POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R94_A_FLRA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		1b41 ACETYLCHOLINESTERASE
(Homo
sapiens)		5 / 12LEU A 513
ASN A 490
TYR A 426
TRP A 480
PRO A 492
None
1.44A20.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R94_A_FLRA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens)		6 / 12LEU A  54
TYR A  55
HIS A 117
MET A 120
ASN A 167
PRO A 318
None
NAP  A1001 (-4.7A)
NAP  A1001 (-4.4A)
None
NAP  A1001 (-3.1A)
None
0.50A84.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R94_A_FLRA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		2ipj ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2
(Homo
sapiens)		5 / 12TYR A  55
HIS A 117
ASN A 167
TYR A 216
PRO A 318
FFA  A 325 ( 4.3A)
FFA  A 325 ( 3.8A)
NAP  A   1 (-3.1A)
NAP  A   1 (-3.2A)
None
0.37A86.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R94_A_FLRA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		2is7 ALDOSE REDUCTASE
(Homo
sapiens)		5 / 12TYR A  48
HIS A 110
ASN A 160
TYR A 209
PRO A 310
2CL  A 317 ( 4.5A)
2CL  A 317 ( 3.8A)
NAP  A 316 (-3.4A)
NAP  A 316 (-3.2A)
None
0.48A48.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R94_A_FLRA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		3cav 3-OXO-5-BETA-STEROID
4-DEHYDROGENASE
(Homo
sapiens)		5 / 12TYR A  58
MET A 123
ASN A 170
TYR A 219
PRO A 321
CI2  A 328 ( 4.5A)
None
NAP  A 327 (-3.6A)
NAP  A 327 (-3.4A)
None
0.53A55.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R94_A_FLRA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		3wyr KILLER CELL
IMMUNOGLOBULIN-LIKE
RECEPTOR 2DL4
(Homo
sapiens)		5 / 12HIS A  80
SER A  81
PHE A  34
PHE A  77
TYR A  30
None
1.40A20.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R94_A_FLRA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens)		5 / 12TYR X  49
HIS X 111
ASN X 161
TYR X 210
PRO X 311
DQP  X 402 ( 4.0A)
DQP  X 402 ( 4.1A)
NAP  X 401 (-3.2A)
NAP  X 401 ( 3.1A)
None
0.44A46.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R94_A_FLRA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens)		9 / 12LEU A  54
TYR A  55
HIS A 117
SER A 118
ASN A 167
TRP A 227
PHE A 306
PRO A 318
TYR A 319
None
CJ2  A 402 ( 4.1A)
CJ2  A 402 ( 3.8A)
CJ2  A 402 ( 3.7A)
NAP  A 401 ( 3.3A)
CJ2  A 402 ( 4.8A)
CJ2  A 402 (-3.8A)
None
None
1.07A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R94_A_FLRA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens)		9 / 12LEU A  54
TYR A  55
HIS A 117
SER A 118
ASN A 167
TYR A 216
TRP A 227
PRO A 318
TYR A 319
None
CJ2  A 402 ( 4.1A)
CJ2  A 402 ( 3.8A)
CJ2  A 402 ( 3.7A)
NAP  A 401 ( 3.3A)
NAP  A 401 ( 3.2A)
CJ2  A 402 ( 4.8A)
None
None
0.49A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R94_A_FLRA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens)		9 / 12LEU A  54
TYR A  55
HIS A 117
SER A 118
MET A 120
ASN A 167
TYR A 216
PRO A 318
TYR A 319
None
CJ2  A 402 ( 4.1A)
CJ2  A 402 ( 3.8A)
CJ2  A 402 ( 3.7A)
CJ2  A 402 ( 4.7A)
NAP  A 401 ( 3.3A)
NAP  A 401 ( 3.2A)
None
None
0.35A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		1au8 CATHEPSIN G
(Homo
sapiens)		5 / 12VAL A  52
LEU A  68
ALA A  85
SER A 109
LEU A 108
None
0.92A15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens)		5 / 12VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
None
0.89A22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		1lcy HTRA2 SERINE
PROTEASE
(Homo
sapiens)		5 / 12VAL A  54
LEU A 209
VAL A 187
GLY A 186
LEU A 112
None
0.94A20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		1xm9 PLAKOPHILIN 1
(Homo
sapiens)		5 / 12VAL A 619
LEU A 623
VAL A 591
GLY A 594
ALA A 595
None
1.04A21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2zec TRYPTASE BETA 2
(Homo
sapiens)		5 / 12VAL A  61
VAL A  54
VAL A 226
GLY A 211
LEU A  33
None
0.83A16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3dw8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
55 KDA REGULATORY
SUBUNIT B ALPHA
ISOFORM
(Homo
sapiens)		5 / 12VAL B  52
LEU B 111
VAL B 164
ALA B 166
SER B 167
None
1.00A20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3tfy N-ALPHA-ACETYLTRANSF
ERASE 50, NATE
CATALYTIC SUBUNIT
(Homo
sapiens)		5 / 12VAL A  11
TYR A  36
TYR A  50
GLY A  57
ALA A  58
None
0.97A15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3vzb SPHINGOSINE KINASE 1
(Homo
sapiens)		5 / 12VAL A  64
ARG A  94
LEU A  75
ALA A 100
LEU A  91
None
0.97A20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens)		5 / 12VAL A 642
VAL A 609
GLY A 611
ALA A 612
LEU A 616
None
1.04A21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		4yyp SCL-INTERRUPTING
LOCUS PROTEIN
SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens)		6 / 12VAL A 907
LEU A 955
VAL A 923
GLY A 922
ALA A 921
LEU B 736
None
1.49A10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5igq E3 UBIQUITIN-PROTEIN
LIGASE RFWD2
(Homo
sapiens)		5 / 12VAL A 447
LEU A 486
GLY A 440
ALA A 439
SER A 426
None
1.07A20.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens)		12 / 12VAL A 116
ARG A 120
VAL A 349
TYR A 355
LEU A 359
TYR A 385
TRP A 387
VAL A 523
GLY A 526
ALA A 527
SER A 530
LEU A 531
None
ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 (-3.8A)
None
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
0.36A88.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5jpn COMPLEMENT C4-A
(Homo
sapiens)		5 / 12VAL B1368
VAL B1380
TYR B 946
LEU B1378
GLY B 962
None
1.06A20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5wpb HISTONE DEACETYLASE
6
(Homo
sapiens)		5 / 12VAL A1190
VAL A1119
LEU A1172
ALA A1194
LEU A1195
None
1.05A9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5yje PROTEIN HIRA
(Homo
sapiens)		5 / 12LEU A 757
TRP A 730
VAL A 747
GLY A 743
LEU A 780
None
1.00A9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		1au8 CATHEPSIN G
(Homo
sapiens)		5 / 12VAL A  52
LEU A  68
ALA A  85
SER A 109
LEU A 108
None
0.92A15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens)		5 / 12VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
None
0.90A22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		1lcy HTRA2 SERINE
PROTEASE
(Homo
sapiens)		5 / 12VAL A  54
LEU A 209
VAL A 187
GLY A 186
LEU A 112
None
0.94A20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		1xm9 PLAKOPHILIN 1
(Homo
sapiens)		5 / 12VAL A 619
LEU A 623
VAL A 591
GLY A 594
ALA A 595
None
1.03A21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2zec TRYPTASE BETA 2
(Homo
sapiens)		5 / 12VAL A  61
VAL A  54
VAL A 226
GLY A 211
LEU A  33
None
0.83A16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3dw8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
55 KDA REGULATORY
SUBUNIT B ALPHA
ISOFORM
(Homo
sapiens)		5 / 12VAL B  52
LEU B 111
VAL B 164
ALA B 166
SER B 167
None
0.98A20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3tfy N-ALPHA-ACETYLTRANSF
ERASE 50, NATE
CATALYTIC SUBUNIT
(Homo
sapiens)		5 / 12VAL A  11
TYR A  36
TYR A  50
GLY A  57
ALA A  58
None
0.98A15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3vzb SPHINGOSINE KINASE 1
(Homo
sapiens)		5 / 12VAL A  64
ARG A  94
LEU A  75
ALA A 100
LEU A  91
None
0.97A20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens)		5 / 12VAL A 642
VAL A 609
GLY A 611
ALA A 612
LEU A 616
None
1.04A21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		4yyp SCL-INTERRUPTING
LOCUS PROTEIN
SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens)		6 / 12VAL A 907
LEU A 955
VAL A 923
GLY A 922
ALA A 921
LEU B 736
None
1.50A10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5igq E3 UBIQUITIN-PROTEIN
LIGASE RFWD2
(Homo
sapiens)		5 / 12VAL A 447
LEU A 486
GLY A 440
ALA A 439
SER A 426
None
1.06A20.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens)		12 / 12VAL A 116
ARG A 120
VAL A 349
TYR A 355
LEU A 359
TYR A 385
TRP A 387
VAL A 523
GLY A 526
ALA A 527
SER A 530
LEU A 531
None
ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 (-3.8A)
None
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
0.36A88.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5jpn COMPLEMENT C4-A
(Homo
sapiens)		5 / 12VAL B1368
VAL B1380
TYR B 946
LEU B1378
GLY B 962
None
1.05A20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5wpb HISTONE DEACETYLASE
6
(Homo
sapiens)		5 / 12VAL A1190
VAL A1119
LEU A1172
ALA A1194
LEU A1195
None
1.04A9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5yje PROTEIN HIRA
(Homo
sapiens)		5 / 12LEU A 757
TRP A 730
VAL A 747
GLY A 743
LEU A 780
None
1.00A9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		1nfi I-KAPPA-B-ALPHA
(Homo
sapiens)		5 / 12VAL E  97
LEU E 115
LEU E  78
GLY E 132
ALA E 133
None
1.05A16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		1xm9 PLAKOPHILIN 1
(Homo
sapiens)		5 / 12VAL A 619
LEU A 623
VAL A 591
GLY A 594
ALA A 595
None
1.04A21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens)		5 / 12VAL A 436
LEU A 517
LEU A 493
GLY A 478
ALA A 479
None
1.04A22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3dw8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
55 KDA REGULATORY
SUBUNIT B ALPHA
ISOFORM
(Homo
sapiens)		5 / 12VAL B  52
LEU B 111
VAL B 164
ALA B 166
SER B 167
None
0.99A20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3g04 THYROTROPIN RECEPTOR
(Homo
sapiens)		5 / 12VAL C 224
LEU C 184
LEU C 202
VAL C 192
ALA C 196
None
1.12A19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3tfy N-ALPHA-ACETYLTRANSF
ERASE 50, NATE
CATALYTIC SUBUNIT
(Homo
sapiens)		5 / 12VAL A  11
TYR A  36
TYR A  50
GLY A  57
ALA A  58
None
0.98A15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3ut3 PLASMINOGEN
ACTIVATOR INHIBITOR
1
(Homo
sapiens)		5 / 12VAL A 140
LEU A 286
LEU A 151
VAL A  42
GLY A  38
None
0.95A20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		4xzp GALECTIN-4
(Homo
sapiens)		5 / 12VAL A  33
VAL A 138
LEU A  17
LEU A 136
GLY A  37
None
1.00A15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5igq E3 UBIQUITIN-PROTEIN
LIGASE RFWD2
(Homo
sapiens)		5 / 12VAL A 447
LEU A 486
GLY A 440
ALA A 439
SER A 426
None
1.06A20.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens)		12 / 12VAL A 116
ARG A 120
VAL A 349
LEU A 352
TYR A 355
LEU A 359
TYR A 385
TRP A 387
VAL A 523
GLY A 526
ALA A 527
SER A 530
None
ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 (-3.8A)
None
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
0.41A88.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5jpn COMPLEMENT C4-A
(Homo
sapiens)		5 / 12VAL B1368
VAL B1380
LEU B 944
LEU B1378
GLY B 962
None
0.91A20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5jpn COMPLEMENT C4-A
(Homo
sapiens)		5 / 12VAL B1368
VAL B1380
TYR B 946
LEU B1378
GLY B 962
None
1.06A20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		1nfi I-KAPPA-B-ALPHA
(Homo
sapiens)		5 / 12VAL E  97
LEU E 115
LEU E  78
GLY E 132
ALA E 133
None
1.06A16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		1xm9 PLAKOPHILIN 1
(Homo
sapiens)		5 / 12VAL A 619
LEU A 623
VAL A 591
GLY A 594
ALA A 595
None
1.04A21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens)		5 / 12VAL A 436
LEU A 517
LEU A 493
GLY A 478
ALA A 479
None
1.03A22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3dw8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
55 KDA REGULATORY
SUBUNIT B ALPHA
ISOFORM
(Homo
sapiens)		5 / 12VAL B  52
LEU B 111
VAL B 164
ALA B 166
SER B 167
None
0.99A20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3g04 THYROTROPIN RECEPTOR
(Homo
sapiens)		5 / 12VAL C 224
LEU C 184
LEU C 202
VAL C 192
ALA C 196
None
1.12A19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3tfy N-ALPHA-ACETYLTRANSF
ERASE 50, NATE
CATALYTIC SUBUNIT
(Homo
sapiens)		5 / 12VAL A  11
TYR A  36
TYR A  50
GLY A  57
ALA A  58
None
0.98A15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3ut3 PLASMINOGEN
ACTIVATOR INHIBITOR
1
(Homo
sapiens)		5 / 12VAL A 140
LEU A 286
LEU A 151
VAL A  42
GLY A  38
None
0.95A20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		4xzp GALECTIN-4
(Homo
sapiens)		5 / 12VAL A  33
VAL A 138
LEU A  17
LEU A 136
GLY A  37
None
1.00A15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5igq E3 UBIQUITIN-PROTEIN
LIGASE RFWD2
(Homo
sapiens)		5 / 12VAL A 447
LEU A 486
GLY A 440
ALA A 439
SER A 426
None
1.06A20.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens)		12 / 12VAL A 116
ARG A 120
VAL A 349
LEU A 352
TYR A 355
LEU A 359
TYR A 385
TRP A 387
VAL A 523
GLY A 526
ALA A 527
SER A 530
None
ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 (-3.8A)
None
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
0.42A88.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5jpn COMPLEMENT C4-A
(Homo
sapiens)		5 / 12VAL B1368
VAL B1380
LEU B 944
LEU B1378
GLY B 962
None
0.90A20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5jpn COMPLEMENT C4-A
(Homo
sapiens)		5 / 12VAL B1368
VAL B1380
TYR B 946
LEU B1378
GLY B 962
None
1.06A20.47