POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Seq. Identity (%)	View	Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	1k2p	TYROSINE-PROTEIN KINASE BTK (Homo sapiens)	7 / 12	ALA A 428 MET A 449 THR A 474 GLY A 480 CYH A 481 ASP A 539 PHE A 540	None	1.03A	31.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	1k2p	TYROSINE-PROTEIN KINASE BTK (Homo sapiens)	9 / 12	ALA A 428 THR A 474 GLY A 480 CYH A 481 LEU A 483 ARG A 487 LEU A 528 ASP A 539 PHE A 540	None	0.91A	31.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	1s9i	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2 (Homo sapiens)	5 / 12	ALA A  99 GLY A 153 LEU A 201 ASP A 212 PHE A 213	ATP  A 535 (-3.6A) ATP  A 535 ( 4.7A) ATP  A 535 (-4.8A) MG  A 536 (-3.3A) 5EA  A1001 (-3.6A)	0.51A	25.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	1snx	TYROSINE-PROTEIN KINASE ITK/TSK (Homo sapiens)	6 / 12	ALA A 389 GLY A 441 CYH A 442 ASP A 445 LEU A 489 PHE A 501	None	0.45A	31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	1snx	TYROSINE-PROTEIN KINASE ITK/TSK (Homo sapiens)	6 / 12	ALA A 389 MET A 410 ASP A 445 LEU A 489 ASP A 500 PHE A 501	None	0.86A	31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	1snx	TYROSINE-PROTEIN KINASE ITK/TSK (Homo sapiens)	6 / 12	ALA A 389 MET A 410 GLY A 441 ASP A 445 LEU A 489 PHE A 501	None	0.77A	31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	1snx	TYROSINE-PROTEIN KINASE ITK/TSK (Homo sapiens)	6 / 12	MET A 410 ASP A 445 ARG A 448 LEU A 489 ASP A 500 PHE A 501	None	1.12A	31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	1snx	TYROSINE-PROTEIN KINASE ITK/TSK (Homo sapiens)	6 / 12	MET A 410 GLY A 441 ASP A 445 ARG A 448 LEU A 489 PHE A 501	None	1.07A	31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	1t46	HOMO SAPIENS V-KIT HARDY-ZUCKERMAN 4 FELINE SARCOMA VIRAL ONCOGENE HOMOLOG (Homo sapiens)	6 / 12	ALA A 621 THR A 670 GLY A 676 LEU A 679 ARG A 683 LEU A 799	STI  A   3 (-3.5A) STI  A   3 (-3.2A) STI  A   3 ( 3.8A) None None STI  A   3 (-4.4A)	0.63A	31.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	2dq7	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE FYN (Homo sapiens)	7 / 12	ALA X  37 THR X  82 GLY X  88 LEU X  91 ASP X  92 LEU X 137 PHE X 149	STU  X 902 (-3.1A) STU  X 902 (-4.1A) STU  X 902 (-3.5A) None None STU  X 902 (-4.4A) None	0.89A	32.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	2dq7	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE FYN (Homo sapiens)	7 / 12	THR X  82 GLY X  88 LEU X  91 ASP X  92 LEU X 137 ASP X 148 PHE X 149	STU  X 902 (-4.1A) STU  X 902 (-3.5A) None None STU  X 902 (-4.4A) STU  X 902 (-3.6A) None	0.91A	32.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	2h8h	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC (Homo sapiens)	9 / 12	ALA A 293 MET A 314 THR A 338 GLY A 344 LEU A 347 ASP A 348 LEU A 393 ASP A 404 PHE A 405	H8H  A 534 (-3.2A) None H8H  A 534 (-3.1A) H8H  A 534 (-3.3A) None None H8H  A 534 (-4.5A) H8H  A 534 (-4.2A) None	0.89A	23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	2hck	HEMATOPOETIC CELL KINASE HCK (Homo sapiens)	7 / 12	ALA A 293 THR A 338 GLY A 344 LEU A 347 ASP A 348 LEU A 393 ASP A 404	QUE  A   1 (-3.5A) QUE  A   1 (-3.3A) QUE  A   1 (-3.0A) None QUE  A   1 ( 4.1A) QUE  A   1 (-4.4A) None	0.76A	27.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	2hck	HEMATOPOETIC CELL KINASE HCK (Homo sapiens)	6 / 12	MET A 314 THR A 338 GLY A 344 LEU A 347 ASP A 348 ASP A 404	None QUE  A   1 (-3.3A) QUE  A   1 (-3.0A) None QUE  A   1 ( 4.1A) None	0.97A	27.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	2hk5	TYROSINE-PROTEIN KINASE HCK (Homo sapiens)	6 / 12	ALA A 271 THR A 316 GLY A 322 LEU A 325 ASP A 326 LEU A 371	1BM  A 499 (-3.6A) 1BM  A 499 (-3.2A) 1BM  A 499 (-3.5A) None None 1BM  A 499 (-4.4A)	0.66A	32.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	2hk5	TYROSINE-PROTEIN KINASE HCK (Homo sapiens)	6 / 12	THR A 316 GLY A 322 LEU A 325 ASP A 326 LEU A 371 ASP A 382	1BM  A 499 (-3.2A) 1BM  A 499 (-3.5A) None None 1BM  A 499 (-4.4A) 1BM  A 499 (-4.4A)	0.76A	32.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	2hz0	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1 (Homo sapiens)	7 / 12	ALA A 269 THR A 315 GLY A 321 LEU A 324 ASP A 325 ARG A 328 LEU A 370	GIN  A 600 (-3.1A) GIN  A 600 (-3.4A) None None None None GIN  A 600 (-4.7A)	0.54A	34.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	2og8	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK (Homo sapiens)	5 / 12	ALA A 271 THR A 316 GLY A 322 ASP A 326 LEU A 371	1N8  A 501 ( 3.4A) 1N8  A 501 ( 3.3A) 1N8  A 501 ( 3.5A) None 1N8  A 501 ( 4.3A)	0.48A	33.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	2ogv	MACROPHAGE COLONY-STIMULATING FACTOR 1 RECEPTOR PRECURSOR (Homo sapiens)	6 / 12	MET A 637 GLY A 669 LEU A 672 ARG A 676 LEU A 785 ASP A 796	None	1.37A	32.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	2ogv	MACROPHAGE COLONY-STIMULATING FACTOR 1 RECEPTOR PRECURSOR (Homo sapiens)	6 / 12	THR A 663 GLY A 669 LEU A 672 ARG A 676 LEU A 785 ASP A 796	None	0.92A	32.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	2qlu	ACTIVIN RECEPTOR TYPE IIB (Homo sapiens)	6 / 12	ALA A 215 THR A 265 GLY A 271 ASP A 275 LEU A 328 ASP A 339	ADE  A 488 (-3.2A) ADE  A 488 (-4.3A) ADE  A 488 ( 4.1A) None ADE  A 488 (-4.4A) None	0.52A	25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	2qlu	ACTIVIN RECEPTOR TYPE IIB (Homo sapiens)	6 / 12	ALA A 215 THR A 265 GLY A 271 LEU A 328 ASP A 339 PHE A 340	ADE  A 488 (-3.2A) ADE  A 488 (-4.3A) ADE  A 488 ( 4.1A) ADE  A 488 (-4.4A) None None	0.87A	25.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	2r4b	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4 (Homo sapiens)	9 / 12	ALA A 749 MET A 772 THR A 796 GLY A 802 LEU A 805 LEU A 850 THR A 860 ASP A 861 PHE A 862	GW7  A   1 (-3.3A) GW7  A   1 ( 3.8A) GW7  A   1 (-4.0A) GW7  A   1 (-3.6A) None GW7  A   1 (-4.2A) GW7  A   1 (-3.5A) GW7  A   1 (-4.1A) GW7  A   1 (-3.8A)	0.47A	76.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	2y7j	PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, TESTIS/LIVER ISOFORM (Homo sapiens)	6 / 12	ALA A  51 GLY A 113 ASP A 117 LEU A 160 ASP A 171 PHE A 172	B49  A1294 (-3.2A) B49  A1294 (-3.6A) None B49  A1294 (-4.4A) B49  A1294 (-4.2A) None	0.96A	25.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	3d7u	TYROSINE-PROTEIN KINASE CSK (Homo sapiens)	6 / 12	ALA A 220 THR A 266 GLY A 272 ASP A 276 ARG A 279 LEU A 321	None	0.59A	32.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	3d7u	TYROSINE-PROTEIN KINASE CSK (Homo sapiens)	6 / 12	THR A 266 GLY A 272 ASP A 276 ARG A 279 LEU A 321 ASP A 332	None	0.57A	32.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	3dtc	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 9 (Homo sapiens)	5 / 12	ALA A 169 GLY A 226 LEU A 275 THR A 293 PHE A 295	VIN  A6331 (-3.4A) VIN  A6331 (-3.4A) VIN  A6331 (-4.5A) VIN  A6331 (-3.6A) None	0.48A	30.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	3i6u	SERINE/THREONINE-PRO TEIN KINASE CHK2 (Homo sapiens)	7 / 12	ALA A 247 GLY A 307 ASP A 311 LEU A 354 THR A 367 ASP A 368 PHE A 369	None	0.78A	22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	3iec	SERINE/THREONINE-PRO TEIN KINASE MARK2 (Homo sapiens)	6 / 12	ALA A  80 MET A 104 GLY A 135 ASP A 139 LEU A 182 PHE A 194	None	1.14A	25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	3iec	SERINE/THREONINE-PRO TEIN KINASE MARK2 (Homo sapiens)	6 / 12	MET A 104 GLY A 135 ASP A 139 LEU A 182 ASP A 193 PHE A 194	None	1.23A	25.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	3kex	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3 (Homo sapiens)	8 / 12	THR A 768 GLY A 774 LEU A 777 ASP A 778 ARG A 781 LEU A 822 ASP A 833 PHE A 834	ANP  A   1 ( 4.8A) ANP  A   1 ( 4.9A) None None None ANP  A   1 (-4.7A) MG  A1001 ( 3.1A) None	0.56A	51.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	3kul	EPHRIN TYPE-A RECEPTOR 8 (Homo sapiens)	6 / 12	ALA A 665 THR A 713 GLY A 719 ARG A 726 LEU A 767 ASP A 778	None None GOL  A 403 (-3.4A) None None None	0.81A	34.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	3lzb	EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens)	12 / 12	ALA A 719 MET A 742 THR A 766 GLY A 772 CYH A 773 LEU A 775 ASP A 776 ARG A 779 LEU A 820 THR A 830 ASP A 831 PHE A 832	ITI  A   1 (-2.9A) ITI  A   1 (-3.4A) ITI  A   1 (-3.8A) ITI  A   1 (-3.5A) ITI  A   1 (-4.8A) None None None ITI  A   1 (-4.6A) ITI  A   1 (-3.8A) ITI  A   1 ( 4.6A) ITI  A   1 (-3.6A)	0.75A	87.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	3nuu	PKB-LIKE (Homo sapiens)	6 / 12	ALA A 109 GLY A 165 LEU A 168 ARG A 172 LEU A 212 THR A 222	JOZ  A 361 (-3.4A) None None None None JOZ  A 361 (-3.7A)	0.70A	28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	3nuu	PKB-LIKE (Homo sapiens)	6 / 12	ALA A 109 GLY A 165 LEU A 168 LEU A 212 THR A 222 PHE A 224	JOZ  A 361 (-3.4A) None None None JOZ  A 361 (-3.7A) None	0.96A	28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	3nuu	PKB-LIKE (Homo sapiens)	6 / 12	GLY A 165 LEU A 168 ARG A 172 LEU A 212 THR A 222 ASP A 223	None None None None JOZ  A 361 (-3.7A) SO4  A   5 ( 4.5A)	0.80A	28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	3nuu	PKB-LIKE (Homo sapiens)	6 / 12	GLY A 165 LEU A 168 LEU A 212 THR A 222 ASP A 223 PHE A 224	None None None JOZ  A 361 (-3.7A) SO4  A   5 ( 4.5A) None	1.04A	28.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	3pp0	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 (Homo sapiens)	10 / 12	ALA A 751 MET A 774 THR A 798 GLY A 804 CYH A 805 LEU A 807 ASP A 808 ARG A 811 LEU A 852 THR A 862	03Q  A   1 (-3.1A) 03Q  A   1 (-4.5A) 03Q  A   1 (-4.1A) 03Q  A   1 ( 3.9A) None None None None 03Q  A   1 (-4.4A) 03Q  A   1 (-3.3A)	1.13A	73.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	3pp0	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 (Homo sapiens)	10 / 12	ALA A 751 THR A 798 GLY A 804 CYH A 805 LEU A 807 ASP A 808 ARG A 811 LEU A 852 THR A 862 ASP A 863	03Q  A   1 (-3.1A) 03Q  A   1 (-4.1A) 03Q  A   1 ( 3.9A) None None None None 03Q  A   1 (-4.4A) 03Q  A   1 (-3.3A) 03Q  A   1 (-4.0A)	0.46A	73.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	3pp0	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 (Homo sapiens)	7 / 12	ALA A 751 THR A 798 GLY A 804 LEU A 852 THR A 862 ASP A 863 PHE A 864	03Q  A   1 (-3.1A) 03Q  A   1 (-4.1A) 03Q  A   1 ( 3.9A) 03Q  A   1 (-4.4A) 03Q  A   1 (-3.3A) 03Q  A   1 (-4.0A) 03Q  A   1 (-4.2A)	0.76A	73.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	3q4t	ACTIVIN RECEPTOR TYPE-2A (Homo sapiens)	6 / 12	ALA A 217 THR A 267 GLY A 273 LEU A 329 ASP A 340 PHE A 341	TAK  A   2 (-3.5A) TAK  A   2 (-3.5A) TAK  A   2 (-3.6A) TAK  A   2 (-4.6A) None None	0.88A	28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	3sxs	CYTOPLASMIC TYROSINE-PROTEIN KINASE BMX (Homo sapiens)	7 / 12	ALA A 443 THR A 489 GLY A 495 CYH A 496 LEU A 498 ARG A 502 LEU A 543	PP2  A   1 (-3.2A) PP2  A   1 (-3.3A) PP2  A   1 ( 4.2A) None None None PP2  A   1 (-4.6A)	0.81A	29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	3wig	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 (Homo sapiens)	5 / 12	ALA A  96 GLY A 150 LEU A 198 ASP A 209 PHE A 210	ANP  A 401 (-3.2A) ANP  A 401 ( 4.3A) ANP  A 401 (-4.8A) MG  A 402 (-3.2A) CHU  A 403 (-3.8A)	0.43A	25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	3zbf	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ROS (Homo sapiens)	6 / 12	GLY A2032 LEU A2035 ARG A2039 LEU A2086 ASP A2102 PHE A2103	VGH  A3000 (-3.5A) None None VGH  A3000 (-4.3A) None None	0.90A	38.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	3zfx	EPHRIN TYPE-B RECEPTOR 1 (Homo sapiens)	6 / 12	ALA A 649 THR A 697 GLY A 703 LEU A 751 ASP A 762 PHE A 763	None	0.91A	36.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	4c02	ACTIVIN RECEPTOR TYPE-1 (Homo sapiens)	6 / 12	ALA A 233 THR A 283 GLY A 289 ASP A 293 LEU A 343 ASP A 354	TAK  A1507 (-3.3A) TAK  A1507 (-3.6A) TAK  A1507 (-3.5A) None TAK  A1507 (-4.7A) TAK  A1507 (-3.5A)	0.73A	23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	4e93	TYROSINE-PROTEIN KINASE FES/FPS (Homo sapiens)	7 / 12	ALA A 588 GLY A 642 LEU A 645 ARG A 649 LEU A 690 ASP A 701 PHE A 702	GUI  A 901 (-3.4A) GUI  A 901 (-3.5A) None None GUI  A 901 (-4.3A) GUI  A 901 ( 4.1A) None	0.83A	25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	4fl3	TYROSINE-PROTEIN KINASE SYK (Homo sapiens)	6 / 12	ALA A 400 MET A 424 GLY A 454 LEU A 501 ASP A 512 PHE A 513	ANP  A 701 (-3.3A) None ANP  A 701 ( 4.2A) ANP  A 701 (-4.5A) MG  A 702 ( 3.1A) None	0.96A	22.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	4hvi	TYROSINE-PROTEIN KINASE JAK3 (Homo sapiens)	6 / 12	ALA A 853 GLY A 908 CYH A 909 ASP A 912 LEU A 956 PHE A 968	19S  A1201 (-3.3A) 19S  A1201 ( 3.8A) None None 19S  A1201 (-4.5A) None	0.85A	33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	4hvi	TYROSINE-PROTEIN KINASE JAK3 (Homo sapiens)	6 / 12	GLY A 908 CYH A 909 ASP A 912 LEU A 956 ASP A 967 PHE A 968	19S  A1201 ( 3.8A) None None 19S  A1201 (-4.5A) 19S  A1201 ( 4.1A) None	0.94A	33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	4hzs	ACTIVATED CDC42 KINASE 1 (Homo sapiens)	9 / 12	ALA A 156 MET A 181 THR A 205 GLY A 211 LEU A 214 ASP A 215 ARG A 218 ASP A 270 PHE A 271	None	0.95A	36.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	4hzs	ACTIVATED CDC42 KINASE 1 (Homo sapiens)	9 / 12	ALA A 156 THR A 205 GLY A 211 LEU A 214 ASP A 215 ARG A 218 LEU A 259 ASP A 270 PHE A 271	None	0.88A	36.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	4id7	ACTIVATED CDC42 KINASE 1 (Homo sapiens)	8 / 12	ALA A 156 MET A 181 THR A 205 GLY A 211 LEU A 214 ASP A 215 ARG A 218 LEU A 259	1G0  A 401 (-3.6A) 1G0  A 401 (-4.0A) 1G0  A 401 (-3.2A) 1G0  A 401 ( 4.5A) None None None 1G0  A 401 (-4.6A)	1.32A	34.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	4id7	ACTIVATED CDC42 KINASE 1 (Homo sapiens)	8 / 12	MET A 181 THR A 205 GLY A 211 LEU A 214 ASP A 215 ARG A 218 LEU A 259 ASP A 270	1G0  A 401 (-4.0A) 1G0  A 401 (-3.2A) 1G0  A 401 ( 4.5A) None None None 1G0  A 401 (-4.6A) None	1.27A	34.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	4k11	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC (Homo sapiens)	7 / 12	ALA A 293 GLY A 344 LEU A 347 ASP A 348 LEU A 393 ASP A 404 PHE A 405	0J9  A 601 (-3.3A) 0J9  A 601 ( 4.1A) None None 0J9  A 601 (-4.5A) 0J9  A 601 (-3.1A) None	0.43A	26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	4k11	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC (Homo sapiens)	7 / 12	MET A 314 GLY A 344 LEU A 347 ASP A 348 LEU A 393 ASP A 404 PHE A 405	None 0J9  A 601 ( 4.1A) None None 0J9  A 601 (-4.5A) 0J9  A 601 (-3.1A) None	0.76A	26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	4rew	5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1 (Homo sapiens)	6 / 12	ALA A  45 GLY A 101 ASP A 105 LEU A 148 ASP A 159 PHE A 160	STU  A 601 (-3.2A) STU  A 601 ( 3.8A) None STU  A 601 (-4.2A) STU  A 601 (-3.7A) None	1.19A	21.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	4uy9	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 9 (Homo sapiens)	6 / 12	ALA A 169 GLY A 226 LEU A 275 THR A 293 ASP A 294 PHE A 295	None	0.57A	30.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	4xey	TYROSINE-PROTEIN KINASE ABL1 (Homo sapiens)	6 / 12	ALA B 288 THR B 334 GLY B 340 LEU B 343 ASP B 344 LEU B 389	1N1  B 601 (-3.5A) 1N1  B 601 (-3.3A) 1N1  B 601 (-3.5A) None None 1N1  B 601 (-4.3A)	0.87A	29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	4xey	TYROSINE-PROTEIN KINASE ABL1 (Homo sapiens)	6 / 12	THR B 334 GLY B 340 LEU B 343 ASP B 344 ARG B 347 LEU B 389	1N1  B 601 (-3.3A) 1N1  B 601 (-3.5A) None None None 1N1  B 601 (-4.3A)	0.68A	29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	4yff	SERINE/THREONINE-PRO TEIN KINASE TNNI3K (Homo sapiens)	6 / 12	ALA A 488 THR A 539 GLY A 545 LEU A 595 ASP A 606 PHE A 607	4CV  A 801 (-3.5A) 4CV  A 801 (-2.8A) 4CV  A 801 ( 4.0A) 4CV  A 801 (-4.4A) 4CV  A 801 (-3.5A) None	1.00A	26.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	5ci7	SERINE/THREONINE-PRO TEIN KINASE ULK1 (Homo sapiens)	6 / 12	ALA A  44 GLY A  98 ASP A 102 LEU A 145 ASP A 165 PHE A 166	51W  A 401 (-3.4A) 51W  A 401 (-3.7A) None 51W  A 401 (-4.5A) GOL  A 404 (-3.2A) None	0.94A	25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	5d7a	TRAF2 AND NCK-INTERACTING PROTEIN KINASE (Homo sapiens)	5 / 12	ALA A  52 GLY A 111 LEU A 160 ASP A 171 PHE A 172	ALA  A  52 (-0.0A) GLY  A 111 (-0.0A) LEU  A 160 (-0.6A) ASP  A 171 ( 0.5A) PHE  A 172 ( 1.3A)	0.51A	25.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	5f1z	NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2 (Homo sapiens)	6 / 12	ALA A 928 GLY A 984 ASP A 988 LEU A1030 ASP A1041 PHE A1042	5U3  A1200 (-3.5A) 5U3  A1200 (-3.2A) None 5U3  A1200 (-4.4A) 5U3  A1200 ( 4.9A) None	0.99A	30.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	5hes	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLT (Homo sapiens)	6 / 12	ALA A  43 THR A  82 GLY A  88 ASP A  92 ASP A 151 PHE A 152	032  A 401 (-3.2A) 032  A 401 (-3.7A) 032  A 401 ( 4.0A) 032  A 401 (-4.3A) 032  A 401 (-4.6A) 032  A 401 (-4.1A)	0.75A	25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	5iso	5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-2 (Homo sapiens)	6 / 12	ALA A  43 GLY A  99 ASP A 103 LEU A 146 ASP A 157 PHE A 158	STU  A 601 (-3.3A) STU  A 601 ( 4.0A) None STU  A 601 (-4.5A) STU  A 601 (-3.5A) None	1.13A	20.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	5j9z	EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens)	10 / 12	ALA A 743 GLY A 796 CYH A 797 LEU A 799 ASP A 800 ARG A 803 LEU A 844 THR A 854 ASP A 855 PHE A 856	6HJ  A1101 (-3.1A) 6HJ  A1101 ( 4.5A) 6HJ  A1101 (-1.6A) None 6HJ  A1101 ( 4.1A) None 6HJ  A1101 ( 4.8A) 6HJ  A1101 (-3.9A) 6HJ  A1101 (-4.3A) None	0.81A	99.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	5kbr	SERINE/THREONINE-PRO TEIN KINASE PAK 1 (Homo sapiens)	6 / 12	ALA A 297 GLY A 350 ASP A 354 LEU A 396 THR A 406 PHE A 408	IPW  A 601 (-3.5A) IPW  A 601 ( 3.8A) None IPW  A 601 (-4.5A) IPW  A 601 (-3.7A) None	0.79A	25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	5loh	SERINE/THREONINE-PRO TEIN KINASE GREATWALL,SERINE/THR EONINE-PROTEIN KINASE GREATWALL (Homo sapiens)	5 / 12	ALA A  60 GLY A 116 LEU A 163 THR A 173 PHE A 175	STU  A 901 (-3.3A) STU  A 901 (-3.5A) STU  A 901 (-4.5A) STU  A 901 (-3.5A) None	0.44A	25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	6ao5	SERINE/THREONINE-PRO TEIN KINASE 3 (Homo sapiens)	6 / 12	ALA A  54 GLY A 105 ARG A 112 LEU A 153 ASP A 164 PHE A 165	ANP  A 501 ( 3.7A) ANP  A 501 ( 4.0A) None ANP  A 501 (-4.6A) MG  A 502 ( 3.1A) None	0.93A	26.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	6ao5	SERINE/THREONINE-PRO TEIN KINASE 3 (Homo sapiens)	6 / 12	ALA A  54 MET A  74 GLY A 105 LEU A 153 ASP A 164 PHE A 165	ANP  A 501 ( 3.7A) None ANP  A 501 ( 4.0A) ANP  A 501 (-4.6A) MG  A 502 ( 3.1A) None	0.72A	26.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	6bfn	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1 (Homo sapiens)	6 / 12	ALA A 237 GLY A 294 ASP A 298 LEU A 347 ASP A 358 PHE A 359	DL1  A 601 (-3.4A) DL1  A 601 (-3.5A) DL1  A 601 ( 4.9A) DL1  A 601 (-3.9A) DL1  A 601 (-3.1A) None	1.01A	13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	6cz4	PROTEIN-TYROSINE KINASE 6 (Homo sapiens)	6 / 12	ALA A 217 MET A 239 THR A 264 GLY A 270 LEU A 273 LEU A 319	FKY  A9001 (-3.3A) FKY  A9001 (-4.2A) FKY  A9001 (-3.0A) FKY  A9001 (-3.3A) None FKY  A9001 ( 4.9A)	0.98A	16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	6cz4	PROTEIN-TYROSINE KINASE 6 (Homo sapiens)	6 / 12	MET A 239 GLY A 270 LEU A 273 ARG A 277 LEU A 319 ASP A 330	FKY  A9001 (-4.2A) FKY  A9001 (-3.3A) None None FKY  A9001 ( 4.9A) None	0.92A	16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	6cz4	PROTEIN-TYROSINE KINASE 6 (Homo sapiens)	6 / 12	MET A 239 THR A 264 GLY A 270 LEU A 273 ARG A 277 LEU A 319	FKY  A9001 (-4.2A) FKY  A9001 (-3.0A) FKY  A9001 (-3.3A) None None FKY  A9001 ( 4.9A)	0.59A	16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	1cm8	PHOSPHORYLATED MAP KINASE P38-GAMMA (Homo sapiens)	5 / 9	VAL A  41 LYS A  56 LEU A  89 LEU A 107 MET A 112	ANP  A 400 (-4.1A) ANP  A 400 (-2.9A) None None None	0.68A	27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	1ua2	CELL DIVISION PROTEIN KINASE 7 (Homo sapiens)	5 / 9	LEU A  18 VAL A  26 LEU A  77 LEU A  89 MET A  94	ATP  A 381 (-4.4A) ATP  A 381 (-4.0A) None None None	0.50A	22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	1ua2	CELL DIVISION PROTEIN KINASE 7 (Homo sapiens)	5 / 9	LEU A  18 VAL A  26 LYS A  41 LEU A  77 LEU A  89	ATP  A 381 (-4.4A) ATP  A 381 (-4.0A) ATP  A 381 (-2.9A) None None	0.76A	22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	1zws	DAP-KINASE RELATED PROTEIN 1 (Homo sapiens)	5 / 9	LEU A  19 VAL A  27 LEU A  79 LEU A  91 LEU A  95	None	0.69A	25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	2a2a	DEATH-ASSOCIATED PROTEIN KINASE 2 (Homo sapiens)	6 / 9	LEU A  19 VAL A  27 LYS A  42 LEU A  79 LEU A  91 LEU A  95	None	0.73A	24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	2b1p	MITOGEN-ACTIVATED PROTEIN KINASE 10 (Homo sapiens)	6 / 9	VAL A  78 LYS A  93 LEU A 126 LEU A 144 LEU A 148 MET A 149	AIZ  A 501 ( 4.7A) AIZ  A 501 (-3.8A) None AIZ  A 501 (-4.2A) AIZ  A 501 ( 4.7A) None	0.49A	23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	2h8h	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC (Homo sapiens)	6 / 9	LEU A 273 VAL A 281 LYS A 295 LEU A 325 MET A 341 LEU A 407	H8H  A 534 (-3.8A) H8H  A 534 (-4.4A) H8H  A 534 (-3.7A) None None None	0.58A	23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	2hck	HEMATOPOETIC CELL KINASE HCK (Homo sapiens)	5 / 9	LEU A 273 VAL A 281 LYS A 295 LEU A 325 MET A 341	QUE  A   1 (-3.9A) QUE  A   1 ( 4.8A) None None None	0.62A	27.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	2hz0	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1 (Homo sapiens)	5 / 9	LEU A 248 VAL A 256 LYS A 271 LEU A 301 MET A 318	GIN  A 600 ( 4.6A) GIN  A 600 ( 4.7A) GIN  A 600 (-3.6A) None None	0.76A	34.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	2jam	CALCIUM/CALMODULIN-D EPENDENT PROTEIN KINASE TYPE 1G (Homo sapiens)	5 / 9	LEU A  29 VAL A  37 LEU A  84 LEU A  96 LEU A 100	J60  A1305 (-3.9A) J60  A1305 (-4.8A) None None J60  A1305 (-4.4A)	0.42A	25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	2jam	CALCIUM/CALMODULIN-D EPENDENT PROTEIN KINASE TYPE 1G (Homo sapiens)	5 / 9	VAL A  37 LYS A  52 LEU A  84 LEU A  96 LEU A 100	J60  A1305 (-4.8A) EDO  A1304 ( 2.9A) None None J60  A1305 (-4.4A)	0.59A	25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	2jc6	CALCIUM/CALMODULIN-D EPENDENT PROTEIN KINASE TYPE 1D (Homo sapiens)	6 / 9	LEU A  29 VAL A  37 LYS A  52 LEU A  84 LEU A  96 LEU A 100	QPP  A1314 (-3.7A) QPP  A1314 ( 4.6A) None None None QPP  A1314 (-4.5A)	0.61A	26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	2ozo	TYROSINE-PROTEIN KINASE ZAP-70 (Homo sapiens)	6 / 9	LEU A 344 VAL A 352 LYS A 369 LEU A 401 LEU A 412 LEU A 482	ANP  A 615 (-4.4A) ANP  A 615 (-4.5A) ANP  A 615 (-3.1A) None None None	0.91A	21.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	2r4b	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4 (Homo sapiens)	8 / 9	LEU A 724 VAL A 732 LYS A 751 LEU A 783 LEU A 794 LEU A 798 MET A 799 LEU A 864	GW7  A   1 ( 4.2A) GW7  A   1 ( 4.8A) GW7  A   1 (-3.9A) GW7  A   1 (-3.9A) GW7  A   1 (-4.1A) GW7  A   1 (-4.5A) None GW7  A   1 ( 4.7A)	0.33A	76.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	2w4k	DEATH-ASSOCIATED PROTEIN KINASE 1 (Homo sapiens)	6 / 9	LEU A  19 VAL A  27 LYS A  42 LEU A  79 LEU A  91 LEU A  95	ADP  A1303 ( 3.9A) ADP  A1303 (-4.0A) ADP  A1303 (-2.7A) None None None	0.70A	24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	2w4o	CALCIUM/CALMODULIN-D EPENDENT PROTEIN KINASE TYPE IV (Homo sapiens)	5 / 9	LEU A  52 VAL A  60 LEU A 104 LEU A 116 LEU A 120	DKI  A1338 (-3.8A) DKI  A1338 (-4.2A) None None DKI  A1338 (-4.2A)	0.44A	27.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	2w4o	CALCIUM/CALMODULIN-D EPENDENT PROTEIN KINASE TYPE IV (Homo sapiens)	5 / 9	VAL A  60 LYS A  75 LEU A 104 LEU A 116 LEU A 120	DKI  A1338 (-4.2A) None None None DKI  A1338 (-4.2A)	0.63A	27.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	2wbi	ACYL-COA DEHYDROGENASE FAMILY MEMBER 11 (Homo sapiens)	6 / 9	LEU A 127 VAL A 126 CYH A 153 LEU A 201 LEU A 219 LEU A 276	None	1.23A	21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	2x4f	MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4 (Homo sapiens)	5 / 9	LEU A 112 VAL A 120 LYS A 135 LEU A 166 LEU A 178	16X  A1374 (-4.1A) 16X  A1374 (-4.8A) 16X  A1374 ( 4.3A) None None	0.47A	25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	2xk9	CHECKPOINT KINASE 2 (Homo sapiens)	5 / 9	LEU A 226 VAL A 234 LYS A 249 LEU A 303 MET A 304	XK9  A1511 (-3.8A) XK9  A1511 (-4.8A) XK9  A1511 (-4.2A) XK9  A1511 (-4.1A) None	0.73A	25.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	2y7j	PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, TESTIS/LIVER ISOFORM (Homo sapiens)	5 / 9	VAL A  38 LEU A  93 LEU A 105 LEU A 109 MET A 110	None None None B49  A1294 ( 4.7A) None	0.45A	25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	2y7j	PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, TESTIS/LIVER ISOFORM (Homo sapiens)	5 / 9	VAL A  38 LYS A  53 LEU A  93 LEU A 105 MET A 110	None	0.65A	25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	2z7r	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1 (Homo sapiens)	5 / 9	LEU A  68 VAL A  76 LYS A  94 LEU A 127 LEU A 139	STU  A   1 (-3.8A) None STU  A   1 (-2.8A) None None	0.54A	26.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	2z8c	INSULIN RECEPTOR (Homo sapiens)	5 / 9	LEU A1002 VAL A1010 LEU A1062 LEU A1078 MET A1079	S91  A   1 ( 4.1A) S91  A   1 ( 4.9A) None S91  A   1 (-4.7A) None	0.57A	31.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	2z8c	INSULIN RECEPTOR (Homo sapiens)	5 / 9	LEU A1002 VAL A1010 LYS A1030 LEU A1062 LEU A1078	S91  A   1 ( 4.1A) S91  A   1 ( 4.9A) S91  A   1 ( 4.2A) None S91  A   1 (-4.7A)	0.61A	31.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	3bqr	DEATH-ASSOCIATED PROTEIN KINASE 3 (Homo sapiens)	5 / 9	LEU A  19 VAL A  27 LEU A  79 LEU A  91 LEU A  95	4RB  A 401 ( 3.9A) 4RB  A 401 ( 4.4A) PGO  A 501 ( 4.6A) None 4RB  A 401 (-4.4A)	0.47A	24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	3coi	MITOGEN-ACTIVATED PROTEIN KINASE 13 (Homo sapiens)	5 / 9	VAL A  39 LYS A  54 LEU A  87 LEU A 105 MET A 110	None	0.75A	26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	3e7o	MITOGEN-ACTIVATED PROTEIN KINASE 9 (Homo sapiens)	6 / 9	VAL A  40 LYS A  55 LEU A  88 LEU A 106 LEU A 110 MET A 111	35F  A   1 ( 4.8A) 35F  A   1 ( 4.6A) None None 35F  A   1 (-4.5A) None	0.66A	25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	3f2a	PROTO-ONCOGENE SERINE/THREONINE-PRO TEIN KINASE PIM-1 (Homo sapiens)	5 / 9	LEU A  44 VAL A  52 LYS A  67 LEU A 106 LEU A 118	985  A   1 (-4.1A) 985  A   1 (-4.5A) 985  A   1 ( 2.8A) None None	0.65A	23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	3gp0	MITOGEN-ACTIVATED PROTEIN KINASE 11 (Homo sapiens)	5 / 9	VAL A  38 LEU A  86 LEU A 104 LEU A 108 MET A 109	NIL  A   1 ( 4.7A) None NIL  A   1 ( 4.3A) NIL  A   1 ( 4.4A) None	0.63A	25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	3gp0	MITOGEN-ACTIVATED PROTEIN KINASE 11 (Homo sapiens)	5 / 9	VAL A  38 LYS A  53 LEU A  86 LEU A 104 LEU A 108	NIL  A   1 ( 4.7A) None None NIL  A   1 ( 4.3A) NIL  A   1 ( 4.4A)	0.67A	25.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	3kex	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3 (Homo sapiens)	5 / 9	LEU A 696 VAL A 704 LYS A 723 LEU A 755 LEU A 766	ANP  A   1 (-4.4A) ANP  A   1 (-3.9A) ANP  A   1 (-3.4A) None None	0.40A	51.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	3lm5	SERINE/THREONINE-PRO TEIN KINASE 17B (Homo sapiens)	5 / 9	LEU A  39 VAL A  47 LYS A  62 LEU A  96 LEU A 108	QUE  A   1 ( 3.8A) QUE  A   1 ( 4.6A) QUE  A   1 (-4.1A) None None	0.78A	27.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	3lzb	EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens)	6 / 9	LEU A 694 VAL A 702 CYH A 751 LEU A 753 LEU A 768 MET A 769	ITI  A   1 (-3.9A) ITI  A   1 (-4.8A) ITI  A   1 (-3.7A) ITI  A   1 (-3.8A) ITI  A   1 (-4.8A) ITI  A   1 (-4.8A)	1.14A	87.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	3lzb	EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens)	6 / 9	LEU A 694 VAL A 702 LEU A 753 LEU A 764 LEU A 768 MET A 769	ITI  A   1 (-3.9A) ITI  A   1 (-4.8A) ITI  A   1 (-3.8A) ITI  A   1 ( 4.2A) ITI  A   1 (-4.8A) ITI  A   1 (-4.8A)	0.93A	87.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	3lzb	EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens)	6 / 9	LEU A 694 VAL A 702 LYS A 721 LEU A 753 LEU A 764 LEU A 768	ITI  A   1 (-3.9A) ITI  A   1 (-4.8A) ITI  A   1 (-2.6A) ITI  A   1 (-3.8A) ITI  A   1 ( 4.2A) ITI  A   1 (-4.8A)	0.81A	87.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	3lzb	EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens)	6 / 9	VAL A 702 CYH A 751 LEU A 753 LEU A 768 MET A 769 LEU A 834	ITI  A   1 (-4.8A) ITI  A   1 (-3.7A) ITI  A   1 (-3.8A) ITI  A   1 (-4.8A) ITI  A   1 (-4.8A) None	1.19A	87.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	3lzb	EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens)	6 / 9	VAL A 702 LEU A 753 LEU A 764 LEU A 768 MET A 769 LEU A 834	ITI  A   1 (-4.8A) ITI  A   1 (-3.8A) ITI  A   1 ( 4.2A) ITI  A   1 (-4.8A) ITI  A   1 (-4.8A) None	1.01A	87.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	3lzb	EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens)	6 / 9	VAL A 702 LYS A 721 LEU A 753 LEU A 764 LEU A 768 LEU A 834	ITI  A   1 (-4.8A) ITI  A   1 (-2.6A) ITI  A   1 (-3.8A) ITI  A   1 ( 4.2A) ITI  A   1 (-4.8A) None	0.95A	87.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	3nyo	G PROTEIN-COUPLED RECEPTOR KINASE 6 (Homo sapiens)	6 / 9	LEU A 192 VAL A 200 LEU A 238 LEU A 261 LEU A 265 MET A 266	AMP  A 577 ( 4.3A) AMP  A 577 (-4.3A) None None AMP  A 577 ( 4.9A) None	1.17A	19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	3nyo	G PROTEIN-COUPLED RECEPTOR KINASE 6 (Homo sapiens)	6 / 9	LEU A 192 VAL A 200 LEU A 249 LEU A 261 LEU A 265 MET A 266	AMP  A 577 ( 4.3A) AMP  A 577 (-4.3A) None None AMP  A 577 ( 4.9A) None	0.70A	19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	3nyo	G PROTEIN-COUPLED RECEPTOR KINASE 6 (Homo sapiens)	6 / 9	VAL A 200 LYS A 215 LEU A 249 LEU A 261 LEU A 265 MET A 266	AMP  A 577 (-4.3A) AMP  A 577 (-2.8A) None None AMP  A 577 ( 4.9A) None	0.77A	19.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	3pp0	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 (Homo sapiens)	6 / 9	LEU A 726 VAL A 734 LEU A 785 LEU A 796 LEU A 800 MET A 801	03Q  A   1 (-3.8A) 03Q  A   1 (-4.5A) 03Q  A   1 (-3.1A) 03Q  A   1 (-4.3A) 03Q  A   1 (-4.6A) None	0.31A	73.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	3pp0	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 (Homo sapiens)	6 / 9	VAL A 734 LYS A 753 LEU A 785 LEU A 796 LEU A 800 MET A 801	03Q  A   1 (-4.5A) 03Q  A   1 (-4.7A) 03Q  A   1 (-3.1A) 03Q  A   1 (-4.3A) 03Q  A   1 (-4.6A) None	0.55A	73.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	3soa	CALCIUM/CALMODULIN-D EPENDENT PROTEIN KINASE TYPE II SUBUNIT ALPHA WITH A BETA 7 LINKER (Homo sapiens)	5 / 9	LEU A  19 VAL A  27 LEU A  75 LEU A  87 LEU A  91	DB8  A 445 (-3.5A) DB8  A 445 (-4.5A) None None None	0.73A	23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	3w18	AURORA KINASE A (Homo sapiens)	5 / 9	LEU A 139 VAL A 147 LYS A 162 LEU A 196 LEU A 208	N13  A 501 (-3.7A) N13  A 501 ( 4.7A) N13  A 501 (-2.9A) N13  A 501 ( 4.8A) N13  A 501 (-4.9A)	0.52A	23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	4af3	AURORA KINASE B (Homo sapiens)	5 / 9	LEU A  83 VAL A  91 LYS A 106 LEU A 140 LEU A 152	VX6  A 500 (-3.8A) VX6  A 500 ( 4.8A) VX6  A 500 (-3.3A) None None	0.53A	24.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	4ckr	EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1 (Homo sapiens)	5 / 9	LEU A 616 VAL A 624 LYS A 655 LEU A 687 MET A 704	None DI1  A1000 (-4.8A) DI1  A1000 (-3.9A) None None	0.81A	31.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	4eut	SERINE/THREONINE-PRO TEIN KINASE TBK1 (Homo sapiens)	5 / 9	LEU A  15 VAL A  23 LYS A  38 LEU A  70 LEU A  84	BX7  A 401 (-3.7A) BX7  A 401 (-4.4A) BX7  A 401 ( 4.0A) None None	0.73A	23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	4fg8	CALCIUM/CALMODULIN-D EPENDENT PROTEIN KINASE TYPE 1 (Homo sapiens)	6 / 9	LEU A  26 VAL A  34 LYS A  49 LEU A  81 LEU A  93 LEU A  97	ATP  A 401 (-3.8A) ATP  A 401 (-4.1A) ATP  A 401 (-3.0A) None None ATP  A 401 ( 4.8A)	0.62A	25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	4fl3	TYROSINE-PROTEIN KINASE SYK (Homo sapiens)	5 / 9	LEU A 377 VAL A 385 LYS A 402 LEU A 446 LEU A 515	ANP  A 701 ( 4.6A) ANP  A 701 (-4.1A) ANP  A 701 (-2.7A) None None	0.44A	22.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	4hzs	ACTIVATED CDC42 KINASE 1 (Homo sapiens)	6 / 9	LEU A 132 VAL A 140 LYS A 158 LEU A 192 LEU A 207 LEU A 273	None	0.70A	36.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	4id7	ACTIVATED CDC42 KINASE 1 (Homo sapiens)	5 / 9	LEU A 132 VAL A 140 LYS A 158 LEU A 192 LEU A 207	1G0  A 401 ( 4.5A) 1G0  A 401 (-4.4A) 1G0  A 401 (-3.7A) 1G0  A 401 ( 3.8A) 1G0  A 401 ( 4.9A)	0.72A	34.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	4jxf	SERINE/THREONINE-PRO TEIN KINASE PLK4 (Homo sapiens)	5 / 9	LEU A  18 VAL A  26 LYS A  41 LEU A  75 LEU A  87	631  A 301 (-3.4A) 631  A 301 (-4.6A) 631  A 301 (-2.7A) None None	0.67A	25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	4k11	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC (Homo sapiens)	6 / 9	LEU A 273 VAL A 281 LYS A 295 LEU A 325 MET A 341 LEU A 407	0J9  A 601 (-4.0A) 0J9  A 601 (-4.4A) 0J9  A 601 ( 4.7A) None None None	0.76A	26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	4o38	CYCLIN-G-ASSOCIATED KINASE (Homo sapiens)	5 / 9	LEU A  46 VAL A  54 LYS A  69 LEU A 121 LEU A 125	SIN  A 401 ( 3.9A) None None None SIN  A 401 ( 4.8A)	0.59A	21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	4yhj	G PROTEIN-COUPLED RECEPTOR KINASE 4 (Homo sapiens)	5 / 9	LEU A 193 VAL A 201 LEU A 250 LEU A 262 MET A 267	AN2  A 601 ( 4.2A) AN2  A 601 (-4.0A) None None None	0.82A	22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	4yhj	G PROTEIN-COUPLED RECEPTOR KINASE 4 (Homo sapiens)	5 / 9	VAL A 201 LYS A 216 LEU A 250 LEU A 262 MET A 267	AN2  A 601 (-4.0A) AN2  A 601 ( 3.9A) None None None	0.81A	22.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	5j9z	EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens)	7 / 9	LEU A 718 VAL A 726 CYH A 775 LEU A 777 LEU A 788 LEU A 792 MET A 793	6HJ  A1101 ( 4.6A) 6HJ  A1101 ( 4.7A) None None 6HJ  A1101 ( 4.6A) 6HJ  A1101 ( 4.9A) None	0.60A	99.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	5j9z	EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens)	7 / 9	VAL A 726 LYS A 745 CYH A 775 LEU A 777 LEU A 788 LEU A 792 MET A 793	6HJ  A1101 ( 4.7A) 6HJ  A1101 (-4.2A) None None 6HJ  A1101 ( 4.6A) 6HJ  A1101 ( 4.9A) None	0.68A	99.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	5o2c	SERINE/THREONINE-PRO TEIN KINASE WNK3 (Homo sapiens)	5 / 9	LEU A 153 VAL A 161 LEU A 225 LEU A 229 MET A 230	None None None GOL  A 604 ( 4.8A) None	0.83A	26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	5vcx	MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE (Homo sapiens)	5 / 9	LEU A 116 VAL A 124 LEU A 173 LEU A 185 LEU A 189	H8H  A 401 (-3.7A) H8H  A 401 (-4.7A) None H8H  A 401 (-4.3A) None	0.76A	25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	6ccf	CALCIUM/CALMODULIN-D EPENDENT PROTEIN KINASE KINASE 1 (Homo sapiens)	5 / 9	VAL A 142 LYS A 157 LEU A 214 LEU A 228 LEU A 232	H1N  A 501 (-4.4A) H1N  A 501 (-2.8A) None None H1N  A 501 (-4.3A)	0.63A	14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	6cz4	PROTEIN-TYROSINE KINASE 6 (Homo sapiens)	7 / 9	LEU A 197 VAL A 205 LYS A 219 LEU A 250 LEU A 266 MET A 267 LEU A 333	FKY  A9001 (-4.1A) FKY  A9001 ( 4.6A) None None FKY  A9001 (-4.4A) None None	0.83A	16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	1k2p	TYROSINE-PROTEIN KINASE BTK (Homo sapiens)	7 / 12	ALA A 428 LEU A 460 THR A 474 GLY A 480 LEU A 528 ASP A 539 PHE A 540	None	0.74A	34.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	1k2p	TYROSINE-PROTEIN KINASE BTK (Homo sapiens)	8 / 12	VAL A 416 ALA A 428 MET A 449 LEU A 460 GLY A 480 LEU A 528 ASP A 539 PHE A 540	None	0.74A	34.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	1s9i	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2 (Homo sapiens)	6 / 12	VAL A  86 ALA A  99 GLY A 153 LEU A 201 ASP A 212 PHE A 213	ATP  A 535 (-4.1A) ATP  A 535 (-3.6A) ATP  A 535 ( 4.7A) ATP  A 535 (-4.8A) MG  A 536 (-3.3A) 5EA  A1001 (-3.6A)	0.29A	25.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	1snx	TYROSINE-PROTEIN KINASE ITK/TSK (Homo sapiens)	7 / 12	VAL A 377 ALA A 389 LEU A 421 GLY A 441 LEU A 489 ASP A 500 PHE A 501	None	0.70A	33.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	1t46	HOMO SAPIENS V-KIT HARDY-ZUCKERMAN 4 FELINE SARCOMA VIRAL ONCOGENE HOMOLOG (Homo sapiens)	6 / 12	VAL A 603 ALA A 621 LEU A 656 THR A 670 GLY A 676 LEU A 799	STI  A   3 ( 4.6A) STI  A   3 (-3.5A) None STI  A   3 (-3.2A) STI  A   3 ( 3.8A) STI  A   3 (-4.4A)	0.66A	29.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	2dq7	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE FYN (Homo sapiens)	6 / 12	VAL X  25 ALA X  37 LEU X  69 THR X  82 GLY X  88 LEU X 137	STU  X 902 ( 4.8A) STU  X 902 (-3.1A) None STU  X 902 (-4.1A) STU  X 902 (-3.5A) STU  X 902 (-4.4A)	0.66A	36.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	2h8h	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC (Homo sapiens)	10 / 12	VAL A 281 ALA A 293 MET A 314 LEU A 325 THR A 338 GLY A 344 LEU A 393 ASP A 404 PHE A 405 LEU A 407	H8H  A 534 (-4.4A) H8H  A 534 (-3.2A) None None H8H  A 534 (-3.1A) H8H  A 534 (-3.3A) H8H  A 534 (-4.5A) H8H  A 534 (-4.2A) None None	0.84A	23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	2hck	HEMATOPOETIC CELL KINASE HCK (Homo sapiens)	9 / 12	VAL A 281 ALA A 293 MET A 314 LEU A 325 THR A 338 GLY A 344 LEU A 393 ASP A 404 PHE A 405	QUE  A   1 ( 4.8A) QUE  A   1 (-3.5A) None None QUE  A   1 (-3.3A) QUE  A   1 (-3.0A) QUE  A   1 (-4.4A) None None	0.83A	25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	2hck	HEMATOPOETIC CELL KINASE HCK (Homo sapiens)	8 / 12	VAL A 281 MET A 314 THR A 338 GLY A 344 LEU A 393 ASP A 404 PHE A 405 LEU A 407	QUE  A   1 ( 4.8A) None QUE  A   1 (-3.3A) QUE  A   1 (-3.0A) QUE  A   1 (-4.4A) None None None	1.09A	25.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	2hk5	TYROSINE-PROTEIN KINASE HCK (Homo sapiens)	6 / 12	VAL A 259 ALA A 271 LEU A 303 THR A 316 GLY A 322 LEU A 371	1BM  A 499 ( 4.8A) 1BM  A 499 (-3.6A) None 1BM  A 499 (-3.2A) 1BM  A 499 (-3.5A) 1BM  A 499 (-4.4A)	0.59A	34.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	2hz0	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1 (Homo sapiens)	6 / 12	VAL A 256 ALA A 269 LEU A 301 THR A 315 GLY A 321 LEU A 370	GIN  A 600 ( 4.7A) GIN  A 600 (-3.1A) None GIN  A 600 (-3.4A) None GIN  A 600 (-4.7A)	0.63A	34.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	2ozo	TYROSINE-PROTEIN KINASE ZAP-70 (Homo sapiens)	9 / 12	VAL A 352 ALA A 367 MET A 390 LEU A 401 GLY A 418 LEU A 468 ASP A 479 PHE A 480 LEU A 482	ANP  A 615 (-4.5A) ANP  A 615 (-3.3A) None None ANP  A 615 ( 4.0A) ANP  A 615 (-4.7A) MG  A 614 ( 3.2A) None None	1.16A	23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	2ozo	TYROSINE-PROTEIN KINASE ZAP-70 (Homo sapiens)	8 / 12	VAL A 352 ALA A 367 MET A 390 LEU A 401 GLY A 419 LEU A 468 ASP A 479 PHE A 480	ANP  A 615 (-4.5A) ANP  A 615 (-3.3A) None None None ANP  A 615 (-4.7A) MG  A 614 ( 3.2A) None	0.89A	23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	2ozo	TYROSINE-PROTEIN KINASE ZAP-70 (Homo sapiens)	9 / 12	VAL A 352 ALA A 367 MET A 390 LEU A 401 GLY A 420 LEU A 468 ASP A 479 PHE A 480 LEU A 482	ANP  A 615 (-4.5A) ANP  A 615 (-3.3A) None None ANP  A 615 ( 3.9A) ANP  A 615 (-4.7A) MG  A 614 ( 3.2A) None None	0.80A	23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	2qlu	ACTIVIN RECEPTOR TYPE IIB (Homo sapiens)	7 / 12	VAL A 204 ALA A 215 THR A 265 GLY A 271 LEU A 328 ASP A 339 PHE A 340	ADE  A 488 ( 4.9A) ADE  A 488 (-3.2A) ADE  A 488 (-4.3A) ADE  A 488 ( 4.1A) ADE  A 488 (-4.4A) None None	0.90A	23.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	2qob	EPHRIN RECEPTOR (Homo sapiens)	6 / 12	VAL A 635 ALA A 651 LEU A 685 THR A 699 GLY A 705 LEU A 753	BME  A   1 (-4.9A) PTR  A 701 ( 4.7A) None None None None	0.69A	35.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	2r4b	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4 (Homo sapiens)	9 / 12	MET A 772 LEU A 783 THR A 796 GLY A 802 LEU A 850 THR A 860 ASP A 861 PHE A 862 LEU A 864	GW7  A   1 ( 3.8A) GW7  A   1 (-3.9A) GW7  A   1 (-4.0A) GW7  A   1 (-3.6A) GW7  A   1 (-4.2A) GW7  A   1 (-3.5A) GW7  A   1 (-4.1A) GW7  A   1 (-3.8A) GW7  A   1 ( 4.7A)	0.81A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	2r4b	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4 (Homo sapiens)	11 / 12	VAL A 732 ALA A 749 LEU A 783 THR A 796 LEU A 798 GLY A 802 LEU A 850 THR A 860 ASP A 861 PHE A 862 LEU A 864	GW7  A   1 ( 4.8A) GW7  A   1 (-3.3A) GW7  A   1 (-3.9A) GW7  A   1 (-4.0A) GW7  A   1 (-4.5A) GW7  A   1 (-3.6A) GW7  A   1 (-4.2A) GW7  A   1 (-3.5A) GW7  A   1 (-4.1A) GW7  A   1 (-3.8A) GW7  A   1 ( 4.7A)	0.64A	100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	2xk9	CHECKPOINT KINASE 2 (Homo sapiens)	6 / 12	VAL A 234 ALA A 247 LEU A 303 GLY A 307 LEU A 354 THR A 367	XK9  A1511 (-4.8A) XK9  A1511 ( 4.1A) XK9  A1511 (-4.1A) XK9  A1511 ( 3.7A) XK9  A1511 (-4.6A) XK9  A1511 (-3.7A)	0.58A	26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	2y7j	PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, TESTIS/LIVER ISOFORM (Homo sapiens)	6 / 12	VAL A  38 ALA A  51 LEU A  93 LEU A 109 GLY A 113 LEU A 160	None B49  A1294 (-3.2A) None B49  A1294 ( 4.7A) B49  A1294 (-3.6A) B49  A1294 (-4.4A)	0.38A	21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	2y7j	PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, TESTIS/LIVER ISOFORM (Homo sapiens)	7 / 12	VAL A  38 ALA A  51 LEU A 109 GLY A 113 LEU A 160 ASP A 171 PHE A 172	None B49  A1294 (-3.2A) B49  A1294 ( 4.7A) B49  A1294 (-3.6A) B49  A1294 (-4.4A) B49  A1294 (-4.2A) None	0.87A	21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	2z7r	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1 (Homo sapiens)	7 / 12	VAL A  76 ALA A  92 LEU A 127 GLY A 147 LEU A 194 THR A 204 PHE A 206	None STU  A   1 (-3.3A) None STU  A   1 ( 3.9A) STU  A   1 (-4.6A) STU  A   1 (-3.6A) None	0.81A	24.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	3c4f	BASIC FIBROBLAST GROWTH FACTOR RECEPTOR 1 (Homo sapiens)	7 / 12	VAL A 492 ALA A 512 GLY A 567 LEU A 630 ASP A 641 PHE A 642 LEU A 644	None C4F  A   1 (-3.3A) None C4F  A   1 (-4.6A) C4F  A   1 (-4.5A) C4F  A   1 ( 4.5A) None	1.06A	33.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	3d7u	TYROSINE-PROTEIN KINASE CSK (Homo sapiens)	6 / 12	VAL A 209 ALA A 220 LEU A 251 THR A 266 GLY A 272 LEU A 321	None	0.68A	33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	3dtc	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 9 (Homo sapiens)	7 / 12	VAL A 158 ALA A 169 LEU A 206 GLY A 226 LEU A 275 THR A 293 PHE A 295	VIN  A6331 (-4.7A) VIN  A6331 (-3.4A) None VIN  A6331 (-3.4A) VIN  A6331 (-4.5A) VIN  A6331 (-3.6A) None	0.59A	31.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	3fzp	PROTEIN TYROSINE KINASE 2 BETA (Homo sapiens)	6 / 12	VAL A 439 ALA A 455 LEU A 489 LEU A 504 GLY A 508 LEU A 556	AGS  A 999 (-4.6A) AGS  A 999 (-3.6A) None AGS  A 999 (-4.4A) None AGS  A 999 (-4.5A)	0.62A	37.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	3i6u	SERINE/THREONINE-PRO TEIN KINASE CHK2 (Homo sapiens)	8 / 12	VAL A 234 ALA A 247 LEU A 303 GLY A 307 LEU A 354 THR A 367 ASP A 368 PHE A 369	None	0.72A	22.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	3kex	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3 (Homo sapiens)	7 / 12	VAL A 704 LEU A 755 THR A 768 GLY A 774 LEU A 822 ASP A 833 PHE A 834	ANP  A   1 (-3.9A) None ANP  A   1 ( 4.8A) ANP  A   1 ( 4.9A) ANP  A   1 (-4.7A) MG  A1001 ( 3.1A) None	0.53A	58.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	3kul	EPHRIN TYPE-A RECEPTOR 8 (Homo sapiens)	7 / 12	VAL A 649 ALA A 665 THR A 713 GLY A 719 LEU A 767 ASP A 778 PHE A 779	None None None GOL  A 403 (-3.4A) None None None	0.99A	32.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	3lzb	EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens)	11 / 12	ALA A 719 MET A 742 LEU A 753 THR A 766 LEU A 768 GLY A 772 LEU A 820 THR A 830 ASP A 831 PHE A 832 LEU A 834	ITI  A   1 (-2.9A) ITI  A   1 (-3.4A) ITI  A   1 (-3.8A) ITI  A   1 (-3.8A) ITI  A   1 (-4.8A) ITI  A   1 (-3.5A) ITI  A   1 (-4.6A) ITI  A   1 (-3.8A) ITI  A   1 ( 4.6A) ITI  A   1 (-3.6A) None	0.92A	69.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	3lzb	EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens)	11 / 12	VAL A 702 ALA A 719 MET A 742 LEU A 753 THR A 766 LEU A 768 LEU A 820 THR A 830 ASP A 831 PHE A 832 LEU A 834	ITI  A   1 (-4.8A) ITI  A   1 (-2.9A) ITI  A   1 (-3.4A) ITI  A   1 (-3.8A) ITI  A   1 (-3.8A) ITI  A   1 (-4.8A) ITI  A   1 (-4.6A) ITI  A   1 (-3.8A) ITI  A   1 ( 4.6A) ITI  A   1 (-3.6A) None	0.92A	69.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	3pls	MACROPHAGE-STIMULATI NG PROTEIN RECEPTOR (Homo sapiens)	8 / 12	VAL A1096 ALA A1112 MET A1135 LEU A1146 GLY A1167 ASP A1226 PHE A1227 LEU A1229	ANP  A1358 (-4.4A) ANP  A1358 ( 3.8A) None None None MG  A   1 ( 3.2A) None None	0.71A	35.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	3pp0	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 (Homo sapiens)	8 / 12	ALA A 751 LEU A 785 LEU A 800 GLY A 804 LEU A 852 THR A 862 ASP A 863 PHE A 864	03Q  A   1 (-3.1A) 03Q  A   1 (-3.1A) 03Q  A   1 (-4.6A) 03Q  A   1 ( 3.9A) 03Q  A   1 (-4.4A) 03Q  A   1 (-3.3A) 03Q  A   1 (-4.0A) 03Q  A   1 (-4.2A)	0.92A	73.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	3pp0	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 (Homo sapiens)	8 / 12	ALA A 751 LEU A 785 THR A 798 LEU A 800 GLY A 804 LEU A 852 THR A 862 PHE A 864	03Q  A   1 (-3.1A) 03Q  A   1 (-3.1A) 03Q  A   1 (-4.1A) 03Q  A   1 (-4.6A) 03Q  A   1 ( 3.9A) 03Q  A   1 (-4.4A) 03Q  A   1 (-3.3A) 03Q  A   1 (-4.2A)	0.81A	73.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	3pp0	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 (Homo sapiens)	8 / 12	VAL A 734 ALA A 751 LEU A 785 LEU A 800 GLY A 804 LEU A 852 THR A 862 ASP A 863	03Q  A   1 (-4.5A) 03Q  A   1 (-3.1A) 03Q  A   1 (-3.1A) 03Q  A   1 (-4.6A) 03Q  A   1 ( 3.9A) 03Q  A   1 (-4.4A) 03Q  A   1 (-3.3A) 03Q  A   1 (-4.0A)	0.68A	73.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	3pp0	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 (Homo sapiens)	8 / 12	VAL A 734 ALA A 751 LEU A 785 THR A 798 LEU A 800 GLY A 804 LEU A 852 THR A 862	03Q  A   1 (-4.5A) 03Q  A   1 (-3.1A) 03Q  A   1 (-3.1A) 03Q  A   1 (-4.1A) 03Q  A   1 (-4.6A) 03Q  A   1 ( 3.9A) 03Q  A   1 (-4.4A) 03Q  A   1 (-3.3A)	0.40A	73.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	3pp0	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 (Homo sapiens)	8 / 12	VAL A 734 ALA A 751 MET A 774 THR A 798 LEU A 800 GLY A 804 LEU A 852 THR A 862	03Q  A   1 (-4.5A) 03Q  A   1 (-3.1A) 03Q  A   1 (-4.5A) 03Q  A   1 (-4.1A) 03Q  A   1 (-4.6A) 03Q  A   1 ( 3.9A) 03Q  A   1 (-4.4A) 03Q  A   1 (-3.3A)	1.12A	73.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	3wig	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 (Homo sapiens)	6 / 12	VAL A  83 ALA A  96 GLY A 150 LEU A 198 ASP A 209 PHE A 210	ANP  A 401 ( 4.3A) ANP  A 401 (-3.2A) ANP  A 401 ( 4.3A) ANP  A 401 (-4.8A) MG  A 402 (-3.2A) CHU  A 403 (-3.8A)	0.37A	25.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	3wzd	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 (Homo sapiens)	7 / 12	VAL A 848 ALA A 866 GLY A 922 LEU A1035 ASP A1046 PHE A1047 LEU A1049	LEV  A1201 ( 4.9A) LEV  A1201 (-3.5A) LEV  A1201 (-3.6A) LEV  A1201 (-4.8A) GOL  A1210 ( 3.4A) LEV  A1201 (-3.3A) LEV  A1201 ( 4.5A)	0.80A	32.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	3wzd	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 (Homo sapiens)	7 / 12	VAL A 848 ALA A 866 LEU A 889 GLY A 922 LEU A1035 ASP A1046 LEU A1049	LEV  A1201 ( 4.9A) LEV  A1201 (-3.5A) LEV  A1201 ( 4.4A) LEV  A1201 (-3.6A) LEV  A1201 (-4.8A) GOL  A1210 ( 3.4A) LEV  A1201 ( 4.5A)	1.02A	32.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	3zfx	EPHRIN TYPE-B RECEPTOR 1 (Homo sapiens)	6 / 12	VAL A 633 ALA A 649 LEU A 683 THR A 697 GLY A 703 LEU A 751	None	0.65A	35.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	4c02	ACTIVIN RECEPTOR TYPE-1 (Homo sapiens)	6 / 12	VAL A 222 ALA A 233 THR A 283 GLY A 289 LEU A 343 ASP A 354	TAK  A1507 (-4.7A) TAK  A1507 (-3.3A) TAK  A1507 (-3.6A) TAK  A1507 (-3.5A) TAK  A1507 (-4.7A) TAK  A1507 (-3.5A)	0.61A	23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	4e93	TYROSINE-PROTEIN KINASE FES/FPS (Homo sapiens)	6 / 12	VAL A 575 ALA A 588 LEU A 622 LEU A 638 GLY A 642 LEU A 690	GUI  A 901 (-4.5A) GUI  A 901 (-3.4A) None GUI  A 901 (-4.4A) GUI  A 901 (-3.5A) GUI  A 901 (-4.3A)	0.67A	27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	4e93	TYROSINE-PROTEIN KINASE FES/FPS (Homo sapiens)	7 / 12	VAL A 575 ALA A 588 LEU A 638 GLY A 642 LEU A 690 ASP A 701 PHE A 702	GUI  A 901 (-4.5A) GUI  A 901 (-3.4A) GUI  A 901 (-4.4A) GUI  A 901 (-3.5A) GUI  A 901 (-4.3A) GUI  A 901 ( 4.1A) None	0.93A	27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	4fl3	TYROSINE-PROTEIN KINASE SYK (Homo sapiens)	8 / 12	VAL A 385 ALA A 400 MET A 424 GLY A 454 LEU A 501 ASP A 512 PHE A 513 LEU A 515	ANP  A 701 (-4.1A) ANP  A 701 (-3.3A) None ANP  A 701 ( 4.2A) ANP  A 701 (-4.5A) MG  A 702 ( 3.1A) None None	0.61A	22.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	4fod	ALK TYROSINE KINASE RECEPTOR (Homo sapiens)	6 / 12	VAL A1130 ALA A1148 LEU A1198 GLY A1202 LEU A1256 PHE A1271	0UV  A1501 (-4.5A) 0UV  A1501 (-3.4A) 0UV  A1501 ( 4.8A) 0UV  A1501 (-3.6A) 0UV  A1501 (-4.6A) None	0.69A	32.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	4fr4	SERINE/THREONINE-PRO TEIN KINASE 32A (Homo sapiens)	6 / 12	VAL A  37 ALA A  50 LEU A  86 LEU A 102 GLY A 106 THR A 163	STU  A 401 ( 4.9A) STU  A 401 (-3.2A) None STU  A 401 (-4.4A) STU  A 401 ( 3.7A) STU  A 401 (-3.8A)	0.70A	25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	4fr4	SERINE/THREONINE-PRO TEIN KINASE 32A (Homo sapiens)	7 / 12	VAL A  37 ALA A  50 LEU A 102 GLY A 106 LEU A 153 THR A 163 PHE A 165	STU  A 401 ( 4.9A) STU  A 401 (-3.2A) STU  A 401 (-4.4A) STU  A 401 ( 3.7A) STU  A 401 (-4.7A) STU  A 401 (-3.8A) None	0.81A	25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	4hzs	ACTIVATED CDC42 KINASE 1 (Homo sapiens)	9 / 12	VAL A 140 ALA A 156 MET A 181 LEU A 192 GLY A 211 LEU A 259 ASP A 270 PHE A 271 LEU A 273	None	0.53A	36.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	4hzs	ACTIVATED CDC42 KINASE 1 (Homo sapiens)	9 / 12	VAL A 140 ALA A 156 MET A 181 LEU A 192 LEU A 207 GLY A 211 LEU A 259 ASP A 270 LEU A 273	None	0.73A	36.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	4hzs	ACTIVATED CDC42 KINASE 1 (Homo sapiens)	9 / 12	VAL A 140 ALA A 156 MET A 181 LEU A 192 THR A 205 GLY A 211 LEU A 259 ASP A 270 PHE A 271	None	0.69A	36.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	4hzs	ACTIVATED CDC42 KINASE 1 (Homo sapiens)	9 / 12	VAL A 140 ALA A 156 MET A 181 LEU A 192 THR A 205 LEU A 207 GLY A 211 LEU A 259 ASP A 270	None	0.84A	36.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	4id7	ACTIVATED CDC42 KINASE 1 (Homo sapiens)	7 / 12	VAL A 140 ALA A 156 LEU A 192 THR A 205 LEU A 207 GLY A 211 LEU A 259	1G0  A 401 (-4.4A) 1G0  A 401 (-3.6A) 1G0  A 401 ( 3.8A) 1G0  A 401 (-3.2A) 1G0  A 401 ( 4.9A) 1G0  A 401 ( 4.5A) 1G0  A 401 (-4.6A)	0.77A	36.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	4id7	ACTIVATED CDC42 KINASE 1 (Homo sapiens)	7 / 12	VAL A 140 ALA A 156 THR A 205 LEU A 207 GLY A 211 LEU A 259 PHE A 271	1G0  A 401 (-4.4A) 1G0  A 401 (-3.6A) 1G0  A 401 (-3.2A) 1G0  A 401 ( 4.9A) 1G0  A 401 ( 4.5A) 1G0  A 401 (-4.6A) 1G0  A 401 ( 4.8A)	0.97A	36.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	4idt	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 14 (Homo sapiens)	7 / 12	VAL A 414 ALA A 427 LEU A 455 LEU A 471 GLY A 475 LEU A 522 PHE A 535	T28  A 701 (-4.7A) T28  A 701 (-3.0A) None T28  A 701 ( 4.8A) T28  A 701 ( 3.0A) T28  A 701 (-3.9A) None	0.97A	25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	4idt	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 14 (Homo sapiens)	7 / 12	VAL A 414 ALA A 427 LEU A 455 LEU A 471 LEU A 522 ASP A 534 PHE A 535	T28  A 701 (-4.7A) T28  A 701 (-3.0A) None T28  A 701 ( 4.8A) T28  A 701 (-3.9A) T28  A 701 ( 3.4A) None	1.02A	25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	4k11	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC (Homo sapiens)	9 / 12	VAL A 281 ALA A 293 MET A 314 LEU A 325 GLY A 344 LEU A 393 ASP A 404 PHE A 405 LEU A 407	0J9  A 601 (-4.4A) 0J9  A 601 (-3.3A) None None 0J9  A 601 ( 4.1A) 0J9  A 601 (-4.5A) 0J9  A 601 (-3.1A) None None	0.63A	25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	4o38	CYCLIN-G-ASSOCIATED KINASE (Homo sapiens)	7 / 12	VAL A  54 ALA A  67 THR A 123 LEU A 125 GLY A 128 LEU A 180 PHE A 192	None SIN  A 401 ( 3.7A) None SIN  A 401 ( 4.8A) SIN  A 401 (-3.5A) SIN  A 401 ( 4.5A) None	0.77A	24.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	4p2k	EPHRIN TYPE-A RECEPTOR 2 (Homo sapiens)	6 / 12	VAL A 627 ALA A 644 LEU A 678 THR A 692 GLY A 698 LEU A 746	None	0.61A	35.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	4uy9	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 9 (Homo sapiens)	7 / 12	VAL A 158 ALA A 169 GLY A 226 LEU A 275 THR A 293 ASP A 294 PHE A 295	None	0.74A	33.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	4uya	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLK4 (Homo sapiens)	6 / 12	VAL A 138 ALA A 149 GLY A 206 LEU A 270 THR A 288 PHE A 290	AGS  A1438 (-4.4A) AGS  A1438 (-3.4A) None AGS  A1438 (-4.7A) AGS  A1438 ( 4.7A) None	0.62A	34.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	4xey	TYROSINE-PROTEIN KINASE ABL1 (Homo sapiens)	6 / 12	VAL B 275 ALA B 288 LEU B 320 THR B 334 GLY B 340 LEU B 389	1N1  B 601 ( 4.9A) 1N1  B 601 (-3.5A) None 1N1  B 601 (-3.3A) 1N1  B 601 (-3.5A) 1N1  B 601 (-4.3A)	0.63A	29.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	4yc6	CYCLIN-DEPENDENT KINASE 1 (Homo sapiens)	6 / 12	VAL A  18 ALA A  31 LEU A  66 LEU A 135 ASP A 146 PHE A 147	None	0.60A	24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	4yff	SERINE/THREONINE-PRO TEIN KINASE TNNI3K (Homo sapiens)	7 / 12	VAL A 477 ALA A 488 THR A 539 GLY A 545 LEU A 595 ASP A 606 PHE A 607	None 4CV  A 801 (-3.5A) 4CV  A 801 (-2.8A) 4CV  A 801 ( 4.0A) 4CV  A 801 (-4.4A) 4CV  A 801 (-3.5A) None	1.10A	27.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	5a46	FIBROBLAST GROWTH FACTOR RECEPTOR 1 (FMS-RELATED TYROSINE KINASE 2, PFEIFFER SYNDROME), ISOFORM CRA_B (Homo sapiens)	7 / 12	VAL A 492 ALA A 512 GLY A 567 LEU A 630 ASP A 641 PHE A 642 LEU A 644	38O  A1769 (-4.5A) 38O  A1769 (-3.6A) 38O  A1769 (-3.4A) 38O  A1769 (-4.6A) 38O  A1769 (-4.0A) EDO  A1766 (-3.7A) None	0.85A	34.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	5d7a	TRAF2 AND NCK-INTERACTING PROTEIN KINASE (Homo sapiens)	6 / 12	VAL A  39 ALA A  52 GLY A 111 LEU A 160 ASP A 171 PHE A 172	VAL  A  39 (-0.6A) ALA  A  52 (-0.0A) GLY  A 111 (-0.0A) LEU  A 160 (-0.6A) ASP  A 171 ( 0.5A) PHE  A 172 ( 1.3A)	0.55A	25.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	5grn	PLATELET-DERIVED GROWTH FACTOR RECEPTOR ALPHA (Homo sapiens)	6 / 12	VAL A 607 ALA A 625 LEU A 660 THR A 674 GLY A 680 LEU A 825	748  A1001 ( 4.7A) 748  A1001 (-3.7A) None 748  A1001 (-3.2A) 748  A1001 ( 4.0A) 748  A1001 (-4.3A)	0.64A	30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	5j9z	EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens)	7 / 12	ALA A 743 LEU A 792 GLY A 796 LEU A 844 THR A 854 ASP A 855 PHE A 856	6HJ  A1101 (-3.1A) 6HJ  A1101 ( 4.9A) 6HJ  A1101 ( 4.5A) 6HJ  A1101 ( 4.8A) 6HJ  A1101 (-3.9A) 6HJ  A1101 (-4.3A) None	0.89A	77.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	5j9z	EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens)	7 / 12	VAL A 726 ALA A 743 LEU A 777 LEU A 792 GLY A 796 LEU A 844 THR A 854	6HJ  A1101 ( 4.7A) 6HJ  A1101 (-3.1A) None 6HJ  A1101 ( 4.9A) 6HJ  A1101 ( 4.5A) 6HJ  A1101 ( 4.8A) 6HJ  A1101 (-3.9A)	0.65A	77.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	5j9z	EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens)	7 / 12	VAL A 726 ALA A 743 LEU A 792 GLY A 796 LEU A 844 THR A 854 PHE A 856	6HJ  A1101 ( 4.7A) 6HJ  A1101 (-3.1A) 6HJ  A1101 ( 4.9A) 6HJ  A1101 ( 4.5A) 6HJ  A1101 ( 4.8A) 6HJ  A1101 (-3.9A) None	0.85A	77.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	5jzn	SERINE/THREONINE-PRO TEIN KINASE DCLK1 (Homo sapiens)	6 / 12	VAL A 404 ALA A 417 LEU A 451 LEU A 467 GLY A 471 LEU A 518	GUI  A 701 (-4.4A) GUI  A 701 ( 3.9A) None GUI  A 701 ( 4.7A) GUI  A 701 (-3.6A) GUI  A 701 (-4.4A)	0.55A	25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	5kkr	KINASE SUPPRESSOR OF RAS 2 (Homo sapiens)	6 / 12	VAL B 680 ALA B 690 THR B 739 LEU B 741 THR B 802 PHE B 804	6U7  B1001 ( 4.3A) 6U7  B1001 (-3.6A) 6U7  B1001 (-4.0A) 6U7  B1001 (-4.6A) 6U7  B1001 (-3.6A) 6U7  B1001 (-3.8A)	0.65A	27.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	5loh	SERINE/THREONINE-PRO TEIN KINASE GREATWALL,SERINE/THR EONINE-PROTEIN KINASE GREATWALL (Homo sapiens)	7 / 12	VAL A  49 ALA A  60 LEU A  96 GLY A 116 LEU A 163 THR A 173 PHE A 175	None STU  A 901 (-3.3A) None STU  A 901 (-3.5A) STU  A 901 (-4.5A) STU  A 901 (-3.5A) None	0.63A	24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	5vcx	MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE (Homo sapiens)	8 / 12	VAL A 124 ALA A 137 LEU A 173 THR A 187 LEU A 189 GLY A 191 ASP A 251 PHE A 252	H8H  A 401 (-4.7A) H8H  A 401 (-3.3A) None H8H  A 401 (-3.5A) None H8H  A 401 (-4.4A) EDO  A 402 ( 2.9A) None	1.29A	23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	6ao5	SERINE/THREONINE-PRO TEIN KINASE 3 (Homo sapiens)	7 / 12	VAL A  41 ALA A  54 MET A  74 GLY A 105 LEU A 153 ASP A 164 PHE A 165	ANP  A 501 (-4.4A) ANP  A 501 ( 3.7A) None ANP  A 501 ( 4.0A) ANP  A 501 (-4.6A) MG  A 502 ( 3.1A) None	0.60A	26.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	6bql	CALCIUM/CALMODULIN-D EPENDENT PROTEIN KINASE KINASE 2 (Homo sapiens)	6 / 12	VAL A 179 ALA A 192 LEU A 251 LEU A 269 GLY A 273 LEU A 319	BI9  A 501 ( 4.8A) BI9  A 501 (-3.3A) None BI9  A 501 (-4.4A) BI9  A 501 (-3.3A) BI9  A 501 (-4.7A)	0.55A	12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	6ccf	CALCIUM/CALMODULIN-D EPENDENT PROTEIN KINASE KINASE 1 (Homo sapiens)	6 / 12	VAL A 142 ALA A 155 LEU A 214 LEU A 232 GLY A 236 LEU A 282	H1N  A 501 (-4.4A) H1N  A 501 (-3.4A) None H1N  A 501 (-4.3A) H1N  A 501 (-3.6A) H1N  A 501 (-4.8A)	0.42A	13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	6cmj	CALCIUM/CALMODULIN-D EPENDENT PROTEIN KINASE KINASE 2 (Homo sapiens)	6 / 12	VAL A 179 ALA A 192 LEU A 251 LEU A 269 GLY A 273 LEU A 319	F6J  A 501 (-4.6A) F6J  A 501 (-3.4A) None F6J  A 501 ( 4.4A) F6J  A 501 ( 3.7A) F6J  A 501 (-4.5A)	0.64A	10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	6cz4	PROTEIN-TYROSINE KINASE 6 (Homo sapiens)	8 / 12	VAL A 205 ALA A 217 MET A 239 LEU A 250 THR A 264 LEU A 266 GLY A 270 LEU A 319	FKY  A9001 ( 4.6A) FKY  A9001 (-3.3A) FKY  A9001 (-4.2A) None FKY  A9001 (-3.0A) FKY  A9001 (-4.4A) FKY  A9001 (-3.3A) FKY  A9001 ( 4.9A)	0.89A	14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_B_FMMB91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	6cz4	PROTEIN-TYROSINE KINASE 6 (Homo sapiens)	8 / 12	VAL A 205 ALA A 217 MET A 239 LEU A 250 THR A 264 LEU A 266 LEU A 319 LEU A 333	FKY  A9001 ( 4.6A) FKY  A9001 (-3.3A) FKY  A9001 (-4.2A) None FKY  A9001 (-3.0A) FKY  A9001 (-4.4A) FKY  A9001 ( 4.9A) None	0.82A	14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	1s9i	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2 (Homo sapiens)	7 / 12	VAL A  86 ALA A  99 LYS A 101 GLY A 153 LEU A 201 ASP A 212 PHE A 213	ATP  A 535 (-4.1A) ATP  A 535 (-3.6A) ATP  A 535 ( 2.5A) ATP  A 535 ( 4.7A) ATP  A 535 (-4.8A) MG  A 536 (-3.3A) 5EA  A1001 (-3.6A)	0.41A	25.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	1snx	TYROSINE-PROTEIN KINASE ITK/TSK (Homo sapiens)	8 / 12	VAL A 377 ALA A 389 LYS A 391 LEU A 433 GLY A 441 LEU A 489 ASP A 500 PHE A 501	None	0.75A	33.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	1u59	TYROSINE-PROTEIN KINASE ZAP-70 (Homo sapiens)	7 / 12	VAL A 352 ALA A 367 LEU A 412 GLY A 420 LEU A 468 ASP A 479 PHE A 480	STU  A 100 (-4.8A) STU  A 100 (-3.2A) None STU  A 100 (-3.5A) STU  A 100 (-4.5A) STU  A 100 (-3.5A) None	1.06A	35.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	2h8h	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC (Homo sapiens)	9 / 12	VAL A 281 ALA A 293 LYS A 295 MET A 314 THR A 338 GLY A 344 LEU A 393 ASP A 404 LEU A 407	H8H  A 534 (-4.4A) H8H  A 534 (-3.2A) H8H  A 534 (-3.7A) None H8H  A 534 (-3.1A) H8H  A 534 (-3.3A) H8H  A 534 (-4.5A) H8H  A 534 (-4.2A) None	0.93A	23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	2h8h	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC (Homo sapiens)	9 / 12	VAL A 281 ALA A 293 LYS A 295 THR A 338 GLY A 344 LEU A 393 ASP A 404 PHE A 405 LEU A 407	H8H  A 534 (-4.4A) H8H  A 534 (-3.2A) H8H  A 534 (-3.7A) H8H  A 534 (-3.1A) H8H  A 534 (-3.3A) H8H  A 534 (-4.5A) H8H  A 534 (-4.2A) None None	0.89A	23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	2hck	HEMATOPOETIC CELL KINASE HCK (Homo sapiens)	8 / 12	VAL A 281 ALA A 293 LYS A 295 MET A 314 GLY A 344 LEU A 393 ASP A 404 PHE A 405	QUE  A   1 ( 4.8A) QUE  A   1 (-3.5A) None None QUE  A   1 (-3.0A) QUE  A   1 (-4.4A) None None	0.82A	25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	2hck	HEMATOPOETIC CELL KINASE HCK (Homo sapiens)	8 / 12	VAL A 281 ALA A 293 LYS A 295 MET A 314 THR A 338 GLY A 344 LEU A 393 ASP A 404	QUE  A   1 ( 4.8A) QUE  A   1 (-3.5A) None None QUE  A   1 (-3.3A) QUE  A   1 (-3.0A) QUE  A   1 (-4.4A) None	0.70A	25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	2hck	HEMATOPOETIC CELL KINASE HCK (Homo sapiens)	8 / 12	VAL A 281 LYS A 295 MET A 314 GLY A 344 LEU A 393 ASP A 404 PHE A 405 LEU A 407	QUE  A   1 ( 4.8A) None None QUE  A   1 (-3.0A) QUE  A   1 (-4.4A) None None None	1.13A	25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	2hck	HEMATOPOETIC CELL KINASE HCK (Homo sapiens)	8 / 12	VAL A 281 LYS A 295 MET A 314 THR A 338 GLY A 344 LEU A 393 ASP A 404 LEU A 407	QUE  A   1 ( 4.8A) None None QUE  A   1 (-3.3A) QUE  A   1 (-3.0A) QUE  A   1 (-4.4A) None None	0.99A	25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	2ozo	TYROSINE-PROTEIN KINASE ZAP-70 (Homo sapiens)	8 / 12	VAL A 352 ALA A 367 LYS A 369 MET A 390 GLY A 419 ASP A 479 PHE A 480 LEU A 482	ANP  A 615 (-4.5A) ANP  A 615 (-3.3A) ANP  A 615 (-3.1A) None None MG  A 614 ( 3.2A) None None	0.97A	23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	2ozo	TYROSINE-PROTEIN KINASE ZAP-70 (Homo sapiens)	9 / 12	VAL A 352 ALA A 367 LYS A 369 MET A 390 LEU A 412 GLY A 418 ASP A 479 PHE A 480 LEU A 482	ANP  A 615 (-4.5A) ANP  A 615 (-3.3A) ANP  A 615 (-3.1A) None None ANP  A 615 ( 4.0A) MG  A 614 ( 3.2A) None None	1.05A	23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	2ozo	TYROSINE-PROTEIN KINASE ZAP-70 (Homo sapiens)	9 / 12	VAL A 352 ALA A 367 LYS A 369 MET A 390 LEU A 412 GLY A 420 ASP A 479 PHE A 480 LEU A 482	ANP  A 615 (-4.5A) ANP  A 615 (-3.3A) ANP  A 615 (-3.1A) None None ANP  A 615 ( 3.9A) MG  A 614 ( 3.2A) None None	1.04A	23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	2ozo	TYROSINE-PROTEIN KINASE ZAP-70 (Homo sapiens)	8 / 12	VAL A 352 ALA A 367 MET A 390 GLY A 419 LEU A 468 ASP A 479 PHE A 480 LEU A 482	ANP  A 615 (-4.5A) ANP  A 615 (-3.3A) None None ANP  A 615 (-4.7A) MG  A 614 ( 3.2A) None None	1.08A	23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	2ozo	TYROSINE-PROTEIN KINASE ZAP-70 (Homo sapiens)	9 / 12	VAL A 352 ALA A 367 MET A 390 LEU A 412 GLY A 418 LEU A 468 ASP A 479 PHE A 480 LEU A 482	ANP  A 615 (-4.5A) ANP  A 615 (-3.3A) None None ANP  A 615 ( 4.0A) ANP  A 615 (-4.7A) MG  A 614 ( 3.2A) None None	1.28A	23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	2ozo	TYROSINE-PROTEIN KINASE ZAP-70 (Homo sapiens)	9 / 12	VAL A 352 ALA A 367 MET A 390 LEU A 412 GLY A 420 LEU A 468 ASP A 479 PHE A 480 LEU A 482	ANP  A 615 (-4.5A) ANP  A 615 (-3.3A) None None ANP  A 615 ( 3.9A) ANP  A 615 (-4.7A) MG  A 614 ( 3.2A) None None	0.96A	23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	2qlu	ACTIVIN RECEPTOR TYPE IIB (Homo sapiens)	7 / 12	VAL A 204 ALA A 215 LEU A 263 GLY A 271 LEU A 328 ASP A 339 PHE A 340	ADE  A 488 ( 4.9A) ADE  A 488 (-3.2A) None ADE  A 488 ( 4.1A) ADE  A 488 (-4.4A) None None	0.93A	23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	2qlu	ACTIVIN RECEPTOR TYPE IIB (Homo sapiens)	7 / 12	VAL A 204 ALA A 215 LYS A 217 LEU A 263 GLY A 271 LEU A 328 ASP A 339	ADE  A 488 ( 4.9A) ADE  A 488 (-3.2A) None None ADE  A 488 ( 4.1A) ADE  A 488 (-4.4A) None	0.82A	23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	2qlu	ACTIVIN RECEPTOR TYPE IIB (Homo sapiens)	7 / 12	VAL A 204 ALA A 215 LYS A 217 THR A 265 GLY A 271 LEU A 328 ASP A 339	ADE  A 488 ( 4.9A) ADE  A 488 (-3.2A) None ADE  A 488 (-4.3A) ADE  A 488 ( 4.1A) ADE  A 488 (-4.4A) None	0.75A	23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	2qlu	ACTIVIN RECEPTOR TYPE IIB (Homo sapiens)	7 / 12	VAL A 204 ALA A 215 THR A 265 GLY A 271 LEU A 328 ASP A 339 PHE A 340	ADE  A 488 ( 4.9A) ADE  A 488 (-3.2A) ADE  A 488 (-4.3A) ADE  A 488 ( 4.1A) ADE  A 488 (-4.4A) None None	0.87A	23.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	2r4b	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4 (Homo sapiens)	7 / 12	MET A 772 GLY A 802 LEU A 850 THR A 860 ASP A 861 PHE A 862 LEU A 864	GW7  A   1 ( 3.8A) GW7  A   1 (-3.6A) GW7  A   1 (-4.2A) GW7  A   1 (-3.5A) GW7  A   1 (-4.1A) GW7  A   1 (-3.8A) GW7  A   1 ( 4.7A)	1.12A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	2r4b	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4 (Homo sapiens)	11 / 12	VAL A 732 ALA A 749 LYS A 751 LEU A 794 THR A 796 GLY A 802 LEU A 850 THR A 860 ASP A 861 PHE A 862 LEU A 864	GW7  A   1 ( 4.8A) GW7  A   1 (-3.3A) GW7  A   1 (-3.9A) GW7  A   1 (-4.1A) GW7  A   1 (-4.0A) GW7  A   1 (-3.6A) GW7  A   1 (-4.2A) GW7  A   1 (-3.5A) GW7  A   1 (-4.1A) GW7  A   1 (-3.8A) GW7  A   1 ( 4.7A)	0.68A	100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	2y7j	PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, TESTIS/LIVER ISOFORM (Homo sapiens)	7 / 12	VAL A  38 ALA A  51 LYS A  53 GLY A 113 LEU A 160 ASP A 171 PHE A 172	None B49  A1294 (-3.2A) None B49  A1294 (-3.6A) B49  A1294 (-4.4A) B49  A1294 (-4.2A) None	1.08A	21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	2z7r	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1 (Homo sapiens)	7 / 12	VAL A  76 ALA A  92 LEU A 139 GLY A 147 LEU A 194 THR A 204 PHE A 206	None STU  A   1 (-3.3A) None STU  A   1 ( 3.9A) STU  A   1 (-4.6A) STU  A   1 (-3.6A) None	0.77A	24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	2z7r	RIBOSOMAL PROTEIN S6 KINASE ALPHA-1 (Homo sapiens)	7 / 12	VAL A  76 ALA A  92 LYS A  94 LEU A 139 GLY A 147 LEU A 194 THR A 204	None STU  A   1 (-3.3A) STU  A   1 (-2.8A) None STU  A   1 ( 3.9A) STU  A   1 (-4.6A) STU  A   1 (-3.6A)	0.84A	24.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	3c4f	BASIC FIBROBLAST GROWTH FACTOR RECEPTOR 1 (Homo sapiens)	7 / 12	VAL A 492 ALA A 512 GLY A 567 LEU A 630 ASP A 641 PHE A 642 LEU A 644	None C4F  A   1 (-3.3A) None C4F  A   1 (-4.6A) C4F  A   1 (-4.5A) C4F  A   1 ( 4.5A) None	1.19A	33.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	3dtc	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 9 (Homo sapiens)	7 / 12	VAL A 158 ALA A 169 LEU A 218 GLY A 226 LEU A 275 THR A 293 PHE A 295	VIN  A6331 (-4.7A) VIN  A6331 (-3.4A) None VIN  A6331 (-3.4A) VIN  A6331 (-4.5A) VIN  A6331 (-3.6A) None	0.39A	31.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	3i6u	SERINE/THREONINE-PRO TEIN KINASE CHK2 (Homo sapiens)	7 / 12	VAL A 234 ALA A 247 GLY A 307 LEU A 354 THR A 367 ASP A 368 PHE A 369	None	0.72A	22.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	3kex	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3 (Homo sapiens)	8 / 12	VAL A 704 LYS A 723 LEU A 766 THR A 768 GLY A 774 LEU A 822 ASP A 833 PHE A 834	ANP  A   1 (-3.9A) ANP  A   1 (-3.4A) None ANP  A   1 ( 4.8A) ANP  A   1 ( 4.9A) ANP  A   1 (-4.7A) MG  A1001 ( 3.1A) None	0.61A	58.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	3kul	EPHRIN TYPE-A RECEPTOR 8 (Homo sapiens)	7 / 12	VAL A 649 ALA A 665 THR A 713 GLY A 719 LEU A 767 ASP A 778 PHE A 779	None None None GOL  A 403 (-3.4A) None None None	0.96A	32.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	3lm5	SERINE/THREONINE-PRO TEIN KINASE 17B (Homo sapiens)	8 / 12	VAL A  47 ALA A  60 LYS A  62 LEU A 108 GLY A 116 LEU A 165 ASP A 179 PHE A 180	QUE  A   1 ( 4.6A) QUE  A   1 (-3.2A) QUE  A   1 (-4.1A) None None None QUE  A   1 (-2.9A) None	0.97A	24.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	3lzb	EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens)	8 / 12	ALA A 719 LEU A 764 GLY A 772 LEU A 820 THR A 830 ASP A 831 PHE A 832 LEU A 834	ITI  A   1 (-2.9A) ITI  A   1 ( 4.2A) ITI  A   1 (-3.5A) ITI  A   1 (-4.6A) ITI  A   1 (-3.8A) ITI  A   1 ( 4.6A) ITI  A   1 (-3.6A) None	0.88A	69.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	3lzb	EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens)	8 / 12	ALA A 719 LEU A 764 THR A 766 GLY A 772 LEU A 820 THR A 830 ASP A 831 PHE A 832	ITI  A   1 (-2.9A) ITI  A   1 ( 4.2A) ITI  A   1 (-3.8A) ITI  A   1 (-3.5A) ITI  A   1 (-4.6A) ITI  A   1 (-3.8A) ITI  A   1 ( 4.6A) ITI  A   1 (-3.6A)	0.91A	69.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	3lzb	EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens)	8 / 12	ALA A 719 MET A 742 GLY A 772 LEU A 820 THR A 830 ASP A 831 PHE A 832 LEU A 834	ITI  A   1 (-2.9A) ITI  A   1 (-3.4A) ITI  A   1 (-3.5A) ITI  A   1 (-4.6A) ITI  A   1 (-3.8A) ITI  A   1 ( 4.6A) ITI  A   1 (-3.6A) None	1.07A	69.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	3lzb	EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens)	8 / 12	ALA A 719 MET A 742 THR A 766 GLY A 772 LEU A 820 THR A 830 ASP A 831 PHE A 832	ITI  A   1 (-2.9A) ITI  A   1 (-3.4A) ITI  A   1 (-3.8A) ITI  A   1 (-3.5A) ITI  A   1 (-4.6A) ITI  A   1 (-3.8A) ITI  A   1 ( 4.6A) ITI  A   1 (-3.6A)	1.03A	69.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	3lzb	EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens)	8 / 12	VAL A 702 ALA A 719 LEU A 764 LEU A 820 THR A 830 ASP A 831 PHE A 832 LEU A 834	ITI  A   1 (-4.8A) ITI  A   1 (-2.9A) ITI  A   1 ( 4.2A) ITI  A   1 (-4.6A) ITI  A   1 (-3.8A) ITI  A   1 ( 4.6A) ITI  A   1 (-3.6A) None	0.84A	69.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	3lzb	EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens)	8 / 12	VAL A 702 ALA A 719 LEU A 764 THR A 766 LEU A 820 THR A 830 ASP A 831 PHE A 832	ITI  A   1 (-4.8A) ITI  A   1 (-2.9A) ITI  A   1 ( 4.2A) ITI  A   1 (-3.8A) ITI  A   1 (-4.6A) ITI  A   1 (-3.8A) ITI  A   1 ( 4.6A) ITI  A   1 (-3.6A)	0.87A	69.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	3lzb	EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens)	7 / 12	VAL A 702 ALA A 719 LYS A 721 LEU A 764 ASP A 831 PHE A 832 LEU A 834	ITI  A   1 (-4.8A) ITI  A   1 (-2.9A) ITI  A   1 (-2.6A) ITI  A   1 ( 4.2A) ITI  A   1 ( 4.6A) ITI  A   1 (-3.6A) None	1.03A	69.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	3lzb	EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens)	7 / 12	VAL A 702 ALA A 719 LYS A 721 LEU A 764 THR A 766 ASP A 831 PHE A 832	ITI  A   1 (-4.8A) ITI  A   1 (-2.9A) ITI  A   1 (-2.6A) ITI  A   1 ( 4.2A) ITI  A   1 (-3.8A) ITI  A   1 ( 4.6A) ITI  A   1 (-3.6A)	1.04A	69.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	3lzb	EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens)	8 / 12	VAL A 702 ALA A 719 MET A 742 LEU A 820 THR A 830 ASP A 831 PHE A 832 LEU A 834	ITI  A   1 (-4.8A) ITI  A   1 (-2.9A) ITI  A   1 (-3.4A) ITI  A   1 (-4.6A) ITI  A   1 (-3.8A) ITI  A   1 ( 4.6A) ITI  A   1 (-3.6A) None	1.04A	69.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	3lzb	EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens)	8 / 12	VAL A 702 ALA A 719 MET A 742 THR A 766 LEU A 820 THR A 830 ASP A 831 PHE A 832	ITI  A   1 (-4.8A) ITI  A   1 (-2.9A) ITI  A   1 (-3.4A) ITI  A   1 (-3.8A) ITI  A   1 (-4.6A) ITI  A   1 (-3.8A) ITI  A   1 ( 4.6A) ITI  A   1 (-3.6A)	1.00A	69.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	3mdy	BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B (Homo sapiens)	7 / 12	VAL A 218 ALA A 229 LEU A 277 THR A 279 GLY A 285 LEU A 339 ASP A 350	LDN  A   1 ( 4.8A) LDN  A   1 (-3.6A) None LDN  A   1 (-3.8A) LDN  A   1 (-3.3A) LDN  A   1 (-4.5A) LDN  A   1 (-3.9A)	0.88A	25.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	3pls	MACROPHAGE-STIMULATI NG PROTEIN RECEPTOR (Homo sapiens)	8 / 12	VAL A1096 ALA A1112 LYS A1114 MET A1135 GLY A1167 ASP A1226 PHE A1227 LEU A1229	ANP  A1358 (-4.4A) ANP  A1358 ( 3.8A) ANP  A1358 (-3.2A) None None MG  A   1 ( 3.2A) None None	0.80A	35.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	3pp0	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 (Homo sapiens)	8 / 12	VAL A 734 ALA A 751 LYS A 753 LEU A 796 GLY A 804 LEU A 852 THR A 862 ASP A 863	03Q  A   1 (-4.5A) 03Q  A   1 (-3.1A) 03Q  A   1 (-4.7A) 03Q  A   1 (-4.3A) 03Q  A   1 ( 3.9A) 03Q  A   1 (-4.4A) 03Q  A   1 (-3.3A) 03Q  A   1 (-4.0A)	0.87A	73.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	3pp0	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 (Homo sapiens)	8 / 12	VAL A 734 ALA A 751 LYS A 753 LEU A 796 THR A 798 GLY A 804 LEU A 852 THR A 862	03Q  A   1 (-4.5A) 03Q  A   1 (-3.1A) 03Q  A   1 (-4.7A) 03Q  A   1 (-4.3A) 03Q  A   1 (-4.1A) 03Q  A   1 ( 3.9A) 03Q  A   1 (-4.4A) 03Q  A   1 (-3.3A)	0.64A	73.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	3q4t	ACTIVIN RECEPTOR TYPE-2A (Homo sapiens)	8 / 12	VAL A 206 ALA A 217 LEU A 265 THR A 267 GLY A 273 LEU A 329 ASP A 340 PHE A 341	TAK  A   2 ( 4.9A) TAK  A   2 (-3.5A) None TAK  A   2 (-3.5A) TAK  A   2 (-3.6A) TAK  A   2 (-4.6A) None None	1.00A	23.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	3tt0	BASIC FIBROBLAST GROWTH FACTOR RECEPTOR 1 (Homo sapiens)	7 / 12	VAL A 492 ALA A 512 LYS A 514 GLY A 567 LEU A 630 ASP A 641 PHE A 642	07J  A   1 (-4.0A) 07J  A   1 (-3.5A) 07J  A   1 (-4.5A) 07J  A   1 (-3.7A) 07J  A   1 ( 4.4A) 07J  A   1 (-4.7A) 07J  A   1 ( 4.6A)	1.01A	31.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	3wig	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 (Homo sapiens)	7 / 12	VAL A  83 ALA A  96 LYS A  98 GLY A 150 LEU A 198 ASP A 209 PHE A 210	ANP  A 401 ( 4.3A) ANP  A 401 (-3.2A) ANP  A 401 (-2.7A) ANP  A 401 ( 4.3A) ANP  A 401 (-4.8A) MG  A 402 (-3.2A) CHU  A 403 (-3.8A)	0.56A	25.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	3wzd	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 (Homo sapiens)	7 / 12	VAL A 848 ALA A 866 GLY A 922 LEU A1035 ASP A1046 PHE A1047 LEU A1049	LEV  A1201 ( 4.9A) LEV  A1201 (-3.5A) LEV  A1201 (-3.6A) LEV  A1201 (-4.8A) GOL  A1210 ( 3.4A) LEV  A1201 (-3.3A) LEV  A1201 ( 4.5A)	0.85A	32.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	4c02	ACTIVIN RECEPTOR TYPE-1 (Homo sapiens)	7 / 12	VAL A 222 ALA A 233 LYS A 235 LEU A 281 GLY A 289 LEU A 343 ASP A 354	TAK  A1507 (-4.7A) TAK  A1507 (-3.3A) TAK  A1507 ( 4.5A) None TAK  A1507 (-3.5A) TAK  A1507 (-4.7A) TAK  A1507 (-3.5A)	0.84A	23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	4c02	ACTIVIN RECEPTOR TYPE-1 (Homo sapiens)	7 / 12	VAL A 222 ALA A 233 LYS A 235 THR A 283 GLY A 289 LEU A 343 ASP A 354	TAK  A1507 (-4.7A) TAK  A1507 (-3.3A) TAK  A1507 ( 4.5A) TAK  A1507 (-3.6A) TAK  A1507 (-3.5A) TAK  A1507 (-4.7A) TAK  A1507 (-3.5A)	0.71A	23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	4fl3	TYROSINE-PROTEIN KINASE SYK (Homo sapiens)	9 / 12	VAL A 385 ALA A 400 LYS A 402 LEU A 446 GLY A 454 LEU A 501 ASP A 512 PHE A 513 LEU A 515	ANP  A 701 (-4.1A) ANP  A 701 (-3.3A) ANP  A 701 (-2.7A) None ANP  A 701 ( 4.2A) ANP  A 701 (-4.5A) MG  A 702 ( 3.1A) None None	0.82A	22.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	4hzs	ACTIVATED CDC42 KINASE 1 (Homo sapiens)	8 / 12	VAL A 140 ALA A 156 LYS A 158 GLY A 211 LEU A 259 ASP A 270 PHE A 271 LEU A 273	None	0.65A	36.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	4hzs	ACTIVATED CDC42 KINASE 1 (Homo sapiens)	9 / 12	VAL A 140 ALA A 156 MET A 181 THR A 205 GLY A 211 LEU A 259 ASP A 270 PHE A 271 LEU A 273	None	0.85A	36.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	4jxf	SERINE/THREONINE-PRO TEIN KINASE PLK4 (Homo sapiens)	7 / 12	VAL A  26 ALA A  39 LYS A  41 LEU A  87 GLY A  95 LEU A 143 PHE A 155	631  A 301 (-4.6A) 631  A 301 (-3.3A) 631  A 301 (-2.7A) None 631  A 301 ( 3.7A) 631  A 301 (-4.0A) None	0.74A	25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	4k11	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC (Homo sapiens)	8 / 12	VAL A 281 ALA A 293 LYS A 295 GLY A 344 LEU A 393 ASP A 404 PHE A 405 LEU A 407	0J9  A 601 (-4.4A) 0J9  A 601 (-3.3A) 0J9  A 601 ( 4.7A) 0J9  A 601 ( 4.1A) 0J9  A 601 (-4.5A) 0J9  A 601 (-3.1A) None None	0.67A	25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	4k11	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC (Homo sapiens)	7 / 12	VAL A 281 ALA A 293 MET A 314 GLY A 344 LEU A 393 ASP A 404 PHE A 405	0J9  A 601 (-4.4A) 0J9  A 601 (-3.3A) None 0J9  A 601 ( 4.1A) 0J9  A 601 (-4.5A) 0J9  A 601 (-3.1A) None	0.60A	25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	4o38	CYCLIN-G-ASSOCIATED KINASE (Homo sapiens)	7 / 12	VAL A  54 ALA A  67 LEU A 121 THR A 123 GLY A 128 LEU A 180 PHE A 192	None SIN  A 401 ( 3.7A) None None SIN  A 401 (-3.5A) SIN  A 401 ( 4.5A) None	0.77A	24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	4o38	CYCLIN-G-ASSOCIATED KINASE (Homo sapiens)	7 / 12	VAL A  54 ALA A  67 LYS A  69 LEU A 121 THR A 123 GLY A 128 LEU A 180	None SIN  A 401 ( 3.7A) None None None SIN  A 401 (-3.5A) SIN  A 401 ( 4.5A)	0.84A	24.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	4uy9	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 9 (Homo sapiens)	7 / 12	VAL A 158 ALA A 169 GLY A 226 LEU A 275 THR A 293 ASP A 294 PHE A 295	None	0.69A	33.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	4uy9	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 9 (Homo sapiens)	7 / 12	VAL A 158 ALA A 169 LEU A 218 GLY A 226 LEU A 275 THR A 293 PHE A 295	None	0.84A	33.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	4uy9	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 9 (Homo sapiens)	7 / 12	VAL A 158 ALA A 169 LYS A 171 LEU A 218 GLY A 226 LEU A 275 THR A 293	None	1.23A	33.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	4uya	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLK4 (Homo sapiens)	7 / 12	VAL A 138 ALA A 149 LEU A 198 GLY A 206 LEU A 270 THR A 288 PHE A 290	AGS  A1438 (-4.4A) AGS  A1438 (-3.4A) None None AGS  A1438 (-4.7A) AGS  A1438 ( 4.7A) None	0.61A	34.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	4wb7	DNAJ HOMOLOG SUBFAMILY B MEMBER 1,CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA (Homo sapiens)	7 / 12	VAL A 112 ALA A 125 LYS A 127 GLY A 181 LEU A 228 THR A 238 PHE A 240	ATP  A 501 (-4.0A) ATP  A 501 (-3.4A) ATP  A 501 (-2.6A) None ATP  A 501 (-4.5A) ATP  A 501 (-3.1A) None	1.23A	21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	4yc6	CYCLIN-DEPENDENT KINASE 1 (Homo sapiens)	7 / 12	VAL A  18 ALA A  31 LEU A  78 LEU A 135 ASP A 146 PHE A 147 LEU A 149	None	0.73A	24.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	5a46	FIBROBLAST GROWTH FACTOR RECEPTOR 1 (FMS-RELATED TYROSINE KINASE 2, PFEIFFER SYNDROME), ISOFORM CRA_B (Homo sapiens)	7 / 12	VAL A 492 ALA A 512 GLY A 567 LEU A 630 ASP A 641 PHE A 642 LEU A 644	38O  A1769 (-4.5A) 38O  A1769 (-3.6A) 38O  A1769 (-3.4A) 38O  A1769 (-4.6A) 38O  A1769 (-4.0A) EDO  A1766 (-3.7A) None	0.99A	34.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	5a46	FIBROBLAST GROWTH FACTOR RECEPTOR 1 (FMS-RELATED TYROSINE KINASE 2, PFEIFFER SYNDROME), ISOFORM CRA_B (Homo sapiens)	7 / 12	VAL A 492 ALA A 512 LYS A 514 GLY A 567 LEU A 630 ASP A 641 LEU A 644	38O  A1769 (-4.5A) 38O  A1769 (-3.6A) 38O  A1769 ( 3.1A) 38O  A1769 (-3.4A) 38O  A1769 (-4.6A) 38O  A1769 (-4.0A) None	1.11A	34.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	5ci7	SERINE/THREONINE-PRO TEIN KINASE ULK1 (Homo sapiens)	7 / 12	VAL A  30 ALA A  44 LEU A  90 GLY A  98 LEU A 145 ASP A 165 PHE A 166	51W  A 401 ( 4.3A) 51W  A 401 (-3.4A) None 51W  A 401 (-3.7A) 51W  A 401 (-4.5A) GOL  A 404 (-3.2A) None	0.90A	26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	5ci7	SERINE/THREONINE-PRO TEIN KINASE ULK1 (Homo sapiens)	7 / 12	VAL A  30 ALA A  44 LYS A  46 LEU A  90 GLY A  98 LEU A 145 ASP A 165	51W  A 401 ( 4.3A) 51W  A 401 (-3.4A) GOL  A 404 ( 3.1A) None 51W  A 401 (-3.7A) 51W  A 401 (-4.5A) GOL  A 404 (-3.2A)	1.06A	26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	5d7a	TRAF2 AND NCK-INTERACTING PROTEIN KINASE (Homo sapiens)	7 / 12	VAL A  39 ALA A  52 LEU A 103 GLY A 111 LEU A 160 ASP A 171 PHE A 172	VAL  A  39 (-0.6A) ALA  A  52 (-0.0A) LEU  A 103 ( 0.6A) GLY  A 111 (-0.0A) LEU  A 160 (-0.6A) ASP  A 171 ( 0.5A) PHE  A 172 ( 1.3A)	0.76A	25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	5e8y	TGF-BETA RECEPTOR TYPE-2 (Homo sapiens)	7 / 12	VAL A 258 ALA A 275 LEU A 323 THR A 325 GLY A 331 LEU A 386 PHE A 398	STU  A 601 (-4.0A) STU  A 601 (-3.1A) None STU  A 601 ( 3.7A) STU  A 601 (-3.5A) STU  A 601 (-3.9A) None	0.80A	25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	5e8y	TGF-BETA RECEPTOR TYPE-2 (Homo sapiens)	7 / 12	VAL A 258 ALA A 275 LYS A 277 LEU A 323 THR A 325 GLY A 331 LEU A 386	STU  A 601 (-4.0A) STU  A 601 (-3.1A) STU  A 601 (-2.4A) None STU  A 601 ( 3.7A) STU  A 601 (-3.5A) STU  A 601 (-3.9A)	0.71A	25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	5j5t	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 3 (Homo sapiens)	7 / 12	VAL A  30 ALA A  43 MET A  64 GLY A  96 LEU A 143 ASP A 154 PHE A 155	6G2  A 901 ( 4.9A) 6G2  A 901 (-3.2A) None 6G2  A 901 (-3.6A) 6G2  A 901 (-4.7A) 6G2  A 901 (-3.4A) None	1.13A	25.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	5j9z	EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens)	7 / 12	VAL A 726 ALA A 743 LYS A 745 GLY A 796 LEU A 844 THR A 854 PHE A 856	6HJ  A1101 ( 4.7A) 6HJ  A1101 (-3.1A) 6HJ  A1101 (-4.2A) 6HJ  A1101 ( 4.5A) 6HJ  A1101 ( 4.8A) 6HJ  A1101 (-3.9A) None	1.00A	77.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	5j9z	EPIDERMAL GROWTH FACTOR RECEPTOR (Homo sapiens)	7 / 12	VAL A 726 ALA A 743 LYS A 745 LEU A 788 GLY A 796 LEU A 844 THR A 854	6HJ  A1101 ( 4.7A) 6HJ  A1101 (-3.1A) 6HJ  A1101 (-4.2A) 6HJ  A1101 ( 4.6A) 6HJ  A1101 ( 4.5A) 6HJ  A1101 ( 4.8A) 6HJ  A1101 (-3.9A)	0.81A	77.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	5kbr	SERINE/THREONINE-PRO TEIN KINASE PAK 1 (Homo sapiens)	7 / 12	VAL A 284 ALA A 297 LYS A 299 GLY A 350 LEU A 396 THR A 406 PHE A 408	IPW  A 601 (-4.2A) IPW  A 601 (-3.5A) IPW  A 601 (-4.5A) IPW  A 601 ( 3.8A) IPW  A 601 (-4.5A) IPW  A 601 (-3.7A) None	0.82A	24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	5loh	SERINE/THREONINE-PRO TEIN KINASE GREATWALL,SERINE/THR EONINE-PROTEIN KINASE GREATWALL (Homo sapiens)	7 / 12	VAL A  49 ALA A  60 LEU A 108 GLY A 116 LEU A 163 THR A 173 PHE A 175	None STU  A 901 (-3.3A) None STU  A 901 (-3.5A) STU  A 901 (-4.5A) STU  A 901 (-3.5A) None	0.55A	24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	6ao5	SERINE/THREONINE-PRO TEIN KINASE 3 (Homo sapiens)	7 / 12	VAL A  41 ALA A  54 LYS A  56 GLY A 105 LEU A 153 ASP A 164 PHE A 165	ANP  A 501 (-4.4A) ANP  A 501 ( 3.7A) ANP  A 501 (-2.4A) ANP  A 501 ( 4.0A) ANP  A 501 (-4.6A) MG  A 502 ( 3.1A) None	0.55A	26.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BBT_D_FMMD91_1 (RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4)	6bfn	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1 (Homo sapiens)	7 / 12	VAL A 226 ALA A 237 LEU A 286 GLY A 294 LEU A 347 ASP A 358 PHE A 359	None DL1  A 601 (-3.4A) None DL1  A 601 (-3.5A) DL1  A 601 (-3.9A) DL1  A 601 (-3.1A) None	0.86A	17.75