POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.


DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)
1ijt FIBROBLAST GROWTH
FACTOR 4
(Homo
sapiens)
5 / 9SER A 194
ALA A 168
VAL A 199
ALA A 180
GLY A 190
None
1.15A10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)
2a8i THREONINE ASPARTASE
1
(Homo
sapiens)
5 / 9ALA A 101
ALA A 266
SER A 251
VAL A 130
GLY A 264
None
1.15A4.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)
2f9q CYTOCHROME P450 2D6
(Homo
sapiens)
5 / 9ALA A 127
SER A 289
VAL A 119
ALA A 122
VAL A 298
None
None
HEM  A 600 (-4.6A)
None
None
0.98A4.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)
2ibu ACETYL-COA
ACETYLTRANSFERASE
(Homo
sapiens)
5 / 9ALA A 333
ALA A 410
SER A 411
VAL A 374
GLY A 408
None
1.17A3.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)
4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens)
5 / 9ALA A 419
SER A 420
VAL A 390
ALA A 392
GLY A 426
ZN  A1001 ( 4.2A)
None
BES  A1017 ( 3.7A)
None
None
1.10A3.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)
4xib E3 UBIQUITIN-PROTEIN
LIGASE MIB1
(Homo
sapiens)
5 / 9SER A 213
VAL A  49
SER A  41
VAL A  51
GLY A  15
None
1.23A7.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)
5lf9 NUCLEOSIDE
DIPHOSPHATE-LINKED
MOIETY X MOTIF 22
(Homo
sapiens)
5 / 9SER A 275
VAL A 123
ALA A 222
SER A 221
GLY A 209
None
1.24A6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)
5ulm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens)
5 / 9VAL A 494
ALA A 497
SER A 498
VAL A 486
GLY A 479
None
1.03A5.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)
5zya SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens)
5 / 9ALA C 601
VAL C 634
ALA C 636
SER C 637
GLY C 640
None
1.16Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2
(Homo
sapiens)
5 / 9SER A 440
ALA A 444
SER A 443
ALA A 520
SER A 521
None
0.89Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)
2d8i T-CELL LYMPHOMA
INVASION AND
METASTASIS 1 VARIANT
(Homo
sapiens)
5 / 9ALA A  64
SER A  50
ALA A  57
SER A  58
GLY A  61
None
1.20A15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)
2eyz V-CRK SARCOMA VIRUS
CT10 ONCOGENE
HOMOLOG ISOFORM A
(Homo
sapiens)
5 / 9SER A  43
SER A  83
GLY A  81
SER A  85
GLY A  66
None
1.20A6.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)
2j6l ALDEHYDE
DEHYDROGENASE FAMILY
7 MEMBER A1
(Homo
sapiens)
5 / 9ALA A 233
GLY A 231
ALA A  56
GLY A 226
SER A  57
None
NAI  A1501 (-3.4A)
None
None
None
1.19A6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)
2qqk NEUROPILIN-2
(Homo
sapiens)
5 / 9ALA A 390
ALA A 419
GLY A 346
GLY A 317
SER A 349
None
1.12A3.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)
2qqo NEUROPILIN-2
(Homo
sapiens)
5 / 9ALA A 390
ALA A 419
GLY A 346
GLY A 317
SER A 349
None
TRS  A 602 ( 4.7A)
None
None
None
1.12A4.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)
3hhd FATTY ACID SYNTHASE
(Homo
sapiens)
5 / 9ALA A 340
ALA A 292
ALA A 214
GLY A 294
SER A 327
None
1.18A2.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)
3ihj ALANINE
AMINOTRANSFERASE 2
(Homo
sapiens)
5 / 9ALA A 187
SER A 338
GLY A 352
SER A 188
GLY A 190
PLP  A   1 (-3.6A)
PLP  A   1 (-2.6A)
None
PLP  A   1 (-2.7A)
None
1.19A5.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)
3snh DYNAMIN-1
(Homo
sapiens)
5 / 9ALA A  42
SER A  41
ALA A 186
GLY A  38
SER A 184
None
1.22A2.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)
3snh DYNAMIN-1
(Homo
sapiens)
5 / 9ALA A  42
SER A  41
ALA A 186
GLY A  38
SER A 184
None
1.22A2.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)
3v30 DNA-BINDING PROTEIN
RFXANK
(Homo
sapiens)
5 / 9ALA A 208
ALA A 197
ALA A 164
SER A 165
GLY A 168
None
1.11A9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)
4m9p FILAMIN-A
(Homo
sapiens)
5 / 9ALA A 595
SER A 594
GLY A 589
SER A 748
GLY A 750
None
1.14A7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)
4qdr NEUROPILIN-2
(Homo
sapiens)
5 / 9ALA A 390
ALA A 419
GLY A 346
GLY A 317
SER A 349
None
1.17A6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)
4rg1 C9ORF114
(Homo
sapiens)
5 / 9ALA A 323
GLY A 320
ALA A 272
SER A 271
SER A 268
None
1.04A5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)
4wgk NEUTRAL CERAMIDASE
(Homo
sapiens)
5 / 9ALA A 344
ALA A 141
ALA A 109
SER A 230
GLY A 107
None
1.22A3.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)
5dn2 NEUROPILIN-2
(Homo
sapiens)
5 / 9ALA A 390
ALA A 419
GLY A 346
GLY A 317
SER A 349
None
1.15A11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2
(Homo
sapiens)
5 / 9ALA A 444
SER A 443
ALA A 520
SER A 521
SER A 440
None
0.86Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2
(Homo
sapiens)
5 / 9SER A 440
ALA A 444
SER A 443
ALA A 520
SER A 521
None
0.91Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)
1wao SERINE/THREONINE
PROTEIN PHOSPHATASE
5
(Homo
sapiens)
4 / 6ALA 1  81
SER 1  69
ALA 1 104
SER 1 105
None
1.00A4.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)
2bug SERINE/THREONINE
PROTEIN PHOSPHATASE
5
(Homo
sapiens)
4 / 6ALA A  81
SER A  69
ALA A 104
SER A 105
None
0.81A13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)
2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens)
4 / 6ALA A 240
SER A 237
ALA A 213
SER A 214
None
NDP  A 600 (-3.0A)
None
NDP  A 600 (-2.7A)
1.05A7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)
3qt2 INTERLEUKIN-5
RECEPTOR SUBUNIT
ALPHA
(Homo
sapiens)
4 / 6SER A  77
ALA A  51
ALA A  76
SER A  75
BGC  A 317 (-3.6A)
None
None
None
1.05A4.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)
4lg8 PRE-MRNA-PROCESSING
FACTOR 19
(Homo
sapiens)
4 / 6SER A 492
SER A 498
ALA A 211
SER A 212
None
1.03A6.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens)
4 / 6SER A3002
ALA A3080
ALA A2625
SER A2624
None
0.96A0.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens)
4 / 6SER C1657
ALA C1680
SER C1677
ALA C1650
None
1.03A0.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2
(Homo
sapiens)
5 / 6SER A 440
ALA A 444
SER A 443
ALA A 520
SER A 521
None
0.90Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2
(Homo
sapiens)
4 / 6SER A 440
SER A 443
ALA A 520
SER A 521
None
0.93Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2
(Homo
sapiens)
4 / 6SER A 521
SER A 440
ALA A 444
SER A 443
None
0.91Aundetectable