POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_B_EDTB1511_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE
(Homo
sapiens)		4 / 8TYR A 651
TRP A 550
TRP A 647
TYR A 230
None
1.48A21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_B_EDTB1511_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5
(Homo
sapiens)		4 / 8TYR A  64
ARG A  61
TYR A 223
THR A 175
GLU  A 506 (-4.6A)
None
GLU  A 506 (-3.4A)
GLU  A 506 (-3.0A)
1.46A20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_B_EDTB1511_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		4qn9 N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D
(Homo
sapiens)		4 / 8MET A 136
ARG A 202
TYR A 110
THR A 128
None
1.28A22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])		1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens)		5 / 12PRO A 195
GLY A 182
PHE A  96
THR A 188
TYR A  97
None
1.33A22.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])		1k6m 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE
2-PHOSPHATASE
(Homo
sapiens)		12 / 12PRO A  50
LYS A  54
THR A  55
ASN A  76
GLY A  78
ARG A  82
PHE A  93
ARG A 104
ALA A 131
THR A 132
ARG A 195
TYR A 199
None
AGS  A 503 (-2.9A)
AGS  A 503 (-3.3A)
AGS  A 503 ( 4.3A)
None
None
None
None
None
None
None
None
0.53A64.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])		1rkb PROTEIN AD-004
(Homo
sapiens)		5 / 12PRO A  12
LYS A  16
ASN A  33
GLY A  35
ARG A  39
SO4  A 201 (-4.6A)
SO4  A 201 (-2.7A)
None
None
None
0.96A16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])		1rkb PROTEIN AD-004
(Homo
sapiens)		5 / 12PRO A  12
LYS A  16
THR A  17
ASN A  33
GLY A  35
SO4  A 201 (-4.6A)
SO4  A 201 (-2.7A)
SO4  A 201 (-3.8A)
None
None
0.52A16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])		2aw5 NADP-DEPENDENT MALIC
ENZYME
(Homo
sapiens)		5 / 12PRO A 185
GLY A 172
PHE A  86
THR A 178
TYR A  87
None
1.35A22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])		2c47 CASEIN KINASE 1
GAMMA 2 ISOFORM
(Homo
sapiens)		5 / 12PRO A 251
GLY A 268
ARG A 295
ALA A 273
THR A 274
None
1.40A20.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])		4d4l 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3
(Homo
sapiens)		12 / 12PRO A  43
LYS A  47
THR A  48
ASN A  69
GLY A  71
ARG A  75
PHE A  87
ARG A  98
ALA A 125
THR A 126
ARG A 189
TYR A 193
PO4  A1447 (-4.7A)
PO4  A1447 (-2.8A)
PO4  A1447 (-3.8A)
None
None
None
None
None
None
None
None
None
0.39A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])		5ajz 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3
(Homo
sapiens)		12 / 12PRO A  43
LYS A  47
THR A  48
ASN A  69
GLY A  71
ARG A  75
PHE A  87
ARG A  98
ALA A 125
THR A 126
ARG A 189
TYR A 193
PO4  A1448 (-4.5A)
PO4  A1448 (-2.7A)
PO4  A1448 (-3.9A)
None
None
None
None
None
None
None
None
None
0.37A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])		5htk 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 2
(Homo
sapiens)		12 / 12PRO A  47
LYS A  51
THR A  52
ASN A  73
GLY A  75
ARG A  79
PHE A  91
ARG A 102
ALA A 129
THR A 130
ARG A 193
TYR A 197
ATP  A 602 (-4.3A)
ATP  A 602 (-2.7A)
ATP  A 602 ( 3.1A)
ATP  A 602 ( 3.9A)
FLC  A 601 (-3.0A)
ATP  A 602 ( 4.1A)
FLC  A 601 ( 4.8A)
GOL  A 606 ( 2.0A)
FLC  A 601 (-3.3A)
FLC  A 601 (-2.7A)
None
GOL  A 606 ( 3.4A)
0.54A67.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])		5jzv ADENYLATE KINASE
ISOENZYME 6
(Homo
sapiens)		6 / 12PRO A  12
LYS A  16
THR A  17
ASN A  33
GLY A  35
ARG A  39
ADP  A 201 ( 4.9A)
ADP  A 201 (-2.8A)
ADP  A 201 (-4.3A)
None
None
None
0.76A16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L7K_A_EDTA739_0
(TEICHOIC ACID
BIOSYNTHESIS PROTEIN
F)		3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 1
(Homo
sapiens)		4 / 5LEU A  28
LYS A  25
ARG A  33
LYS A  32
None
1.46A18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RNJ_A_EDTA1_0
(BRAIN-SPECIFIC
ANGIOGENESIS
INHIBITOR
1-ASSOCIATED PROTEIN
2)		2zu6 EUKARYOTIC
INITIATION FACTOR
4A-I
(Homo
sapiens)		4 / 4LYS A 291
ARG A 295
LEU A 260
ASP A 261
None
1.25A9.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RNJ_A_EDTA1_0
(BRAIN-SPECIFIC
ANGIOGENESIS
INHIBITOR
1-ASSOCIATED PROTEIN
2)		3rnj BRAIN-SPECIFIC
ANGIOGENESIS
INHIBITOR
1-ASSOCIATED PROTEIN
2
(Homo
sapiens)		4 / 4LYS A 380
ARG A 433
LEU A 435
ASP A 436
EDT  A   1 (-2.7A)
EDT  A   1 (-2.7A)
EDT  A   1 (-4.3A)
EDT  A   1 (-3.8A)
0.00A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		1w6v UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15
(Homo
sapiens)		5 / 11THR A  94
GLY A  96
PRO A  93
ARG A  25
ASP A  15
None
1.15A17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		3um1 BRO1
DOMAIN-CONTAINING
PROTEIN BROX
(Homo
sapiens)		5 / 11THR A 369
THR A  25
GLY A  26
PRO A  27
ASP A 374
None
1.32A16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		4k12 COMPLEMENT FACTOR H
(Homo
sapiens)		5 / 11THR A  44
GLY A  45
THR A  40
GLY A  41
ASP A  56
None
1.32A14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		5gva WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1
(Homo
sapiens)		5 / 11THR A  13
THR A  17
GLY A  32
ARG A  38
ASP A 292
None
1.50A17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens)		5 / 11THR A1910
GLY A1909
ARG A2358
THR A1913
ASP A2320
None
ADP  A4801 (-3.8A)
ADP  A4801 (-2.9A)
ADP  A4801 (-3.8A)
ADP  A4801 (-3.3A)
1.16A2.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens)		5 / 11THR A1910
GLY A1909
THR A1913
PRO A1904
ASP A2320
None
ADP  A4801 (-3.8A)
ADP  A4801 (-3.8A)
None
ADP  A4801 (-3.3A)
1.36A2.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		5v4b F-BOX/WD
REPEAT-CONTAINING
PROTEIN 7
(Homo
sapiens)		5 / 11THR B2692
GLY B2691
THR B2695
GLY B2687
ASP B2381
None
1.06A13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		5vhj 26S PROTEASOME
REGULATORY SUBUNIT
10B
(Homo
sapiens)		5 / 11THR E 178
GLY E 177
PRO E 176
PRO E 304
ASP E 302
None
1.02A18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens)		5 / 11PRO A1706
THR A2044
GLY A2045
ARG A1856
ASP A1707
None
1.10Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WFA_B_EDTB802_0
(ALPHA-GLUCOSIDASE)		3ohm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens)		4 / 6TYR B 157
ARG B 154
ASP B  46
ASN B  48
None
1.16A22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WFA_B_EDTB802_0
(ALPHA-GLUCOSIDASE)		4lsq HEAVY CHAIN OF
ANTIBODY VRC-CH31
LIGHT CHAIN OF
ANTIBODY VRC-CH31
WITH N70D MUTATION
(Homo
sapiens;
Homo
sapiens)		4 / 6TYR L  91
ASP L  50
ASN L  34
TYR H 100
None
1.49A15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WFA_B_EDTB802_0
(ALPHA-GLUCOSIDASE)		4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens)		4 / 6TYR B 157
ARG B 154
ASP B  46
ASN B  48
None
1.28A22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WFA_B_EDTB802_0
(ALPHA-GLUCOSIDASE)		6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens)		4 / 6ARG A 390
ASN A 394
TYR A 329
LYS A 328
None
1.31Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OES_A_EDTA601_0
(NIKA PROTEIN)		3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE
(Homo
sapiens)		4 / 6TYR A 651
TRP A 550
TRP A 647
TYR A 230
None
1.40A23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		1yb5 QUINONE
OXIDOREDUCTASE
(Homo
sapiens)		4 / 8THR A 113
THR A  95
PRO A  33
ILE A  99
 CL  A 818 (-3.2A)
None
None
CL  A 818 ( 4.9A)
1.12A24.72
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		2loz TENSIN-LIKE C1
DOMAIN-CONTAINING
PHOSPHATASE
(Homo
sapiens)		4 / 8THR A1282
ARG A1353
PRO A1350
ILE A1365
None
1.14A19.50
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens)		4 / 8SER A 442
THR A 408
PRO A 143
ILE A 423
None
1.08A19.96
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens)		4 / 8SER A 674
THR A 503
THR A 505
ILE A 523
GLU  A 301 (-3.2A)
GLU  A 301 (-3.9A)
None
None
0.92A20.30
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		3alq TUMOR NECROSIS
FACTOR RECEPTOR
SUPERFAMILY MEMBER
1B
(Homo
sapiens)		4 / 8SER R 152
THR R 150
PRO R 130
ILE R 156
None
1.12A19.26
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		3nvn PLEXIN-C1
(Homo
sapiens)		4 / 8SER B 311
THR B 325
ARG B 100
PRO B 101
None
1.04A18.26
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		3von UBIQUITIN
THIOESTERASE OTUB1
(Homo
sapiens)		4 / 8TYR A  79
LYS A  78
PRO A 255
ILE A 231
None
0.99A22.61
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens)		4 / 8THR A1632
THR A1858
PRO A1639
ILE A1635
None
1.14A16.34
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct)		4 / 8SER A2870
THR A2868
ARG A3341
ILE A3386
None
0.75A5.89
2.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		5euo PF6 TCR BETA CHAIN
(Homo
sapiens)		5 / 8TYR F  45
LYS F  55
SER F  63
THR F  75
THR F  77
None
0.61A95.83
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		5hvf CARBOXYPEPTIDASE B2
(Homo
sapiens)		4 / 8THR A 367
THR A 369
PRO A 381
ILE A 329
None
1.12A21.10
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens)		4 / 8SER A 584
THR A 565
THR A 659
ILE A 594
None
0.91A14.22
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_J_EDTJ301_0
(TCRBETA CHAIN)		1vec ATP-DEPENDENT RNA
HELICASE P54
(Homo
sapiens)		4 / 5TYR A 139
GLU A 236
GLY A 132
SER A 136
None
1.32A21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_J_EDTJ301_0
(TCRBETA CHAIN)		2xub DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Homo
sapiens)		4 / 5TYR A 334
LYS A 325
GLY A 330
SER A 290
None
1.02A18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_J_EDTJ301_0
(TCRBETA CHAIN)		4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 A CHAIN
(Homo
sapiens)		4 / 5TYR G 410
GLU G 424
GLY G 423
SER G 421
None
1.45A20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_J_EDTJ301_0
(TCRBETA CHAIN)		4grl MHC CLASS II
HLA-DQ-ALPHA CHAIN
(Homo
sapiens)		4 / 5TYR A  13
LYS A  67
GLY A  17
SER A  19
None
1.07A22.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JHD_J_EDTJ301_0
(TCRBETA CHAIN)		4zdh BETA CHAIN OF JKF6
T-CELL
RECEPTOR,PROTEIN
TRBV28
(Homo
sapiens)		4 / 5TYR B  47
LYS B  57
GLY B  63
SER B  65
None
0.54A77.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JHD_J_EDTJ301_0
(TCRBETA CHAIN)		5euo PF6 TCR BETA CHAIN
(Homo
sapiens)		4 / 5TYR F  45
LYS F  55
GLY F  61
SER F  63
None
0.51A95.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_J_EDTJ301_0
(TCRBETA CHAIN)		5for PHOSPHOINOSITIDE
3-KINASE ADAPTER
PROTEIN 1
(Homo
sapiens)		4 / 5TYR A  13
GLU A  47
GLY A  45
SER A  14
None
1.34A21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_J_EDTJ301_0
(TCRBETA CHAIN)		6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10
(Homo
sapiens)		4 / 5TYR A 350
LYS A 348
GLU A 345
GLY A 341
None
1.17Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_J_EDTJ301_0
(TCRBETA CHAIN)		6fur HUMAN F11 T-CELL
RECEPTOR
(Homo
sapiens)		4 / 5TYR B  46
LYS B  56
GLY B  62
SER B  64
None
None
None
EDO  B 302 (-3.3A)
0.62Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_A_EDTA609_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5
(Homo
sapiens)		4 / 8TYR A  64
ARG A  61
TYR A 223
THR A 175
GLU  A 506 (-4.6A)
None
GLU  A 506 (-3.4A)
GLU  A 506 (-3.0A)
1.47A20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_A_EDTA609_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		4qn9 N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D
(Homo
sapiens)		4 / 8MET A 136
ARG A 202
TYR A 110
THR A 128
None
1.29A22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_A_EDTA609_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5
(Homo
sapiens)		4 / 8TYR A  64
ARG A  61
TYR A 223
THR A 175
GLU  A 506 (-4.6A)
None
GLU  A 506 (-3.4A)
GLU  A 506 (-3.0A)
1.47A20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_A_EDTA609_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		4qn9 N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D
(Homo
sapiens)		4 / 8MET A 136
ARG A 202
TYR A 110
THR A 128
None
1.29A22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		2r3v MEVALONATE KINASE
(Homo
sapiens)		4 / 6ASN A 186
THR A 209
ASN A 205
ILE A 221
None
1.32A22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		2yek BROMODOMAIN-CONTAINI
NG PROTEIN 2
(Homo
sapiens)		4 / 6THR A  76
ASN A  77
ARG A  74
GLU A 183
None
1.21A14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		3ebb PHOSPHOLIPASE
A2-ACTIVATING
PROTEIN
(Homo
sapiens)		4 / 6THR A 704
ASN A 708
ARG A 744
GLU A 539
None
1.06A20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		3maz SIGNAL-TRANSDUCING
ADAPTOR PROTEIN 1
(Homo
sapiens)		4 / 6THR A 260
ASN A 263
ILE A 219
GLU A 218
None
1.26A15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA
(Homo
sapiens;
Escherichia
virus
T4)		4 / 6THR A  64
ASN A  65
ARG A 128
GLU A 389
None
0.85A29.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		3qak ADENOSINE RECEPTOR
A2A,LYSOZYME CHIMERA
(Homo
sapiens;
Escherichia
virus
T4)		5 / 6ASN A  39
THR A  41
ASN A  42
ARG A 102
GLU A 294
None
0.67A71.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		3qak ADENOSINE RECEPTOR
A2A,LYSOZYME CHIMERA
(Homo
sapiens;
Escherichia
virus
T4)		5 / 6ASN A  39
THR A  41
ASN A  42
ILE A 292
GLU A 294
None
0.51A71.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		4lg9 F-BOX-LIKE/WD
REPEAT-CONTAINING
PROTEIN TBL1XR1
(Homo
sapiens)		4 / 6THR A 423
ARG A 425
ILE A 394
GLU A 393
None
1.15A20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		4x0q DNA POLYMERASE THETA
(Homo
sapiens)		4 / 6THR A2471
ARG A2448
ILE A2453
GLU A2465
None
0.96A19.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		5g53 ADENOSINE RECEPTOR
A2A
(Homo
sapiens)		4 / 6ASN A  39
THR A  41
ASN A  42
ILE A 292
None
0.71A69.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		5h1k GEM-ASSOCIATED
PROTEIN 5
(Homo
sapiens)		4 / 6THR A 250
ARG A 252
ILE A 198
GLU A 197
None
None
None
U  C   3 ( 4.9A)
1.22A20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		5nnz DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1
(Homo
sapiens)		4 / 6THR B 410
ARG B 412
ILE B 390
GLU B 389
None
1.23A22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		5vni PROTEIN TRANSPORT
PROTEIN SEC24A
VESICLE-TRAFFICKING
PROTEIN SEC22B
(Homo
sapiens;
Mus
musculus)		4 / 6THR B 540
ASN B 539
ILE C 113
GLU B 815
None
1.23A19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		5zbh NEUROPEPTIDE Y
RECEPTOR TYPE 1,T4
LYSOZYME,NEUROPEPTID
E Y RECEPTOR TYPE 1
(Homo
sapiens;
Escherichia
virus
T4)		4 / 6ASN A  73
THR A  75
ASN A  76
ARG A 138
None
0.92Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		5zbq NEUROPEPTIDE Y
RECEPTOR TYPE 1,T4
LYSOZYME
(Homo
sapiens;
Escherichia
virus
T4)		4 / 6ASN A  73
THR A  75
ASN A  76
ARG A 138
None
1.09Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		6aqf ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A
(Escherichia
coli;
Homo
sapiens)		6 / 6ASN A  39
THR A  41
ASN A  42
ARG A 102
ILE A 292
GLU A 294
None
0.56Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UWC_G_EDTG407_0
(INTERLEUKIN-3
RECEPTOR SUBUNIT
ALPHA)		1lpb LIPASE
(Homo
sapiens)		4 / 5TRP B 106
HIS B  75
SER B 110
ARG B 111
None
None
None
BOG  B 450 (-3.6A)
1.40A22.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UWC_G_EDTG407_0
(INTERLEUKIN-3
RECEPTOR SUBUNIT
ALPHA)		4jzj INTERLEUKIN-3
RECEPTOR SUBUNIT
ALPHA
(Homo
sapiens)		5 / 5TRP C 113
HIS C 115
SER C 121
LYS C 154
ARG C 165
None
0.69A98.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		1cjy PROTEIN (CYTOSOLIC
PHOSPHOLIPASE A2)
(Homo
sapiens)		4 / 7TRP A 393
SER A 550
GLY A 196
LEU A 560
None
0.98A21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		1imv PIGMENT
EPITHELIUM-DERIVED
FACTOR
(Homo
sapiens)		4 / 7SER A  61
SER A  64
GLY A 189
LEU A 116
None
1.14A23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		1itu RENAL DIPEPTIDASE
(Homo
sapiens)		4 / 7TRP A  25
SER A  66
HIS A 152
GLY A 126
CIL  A 451 ( 4.4A)
ZN  A 401 ( 3.7A)
CIL  A 451 (-4.0A)
None
1.03A21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		1qgr PROTEIN (IMPORTIN
BETA SUBUNIT)
(Homo
sapiens)		4 / 7HIS A 803
GLY A 806
ARG A 762
LEU A 758
None
1.03A19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		2gy7 ANGIOPOIETIN-2
(Homo
sapiens)		4 / 7SER A 415
SER A 385
GLY A 408
LEU A 375
None
1.07A18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		2iuw ALKYLATED REPAIR
PROTEIN ALKB HOMOLOG
3
(Homo
sapiens)		4 / 7SER A 206
SER A 208
GLY A 242
ARG A 269
AKG  A 700 ( 4.1A)
AKG  A 700 ( 4.8A)
None
AKG  A 700 (-2.9A)
1.05A19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		2qna IMPORTIN SUBUNIT
BETA-1
(Homo
sapiens)		4 / 7HIS A 803
GLY A 806
ARG A 762
LEU A 758
None
1.07A20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		3btz ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB
HOMOLOG 2
(Homo
sapiens)		4 / 7SER A 186
SER A 188
GLY A 221
ARG A 248
None
0.90A19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		3d3j ENHANCER OF
MRNA-DECAPPING
PROTEIN 3
(Homo
sapiens)		4 / 7SER A 352
HIS A 356
GLY A 309
ARG A 355
None
1.12A22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		3d3k ENHANCER OF
MRNA-DECAPPING
PROTEIN 3
(Homo
sapiens)		4 / 7SER A 352
HIS A 356
GLY A 309
LEU A 384
None
0.72A20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		4dyo ASPARTYL
AMINOPEPTIDASE
(Homo
sapiens)		4 / 7SER A 268
SER A 434
GLY A 450
LEU A 432
None
1.09A23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens)		4 / 7SER A 230
HIS A 222
GLY A 202
LEU A 104
None
1.12A20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		4nrq RNA DEMETHYLASE
ALKBH5
(Homo
sapiens)		4 / 7SER A 217
SER A 219
GLY A 251
ARG A 277
PD2  A 301 ( 4.9A)
PD2  A 301 ( 4.5A)
None
PD2  A 301 (-2.7A)
1.08A19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		4uta BROADLY NEUTRALIZING
HUMAN ANTIBODY EDE1
C8 HEAVY CHAIN
(Homo
sapiens)		4 / 7SER H 101
SER H  33
HIS H  35
GLY H  98
None
0.86A21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		5ajz 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3
(Homo
sapiens)		4 / 7SER A 437
HIS A 253
GLY A 254
ARG A 252
None
PHS  A1446 (-3.4A)
None
PHS  A1446 (-3.5A)
1.16A20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1
(Homo
sapiens)		4 / 7TRP A 349
SER A 405
HIS A 472
GLY A 471
None
1.15A23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens)		4 / 7TRP B 527
SER B 602
GLY B 503
ARG B 601
None
SO4  B 909 (-2.2A)
None
SO4  B 909 (-3.8A)
1.06A21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		5lbs BROADLY NEUTRALIZING
HUMAN ANTIBODY EDE1
C8
(Homo
sapiens)		4 / 7SER H  97
SER H  33
HIS H  35
GLY H  94
None
0.84A16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		5viy BG1 FAB HEAVY CHAIN
(Homo
sapiens)		4 / 7SER H  23
SER H   7
GLY H   8
ARG H 125
None
1.12A19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10
(Homo
sapiens)		4 / 7SER A 436
SER A 391
HIS A 387
GLY A 386
None
None
ZN  A 705 (-4.0A)
None
1.15Aundetectable