POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ENH_A_FVXA602_1 (CHOLESTEROL 24-HYDROXYLASE)	1zef	ALKALINE PHOSPHATASE (Homo sapiens)	5 / 12	LEU A  69 ALA A  51 THR A  48 ALA A 327 THR A 331	None	1.12A	23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ENH_A_FVXA602_1 (CHOLESTEROL 24-HYDROXYLASE)	2can	ORNITHINE AMINOTRANSFERASE (Homo sapiens)	5 / 12	LEU A 402 ILE A 432 ALA A 390 GLY A 409 ALA A 404	None	1.01A	21.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4ENH_A_FVXA602_1 (CHOLESTEROL 24-HYDROXYLASE)	2q9g	CYTOCHROME P450 46A1 (Homo sapiens)	12 / 12	PHE A  80 PHE A 121 LEU A 219 ILE A 222 ILE A 301 ALA A 302 THR A 306 ALA A 367 TRP A 368 GLY A 369 ALA A 474 THR A 475	None None None None None HEM  A 505 (-3.7A) HEM  A 505 (-3.7A) HEM  A 505 (-3.5A) None None None None	0.38A	100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ENH_A_FVXA602_1 (CHOLESTEROL 24-HYDROXYLASE)	3gcw	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (Homo sapiens)	5 / 12	LEU A 415 ALA A 393 ALA A 388 GLY A 365 ALA A 442	None	1.16A	20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ENH_A_FVXA602_1 (CHOLESTEROL 24-HYDROXYLASE)	4ov6	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (Homo sapiens)	5 / 12	LEU B 415 ALA B 393 ALA B 388 GLY B 365 ALA B 442	None	1.11A	19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ENH_A_FVXA602_1 (CHOLESTEROL 24-HYDROXYLASE)	5fbh	EXTRACELLULAR CALCIUM-SENSING RECEPTOR (Homo sapiens)	5 / 12	PHE B 183 ILE B 187 GLY B 148 ALA B 168 THR B 145	None None None TCR  B 609 (-4.1A) CL  B 605 ( 3.9A)	1.13A	20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ENH_A_FVXA602_1 (CHOLESTEROL 24-HYDROXYLASE)	5kca	CEREBELLIN-1,CEREBEL LIN-1,CEREBELLIN-1,G LUTAMATE RECEPTOR IONOTROPIC, DELTA-2 (Homo sapiens)	5 / 12	LEU A 455 ILE A 368 ILE A 411 ALA A 427 GLY A 440	None	1.10A	18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MM9_A_FVXA603_1 (TRANSPORTER)	2o6l	UDP-GLUCURONOSYLTRAN SFERASE 2B7 (Homo sapiens)	5 / 11	ASP A 435 VAL A 413 ALA A 412 SER A 437 GLY A 410	None	1.27A	14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MM9_A_FVXA603_1 (TRANSPORTER)	3lmk	METABOTROPIC GLUTAMATE RECEPTOR 5 (Homo sapiens)	5 / 11	ASP A 178 ALA A 196 GLY A 224 SER A 176 ASP A 233	None	1.24A	20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MM9_A_FVXA603_1 (TRANSPORTER)	5epg	ALDEHYDE OXIDASE (Homo sapiens)	5 / 11	ASP A1093 VAL A1163 TYR A1161 SER A1265 GLY A1192	None	1.00A	17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MM9_A_FVXA603_1 (TRANSPORTER)	5gwn	PROTEIN RCC2 (Homo sapiens)	5 / 11	VAL A 478 TYR A 464 GLY A 110 PHE A 109 GLY A 465	None	1.30A	21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MM9_A_FVXA603_1 (TRANSPORTER)	5hcc	COMPLEMENT C5 (Homo sapiens)	5 / 11	VAL A1423 ALA A1422 TYR A1496 TYR A1498 SER A1007	None	1.27A	19.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4MM9_A_FVXA603_1 (TRANSPORTER)	5i6z	SODIUM-DEPENDENT SEROTONIN TRANSPORTER (Homo sapiens)	6 / 11	TYR A  95 ASP A  98 ALA A 169 GLY A 338 SER A 438 GLY A 442	None	1.44A	32.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4MM9_A_FVXA603_1 (TRANSPORTER)	5i6z	SODIUM-DEPENDENT SEROTONIN TRANSPORTER (Homo sapiens)	8 / 11	TYR A  95 ASP A  98 ALA A 173 TYR A 175 TYR A 176 GLY A 338 SER A 438 GLY A 442	None	0.68A	32.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MM9_A_FVXA603_1 (TRANSPORTER)	6f39	COMPLEMENT C1R SUBCOMPONENT (Homo sapiens)	5 / 11	ASP A 226 TYR A 197 GLY A 252 PHE A 223 SER A 278	CA  A 303 (-3.2A) None None None CA  A 303 ( 3.8A)	1.14A	8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AWP_A_FVXA701_1 (SODIUM-DEPENDENT SEROTONIN TRANSPORTER)	1fq3	GRANZYME B (Homo sapiens)	5 / 9	ASN A  98 SER A 100 SER A 214 SER A 195 GLY A 196	None None None SO4  A 800 (-2.4A) None	1.39A	16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AWP_A_FVXA701_1 (SODIUM-DEPENDENT SEROTONIN TRANSPORTER)	1ivh	ISOVALERYL-COA DEHYDROGENASE (Homo sapiens)	5 / 9	ASN A 169 SER A  96 SER A 126 GLY A  56 THR A  64	None	1.37A	21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AWP_A_FVXA701_1 (SODIUM-DEPENDENT SEROTONIN TRANSPORTER)	2akz	GAMMA ENOLASE (Homo sapiens)	5 / 9	ASN A 101 ILE A  72 SER A 103 GLY A 112 THR A  71	None	1.50A	23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AWP_A_FVXA701_1 (SODIUM-DEPENDENT SEROTONIN TRANSPORTER)	2f57	SERINE/THREONINE-PRO TEIN KINASE PAK 7 (Homo sapiens)	5 / 9	ASN A 505 ILE A 626 PHE A 676 SER A 628 GLY A 630	None	1.39A	20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AWP_A_FVXA701_1 (SODIUM-DEPENDENT SEROTONIN TRANSPORTER)	2iwg	52 KDA RO PROTEIN (Homo sapiens)	5 / 9	SER B 151 PHE B 155 SER B  90 SER B  92 GLY B  93	None	1.47A	14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AWP_A_FVXA701_1 (SODIUM-DEPENDENT SEROTONIN TRANSPORTER)	2vn8	RETICULON-4-INTERACT ING PROTEIN 1 (Homo sapiens)	5 / 9	ASP A  87 ASN A  84 ILE A  48 SER A  92 GLY A  93	None	1.38A	21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AWP_A_FVXA701_1 (SODIUM-DEPENDENT SEROTONIN TRANSPORTER)	3eab	CHMP1B SPASTIN (Homo sapiens)	5 / 9	ASP G 186 SER G 189 PHE A 124 SER G 182 SER G 179	None	1.50A	6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AWP_A_FVXA701_1 (SODIUM-DEPENDENT SEROTONIN TRANSPORTER)	3hng	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 1 (Homo sapiens)	5 / 9	ASN A1034 SER A1001 PHE A1093 SER A 918 GLY A1096	None	1.39A	20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AWP_A_FVXA701_1 (SODIUM-DEPENDENT SEROTONIN TRANSPORTER)	5f89	CAP248-2B HEAVY CHAIN CAP248-2B LIGHT CHAIN (Homo sapiens)	5 / 9	SER L 177 SER H 179 SER H 180 GLY H 139 THR L 115	None	1.39A	17.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6AWP_A_FVXA701_1 (SODIUM-DEPENDENT SEROTONIN TRANSPORTER)	5i6z	SODIUM-DEPENDENT SEROTONIN TRANSPORTER (Homo sapiens)	8 / 9	ASP A  98 ASN A 101 ILE A 172 SER A 336 SER A 438 SER A 439 GLY A 442 THR A 497	None	0.46A	99.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AWP_A_FVXA701_1 (SODIUM-DEPENDENT SEROTONIN TRANSPORTER)	6b3x	CLEAVAGE STIMULATION FACTOR SUBUNIT 1 (Homo sapiens)	5 / 9	ASN A 269 ILE A 123 SER A 406 GLY A 120 THR A 125	None	1.42A	21.96