POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		1jd0 CARBONIC ANHYDRASE
XII
(Homo
sapiens)		9 / 12GLN A  92
HIS A  94
HIS A  96
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
AZM  A1400 (-3.2A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.2A)
AZM  A1400 (-4.6A)
AZM  A1400 ( 4.9A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
AZM  A1400 (-3.3A)
None
0.42A36.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		1jd0 CARBONIC ANHYDRASE
XII
(Homo
sapiens)		5 / 12HIS A  96
LEU A 198
THR A 199
THR A 200
TRP A 209
 ZN  A 901 ( 3.2A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
AZM  A1400 (-3.3A)
None
1.14A36.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens)		8 / 12HIS A  64
GLN A  92
HIS A  94
HIS A  96
VAL A 143
LEU A 198
THR A 199
TRP A 209
None
None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
0.65A60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens)		5 / 12HIS A  64
PHE A  91
LEU A 198
THR A 199
TRP A 209
None
None
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
0.77A60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens)		5 / 12HIS A  96
HIS A 107
PHE A  91
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
None
None
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
0.88A60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		2w2j CARBONIC
ANHYDRASE-RELATED
PROTEIN
(Homo
sapiens)		5 / 12HIS A 118
VAL A 157
LEU A 222
THR A 223
TRP A 233
 CL  A 401 (-4.2A)
None
None
CL  A 401 ( 4.8A)
None
0.70A38.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		3c49 POLY(ADP-RIBOSE)
POLYMERASE 3
(Homo
sapiens)		5 / 12VAL A 361
PHE A 440
VAL A 391
LEU A 192
THR A 189
None
1.07A18.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		5 / 12GLN A  93
HIS A  95
HIS A  97
LEU A 199
THR A 200
4MD  A 401 (-3.1A)
ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.5A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
0.94A59.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		5 / 12GLN A  93
HIS A  97
PHE A 132
LEU A 199
THR A 200
4MD  A 401 (-3.1A)
ZN  A 301 ( 3.5A)
4MD  A 401 (-4.6A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
0.86A59.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		7 / 12HIS A  95
HIS A  97
VAL A 122
VAL A 144
LEU A 199
THR A 200
TRP A 210
 ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.5A)
4MD  A 401 ( 4.6A)
4MD  A 401 ( 4.4A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
None
0.52A59.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		7 / 12HIS A  97
VAL A 122
PHE A 132
VAL A 144
LEU A 199
THR A 200
TRP A 210
 ZN  A 301 ( 3.5A)
4MD  A 401 ( 4.6A)
4MD  A 401 (-4.6A)
4MD  A 401 ( 4.4A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
None
0.40A59.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		3e0l GUANINE DEAMINASE
(Homo
sapiens)		5 / 12GLN A  87
HIS A  84
HIS A  82
PHE A 108
VAL A 169
None
ZN  A1452 (-3.1A)
ZN  A1452 (-3.3A)
None
None
1.05A20.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		3fe4 CARBONIC ANHYDRASE 6
(Homo
sapiens)		8 / 12GLN A 109
HIS A 111
HIS A 113
VAL A 140
VAL A 161
LEU A 219
THR A 220
TRP A 230
None
MG  A 901 (-3.4A)
MG  A 901 (-3.4A)
None
None
None
None
None
0.59A34.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		3fe4 CARBONIC ANHYDRASE 6
(Homo
sapiens)		6 / 12HIS A 111
HIS A 113
VAL A 140
VAL A 161
LEU A 219
THR A 220
 MG  A 901 (-3.4A)
MG  A 901 (-3.4A)
None
None
None
None
1.47A34.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		3jxf RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA
(Homo
sapiens)		6 / 12HIS A 129
HIS A 142
PHE A 166
VAL A 170
LEU A 235
THR A 236
None
0.96A30.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		3jxf RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA
(Homo
sapiens)		5 / 12HIS A 129
VAL A 170
LEU A 235
THR A 236
TRP A 246
None
0.94A30.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		6 / 12GLN A  67
HIS A  94
HIS A  96
LEU A 198
THR A 199
THR A 200
None
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
1.07A55.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		6 / 12GLN A  67
HIS A  96
VAL A 121
LEU A 198
THR A 199
THR A 200
None
ZN  A 263 ( 3.2A)
AZM  A 264 (-4.7A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
1.23A55.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		7 / 12GLN A  92
HIS A  94
HIS A  96
VAL A 121
PHE A 131
LEU A 198
THR A 199
AZM  A 264 (-4.1A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
AZM  A 264 (-4.7A)
AZM  A 264 (-4.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
1.38A55.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		10 / 12GLN A  92
HIS A  94
HIS A  96
VAL A 121
PHE A 131
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
AZM  A 264 (-4.1A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
AZM  A 264 (-4.7A)
AZM  A 264 (-4.4A)
AZM  A 264 ( 4.9A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
None
0.43A55.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		3uyq CARBONIC ANHYDRASE 3
(Homo
sapiens)		9 / 12GLN A  92
HIS A  94
HIS A  96
VAL A 121
PHE A 130
VAL A 142
THR A 198
THR A 199
TRP A 208
None
ZN  A 261 (-3.3A)
ZN  A 261 (-3.3A)
None
None
None
ZN  A 261 ( 4.4A)
None
None
0.36A58.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		4lg8 PRE-MRNA-PROCESSING
FACTOR 19
(Homo
sapiens)		5 / 12HIS A 217
VAL A 279
VAL A 267
LEU A 260
THR A 259
None
1.09A22.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		8 / 12GLN A  92
HIS A  94
HIS A  96
VAL A 121
PHE A 131
VAL A 135
LEU A 198
THR A 199
None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
None
None
None
ZN  A 301 ( 4.4A)
1.34A95.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		12 / 12HIS A  64
GLN A  92
HIS A  94
HIS A  96
VAL A 121
PHE A 131
VAL A 135
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
None
None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
None
None
None
None
ZN  A 301 ( 4.4A)
None
None
0.45A95.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		6 / 12HIS A  64
HIS A  96
VAL A 121
LEU A 198
THR A 199
THR A 200
None
ZN  A 301 (-3.2A)
None
None
ZN  A 301 ( 4.4A)
None
1.14A95.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		6 / 12HIS A  96
VAL A 143
VAL A 135
LEU A 198
THR A 199
THR A 200
 ZN  A 301 (-3.2A)
None
None
None
ZN  A 301 ( 4.4A)
None
1.13A95.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		6 / 12GLN A  67
HIS A  94
HIS A  96
LEU A 198
THR A 199
THR A 200
GOL  A 303 (-3.4A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
1.04A36.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		5 / 12GLN A  67
HIS A  96
VAL A 121
LEU A 198
THR A 200
GOL  A 303 (-3.4A)
ZN  A 301 ( 3.2A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
GOL  A 303 ( 3.5A)
1.11A36.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		9 / 12GLN A  92
HIS A  94
HIS A  96
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
GOL  A 303 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
520  A 302 ( 4.9A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
None
0.24A36.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		5 / 12HIS A  96
VAL A 143
LEU A 198
THR A 199
THR A 200
 ZN  A 301 ( 3.2A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
0.96A36.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		5grh ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT GAMMA,
MITOCHONDRIAL
(Homo
sapiens)		5 / 12VAL B  34
PHE B  47
VAL B  45
VAL B  37
LEU B 297
None
1.04A21.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		5jn9 CARBONIC ANHYDRASE 4
(Homo
sapiens)		10 / 12HIS A  64
GLN A  92
HIS A  94
HIS A  96
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
None
EZL  A 302 (-4.3A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
EZL  A 302 (-4.7A)
EZL  A 302 ( 4.7A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.4A)
EZL  A 302 (-3.9A)
None
0.51A35.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		5jn9 CARBONIC ANHYDRASE 4
(Homo
sapiens)		6 / 12HIS A  64
HIS A  96
LEU A 198
THR A 199
THR A 200
TRP A 209
None
ZN  A 301 ( 3.3A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.4A)
EZL  A 302 (-3.9A)
None
1.46A35.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens)		5 / 12HIS Q 301
HIS Q 267
VAL Q 312
LEU Q 305
THR Q 304
None
1.15A20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		6fe1 CARBONIC ANHYDRASE 9
(Homo
sapiens)		9 / 12GLN A  92
HIS A  94
HIS A  96
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
V14  A 302 (-3.8A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
V14  A 302 (-4.7A)
None
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
V14  A 302 (-3.5A)
None
0.47A14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		6fe1 CARBONIC ANHYDRASE 9
(Homo
sapiens)		7 / 12HIS A  94
HIS A  96
VAL A 121
VAL A 131
VAL A 143
LEU A 198
THR A 200
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
V14  A 302 (-4.7A)
V14  A 302 ( 4.6A)
None
V14  A 302 (-3.6A)
V14  A 302 (-3.5A)
1.11A14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		6fe1 CARBONIC ANHYDRASE 9
(Homo
sapiens)		5 / 12HIS A  96
VAL A 143
LEU A 198
THR A 199
THR A 200
 ZN  A 301 ( 3.2A)
None
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
V14  A 302 (-3.5A)
0.96A14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		1fy1 HEPARIN-BINDING
PROTEIN
(Homo
sapiens)		5 / 11SER A  75
SER A  74
LEU A  30
SER A  72
LEU A  95
None
1.06A18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		1xks NUCLEAR PORE COMPLEX
PROTEIN NUP133
(Homo
sapiens)		5 / 11SER A 292
SER A 291
GLN A 228
SER A 275
LEU A 274
None
1.08A23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		1zuo HYPOTHETICAL PROTEIN
LOC92912
(Homo
sapiens)		5 / 11SER A 228
LEU A 303
LEU A 330
LEU A 243
LEU A 292
None
0.99A18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		2qq8 TBC1 DOMAIN FAMILY
MEMBER 14
(Homo
sapiens)		5 / 11ALA A 641
LEU A 580
LEU A 634
LEU A 610
LYS A 609
None
None
None
UNX  A 202 ( 4.2A)
None
1.06A21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		2vxp TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3
(Homo
sapiens)		5 / 11ALA A 525
LEU A 509
LEU A 518
LEU A 569
LYS A 570
None
0.91A16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens)		6 / 11GLN A 238
LEU A 246
LEU A 248
SER A 265
LEU A 269
LEU A 276
T44  A1370 (-3.3A)
T44  A1370 (-4.6A)
None
None
T44  A1370 (-4.0A)
None
1.18A99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens)		8 / 11SER A  23
ALA A  27
GLN A 238
LEU A 246
LEU A 248
LEU A 269
ASN A 273
LEU A 276
T44  A1370 (-4.3A)
T44  A1370 ( 3.9A)
T44  A1370 (-3.3A)
T44  A1370 (-4.6A)
None
T44  A1370 (-4.0A)
T44  A1370 ( 3.3A)
None
0.95A99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens)		10 / 11SER A  23
SER A  24
ALA A  27
GLN A 238
LEU A 246
LEU A 248
LEU A 269
LYS A 270
ASN A 273
LEU A 276
T44  A1370 (-4.3A)
T44  A1370 ( 4.7A)
T44  A1370 ( 3.9A)
T44  A1370 (-3.3A)
T44  A1370 (-4.6A)
None
T44  A1370 (-4.0A)
T44  A1370 (-4.8A)
T44  A1370 ( 3.3A)
None
0.48A99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens)		10 / 11SER A  23
SER A  24
GLN A 238
LEU A 246
LEU A 248
SER A 266
LEU A 269
LYS A 270
ASN A 273
LEU A 276
T44  A1370 (-4.3A)
T44  A1370 ( 4.7A)
T44  A1370 (-3.3A)
T44  A1370 (-4.6A)
None
T44  A1370 ( 4.1A)
T44  A1370 (-4.0A)
T44  A1370 (-4.8A)
T44  A1370 ( 3.3A)
None
0.75A99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens)		6 / 11SER A  24
GLN A 238
LEU A 248
SER A 265
LEU A 269
LEU A 276
T44  A1370 ( 4.7A)
T44  A1370 (-3.3A)
None
None
T44  A1370 (-4.0A)
None
1.25A99.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		3b2d CD180 ANTIGEN
(Homo
sapiens)		5 / 11LEU A 474
LEU A 492
SER A 460
ASN A 479
LEU A 503
None
0.95A20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		3nmz APC VARIANT PROTEIN
(Homo
sapiens)		5 / 11SER A 624
LEU A 616
LEU A 585
LYS A 586
LEU A 592
None
1.09A21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		3rw7 NUCLEAR RNA EXPORT
FACTOR 1
(Homo
sapiens)		5 / 11SER A 305
LEU A 320
LEU A 280
LYS A 311
LEU A 315
None
1.02A21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		4bb9 GLUCOKINASE
REGULATORY PROTEIN
(Homo
sapiens)		5 / 11ALA A 287
LEU A 245
SER A 288
LEU A 292
LEU A  74
None
1.12A20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		5grq DEATH
DOMAIN-ASSOCIATED
PROTEIN 6
(Homo
sapiens)		5 / 11GLN A  77
LEU A  73
SER A 110
LEU A 113
LEU A 123
None
1.07A16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		5gtj DUAL SPECIFICITY
PROTEIN PHOSPHATASE
26
(Homo
sapiens)		5 / 11ALA A  94
GLN A 131
SER A 159
LEU A 162
LEU A 169
None
None
PO4  A 301 ( 4.1A)
None
None
0.82A22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3
(Homo
sapiens)		5 / 11ALA A 525
LEU A 509
LEU A 518
LEU A 569
LYS A 570
None
0.89A19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		5t5w INTERFERON LAMBDA
RECEPTOR 1
(Homo
sapiens)		5 / 11ALA B 141
LEU B 166
LEU B 119
SER B 177
LEU B 176
None
1.04A22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		5xbf HARMONIN
(Homo
sapiens)		5 / 11LEU B 468
LEU B 522
SER B 463
LYS B 488
LEU B 535
None
1.07A17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		5yq5 OSTEOMODULIN
(Homo
sapiens)		6 / 11LEU A 240
LEU A 219
SER A 201
LEU A 203
LYS A 204
LEU A 231
None
1.47A11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		5yq5 OSTEOMODULIN
(Homo
sapiens)		5 / 11SER A  74
SER A  75
LEU A 140
LEU A  96
LEU A 146
None
1.07A11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		1buy PROTEIN
(ERYTHROPOIETIN)
(Homo
sapiens)		3 / 3LEU A   5
ARG A 162
ILE A   6
None
0.64A12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		1jv1 GLCNAC1P
URIDYLTRANSFERASE
ISOFORM 1: AGX1
(Homo
sapiens)		3 / 3LEU A 146
ARG A 142
ILE A 160
None
0.57A8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		1ldk CULLIN HOMOLOG
(Homo
sapiens)		3 / 3LEU A 200
ARG A 199
ILE A 201
None
0.64A9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		3ff6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens)		3 / 3LEU A1743
ARG A1776
ILE A1742
None
0.62A3.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		3lh5 TIGHT JUNCTION
PROTEIN ZO-1
(Homo
sapiens)		3 / 3LEU A 535
ARG A 571
ILE A 574
None
0.52A19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1
(Homo
sapiens)		3 / 3LEU A 382
ARG A 325
ILE A 383
None
0.68A6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		5dcz TANKYRASE-2
(Homo
sapiens)		3 / 3LEU A1096
ARG A1094
ILE A1153
None
0.58A12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		5e6s INTEGRIN ALPHA-L
(Homo
sapiens)		3 / 3LEU A  25
ARG A  23
ILE A  32
None
0.53A4.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens)		3 / 3LEU A 767
ARG A 766
ILE A 768
None
0.67A1.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		5hck HEMATOPOIETIC CELL
KINASE
(Homo
sapiens)		3 / 3LEU A  97
ARG A 118
ILE A 128
None
0.68A20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		5iy7 TRANSCRIPTION
INITIATION FACTOR
IIB
(Homo
sapiens)		3 / 3LEU M 291
ARG M 290
ILE M 292
None
0.69A8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens)		3 / 3LEU A2758
ARG A2757
ILE A2759
None
0.63A1.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		5yjp HUMAN CHYMASE
(Homo
sapiens)		3 / 3LEU A  46
ARG A  49
ILE A  47
None
0.60A19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		1c25 CDC25A
(Homo
sapiens)		5 / 11PRO A 361
SER A 360
ILE A 359
VAL A 427
ILE A 395
None
1.31A18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		1om9 ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA1
(Homo
sapiens)		5 / 11PRO A 503
SER A 506
ILE A 507
VAL A 542
VAL A 544
None
1.33A25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		1whm CYLINDROMATOSIS
TUMOR SUPPRESSOR
CYLD
(Homo
sapiens)		5 / 11MET A  49
SER A  17
ILE A  24
VAL A  20
ILE A  53
None
0.95A18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		1whm CYLINDROMATOSIS
TUMOR SUPPRESSOR
CYLD
(Homo
sapiens)		5 / 11MET A  49
SER A  26
ILE A  24
VAL A  20
ILE A  53
None
1.28A18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		2ac5 MAP
KINASE-INTERACTING
SERINE/THREONINE
KINASE 2
(Homo
sapiens)		5 / 11SER A 166
ILE A 167
VAL A 222
VAL A 185
ILE A 224
None
1.25A16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		2ihd REGULATOR OF
G-PROTEIN SIGNALING
8
(Homo
sapiens)		5 / 11ILE A 123
VAL A 113
PHE A 112
VAL A 121
ILE A 108
None
1.24A19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		2l4c ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 27
(Homo
sapiens)		5 / 11SER A 108
ILE A 111
VAL A  35
PHE A  62
VAL A  60
None
1.32A23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		4da1 PROTEIN PHOSPHATASE
1K, MITOCHONDRIAL
(Homo
sapiens)		5 / 11PRO A 219
SER A 306
ILE A 309
VAL A 294
PHE A 292
None
1.36A17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		4eku PROTEIN-TYROSINE
KINASE 2-BETA
(Homo
sapiens)		5 / 11SER A  73
ILE A  70
PHE A  45
VAL A  43
ILE A  80
None
1.29A13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3
(Homo
sapiens)		5 / 11SER A 129
ILE A 126
VAL A 107
HIS A 144
ILE A 147
None
1.23A17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		4n2c PROTEIN-ARGININE
DEIMINASE TYPE-2
(Homo
sapiens)		5 / 11SER A 267
ILE A 268
VAL A 212
VAL A 252
ILE A 294
None
1.27A10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		4xbr PROTEIN
FAM212A,SERINE/THREO
NINE-PROTEIN KINASE
PAK 4
(Homo
sapiens)		5 / 11MET A 508
SER A 443
ILE A 446
VAL A 420
VAL A 454
None
1.31A15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		5oik TRANSCRIPTION
ELONGATION FACTOR
SPT4
TRANSCRIPTION
ELONGATION FACTOR
SPT5
(Homo
sapiens)		5 / 11SER Z 195
ILE Z 194
VAL Y   6
VAL Y  84
ILE Z 201
None
1.27A8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3
(Homo
sapiens)		5 / 11SER A 129
ILE A 126
VAL A 107
HIS A 144
ILE A 147
None
1.32A16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		1c25 CDC25A
(Homo
sapiens)		5 / 11ILE A 395
PRO A 361
SER A 360
ILE A 359
VAL A 427
None
1.35A18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		1om9 ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA1
(Homo
sapiens)		5 / 11PRO A 503
SER A 506
ILE A 507
VAL A 542
VAL A 544
None
1.33A25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		1whm CYLINDROMATOSIS
TUMOR SUPPRESSOR
CYLD
(Homo
sapiens)		5 / 11ILE A  53
MET A  49
SER A  17
ILE A  24
VAL A  20
None
0.95A18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		1whm CYLINDROMATOSIS
TUMOR SUPPRESSOR
CYLD
(Homo
sapiens)		5 / 11ILE A  53
MET A  49
SER A  26
ILE A  24
VAL A  20
None
1.32A18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		2ac5 MAP
KINASE-INTERACTING
SERINE/THREONINE
KINASE 2
(Homo
sapiens)		5 / 11ILE A 224
SER A 166
ILE A 167
VAL A 222
VAL A 185
None
1.20A16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		2ed7 NETRIN RECEPTOR DCC
(Homo
sapiens)		5 / 11ILE A 106
SER A  37
VAL A  91
PHE A  89
VAL A  53
None
1.21A22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		2l4c ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 27
(Homo
sapiens)		5 / 11SER A 108
ILE A 111
VAL A  35
PHE A  62
VAL A  60
None
1.35A23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		4da1 PROTEIN PHOSPHATASE
1K, MITOCHONDRIAL
(Homo
sapiens)		5 / 11PRO A 219
SER A 306
ILE A 309
VAL A 294
PHE A 292
None
1.34A17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		4eku PROTEIN-TYROSINE
KINASE 2-BETA
(Homo
sapiens)		5 / 11ILE A  80
SER A  73
ILE A  70
PHE A  45
VAL A  43
None
1.34A13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3
(Homo
sapiens)		5 / 11HIS A 144
ILE A 147
SER A 129
ILE A 126
VAL A 107
None
1.24A17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		4n2c PROTEIN-ARGININE
DEIMINASE TYPE-2
(Homo
sapiens)		5 / 11ILE A 294
SER A 267
ILE A 268
VAL A 212
VAL A 252
None
1.28A10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		4xbr PROTEIN
FAM212A,SERINE/THREO
NINE-PROTEIN KINASE
PAK 4
(Homo
sapiens)		5 / 11MET A 508
SER A 443
ILE A 446
VAL A 420
VAL A 454
None
1.33A15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		5oik TRANSCRIPTION
ELONGATION FACTOR
SPT4
TRANSCRIPTION
ELONGATION FACTOR
SPT5
(Homo
sapiens)		5 / 11ILE Z 201
SER Z 195
ILE Z 194
VAL Y   6
VAL Y  84
None
1.29A8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3
(Homo
sapiens)		5 / 11HIS A 144
ILE A 147
SER A 129
ILE A 126
VAL A 107
None
1.35A16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		1c25 CDC25A
(Homo
sapiens)		5 / 11ILE A 395
PRO A 361
SER A 360
ILE A 359
VAL A 427
None
1.33A18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		1om9 ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA1
(Homo
sapiens)		5 / 11PRO A 503
SER A 506
ILE A 507
VAL A 542
VAL A 544
None
1.34A25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		1whm CYLINDROMATOSIS
TUMOR SUPPRESSOR
CYLD
(Homo
sapiens)		5 / 11ILE A  53
MET A  49
SER A  17
ILE A  24
VAL A  20
None
0.95A18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		1whm CYLINDROMATOSIS
TUMOR SUPPRESSOR
CYLD
(Homo
sapiens)		5 / 11ILE A  53
MET A  49
SER A  26
ILE A  24
VAL A  20
None
1.32A18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		2ac5 MAP
KINASE-INTERACTING
SERINE/THREONINE
KINASE 2
(Homo
sapiens)		5 / 11ILE A 224
SER A 166
ILE A 167
VAL A 222
VAL A 185
None
1.18A16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		3gut TRANSCRIPTION FACTOR
P65
(Homo
sapiens)		5 / 11ILE A  23
ILE A  63
VAL A  21
PHE A 161
VAL A 163
None
1.15A16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		4da1 PROTEIN PHOSPHATASE
1K, MITOCHONDRIAL
(Homo
sapiens)		5 / 11PRO A 219
SER A 306
ILE A 309
VAL A 294
PHE A 292
None
1.35A17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		4eku PROTEIN-TYROSINE
KINASE 2-BETA
(Homo
sapiens)		5 / 11ILE A  80
SER A  73
ILE A  70
PHE A  45
VAL A  43
None
1.33A13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		4kwg ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens)		5 / 11ILE A 165
SER A 234
VAL A 241
PHE A 243
VAL A 265
None
0.98A15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3
(Homo
sapiens)		5 / 11HIS A 144
ILE A 147
SER A 129
ILE A 126
VAL A 107
None
1.24A17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		4n2c PROTEIN-ARGININE
DEIMINASE TYPE-2
(Homo
sapiens)		5 / 11ILE A 294
SER A 267
ILE A 268
VAL A 212
VAL A 252
None
1.27A10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		5oik TRANSCRIPTION
ELONGATION FACTOR
SPT4
TRANSCRIPTION
ELONGATION FACTOR
SPT5
(Homo
sapiens)		5 / 11ILE Z 201
SER Z 195
ILE Z 194
VAL Y   6
VAL Y  84
None
1.30A8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3
(Homo
sapiens)		5 / 11HIS A 144
ILE A 147
SER A 129
ILE A 126
VAL A 107
None
1.36A16.14