POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Seq. Identity (%)	View	Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1CIL_A_ETSA263_1 (CARBONIC ANHYDRASE II)	1jd0	CARBONIC ANHYDRASE XII (Homo sapiens)	11 / 12	HIS A  64 GLN A  92 HIS A  94 HIS A  96 HIS A 119 VAL A 121 VAL A 143 LEU A 198 THR A 199 THR A 200 TRP A 209	None AZM  A1400 (-3.2A) ZN  A 901 ( 3.2A) ZN  A 901 ( 3.2A) ZN  A 901 ( 3.1A) AZM  A1400 (-4.6A) AZM  A1400 ( 4.9A) AZM  A1400 (-3.9A) AZM  A1400 (-3.6A) AZM  A1400 (-3.3A) None	0.32A	36.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1CIL_A_ETSA263_1 (CARBONIC ANHYDRASE II)	1jd0	CARBONIC ANHYDRASE XII (Homo sapiens)	6 / 12	HIS A  64 HIS A  96 VAL A 143 LEU A 198 THR A 199 THR A 200	None ZN  A 901 ( 3.2A) AZM  A1400 ( 4.9A) AZM  A1400 (-3.9A) AZM  A1400 (-3.6A) AZM  A1400 (-3.3A)	1.19A	36.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1CIL_A_ETSA263_1 (CARBONIC ANHYDRASE II)	2it4	CARBONIC ANHYDRASE 1 (Homo sapiens)	8 / 12	GLN A  92 HIS A  94 HIS A  96 HIS A 119 VAL A 143 LEU A 198 THR A 199 TRP A 209	None ZN  A 561 ( 3.2A) ZN  A 561 ( 3.2A) ZN  A 561 ( 3.1A) PPF  A 500 (-4.9A) PPF  A 500 (-3.9A) PPF  A 500 (-3.6A) None	0.50A	60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1CIL_A_ETSA263_1 (CARBONIC ANHYDRASE II)	2it4	CARBONIC ANHYDRASE 1 (Homo sapiens)	5 / 12	HIS A  96 HIS A 119 VAL A 143 LEU A 198 THR A 199	ZN  A 561 ( 3.2A) ZN  A 561 ( 3.1A) PPF  A 500 (-4.9A) PPF  A 500 (-3.9A) PPF  A 500 (-3.6A)	1.02A	60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1CIL_A_ETSA263_1 (CARBONIC ANHYDRASE II)	2w2j	CARBONIC ANHYDRASE-RELATED PROTEIN (Homo sapiens)	6 / 12	HIS A  87 HIS A 118 HIS A 141 LEU A 222 THR A 223 TRP A 233	None CL  A 401 (-4.2A) CL  A 401 (-4.1A) None CL  A 401 ( 4.8A) None	0.30A	38.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1CIL_A_ETSA263_1 (CARBONIC ANHYDRASE II)	3da2	CARBONIC ANHYDRASE 13 (Homo sapiens)	6 / 12	HIS A  65 GLN A  93 HIS A  95 HIS A  97 LEU A 199 THR A 200	None 4MD  A 401 (-3.1A) ZN  A 301 ( 3.6A) ZN  A 301 ( 3.5A) 4MD  A 401 (-4.2A) 4MD  A 401 (-3.2A)	0.89A	59.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1CIL_A_ETSA263_1 (CARBONIC ANHYDRASE II)	3da2	CARBONIC ANHYDRASE 13 (Homo sapiens)	6 / 12	HIS A  65 GLN A  93 HIS A  97 PHE A 132 LEU A 199 THR A 200	None 4MD  A 401 (-3.1A) ZN  A 301 ( 3.5A) 4MD  A 401 (-4.6A) 4MD  A 401 (-4.2A) 4MD  A 401 (-3.2A)	0.89A	59.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1CIL_A_ETSA263_1 (CARBONIC ANHYDRASE II)	3da2	CARBONIC ANHYDRASE 13 (Homo sapiens)	9 / 12	HIS A  65 HIS A  95 HIS A  97 HIS A 120 VAL A 122 VAL A 144 LEU A 199 THR A 200 TRP A 210	None ZN  A 301 ( 3.6A) ZN  A 301 ( 3.5A) ZN  A 301 ( 3.2A) 4MD  A 401 ( 4.6A) 4MD  A 401 ( 4.4A) 4MD  A 401 (-4.2A) 4MD  A 401 (-3.2A) None	0.42A	59.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1CIL_A_ETSA263_1 (CARBONIC ANHYDRASE II)	3da2	CARBONIC ANHYDRASE 13 (Homo sapiens)	9 / 12	HIS A  65 HIS A  97 HIS A 120 VAL A 122 PHE A 132 VAL A 144 LEU A 199 THR A 200 TRP A 210	None ZN  A 301 ( 3.5A) ZN  A 301 ( 3.2A) 4MD  A 401 ( 4.6A) 4MD  A 401 (-4.6A) 4MD  A 401 ( 4.4A) 4MD  A 401 (-4.2A) 4MD  A 401 (-3.2A) None	0.29A	59.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1CIL_A_ETSA263_1 (CARBONIC ANHYDRASE II)	3e0l	GUANINE DEAMINASE (Homo sapiens)	5 / 12	GLN A  87 HIS A  84 HIS A  82 PHE A 108 VAL A 169	None ZN  A1452 (-3.1A) ZN  A1452 (-3.3A) None None	1.07A	20.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1CIL_A_ETSA263_1 (CARBONIC ANHYDRASE II)	3fe4	CARBONIC ANHYDRASE 6 (Homo sapiens)	10 / 12	HIS A  85 GLN A 109 HIS A 111 HIS A 113 HIS A 138 VAL A 140 VAL A 161 LEU A 219 THR A 220 TRP A 230	None None MG  A 901 (-3.4A) MG  A 901 (-3.4A) MG  A 901 (-3.2A) None None None None None	0.71A	34.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1CIL_A_ETSA263_1 (CARBONIC ANHYDRASE II)	3fe4	CARBONIC ANHYDRASE 6 (Homo sapiens)	6 / 12	HIS A 111 HIS A 113 VAL A 140 VAL A 161 LEU A 219 THR A 220	MG  A 901 (-3.4A) MG  A 901 (-3.4A) None None None None	1.45A	34.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1CIL_A_ETSA263_1 (CARBONIC ANHYDRASE II)	3ml5	CARBONIC ANHYDRASE 7 (Homo sapiens)	6 / 12	GLN A  67 HIS A  94 HIS A  96 LEU A 198 THR A 199 THR A 200	None ZN  A 263 ( 3.2A) ZN  A 263 ( 3.2A) AZM  A 264 (-3.4A) AZM  A 264 (-3.4A) AZM  A 264 (-3.5A)	1.09A	55.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1CIL_A_ETSA263_1 (CARBONIC ANHYDRASE II)	3ml5	CARBONIC ANHYDRASE 7 (Homo sapiens)	6 / 12	GLN A  67 HIS A  96 VAL A 121 LEU A 198 THR A 199 THR A 200	None ZN  A 263 ( 3.2A) AZM  A 264 (-4.7A) AZM  A 264 (-3.4A) AZM  A 264 (-3.4A) AZM  A 264 (-3.5A)	1.23A	55.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1CIL_A_ETSA263_1 (CARBONIC ANHYDRASE II)	3ml5	CARBONIC ANHYDRASE 7 (Homo sapiens)	7 / 12	GLN A  92 HIS A  94 HIS A  96 VAL A 121 PHE A 131 LEU A 198 THR A 199	AZM  A 264 (-4.1A) ZN  A 263 ( 3.2A) ZN  A 263 ( 3.2A) AZM  A 264 (-4.7A) AZM  A 264 (-4.4A) AZM  A 264 (-3.4A) AZM  A 264 (-3.4A)	1.37A	55.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1CIL_A_ETSA263_1 (CARBONIC ANHYDRASE II)	3ml5	CARBONIC ANHYDRASE 7 (Homo sapiens)	8 / 12	HIS A   2 GLN A  92 VAL A 121 VAL A 143 LEU A 198 THR A 199 THR A 200 TRP A 209	None AZM  A 264 (-4.1A) AZM  A 264 (-4.7A) AZM  A 264 ( 4.9A) AZM  A 264 (-3.4A) AZM  A 264 (-3.4A) AZM  A 264 (-3.5A) None	1.19A	55.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1CIL_A_ETSA263_1 (CARBONIC ANHYDRASE II)	3ml5	CARBONIC ANHYDRASE 7 (Homo sapiens)	12 / 12	HIS A  64 GLN A  92 HIS A  94 HIS A  96 HIS A 119 VAL A 121 PHE A 131 VAL A 143 LEU A 198 THR A 199 THR A 200 TRP A 209	None AZM  A 264 (-4.1A) ZN  A 263 ( 3.2A) ZN  A 263 ( 3.2A) ZN  A 263 ( 3.1A) AZM  A 264 (-4.7A) AZM  A 264 (-4.4A) AZM  A 264 ( 4.9A) AZM  A 264 (-3.4A) AZM  A 264 (-3.4A) AZM  A 264 (-3.5A) None	0.39A	55.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1CIL_A_ETSA263_1 (CARBONIC ANHYDRASE II)	3uyq	CARBONIC ANHYDRASE 3 (Homo sapiens)	6 / 12	GLN A  92 HIS A  94 HIS A  96 VAL A 121 PHE A 130 THR A 198	None ZN  A 261 (-3.3A) ZN  A 261 (-3.3A) None None ZN  A 261 ( 4.4A)	1.20A	58.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1CIL_A_ETSA263_1 (CARBONIC ANHYDRASE II)	3uyq	CARBONIC ANHYDRASE 3 (Homo sapiens)	11 / 12	HIS A  64 GLN A  92 HIS A  94 HIS A  96 HIS A 119 VAL A 121 PHE A 130 VAL A 142 THR A 198 THR A 199 TRP A 208	None None ZN  A 261 (-3.3A) ZN  A 261 (-3.3A) ZN  A 261 (-3.2A) None None None ZN  A 261 ( 4.4A) None None	0.44A	58.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1CIL_A_ETSA263_1 (CARBONIC ANHYDRASE II)	4qk3	CARBONIC ANHYDRASE 2 (Homo sapiens)	11 / 12	GLN A  92 HIS A  94 HIS A  96 HIS A 119 VAL A 121 PHE A 131 VAL A 143 LEU A 198 THR A 199 THR A 200 TRP A 209	None ZN  A 301 (-3.2A) ZN  A 301 (-3.2A) ZN  A 301 (-3.1A) None None None None ZN  A 301 ( 4.4A) None None	0.31A	95.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1CIL_A_ETSA263_1 (CARBONIC ANHYDRASE II)	4qk3	CARBONIC ANHYDRASE 2 (Homo sapiens)	7 / 12	GLN A  92 HIS A  94 HIS A  96 VAL A 121 PHE A 131 LEU A 198 THR A 199	None ZN  A 301 (-3.2A) ZN  A 301 (-3.2A) None None None ZN  A 301 ( 4.4A)	1.38A	95.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1CIL_A_ETSA263_1 (CARBONIC ANHYDRASE II)	4qk3	CARBONIC ANHYDRASE 2 (Homo sapiens)	6 / 12	HIS A  94 HIS A 119 LEU A 198 THR A 199 THR A 200 TRP A 209	ZN  A 301 (-3.2A) ZN  A 301 (-3.1A) None ZN  A 301 ( 4.4A) None None	1.46A	95.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1CIL_A_ETSA263_1 (CARBONIC ANHYDRASE II)	4qk3	CARBONIC ANHYDRASE 2 (Homo sapiens)	5 / 12	HIS A  96 VAL A 121 LEU A 198 THR A 199 THR A 200	ZN  A 301 (-3.2A) None None ZN  A 301 ( 4.4A) None	0.94A	95.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1CIL_A_ETSA263_1 (CARBONIC ANHYDRASE II)	5cjf	CARBONIC ANHYDRASE 14 (Homo sapiens)	6 / 12	GLN A  67 HIS A  94 HIS A  96 LEU A 198 THR A 199 THR A 200	GOL  A 303 (-3.4A) ZN  A 301 (-3.2A) ZN  A 301 ( 3.2A) 520  A 302 (-3.6A) 520  A 302 (-3.4A) GOL  A 303 ( 3.5A)	1.08A	36.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1CIL_A_ETSA263_1 (CARBONIC ANHYDRASE II)	5cjf	CARBONIC ANHYDRASE 14 (Homo sapiens)	6 / 12	GLN A  67 HIS A  96 VAL A 121 LEU A 198 THR A 199 THR A 200	GOL  A 303 (-3.4A) ZN  A 301 ( 3.2A) 520  A 302 ( 4.9A) 520  A 302 (-3.6A) 520  A 302 (-3.4A) GOL  A 303 ( 3.5A)	1.17A	36.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1CIL_A_ETSA263_1 (CARBONIC ANHYDRASE II)	5cjf	CARBONIC ANHYDRASE 14 (Homo sapiens)	11 / 12	HIS A  64 GLN A  92 HIS A  94 HIS A  96 HIS A 119 VAL A 121 VAL A 143 LEU A 198 THR A 199 THR A 200 TRP A 209	None GOL  A 303 (-3.2A) ZN  A 301 (-3.2A) ZN  A 301 ( 3.2A) ZN  A 301 ( 3.1A) 520  A 302 ( 4.9A) 520  A 302 ( 4.9A) 520  A 302 (-3.6A) 520  A 302 (-3.4A) GOL  A 303 ( 3.5A) None	0.22A	36.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1CIL_A_ETSA263_1 (CARBONIC ANHYDRASE II)	5cjf	CARBONIC ANHYDRASE 14 (Homo sapiens)	6 / 12	HIS A  64 HIS A  96 VAL A 121 LEU A 198 THR A 199 THR A 200	None ZN  A 301 ( 3.2A) 520  A 302 ( 4.9A) 520  A 302 (-3.6A) 520  A 302 (-3.4A) GOL  A 303 ( 3.5A)	1.14A	36.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1CIL_A_ETSA263_1 (CARBONIC ANHYDRASE II)	5hly	INHIBIN BETA A CHAIN (Homo sapiens)	5 / 12	HIS A 289 VAL A 211 PHE A 221 VAL A 171 LEU A 254	None	1.17A	20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1CIL_A_ETSA263_1 (CARBONIC ANHYDRASE II)	5hlz	INHIBIN BETA A CHAIN (Homo sapiens)	5 / 12	HIS A 289 VAL A 211 PHE A 221 VAL A 171 LEU A 254	None	1.18A	24.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1CIL_A_ETSA263_1 (CARBONIC ANHYDRASE II)	5jn9	CARBONIC ANHYDRASE 4 (Homo sapiens)	10 / 12	GLN A  92 HIS A  94 HIS A  96 HIS A 119 VAL A 121 VAL A 143 LEU A 198 THR A 199 THR A 200 TRP A 209	EZL  A 302 (-4.3A) ZN  A 301 ( 3.3A) ZN  A 301 ( 3.3A) ZN  A 301 ( 3.2A) EZL  A 302 (-4.7A) EZL  A 302 ( 4.7A) EZL  A 302 (-3.5A) EZL  A 302 (-3.4A) EZL  A 302 (-3.9A) None	0.32A	35.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1CIL_A_ETSA263_1 (CARBONIC ANHYDRASE II)	5jn9	CARBONIC ANHYDRASE 4 (Homo sapiens)	6 / 12	GLN A  92 HIS A  94 HIS A  96 VAL A 121 LEU A 198 THR A 199	EZL  A 302 (-4.3A) ZN  A 301 ( 3.3A) ZN  A 301 ( 3.3A) EZL  A 302 (-4.7A) EZL  A 302 (-3.5A) EZL  A 302 (-3.4A)	1.40A	35.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1CIL_A_ETSA263_1 (CARBONIC ANHYDRASE II)	5jn9	CARBONIC ANHYDRASE 4 (Homo sapiens)	5 / 12	HIS A  64 HIS A  96 LEU A 198 THR A 199 THR A 200	None ZN  A 301 ( 3.3A) EZL  A 302 (-3.5A) EZL  A 302 (-3.4A) EZL  A 302 (-3.9A)	0.85A	35.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1CIL_A_ETSA263_1 (CARBONIC ANHYDRASE II)	5jn9	CARBONIC ANHYDRASE 4 (Homo sapiens)	5 / 12	HIS A  64 HIS A  96 VAL A 143 LEU A 198 THR A 200	None ZN  A 301 ( 3.3A) EZL  A 302 ( 4.7A) EZL  A 302 (-3.5A) EZL  A 302 (-3.9A)	1.05A	35.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1CIL_A_ETSA263_1 (CARBONIC ANHYDRASE II)	5jn9	CARBONIC ANHYDRASE 4 (Homo sapiens)	5 / 12	HIS A  94 HIS A  96 VAL A 143 LEU A 198 THR A 200	ZN  A 301 ( 3.3A) ZN  A 301 ( 3.3A) EZL  A 302 ( 4.7A) EZL  A 302 (-3.5A) EZL  A 302 (-3.9A)	1.14A	35.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1CIL_A_ETSA263_1 (CARBONIC ANHYDRASE II)	5jn9	CARBONIC ANHYDRASE 4 (Homo sapiens)	5 / 12	HIS A  96 VAL A 121 LEU A 198 THR A 199 THR A 200	ZN  A 301 ( 3.3A) EZL  A 302 (-4.7A) EZL  A 302 (-3.5A) EZL  A 302 (-3.4A) EZL  A 302 (-3.9A)	1.09A	35.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1CIL_A_ETSA263_1 (CARBONIC ANHYDRASE II)	5zqz	TRIFUNCTIONAL ENZYME SUBUNIT ALPHA, MITOCHONDRIAL (Homo sapiens)	5 / 12	HIS A 498 VAL A 591 LEU A 551 THR A 548 THR A 547	None	1.17A	16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1CIL_A_ETSA263_1 (CARBONIC ANHYDRASE II)	6fe1	CARBONIC ANHYDRASE 9 (Homo sapiens)	11 / 12	HIS A  64 GLN A  92 HIS A  94 HIS A  96 HIS A 119 VAL A 121 VAL A 143 LEU A 198 THR A 199 THR A 200 TRP A 209	None V14  A 302 (-3.8A) ZN  A 301 ( 3.2A) ZN  A 301 ( 3.2A) ZN  A 301 ( 3.1A) V14  A 302 (-4.7A) None V14  A 302 (-3.6A) V14  A 302 (-3.2A) V14  A 302 (-3.5A) None	0.39A	14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1CIL_A_ETSA263_1 (CARBONIC ANHYDRASE II)	6fe1	CARBONIC ANHYDRASE 9 (Homo sapiens)	6 / 12	HIS A  64 HIS A  96 VAL A 143 LEU A 198 THR A 199 THR A 200	None ZN  A 301 ( 3.2A) None V14  A 302 (-3.6A) V14  A 302 (-3.2A) V14  A 302 (-3.5A)	1.24A	14.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3FW3_A_ETSA302_1 (CARBONIC ANHYDRASE 4)	1jd0	CARBONIC ANHYDRASE XII (Homo sapiens)	11 / 12	ASN A  62 HIS A  64 GLN A  92 HIS A  94 HIS A  96 VAL A 121 VAL A 143 LEU A 198 THR A 199 THR A 200 TRP A 209	None None AZM  A1400 (-3.2A) ZN  A 901 ( 3.2A) ZN  A 901 ( 3.2A) AZM  A1400 (-4.6A) AZM  A1400 ( 4.9A) AZM  A1400 (-3.9A) AZM  A1400 (-3.6A) AZM  A1400 (-3.3A) None	0.26A	35.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3FW3_A_ETSA302_1 (CARBONIC ANHYDRASE 4)	1jd0	CARBONIC ANHYDRASE XII (Homo sapiens)	6 / 12	HIS A  64 HIS A  96 LEU A 198 THR A 199 THR A 200 TRP A 209	None ZN  A 901 ( 3.2A) AZM  A1400 (-3.9A) AZM  A1400 (-3.6A) AZM  A1400 (-3.3A) None	1.37A	35.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3FW3_A_ETSA302_1 (CARBONIC ANHYDRASE 4)	1jd0	CARBONIC ANHYDRASE XII (Homo sapiens)	6 / 12	HIS A 119 HIS A  96 VAL A 143 LEU A 198 THR A 199 THR A 200	ZN  A 901 ( 3.1A) ZN  A 901 ( 3.2A) AZM  A1400 ( 4.9A) AZM  A1400 (-3.9A) AZM  A1400 (-3.6A) AZM  A1400 (-3.3A)	1.43A	35.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3FW3_A_ETSA302_1 (CARBONIC ANHYDRASE 4)	2it4	CARBONIC ANHYDRASE 1 (Homo sapiens)	7 / 12	GLN A  92 HIS A  94 HIS A  96 VAL A 143 LEU A 198 THR A 199 TRP A 209	None ZN  A 561 ( 3.2A) ZN  A 561 ( 3.2A) PPF  A 500 (-4.9A) PPF  A 500 (-3.9A) PPF  A 500 (-3.6A) None	0.48A	31.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3FW3_A_ETSA302_1 (CARBONIC ANHYDRASE 4)	2w2j	CARBONIC ANHYDRASE-RELATED PROTEIN (Homo sapiens)	6 / 12	HIS A  87 HIS A 118 ILE A 163 LEU A 222 THR A 223 TRP A 233	None CL  A 401 (-4.2A) None None CL  A 401 ( 4.8A) None	0.51A	31.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FW3_A_ETSA302_1 (CARBONIC ANHYDRASE 4)	2xmr	PROTEIN NDRG2 (Homo sapiens)	5 / 12	VAL A 129 ILE A 155 VAL A 153 LEU A 289 THR A 290	None	0.91A	21.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3FW3_A_ETSA302_1 (CARBONIC ANHYDRASE 4)	3da2	CARBONIC ANHYDRASE 13 (Homo sapiens)	9 / 12	HIS A  65 GLN A  93 HIS A  95 HIS A  97 VAL A 122 VAL A 144 LEU A 199 THR A 200 TRP A 210	None 4MD  A 401 (-3.1A) ZN  A 301 ( 3.6A) ZN  A 301 ( 3.5A) 4MD  A 401 ( 4.6A) 4MD  A 401 ( 4.4A) 4MD  A 401 (-4.2A) 4MD  A 401 (-3.2A) None	0.68A	33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3FW3_A_ETSA302_1 (CARBONIC ANHYDRASE 4)	3fe4	CARBONIC ANHYDRASE 6 (Homo sapiens)	10 / 12	ASN A  83 HIS A  85 GLN A 109 HIS A 111 HIS A 113 VAL A 140 VAL A 161 LEU A 219 THR A 220 TRP A 230	None None None MG  A 901 (-3.4A) MG  A 901 (-3.4A) None None None None None	0.73A	32.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3FW3_A_ETSA302_1 (CARBONIC ANHYDRASE 4)	3ml5	CARBONIC ANHYDRASE 7 (Homo sapiens)	11 / 12	ASN A  62 HIS A  64 GLN A  92 HIS A  94 HIS A  96 VAL A 121 VAL A 143 LEU A 198 THR A 199 THR A 200 TRP A 209	None None AZM  A 264 (-4.1A) ZN  A 263 ( 3.2A) ZN  A 263 ( 3.2A) AZM  A 264 (-4.7A) AZM  A 264 ( 4.9A) AZM  A 264 (-3.4A) AZM  A 264 (-3.4A) AZM  A 264 (-3.5A) None	0.44A	34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3FW3_A_ETSA302_1 (CARBONIC ANHYDRASE 4)	3ml5	CARBONIC ANHYDRASE 7 (Homo sapiens)	7 / 12	HIS A   2 GLN A  92 VAL A 121 VAL A 143 LEU A 198 THR A 200 TRP A 209	None AZM  A 264 (-4.1A) AZM  A 264 (-4.7A) AZM  A 264 ( 4.9A) AZM  A 264 (-3.4A) AZM  A 264 (-3.5A) None	1.47A	34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3FW3_A_ETSA302_1 (CARBONIC ANHYDRASE 4)	3ml5	CARBONIC ANHYDRASE 7 (Homo sapiens)	6 / 12	HIS A  64 GLN A  67 HIS A  94 HIS A  96 THR A 199 THR A 200	None None ZN  A 263 ( 3.2A) ZN  A 263 ( 3.2A) AZM  A 264 (-3.4A) AZM  A 264 (-3.5A)	1.00A	34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3FW3_A_ETSA302_1 (CARBONIC ANHYDRASE 4)	3uyq	CARBONIC ANHYDRASE 3 (Homo sapiens)	11 / 12	ASN A  62 HIS A  64 GLN A  92 HIS A  94 HIS A  96 VAL A 121 ILE A 140 VAL A 142 THR A 198 THR A 199 TRP A 208	None None None ZN  A 261 (-3.3A) ZN  A 261 (-3.3A) None None None ZN  A 261 ( 4.4A) None None	0.68A	34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3FW3_A_ETSA302_1 (CARBONIC ANHYDRASE 4)	3uyq	CARBONIC ANHYDRASE 3 (Homo sapiens)	6 / 12	ASN A  62 HIS A  64 HIS A  96 ILE A 140 VAL A 121 THR A 199	None None ZN  A 261 (-3.3A) None None None	1.47A	34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3FW3_A_ETSA302_1 (CARBONIC ANHYDRASE 4)	3uyq	CARBONIC ANHYDRASE 3 (Homo sapiens)	6 / 12	GLN A  92 HIS A  94 HIS A  96 VAL A 121 ILE A 140 THR A 198	None ZN  A 261 (-3.3A) ZN  A 261 (-3.3A) None None ZN  A 261 ( 4.4A)	1.45A	34.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FW3_A_ETSA302_1 (CARBONIC ANHYDRASE 4)	4kkd	MANNAN-BINDING LECTIN SERINE PROTEASE 1 (Homo sapiens)	5 / 12	VAL A 516 ILE A 467 VAL A 469 LEU A 499 TRP A 480	None	0.90A	22.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3FW3_A_ETSA302_1 (CARBONIC ANHYDRASE 4)	4qk3	CARBONIC ANHYDRASE 2 (Homo sapiens)	10 / 12	ASN A  62 GLN A  92 HIS A  94 HIS A  96 VAL A 121 VAL A 143 LEU A 198 THR A 199 THR A 200 TRP A 209	None None ZN  A 301 (-3.2A) ZN  A 301 (-3.2A) None None None ZN  A 301 ( 4.4A) None None	0.43A	35.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3FW3_A_ETSA302_1 (CARBONIC ANHYDRASE 4)	4qk3	CARBONIC ANHYDRASE 2 (Homo sapiens)	6 / 12	ASN A  67 HIS A  96 VAL A 143 LEU A 198 THR A 199 THR A 200	None ZN  A 301 (-3.2A) None None ZN  A 301 ( 4.4A) None	0.96A	35.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3FW3_A_ETSA302_1 (CARBONIC ANHYDRASE 4)	5cjf	CARBONIC ANHYDRASE 14 (Homo sapiens)	11 / 12	ASN A  62 HIS A  64 GLN A  92 HIS A  94 HIS A  96 VAL A 121 VAL A 143 LEU A 198 THR A 199 THR A 200 TRP A 209	GOL  A 303 (-3.9A) None GOL  A 303 (-3.2A) ZN  A 301 (-3.2A) ZN  A 301 ( 3.2A) 520  A 302 ( 4.9A) 520  A 302 ( 4.9A) 520  A 302 (-3.6A) 520  A 302 (-3.4A) GOL  A 303 ( 3.5A) None	0.49A	35.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3FW3_A_ETSA302_1 (CARBONIC ANHYDRASE 4)	5cjf	CARBONIC ANHYDRASE 14 (Homo sapiens)	6 / 12	HIS A  64 GLN A  67 HIS A  94 HIS A  96 THR A 199 THR A 200	None GOL  A 303 (-3.4A) ZN  A 301 (-3.2A) ZN  A 301 ( 3.2A) 520  A 302 (-3.4A) GOL  A 303 ( 3.5A)	0.93A	35.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3FW3_A_ETSA302_1 (CARBONIC ANHYDRASE 4)	5cjf	CARBONIC ANHYDRASE 14 (Homo sapiens)	5 / 12	HIS A  96 VAL A 143 LEU A 198 THR A 199 THR A 200	ZN  A 301 ( 3.2A) 520  A 302 ( 4.9A) 520  A 302 (-3.6A) 520  A 302 (-3.4A) GOL  A 303 ( 3.5A)	0.97A	35.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3FW3_A_ETSA302_1 (CARBONIC ANHYDRASE 4)	5jn9	CARBONIC ANHYDRASE 4 (Homo sapiens)	11 / 12	ASN A  62 GLN A  92 HIS A  94 HIS A  96 VAL A 121 ILE A 141 VAL A 143 LEU A 198 THR A 199 THR A 200 TRP A 209	None EZL  A 302 (-4.3A) ZN  A 301 ( 3.3A) ZN  A 301 ( 3.3A) EZL  A 302 (-4.7A) None EZL  A 302 ( 4.7A) EZL  A 302 (-3.5A) EZL  A 302 (-3.4A) EZL  A 302 (-3.9A) None	0.35A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3FW3_A_ETSA302_1 (CARBONIC ANHYDRASE 4)	5jn9	CARBONIC ANHYDRASE 4 (Homo sapiens)	7 / 12	GLN A  92 HIS A  94 HIS A  96 VAL A 121 ILE A 141 LEU A 198 THR A 199	EZL  A 302 (-4.3A) ZN  A 301 ( 3.3A) ZN  A 301 ( 3.3A) EZL  A 302 (-4.7A) None EZL  A 302 (-3.5A) EZL  A 302 (-3.4A)	1.48A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3FW3_A_ETSA302_1 (CARBONIC ANHYDRASE 4)	5jn9	CARBONIC ANHYDRASE 4 (Homo sapiens)	6 / 12	HIS A  64 HIS A  96 LEU A 198 THR A 199 THR A 200 TRP A 209	None ZN  A 301 ( 3.3A) EZL  A 302 (-3.5A) EZL  A 302 (-3.4A) EZL  A 302 (-3.9A) None	0.75A	100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FW3_A_ETSA302_1 (CARBONIC ANHYDRASE 4)	6fe1	CARBONIC ANHYDRASE 9 (Homo sapiens)	11 / 12	ASN A  62 HIS A  64 GLN A  92 HIS A  94 HIS A  96 VAL A 121 VAL A 143 LEU A 198 THR A 199 THR A 200 TRP A 209	V14  A 302 (-3.4A) None V14  A 302 (-3.8A) ZN  A 301 ( 3.2A) ZN  A 301 ( 3.2A) V14  A 302 (-4.7A) None V14  A 302 (-3.6A) V14  A 302 (-3.2A) V14  A 302 (-3.5A) None	0.42A	16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FW3_A_ETSA302_1 (CARBONIC ANHYDRASE 4)	6fe1	CARBONIC ANHYDRASE 9 (Homo sapiens)	6 / 12	HIS A  64 HIS A  96 LEU A 198 THR A 199 THR A 200 TRP A 209	None ZN  A 301 ( 3.2A) V14  A 302 (-3.6A) V14  A 302 (-3.2A) V14  A 302 (-3.5A) None	1.27A	16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FW3_A_ETSA302_1 (CARBONIC ANHYDRASE 4)	6fe1	CARBONIC ANHYDRASE 9 (Homo sapiens)	5 / 12	HIS A  96 VAL A 143 LEU A 198 THR A 199 THR A 200	ZN  A 301 ( 3.2A) None V14  A 302 (-3.6A) V14  A 302 (-3.2A) V14  A 302 (-3.5A)	0.86A	16.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3FW3_B_ETSB303_1 (CARBONIC ANHYDRASE 4)	1jd0	CARBONIC ANHYDRASE XII (Homo sapiens)	11 / 12	ASN A  62 GLN A  92 HIS A  94 HIS A  96 HIS A 119 VAL A 121 VAL A 143 LEU A 198 THR A 199 THR A 200 TRP A 209	None AZM  A1400 (-3.2A) ZN  A 901 ( 3.2A) ZN  A 901 ( 3.2A) ZN  A 901 ( 3.1A) AZM  A1400 (-4.6A) AZM  A1400 ( 4.9A) AZM  A1400 (-3.9A) AZM  A1400 (-3.6A) AZM  A1400 (-3.3A) None	0.32A	35.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3FW3_B_ETSB303_1 (CARBONIC ANHYDRASE 4)	1jd0	CARBONIC ANHYDRASE XII (Homo sapiens)	6 / 12	GLN A  92 HIS A  94 HIS A  96 VAL A 121 LEU A 198 THR A 200	AZM  A1400 (-3.2A) ZN  A 901 ( 3.2A) ZN  A 901 ( 3.2A) AZM  A1400 (-4.6A) AZM  A1400 (-3.9A) AZM  A1400 (-3.3A)	1.43A	35.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3FW3_B_ETSB303_1 (CARBONIC ANHYDRASE 4)	1jd0	CARBONIC ANHYDRASE XII (Homo sapiens)	6 / 12	HIS A 119 HIS A  96 VAL A 143 LEU A 198 THR A 199 THR A 200	ZN  A 901 ( 3.1A) ZN  A 901 ( 3.2A) AZM  A1400 ( 4.9A) AZM  A1400 (-3.9A) AZM  A1400 (-3.6A) AZM  A1400 (-3.3A)	1.46A	35.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3FW3_B_ETSB303_1 (CARBONIC ANHYDRASE 4)	2it4	CARBONIC ANHYDRASE 1 (Homo sapiens)	8 / 12	GLN A  92 HIS A  94 HIS A  96 HIS A 119 VAL A 143 LEU A 198 THR A 199 TRP A 209	None ZN  A 561 ( 3.2A) ZN  A 561 ( 3.2A) ZN  A 561 ( 3.1A) PPF  A 500 (-4.9A) PPF  A 500 (-3.9A) PPF  A 500 (-3.6A) None	0.58A	31.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FW3_B_ETSB303_1 (CARBONIC ANHYDRASE 4)	2nz2	ARGININOSUCCINATE SYNTHASE (Homo sapiens)	5 / 12	GLN A 102 HIS A 116 VAL A 114 ILE A 139 VAL A 141	None None None NA  A 503 ( 4.7A) None	0.98A	21.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3FW3_B_ETSB303_1 (CARBONIC ANHYDRASE 4)	2w2j	CARBONIC ANHYDRASE-RELATED PROTEIN (Homo sapiens)	6 / 12	HIS A 118 HIS A 141 ILE A 163 LEU A 222 THR A 223 TRP A 233	CL  A 401 (-4.2A) CL  A 401 (-4.1A) None None CL  A 401 ( 4.8A) None	0.37A	31.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3FW3_B_ETSB303_1 (CARBONIC ANHYDRASE 4)	3da2	CARBONIC ANHYDRASE 13 (Homo sapiens)	8 / 12	HIS A  95 HIS A  97 HIS A 120 VAL A 122 VAL A 144 LEU A 199 THR A 200 TRP A 210	ZN  A 301 ( 3.6A) ZN  A 301 ( 3.5A) ZN  A 301 ( 3.2A) 4MD  A 401 ( 4.6A) 4MD  A 401 ( 4.4A) 4MD  A 401 (-4.2A) 4MD  A 401 (-3.2A) None	0.42A	33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3FW3_B_ETSB303_1 (CARBONIC ANHYDRASE 4)	3fe4	CARBONIC ANHYDRASE 6 (Homo sapiens)	10 / 12	ASN A  83 GLN A 109 HIS A 111 HIS A 113 HIS A 138 VAL A 140 VAL A 161 LEU A 219 THR A 220 TRP A 230	None None MG  A 901 (-3.4A) MG  A 901 (-3.4A) MG  A 901 (-3.2A) None None None None None	0.64A	32.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3FW3_B_ETSB303_1 (CARBONIC ANHYDRASE 4)	3ml5	CARBONIC ANHYDRASE 7 (Homo sapiens)	11 / 12	ASN A  62 GLN A  92 HIS A  94 HIS A  96 HIS A 119 VAL A 121 VAL A 143 LEU A 198 THR A 199 THR A 200 TRP A 209	None AZM  A 264 (-4.1A) ZN  A 263 ( 3.2A) ZN  A 263 ( 3.2A) ZN  A 263 ( 3.1A) AZM  A 264 (-4.7A) AZM  A 264 ( 4.9A) AZM  A 264 (-3.4A) AZM  A 264 (-3.4A) AZM  A 264 (-3.5A) None	0.30A	34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3FW3_B_ETSB303_1 (CARBONIC ANHYDRASE 4)	3ml5	CARBONIC ANHYDRASE 7 (Homo sapiens)	5 / 12	HIS A  96 VAL A 121 LEU A 198 THR A 199 THR A 200	ZN  A 263 ( 3.2A) AZM  A 264 (-4.7A) AZM  A 264 (-3.4A) AZM  A 264 (-3.4A) AZM  A 264 (-3.5A)	1.00A	34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3FW3_B_ETSB303_1 (CARBONIC ANHYDRASE 4)	3uyq	CARBONIC ANHYDRASE 3 (Homo sapiens)	11 / 12	ASN A  62 GLN A  92 HIS A  94 HIS A  96 HIS A 119 VAL A 121 ILE A 140 VAL A 142 THR A 198 THR A 199 TRP A 208	None None ZN  A 261 (-3.3A) ZN  A 261 (-3.3A) ZN  A 261 (-3.2A) None None None ZN  A 261 ( 4.4A) None None	0.56A	34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3FW3_B_ETSB303_1 (CARBONIC ANHYDRASE 4)	3uyq	CARBONIC ANHYDRASE 3 (Homo sapiens)	6 / 12	GLN A  92 HIS A  94 HIS A  96 VAL A 121 ILE A 140 THR A 199	None ZN  A 261 (-3.3A) ZN  A 261 (-3.3A) None None None	1.33A	34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3FW3_B_ETSB303_1 (CARBONIC ANHYDRASE 4)	3uyq	CARBONIC ANHYDRASE 3 (Homo sapiens)	6 / 12	HIS A  94 HIS A  96 VAL A 121 ILE A 140 VAL A 142 THR A 198	ZN  A 261 (-3.3A) ZN  A 261 (-3.3A) None None None ZN  A 261 ( 4.4A)	1.33A	34.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FW3_B_ETSB303_1 (CARBONIC ANHYDRASE 4)	4iw4	MANNAN-BINDING LECTIN SERINE PROTEASE 3 (Homo sapiens)	5 / 12	VAL E 497 ILE E 448 VAL E 450 LEU E 480 TRP E 461	None	1.03A	21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FW3_B_ETSB303_1 (CARBONIC ANHYDRASE 4)	4kkd	MANNAN-BINDING LECTIN SERINE PROTEASE 1 (Homo sapiens)	5 / 12	VAL A 516 ILE A 467 VAL A 469 LEU A 499 TRP A 480	None	0.85A	22.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3FW3_B_ETSB303_1 (CARBONIC ANHYDRASE 4)	4qk3	CARBONIC ANHYDRASE 2 (Homo sapiens)	11 / 12	ASN A  62 GLN A  92 HIS A  94 HIS A  96 HIS A 119 VAL A 121 VAL A 143 LEU A 198 THR A 199 THR A 200 TRP A 209	None None ZN  A 301 (-3.2A) ZN  A 301 (-3.2A) ZN  A 301 (-3.1A) None None None ZN  A 301 ( 4.4A) None None	0.33A	35.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3FW3_B_ETSB303_1 (CARBONIC ANHYDRASE 4)	4qk3	CARBONIC ANHYDRASE 2 (Homo sapiens)	6 / 12	ASN A  67 HIS A  96 VAL A 143 LEU A 198 THR A 199 THR A 200	None ZN  A 301 (-3.2A) None None ZN  A 301 ( 4.4A) None	0.97A	35.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3FW3_B_ETSB303_1 (CARBONIC ANHYDRASE 4)	5cjf	CARBONIC ANHYDRASE 14 (Homo sapiens)	11 / 12	ASN A  62 GLN A  92 HIS A  94 HIS A  96 HIS A 119 VAL A 121 VAL A 143 LEU A 198 THR A 199 THR A 200 TRP A 209	GOL  A 303 (-3.9A) GOL  A 303 (-3.2A) ZN  A 301 (-3.2A) ZN  A 301 ( 3.2A) ZN  A 301 ( 3.1A) 520  A 302 ( 4.9A) 520  A 302 ( 4.9A) 520  A 302 (-3.6A) 520  A 302 (-3.4A) GOL  A 303 ( 3.5A) None	0.35A	35.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3FW3_B_ETSB303_1 (CARBONIC ANHYDRASE 4)	5cjf	CARBONIC ANHYDRASE 14 (Homo sapiens)	5 / 12	HIS A  96 VAL A 143 LEU A 198 THR A 199 THR A 200	ZN  A 301 ( 3.2A) 520  A 302 ( 4.9A) 520  A 302 (-3.6A) 520  A 302 (-3.4A) GOL  A 303 ( 3.5A)	0.97A	35.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3FW3_B_ETSB303_1 (CARBONIC ANHYDRASE 4)	5jn9	CARBONIC ANHYDRASE 4 (Homo sapiens)	12 / 12	ASN A  62 GLN A  92 HIS A  94 HIS A  96 HIS A 119 VAL A 121 ILE A 141 VAL A 143 LEU A 198 THR A 199 THR A 200 TRP A 209	None EZL  A 302 (-4.3A) ZN  A 301 ( 3.3A) ZN  A 301 ( 3.3A) ZN  A 301 ( 3.2A) EZL  A 302 (-4.7A) None EZL  A 302 ( 4.7A) EZL  A 302 (-3.5A) EZL  A 302 (-3.4A) EZL  A 302 (-3.9A) None	0.27A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3FW3_B_ETSB303_1 (CARBONIC ANHYDRASE 4)	5jn9	CARBONIC ANHYDRASE 4 (Homo sapiens)	6 / 12	HIS A  94 HIS A  96 VAL A 143 ILE A 141 LEU A 198 THR A 200	ZN  A 301 ( 3.3A) ZN  A 301 ( 3.3A) EZL  A 302 ( 4.7A) None EZL  A 302 (-3.5A) EZL  A 302 (-3.9A)	1.34A	100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FW3_B_ETSB303_1 (CARBONIC ANHYDRASE 4)	6byn	WD REPEAT-CONTAINING PROTEIN 5 (Homo sapiens)	5 / 12	HIS W 170 ILE W 229 VAL W 220 LEU W 209 THR W 208	None	1.02A	15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FW3_B_ETSB303_1 (CARBONIC ANHYDRASE 4)	6fe1	CARBONIC ANHYDRASE 9 (Homo sapiens)	11 / 12	ASN A  62 GLN A  92 HIS A  94 HIS A  96 HIS A 119 VAL A 121 VAL A 143 LEU A 198 THR A 199 THR A 200 TRP A 209	V14  A 302 (-3.4A) V14  A 302 (-3.8A) ZN  A 301 ( 3.2A) ZN  A 301 ( 3.2A) ZN  A 301 ( 3.1A) V14  A 302 (-4.7A) None V14  A 302 (-3.6A) V14  A 302 (-3.2A) V14  A 302 (-3.5A) None	0.29A	16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FW3_B_ETSB303_1 (CARBONIC ANHYDRASE 4)	6fe1	CARBONIC ANHYDRASE 9 (Homo sapiens)	5 / 12	HIS A  96 VAL A 143 LEU A 198 THR A 199 THR A 200	ZN  A 301 ( 3.2A) None V14  A 302 (-3.6A) V14  A 302 (-3.2A) V14  A 302 (-3.5A)	0.84A	16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K13_A_ETSA304_1 (CARBONIC ANHYDRASE 2)	1fdw	17-BETA-HYDROXYSTERO ID DEHYDROGENASE (Homo sapiens)	5 / 12	VAL A   5 LEU A 244 LEU A  22 VAL A  32 LEU A  18	None	0.99A	20.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4K13_A_ETSA304_1 (CARBONIC ANHYDRASE 2)	1jd0	CARBONIC ANHYDRASE XII (Homo sapiens)	11 / 12	GLN A  92 HIS A  94 HIS A  96 HIS A 119 VAL A 121 LEU A 141 VAL A 143 LEU A 198 THR A 199 THR A 200 TRP A 209	AZM  A1400 (-3.2A) ZN  A 901 ( 3.2A) ZN  A 901 ( 3.2A) ZN  A 901 ( 3.1A) AZM  A1400 (-4.6A) None AZM  A1400 ( 4.9A) AZM  A1400 (-3.9A) AZM  A1400 (-3.6A) AZM  A1400 (-3.3A) None	0.34A	36.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4K13_A_ETSA304_1 (CARBONIC ANHYDRASE 2)	1jd0	CARBONIC ANHYDRASE XII (Homo sapiens)	7 / 12	GLN A  92 HIS A  94 HIS A  96 VAL A 121 LEU A 141 LEU A 198 THR A 200	AZM  A1400 (-3.2A) ZN  A 901 ( 3.2A) ZN  A 901 ( 3.2A) AZM  A1400 (-4.6A) None AZM  A1400 (-3.9A) AZM  A1400 (-3.3A)	1.41A	36.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4K13_A_ETSA304_1 (CARBONIC ANHYDRASE 2)	1jd0	CARBONIC ANHYDRASE XII (Homo sapiens)	6 / 12	HIS A  96 HIS A 119 LEU A 198 THR A 199 THR A 200 TRP A 209	ZN  A 901 ( 3.2A) ZN  A 901 ( 3.1A) AZM  A1400 (-3.9A) AZM  A1400 (-3.6A) AZM  A1400 (-3.3A) None	1.47A	36.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4K13_A_ETSA304_1 (CARBONIC ANHYDRASE 2)	1jd0	CARBONIC ANHYDRASE XII (Homo sapiens)	6 / 12	HIS A  96 VAL A 143 LEU A 141 LEU A 198 THR A 199 THR A 200	ZN  A 901 ( 3.2A) AZM  A1400 ( 4.9A) None AZM  A1400 (-3.9A) AZM  A1400 (-3.6A) AZM  A1400 (-3.3A)	1.28A	36.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4K13_A_ETSA304_1 (CARBONIC ANHYDRASE 2)	2it4	CARBONIC ANHYDRASE 1 (Homo sapiens)	10 / 12	GLN A  92 HIS A  94 HIS A  96 HIS A 119 LEU A 131 LEU A 141 VAL A 143 LEU A 198 THR A 199 TRP A 209	None ZN  A 561 ( 3.2A) ZN  A 561 ( 3.2A) ZN  A 561 ( 3.1A) None None PPF  A 500 (-4.9A) PPF  A 500 (-3.9A) PPF  A 500 (-3.6A) None	0.51A	60.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4K13_A_ETSA304_1 (CARBONIC ANHYDRASE 2)	2it4	CARBONIC ANHYDRASE 1 (Homo sapiens)	6 / 12	HIS A 119 HIS A 107 VAL A 143 LEU A 141 LEU A 198 THR A 199	ZN  A 561 ( 3.1A) None PPF  A 500 (-4.9A) None PPF  A 500 (-3.9A) PPF  A 500 (-3.6A)	1.49A	60.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4K13_A_ETSA304_1 (CARBONIC ANHYDRASE 2)	2w2j	CARBONIC ANHYDRASE-RELATED PROTEIN (Homo sapiens)	5 / 12	HIS A 118 HIS A 141 LEU A 222 THR A 223 TRP A 233	CL  A 401 (-4.2A) CL  A 401 (-4.1A) None CL  A 401 ( 4.8A) None	0.25A	38.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4K13_A_ETSA304_1 (CARBONIC ANHYDRASE 2)	3da2	CARBONIC ANHYDRASE 13 (Homo sapiens)	9 / 12	HIS A  95 HIS A  97 HIS A 120 VAL A 122 LEU A 142 VAL A 144 LEU A 199 THR A 200 TRP A 210	ZN  A 301 ( 3.6A) ZN  A 301 ( 3.5A) ZN  A 301 ( 3.2A) 4MD  A 401 ( 4.6A) None 4MD  A 401 ( 4.4A) 4MD  A 401 (-4.2A) 4MD  A 401 (-3.2A) None	0.43A	58.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4K13_A_ETSA304_1 (CARBONIC ANHYDRASE 2)	3fe4	CARBONIC ANHYDRASE 6 (Homo sapiens)	10 / 12	GLN A 109 HIS A 111 HIS A 113 HIS A 138 VAL A 140 LEU A 159 VAL A 161 LEU A 219 THR A 220 TRP A 230	None MG  A 901 (-3.4A) MG  A 901 (-3.4A) MG  A 901 (-3.2A) None None None None None None	0.64A	34.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4K13_A_ETSA304_1 (CARBONIC ANHYDRASE 2)	3fe4	CARBONIC ANHYDRASE 6 (Homo sapiens)	7 / 12	HIS A 111 HIS A 113 VAL A 140 LEU A 159 VAL A 161 LEU A 219 THR A 220	MG  A 901 (-3.4A) MG  A 901 (-3.4A) None None None None None	1.41A	34.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4K13_A_ETSA304_1 (CARBONIC ANHYDRASE 2)	3fe4	CARBONIC ANHYDRASE 6 (Homo sapiens)	5 / 12	LEU A 159 LEU A 219 THR A 220 THR A 221 TRP A 230	None	0.54A	34.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K13_A_ETSA304_1 (CARBONIC ANHYDRASE 2)	3jxf	RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE ZETA (Homo sapiens)	5 / 12	HIS A 129 LEU A 176 LEU A 235 THR A 236 TRP A 246	None	0.52A	28.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4K13_A_ETSA304_1 (CARBONIC ANHYDRASE 2)	3ml5	CARBONIC ANHYDRASE 7 (Homo sapiens)	11 / 12	GLN A  92 HIS A  94 HIS A  96 HIS A 119 VAL A 121 LEU A 141 VAL A 143 LEU A 198 THR A 199 THR A 200 TRP A 209	AZM  A 264 (-4.1A) ZN  A 263 ( 3.2A) ZN  A 263 ( 3.2A) ZN  A 263 ( 3.1A) AZM  A 264 (-4.7A) None AZM  A 264 ( 4.9A) AZM  A 264 (-3.4A) AZM  A 264 (-3.4A) AZM  A 264 (-3.5A) None	0.26A	56.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4K13_A_ETSA304_1 (CARBONIC ANHYDRASE 2)	3ml5	CARBONIC ANHYDRASE 7 (Homo sapiens)	6 / 12	HIS A  96 HIS A 119 LEU A 198 THR A 199 THR A 200 TRP A 209	ZN  A 263 ( 3.2A) ZN  A 263 ( 3.1A) AZM  A 264 (-3.4A) AZM  A 264 (-3.4A) AZM  A 264 (-3.5A) None	1.48A	56.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4K13_A_ETSA304_1 (CARBONIC ANHYDRASE 2)	3ml5	CARBONIC ANHYDRASE 7 (Homo sapiens)	6 / 12	HIS A  96 LEU A 141 VAL A 121 LEU A 198 THR A 199 THR A 200	ZN  A 263 ( 3.2A) None AZM  A 264 (-4.7A) AZM  A 264 (-3.4A) AZM  A 264 (-3.4A) AZM  A 264 (-3.5A)	1.26A	56.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4K13_A_ETSA304_1 (CARBONIC ANHYDRASE 2)	3uyq	CARBONIC ANHYDRASE 3 (Homo sapiens)	9 / 12	GLN A  92 HIS A  94 HIS A  96 HIS A 119 VAL A 121 VAL A 142 THR A 198 THR A 199 TRP A 208	None ZN  A 261 (-3.3A) ZN  A 261 (-3.3A) ZN  A 261 (-3.2A) None None ZN  A 261 ( 4.4A) None None	0.35A	57.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4K13_A_ETSA304_1 (CARBONIC ANHYDRASE 2)	4qk3	CARBONIC ANHYDRASE 2 (Homo sapiens)	11 / 12	GLN A  92 HIS A  94 HIS A  96 HIS A 119 VAL A 121 LEU A 141 VAL A 143 LEU A 198 THR A 199 THR A 200 TRP A 209	None ZN  A 301 (-3.2A) ZN  A 301 (-3.2A) ZN  A 301 (-3.1A) None None None None ZN  A 301 ( 4.4A) None None	0.10A	93.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4K13_A_ETSA304_1 (CARBONIC ANHYDRASE 2)	5cjf	CARBONIC ANHYDRASE 14 (Homo sapiens)	12 / 12	GLN A  92 HIS A  94 HIS A  96 HIS A 119 VAL A 121 LEU A 131 LEU A 141 VAL A 143 LEU A 198 THR A 199 THR A 200 TRP A 209	GOL  A 303 (-3.2A) ZN  A 301 (-3.2A) ZN  A 301 ( 3.2A) ZN  A 301 ( 3.1A) 520  A 302 ( 4.9A) 520  A 302 ( 4.8A) None 520  A 302 ( 4.9A) 520  A 302 (-3.6A) 520  A 302 (-3.4A) GOL  A 303 ( 3.5A) None	0.48A	38.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4K13_A_ETSA304_1 (CARBONIC ANHYDRASE 2)	5cjf	CARBONIC ANHYDRASE 14 (Homo sapiens)	7 / 12	GLN A  92 HIS A  94 HIS A  96 VAL A 121 LEU A 141 LEU A 198 THR A 200	GOL  A 303 (-3.2A) ZN  A 301 (-3.2A) ZN  A 301 ( 3.2A) 520  A 302 ( 4.9A) None 520  A 302 (-3.6A) GOL  A 303 ( 3.5A)	1.38A	38.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4K13_A_ETSA304_1 (CARBONIC ANHYDRASE 2)	5cjf	CARBONIC ANHYDRASE 14 (Homo sapiens)	6 / 12	HIS A  96 HIS A 119 LEU A 198 THR A 199 THR A 200 TRP A 209	ZN  A 301 ( 3.2A) ZN  A 301 ( 3.1A) 520  A 302 (-3.6A) 520  A 302 (-3.4A) GOL  A 303 ( 3.5A) None	1.46A	38.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4K13_A_ETSA304_1 (CARBONIC ANHYDRASE 2)	5cjf	CARBONIC ANHYDRASE 14 (Homo sapiens)	6 / 12	HIS A  96 VAL A 143 LEU A 141 LEU A 198 THR A 199 THR A 200	ZN  A 301 ( 3.2A) 520  A 302 ( 4.9A) None 520  A 302 (-3.6A) 520  A 302 (-3.4A) GOL  A 303 ( 3.5A)	1.31A	38.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4K13_A_ETSA304_1 (CARBONIC ANHYDRASE 2)	5cjf	CARBONIC ANHYDRASE 14 (Homo sapiens)	6 / 12	HIS A 119 HIS A 107 VAL A 143 LEU A 141 LEU A 198 THR A 199	ZN  A 301 ( 3.1A) None 520  A 302 ( 4.9A) None 520  A 302 (-3.6A) 520  A 302 (-3.4A)	1.48A	38.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K13_A_ETSA304_1 (CARBONIC ANHYDRASE 2)	5i85	SPHINGOMYELIN PHOSPHODIESTERASE (Homo sapiens)	6 / 12	VAL A 273 LEU A 264 LEU A 307 VAL A 312 THR A 300 TRP A 352	None	1.26A	17.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4K13_A_ETSA304_1 (CARBONIC ANHYDRASE 2)	5jn9	CARBONIC ANHYDRASE 4 (Homo sapiens)	10 / 12	GLN A  92 HIS A  94 HIS A  96 HIS A 119 VAL A 121 VAL A 143 LEU A 198 THR A 199 THR A 200 TRP A 209	EZL  A 302 (-4.3A) ZN  A 301 ( 3.3A) ZN  A 301 ( 3.3A) ZN  A 301 ( 3.2A) EZL  A 302 (-4.7A) EZL  A 302 ( 4.7A) EZL  A 302 (-3.5A) EZL  A 302 (-3.4A) EZL  A 302 (-3.9A) None	0.27A	36.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K13_A_ETSA304_1 (CARBONIC ANHYDRASE 2)	5zqz	TRIFUNCTIONAL ENZYME SUBUNIT ALPHA, MITOCHONDRIAL (Homo sapiens)	6 / 12	HIS A 498 LEU A 587 VAL A 591 LEU A 551 THR A 548 THR A 547	None	1.28A	17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K13_A_ETSA304_1 (CARBONIC ANHYDRASE 2)	6fe1	CARBONIC ANHYDRASE 9 (Homo sapiens)	11 / 12	GLN A  92 HIS A  94 HIS A  96 HIS A 119 VAL A 121 LEU A 141 VAL A 143 LEU A 198 THR A 199 THR A 200 TRP A 209	V14  A 302 (-3.8A) ZN  A 301 ( 3.2A) ZN  A 301 ( 3.2A) ZN  A 301 ( 3.1A) V14  A 302 (-4.7A) None None V14  A 302 (-3.6A) V14  A 302 (-3.2A) V14  A 302 (-3.5A) None	0.41A	15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K13_A_ETSA304_1 (CARBONIC ANHYDRASE 2)	6fe1	CARBONIC ANHYDRASE 9 (Homo sapiens)	5 / 12	HIS A  96 VAL A 143 LEU A 198 THR A 199 THR A 200	ZN  A 301 ( 3.2A) None V14  A 302 (-3.6A) V14  A 302 (-3.2A) V14  A 302 (-3.5A)	0.87A	15.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2U_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	1jd0	CARBONIC ANHYDRASE XII (Homo sapiens)	11 / 12	TRP A   5 HIS A  64 GLN A  92 HIS A  94 HIS A  96 VAL A 121 VAL A 143 LEU A 198 THR A 199 THR A 200 TRP A 209	None None AZM  A1400 (-3.2A) ZN  A 901 ( 3.2A) ZN  A 901 ( 3.2A) AZM  A1400 (-4.6A) AZM  A1400 ( 4.9A) AZM  A1400 (-3.9A) AZM  A1400 (-3.6A) AZM  A1400 (-3.3A) None	0.39A	36.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2U_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	1jd0	CARBONIC ANHYDRASE XII (Homo sapiens)	7 / 12	TRP A   5 HIS A  64 HIS A  96 VAL A 143 LEU A 198 THR A 199 THR A 200	None None ZN  A 901 ( 3.2A) AZM  A1400 ( 4.9A) AZM  A1400 (-3.9A) AZM  A1400 (-3.6A) AZM  A1400 (-3.3A)	1.16A	36.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2U_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	1jd0	CARBONIC ANHYDRASE XII (Homo sapiens)	8 / 12	TRP A  16 HIS A  94 HIS A  96 VAL A 121 VAL A 143 LEU A 198 THR A 200 TRP A 209	None ZN  A 901 ( 3.2A) ZN  A 901 ( 3.2A) AZM  A1400 (-4.6A) AZM  A1400 ( 4.9A) AZM  A1400 (-3.9A) AZM  A1400 (-3.3A) None	1.39A	36.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2U_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	2it4	CARBONIC ANHYDRASE 1 (Homo sapiens)	8 / 12	TRP A   5 GLN A  92 HIS A  94 HIS A  96 VAL A 143 LEU A 198 THR A 199 TRP A 209	None None ZN  A 561 ( 3.2A) ZN  A 561 ( 3.2A) PPF  A 500 (-4.9A) PPF  A 500 (-3.9A) PPF  A 500 (-3.6A) None	0.51A	60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2U_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	2it4	CARBONIC ANHYDRASE 1 (Homo sapiens)	7 / 12	TRP A  16 HIS A  94 HIS A  96 VAL A 143 LEU A 198 THR A 199 TRP A 209	None ZN  A 561 ( 3.2A) ZN  A 561 ( 3.2A) PPF  A 500 (-4.9A) PPF  A 500 (-3.9A) PPF  A 500 (-3.6A) None	1.35A	60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2U_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	2w2j	CARBONIC ANHYDRASE-RELATED PROTEIN (Homo sapiens)	6 / 12	TRP A  29 HIS A  87 HIS A 118 LEU A 222 THR A 223 TRP A 233	None None CL  A 401 (-4.2A) None CL  A 401 ( 4.8A) None	0.38A	38.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2U_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	3da2	CARBONIC ANHYDRASE 13 (Homo sapiens)	7 / 12	TRP A   6 HIS A  65 GLN A  93 HIS A  95 HIS A  97 LEU A 199 THR A 200	None None 4MD  A 401 (-3.1A) ZN  A 301 ( 3.6A) ZN  A 301 ( 3.5A) 4MD  A 401 (-4.2A) 4MD  A 401 (-3.2A)	0.87A	59.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2U_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	3da2	CARBONIC ANHYDRASE 13 (Homo sapiens)	7 / 12	TRP A   6 HIS A  65 GLN A  93 HIS A  97 PHE A 132 LEU A 199 THR A 200	None None 4MD  A 401 (-3.1A) ZN  A 301 ( 3.5A) 4MD  A 401 (-4.6A) 4MD  A 401 (-4.2A) 4MD  A 401 (-3.2A)	0.86A	59.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2U_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	3da2	CARBONIC ANHYDRASE 13 (Homo sapiens)	9 / 12	TRP A   6 HIS A  65 HIS A  95 HIS A  97 VAL A 122 VAL A 144 LEU A 199 THR A 200 TRP A 210	None None ZN  A 301 ( 3.6A) ZN  A 301 ( 3.5A) 4MD  A 401 ( 4.6A) 4MD  A 401 ( 4.4A) 4MD  A 401 (-4.2A) 4MD  A 401 (-3.2A) None	0.44A	59.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2U_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	3da2	CARBONIC ANHYDRASE 13 (Homo sapiens)	9 / 12	TRP A   6 HIS A  65 HIS A  97 VAL A 122 PHE A 132 VAL A 144 LEU A 199 THR A 200 TRP A 210	None None ZN  A 301 ( 3.5A) 4MD  A 401 ( 4.6A) 4MD  A 401 (-4.6A) 4MD  A 401 ( 4.4A) 4MD  A 401 (-4.2A) 4MD  A 401 (-3.2A) None	0.32A	59.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2U_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	3da2	CARBONIC ANHYDRASE 13 (Homo sapiens)	7 / 12	TRP A  17 HIS A  97 VAL A 122 VAL A 144 LEU A 199 THR A 200 TRP A 210	None ZN  A 301 ( 3.5A) 4MD  A 401 ( 4.6A) 4MD  A 401 ( 4.4A) 4MD  A 401 (-4.2A) 4MD  A 401 (-3.2A) None	1.40A	59.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2U_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	3fe4	CARBONIC ANHYDRASE 6 (Homo sapiens)	9 / 12	HIS A  85 GLN A 109 HIS A 111 HIS A 113 VAL A 140 VAL A 161 LEU A 219 THR A 220 TRP A 230	None None MG  A 901 (-3.4A) MG  A 901 (-3.4A) None None None None None	0.75A	34.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2U_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	3ml5	CARBONIC ANHYDRASE 7 (Homo sapiens)	6 / 12	GLN A  67 HIS A  96 VAL A 121 LEU A 198 THR A 199 THR A 200	None ZN  A 263 ( 3.2A) AZM  A 264 (-4.7A) AZM  A 264 (-3.4A) AZM  A 264 (-3.4A) AZM  A 264 (-3.5A)	1.23A	56.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2U_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	3ml5	CARBONIC ANHYDRASE 7 (Homo sapiens)	7 / 12	GLN A  92 HIS A  94 HIS A  96 VAL A 121 PHE A 131 LEU A 198 THR A 199	AZM  A 264 (-4.1A) ZN  A 263 ( 3.2A) ZN  A 263 ( 3.2A) AZM  A 264 (-4.7A) AZM  A 264 (-4.4A) AZM  A 264 (-3.4A) AZM  A 264 (-3.4A)	1.38A	56.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2U_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	3ml5	CARBONIC ANHYDRASE 7 (Homo sapiens)	8 / 12	HIS A   2 GLN A  92 VAL A 121 VAL A 143 LEU A 198 THR A 199 THR A 200 TRP A 209	None AZM  A 264 (-4.1A) AZM  A 264 (-4.7A) AZM  A 264 ( 4.9A) AZM  A 264 (-3.4A) AZM  A 264 (-3.4A) AZM  A 264 (-3.5A) None	1.21A	56.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2U_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	3ml5	CARBONIC ANHYDRASE 7 (Homo sapiens)	7 / 12	TRP A   5 GLN A  67 HIS A  94 HIS A  96 LEU A 198 THR A 199 THR A 200	None None ZN  A 263 ( 3.2A) ZN  A 263 ( 3.2A) AZM  A 264 (-3.4A) AZM  A 264 (-3.4A) AZM  A 264 (-3.5A)	1.13A	56.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2U_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	3ml5	CARBONIC ANHYDRASE 7 (Homo sapiens)	12 / 12	TRP A   5 HIS A  64 GLN A  92 HIS A  94 HIS A  96 VAL A 121 PHE A 131 VAL A 143 LEU A 198 THR A 199 THR A 200 TRP A 209	None None AZM  A 264 (-4.1A) ZN  A 263 ( 3.2A) ZN  A 263 ( 3.2A) AZM  A 264 (-4.7A) AZM  A 264 (-4.4A) AZM  A 264 ( 4.9A) AZM  A 264 (-3.4A) AZM  A 264 (-3.4A) AZM  A 264 (-3.5A) None	0.42A	56.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2U_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	3ml5	CARBONIC ANHYDRASE 7 (Homo sapiens)	7 / 12	TRP A   5 HIS A  64 HIS A  94 LEU A 198 THR A 199 THR A 200 TRP A 209	None None ZN  A 263 ( 3.2A) AZM  A 264 (-3.4A) AZM  A 264 (-3.4A) AZM  A 264 (-3.5A) None	1.37A	56.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2U_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	3ml5	CARBONIC ANHYDRASE 7 (Homo sapiens)	6 / 12	TRP A   5 HIS A  64 HIS A  96 VAL A 143 LEU A 198 THR A 200	None None ZN  A 263 ( 3.2A) AZM  A 264 ( 4.9A) AZM  A 264 (-3.4A) AZM  A 264 (-3.5A)	1.13A	56.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2U_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	3ml5	CARBONIC ANHYDRASE 7 (Homo sapiens)	8 / 12	TRP A  16 HIS A  94 HIS A  96 VAL A 121 VAL A 143 LEU A 198 THR A 200 TRP A 209	None ZN  A 263 ( 3.2A) ZN  A 263 ( 3.2A) AZM  A 264 (-4.7A) AZM  A 264 ( 4.9A) AZM  A 264 (-3.4A) AZM  A 264 (-3.5A) None	1.39A	56.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2U_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	3uyq	CARBONIC ANHYDRASE 3 (Homo sapiens)	7 / 12	GLN A  92 HIS A  94 HIS A  96 VAL A 121 PHE A 130 VAL A 142 THR A 198	None ZN  A 261 (-3.3A) ZN  A 261 (-3.3A) None None None ZN  A 261 ( 4.4A)	1.22A	58.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2U_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	3uyq	CARBONIC ANHYDRASE 3 (Homo sapiens)	11 / 12	TRP A   5 HIS A  64 GLN A  92 HIS A  94 HIS A  96 VAL A 121 PHE A 130 VAL A 142 THR A 198 THR A 199 TRP A 208	None None None ZN  A 261 (-3.3A) ZN  A 261 (-3.3A) None None None ZN  A 261 ( 4.4A) None None	0.47A	58.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2U_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	3uyq	CARBONIC ANHYDRASE 3 (Homo sapiens)	7 / 12	TRP A  16 HIS A  94 HIS A  96 VAL A 121 VAL A 142 THR A 199 TRP A 208	None ZN  A 261 (-3.3A) ZN  A 261 (-3.3A) None None None None	1.43A	58.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2U_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	4qk3	CARBONIC ANHYDRASE 2 (Homo sapiens)	7 / 12	GLN A  92 HIS A  94 HIS A  96 VAL A 121 PHE A 131 LEU A 198 THR A 199	None ZN  A 301 (-3.2A) ZN  A 301 (-3.2A) None None None ZN  A 301 ( 4.4A)	1.39A	95.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2U_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	4qk3	CARBONIC ANHYDRASE 2 (Homo sapiens)	11 / 12	TRP A   5 GLN A  92 HIS A  94 HIS A  96 VAL A 121 PHE A 131 VAL A 143 LEU A 198 THR A 199 THR A 200 TRP A 209	None None ZN  A 301 (-3.2A) ZN  A 301 (-3.2A) None None None None ZN  A 301 ( 4.4A) None None	0.29A	95.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2U_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	4qk3	CARBONIC ANHYDRASE 2 (Homo sapiens)	6 / 12	TRP A   5 HIS A  96 VAL A 121 LEU A 198 THR A 199 THR A 200	None ZN  A 301 (-3.2A) None None ZN  A 301 ( 4.4A) None	1.08A	95.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2U_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	5cjf	CARBONIC ANHYDRASE 14 (Homo sapiens)	7 / 12	TRP A   5 GLN A  67 HIS A  94 HIS A  96 LEU A 198 THR A 199 THR A 200	None GOL  A 303 (-3.4A) ZN  A 301 (-3.2A) ZN  A 301 ( 3.2A) 520  A 302 (-3.6A) 520  A 302 (-3.4A) GOL  A 303 ( 3.5A)	1.14A	37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2U_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	5cjf	CARBONIC ANHYDRASE 14 (Homo sapiens)	7 / 12	TRP A   5 GLN A  67 HIS A  96 VAL A 121 LEU A 198 THR A 199 THR A 200	None GOL  A 303 (-3.4A) ZN  A 301 ( 3.2A) 520  A 302 ( 4.9A) 520  A 302 (-3.6A) 520  A 302 (-3.4A) GOL  A 303 ( 3.5A)	1.35A	37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2U_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	5cjf	CARBONIC ANHYDRASE 14 (Homo sapiens)	11 / 12	TRP A   5 HIS A  64 GLN A  92 HIS A  94 HIS A  96 VAL A 121 VAL A 143 LEU A 198 THR A 199 THR A 200 TRP A 209	None None GOL  A 303 (-3.2A) ZN  A 301 (-3.2A) ZN  A 301 ( 3.2A) 520  A 302 ( 4.9A) 520  A 302 ( 4.9A) 520  A 302 (-3.6A) 520  A 302 (-3.4A) GOL  A 303 ( 3.5A) None	0.29A	37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2U_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	5cjf	CARBONIC ANHYDRASE 14 (Homo sapiens)	7 / 12	TRP A   5 HIS A  64 HIS A  96 VAL A 121 LEU A 198 THR A 199 THR A 200	None None ZN  A 301 ( 3.2A) 520  A 302 ( 4.9A) 520  A 302 (-3.6A) 520  A 302 (-3.4A) GOL  A 303 ( 3.5A)	1.22A	37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2U_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	5cjf	CARBONIC ANHYDRASE 14 (Homo sapiens)	9 / 12	TRP A  16 HIS A  94 HIS A  96 VAL A 121 VAL A 143 LEU A 198 THR A 199 THR A 200 TRP A 209	None ZN  A 301 (-3.2A) ZN  A 301 ( 3.2A) 520  A 302 ( 4.9A) 520  A 302 ( 4.9A) 520  A 302 (-3.6A) 520  A 302 (-3.4A) GOL  A 303 ( 3.5A) None	1.36A	37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2U_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	5jn9	CARBONIC ANHYDRASE 4 (Homo sapiens)	10 / 12	TRP A   5 GLN A  92 HIS A  94 HIS A  96 VAL A 121 VAL A 143 LEU A 198 THR A 199 THR A 200 TRP A 209	None EZL  A 302 (-4.3A) ZN  A 301 ( 3.3A) ZN  A 301 ( 3.3A) EZL  A 302 (-4.7A) EZL  A 302 ( 4.7A) EZL  A 302 (-3.5A) EZL  A 302 (-3.4A) EZL  A 302 (-3.9A) None	0.37A	35.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2U_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	5jn9	CARBONIC ANHYDRASE 4 (Homo sapiens)	6 / 12	TRP A   5 HIS A  64 HIS A  96 LEU A 198 THR A 199 THR A 200	None None ZN  A 301 ( 3.3A) EZL  A 302 (-3.5A) EZL  A 302 (-3.4A) EZL  A 302 (-3.9A)	1.05A	35.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2U_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	5jn9	CARBONIC ANHYDRASE 4 (Homo sapiens)	9 / 12	TRP A  16 HIS A  94 HIS A  96 VAL A 121 VAL A 143 LEU A 198 THR A 199 THR A 200 TRP A 209	None ZN  A 301 ( 3.3A) ZN  A 301 ( 3.3A) EZL  A 302 (-4.7A) EZL  A 302 ( 4.7A) EZL  A 302 (-3.5A) EZL  A 302 (-3.4A) EZL  A 302 (-3.9A) None	1.49A	35.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4M2U_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	6fe1	CARBONIC ANHYDRASE 9 (Homo sapiens)	11 / 12	TRP A   5 HIS A  64 GLN A  92 HIS A  94 HIS A  96 VAL A 121 VAL A 143 LEU A 198 THR A 199 THR A 200 TRP A 209	None None V14  A 302 (-3.8A) ZN  A 301 ( 3.2A) ZN  A 301 ( 3.2A) V14  A 302 (-4.7A) None V14  A 302 (-3.6A) V14  A 302 (-3.2A) V14  A 302 (-3.5A) None	0.39A	15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4M2U_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	6fe1	CARBONIC ANHYDRASE 9 (Homo sapiens)	8 / 12	TRP A   5 HIS A  64 HIS A  94 HIS A  96 VAL A 143 LEU A 198 THR A 199 THR A 200	None None ZN  A 301 ( 3.2A) ZN  A 301 ( 3.2A) None V14  A 302 (-3.6A) V14  A 302 (-3.2A) V14  A 302 (-3.5A)	1.20A	15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4M2U_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	6fe1	CARBONIC ANHYDRASE 9 (Homo sapiens)	7 / 12	TRP A   5 HIS A  64 HIS A  96 LEU A 198 THR A 199 THR A 200 TRP A 209	None None ZN  A 301 ( 3.2A) V14  A 302 (-3.6A) V14  A 302 (-3.2A) V14  A 302 (-3.5A) None	1.23A	15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4M2U_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	6fe1	CARBONIC ANHYDRASE 9 (Homo sapiens)	8 / 12	TRP A  16 HIS A  94 HIS A  96 VAL A 121 VAL A 143 LEU A 198 THR A 200 TRP A 209	None ZN  A 301 ( 3.2A) ZN  A 301 ( 3.2A) V14  A 302 (-4.7A) None V14  A 302 (-3.6A) V14  A 302 (-3.5A) None	1.39A	15.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2W_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	1jd0	CARBONIC ANHYDRASE XII (Homo sapiens)	11 / 12	GLN A  92 HIS A  94 HIS A  96 HIS A 119 VAL A 121 LEU A 141 VAL A 143 LEU A 198 THR A 199 THR A 200 TRP A 209	AZM  A1400 (-3.2A) ZN  A 901 ( 3.2A) ZN  A 901 ( 3.2A) ZN  A 901 ( 3.1A) AZM  A1400 (-4.6A) None AZM  A1400 ( 4.9A) AZM  A1400 (-3.9A) AZM  A1400 (-3.6A) AZM  A1400 (-3.3A) None	0.33A	36.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2W_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	1jd0	CARBONIC ANHYDRASE XII (Homo sapiens)	7 / 12	GLN A  92 HIS A  94 HIS A  96 VAL A 121 LEU A 141 LEU A 198 THR A 200	AZM  A1400 (-3.2A) ZN  A 901 ( 3.2A) ZN  A 901 ( 3.2A) AZM  A1400 (-4.6A) None AZM  A1400 (-3.9A) AZM  A1400 (-3.3A)	1.43A	36.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2W_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	1jd0	CARBONIC ANHYDRASE XII (Homo sapiens)	6 / 12	HIS A  96 HIS A 119 LEU A 198 THR A 199 THR A 200 TRP A 209	ZN  A 901 ( 3.2A) ZN  A 901 ( 3.1A) AZM  A1400 (-3.9A) AZM  A1400 (-3.6A) AZM  A1400 (-3.3A) None	1.48A	36.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2W_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	2it4	CARBONIC ANHYDRASE 1 (Homo sapiens)	9 / 12	GLN A  92 HIS A  94 HIS A  96 HIS A 119 LEU A 141 VAL A 143 LEU A 198 THR A 199 TRP A 209	None ZN  A 561 ( 3.2A) ZN  A 561 ( 3.2A) ZN  A 561 ( 3.1A) None PPF  A 500 (-4.9A) PPF  A 500 (-3.9A) PPF  A 500 (-3.6A) None	0.51A	60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2W_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	2w2j	CARBONIC ANHYDRASE-RELATED PROTEIN (Homo sapiens)	5 / 12	HIS A 118 HIS A 141 LEU A 222 THR A 223 TRP A 233	CL  A 401 (-4.2A) CL  A 401 (-4.1A) None CL  A 401 ( 4.8A) None	0.25A	38.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2W_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	3da2	CARBONIC ANHYDRASE 13 (Homo sapiens)	6 / 12	GLN A  93 HIS A  95 HIS A  97 LEU A 142 LEU A 199 THR A 200	4MD  A 401 (-3.1A) ZN  A 301 ( 3.6A) ZN  A 301 ( 3.5A) None 4MD  A 401 (-4.2A) 4MD  A 401 (-3.2A)	0.91A	58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2W_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	3da2	CARBONIC ANHYDRASE 13 (Homo sapiens)	9 / 12	HIS A  95 HIS A  97 HIS A 120 VAL A 122 LEU A 142 VAL A 144 LEU A 199 THR A 200 TRP A 210	ZN  A 301 ( 3.6A) ZN  A 301 ( 3.5A) ZN  A 301 ( 3.2A) 4MD  A 401 ( 4.6A) None 4MD  A 401 ( 4.4A) 4MD  A 401 (-4.2A) 4MD  A 401 (-3.2A) None	0.44A	58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2W_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	3fe4	CARBONIC ANHYDRASE 6 (Homo sapiens)	10 / 12	GLN A 109 HIS A 111 HIS A 113 HIS A 138 VAL A 140 LEU A 159 VAL A 161 LEU A 219 THR A 220 TRP A 230	None MG  A 901 (-3.4A) MG  A 901 (-3.4A) MG  A 901 (-3.2A) None None None None None None	0.58A	34.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2W_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	3fe4	CARBONIC ANHYDRASE 6 (Homo sapiens)	7 / 12	HIS A 111 HIS A 113 VAL A 140 LEU A 159 VAL A 161 LEU A 219 THR A 220	MG  A 901 (-3.4A) MG  A 901 (-3.4A) None None None None None	1.37A	34.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2W_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	3fe4	CARBONIC ANHYDRASE 6 (Homo sapiens)	5 / 12	LEU A 159 LEU A 219 THR A 220 THR A 221 TRP A 230	None	0.54A	34.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4M2W_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	3jxf	RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE ZETA (Homo sapiens)	5 / 12	HIS A 129 LEU A 176 LEU A 235 THR A 236 TRP A 246	None	0.60A	28.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2W_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	3ml5	CARBONIC ANHYDRASE 7 (Homo sapiens)	6 / 12	GLN A  67 HIS A  96 VAL A 121 LEU A 198 THR A 199 THR A 200	None ZN  A 263 ( 3.2A) AZM  A 264 (-4.7A) AZM  A 264 (-3.4A) AZM  A 264 (-3.4A) AZM  A 264 (-3.5A)	1.20A	56.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2W_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	3ml5	CARBONIC ANHYDRASE 7 (Homo sapiens)	11 / 12	GLN A  92 HIS A  94 HIS A  96 HIS A 119 VAL A 121 LEU A 141 VAL A 143 LEU A 198 THR A 199 THR A 200 TRP A 209	AZM  A 264 (-4.1A) ZN  A 263 ( 3.2A) ZN  A 263 ( 3.2A) ZN  A 263 ( 3.1A) AZM  A 264 (-4.7A) None AZM  A 264 ( 4.9A) AZM  A 264 (-3.4A) AZM  A 264 (-3.4A) AZM  A 264 (-3.5A) None	0.32A	56.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2W_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	3ml5	CARBONIC ANHYDRASE 7 (Homo sapiens)	6 / 12	HIS A  96 LEU A 141 VAL A 121 LEU A 198 THR A 199 THR A 200	ZN  A 263 ( 3.2A) None AZM  A 264 (-4.7A) AZM  A 264 (-3.4A) AZM  A 264 (-3.4A) AZM  A 264 (-3.5A)	1.32A	56.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2W_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	3uyq	CARBONIC ANHYDRASE 3 (Homo sapiens)	9 / 12	GLN A  92 HIS A  94 HIS A  96 HIS A 119 VAL A 121 VAL A 142 THR A 198 THR A 199 TRP A 208	None ZN  A 261 (-3.3A) ZN  A 261 (-3.3A) ZN  A 261 (-3.2A) None None ZN  A 261 ( 4.4A) None None	0.36A	57.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2W_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	3uyq	CARBONIC ANHYDRASE 3 (Homo sapiens)	6 / 12	GLN A  92 HIS A  94 HIS A  96 VAL A 121 VAL A 142 THR A 198	None ZN  A 261 (-3.3A) ZN  A 261 (-3.3A) None None ZN  A 261 ( 4.4A)	1.24A	57.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2W_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	4qk3	CARBONIC ANHYDRASE 2 (Homo sapiens)	11 / 12	GLN A  92 HIS A  94 HIS A  96 HIS A 119 VAL A 121 LEU A 141 VAL A 143 LEU A 198 THR A 199 THR A 200 TRP A 209	None ZN  A 301 (-3.2A) ZN  A 301 (-3.2A) ZN  A 301 (-3.1A) None None None None ZN  A 301 ( 4.4A) None None	0.15A	93.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2W_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	4qk3	CARBONIC ANHYDRASE 2 (Homo sapiens)	7 / 12	GLN A  92 HIS A  94 HIS A  96 VAL A 121 LEU A 141 LEU A 198 THR A 199	None ZN  A 301 (-3.2A) ZN  A 301 (-3.2A) None None None ZN  A 301 ( 4.4A)	1.40A	93.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2W_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	5cjf	CARBONIC ANHYDRASE 14 (Homo sapiens)	5 / 12	GLN A  67 HIS A  96 LEU A 198 THR A 199 THR A 200	GOL  A 303 (-3.4A) ZN  A 301 ( 3.2A) 520  A 302 (-3.6A) 520  A 302 (-3.4A) GOL  A 303 ( 3.5A)	0.98A	38.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2W_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	5cjf	CARBONIC ANHYDRASE 14 (Homo sapiens)	11 / 12	GLN A  92 HIS A  94 HIS A  96 HIS A 119 VAL A 121 LEU A 141 VAL A 143 LEU A 198 THR A 199 THR A 200 TRP A 209	GOL  A 303 (-3.2A) ZN  A 301 (-3.2A) ZN  A 301 ( 3.2A) ZN  A 301 ( 3.1A) 520  A 302 ( 4.9A) None 520  A 302 ( 4.9A) 520  A 302 (-3.6A) 520  A 302 (-3.4A) GOL  A 303 ( 3.5A) None	0.18A	38.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2W_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	5cjf	CARBONIC ANHYDRASE 14 (Homo sapiens)	6 / 12	HIS A  96 VAL A 143 LEU A 141 LEU A 198 THR A 199 THR A 200	ZN  A 301 ( 3.2A) 520  A 302 ( 4.9A) None 520  A 302 (-3.6A) 520  A 302 (-3.4A) GOL  A 303 ( 3.5A)	1.25A	38.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2W_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	5cjf	CARBONIC ANHYDRASE 14 (Homo sapiens)	7 / 12	LEU A 131 HIS A  94 HIS A  96 VAL A 143 THR A 199 THR A 200 TRP A 209	520  A 302 ( 4.8A) ZN  A 301 (-3.2A) ZN  A 301 ( 3.2A) 520  A 302 ( 4.9A) 520  A 302 (-3.4A) GOL  A 303 ( 3.5A) None	0.95A	38.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M2W_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	5jn9	CARBONIC ANHYDRASE 4 (Homo sapiens)	10 / 12	GLN A  92 HIS A  94 HIS A  96 HIS A 119 VAL A 121 VAL A 143 LEU A 198 THR A 199 THR A 200 TRP A 209	EZL  A 302 (-4.3A) ZN  A 301 ( 3.3A) ZN  A 301 ( 3.3A) ZN  A 301 ( 3.2A) EZL  A 302 (-4.7A) EZL  A 302 ( 4.7A) EZL  A 302 (-3.5A) EZL  A 302 (-3.4A) EZL  A 302 (-3.9A) None	0.30A	36.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4M2W_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	5zqz	TRIFUNCTIONAL ENZYME SUBUNIT ALPHA, MITOCHONDRIAL (Homo sapiens)	6 / 12	HIS A 498 LEU A 587 VAL A 591 LEU A 551 THR A 548 THR A 547	None	1.27A	16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4M2W_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	6fe1	CARBONIC ANHYDRASE 9 (Homo sapiens)	6 / 12	HIS A  96 LEU A 141 VAL A 121 LEU A 198 THR A 199 THR A 200	ZN  A 301 ( 3.2A) None V14  A 302 (-4.7A) V14  A 302 (-3.6A) V14  A 302 (-3.2A) V14  A 302 (-3.5A)	1.32A	14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4M2W_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	6fe1	CARBONIC ANHYDRASE 9 (Homo sapiens)	12 / 12	LEU A  91 GLN A  92 HIS A  94 HIS A  96 HIS A 119 VAL A 121 LEU A 141 VAL A 143 LEU A 198 THR A 199 THR A 200 TRP A 209	None V14  A 302 (-3.8A) ZN  A 301 ( 3.2A) ZN  A 301 ( 3.2A) ZN  A 301 ( 3.1A) V14  A 302 (-4.7A) None None V14  A 302 (-3.6A) V14  A 302 (-3.2A) V14  A 302 (-3.5A) None	0.61A	14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BC9_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	1jd0	CARBONIC ANHYDRASE XII (Homo sapiens)	11 / 12	TRP A   5 ASN A  62 GLN A  92 HIS A  94 HIS A  96 VAL A 121 LEU A 198 THR A 199 THR A 200 PRO A 202 TRP A 209	None None AZM  A1400 (-3.2A) ZN  A 901 ( 3.2A) ZN  A 901 ( 3.2A) AZM  A1400 (-4.6A) AZM  A1400 (-3.9A) AZM  A1400 (-3.6A) AZM  A1400 (-3.3A) None None	0.51A	15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BC9_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	1jd0	CARBONIC ANHYDRASE XII (Homo sapiens)	8 / 12	TRP A  16 HIS A  94 HIS A  96 VAL A 121 LEU A 198 THR A 200 PRO A 202 TRP A 209	None ZN  A 901 ( 3.2A) ZN  A 901 ( 3.2A) AZM  A1400 (-4.6A) AZM  A1400 (-3.9A) AZM  A1400 (-3.3A) None None	1.49A	15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BC9_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	2it4	CARBONIC ANHYDRASE 1 (Homo sapiens)	8 / 12	TRP A   5 GLN A  92 HIS A  94 HIS A  96 LEU A 198 THR A 199 PRO A 202 TRP A 209	None None ZN  A 561 ( 3.2A) ZN  A 561 ( 3.2A) PPF  A 500 (-3.9A) PPF  A 500 (-3.6A) None None	0.49A	19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BC9_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	2it4	CARBONIC ANHYDRASE 1 (Homo sapiens)	6 / 12	TRP A   5 HIS A  96 VAL A 143 LEU A 198 THR A 199 PRO A 202	None ZN  A 561 ( 3.2A) PPF  A 500 (-4.9A) PPF  A 500 (-3.9A) PPF  A 500 (-3.6A) None	1.16A	19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BC9_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	2w2j	CARBONIC ANHYDRASE-RELATED PROTEIN (Homo sapiens)	6 / 12	TRP A  29 HIS A 118 LEU A 222 THR A 223 PRO A 226 TRP A 233	None CL  A 401 (-4.2A) None CL  A 401 ( 4.8A) None None	0.38A	22.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6BC9_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	3da2	CARBONIC ANHYDRASE 13 (Homo sapiens)	6 / 12	ASN A  68 HIS A  97 LEU A 199 THR A 200 PRO A 203 TRP A 210	None ZN  A 301 ( 3.5A) 4MD  A 401 (-4.2A) 4MD  A 401 (-3.2A) 4MD  A 401 ( 4.9A) None	1.13A	30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6BC9_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	3da2	CARBONIC ANHYDRASE 13 (Homo sapiens)	8 / 12	TRP A   6 GLN A  93 HIS A  95 HIS A  97 VAL A 122 LEU A 199 THR A 200 PRO A 203	None 4MD  A 401 (-3.1A) ZN  A 301 ( 3.6A) ZN  A 301 ( 3.5A) 4MD  A 401 ( 4.6A) 4MD  A 401 (-4.2A) 4MD  A 401 (-3.2A) 4MD  A 401 ( 4.9A)	0.85A	30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6BC9_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	3da2	CARBONIC ANHYDRASE 13 (Homo sapiens)	8 / 12	TRP A   6 GLN A  93 HIS A  97 VAL A 122 PHE A 132 LEU A 199 THR A 200 PRO A 203	None 4MD  A 401 (-3.1A) ZN  A 301 ( 3.5A) 4MD  A 401 ( 4.6A) 4MD  A 401 (-4.6A) 4MD  A 401 (-4.2A) 4MD  A 401 (-3.2A) 4MD  A 401 ( 4.9A)	0.83A	30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6BC9_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	3da2	CARBONIC ANHYDRASE 13 (Homo sapiens)	8 / 12	TRP A   6 HIS A  95 HIS A  97 VAL A 122 LEU A 199 THR A 200 PRO A 203 TRP A 210	None ZN  A 301 ( 3.6A) ZN  A 301 ( 3.5A) 4MD  A 401 ( 4.6A) 4MD  A 401 (-4.2A) 4MD  A 401 (-3.2A) 4MD  A 401 ( 4.9A) None	0.45A	30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6BC9_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	3da2	CARBONIC ANHYDRASE 13 (Homo sapiens)	8 / 12	TRP A   6 HIS A  97 VAL A 122 PHE A 132 LEU A 199 THR A 200 PRO A 203 TRP A 210	None ZN  A 301 ( 3.5A) 4MD  A 401 ( 4.6A) 4MD  A 401 (-4.6A) 4MD  A 401 (-4.2A) 4MD  A 401 (-3.2A) 4MD  A 401 ( 4.9A) None	0.33A	30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6BC9_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	3da2	CARBONIC ANHYDRASE 13 (Homo sapiens)	7 / 12	TRP A  17 HIS A  95 HIS A  97 VAL A 122 LEU A 199 THR A 200 TRP A 210	None ZN  A 301 ( 3.6A) ZN  A 301 ( 3.5A) 4MD  A 401 ( 4.6A) 4MD  A 401 (-4.2A) 4MD  A 401 (-3.2A) None	1.48A	30.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BC9_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	3fe4	CARBONIC ANHYDRASE 6 (Homo sapiens)	8 / 12	ASN A  83 GLN A 109 HIS A 111 HIS A 113 VAL A 140 LEU A 219 THR A 220 TRP A 230	None None MG  A 901 (-3.4A) MG  A 901 (-3.4A) None None None None	0.69A	16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BC9_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	3jxf	RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE ZETA (Homo sapiens)	6 / 12	TRP A  38 HIS A 129 LEU A 235 THR A 236 PRO A 239 TRP A 246	None	0.48A	12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BC9_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	3ml5	CARBONIC ANHYDRASE 7 (Homo sapiens)	7 / 12	GLN A  92 HIS A  94 HIS A  96 VAL A 121 PHE A 131 LEU A 198 THR A 199	AZM  A 264 (-4.1A) ZN  A 263 ( 3.2A) ZN  A 263 ( 3.2A) AZM  A 264 (-4.7A) AZM  A 264 (-4.4A) AZM  A 264 (-3.4A) AZM  A 264 (-3.4A)	1.38A	18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BC9_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	3ml5	CARBONIC ANHYDRASE 7 (Homo sapiens)	12 / 12	TRP A   5 ASN A  62 GLN A  92 HIS A  94 HIS A  96 VAL A 121 PHE A 131 LEU A 198 THR A 199 THR A 200 PRO A 202 TRP A 209	None None AZM  A 264 (-4.1A) ZN  A 263 ( 3.2A) ZN  A 263 ( 3.2A) AZM  A 264 (-4.7A) AZM  A 264 (-4.4A) AZM  A 264 (-3.4A) AZM  A 264 (-3.4A) AZM  A 264 (-3.5A) None None	0.48A	18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BC9_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	3ml5	CARBONIC ANHYDRASE 7 (Homo sapiens)	8 / 12	TRP A   5 GLN A  67 HIS A  94 HIS A  96 LEU A 198 THR A 199 THR A 200 PRO A 202	None None ZN  A 263 ( 3.2A) ZN  A 263 ( 3.2A) AZM  A 264 (-3.4A) AZM  A 264 (-3.4A) AZM  A 264 (-3.5A) None	1.10A	18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BC9_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	3ml5	CARBONIC ANHYDRASE 7 (Homo sapiens)	7 / 12	TRP A   5 HIS A  94 LEU A 198 THR A 199 THR A 200 PRO A 202 TRP A 209	None ZN  A 263 ( 3.2A) AZM  A 264 (-3.4A) AZM  A 264 (-3.4A) AZM  A 264 (-3.5A) None None	1.32A	18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BC9_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	3ml5	CARBONIC ANHYDRASE 7 (Homo sapiens)	6 / 12	TRP A   5 HIS A  96 VAL A 143 LEU A 198 THR A 200 PRO A 202	None ZN  A 263 ( 3.2A) AZM  A 264 ( 4.9A) AZM  A 264 (-3.4A) AZM  A 264 (-3.5A) None	1.02A	18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BC9_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	3ml5	CARBONIC ANHYDRASE 7 (Homo sapiens)	7 / 12	TRP A  16 HIS A  94 HIS A  96 VAL A 121 LEU A 198 THR A 200 TRP A 209	None ZN  A 263 ( 3.2A) ZN  A 263 ( 3.2A) AZM  A 264 (-4.7A) AZM  A 264 (-3.4A) AZM  A 264 (-3.5A) None	1.46A	18.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6BC9_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	3uyq	CARBONIC ANHYDRASE 3 (Homo sapiens)	6 / 12	GLN A  92 HIS A  94 HIS A  96 VAL A 121 PHE A 130 THR A 198	None ZN  A 261 (-3.3A) ZN  A 261 (-3.3A) None None ZN  A 261 ( 4.4A)	1.22A	32.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6BC9_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	3uyq	CARBONIC ANHYDRASE 3 (Homo sapiens)	10 / 12	TRP A   5 ASN A  62 GLN A  92 HIS A  94 HIS A  96 VAL A 121 PHE A 130 THR A 198 THR A 199 PRO A 201	None None None ZN  A 261 (-3.3A) ZN  A 261 (-3.3A) None None ZN  A 261 ( 4.4A) None None	0.56A	32.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6BC9_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	3uyq	CARBONIC ANHYDRASE 3 (Homo sapiens)	10 / 12	TRP A   5 ASN A  62 GLN A  92 HIS A  94 HIS A  96 VAL A 121 PHE A 130 THR A 198 THR A 199 TRP A 208	None None None ZN  A 261 (-3.3A) ZN  A 261 (-3.3A) None None ZN  A 261 ( 4.4A) None None	0.50A	32.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6BC9_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	4qk3	CARBONIC ANHYDRASE 2 (Homo sapiens)	6 / 12	ASN A  67 HIS A  96 LEU A 198 THR A 199 THR A 200 PRO A 202	None ZN  A 301 (-3.2A) None ZN  A 301 ( 4.4A) None None	1.05A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6BC9_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	4qk3	CARBONIC ANHYDRASE 2 (Homo sapiens)	6 / 12	ASN A  67 HIS A  96 VAL A 143 LEU A 198 THR A 200 PRO A 202	None ZN  A 301 (-3.2A) None None None None	1.03A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6BC9_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	4qk3	CARBONIC ANHYDRASE 2 (Homo sapiens)	7 / 12	GLN A  92 HIS A  94 HIS A  96 VAL A 121 PHE A 131 LEU A 198 THR A 199	None ZN  A 301 (-3.2A) ZN  A 301 (-3.2A) None None None ZN  A 301 ( 4.4A)	1.39A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6BC9_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	4qk3	CARBONIC ANHYDRASE 2 (Homo sapiens)	12 / 12	TRP A   5 ASN A  62 GLN A  92 HIS A  94 HIS A  96 VAL A 121 PHE A 131 LEU A 198 THR A 199 THR A 200 PRO A 202 TRP A 209	None None None ZN  A 301 (-3.2A) ZN  A 301 (-3.2A) None None None ZN  A 301 ( 4.4A) None None None	0.31A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6BC9_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	4qk3	CARBONIC ANHYDRASE 2 (Homo sapiens)	7 / 12	TRP A   5 HIS A  94 LEU A 198 THR A 199 THR A 200 PRO A 202 TRP A 209	None ZN  A 301 (-3.2A) None ZN  A 301 ( 4.4A) None None None	1.27A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6BC9_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	4qk3	CARBONIC ANHYDRASE 2 (Homo sapiens)	6 / 12	TRP A   5 HIS A  96 VAL A 143 LEU A 198 THR A 200 PRO A 202	None ZN  A 301 (-3.2A) None None None None	1.18A	100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BC9_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	5cjf	CARBONIC ANHYDRASE 14 (Homo sapiens)	11 / 12	TRP A   5 ASN A  62 GLN A  92 HIS A  94 HIS A  96 VAL A 121 LEU A 198 THR A 199 THR A 200 PRO A 202 TRP A 209	None GOL  A 303 (-3.9A) GOL  A 303 (-3.2A) ZN  A 301 (-3.2A) ZN  A 301 ( 3.2A) 520  A 302 ( 4.9A) 520  A 302 (-3.6A) 520  A 302 (-3.4A) GOL  A 303 ( 3.5A) None None	0.46A	24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BC9_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	5cjf	CARBONIC ANHYDRASE 14 (Homo sapiens)	7 / 12	TRP A   5 GLN A  67 HIS A  94 HIS A  96 LEU A 198 THR A 199 THR A 200	None GOL  A 303 (-3.4A) ZN  A 301 (-3.2A) ZN  A 301 ( 3.2A) 520  A 302 (-3.6A) 520  A 302 (-3.4A) GOL  A 303 ( 3.5A)	1.15A	24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BC9_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	5cjf	CARBONIC ANHYDRASE 14 (Homo sapiens)	6 / 12	TRP A   5 HIS A  94 LEU A 198 THR A 200 PRO A 202 TRP A 209	None ZN  A 301 (-3.2A) 520  A 302 (-3.6A) GOL  A 303 ( 3.5A) None None	1.30A	24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BC9_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	5cjf	CARBONIC ANHYDRASE 14 (Homo sapiens)	6 / 12	TRP A   5 HIS A  96 VAL A 143 LEU A 198 THR A 199 THR A 200	None ZN  A 301 ( 3.2A) 520  A 302 ( 4.9A) 520  A 302 (-3.6A) 520  A 302 (-3.4A) GOL  A 303 ( 3.5A)	1.08A	24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BC9_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	5cjf	CARBONIC ANHYDRASE 14 (Homo sapiens)	9 / 12	TRP A  16 HIS A  94 HIS A  96 VAL A 121 LEU A 198 THR A 199 THR A 200 PRO A 202 TRP A 209	None ZN  A 301 (-3.2A) ZN  A 301 ( 3.2A) 520  A 302 ( 4.9A) 520  A 302 (-3.6A) 520  A 302 (-3.4A) GOL  A 303 ( 3.5A) None None	1.44A	24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BC9_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	5jn9	CARBONIC ANHYDRASE 4 (Homo sapiens)	10 / 12	TRP A   5 ASN A  62 GLN A  92 HIS A  94 HIS A  96 VAL A 121 LEU A 198 THR A 199 THR A 200 TRP A 209	None None EZL  A 302 (-4.3A) ZN  A 301 ( 3.3A) ZN  A 301 ( 3.3A) EZL  A 302 (-4.7A) EZL  A 302 (-3.5A) EZL  A 302 (-3.4A) EZL  A 302 (-3.9A) None	0.42A	13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BC9_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	5jn9	CARBONIC ANHYDRASE 4 (Homo sapiens)	6 / 12	TRP A   5 HIS A  94 HIS A  96 VAL A 143 LEU A 198 THR A 200	None ZN  A 301 ( 3.3A) ZN  A 301 ( 3.3A) EZL  A 302 ( 4.7A) EZL  A 302 (-3.5A) EZL  A 302 (-3.9A)	1.34A	13.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6BC9_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	6fe1	CARBONIC ANHYDRASE 9 (Homo sapiens)	6 / 12	ASN A  62 HIS A  94 HIS A  96 THR A 199 PRO A 201 TRP A 209	V14  A 302 (-3.4A) ZN  A 301 ( 3.2A) ZN  A 301 ( 3.2A) V14  A 302 (-3.2A) None None	1.24A	33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6BC9_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	6fe1	CARBONIC ANHYDRASE 9 (Homo sapiens)	11 / 12	TRP A   5 ASN A  62 GLN A  92 HIS A  94 HIS A  96 VAL A 121 LEU A 198 THR A 199 THR A 200 PRO A 202 TRP A 209	None V14  A 302 (-3.4A) V14  A 302 (-3.8A) ZN  A 301 ( 3.2A) ZN  A 301 ( 3.2A) V14  A 302 (-4.7A) V14  A 302 (-3.6A) V14  A 302 (-3.2A) V14  A 302 (-3.5A) None None	0.51A	33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6BC9_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	6fe1	CARBONIC ANHYDRASE 9 (Homo sapiens)	8 / 12	TRP A   5 HIS A  94 HIS A  96 VAL A 143 LEU A 198 THR A 199 THR A 200 PRO A 202	None ZN  A 301 ( 3.2A) ZN  A 301 ( 3.2A) None V14  A 302 (-3.6A) V14  A 302 (-3.2A) V14  A 302 (-3.5A) None	1.10A	33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6BC9_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	6fe1	CARBONIC ANHYDRASE 9 (Homo sapiens)	6 / 12	TRP A   5 HIS A  94 LEU A 198 THR A 200 PRO A 202 TRP A 209	None ZN  A 301 ( 3.2A) V14  A 302 (-3.6A) V14  A 302 (-3.5A) None None	1.34A	33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6BC9_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	6fe1	CARBONIC ANHYDRASE 9 (Homo sapiens)	6 / 12	TRP A   5 HIS A  96 LEU A 198 THR A 199 THR A 200 TRP A 209	None ZN  A 301 ( 3.2A) V14  A 302 (-3.6A) V14  A 302 (-3.2A) V14  A 302 (-3.5A) None	1.21A	33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6BC9_A_ETSA302_1 (CARBONIC ANHYDRASE 2)	6fe1	CARBONIC ANHYDRASE 9 (Homo sapiens)	7 / 12	TRP A  16 HIS A  94 HIS A  96 VAL A 121 LEU A 198 THR A 200 TRP A 209	None ZN  A 301 ( 3.2A) ZN  A 301 ( 3.2A) V14  A 302 (-4.7A) V14  A 302 (-3.6A) V14  A 302 (-3.5A) None	1.46A	33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BC9_A_ETSA302_2 (CARBONIC ANHYDRASE 2)	1jd0	CARBONIC ANHYDRASE XII (Homo sapiens)	5 / 5	HIS A  64 GLU A 106 HIS A 119 LEU A 141 VAL A 143	None ZN  A 901 ( 4.5A) ZN  A 901 ( 3.1A) None AZM  A1400 ( 4.9A)	0.21A	15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BC9_A_ETSA302_2 (CARBONIC ANHYDRASE 2)	1s1g	POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY D MEMBER 3 (Homo sapiens)	4 / 5	HIS A 104 GLU A  89 LEU A  44 VAL A  46	ZN  A 152 (-3.3A) None None None	1.10A	15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BC9_A_ETSA302_2 (CARBONIC ANHYDRASE 2)	2it4	CARBONIC ANHYDRASE 1 (Homo sapiens)	4 / 5	GLU A 106 HIS A 119 LEU A 141 VAL A 143	ZN  A 561 ( 4.9A) ZN  A 561 ( 3.1A) None PPF  A 500 (-4.9A)	0.27A	19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BC9_A_ETSA302_2 (CARBONIC ANHYDRASE 2)	2lrr	DNA-BINDING PROTEIN SMUBP-2 (Homo sapiens)	4 / 5	HIS A 753 HIS A 769 LEU A 744 VAL A 782	None DGP  A 801 (-4.4A) None None	1.16A	25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BC9_A_ETSA302_2 (CARBONIC ANHYDRASE 2)	2o36	THIMET OLIGOPEPTIDASE (Homo sapiens)	4 / 5	HIS A  87 GLU A 474 HIS A 477 VAL A 501	None ZN  A 690 ( 4.1A) ZN  A 690 (-3.3A) None	1.14A	9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BC9_A_ETSA302_2 (CARBONIC ANHYDRASE 2)	2q9g	CYTOCHROME P450 46A1 (Homo sapiens)	4 / 5	HIS A 310 GLU A 305 HIS A 304 LEU A 204	HEM  A 505 ( 4.6A) None None None	1.01A	11.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6BC9_A_ETSA302_2 (CARBONIC ANHYDRASE 2)	3da2	CARBONIC ANHYDRASE 13 (Homo sapiens)	5 / 5	HIS A  65 GLU A 107 HIS A 120 LEU A 142 VAL A 144	None ZN  A 301 ( 4.9A) ZN  A 301 ( 3.2A) None 4MD  A 401 ( 4.4A)	0.29A	30.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BC9_A_ETSA302_2 (CARBONIC ANHYDRASE 2)	3fe4	CARBONIC ANHYDRASE 6 (Homo sapiens)	5 / 5	HIS A  85 GLU A 125 HIS A 138 LEU A 159 VAL A 161	None MG  A 901 ( 4.4A) MG  A 901 (-3.2A) None None	0.61A	16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BC9_A_ETSA302_2 (CARBONIC ANHYDRASE 2)	3ml5	CARBONIC ANHYDRASE 7 (Homo sapiens)	5 / 5	HIS A  64 GLU A 106 HIS A 119 LEU A 141 VAL A 143	None ZN  A 263 ( 4.6A) ZN  A 263 ( 3.1A) None AZM  A 264 ( 4.9A)	0.33A	18.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6BC9_A_ETSA302_2 (CARBONIC ANHYDRASE 2)	3uyq	CARBONIC ANHYDRASE 3 (Homo sapiens)	4 / 5	HIS A  64 GLU A 106 HIS A 119 VAL A 142	None ZN  A 261 ( 4.9A) ZN  A 261 (-3.2A) None	0.44A	32.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BC9_A_ETSA302_2 (CARBONIC ANHYDRASE 2)	3zi1	GLYOXALASE DOMAIN-CONTAINING PROTEIN 4 (Homo sapiens)	4 / 5	HIS A  34 GLU A  63 LEU A 232 VAL A 240	None None EDO  A1281 ( 3.9A) None	1.21A	14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BC9_A_ETSA302_2 (CARBONIC ANHYDRASE 2)	4lr2	BIS(5'-ADENOSYL)-TRI PHOSPHATASE ENPP4 (Homo sapiens)	4 / 5	HIS A  48 GLU A  55 HIS A 352 LEU A 226	None	1.13A	13.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6BC9_A_ETSA302_2 (CARBONIC ANHYDRASE 2)	4qk3	CARBONIC ANHYDRASE 2 (Homo sapiens)	4 / 5	GLU A 106 HIS A 119 LEU A 141 VAL A 143	ZN  A 301 ( 4.5A) ZN  A 301 (-3.1A) None None	0.10A	100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BC9_A_ETSA302_2 (CARBONIC ANHYDRASE 2)	4rfq	HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG (Homo sapiens)	4 / 5	GLU A 212 HIS A 214 LEU A 278 VAL A 277	None	0.90A	15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BC9_A_ETSA302_2 (CARBONIC ANHYDRASE 2)	4y7i	MYOTUBULARIN-RELATED PROTEIN 8 (Homo sapiens)	4 / 5	HIS A 379 GLU A 371 LEU A 450 VAL A 452	None	1.19A	12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BC9_A_ETSA302_2 (CARBONIC ANHYDRASE 2)	4yaq	PG9_N100FY FAB HEAVY CHAIN (Homo sapiens)	4 / 5	GLU H  95 HIS H  35 LEU H  45 VAL H  37	None	1.19A	13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BC9_A_ETSA302_2 (CARBONIC ANHYDRASE 2)	5cjf	CARBONIC ANHYDRASE 14 (Homo sapiens)	5 / 5	HIS A  64 GLU A 106 HIS A 119 LEU A 141 VAL A 143	None ZN  A 301 ( 4.6A) ZN  A 301 ( 3.1A) None 520  A 302 ( 4.9A)	0.18A	24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BC9_A_ETSA302_2 (CARBONIC ANHYDRASE 2)	5i2c	GATS-LIKE PROTEIN 3 (Homo sapiens)	4 / 5	GLU A 234 HIS A   8 LEU A  79 VAL A  78	None	1.12A	13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BC9_A_ETSA302_2 (CARBONIC ANHYDRASE 2)	5n2k	BRIAKINUMAB FAB HEAVY CHAIN (Homo sapiens)	4 / 5	HIS B 102 HIS B  35 LEU B  45 VAL B  37	None	1.06A	15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BC9_A_ETSA302_2 (CARBONIC ANHYDRASE 2)	5ons	DENSITY-REGULATED PROTEIN MALIGNANT T-CELL-AMPLIFIED SEQUENCE 1 (Homo sapiens)	4 / 5	HIS A 176 HIS A  86 LEU B  32 VAL B  31	None	1.05A	15.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6BC9_A_ETSA302_2 (CARBONIC ANHYDRASE 2)	6fe1	CARBONIC ANHYDRASE 9 (Homo sapiens)	5 / 5	HIS A  64 GLU A 106 HIS A 119 LEU A 141 VAL A 143	None V14  A 302 (-4.2A) ZN  A 301 ( 3.1A) None None	0.36A	33.33