POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		1ex0 COAGULATION FACTOR
XIII A CHAIN
(Homo
sapiens)		5 / 12THR A 688
GLN A 690
THR A 649
VAL A 648
VAL A 665
None
1.20A21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2
(Homo
sapiens)		5 / 12ILE A 369
VAL A 337
GLU A 168
VAL A 377
GLU A 376
None
1.15A15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		2ce9 TRANSDUCIN-LIKE
ENHANCER PROTEIN 1
(Homo
sapiens)		5 / 12THR A 480
THR A 501
VAL A 507
SER A 758
VAL A 742
None
1.13A15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		2d39 FICOLIN-1
(Homo
sapiens)		5 / 12VAL A 157
VAL A 144
GLU A 320
SER A 319
VAL A 318
None
1.40A11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT
AP-2 COMPLEX SUBUNIT
BETA
(Rattus
norvegicus;
Homo
sapiens)		5 / 12ILE B 548
GLN A 577
VAL B 541
GLU A 575
VAL A 535
None
1.30A19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		2z0v SH3-CONTAINING
GRB2-LIKE PROTEIN 3
(Homo
sapiens)		5 / 12ILE A 117
GLN A 114
THR A  50
VAL A  51
SER A 107
None
1.30A11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		3e0g LEUKEMIA INHIBITORY
FACTOR RECEPTOR
(Homo
sapiens)		5 / 12THR A 261
VAL A 275
VAL A 263
SER A 258
VAL A 311
None
1.40A16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Homo
sapiens;
Homo
sapiens)		5 / 12ILE B 320
VAL A 419
SER A 416
VAL A 437
GLU A 414
None
1.35A20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		3mfg V_SEGMENT
TRANSLATION PRODUCT
(Homo
sapiens)		5 / 12ILE B  67
THR B  76
THR B 111
SER B   5
VAL B   4
None
1.24A7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		3qfv CDC42BPB PROTEIN
(Homo
sapiens)		5 / 12ILE A 321
GLN A 318
GLU A 311
SER A 310
VAL A 309
None
1.39A16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		4f9o HEXOKINASE-1
(Homo
sapiens)		5 / 12THR A 821
VAL A 822
VAL A 825
SER A 816
GLU A 252
None
1.29A23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 A CHAIN
(Homo
sapiens)		5 / 12THR G 419
VAL G 411
LYS G 409
VAL G 364
GLU G 333
None
1.02A8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		4ozi T-CELL RECEPTOR, S2,
BETA CHAIN
(Homo
sapiens)		5 / 12ILE F  78
THR F  88
THR F 120
SER F   5
VAL F   4
None
1.20A12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		5cuz METHYLMALONIC
ACIDURIA AND
HOMOCYSTINURIA TYPE
D PROTEIN,
MITOCHONDRIAL
(Homo
sapiens)		5 / 12THR A 152
GLN A 151
THR A 177
VAL A 178
VAL A 276
None
1.26A10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens)		5 / 12THR A 359
GLN A 362
THR A 503
VAL A 514
VAL A 505
None
1.35A19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		5mpo MOLYBDOPTERIN
SYNTHASE SULFUR
CARRIER SUBUNIT
(Homo
sapiens)		5 / 12ILE A  82
THR A  19
GLU A  24
SER A  23
GLU A  78
None
1.36A6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		5v8l PGT145 ANTIBODY,
LIGHT CHAIN
(Homo
sapiens)		5 / 12ILE N   4
THR N   5
GLN N   6
THR N 102
VAL N 104
None
1.37A11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE SIGMA
FACTOR SIGA)		1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2
(Homo
sapiens)		4 / 4LEU A 351
ASP A 219
GLN A 193
VAL A 315
None
1.48A22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE SIGMA
FACTOR SIGA)		2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G
(Homo
sapiens)		4 / 4LEU A 273
ASP A 279
GLN A 126
VAL A  72
None
1.34A20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE SIGMA
FACTOR SIGA)		3lqz HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DP ALPHA 1
CHAIN
(Homo
sapiens)		4 / 4LEU A 170
ASP A 171
GLN A 172
VAL A 132
None
1.44A16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE SIGMA
FACTOR SIGA)		4a5w COMPLEMENT C5
(Homo
sapiens)		4 / 4LEU A 379
ASP A 377
GLN A 381
VAL A 612
None
1.49A16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2
(Homo
sapiens)		4 / 8ILE A  17
THR A  16
THR A 365
SER A 358
None
1.13Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)
(Homo
sapiens)		4 / 8ILE A 396
GLN A 366
THR A 100
SER A  91
None
0.96Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		2nmp CYSTATHIONINE
GAMMA-LYASE
(Homo
sapiens)		4 / 8ILE A 290
THR A 163
THR A 158
SER A 138
None
1.08Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		2v9t ROUNDABOUT HOMOLOG 1
SLIT HOMOLOG 2
PROTEIN N-PRODUCT
(Homo
sapiens;
Homo
sapiens)		4 / 8ILE A  70
ARG B 287
LYS B 289
SER B 280
None
0.99Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens)		4 / 8ILE A 130
THR A 132
LYS A  37
SER A 146
None
1.12Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		4wgk NEUTRAL CERAMIDASE
(Homo
sapiens)		4 / 8ILE A 255
THR A 543
GLU A 585
SER A 261
None
1.12Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		5o1p ALPHA-AMINOADIPIC
SEMIALDEHYDE
SYNTHASE,
MITOCHONDRIAL
(Homo
sapiens)		4 / 8THR A 855
LYS A 912
GLU A 614
SER A 615
None
1.12Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		1ibx DNA FRAGMENTATION
FACTOR 40
CHIMERA OF IGG
BINDING PROTEIN G
AND DNA
FRAGMENTATION FACTOR
45
(Homo
sapiens;
Streptococcus
sp.;
Homo
sapiens)		3 / 3ARG A  31
LYS A  32
ARG B  43
None
1.27Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		1jmo HEPARIN COFACTOR II
(Homo
sapiens)		3 / 3ARG A 120
LYS A 123
ARG A 479
None
1.34Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		2id5 LEUCINE RICH REPEAT
NEURONAL 6A
(Homo
sapiens)		3 / 3ARG A 201
LYS A 203
ARG A 245
None
NAG  A 488 (-3.9A)
None
1.32Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		2l7b APOLIPOPROTEIN E
(Homo
sapiens)		3 / 3ARG A 142
LYS A 146
ARG A 274
None
1.06Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		3eab SPASTIN
CHMP1B
(Homo
sapiens;
Homo
sapiens)		3 / 3ARG A 176
LYS A 180
ARG G 196
None
1.32Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		3kuf FRAGILE X MENTAL
RETARDATION
SYNDROME-RELATED
PROTEIN 1
(Homo
sapiens)		3 / 3ARG A  84
LYS A  82
ARG A  47
None
GOL  A 134 (-3.0A)
None
1.35Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens)		3 / 3ARG A1787
LYS A1789
ARG A1919
None
0.85Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		4cem REGULATOR OF
NONSENSE TRANSCRIPTS
2
(Homo
sapiens)		3 / 3ARG A 325
LYS A 328
ARG A 141
None
1.30Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		4d86 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens)		3 / 3ARG A1113
LYS A1154
ARG A 898
None
1.14Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		4h10 ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR-LIKE
PROTEIN 1
CIRCADIAN LOCOMOTER
OUTPUT CYCLES
PROTEIN KAPUT
(Homo
sapiens;
Homo
sapiens)		3 / 3ARG A  83
LYS A  87
ARG B  82
None
1.28Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		4k3j HEPATOCYTE GROWTH
FACTOR
HEPATOCYTE GROWTH
FACTOR BETA CHAIN
(Homo
sapiens;
Homo
sapiens)		3 / 3ARG A 630
LYS A 495
ARG B 143
None
1.33Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		4k5y CORTICOTROPIN-RELEAS
ING FACTOR RECEPTOR
1, T4-LYSOZYME
CHIMERIC CONSTRUCT
(Homo
sapiens;
Escherichia
virus
T4)		3 / 3ARG A1008
LYS A1060
ARG A 292
None
0.90Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		3 / 3ARG K 250
LYS K 260
ARG K 192
None
1.08Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens)		3 / 3ARG A1129
LYS A1139
ARG A1453
None
0.99Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		5ii0 CALCITONIN RECEPTOR
(Homo
sapiens)		3 / 3ARG A  58
LYS A  54
ARG A  45
None
1.36Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		5t1a CHIMERA PROTEIN OF
CC CHEMOKINE
RECEPTOR TYPE 2
ISOFORM B AND
T4-LYSOZYME,LYSOZYME
(Homo
sapiens;
Escherichia
virus
T4)		3 / 3ARG A 232
LYS A 239
ARG A 313
OLC  A1207 (-3.5A)
OLC  A1207 (-3.7A)
None
1.31Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		1pk6 COMPLEMENT C1Q
SUBCOMPONENT, A
CHAIN PRECURSOR
COMPLEMENT C1Q
SUBCOMPONENT, C
CHAIN PRECURSOR
(Homo
sapiens;
Homo
sapiens)		4 / 8GLN A 177
THR A 171
LYS C 170
GLU A 148
 CA  B   1 (-3.2A)
None
None
None
0.98A7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		1u3t ALCOHOL
DEHYDROGENASE ALPHA
CHAIN
(Homo
sapiens)		4 / 8ILE A 143
THR A  59
VAL A  58
SER A 117
None
1.10A15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		2xd7 CORE HISTONE
MACRO-H2A.2
(Homo
sapiens)		4 / 8ILE A 274
THR A 330
VAL A 329
GLU A 291
None
1.00A9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		2z0v SH3-CONTAINING
GRB2-LIKE PROTEIN 3
(Homo
sapiens)		4 / 8ILE A 117
GLN A 114
THR A  50
VAL A  51
None
1.16A11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		4duu PLASMINOGEN
(Homo
sapiens)		4 / 8ILE A 754
THR A 591
VAL A 577
SER A 594
None
1.13A20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens)		4 / 8ILE A1464
THR A1507
VAL A1506
GLU A1455
None
0.95A21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens)		4 / 8ILE A 635
THR A 811
VAL A 810
GLU A 807
None
0.99A20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		5xtb NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
6, MITOCHONDRIAL
(Homo
sapiens)		4 / 8GLN T 118
THR T 109
GLU T  79
SER T  78
None
1.06A7.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		6d6u GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
(Homo
sapiens)		4 / 8MET B 236
ILE B 235
THR B 265
SER B 270
None
0.77A15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		1by4 PROTEIN (RETINOIC
ACID RECEPTOR
RXR-ALPHA)
(Homo
sapiens)		4 / 8LYS A1181
ARG A1184
VAL A1149
ARG A1161
None
ZN  A1330 ( 4.6A)
None
None
1.23A4.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens)		4 / 8ASP A 419
ARG A 395
LYS A 422
VAL A 451
NAG  A 921 ( 3.9A)
None
None
None
1.04A16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		3g4e REGUCALCIN
(Homo
sapiens)		4 / 8LYS A 198
GLU A 200
VAL A 216
GLN A 275
None
1.18A13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3
(Homo
sapiens)		4 / 8ASP A 276
ARG A  39
GLU A 362
VAL A 368
Z99  A 485 ( 3.8A)
Z99  A 485 (-3.8A)
None
None
1.27A16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		3t1i DOUBLE-STRAND BREAK
REPAIR PROTEIN
MRE11A
(Homo
sapiens)		4 / 8ASP A 136
ARG A 155
VAL A 150
GLN A 218
None
1.08A16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		4cca SYNTAXIN-BINDING
PROTEIN 2
(Homo
sapiens)		4 / 8GLU A 562
VAL A   9
ARG A 292
GLN A 250
None
1.12A18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE
(Homo
sapiens)		4 / 8ARG B1648
VAL B1617
ARG B 603
GLN B 607
None
1.23A22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens)		4 / 8ASP A  79
ARG A  90
GLU A  98
ARG A 132
None
1.26A12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1
(Homo
sapiens)		4 / 8ARG A 597
ARG A 563
VAL A 518
GLN A  62
None
1.14A22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		4rz9 PRE-MRNA-SPLICING
FACTOR 38A
(Homo
sapiens)		4 / 8ASP A 126
ARG A 128
LYS A  97
VAL A 157
None
1.22A9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		5foe GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2,THROMBOSPONDIN-1
(Caenorhabditis
elegans;
Homo
sapiens)		4 / 8ARG A 216
ARG A  57
VAL A  96
GLN A 367
None
1.16A17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		5jho ELECTRONEUTRAL
SODIUM BICARBONATE
EXCHANGER 1
(Homo
sapiens)		4 / 8ASP A  92
ARG A 305
GLU A  66
VAL A 280
None
1.17A15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		5mc5 XAA-PRO DIPEPTIDASE
(Homo
sapiens)		4 / 8ARG A 450
GLU A 412
VAL A 376
ARG A 469
PRO  A 504 (-3.7A)
MN  A 499 (-2.8A)
None
None
1.03Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		5okl AFAMIN
(Homo
sapiens)		4 / 8ASP A 455
ARG A 486
GLU A 460
ARG A 524
None
1.26Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		5u1d ANTIGEN PEPTIDE
TRANSPORTER 1
ANTIGEN PEPTIDE
TRANSPORTER 2
TAP TRANSPORTER
INHIBITOR ICP47
(Homo
sapiens;
Homo
sapiens;
Human
alphaherpesvirus
1)		4 / 8ASP A 297
GLU X  28
VAL A 460
GLN B 424
None
1.21A21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
(Homo
sapiens)		4 / 8ARG C 172
ARG C  36
GLU C 145
GLN C  44
None
1.24Aundetectable