21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		4v2a NETRIN RECEPTOR
UNC5A
(Homo
sapiens)		5 / 9ILE A 142
ILE A 144
GLU A  51
VAL A  61
ILE A  55
None
1.35A19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		4ybh ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR
(Homo
sapiens)		5 / 9ILE A 318
ILE A 320
GLU A 245
VAL A 255
ILE A 291
None
1.44A18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		1ko6 NUCLEAR PORE COMPLEX
PROTEIN NUP98
(Homo
sapiens)		5 / 12ASN A 765
VAL A 775
ILE A 744
THR A 749
ILE A 750
None
1.45A17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		2d7i POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 10
(Homo
sapiens)		5 / 12ASN A 245
PRO A 173
VAL A 177
THR A 234
ILE A 149
None
1.43A20.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		2ksb SUBSTANCE-P RECEPTOR
(Homo
sapiens)		5 / 12TYR A 196
THR A 201
ILE A 204
HIS A 265
MET A 295
None
0.90A74.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		2ksb SUBSTANCE-P RECEPTOR
(Homo
sapiens)		5 / 12VAL A 116
TYR A 196
THR A 201
PHE A 264
HIS A 265
None
0.96A74.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		2oz4 INTERCELLULAR
ADHESION MOLECULE 1
FAB FRAGMENT, HEAVY
CHAIN
(Homo
sapiens;
Mus
musculus)		5 / 12ASN A 397
PRO A 400
THR H  53
ILE H  54
PHE H  32
None
1.28A21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		3fay RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP1
(Homo
sapiens)		5 / 12ASN A1197
ILE A1200
ILE A1156
PHE A1266
PHE A1262
None
1.41A22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		3qye TBC1 DOMAIN FAMILY
MEMBER 1
(Homo
sapiens)		5 / 12ILE A1050
THR A1041
ILE A1042
PHE A 974
MET A 973
None
1.33A19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		4or2 SOLUBLE CYTOCHROME
B562, METABOTROPIC
GLUTAMATE RECEPTOR 1
(Escherichia
coli;
Homo
sapiens)		5 / 12VAL A 622
ILE A 787
ILE A 837
PHE A 614
PHE A 831
None
1.29A21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		5mkf POLYCYSTIN-2
(Homo
sapiens)		5 / 12PRO A 453
VAL A 451
TYR A 386
THR A 419
PHE A 279
None
1.38A16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		5ufl PROTEIN CIP2A
(Homo
sapiens)		5 / 12ILE A 393
ILE A 374
PHE A 321
PHE A 385
MET A 320
None
1.07A21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		6caa ELECTROGENIC SODIUM
BICARBONATE
COTRANSPORTER 1
(Homo
sapiens)		5 / 12PRO A 712
ILE A 852
TYR A 433
THR A 438
ILE A 441
None
1.36Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		1bjx PROTEIN DISULFIDE
ISOMERASE
(Homo
sapiens)		4 / 7ILE A 212
GLN A 216
GLU A 137
VAL A 140
None
1.12A14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		1x4g NUCLEOLYSIN TIAR
(Homo
sapiens)		4 / 7ILE A  78
GLU A  72
HIS A  71
VAL A  17
None
1.19A13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		2coy DYNACTIN-1
(Homo
sapiens)		4 / 7ILE A  94
GLU A  41
VAL A  67
TRP A  64
None
0.90A13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		2lmi G-RICH SEQUENCE
FACTOR 1
(Homo
sapiens)		4 / 7ILE A  14
GLU A  73
HIS A  75
VAL A  86
None
1.19A12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		3iu1 GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 1
(Homo
sapiens)		4 / 7ILE A 381
GLN A 378
GLU A 372
HIS A 373
None
0.96A21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens)		4 / 7ILE A 276
GLU A 224
HIS A 222
VAL A 202
None
1.07A19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC
(Homo
sapiens)		4 / 7ILE A 155
GLU A 141
HIS A 143
VAL A 135
None
1.06A20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		4bd3 PHD FINGER PROTEIN
19
(Homo
sapiens)		4 / 7ILE A  87
GLU A  42
VAL A  46
TRP A  50
None
1.13A8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		4dx2 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 4
(Homo
sapiens)		4 / 7ILE A 300
GLN A 297
GLU A 247
VAL A 254
None
1.07A19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens)		4 / 7ILE A 501
TRP A 561
HIS A 559
VAL A 493
None
1.17A18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		4oya ADENYLATE CYCLASE
TYPE 10
(Homo
sapiens)		4 / 7ILE A  82
GLU A 131
HIS A 127
VAL A 143
None
1.08A21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		5avi OXYSTEROLS RECEPTOR
LXR-ALPHA
(Homo
sapiens)		4 / 7ILE A 360
GLN A 221
GLU A 267
VAL A 297
None
1.17A18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens)		4 / 7ILE A 403
GLU A 385
VAL A 430
TRP A 365
None
1.09A19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens)		4 / 7ILE A1068
GLN A1170
GLU A1171
VAL A1073
None
None
PRO  A1602 ( 4.7A)
None
1.18A21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens)		5 / 12ASN A 483
PRO A 454
ILE A 471
VAL A 456
PHE A 487
None
1.22A18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens)		5 / 12ASN A 707
ASN A 509
ILE A 128
ILE A 507
PHE A 154
None
None
None
SF4  A1000 ( 3.8A)
None
1.25A19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		3dkp PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX52
(Homo
sapiens)		5 / 12ASN A 370
ILE A 372
VAL A 151
HIS A 201
VAL A 198
None
1.18A19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		4dyo ASPARTYL
AMINOPEPTIDASE
(Homo
sapiens)		5 / 12ILE A 337
HIS A 291
VAL A 292
PHE A 461
PHE A 465
None
1.35A20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE
(Homo
sapiens)		5 / 12ASN B1692
PRO B1520
ILE B1331
VAL B1518
ILE B1358
None
1.41A12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		4tns PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
NIMA-INTERACTING 1
(Homo
sapiens)		5 / 12ASN A  90
ILE A  93
VAL A  62
HIS A  64
PHE A 151
None
1.45A13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		5m8i CUGBP ELAV-LIKE
FAMILY MEMBER 2
(Homo
sapiens)		5 / 12ILE A  33
VAL A  75
ILE A  95
VAL A 102
PHE A  52
None
1.29A12.76