POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		2vkp BTB/POZ
DOMAIN-CONTAINING
PROTEIN 6
(Homo
sapiens)		5 / 10LEU A  66
VAL A  93
TYR A  91
GLY A  33
TYR A  70
None
1.20A12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		3eay SENTRIN-SPECIFIC
PROTEASE 7
(Homo
sapiens)		5 / 10LYS A 681
VAL A 696
TYR A 685
GLY A 695
LEU A 974
None
1.37A20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		3uit INAD-LIKE PROTEIN,
MAGUK P55 SUBFAMILY
MEMBER 5, PROTEIN
LIN-7 HOMOLOG B
(Homo
sapiens;
Mus
musculus;
Rattus
norvegicus)		5 / 10LEU A 178
VAL A 185
VAL A 196
TYR A 253
GLY A 193
None
1.35A20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		4lec PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21A
(Homo
sapiens)		5 / 10LEU A 139
VAL A  79
VAL A  90
GLY A  80
LEU A 170
None
1.43A17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		4xb0 SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens)		5 / 10VAL A 527
VAL A 508
TYR A 510
TYR A 514
GLY A 517
None
1.38A17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		4xii CHOLINESTERASE
(Homo
sapiens)		5 / 10LEU A 403
VAL A 319
VAL A 321
TYR A 500
GLY A 320
None
1.35A21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens)		5 / 10LEU A 669
VAL A 614
VAL A 588
GLY A 608
LEU A 675
None
1.38A9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		1slm STROMELYSIN-1
(Homo
sapiens)		5 / 10LEU A  54
VAL A  80
TYR A  25
TYR A  24
LEU A 222
None
1.43A19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		1wfm SYNAPTOTAGMIN XIII
(Homo
sapiens)		5 / 10LEU A 111
VAL A  48
VAL A  30
TYR A  17
LEU A 130
None
1.38A13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		2l2o UPF0727 PROTEIN
C6ORF115
(Homo
sapiens)		5 / 10LEU A  50
VAL A  28
VAL A  74
TYR A  61
LEU A  10
None
1.41A10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		2ozu HISTONE
ACETYLTRANSFERASE
MYST3
(Homo
sapiens)		5 / 10LEU A 593
VAL A 610
VAL A 581
TYR A 589
GLY A 583
None
1.46A20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		2pid TYROSYL-TRNA
SYNTHETASE
(Homo
sapiens)		5 / 10LEU A 224
TYR A 177
GLY A 114
LEU A 119
TYR A 221
None
None
None
None
YSA  A 384 (-4.7A)
1.40A20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		2rr8 IQGAP1 PROTEIN
(Homo
sapiens)		5 / 10LEU A  72
VAL A 116
VAL A  76
TYR A  77
GLY A  75
None
1.29A16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		2y0m PROBABLE HISTONE
ACETYLTRANSFERASE
MYST1
(Homo
sapiens)		5 / 10LEU A 263
VAL A 280
VAL A 251
TYR A 259
GLY A 253
None
1.47A18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens)		5 / 10LEU A 452
VAL A 751
GLY A 750
LEU A 776
TYR A 448
None
1.16A19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		3keh GLUCOCEREBROSIDASE
(Homo
sapiens)		5 / 10LEU A 249
ASN A 188
GLY A 189
TRP A 209
LEU A 197
None
1.12A20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		3n9v TYPE II
INOSITOL-1,4,5-TRISP
HOSPHATE
5-PHOSPHATASE
(Homo
sapiens)		5 / 10LEU A 448
VAL A 482
TYR A 415
TRP A 444
LEU A 527
None
1.39A20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens)		5 / 10LEU A 401
VAL A 335
VAL A 367
GLY A 345
LEU A 105
None
None
None
ACJ  A 478 (-3.6A)
None
1.41A23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		3sei CASKIN-1
(Homo
sapiens)		5 / 10LEU A  21
ASN A  25
VAL A  49
GLY A  48
LEU A  19
None
1.12A14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		4bla MALTOSE-BINDING
PERIPLASMIC PROTEIN,
SUPPRESSOR OF FUSED
HOMOLOG
(Escherichia
coli;
Homo
sapiens)		5 / 10LEU A 712
VAL A 736
TYR A 727
GLY A 643
LEU A 650
None
1.39A22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		4eza RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP2
(Homo
sapiens)		5 / 10LEU A  92
VAL A  46
VAL A   4
TYR A   6
LEU A  89
None
1.33A13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		4hmy ADP-RIBOSYLATION
FACTOR 1
(Homo
sapiens)		5 / 10LEU C 107
VAL C  23
VAL C  92
GLY C  24
LEU C 111
None
1.26A15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		4o27 CALCIUM-BINDING
PROTEIN 39
(Homo
sapiens)		5 / 10LEU A 218
VAL A 277
TYR A 214
GLY A 234
LEU A 258
None
1.41A22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		5gk9 HISTONE
ACETYLTRANSFERASE
KAT7
(Homo
sapiens)		5 / 10LEU A 421
VAL A 438
VAL A 409
TYR A 417
GLY A 411
None
1.43A17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		5jem INTERFERON
REGULATORY FACTOR 3
(Homo
sapiens)		5 / 10LEU A 245
VAL A 348
VAL A 261
TYR A 210
LEU A 228
None
1.33A18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		5vn8 B12 FAB HEAVY CHAIN
(Homo
sapiens)		5 / 10VAL H  95
TYR H 100
TYR H 100
GLY H  96
TYR H  98
None
1.40A16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		6byn WDR5-BINDING
MONOBODY, MB(S4)
(Homo
sapiens)		5 / 10LEU M  62
VAL M  66
TYR M  68
TYR M  94
GLY M  65
None
1.29A10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		2p6n ATP-DEPENDENT RNA
HELICASE DDX41
(Homo
sapiens)		5 / 9LEU A 545
VAL A 559
VAL A 412
TYR A 414
LEU A 566
None
1.21A15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		4lec PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21A
(Homo
sapiens)		5 / 9LEU A 139
VAL A  79
VAL A  90
GLY A  80
LEU A 170
None
1.32A17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		4xb0 SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens)		5 / 9VAL A 527
VAL A 508
TYR A 510
TYR A 514
GLY A 517
None
1.35A17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		4xii CHOLINESTERASE
(Homo
sapiens)		5 / 9LEU A 403
VAL A 319
VAL A 321
TYR A 500
GLY A 320
None
1.28A21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		2vkp BTB/POZ
DOMAIN-CONTAINING
PROTEIN 6
(Homo
sapiens)		5 / 10LEU A  66
VAL A  93
TYR A  91
GLY A  33
TYR A  70
None
1.21A11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		3eay SENTRIN-SPECIFIC
PROTEASE 7
(Homo
sapiens)		5 / 10LYS A 681
VAL A 696
TYR A 685
GLY A 695
LEU A 974
None
1.38A18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		3uit INAD-LIKE PROTEIN,
MAGUK P55 SUBFAMILY
MEMBER 5, PROTEIN
LIN-7 HOMOLOG B
(Homo
sapiens;
Mus
musculus;
Rattus
norvegicus)		5 / 10LEU A 178
VAL A 185
VAL A 196
TYR A 253
GLY A 193
None
1.32A21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE
(Homo
sapiens)		5 / 10LEU B1597
VAL B1617
VAL B1632
GLY B1618
LEU B1590
None
1.42A15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		4lec PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21A
(Homo
sapiens)		5 / 10LEU A 139
VAL A  79
VAL A  90
GLY A  80
LEU A 170
None
1.42A17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		4xb0 SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens)		5 / 10VAL A 527
VAL A 508
TYR A 510
TYR A 514
GLY A 517
None
1.39A17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1
(Homo
sapiens)		5 / 11LEU A 176
VAL A 172
CYH A 166
GLY A 195
LEU A 181
None
1.42A18.90
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		3nvq SEMAPHORIN-7A
(Homo
sapiens)		5 / 11LEU A 427
VAL A 324
VAL A 336
GLY A 323
GLU A 441
None
1.04A21.26
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		5for PHOSPHOINOSITIDE
3-KINASE ADAPTER
PROTEIN 1
(Homo
sapiens)		5 / 11LEU A  24
VAL A  96
VAL A 131
TRP A  20
LEU A  67
None
None
I3C  A1141 (-4.3A)
1PE  A1140 (-3.3A)
None
1.43A11.98
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens)		5 / 11LEU A 669
VAL A 614
VAL A 588
GLY A 608
LEU A 675
None
1.34A9.89
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		2a4d UBIQUITIN-CONJUGATIN
G ENZYME E2 VARIANT
1
(Homo
sapiens)		5 / 9LEU A 141
LYS A 142
VAL A 167
GLY A 172
LEU A 198
None
1.42A13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		2hlw UBIQUITIN-CONJUGATIN
G ENZYME E2 VARIANT
1
(Homo
sapiens)		5 / 9LEU A  90
LYS A  91
VAL A 116
GLY A 121
LEU A 147
None
1.22A14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		2hlw UBIQUITIN-CONJUGATIN
G ENZYME E2 VARIANT
1
(Homo
sapiens)		5 / 9LEU A  90
VAL A 123
TYR A  88
GLY A 121
LEU A 147
None
1.44A14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		2jii SERINE/THREONINE-PRO
TEIN KINASE VRK3
MOLECULE: VACCINIA
RELATED KINASE 3
(Homo
sapiens)		5 / 9LEU A 381
LYS A 382
VAL A 283
LEU A 428
TYR A 385
None
1.47A20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		2rgn RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 25
(Homo
sapiens)		5 / 9LEU B 302
LYS B 303
VAL B 164
TYR B 298
LEU B 235
None
1.50A20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		3eay SENTRIN-SPECIFIC
PROTEASE 7
(Homo
sapiens)		5 / 9LYS A 681
VAL A 696
TYR A 685
GLY A 695
LEU A 974
None
1.36A20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		4piv FATTY ACID SYNTHASE
(Homo
sapiens)		5 / 9LEU A1228
LYS A1225
TYR A1270
GLY A1258
LEU A1252
None
1.44A23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		5aj1 SWI/SNF-RELATED
MATRIX-ASSOCIATED
ACTIN-DEPENDENT
REGULATOR OF
CHROMATIN SUBFAMILY
B MEMBER 1
(Homo
sapiens)		5 / 9LEU A  36
TYR A  47
GLY A  29
LEU A 100
TYR A  35
None
1.42A12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Homo
sapiens)		5 / 10LEU A 110
VAL A 156
VAL A 149
TRP A  75
LEU A  56
None
1.32A11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		2p6n ATP-DEPENDENT RNA
HELICASE DDX41
(Homo
sapiens)		5 / 10LEU A 545
VAL A 559
VAL A 412
TYR A 414
LEU A 566
None
1.27A19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		2vkp BTB/POZ
DOMAIN-CONTAINING
PROTEIN 6
(Homo
sapiens)		5 / 10LEU A  66
VAL A  93
TYR A  91
GLY A  33
TYR A  70
None
1.17A25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens)		5 / 10LEU A 452
VAL A 751
GLY A 750
LEU A 776
TYR A 448
None
1.11A15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		3l15 TRANSCRIPTIONAL
ENHANCER FACTOR
TEF-4
(Homo
sapiens)		5 / 10VAL A 252
VAL A 329
TYR A 327
TRP A 308
LEU A 306
None
1.49A17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens)		5 / 10LEU A 401
VAL A 335
VAL A 367
GLY A 345
LEU A 105
None
None
None
ACJ  A 478 (-3.6A)
None
1.35A9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		3uit INAD-LIKE PROTEIN,
MAGUK P55 SUBFAMILY
MEMBER 5, PROTEIN
LIN-7 HOMOLOG B
(Homo
sapiens;
Mus
musculus;
Rattus
norvegicus)		5 / 10LEU A 178
VAL A 185
VAL A 196
TYR A 253
GLY A 193
None
1.42A14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE
(Homo
sapiens)		5 / 10LEU B1597
VAL B1617
VAL B1632
GLY B1618
LEU B1590
None
1.42A4.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		4xb0 SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens)		5 / 10VAL A 527
VAL A 508
TYR A 510
TYR A 514
GLY A 517
None
1.42A16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		4xii CHOLINESTERASE
(Homo
sapiens)		5 / 10LEU A 403
VAL A 319
VAL A 321
TYR A 500
GLY A 320
None
1.28A10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Homo
sapiens)		5 / 10LEU A 110
VAL A 156
VAL A 149
TRP A  75
LEU A  56
None
1.33A11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		3eay SENTRIN-SPECIFIC
PROTEASE 7
(Homo
sapiens)		5 / 10LYS A 681
VAL A 696
TYR A 685
GLY A 695
LEU A 974
None
1.35A13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		3ii7 KELCH-LIKE PROTEIN 7
(Homo
sapiens)		5 / 10LEU A 546
VAL A 521
VAL A 498
GLY A 487
LEU A 542
None
1.45A15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		3l15 TRANSCRIPTIONAL
ENHANCER FACTOR
TEF-4
(Homo
sapiens)		5 / 10VAL A 252
VAL A 329
TYR A 327
TRP A 308
LEU A 306
None
1.47A17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens)		5 / 10LEU A 401
VAL A 335
VAL A 367
GLY A 345
LEU A 105
None
None
None
ACJ  A 478 (-3.6A)
None
1.30A9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		3uit INAD-LIKE PROTEIN,
MAGUK P55 SUBFAMILY
MEMBER 5, PROTEIN
LIN-7 HOMOLOG B
(Homo
sapiens;
Mus
musculus;
Rattus
norvegicus)		5 / 10LEU A 178
VAL A 185
VAL A 196
TYR A 253
GLY A 193
None
1.30A14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE
(Homo
sapiens)		5 / 10LEU B1597
VAL B1617
VAL B1632
GLY B1618
LEU B1590
None
1.33A4.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		4lec PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21A
(Homo
sapiens)		5 / 10LEU A 139
VAL A  79
VAL A  90
GLY A  80
LEU A 170
None
1.49A13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6apj ALPHA-N-ACETYLGALACT
OSAMINIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 2
(Homo
sapiens)		5 / 10LEU A 371
VAL A 153
TYR A 372
TYR A 323
GLY A 155
None
1.46A16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens)		5 / 10LEU A 669
VAL A 614
VAL A 588
GLY A 608
LEU A 675
None
1.41A16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Homo
sapiens)		5 / 10LEU A 110
VAL A 156
GLY A 153
TRP A  75
LEU A  56
None
1.49A11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE
(Homo
sapiens)		5 / 10LEU A 110
VAL A 156
VAL A 149
TRP A  75
LEU A  56
None
1.32A11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		2p6n ATP-DEPENDENT RNA
HELICASE DDX41
(Homo
sapiens)		5 / 10LEU A 545
VAL A 559
VAL A 412
TYR A 414
LEU A 566
None
1.27A19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		2vkp BTB/POZ
DOMAIN-CONTAINING
PROTEIN 6
(Homo
sapiens)		5 / 10LEU A  66
VAL A  93
TYR A  91
GLY A  33
TYR A  70
None
1.12A25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		3l15 TRANSCRIPTIONAL
ENHANCER FACTOR
TEF-4
(Homo
sapiens)		5 / 10VAL A 252
VAL A 329
TYR A 327
TRP A 308
LEU A 306
None
1.40A17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens)		5 / 10LEU A 401
VAL A 335
VAL A 367
GLY A 345
LEU A 105
None
None
None
ACJ  A 478 (-3.6A)
None
1.33A9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		3uit INAD-LIKE PROTEIN,
MAGUK P55 SUBFAMILY
MEMBER 5, PROTEIN
LIN-7 HOMOLOG B
(Homo
sapiens;
Mus
musculus;
Rattus
norvegicus)		5 / 10LEU A 178
VAL A 185
VAL A 196
TYR A 253
GLY A 193
None
1.39A14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE
(Homo
sapiens)		5 / 10LEU B1597
VAL B1617
VAL B1632
GLY B1618
LEU B1590
None
1.41A4.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		4xii CHOLINESTERASE
(Homo
sapiens)		5 / 10LEU A 403
VAL A 319
VAL A 321
TYR A 500
GLY A 320
None
1.30A10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		5aj1 SWI/SNF-RELATED
MATRIX-ASSOCIATED
ACTIN-DEPENDENT
REGULATOR OF
CHROMATIN SUBFAMILY
B MEMBER 1
(Homo
sapiens)		5 / 10LEU A  36
TYR A  47
GLY A  29
LEU A 100
TYR A  35
None
1.45A20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens)		5 / 10LEU A 669
VAL A 614
VAL A 588
GLY A 608
LEU A 675
None
1.46A16.84