POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CI1_B_EF2B1429_1
(PROTEIN CEREBLON)		2a3k PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 7,
ISOFORM 1
(Homo
sapiens)		5 / 10PRO A 171
HIS A 290
SER A 177
TRP A 180
PHE A 218
None
1.31A22.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CI1_B_EF2B1429_1
(PROTEIN CEREBLON)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		10 / 10ASN Z 351
PRO Z 352
HIS Z 353
HIS Z 357
HIS Z 378
SER Z 379
TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.9A)
None
85C  Z 502 (-3.8A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
0.50A78.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CI1_B_EF2B1429_1
(PROTEIN CEREBLON)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		6 / 10ASN Z 351
PRO Z 352
HIS Z 357
HIS Z 378
SER Z 379
PHE Z 381
85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
None
85C  Z 502 (-3.8A)
85C  Z 502 (-3.2A)
None
1.39A78.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TZC_A_EF2A504_1
(PROTEIN CEREBLON)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		4 / 5TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
0.43A33.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TZC_C_EF2C502_1
(PROTEIN CEREBLON)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		4 / 5TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
0.42A33.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZC_D_EF2D505_1
(PROTEIN CEREBLON)		2is7 ALDOSE REDUCTASE
(Homo
sapiens)		4 / 8THR A 140
HIS A 306
TRP A  79
PHE A 122
None
None
None
2CL  A 317 ( 4.9A)
1.47A15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZC_D_EF2D505_1
(PROTEIN CEREBLON)		3auv SC-DSFV DERIVED FROM
THE G6-FAB
(Homo
sapiens)		4 / 8TYR A 193
TRP A 181
TRP A 167
PHE A 235
None
1.37A18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZC_D_EF2D505_1
(PROTEIN CEREBLON)		3ii6 DNA LIGASE 4
(Homo
sapiens)		4 / 8TYR X 698
THR X 697
TRP X 725
TRP X 738
None
1.48A18.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TZC_D_EF2D505_1
(PROTEIN CEREBLON)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		4 / 8TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
0.45A33.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_A_EF2A151_1
(CEREBLON ISOFORM 4)		2d7t ANTI
POLYHYDROXYBUTYRATE
ANTIBODY FV, HEAVY
CHAIN
(Homo
sapiens)		4 / 7ASN H  52
PRO H  53
TRP H  50
TYR H  60
None
1.19A22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_A_EF2A151_1
(CEREBLON ISOFORM 4)		3lpp SUCRASE-ISOMALTASE
(Homo
sapiens)		4 / 7ASN A 319
PRO A 315
PHE A 670
TYR A 660
None
1.47A9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_A_EF2A151_1
(CEREBLON ISOFORM 4)		4cak INTEGRIN ALPHA-IIB
(Homo
sapiens)		4 / 7ASN A 227
PHE A 231
TRP A 162
TRP A 260
None
1.38A8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_A_EF2A151_1
(CEREBLON ISOFORM 4)		4ot1 SM5-1 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 7ASN H  52
PRO H  53
TRP H  50
TYR H  60
None
1.23A18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_A_EF2A151_1
(CEREBLON ISOFORM 4)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		5 / 7ASN Z 351
PRO Z 352
TRP Z 380
TRP Z 386
TRP Z 400
85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
0.53A16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_B_EF2B151_1
(CEREBLON ISOFORM 4)		2d7t ANTI
POLYHYDROXYBUTYRATE
ANTIBODY FV, HEAVY
CHAIN
(Homo
sapiens)		4 / 7ASN H  52
PRO H  53
TRP H  50
TYR H  60
None
1.17A22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_B_EF2B151_1
(CEREBLON ISOFORM 4)		4cak INTEGRIN ALPHA-IIB
(Homo
sapiens)		4 / 7ASN A 227
PHE A 231
TRP A 162
TRP A 260
None
1.38A8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_B_EF2B151_1
(CEREBLON ISOFORM 4)		4ot1 SM5-1 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 7ASN H  52
PRO H  53
TRP H  50
TYR H  60
None
1.20A18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_B_EF2B151_1
(CEREBLON ISOFORM 4)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		5 / 7ASN Z 351
PRO Z 352
TRP Z 380
TRP Z 386
TRP Z 400
85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
0.46A16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_C_EF2C151_1
(CEREBLON ISOFORM 4)		4z0x ANTIBODY HC26AM
HEAVY CHAIN VARIABLE
DOMAIN
(Homo
sapiens)		4 / 7ASN B  56
PRO B  78
PHE B  76
TYR B 131
None
1.36A21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_C_EF2C151_1
(CEREBLON ISOFORM 4)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		4 / 7ASN Z 351
PRO Z 352
TRP Z 380
TRP Z 400
85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.7A)
0.78A16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_C_EF2C151_1
(CEREBLON ISOFORM 4)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		4 / 7PRO Z 352
TRP Z 380
TRP Z 386
TRP Z 400
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
0.57A16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_A_EF2A151_1
(CEREBLON ISOFORM 4)		2jxy MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		4 / 7ASN A 465
PHE A 468
TRP A 307
PHE A 300
None
1.40A17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_A_EF2A151_1
(CEREBLON ISOFORM 4)		4cak INTEGRIN ALPHA-IIB
(Homo
sapiens)		4 / 7ASN A 227
PHE A 231
TRP A 162
TRP A 260
None
1.41A8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_A_EF2A151_1
(CEREBLON ISOFORM 4)		4er6 HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC
(Homo
sapiens)		4 / 7ASN A 241
PRO A 130
PHE A 243
PHE A 272
AW2  A 502 (-4.3A)
None
None
None
1.47A16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_A_EF2A151_1
(CEREBLON ISOFORM 4)		4gba DCN1-LIKE PROTEIN 3
(Homo
sapiens)		4 / 7ASN A 244
PHE A 187
TRP A 209
PHE A 213
None
0.91A20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_A_EF2A151_1
(CEREBLON ISOFORM 4)		4h1s 5'-NUCLEOTIDASE
(Homo
sapiens)		4 / 7ASN A 186
PRO A 187
PHE A 120
PHE A  93
None
1.34A10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_A_EF2A151_1
(CEREBLON ISOFORM 4)		4um2 TELOMERASE-BINDING
PROTEIN EST1A
(Homo
sapiens)		4 / 7ASN A1041
PRO A1043
TRP A1040
PHE A1134
None
1.08A11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_A_EF2A151_1
(CEREBLON ISOFORM 4)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		6 / 7ASN Z 351
PRO Z 352
TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
0.50A16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_A_EF2A151_1
(CEREBLON ISOFORM 4)		5lgd PLATELET
GLYCOPROTEIN 4
(Homo
sapiens)		4 / 7ASN A 390
PRO A 412
PHE A  68
PHE A 201
None
None
None
PLM  A 512 (-4.9A)
1.49A14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_B_EF2B151_1
(CEREBLON ISOFORM 4)		2jxy MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		4 / 7ASN A 465
PHE A 468
TRP A 307
PHE A 300
None
1.36A17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_B_EF2B151_1
(CEREBLON ISOFORM 4)		4gba DCN1-LIKE PROTEIN 3
(Homo
sapiens)		4 / 7ASN A 244
PHE A 187
TRP A 209
PHE A 213
None
1.02A20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_B_EF2B151_1
(CEREBLON ISOFORM 4)		4um2 TELOMERASE-BINDING
PROTEIN EST1A
(Homo
sapiens)		4 / 7ASN A1041
PRO A1043
TRP A1040
PHE A1134
None
1.11A11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_B_EF2B151_1
(CEREBLON ISOFORM 4)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		6 / 7ASN Z 351
PRO Z 352
TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
0.47A16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_C_EF2C151_1
(CEREBLON ISOFORM 4)		1vka MICROTUBULE-ASSOCIAT
ED PROTEIN RP/EB
FAMILY MEMBER 1
(Homo
sapiens)		4 / 7ASN A 118
PHE A 115
TRP A 110
PHE A 107
None
1.37A22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_C_EF2C151_1
(CEREBLON ISOFORM 4)		2i32 ANTI-SILENCING
FACTOR 1 PARALOG A
(Homo
sapiens)		4 / 7ASN A  80
PRO A  81
PHE A 132
PHE A  22
None
1.44A18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_C_EF2C151_1
(CEREBLON ISOFORM 4)		2ltm NFU1 IRON-SULFUR
CLUSTER SCAFFOLD
HOMOLOG,
MITOCHONDRIAL
(Homo
sapiens)		4 / 7ASN A  22
PRO A  21
TRP A  82
PHE A  26
None
1.36A22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_C_EF2C151_1
(CEREBLON ISOFORM 4)		2qjz MICROTUBULE-ASSOCIAT
ED PROTEIN RP/EB
FAMILY MEMBER 1
(Homo
sapiens)		4 / 7ASN A 118
PHE A 115
TRP A 110
PHE A 107
None
1.40A22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_C_EF2C151_1
(CEREBLON ISOFORM 4)		2r8u MICROTUBULE-ASSOCIAT
ED PROTEIN RP/EB
FAMILY MEMBER 1
(Homo
sapiens)		4 / 7ASN A 118
PHE A 115
TRP A 110
PHE A 107
None
1.38A19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_C_EF2C151_1
(CEREBLON ISOFORM 4)		2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		4 / 7ASN A 494
PRO A 493
TRP A 257
PHE A 438
None
1.40A11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_C_EF2C151_1
(CEREBLON ISOFORM 4)		3aad HISTONE CHAPERONE
ASF1A
(Homo
sapiens)		4 / 7ASN B  80
PRO B  81
PHE B 132
PHE B  22
None
1.48A19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_C_EF2C151_1
(CEREBLON ISOFORM 4)		3co1 MICROTUBULE-ASSOCIAT
ED PROTEIN RP/EB
FAMILY MEMBER 3
(Homo
sapiens)		4 / 7ASN A 118
PHE A 115
TRP A 110
PHE A 107
None
1.42A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_C_EF2C151_1
(CEREBLON ISOFORM 4)		3kq4 CUBILIN
(Homo
sapiens)		4 / 7ASN B1066
PRO B1065
PHE B1064
PHE B1143
None
NAG  B2002 (-4.5A)
NAG  B2002 ( 4.8A)
None
1.48A14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_C_EF2C151_1
(CEREBLON ISOFORM 4)		3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens)		4 / 7ASN B 126
PHE B 491
TRP B 490
PHE B 463
None
0.83A8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_C_EF2C151_1
(CEREBLON ISOFORM 4)		4gba DCN1-LIKE PROTEIN 3
(Homo
sapiens)		4 / 7ASN A 244
PHE A 187
TRP A 209
PHE A 213
None
1.01A20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_C_EF2C151_1
(CEREBLON ISOFORM 4)		4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens)		4 / 7ASN A 235
PRO A 234
PHE A 233
PHE A 288
None
1.38A10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_C_EF2C151_1
(CEREBLON ISOFORM 4)		5bo0 HISTONE CHAPERONE
ASF1B
(Homo
sapiens)		4 / 7ASN D  80
PRO D  81
PHE D 132
PHE D  22
None
1.46A20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_C_EF2C151_1
(CEREBLON ISOFORM 4)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		5 / 7ASN Z 351
PRO Z 352
TRP Z 380
TRP Z 400
PHE Z 402
85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.7A)
None
0.72A16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_C_EF2C151_1
(CEREBLON ISOFORM 4)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		5 / 7PRO Z 352
TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
0.54A16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMH_A_EF2A151_1
(CEREBLON ISOFORM 4)		3rom ADP-RIBOSYL CYCLASE
1
(Homo
sapiens)		4 / 7ASN A 183
PRO A 184
PHE A  93
TRP A  50
None
1.36A19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMH_A_EF2A151_1
(CEREBLON ISOFORM 4)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		5 / 7ASN Z 351
PRO Z 352
TRP Z 380
TRP Z 386
TRP Z 400
85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
0.73A16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMH_A_EF2A151_1
(CEREBLON ISOFORM 4)		5t3x IOMA HEAVY CHAIN
(Homo
sapiens)		4 / 7ASN D  52
PRO D  52
PHE D  78
TYR D  59
None
1.38A20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_A_EF2A151_1
(CEREBLON ISOFORM 4)		2d7t ANTI
POLYHYDROXYBUTYRATE
ANTIBODY FV, HEAVY
CHAIN
(Homo
sapiens)		4 / 7ASN H  52
PRO H  53
TRP H  50
TYR H  60
None
1.16A22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_A_EF2A151_1
(CEREBLON ISOFORM 4)		4ot1 SM5-1 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 7ASN H  52
PRO H  53
TRP H  50
TYR H  60
None
1.20A18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_A_EF2A151_1
(CEREBLON ISOFORM 4)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		5 / 7ASN Z 351
PRO Z 352
TRP Z 380
TRP Z 386
TRP Z 400
85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
0.49A16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		1xfb ALDOLASE C
(Homo
sapiens)		4 / 8ASN A 232
PRO A 231
PHE A 270
SER A 272
None
1.45A14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		2d7t ANTI
POLYHYDROXYBUTYRATE
ANTIBODY FV, HEAVY
CHAIN
(Homo
sapiens)		4 / 8ASN H  52
PRO H  53
TRP H  50
TYR H  60
None
1.17A22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		3whe IMMUNOGLOBULIN HEAVY
CHAIN
(Homo
sapiens)		4 / 8SER M  35
TRP M  47
TRP M  50
TYR M 111
None
1.26A17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		4ot1 SM5-1 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 8ASN H  52
PRO H  53
TRP H  50
TYR H  60
None
1.20A18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		6 / 8ASN Z 351
PRO Z 352
SER Z 379
TRP Z 380
TRP Z 386
TRP Z 400
85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
0.47A16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		5iy6 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPB
SUBUNIT
(Homo
sapiens)		4 / 8ASN V 539
PRO V 538
PHE V 703
SER V 704
None
1.45A10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPB
SUBUNIT,XPB,TFIIH
BASAL TRANSCRIPTION
FACTOR COMPLEX
HELICASE XPB SUBUNIT
(Homo
sapiens)		4 / 8ASN A 539
PRO A 538
PHE A 703
SER A 704
None
1.38A12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMJ_A_EF2A151_1
(CEREBLON ISOFORM 4)		4ot1 SM5-1 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 7ASN H  52
PRO H  53
TRP H  50
TYR H  60
None
1.17A18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMJ_A_EF2A151_1
(CEREBLON ISOFORM 4)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		5 / 7ASN Z 351
PRO Z 352
TRP Z 380
TRP Z 386
TRP Z 400
85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
0.46A16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMJ_B_EF2B151_1
(CEREBLON ISOFORM 4)		2d7t ANTI
POLYHYDROXYBUTYRATE
ANTIBODY FV, HEAVY
CHAIN
(Homo
sapiens)		4 / 7ASN H  52
PRO H  53
TRP H  50
TYR H  60
None
1.14A22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMJ_B_EF2B151_1
(CEREBLON ISOFORM 4)		4cak INTEGRIN ALPHA-IIB
(Homo
sapiens)		4 / 7ASN A 227
PHE A 231
TRP A 162
TRP A 260
None
1.42A8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMJ_B_EF2B151_1
(CEREBLON ISOFORM 4)		4ot1 SM5-1 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 7ASN H  52
PRO H  53
TRP H  50
TYR H  60
None
1.18A18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMJ_B_EF2B151_1
(CEREBLON ISOFORM 4)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		5 / 7ASN Z 351
PRO Z 352
TRP Z 380
TRP Z 386
TRP Z 400
85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
0.42A16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		3som METHYLMALONIC
ACIDURIA AND
HOMOCYSTINURIA TYPE
C PROTEIN
(Homo
sapiens)		4 / 8PRO A  56
PHE A 223
PHE A 154
TYR A 205
None
FLC  A 501 (-3.9A)
None
None
1.17A19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		4gbr BETA-2 ADRENERGIC
RECEPTOR
(Homo
sapiens)		4 / 8PHE A 104
TRP A  99
TRP A 105
TRP A 109
None
1.50A16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		4ovn SODIUM CHANNEL
PROTEIN TYPE 5
SUBUNIT ALPHA
(Homo
sapiens)		4 / 8ASN F1883
PRO F1884
PHE F1879
TYR F1795
None
1.40A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		5dj4 SESTRIN-2
(Homo
sapiens)		4 / 8PHE A 367
PHE A 401
TRP A 394
TYR A 405
None
1.30A13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		5 / 8ASN Z 351
PRO Z 352
TRP Z 380
TRP Z 386
TRP Z 400
85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
0.62A16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		5xgj PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM
(Homo
sapiens)		4 / 8ASN A 785
PRO A 786
PHE A 794
TRP A 783
None
1.50A21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_B_EF2B151_1
(CEREBLON ISOFORM 4)		3lpp SUCRASE-ISOMALTASE
(Homo
sapiens)		4 / 7ASN A 319
PRO A 315
PHE A 670
TYR A 660
None
1.49A9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_B_EF2B151_1
(CEREBLON ISOFORM 4)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		5 / 7ASN Z 351
PRO Z 352
TRP Z 380
TRP Z 386
TRP Z 400
85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
0.59A16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_A_EF2A202_0
(CEREBLON ISOFORM 4)		3lpp SUCRASE-ISOMALTASE
(Homo
sapiens)		4 / 7ASN A 319
PRO A 315
PHE A 670
TYR A 660
None
1.48A8.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_A_EF2A202_0
(CEREBLON ISOFORM 4)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		5 / 7ASN Z 351
PRO Z 352
TRP Z 380
TRP Z 386
TRP Z 400
85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
0.56A13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_B_EF2B202_0
(CEREBLON ISOFORM 4)		2d7t ANTI
POLYHYDROXYBUTYRATE
ANTIBODY FV, HEAVY
CHAIN
(Homo
sapiens)		4 / 7ASN H  52
PRO H  53
TRP H  50
TYR H  60
None
1.24A21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_B_EF2B202_0
(CEREBLON ISOFORM 4)		2nt2 PROTEIN PHOSPHATASE
SLINGSHOT HOMOLOG 2
(Homo
sapiens)		4 / 7ASN A 322
PRO A 308
PHE A 316
TYR A 354
None
1.30A16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_B_EF2B202_0
(CEREBLON ISOFORM 4)		3lpp SUCRASE-ISOMALTASE
(Homo
sapiens)		4 / 7ASN A 319
PRO A 315
PHE A 670
TYR A 660
None
1.45A8.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_B_EF2B202_0
(CEREBLON ISOFORM 4)		4ot1 SM5-1 FAB HEAVY
CHAIN
(Homo
sapiens)		4 / 7ASN H  52
PRO H  53
TRP H  50
TYR H  60
None
1.27A20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_B_EF2B202_0
(CEREBLON ISOFORM 4)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		5 / 7ASN Z 351
PRO Z 352
TRP Z 380
TRP Z 386
TRP Z 400
85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
0.52A13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_B_EF2B202_0
(CEREBLON ISOFORM 4)		6f1d COMPLEMENT C1R
SUBCOMPONENT
(Homo
sapiens)		4 / 7PRO A 256
PHE A 250
TRP A 281
TYR A 197
None
1.41A22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_A_EF2A501_1
(PROTEIN CEREBLON)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		4 / 5TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
0.43A21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_B_EF2B501_1
(PROTEIN CEREBLON)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		4 / 5TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
0.39A21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_D_EF2D501_1
(PROTEIN CEREBLON)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		4 / 5TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
0.43A21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_E_EF2E501_1
(PROTEIN CEREBLON)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		4 / 5TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
0.41A21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_G_EF2G501_1
(PROTEIN CEREBLON)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		4 / 7TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
0.43A21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_H_EF2H501_1
(PROTEIN CEREBLON)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		4 / 5TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
0.39A21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_J_EF2J501_1
(PROTEIN CEREBLON)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		4 / 5TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
0.39A21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_K_EF2K501_1
(PROTEIN CEREBLON)		2is7 ALDOSE REDUCTASE
(Homo
sapiens)		4 / 7HIS A 306
TRP A  79
PHE A 122
THR A 140
None
None
2CL  A 317 ( 4.9A)
None
1.47A12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_K_EF2K501_1
(PROTEIN CEREBLON)		4yo2 TRANSCRIPTION FACTOR
E2F8
(Homo
sapiens)		4 / 7HIS A 181
TRP A 180
PHE A 125
THR A 189
None
1.48A14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_K_EF2K501_1
(PROTEIN CEREBLON)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		4 / 7TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
0.43A21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_M_EF2M501_1
(PROTEIN CEREBLON)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		4 / 5TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
0.43A21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_N_EF2N501_1
(PROTEIN CEREBLON)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		4 / 5TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
0.38A21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_P_EF2P501_1
(PROTEIN CEREBLON)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		4 / 5TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
0.39A21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_Q_EF2Q501_1
(PROTEIN CEREBLON)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		4 / 5TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
0.39A21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_S_EF2S501_1
(PROTEIN CEREBLON)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		4 / 5TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
0.41A21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_T_EF2T501_1
(PROTEIN CEREBLON)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		4 / 7TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
0.41A21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_V_EF2V501_1
(PROTEIN CEREBLON)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		4 / 5TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
0.38A21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_Y_EF2Y501_1
(PROTEIN CEREBLON)		2is7 ALDOSE REDUCTASE
(Homo
sapiens)		4 / 7THR A 140
HIS A 306
TRP A  79
PHE A 122
None
None
None
2CL  A 317 ( 4.9A)
1.47A12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_Y_EF2Y501_1
(PROTEIN CEREBLON)		4yo2 TRANSCRIPTION FACTOR
E2F8
(Homo
sapiens)		4 / 7THR A 189
HIS A 181
TRP A 180
PHE A 125
None
1.49A14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YIZ_Y_EF2Y501_1
(PROTEIN CEREBLON)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		4 / 7TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
0.43A21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_A_EF2A501_1
(PROTEIN CEREBLON)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		4 / 5TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
0.40A21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_B_EF2B501_1
(PROTEIN CEREBLON)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		4 / 5TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
0.39A21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_D_EF2D501_1
(PROTEIN CEREBLON)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		4 / 5TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
0.42A21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_E_EF2E501_1
(PROTEIN CEREBLON)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		4 / 5TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
0.40A21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_G_EF2G501_1
(PROTEIN CEREBLON)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		4 / 7TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
0.41A21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_H_EF2H501_1
(PROTEIN CEREBLON)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		4 / 5TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
0.38A21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_J_EF2J501_1
(PROTEIN CEREBLON)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		4 / 5TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
0.39A21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_K_EF2K501_1
(PROTEIN CEREBLON)		2is7 ALDOSE REDUCTASE
(Homo
sapiens)		4 / 7HIS A 306
TRP A  79
PHE A 122
THR A 140
None
None
2CL  A 317 ( 4.9A)
None
1.47A12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_K_EF2K501_1
(PROTEIN CEREBLON)		4yo2 TRANSCRIPTION FACTOR
E2F8
(Homo
sapiens)		4 / 7HIS A 181
TRP A 180
PHE A 125
THR A 189
None
1.49A14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_K_EF2K501_1
(PROTEIN CEREBLON)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		4 / 7TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
0.39A21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_M_EF2M501_1
(PROTEIN CEREBLON)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		4 / 5TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
0.40A21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_N_EF2N501_1
(PROTEIN CEREBLON)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		4 / 5TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
0.39A21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_P_EF2P501_1
(PROTEIN CEREBLON)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		4 / 5TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
0.38A21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_Q_EF2Q501_1
(PROTEIN CEREBLON)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		4 / 5TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
0.39A21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_S_EF2S501_1
(PROTEIN CEREBLON)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		4 / 5TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
0.39A21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_T_EF2T501_1
(PROTEIN CEREBLON)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		4 / 7TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
0.41A21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_V_EF2V501_1
(PROTEIN CEREBLON)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		4 / 5TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
0.38A21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_Y_EF2Y501_1
(PROTEIN CEREBLON)		2is7 ALDOSE REDUCTASE
(Homo
sapiens)		4 / 7THR A 140
HIS A 306
TRP A  79
PHE A 122
None
None
None
2CL  A 317 ( 4.9A)
1.48A12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_Y_EF2Y501_1
(PROTEIN CEREBLON)		4yo2 TRANSCRIPTION FACTOR
E2F8
(Homo
sapiens)		4 / 7THR A 189
HIS A 181
TRP A 180
PHE A 125
None
1.49A14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ0_Y_EF2Y501_1
(PROTEIN CEREBLON)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		4 / 7TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
0.41A21.39