POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		1tf0 SERUM ALBUMIN
(Homo
sapiens)		10 / 12ILE A 388
ASN A 391
PHE A 403
LEU A 407
TYR A 411
LEU A 430
VAL A 433
GLU A 450
LEU A 453
ARG A 485
None
0.85A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		1ysx SERUM ALBUMIN
(Homo
sapiens)		6 / 12ILE A 388
ASN A 391
CYH A 392
PHE A 403
LEU A 407
TYR A 411
4EB  A1000 ( 4.6A)
4EB  A1000 (-3.5A)
4EB  A1000 (-3.2A)
4EB  A1000 ( 4.1A)
4EB  A1000 (-4.5A)
4EB  A1000 (-3.3A)
1.03A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		1z68 FIBROBLAST
ACTIVATION PROTEIN,
ALPHA SUBUNIT
(Homo
sapiens)		5 / 12ILE A 367
ASN A 399
PHE A 401
TYR A 450
GLU A 396
None
1.05A22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		2v0o FCH DOMAIN ONLY
PROTEIN 2
(Homo
sapiens)		5 / 12ILE A 227
LEU A  97
GLU A  46
LEU A  94
ARG A  42
None
1.22A18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		3d9h CDNA FLJ77766,
HIGHLY SIMILAR TO
HOMO SAPIENS ANKYRIN
REPEAT AND SOCS
BOX-CONTAINING 9
(ASB9), TRANSCRIPT
VARIANT 2, MRNA
(Homo
sapiens)		5 / 12LEU A 171
VAL A 206
GLU A 213
LEU A 214
ARG A 180
None
1.23A18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		3lb6 INTERLEUKIN-13
RECEPTOR SUBUNIT
ALPHA-2
(Homo
sapiens)		5 / 12PHE D 246
LEU D 256
TYR D 293
LEU D 295
LEU D 283
None
1.23A18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		4qdv M7GPPPX
DIPHOSPHATASE
(Homo
sapiens)		5 / 12ILE A 244
TYR A 312
LEU A 230
CYH A 222
LEU A 267
None
PO4  A 403 (-4.5A)
None
None
None
1.20A20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		5for PHOSPHOINOSITIDE
3-KINASE ADAPTER
PROTEIN 1
(Homo
sapiens)		5 / 12LEU A 121
LEU A  98
VAL A  65
CYH A  63
LEU A  24
None
1.00A13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		5fwj HISTONE DEMETHYLASE
JARID1C
(Homo
sapiens)		5 / 12ILE A 515
LEU A 576
VAL A 537
GLU A 546
LEU A 545
None
1.21A20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens)		5 / 12LEU A 499
LEU A 469
VAL A 505
GLU A 479
LEU A 478
None
1.20A22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		5la7 HEPARANASE
(Homo
sapiens)		5 / 12PHE A 386
LEU A  65
LEU A  72
GLU A 113
ARG A  70
None
1.16A22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		5t3p PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7
(Homo
sapiens)		5 / 12PHE A  74
LEU A  56
LEU A  47
VAL A 126
LEU A  24
None
1.15A17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		5v9p LYSINE-SPECIFIC
DEMETHYLASE 5A
(Homo
sapiens)		5 / 12ILE A 484
LEU A 545
VAL A 506
GLU A 515
LEU A 514
None
1.12A22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		5vxc CITRATE LYASE
SUBUNIT BETA-LIKE
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens)		5 / 12LEU A 166
LEU A 133
VAL A 108
GLU A 117
LEU A 120
None
1.15A19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		5wrj PROTEIN-TYROSINE
SULFOTRANSFERASE 1
(Homo
sapiens)		5 / 12ILE A 145
PHE A  73
LEU A 170
TYR A 169
LEU A 173
None
1.21A20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		5yax SCFV1 ANTIBODY
(Homo
sapiens)		5 / 12TYR A1102
LEU A1124
VAL A1126
LEU A1094
ARG A1075
None
1.23A14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		1d6v CHIMERIC GERMLINE
PRECURSOR OF
OXY-COPE CATALYTIC
ANTIBODY AZ-28
(LIGHT CHAIN)
(Homo
sapiens;
Mus
musculus)		5 / 12TYR L  86
LEU L 104
GLU L  79
LEU L  78
ARG L  61
None
None
CD  L 501 (-2.4A)
None
CD  L 504 ( 4.3A)
1.33A14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		1jm7 BREAST CANCER TYPE 1
SUSCEPTIBILITY
PROTEIN
(Homo
sapiens)		5 / 12ILE A  21
LEU A  87
VAL A  83
GLU A  23
LEU A  30
None
1.33A11.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		1tf0 SERUM ALBUMIN
(Homo
sapiens)		9 / 12ILE A 388
ASN A 391
PHE A 403
TYR A 411
LEU A 430
VAL A 433
GLU A 450
LEU A 453
ARG A 485
None
0.87A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		1tf0 SERUM ALBUMIN
(Homo
sapiens)		6 / 12LEU A 387
ILE A 388
ASN A 391
PHE A 403
GLU A 450
ARG A 485
None
0.93A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		1ysx SERUM ALBUMIN
(Homo
sapiens)		5 / 12ILE A 388
ASN A 391
CYH A 392
PHE A 403
TYR A 411
4EB  A1000 ( 4.6A)
4EB  A1000 (-3.5A)
4EB  A1000 (-3.2A)
4EB  A1000 ( 4.1A)
4EB  A1000 (-3.3A)
0.81A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		1ysx SERUM ALBUMIN
(Homo
sapiens)		5 / 12LEU A 387
ASN A 391
CYH A 392
PHE A 403
TYR A 411
None
4EB  A1000 (-3.5A)
4EB  A1000 (-3.2A)
4EB  A1000 ( 4.1A)
4EB  A1000 (-3.3A)
0.93A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		1z68 FIBROBLAST
ACTIVATION PROTEIN,
ALPHA SUBUNIT
(Homo
sapiens)		5 / 12ILE A 367
ASN A 399
PHE A 401
TYR A 450
GLU A 396
None
1.10A22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		2cd0 PROTEIN (BENCE-JONES
PROTEIN WIL, A
VARIABLE DOMAIN FROM
LAMBDA-6 TYPE
IMMUNOGLOBULIN LIGHT
CHAIN)
(Homo
sapiens)		5 / 12TYR A  86
LEU A 104
VAL A 106
LEU A  78
ARG A  61
None
1.21A10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		2nym SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens)		5 / 12LEU C 170
ILE C 174
LEU C 158
VAL C  45
LEU C 177
None
1.22A18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		2v0o FCH DOMAIN ONLY
PROTEIN 2
(Homo
sapiens)		5 / 12ILE A 227
LEU A  97
GLU A  46
LEU A  94
ARG A  42
None
1.22A18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		3tlp PROTEIN POLYBROMO-1
(Homo
sapiens)		5 / 12LEU A 494
VAL A 498
CYH A 511
GLU A 583
LEU A 586
None
1.20A14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		3x1o ROQUIN-1
(Homo
sapiens)		5 / 12LEU A 307
LEU A 249
VAL A 245
LEU A 204
ARG A 280
None
1.34A16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		4buh CLONE M0418 SCFV
(Homo
sapiens)		5 / 12TYR A 228
LEU A 248
VAL A 250
LEU A 220
ARG A 203
None
1.33A16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1
(Homo
sapiens)		5 / 12ILE A 780
CYH A 772
LEU A 839
VAL A 836
LEU A 743
None
1.27A20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		4iqh DYSFERLIN
(Homo
sapiens)		5 / 12LEU A  94
PHE A 103
LEU A  67
VAL A 123
LEU A   3
None
1.34A14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		4kq8 CYTOCHROME P450 19A1
(Homo
sapiens)		5 / 12ILE A 132
ASN A 135
LEU A 122
CYH A 299
ARG A 115
HEM  A 601 (-3.8A)
None
None
None
HEM  A 601 ( 2.6A)
1.31A21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		4m4z SRC-LIKE-ADAPTER 2
(Homo
sapiens)		5 / 12LEU A 110
ASN A 113
TYR A  96
LEU A 119
GLU A 106
None
1.33A14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		4qik ROQUIN-1
(Homo
sapiens)		5 / 12LEU A 307
LEU A 249
VAL A 245
LEU A 204
ARG A 280
None
1.33A22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		4z31 ROQUIN-2
(Homo
sapiens)		5 / 12LEU A 304
LEU A 246
VAL A 242
LEU A 201
ARG A 277
None
1.32A20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		4zlc ROQUIN-2
(Homo
sapiens)		5 / 12LEU A 304
LEU A 246
VAL A 242
LEU A 201
ARG A 277
None
1.29A13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		5fwj HISTONE DEMETHYLASE
JARID1C
(Homo
sapiens)		5 / 12ILE A 515
LEU A 576
VAL A 537
GLU A 546
LEU A 545
None
1.21A20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		5l2x DNA-DIRECTED
PRIMASE/POLYMERASE
PROTEIN
(Homo
sapiens)		5 / 12LEU A 134
ILE A 135
CYH A 139
TYR A 284
CYH A 150
None
0.83A20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		5v9p LYSINE-SPECIFIC
DEMETHYLASE 5A
(Homo
sapiens)		5 / 12ILE A 484
LEU A 545
VAL A 506
GLU A 515
LEU A 514
None
1.12A22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		5yax SCFV1 ANTIBODY
(Homo
sapiens)		5 / 12TYR A1102
LEU A1124
VAL A1126
LEU A1094
ARG A1075
None
1.18A14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		6bgz LYSINE-SPECIFIC
DEMETHYLASE 5A,
LINKED KDM5A JMJ
DOMAIN
(Homo
sapiens)		5 / 12ILE A 484
LEU A 545
VAL A 506
GLU A 515
LEU A 514
None
1.26A7.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		6ek6 LYSINE-SPECIFIC
DEMETHYLASE
5B,LYSINE-SPECIFIC
DEMETHYLASE 5B
(Homo
sapiens)		5 / 12ILE A 500
LEU A 561
VAL A 522
GLU A 531
LEU A 530
DMS  A 805 (-4.9A)
None
None
DMS  A 805 ( 4.6A)
None
1.30A7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_B_DZPB502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		1by8 PROTEIN
(PROCATHEPSIN K)
(Homo
sapiens)		5 / 11ILE A  42
LEU A  39
MET A  66
THR A  67
LEU A  63
None
1.19A13.67
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_B_DZPB502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		1zq9 PROBABLE
DIMETHYLADENOSINE
TRANSFERASE
(Homo
sapiens)		5 / 11LEU A  39
MET A  70
THR A  71
LEU A 153
MET A 154
None
1.49A13.38
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_B_DZPB502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		3ut3 PLASMINOGEN
ACTIVATOR INHIBITOR
1
(Homo
sapiens)		5 / 11ILE A  66
LEU A  48
THR A 307
MET A 298
THR A  54
None
1.39A13.98
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_B_DZPB502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		4bc5 XYLULOSE KINASE
(Homo
sapiens)		5 / 11ILE A 436
LEU A 437
THR A 304
LEU A 307
PHE A 306
None
1.21A11.36
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_B_DZPB502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct)		5 / 11ILE A4284
LEU A4269
PRO A4270
LEU A4304
PHE A4303
None
1.25A2.16
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_B_DZPB502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		5k47 POLYCYSTIN-2
(Homo
sapiens)		5 / 11ILE A 236
LEU A 237
THR A 565
LEU A 229
PHE A 230
None
1.43A10.29
8.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HUP_B_DZPB502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		6d6u GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-2,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT BETA-2
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
(Homo
sapiens;
Homo
sapiens)		6 / 11ILE B 228
LEU B 232
PRO B 233
MET B 236
THR B 237
THR A 262
None
0.82A100.00
28.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HUP_B_DZPB502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		6d6u GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-2,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT BETA-2
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
(Homo
sapiens;
Homo
sapiens)		6 / 11ILE B 228
LEU B 232
PRO B 233
THR B 237
THR A 262
ASN A 265
None
0.94A100.00
28.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HUP_B_DZPB502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		6d6u GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-2,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT BETA-2
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
(Homo
sapiens;
Homo
sapiens)		6 / 11ILE B 228
LEU B 232
PRO B 233
THR B 237
THR A 262
LEU A 285
None
1.31A100.00
28.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HUP_B_DZPB502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		6d6u GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-2,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT BETA-2
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
(Homo
sapiens;
Homo
sapiens)		6 / 11ILE B 228
LEU B 232
PRO B 233
THR B 237
THR A 266
LEU A 285
None
1.04A100.00
28.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HUP_B_DZPB502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		6d6u GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-2,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT BETA-2
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
(Homo
sapiens;
Homo
sapiens)		6 / 11ILE B 228
PRO B 233
THR B 237
THR A 262
ASN A 265
PHE A 289
None
1.26A100.00
28.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HUP_B_DZPB502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		6d6u GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-2,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT BETA-2
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
(Homo
sapiens;
Homo
sapiens)		6 / 11ILE B 228
PRO B 233
THR B 237
THR A 262
LEU A 285
PHE A 289
None
1.35A100.00
28.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HUP_B_DZPB502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		6d6u GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-2,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT BETA-2
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
(Homo
sapiens;
Homo
sapiens)		6 / 11ILE B 228
THR B 237
MET A 261
THR A 262
ASN A 265
PHE A 289
None
1.28A100.00
28.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HUP_B_DZPB502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		6d6u GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-2,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT BETA-2
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
(Homo
sapiens;
Homo
sapiens)		6 / 11ILE B 228
THR B 237
MET A 261
THR A 262
LEU A 285
PHE A 289
None
1.34A100.00
28.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HUP_B_DZPB502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		6d6u GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-2,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT BETA-2
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
(Homo
sapiens;
Homo
sapiens)		5 / 11PRO B 233
THR B 237
THR A 266
LEU A 285
MET A 286
None
1.14A100.00
28.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_D_DZPD2001_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		2ad1 SULFOTRANSFERASE 1C2
(Homo
sapiens)		5 / 9TYR A  47
ASN A 136
PHE A 277
TYR A 281
SER A 172
None
1.50A13.99
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_D_DZPD2001_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		2j3t TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 1
TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 4
(Mus
musculus;
Homo
sapiens)		5 / 9PHE D 142
PHE C  48
VAL D 156
SER D   5
TYR D   7
None
1.13A16.13
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_D_DZPD2001_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		6d6u GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
(Homo
sapiens)		5 / 9PHE B 100
HIS B 102
TYR B 160
VAL B 203
TYR B 210
None
0.65A20.22
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_D_DZPD2001_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		6d6u GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
(Homo
sapiens)		5 / 9PHE B 100
TYR B 160
VAL B 203
SER B 205
TYR B 210
None
0.87A20.22
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_E_DZPE502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		1jmo HEPARIN COFACTOR II
(Homo
sapiens)		5 / 10LEU A 468
LEU A 186
MET A 143
THR A 141
LEU A 162
None
1.38A10.87
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_E_DZPE502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		1w98 G1/S-SPECIFIC CYCLIN
E1
(Homo
sapiens)		5 / 10PRO B  89
LEU B  90
MET B 239
LEU B 289
MET B 298
None
1.44A14.08
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_E_DZPE502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
(Homo
sapiens)		5 / 10LEU A2016
LEU A1963
THR A2022
ASN A2021
MET A2063
None
1.42A7.98
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_E_DZPE502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
(Homo
sapiens)		5 / 10LEU A2016
LEU A1963
THR A2022
ASN A2021
PHE A2023
None
1.15A7.98
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_E_DZPE502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		5fu7 CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
(Homo
sapiens)		5 / 10LEU A2016
LEU A1963
THR A2022
ASN A2021
PHE A2023
None
1.18A11.88
9.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HUP_E_DZPE502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		6d6u GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-2,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT BETA-2
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
(Homo
sapiens;
Homo
sapiens)		6 / 10LEU B 232
PRO B 233
LEU B 269
THR A 266
LEU A 285
MET A 286
None
1.23A100.00
28.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HUP_E_DZPE502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		6d6u GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-2,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT BETA-2
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
(Homo
sapiens;
Homo
sapiens)		6 / 10LEU B 232
PRO B 233
MET A 261
ASN A 265
LEU A 285
MET A 286
None
1.35A100.00
28.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HUP_E_DZPE502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		6d6u GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-2,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT BETA-2
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
(Homo
sapiens;
Homo
sapiens)		7 / 10LEU B 232
PRO B 233
MET A 261
THR A 262
ASN A 265
LEU A 285
PHE A 289
None
1.00A100.00
28.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HUP_E_DZPE502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		6d6u GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-2,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT BETA-2
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
(Homo
sapiens;
Homo
sapiens)		5 / 10LEU B 232
PRO B 233
MET B 236
ASN A 265
MET A 286
None
1.26A100.00
28.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HUP_E_DZPE502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		6d6u GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-2,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT BETA-2
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
(Homo
sapiens;
Homo
sapiens)		5 / 10LEU B 232
PRO B 233
MET B 236
LEU B 269
MET A 286
None
1.31A100.00
28.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HUP_E_DZPE502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		6d6u GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-2,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT BETA-2
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
(Homo
sapiens;
Homo
sapiens)		6 / 10LEU B 232
PRO B 233
MET B 236
THR A 262
ASN A 265
PHE A 289
None
1.13A100.00
28.75