POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2
(Homo
sapiens)		11 / 12LYS A 101
LEU A 119
LEU A 122
ILE A 145
MET A 147
ASP A 194
LYS A 196
ASN A 199
ASP A 212
GLY A 214
VAL A 215
ATP  A 535 ( 2.5A)
5EA  A1001 (-4.9A)
5EA  A1001 (-4.9A)
5EA  A1001 ( 3.7A)
ATP  A 535 ( 3.4A)
ATP  A 535 ( 3.4A)
ATP  A 535 (-2.7A)
MG  A 536 (-2.8A)
MG  A 536 (-3.3A)
5EA  A1001 (-3.6A)
5EA  A1001 (-3.9A)
0.47A74.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens)		6 / 12LYS A 295
LEU A 325
ILE A 336
ASP A 386
ASN A 391
GLY A 406
H8H  A 534 (-3.7A)
None
H8H  A 534 ( 4.5A)
None
H8H  A 534 ( 4.9A)
None
1.04A19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens)		7 / 12LYS A 295
LEU A 325
ILE A 336
ASP A 386
ASN A 391
ASP A 404
GLY A 406
None
1.02A22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		2qlu ACTIVIN RECEPTOR
TYPE IIB
(Homo
sapiens)		5 / 12LYS A 217
ASP A 321
LYS A 323
ASN A 326
ASP A 339
None
None
SO4  A   2 (-3.0A)
None
None
0.76A28.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		2w9f CELL DIVISION
PROTEIN KINASE 4
(Homo
sapiens)		6 / 12LYS B  35
ASP B 140
LYS B 142
ASN B 145
ASP B 158
GLY B 160
None
1.17A29.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		2w9f CELL DIVISION
PROTEIN KINASE 4
(Homo
sapiens)		6 / 12LYS B  35
LEU B  60
ASP B 140
LYS B 142
ASN B 145
ASP B 158
None
1.29A29.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens)		5 / 12LEU A  81
ASP A 153
LYS A 155
ASN A 158
ASP A 171
None
None
None
None
B49  A1294 (-4.2A)
0.67A25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		3coi MITOGEN-ACTIVATED
PROTEIN KINASE 13
(Homo
sapiens)		5 / 12ASP A 150
LYS A 152
ASN A 155
ASP A 168
GLY A 170
None
0.73A27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens)		6 / 12MET A 220
ASP A 268
LYS A 270
ASN A 273
GLY A 296
GLY A 311
VIN  A6331 (-3.7A)
SO4  A8001 ( 4.8A)
SO4  A8001 (-3.0A)
VIN  A6331 ( 4.8A)
None
None
0.97A28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		3eo3 BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens)		6 / 12LEU A 504
ILE A 449
ASP A 515
GLY A 471
VAL A 470
GLY A 518
None
1.24A21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens)		6 / 12LEU A  84
ASP A 158
LYS A 160
ASN A 163
ASP A 179
GLY A 197
QUE  A   1 ( 4.6A)
None
None
None
QUE  A   1 (-2.9A)
None
1.09A26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens)		6 / 12LEU A 108
LEU A  84
ASP A 158
LYS A 160
ASN A 163
ASP A 179
None
QUE  A   1 ( 4.6A)
None
None
None
QUE  A   1 (-2.9A)
1.47A26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens)		6 / 12LEU A 108
LEU A  84
LYS A 160
ASN A 163
ASP A 179
GLY A 181
None
QUE  A   1 ( 4.6A)
None
None
QUE  A   1 (-2.9A)
None
1.42A26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens)		6 / 12LEU A 108
LEU A 110
ASP A 158
LYS A 160
ASN A 163
ASP A 179
None
QUE  A   1 (-4.1A)
None
None
None
QUE  A   1 (-2.9A)
1.45A26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		3rc0 N-LYSINE
METHYLTRANSFERASE
SETD6
(Homo
sapiens)		6 / 12LEU A 468
LEU A 465
ILE A 356
ASP A 312
VAL A 420
GLY A 349
None
1.33A22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		3rw9 SPERMIDINE SYNTHASE
(Homo
sapiens)		6 / 12LEU A 151
ILE A 130
ASP A 126
GLY A 154
VAL A 153
GLY A 179
None
1.45A23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3
(Homo
sapiens)		5 / 12LYS A  73
ILE A 116
MET A 118
ASP A 166
ASN A 171
I85  A 350 (-2.8A)
None
I85  A 350 ( 3.9A)
None
I85  A 350 (-4.4A)
0.75A25.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		3vn9 DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6
(Homo
sapiens)		7 / 12LYS A  82
ILE A 127
MET A 129
ASP A 179
LYS A 181
ASN A 184
ASP A 197
ANK  A 401 (-2.4A)
None
ANK  A 401 (-3.7A)
ANK  A 401 (-3.7A)
ANK  A 401 (-2.5A)
ANK  A 401 ( 2.7A)
MG  A 402 ( 2.8A)
0.75A39.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		3vn9 DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6
(Homo
sapiens)		7 / 12LYS A  82
MET A 129
ASP A 179
LYS A 181
ASN A 184
ASP A 197
GLY A 199
ANK  A 401 (-2.4A)
ANK  A 401 (-3.7A)
ANK  A 401 (-3.7A)
ANK  A 401 (-2.5A)
ANK  A 401 ( 2.7A)
MG  A 402 ( 2.8A)
None
0.80A39.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens)		8 / 12LYS A  98
LEU A 116
ILE A 142
ASP A 191
LYS A 193
ASN A 196
ASP A 209
GLY A 211
ANP  A 401 (-2.7A)
None
CHU  A 403 (-3.8A)
CHU  A 403 (-3.6A)
ANP  A 401 (-3.0A)
MG  A 402 ( 2.9A)
MG  A 402 (-3.2A)
CHU  A 403 ( 3.3A)
1.50A94.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens)		11 / 12LYS A  98
LEU A 116
LEU A 119
ILE A 142
MET A 144
ASP A 191
LYS A 193
ASN A 196
ASP A 209
GLY A 211
VAL A 212
ANP  A 401 (-2.7A)
None
CHU  A 403 (-4.4A)
CHU  A 403 (-3.8A)
CHU  A 403 (-3.8A)
CHU  A 403 (-3.6A)
ANP  A 401 (-3.0A)
MG  A 402 ( 2.9A)
MG  A 402 (-3.2A)
CHU  A 403 ( 3.3A)
CHU  A 403 ( 4.0A)
0.48A94.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		4agu CYCLIN-DEPENDENT
KINASE-LIKE 1
(Homo
sapiens)		6 / 12LEU A  78
LEU A  55
ASP A 126
LYS A 128
ASN A 131
GLY A 146
None
None
None
D15  A 500 ( 4.8A)
D15  A 500 (-3.0A)
None
1.48A28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens)		6 / 12LEU A 281
ASP A 336
LYS A 338
ASN A 341
ASP A 354
GLY A 356
None
None
FLC  A1504 (-2.8A)
None
TAK  A1507 (-3.5A)
None
1.33A26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens)		5 / 12LYS A 235
ASP A 336
LYS A 338
ASN A 341
ASP A 354
TAK  A1507 ( 4.5A)
None
FLC  A1504 (-2.8A)
None
TAK  A1507 (-3.5A)
0.65A26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1
(Homo
sapiens)		6 / 12LYS A  49
LEU A  70
MET A  95
ASP A 141
LYS A 143
ASN A 146
ATP  A 401 (-3.0A)
None
ATP  A 401 ( 4.3A)
ATP  A 401 ( 4.6A)
None
ATP  A 401 (-3.4A)
1.05A26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens)		5 / 12LYS A 402
MET A 448
ASN A 499
ASP A 512
GLY A 514
ANP  A 701 (-2.7A)
ANP  A 701 ( 3.7A)
MG  A 702 ( 3.0A)
MG  A 702 ( 3.1A)
None
0.56A17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens)		6 / 12MET A 227
ASP A 274
LYS A 276
ASN A 279
ASP A 292
VAL A 201
0XZ  A 501 (-3.8A)
None
0XZ  A 501 ( 4.4A)
0XZ  A 501 ( 4.5A)
0XZ  A 501 ( 3.4A)
None
1.19A25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens)		5 / 12ILE A 467
MET A 469
ASP A 515
LYS A 517
ASN A 520
None
T28  A 701 (-2.6A)
None
None
T28  A 701 ( 4.9A)
0.63A26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens)		6 / 12LYS A 429
LEU A 441
ILE A 467
ASN A 520
ASP A 534
GLY A 558
T28  A 701 ( 3.8A)
None
None
T28  A 701 ( 4.9A)
T28  A 701 ( 3.4A)
None
1.46A26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens)		6 / 12LYS A 429
LEU A 441
ILE A 467
ASP A 515
ASN A 520
ASP A 534
T28  A 701 ( 3.8A)
None
None
None
T28  A 701 ( 4.9A)
T28  A 701 ( 3.4A)
1.15A26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens)		6 / 12LYS A 429
LEU A 441
ILE A 467
MET A 469
ASN A 520
GLY A 558
T28  A 701 ( 3.8A)
None
None
T28  A 701 (-2.6A)
T28  A 701 ( 4.9A)
None
1.31A26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens)		6 / 12LYS A 429
LEU A 441
ILE A 467
MET A 469
ASP A 515
ASN A 520
T28  A 701 ( 3.8A)
None
None
T28  A 701 (-2.6A)
None
T28  A 701 ( 4.9A)
0.94A26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens)		6 / 12LYS A 429
LEU A 441
LEU A 455
ILE A 467
ASP A 515
ASP A 534
T28  A 701 ( 3.8A)
None
None
None
None
T28  A 701 ( 3.4A)
1.40A26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens)		6 / 12LYS A 295
ILE A 336
ASP A 386
ASN A 391
ASP A 404
GLY A 406
0J9  A 601 ( 4.7A)
0J9  A 601 (-4.4A)
None
None
0J9  A 601 (-3.1A)
None
0.57A22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens)		5 / 12LEU A 432
ASP A 504
LYS A 506
ASN A 509
ASP A 522
None
None
None
PZW  A 801 (-4.4A)
PZW  A 801 (-3.2A)
0.74A27.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		4uy9 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens)		6 / 12LEU A 218
ASP A 268
LYS A 270
ASN A 273
ASP A 294
GLY A 296
None
1.21A27.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens)		5 / 12LYS A 127
MET A 175
ASP A 221
LYS A 223
ASN A 226
ATP  A 501 (-2.6A)
ATP  A 501 (-3.6A)
ATP  A 501 (-4.2A)
ATP  A 501 (-2.7A)
ZN  A 502 ( 2.5A)
0.67A24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens)		5 / 12ILE A 124
MET A 126
ASP A 176
LYS A 178
ASN A 181
None
KSA  A 405 ( 3.7A)
ZN  A 403 (-3.2A)
ZN  A 403 ( 4.3A)
KSA  A 405 (-4.0A)
0.70A26.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		4yc6 CYCLIN-DEPENDENT
KINASE 1
(Homo
sapiens)		6 / 12LEU A  66
ASP A 128
LYS A 130
ASN A 133
ASP A 146
GLY A 148
None
1.17A30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		4yc6 CYCLIN-DEPENDENT
KINASE 1
(Homo
sapiens)		6 / 12LYS A  33
ASP A 128
LYS A 130
ASN A 133
ASP A 146
GLY A 148
None
0.98A30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		4yc6 CYCLIN-DEPENDENT
KINASE 1
(Homo
sapiens)		6 / 12LYS A  33
LEU A  55
ASP A 128
LYS A 130
ASN A 133
ASP A 146
None
1.09A30.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens)		6 / 12LEU A 616
ILE A 640
ASP A 688
LYS A 690
ASN A 693
ASP A 711
None
1.03A24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens)		6 / 12LEU A 616
ILE A 642
ASP A 688
LYS A 690
ASN A 693
ASP A 711
None
1.44A24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT
(Homo
sapiens)		6 / 12LYS A  45
LEU A  57
ASP A 133
LYS A 135
ASN A 138
ASP A 151
032  A 401 (-4.4A)
032  A 401 ( 4.7A)
None
None
None
032  A 401 (-4.6A)
0.97A24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT
(Homo
sapiens)		6 / 12LYS A  45
LEU A  57
ASP A 133
LYS A 135
ASN A 138
ASP A 151
032  A 401 (-4.4A)
032  A 401 ( 4.7A)
None
None
None
032  A 401 (-4.6A)
1.34A24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT
(Homo
sapiens)		6 / 12LYS A  45
LEU A  57
ILE A  80
ASP A 133
LYS A 135
ASN A 138
032  A 401 (-4.4A)
032  A 401 ( 4.7A)
032  A 401 (-4.0A)
None
None
None
0.89A24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT
(Homo
sapiens)		6 / 12LYS A  45
LEU A  57
ILE A  80
ASP A 133
LYS A 135
ASN A 138
032  A 401 (-4.4A)
032  A 401 ( 4.7A)
032  A 401 (-4.0A)
None
None
None
1.35A24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens)		6 / 12LYS A  79
ILE A 128
ASP A 180
LYS A 182
ASN A 185
ASP A 198
IDV  A 401 ( 4.8A)
None
None
IDV  A 401 ( 4.2A)
IDV  A 401 (-4.1A)
IDV  A 401 (-4.0A)
1.03A27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens)		6 / 12LYS A  79
ILE A 128
MET A 130
ASP A 180
LYS A 182
ASN A 185
IDV  A 401 ( 4.8A)
None
IDV  A 401 (-3.4A)
None
IDV  A 401 ( 4.2A)
IDV  A 401 (-4.1A)
0.79A27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		5j0a LYMPHOKINE-ACTIVATED
KILLER
T-CELL-ORIGINATED
PROTEIN KINASE
(Homo
sapiens)		6 / 12LEU A  89
LEU A  92
ASP A 167
LYS A 169
ASN A 172
ASP A 186
None
1.27A26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens)		6 / 12LEU A 140
ASP A 225
LYS A 227
ASN A 230
ASP A 541
GLY A 543
None
None
None
None
DMS  A 717 (-4.3A)
None
1.39A25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens)		5 / 12LEU A 128
ASP A 213
LYS A 215
ASN A 218
ASP A 497
None
EDO  A 702 ( 4.9A)
None
None
EMH  A 705 (-4.7A)
0.73A14.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3
(Homo
sapiens)		6 / 12LYS A  56
ILE A  97
MET A  99
LYS A 148
ASN A 151
ASP A 164
ANP  A 501 (-2.4A)
None
ANP  A 501 (-2.5A)
ANP  A 501 (-3.1A)
ANP  A 501 ( 2.6A)
MG  A 502 ( 3.1A)
0.60A33.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4
(Homo
sapiens)		6 / 12LEU A 215
LEU A 260
ASP A 311
LYS A 313
ASN A 316
GLY A 331
None
1.27A14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		1fs2 SKP2
(Homo
sapiens)		4 / 4ASN A 236
SER A 224
LEU A 225
THR A 262
None
1.36A21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		1mox EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens)		4 / 4ASN A  40
SER A  99
LEU A  98
THR A  10
None
1.30A21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		1p9m INTERLEUKIN-6
RECEPTOR BETA CHAIN
(Homo
sapiens)		4 / 4ASN A 236
SER A 207
LEU A 206
THR A 255
None
1.20A21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1
(Homo
sapiens)		4 / 4ASN A  72
SER A 523
LEU A 158
THR A  39
None
1.48A21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		1yz4 DUAL SPECIFICITY
PHOSPHATASE-LIKE 15
ISOFORM A
(Homo
sapiens)		4 / 4ASN A  83
SER A  95
LEU A  14
THR A  32
None
SO4  A 211 ( 4.5A)
None
None
1.39A21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2
(Homo
sapiens)		4 / 4ASN B2224
SER B2212
LEU B2213
THR B2250
None
1.28A21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		2gtr CHROMODOMAIN Y-LIKE
PROTEIN
(Homo
sapiens)		4 / 4ASN A  31
SER A 118
LEU A 115
THR A  22
None
1.46A22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		3d3m EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens)		4 / 4ASN A 770
SER A 759
LEU A 762
THR A 774
None
1.14A19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens)		4 / 4ASN A 233
SER A 222
LEU A 225
THR A 237
None
1.16A23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		3rpi LIGHT CHAIN FROM
HIGHLY POTENT
ANTI-HIV
NEUTRALIZING
ANTIBODY
(Homo
sapiens)		4 / 4ASN L 126
SER L 191
LEU L 190
THR L 161
None
1.43A22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		3rpi LIGHT CHAIN FROM
HIGHLY POTENT
ANTI-HIV
NEUTRALIZING
ANTIBODY
(Homo
sapiens)		4 / 4ASN L 127
SER L 191
LEU L 190
THR L 161
None
1.49A22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		3tht ALKYLATED DNA REPAIR
PROTEIN ALKB HOMOLOG
8
(Homo
sapiens)		4 / 4ASN A  49
SER A  93
LEU A  45
THR A 114
None
1.45A23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		3v98 ARACHIDONATE
5-LIPOXYGENASE
(Homo
sapiens)		4 / 4ASN A 407
SER A 608
LEU A 607
THR A 403
None
1.37A18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		4jhp X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR
(Homo
sapiens)		4 / 4ASN C 107
SER C 152
LEU C 100
THR C 137
None
1.47A20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		5utk ANGIOPOIETIN-1
RECEPTOR
(Homo
sapiens)		4 / 4ASN A 560
SER A 666
LEU A 634
THR A 562
None
1.43A22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		6c01 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 3
(Homo
sapiens)		4 / 4ASN A 594
SER A 632
LEU A 625
THR A 596
NAG  A 925 (-1.9A)
None
None
NAG  A 925 (-4.2A)
1.11A13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		1m9i ANNEXIN VI
(Homo
sapiens)		5 / 12LEU A 119
LEU A 115
ILE A 101
ASP A 145
LEU A 162
None
0.89A19.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2
(Homo
sapiens)		12 / 12LYS A 101
LEU A 119
LEU A 122
ILE A 145
MET A 147
ASN A 199
ASP A 212
PHE A 213
GLY A 214
SER A 216
LEU A 219
MET A 223
ATP  A 535 ( 2.5A)
5EA  A1001 (-4.9A)
5EA  A1001 (-4.9A)
5EA  A1001 ( 3.7A)
ATP  A 535 ( 3.4A)
MG  A 536 (-2.8A)
MG  A 536 (-3.3A)
5EA  A1001 (-3.6A)
5EA  A1001 (-3.6A)
5EA  A1001 (-4.5A)
5EA  A1001 ( 3.9A)
5EA  A1001 (-4.2A)
0.44A82.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		1tye INTEGRIN BETA-3
(Homo
sapiens)		5 / 12LEU B 246
LEU B 306
MET B 295
PHE B 308
LEU B 117
None
1.00A21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens)		6 / 12LEU A 370
ILE A 353
PHE A 487
GLY A 431
LEU A 433
MET A 437
None
1.35A26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		2a1a INTERFERON-INDUCED,
DOUBLE-STRANDED
RNA-ACTIVATED
PROTEIN KINASE
(Homo
sapiens)		6 / 12LYS B 296
ILE B 364
MET B 366
ASN B 419
ASP B 432
PHE B 433
None
1.31A26.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		2bex RIBONUCLEASE
INHIBITOR
(Homo
sapiens)		5 / 12LEU A  62
LEU A  67
ILE A  47
GLY A  38
LEU A  34
None
0.86A22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens)		5 / 12LYS A 295
ILE A 336
ASN A 391
ASP A 404
PHE A 405
H8H  A 534 (-3.7A)
H8H  A 534 ( 4.5A)
H8H  A 534 ( 4.9A)
H8H  A 534 (-4.2A)
None
0.80A22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens)		5 / 12LYS A 295
ILE A 336
ASN A 391
PHE A 405
GLY A 406
H8H  A 534 (-3.7A)
H8H  A 534 ( 4.5A)
H8H  A 534 ( 4.9A)
None
None
0.87A22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		2hck HEMATOPOETIC CELL
KINASE HCK
(Homo
sapiens)		7 / 12LYS A 295
LEU A 325
ILE A 336
ASN A 391
ASP A 404
PHE A 405
GLY A 406
None
0.95A22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens)		5 / 12LYS A 369
MET A 414
ASN A 466
ASP A 479
PHE A 480
ANP  A 615 (-3.1A)
ANP  A 615 ( 3.9A)
ANP  A 615 ( 3.3A)
MG  A 614 ( 3.2A)
None
0.71A20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		3feg CHOLINE/ETHANOLAMINE
KINASE
(Homo
sapiens)		6 / 12LEU A 260
LEU A 262
ILE A 167
MET A 171
GLY A 246
LEU A 153
None
1.43A23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		3kex RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3
(Homo
sapiens)		5 / 12LYS A 723
ASN A 820
ASP A 833
PHE A 834
LEU A 839
ANP  A   1 (-3.4A)
ANP  A   1 ( 2.6A)
MG  A1001 ( 3.1A)
None
None
0.83A24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens)		6 / 12LEU A  84
ASN A 163
ASP A 179
PHE A 180
GLY A 181
LEU A  64
QUE  A   1 ( 4.6A)
None
QUE  A   1 (-2.9A)
None
None
None
1.27A26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens)		5 / 12LYS A 721
ASN A 818
ASP A 831
PHE A 832
GLY A 833
ITI  A   1 (-2.6A)
None
ITI  A   1 ( 4.6A)
ITI  A   1 (-3.6A)
None
0.92A23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens)		6 / 12LEU A 312
LEU A 299
ILE A 295
GLY A 372
LEU A 374
MET A 378
None
1.44A20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens)		5 / 12LYS A1114
ASN A1213
ASP A1226
PHE A1227
GLY A1228
ANP  A1358 (-3.2A)
MG  A   1 ( 2.9A)
MG  A   1 ( 3.2A)
None
None
0.98A22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens)		5 / 12LEU A 200
ILE A 186
GLY A 175
SER A 177
LEU A 180
None
1.03A20.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		3vn9 DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6
(Homo
sapiens)		5 / 12LYS A  82
ILE A 127
MET A 129
ASN A 184
ASP A 197
ANK  A 401 (-2.4A)
None
ANK  A 401 (-3.7A)
ANK  A 401 ( 2.7A)
MG  A 402 ( 2.8A)
0.68A35.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens)		12 / 12LYS A  98
LEU A 116
LEU A 119
ILE A 142
MET A 144
ASN A 196
ASP A 209
PHE A 210
GLY A 211
SER A 213
LEU A 216
MET A 220
ANP  A 401 (-2.7A)
None
CHU  A 403 (-4.4A)
CHU  A 403 (-3.8A)
CHU  A 403 (-3.8A)
MG  A 402 ( 2.9A)
MG  A 402 (-3.2A)
CHU  A 403 (-3.8A)
CHU  A 403 ( 3.3A)
CHU  A 403 (-4.7A)
CHU  A 403 (-4.1A)
CHU  A 403 (-3.6A)
0.42A90.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens)		6 / 12LYS A 402
MET A 448
ASN A 499
ASP A 512
GLY A 514
LEU A 519
ANP  A 701 (-2.7A)
ANP  A 701 ( 3.7A)
MG  A 702 ( 3.0A)
MG  A 702 ( 3.1A)
None
None
1.01A19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens)		6 / 12LYS A 402
MET A 448
ASN A 499
ASP A 512
PHE A 513
GLY A 514
ANP  A 701 (-2.7A)
ANP  A 701 ( 3.7A)
MG  A 702 ( 3.0A)
MG  A 702 ( 3.1A)
None
None
0.72A19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens)		5 / 12LEU A 365
ILE A 385
ASN A 704
GLY A 643
LEU A 637
None
1.02A22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		4hzs ACTIVATED CDC42
KINASE 1
(Homo
sapiens)		5 / 12LYS A 158
ASN A 257
ASP A 270
PHE A 271
GLY A 272
None
0.84A25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens)		6 / 12LYS A 295
ILE A 336
ASN A 391
ASP A 404
PHE A 405
GLY A 406
0J9  A 601 ( 4.7A)
0J9  A 601 (-4.4A)
None
0J9  A 601 (-3.1A)
None
None
0.58A21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens)		5 / 12LEU A  81
ASN A 161
ASP A 175
PHE A 176
GLY A 177
None
None
1UL  A 501 (-4.2A)
None
None
0.98A28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens)		5 / 12LEU A  81
MET A 104
ASN A 161
PHE A 176
GLY A 177
None
1UL  A 501 (-3.6A)
None
None
None
0.89A28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		4s3o E3 UBIQUITIN-PROTEIN
LIGASE RING2
POLYCOMB GROUP RING
FINGER PROTEIN 5
(Homo
sapiens)		6 / 12LEU B  45
LEU B  49
ILE B 113
ASN B 105
PHE B 106
LEU C  82
None
1.35A16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		4yc6 CYCLIN-DEPENDENT
KINASE 1
(Homo
sapiens)		5 / 12LEU A  66
ASN A 133
ASP A 146
PHE A 147
GLY A 148
None
0.97A29.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		4yc6 CYCLIN-DEPENDENT
KINASE 1
(Homo
sapiens)		5 / 12LYS A  33
ASN A 133
ASP A 146
PHE A 147
GLY A 148
None
0.95A29.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens)		5 / 12LEU A 616
ILE A 642
ASN A 693
ASP A 711
PHE A 712
None
0.91A24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens)		6 / 12LEU A  90
LEU A  67
ASN A 143
ASP A 165
GLY A 167
LEU A  60
None
None
GOL  A 404 ( 4.6A)
GOL  A 404 (-3.2A)
None
None
1.33A26.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens)		5 / 12LEU A  73
ASN A 158
ASP A 171
PHE A 172
GLY A 173
LEU  A  73 ( 0.6A)
ASN  A 158 ( 0.6A)
ASP  A 171 ( 0.5A)
PHE  A 172 ( 1.3A)
GLY  A 173 ( 0.0A)
0.72A30.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens)		5 / 12MET A 105
ASN A 158
ASP A 171
PHE A 172
GLY A 173
MET  A 105 (-0.0A)
ASN  A 158 ( 0.6A)
ASP  A 171 ( 0.5A)
PHE  A 172 ( 1.3A)
GLY  A 173 ( 0.0A)
1.00A30.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens)		6 / 12LYS A  79
ILE A 128
MET A 130
ASN A 185
ASP A 198
PHE A 199
IDV  A 401 ( 4.8A)
None
IDV  A 401 (-3.4A)
IDV  A 401 (-4.1A)
IDV  A 401 (-4.0A)
None
1.19A27.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		5mc7 COATOMER SUBUNIT
ZETA-1
(Homo
sapiens)		5 / 12LEU A 114
ILE A  18
PHE A 122
GLY A 120
LEU A 101
None
1.03A19.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3
(Homo
sapiens)		6 / 12LYS A  56
ILE A  97
MET A  99
ASN A 151
ASP A 164
PHE A 165
ANP  A 501 (-2.4A)
None
ANP  A 501 (-2.5A)
ANP  A 501 ( 2.6A)
MG  A 502 ( 3.1A)
None
0.59A30.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		1kcw CERULOPLASMIN
(Homo
sapiens)		3 / 3ASP A 372
VAL A 388
ASN A 611
None
0.81A15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		1mox EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens)		3 / 3ASP A 155
VAL A 124
ASN A 128
None
0.80A21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		1t8t HEPARAN SULFATE
D-GLUCOSAMINYL
3-O-SULFOTRANSFERASE
3A1
(Homo
sapiens)		3 / 3ASP A 244
VAL A 241
ASN A 391
None
0.78A20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		2gpv ESTROGEN-RELATED
RECEPTOR GAMMA
(Homo
sapiens)		3 / 3ASP A 322
VAL A 325
ASN A 347
None
0.71A21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		2p2c CASPASE-2
(Homo
sapiens)		3 / 3ASP P  44
VAL B 246
ASN P  78
None
0.64A18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		2wt8 MICROCEPHALIN
(Homo
sapiens)		3 / 3ASP A  54
VAL A  13
ASN A  95
None
0.78A15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		2yt4 PROTEIN DGCR8
(Homo
sapiens)		3 / 3ASP A 579
VAL A 504
ASN A 599
None
0.77A22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		3l6r SERINE RACEMASE
(Homo
sapiens)		3 / 3ASP A 132
VAL A 138
ASN A 154
None
None
LLP  A  56 ( 4.7A)
0.81A24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		3p5b LOW DENSITY
LIPOPROTEIN RECEPTOR
VARIANT
(Homo
sapiens)		3 / 3ASP L 461
VAL L 415
ASN L 644
None
0.70A22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		4az3 LYSOSOMAL PROTECTIVE
PROTEIN 20 KDA CHAIN
(Homo
sapiens)		3 / 3ASP B 380
VAL B 413
ASN B 376
None
0.80A17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		4cem REGULATOR OF
NONSENSE TRANSCRIPTS
2
(Homo
sapiens)		3 / 3ASP A 265
VAL A 308
ASN A 258
None
0.79A20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		4lik DNA PRIMASE SMALL
SUBUNIT
(Homo
sapiens)		3 / 3ASP A 232
VAL A 118
ASN A 236
None
0.62A23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens)		3 / 3ASP A 380
VAL A 413
ASN A 376
ASP  A 380 ( 0.5A)
VAL  A 413 ( 0.6A)
ASN  A 376 ( 0.6A)
0.76A25.22