POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		1sgo PROTEIN C14ORF129
(Homo
sapiens)		4 / 5GLY A 137
ASP A 136
ARG A 135
GLN A 128
None
1.46A9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		2nym SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens)		4 / 5GLY C  56
ASP C  57
ARG C 239
GLN C 288
None
MN  C 502 ( 3.2A)
None
None
1.39A16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		2p0r CALPAIN-9
(Homo
sapiens)		4 / 5GLY A 315
ASP A 314
ARG A 275
MET A 196
None
CA  A1002 (-3.0A)
None
None
1.35A17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		3l82 F-BOX ONLY PROTEIN 4
(Homo
sapiens)		4 / 5GLY B 288
ASP B 287
ARG B 178
MET B 198
None
1.32A14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		4a3p UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15
(Homo
sapiens)		4 / 5GLY A  27
ASP A  28
ARG A  25
GLN A 120
None
1.26A13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens)		4 / 5GLY A 570
ARG A 534
GLN A 551
MET A 502
None
1.35A19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		4z2a FURIN
(Homo
sapiens)		4 / 5GLY A 195
ASP A 154
ARG A 193
GLN A 358
None
None
PO4  A 606 ( 2.5A)
None
1.14A19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		4z2a FURIN
(Homo
sapiens)		4 / 5GLY A 195
ASP A 154
ARG A 197
GLN A 358
None
None
PO4  A 606 ( 2.9A)
None
1.36A19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		5elt KH
DOMAIN-CONTAINING,
RNA-BINDING, SIGNAL
TRANSDUCTION-ASSOCIA
TED PROTEIN 3
(Homo
sapiens)		4 / 5GLY B  99
ASP B 125
GLN B  58
MET B 144
None
1.18A13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		5nge UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens)		4 / 5GLY A 326
ASP A 346
GLN A 297
MET A 407
None
None
8WK  A 601 (-3.2A)
8WK  A 601 (-3.9A)
1.41A17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		5udh E3 UBIQUITIN-PROTEIN
LIGASE ARIH1
(Homo
sapiens)		4 / 5GLY A 355
ASP A 354
ARG A 511
GLN A 440
None
1.35A18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		6bdt CALPAIN-3
(Homo
sapiens)		4 / 5GLY A 395
ASP A 394
ARG A 355
MET A 228
None
CA  A 502 (-3.3A)
None
None
1.34A6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		6eoq DIPEPTIDYL PEPTIDASE
9
(Homo
sapiens)		4 / 5GLY A 501
ASP A 425
ARG A 499
GLN A 247
None
1.29A8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		2hi4 CYTOCHROME P450 1A2
(Homo
sapiens)		4 / 5GLY A 285
ASP A 282
ARG A 281
GLN A 273
None
1.29A19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		2nq3 ITCHY HOMOLOG E3
UBIQUITIN PROTEIN
LIGASE
(Homo
sapiens)		4 / 5GLY A  96
ASP A 125
ARG A  82
GLN A  87
None
1.38A12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		2nym SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens)		4 / 5GLY C  56
ASP C  57
ARG C 239
GLN C 288
None
MN  C 502 ( 3.2A)
None
None
1.45A16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		2p0r CALPAIN-9
(Homo
sapiens)		4 / 5GLY A 315
ASP A 314
ARG A 275
MET A 196
None
CA  A1002 (-3.0A)
None
None
1.43A17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens)		4 / 5GLY A1334
ASP A1337
ARG A1333
MET A1417
None
0.98A22.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		4a3p UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15
(Homo
sapiens)		4 / 5GLY A  27
ASP A  28
ARG A  25
GLN A 120
None
1.20A13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens)		4 / 5GLY A 570
ARG A 534
GLN A 551
MET A 502
None
1.48A19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens)		4 / 5GLY A 241
ASP A 245
ARG A 172
GLN A 165
None
1.34A17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		5elt KH
DOMAIN-CONTAINING,
RNA-BINDING, SIGNAL
TRANSDUCTION-ASSOCIA
TED PROTEIN 3
(Homo
sapiens)		4 / 5GLY B  99
ASP B 125
GLN B  58
MET B 144
None
1.12A13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		5nzp D-3-PHOSPHOGLYCERATE
DEHYDROGENASE
(Homo
sapiens)		4 / 5GLY B 152
ASP B 175
ARG B 158
GLN B 189
9EW  B 301 ( 4.6A)
9EW  B 301 ( 4.6A)
None
None
1.44A13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		6ez8 HUNTINGTIN
(Homo
sapiens)		4 / 5GLY A2964
ARG A2962
GLN A3006
MET A3076
None
1.20A5.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		1k86 CASPASE-7
(Homo
sapiens)		5 / 6SER A 275
GLU A 274
GLY A  89
ASP A  93
GLY A 236
None
1.44A19.04
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		1n0w DNA REPAIR PROTEIN
RAD51 HOMOLOG 1
(Homo
sapiens)		4 / 6GLU A 154
GLY A 333
ASP A 332
GLY A 105
EDO  A 502 (-2.9A)
None
None
None
0.88A19.63
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		2gf1 INSULIN-LIKE GROWTH
FACTOR I
(Homo
sapiens)		4 / 6GLU A   9
GLY A  22
ARG A  21
GLY A  19
None
0.74A9.44
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		2jbh PHOSPHORIBOSYLTRANSF
ERASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		4 / 6SER A 155
GLY A 180
ASP A 179
GLY A 147
None
None
None
5GP  A1230 (-3.5A)
0.86A19.27
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		2vre DELTA(3,5)-DELTA(2,4
)-DIENOYL-COA
ISOMERASE
(Homo
sapiens)		5 / 6SER A  31
GLU A  30
GLY A 149
ASP A 151
GLY A  91
None
1.13A21.95
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens)		4 / 6SER A 821
GLU A 820
GLY A 877
GLY A 840
None
0.63A19.04
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		4u7l LEUCINE-RICH REPEATS
AND
IMMUNOGLOBULIN-LIKE
DOMAINS PROTEIN 1
(Homo
sapiens)		4 / 6GLU A 271
GLY A 340
ASP A 342
GLY A 313
None
0.81A22.00
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		1n0w DNA REPAIR PROTEIN
RAD51 HOMOLOG 1
(Homo
sapiens)		4 / 6GLU A 154
GLY A 333
ASP A 332
GLY A 105
EDO  A 502 (-2.9A)
None
None
None
0.85A19.63
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		1wju NEDD8 ULTIMATE
BUSTER-1
(Homo
sapiens)		4 / 6GLU A  90
GLY A  72
ARG A  43
GLY A  42
None
0.83A13.12
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		2es3 THROMBOSPONDIN-1
(Homo
sapiens)		4 / 6GLY A  84
ASP A 188
ARG A  83
GLY A 105
None
0.89A19.38
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		2jbh PHOSPHORIBOSYLTRANSF
ERASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		4 / 6SER A 155
GLY A 180
ASP A 179
GLY A 147
None
None
None
5GP  A1230 (-3.5A)
0.91A19.27
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens)		4 / 6SER A 821
GLU A 820
GLY A 877
GLY A 840
None
0.67A19.04
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens)		4 / 6SER A 285
GLU A 286
GLY A 222
GLY A 218
None
0.91A20.52
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		4u7l LEUCINE-RICH REPEATS
AND
IMMUNOGLOBULIN-LIKE
DOMAINS PROTEIN 1
(Homo
sapiens)		4 / 6GLU A 271
GLY A 340
ASP A 342
GLY A 313
None
0.84A22.00
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens)		4 / 6GLU A 455
GLY A 509
ASP A 442
GLY A 507
None
0.90A16.67
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens)		4 / 6GLY A 478
ASP A 479
ARG A 503
GLY A 504
N2W  A1302 ( 3.0A)
N2W  A1302 ( 3.4A)
N2S  A1301 ( 3.9A)
N2W  A1302 ( 4.4A)
0.67A21.66
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		5gwn PROTEIN RCC2
(Homo
sapiens)		4 / 6GLU A 264
GLY A 185
ASP A 186
GLY A 183
None
None
SO4  A 603 (-4.4A)
None
0.87A22.07
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		5iaa UBIQUITIN-FOLD
MODIFIER 1
UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 5
(Homo
sapiens)		4 / 6GLU A 132
GLY C  83
ASP A 183
GLY A  83
None
0.88A21.38
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6c01 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 3
(Homo
sapiens)		4 / 6GLU A 516
GLY A 168
ASP A 167
GLY A 374
None
None
ZN  A 902 (-2.0A)
None
0.89A10.82
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		1n0w DNA REPAIR PROTEIN
RAD51 HOMOLOG 1
(Homo
sapiens)		4 / 6GLU A 154
GLY A 333
ASP A 332
GLY A 105
EDO  A 502 (-2.9A)
None
None
None
0.84A19.63
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		1uou THYMIDINE
PHOSPHORYLASE
(Homo
sapiens)		4 / 6SER A 169
GLU A 171
GLY A 163
GLY A 351
None
0.94A21.88
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		2ax4 BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 2
(Homo
sapiens)		4 / 6GLU A 147
GLY A  41
ARG A  51
GLY A 124
None
0.59A15.18
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		2ffu POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens)		4 / 6SER A 489
GLU A 487
GLY A 469
ASP A 458
None
0.93A22.24
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		2gf1 INSULIN-LIKE GROWTH
FACTOR I
(Homo
sapiens)		4 / 6GLU A   9
GLY A  22
ARG A  21
GLY A  19
None
0.61A9.44
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		2zgh GRANZYME M
(Homo
sapiens)		4 / 6SER A  61
GLY A 126
ARG A 139
GLY A 124
None
None
SO4  A 241 (-3.9A)
None
0.92A17.49
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		3fg6 ADSEVERIN
(Homo
sapiens)		4 / 6SER A 537
GLU A 606
ASP A 529
GLY A 709
None
0.90A21.98
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		4ag4 EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1
(Homo
sapiens)		4 / 6SER A 259
ASP A 240
ARG A 242
GLY A 252
None
0.94A21.07
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		4cak INTEGRIN ALPHA-IIB
(Homo
sapiens)		4 / 6SER A 733
GLY A 370
ASP A 369
GLY A 300
None
0.93A19.29
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1
(Homo
sapiens)		4 / 6GLU A 288
ASP A 240
ARG A 219
GLY A 218
None
0.68A20.50
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens)		4 / 6SER A 412
GLY A 254
ASP A 255
GLY A 419
None
0.82A21.83
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		5gwn PROTEIN RCC2
(Homo
sapiens)		4 / 6GLU A 264
GLY A 185
ASP A 186
GLY A 183
None
None
SO4  A 603 (-4.4A)
None
0.82A22.07
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		5iaa UBIQUITIN-FOLD
MODIFIER 1
UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 5
(Homo
sapiens)		4 / 6GLU A 132
GLY C  83
ASP A 183
GLY A  83
None
0.86A21.38
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3
(Homo
sapiens)		4 / 6GLU A 214
ASP A 166
ARG A 145
GLY A 144
None
0.80A19.46
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		5o2q BREAST CANCER
ANTI-ESTROGEN
RESISTANCE
1,VINCULIN
(Homo
sapiens)		4 / 6SER A  49
GLY A  44
ASP A  38
GLY A  59
None
0.93A12.86
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		5ze3 LYSYL OXIDASE
HOMOLOG 2
(Homo
sapiens)		4 / 6SER A 609
GLY A 421
ARG A 423
GLY A 337
None
0.92A12.21
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6c01 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 3
(Homo
sapiens)		4 / 6GLU A 516
GLY A 168
ASP A 167
GLY A 374
None
None
ZN  A 902 (-2.0A)
None
0.89A10.82
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		1n0w DNA REPAIR PROTEIN
RAD51 HOMOLOG 1
(Homo
sapiens)		4 / 6GLU A 154
GLY A 333
ASP A 332
GLY A 105
EDO  A 502 (-2.9A)
None
None
None
0.84A19.63
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		1uou THYMIDINE
PHOSPHORYLASE
(Homo
sapiens)		4 / 6SER A 169
GLU A 171
GLY A 163
GLY A 351
None
0.92A21.88
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		2ax4 BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 2
(Homo
sapiens)		4 / 6GLU A 147
GLY A  41
ARG A  51
GLY A 124
None
0.60A15.18
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		2gf1 INSULIN-LIKE GROWTH
FACTOR I
(Homo
sapiens)		4 / 6GLU A   9
GLY A  22
ARG A  21
GLY A  19
None
0.61A9.44
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		2zgh GRANZYME M
(Homo
sapiens)		4 / 6SER A  61
GLY A 126
ARG A 139
GLY A 124
None
None
SO4  A 241 (-3.9A)
None
0.94A17.49
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		3fg6 ADSEVERIN
(Homo
sapiens)		4 / 6SER A 537
GLU A 606
ASP A 529
GLY A 709
None
0.89A21.98
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		3h32 FIBRINOGEN BETA
CHAIN
(Homo
sapiens)		4 / 6SER B 451
GLU B 313
GLY B 272
GLY B 274
None
0.95A21.07
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		4cak INTEGRIN ALPHA-IIB
(Homo
sapiens)		4 / 6SER A 733
GLY A 370
ASP A 369
GLY A 300
None
0.94A19.29
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1
(Homo
sapiens)		4 / 6GLU A 288
ASP A 240
ARG A 219
GLY A 218
None
0.72A20.50
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		5gwn PROTEIN RCC2
(Homo
sapiens)		4 / 6GLU A 264
GLY A 185
ASP A 186
GLY A 183
None
None
SO4  A 603 (-4.4A)
None
0.85A22.07
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		5iaa UBIQUITIN-FOLD
MODIFIER 1
UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 5
(Homo
sapiens)		4 / 6GLU A 132
GLY C  83
ASP A 183
GLY A  83
None
0.87A21.38
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3
(Homo
sapiens)		4 / 6GLU A 214
ASP A 166
ARG A 145
GLY A 144
None
0.83A19.46
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		5o2q BREAST CANCER
ANTI-ESTROGEN
RESISTANCE
1,VINCULIN
(Homo
sapiens)		4 / 6SER A  49
GLY A  44
ASP A  38
GLY A  59
None
0.93A12.86
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		5ums FACT COMPLEX SUBUNIT
SSRP1
(Homo
sapiens)		4 / 6GLU A 392
ASP A 372
ARG A 370
GLY A 358
None
0.94A9.78
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		5ze3 LYSYL OXIDASE
HOMOLOG 2
(Homo
sapiens)		4 / 6SER A 609
GLY A 421
ARG A 423
GLY A 337
None
0.95A12.21
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		6c01 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 3
(Homo
sapiens)		4 / 6GLU A 516
GLY A 168
ASP A 167
GLY A 374
None
None
ZN  A 902 (-2.0A)
None
0.89A10.82
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		1k4q GLUTATHIONE
REDUCTASE
(Homo
sapiens)		4 / 6SER A  51
GLY A 330
ASP A 331
GLY A  31
FAD  A 499 (-3.1A)
FAD  A 499 (-3.3A)
FAD  A 499 (-2.9A)
FAD  A 499 (-3.7A)
0.86A22.16
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		2ac5 MAP
KINASE-INTERACTING
SERINE/THREONINE
KINASE 2
(Homo
sapiens)		4 / 6GLY A  91
ASP A  88
ARG A  97
GLY A  93
None
0.94A21.06
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		3c49 POLY(ADP-RIBOSE)
POLYMERASE 3
(Homo
sapiens)		4 / 6GLU A 367
GLY A 447
ASP A 467
GLY A 377
None
0.72A19.80
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		3hf8 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens)		4 / 6SER A 285
GLU A 380
GLY A 276
GLY A 331
None
0.85A21.54
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		4zg7 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2
(Homo
sapiens)		4 / 6GLU A 860
GLY A 315
ASP A 312
GLY A 473
None
None
ZN  A 903 ( 2.0A)
None
0.75A21.14
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		5l01 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens)		4 / 6SER A 285
GLU A 380
GLY A 276
GLY A 331
None
0.83A20.67
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_D_EVPD102_1
(DNA TOPOISOMERASE
2-ALPHA)		2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens)		4 / 4GLY A 202
ASP A 223
ARG A 200
MET A 239
None
1.24A17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_D_EVPD102_1
(DNA TOPOISOMERASE
2-ALPHA)		3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM
(Homo
sapiens)		4 / 4GLY A 130
ASP A 180
ARG A 649
MET A  99
None
1.43A20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_D_EVPD102_1
(DNA TOPOISOMERASE
2-ALPHA)		5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens)		4 / 4GLY C3618
ASP C3641
ARG C3629
MET C3796
None
1.38A11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_F_EVPF102_1
(DNA TOPOISOMERASE
2-ALPHA)		1ck7 PROTEIN (GELATINASE
A)
(Homo
sapiens)		4 / 5GLY A 255
ASP A 254
ARG A 252
MET A 282
None
1.47A21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_F_EVPF102_1
(DNA TOPOISOMERASE
2-ALPHA)		1ohe CDC14B2 PHOSPHATASE
(Homo
sapiens)		4 / 5GLY A 371
ASP A 372
ARG A 334
MET A 362
None
1.30A16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_F_EVPF102_1
(DNA TOPOISOMERASE
2-ALPHA)		2obh CENTRIN-2
(Homo
sapiens)		4 / 5GLY A  46
ASP A  41
MET A  93
MET A  97
None
1.32A11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_F_EVPF102_1
(DNA TOPOISOMERASE
2-ALPHA)		3snh DYNAMIN-1
(Homo
sapiens)		4 / 5GLY A 743
ASP A 744
ARG A 297
MET A 731
None
1.22A22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_F_EVPF102_1
(DNA TOPOISOMERASE
2-ALPHA)		5knn ALANINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens)		4 / 5GLY A 321
ASP A 316
ARG A 325
MET A 370
None
1.06A20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		1au8 CATHEPSIN G
(Homo
sapiens)		4 / 5GLY A 140
ASP A 194
ARG A 156
GLN A  74
None
1.36A13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		2p0r CALPAIN-9
(Homo
sapiens)		4 / 5GLY A 315
ASP A 314
ARG A 275
MET A 196
None
CA  A1002 (-3.0A)
None
None
1.34A17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		2pla GLYCEROL-3-PHOSPHATE
DEHYDROGENASE 1-LIKE
PROTEIN
(Homo
sapiens)		4 / 5GLY A 214
ASP A 217
ARG A 281
GLN A 338
None
1.30A18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		2wfx HEDGEHOG-INTERACTING
PROTEIN
(Homo
sapiens)		4 / 5GLY B 390
ASP B 371
ARG B 464
GLN B 356
None
1.27A19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		3auv SC-DSFV DERIVED FROM
THE G6-FAB
(Homo
sapiens)		4 / 5GLY A  79
ASP A  39
ARG A  35
GLN A 100
None
1.43A16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		3bg9 PYRUVATE
CARBOXYLASE,
MITOCHONDRIAL
(Homo
sapiens)		4 / 5GLY A 689
ARG A 644
GLN A 640
MET A 566
None
1.32A22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		3l2o F-BOX ONLY PROTEIN 4
(Homo
sapiens)		4 / 5GLY B 288
ASP B 287
ARG B 178
MET B 198
None
1.29A16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		3l82 F-BOX ONLY PROTEIN 4
(Homo
sapiens)		4 / 5GLY B 288
ASP B 287
ARG B 178
MET B 198
None
1.33A14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		3tdu DCN1-LIKE PROTEIN 1
(Homo
sapiens)		4 / 5GLY A  85
ASP A  84
GLN A 114
MET A 177
None
1.43A14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		4db1 MYOSIN-7
(Homo
sapiens)		4 / 5GLY A   2
ASP A   3
ARG A  17
GLN A  27
None
1.40A23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		4m7f FIBRINOGEN C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		4 / 5GLY A 280
ASP A 274
ARG A 276
GLN A 252
None
1.18A14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		4obs ALPHA-L-IDURONIDASE
(Homo
sapiens)		4 / 5GLY A 485
ASP A 484
ARG A 492
GLN A 500
None
1.28A21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		5vfr PROTEASOME SUBUNIT
ALPHA TYPE-4
(Homo
sapiens)		4 / 5GLY I  42
ASP I  41
ARG I 218
GLN I 146
None
1.16Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1
(Homo
sapiens)		4 / 5GLY A 592
ARG A 587
GLN A1380
MET A1383
None
1.05A16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)
(Homo
sapiens)		4 / 5GLY A 190
ASP A 187
GLN A 945
MET A 948
None
None
ZQU  A1305 (-3.8A)
ZQU  A1305 (-3.4A)
1.30A8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_F_EVPF1301_1
()		2p0r CALPAIN-9
(Homo
sapiens)		4 / 4GLY A 315
ASP A 314
ARG A 275
MET A 196
None
CA  A1002 (-3.0A)
None
None
1.28A17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_F_EVPF1301_1
()		3l2o F-BOX ONLY PROTEIN 4
(Homo
sapiens)		4 / 4GLY B 288
ASP B 287
ARG B 178
MET B 198
None
1.26A16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_F_EVPF1301_1
()		3l82 F-BOX ONLY PROTEIN 4
(Homo
sapiens)		4 / 4GLY B 288
ASP B 287
ARG B 178
MET B 198
None
1.28A14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_F_EVPF1301_1
()		6bdt CALPAIN-3
(Homo
sapiens)		4 / 4GLY A 395
ASP A 394
ARG A 355
MET A 228
None
CA  A 502 (-3.3A)
None
None
1.29A6.94