POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O7O_A_DXTA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		1ck7 PROTEIN (GELATINASE
A)
(Homo
sapiens)		5 / 12SER A 246
HIS A 276
PRO A 275
VAL A 221
GLN A 219
None
1.34A15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O7O_A_DXTA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		3kg5 B-CELL ANTIGEN
RECEPTOR
COMPLEX-ASSOCIATED
PROTEIN BETA CHAIN
(Homo
sapiens)		5 / 12SER A  69
ASN A  68
VAL A  74
GLN A 124
ILE A  46
None
1.41A19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O7O_A_DXTA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens)		5 / 12HIS A 167
SER A 163
HIS A 148
THR A 161
ILE A 178
None
1.49A19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O7O_A_DXTA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		5uen ADENOSINE RECEPTOR
A1,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A1
(Escherichia
coli;
Homo
sapiens)		5 / 12HIS A 251
ASN A 184
THR A  91
VAL A  87
ILE A 175
None
None
DU1  A1201 (-3.7A)
DU1  A1201 (-4.7A)
None
1.42A20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O7O_A_DXTA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		5uke INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 3
(Homo
sapiens)		5 / 12SER A  17
ASN A 109
PRO A 116
THR A  20
ILE A  88
None
1.36A18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		1bhq CD11B
(Homo
sapiens)		5 / 12ASN 1 310
THR 1 159
VAL 1 160
GLN 1 163
LEU 1 164
None
1.37A21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		1fsu N-ACETYLGALACTOSAMIN
E-4-SULFATASE
(Homo
sapiens)		5 / 12SER A 428
ASN A 426
THR A 471
LEU A 440
SER A 423
NAG  A 602 ( 4.7A)
NAG  A 602 (-2.0A)
None
None
None
1.35A18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		2jgz G2/MITOTIC-SPECIFIC
CYCLIN-B1
(Homo
sapiens)		5 / 12SER B 413
VAL B 387
GLN B 417
LEU B 422
ILE B 355
None
1.24A22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		2ohf GTP-BINDING PROTEIN
9
(Homo
sapiens)		5 / 12SER A  62
PHE A  87
THR A  43
LEU A 292
ILE A 296
None
1.25A21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		2okj GLUTAMATE
DECARBOXYLASE 1
(Homo
sapiens)		5 / 12ASN A 256
PRO A 403
LEU A 417
ILE A 416
SER A 249
LLP  A 405 ( 4.6A)
None
None
None
None
1.31A17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		2oz4 INTERCELLULAR
ADHESION MOLECULE 1
(Homo
sapiens)		5 / 12PRO A 197
THR A 277
VAL A 278
LEU A 227
ILE A 280
None
1.34A22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2
(Homo
sapiens)		5 / 12ASN A  33
THR A  92
VAL A  93
GLN A  96
LEU A  97
None
0.94A15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		4b3g DNA-BINDING PROTEIN
SMUBP-2
(Homo
sapiens)		5 / 12SER A 582
ASN A 511
THR A 616
VAL A 617
LEU A 591
None
1.45A17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		4da1 PROTEIN PHOSPHATASE
1K, MITOCHONDRIAL
(Homo
sapiens)		5 / 12SER A 209
ASN A 301
THR A 191
LEU A 222
ILE A 212
None
1.28A20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		5fwj HISTONE DEMETHYLASE
JARID1C
(Homo
sapiens)		5 / 12SER A 472
HIS A 527
PRO A  55
LEU A 462
SER A 451
None
1.48A17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens)		5 / 12SER A1625
ASN A1699
LEU A1619
ILE A1641
SER A1554
None
1.41A3.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		5u1d ANTIGEN PEPTIDE
TRANSPORTER 1
ANTIGEN PEPTIDE
TRANSPORTER 2
(Homo
sapiens)		5 / 12SER B 254
THR B 258
LEU B 223
ILE A 397
SER A 359
None
1.50A17.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		1as4 ANTICHYMOTRYPSIN
(Homo
sapiens)		5 / 9VAL A  31
LEU A 272
ASP A 277
VAL B 375
ILE B 382
None
0.40A98.08
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		1gul GLUTATHIONE
TRANSFERASE A4-4
(Homo
sapiens)		5 / 9VAL A  96
LEU A  72
ASP A  77
VAL A 158
ILE A 159
None
1.09A16.28
12.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		1qmn ALPHA-1-ANTICHYMOTRY
PSIN
(Homo
sapiens)		5 / 9VAL A  31
LEU A 272
ASP A 277
VAL A 379
ILE A 386
None
0.52A85.00
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens)		5 / 9LEU A 429
ALA A 430
PHE A 433
VAL A 598
ILE A 482
None
1.03A8.06
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens)		5 / 9VAL A 405
LEU A 429
ALA A 430
PHE A 433
ILE A 482
None
1.10A8.06
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		3juy 3B3 SINGLE CHAIN
VARIANT HIV-1
ANTIBODY
(Homo
sapiens)		5 / 9LEU B 247
ALA B 227
PHE B 226
VAL B 221
ILE B 218
None
1.21A16.13
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		4h1s 5'-NUCLEOTIDASE
(Homo
sapiens)		5 / 9LEU A 127
PHE A 120
ASP A 121
HIS A 220
ILE A 139
None
None
None
ZN  A 602 (-3.3A)
None
1.21A9.25
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		4r7v ARRESTIN
DOMAIN-CONTAINING
PROTEIN 3
(Homo
sapiens)		5 / 9VAL A   6
LEU A  36
VAL A  44
HIS A 143
ILE A  42
None
0.86A17.61
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		4r7x ARRESTIN
DOMAIN-CONTAINING
PROTEIN 3
(Homo
sapiens)		5 / 9VAL A   6
LEU A  36
VAL A  44
HIS A 143
ILE A  42
None
None
None
PO4  A 204 ( 3.9A)
None
0.74A17.93
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		4ui9 CELL DIVISION CYCLE
PROTEIN 23 HOMOLOG
(Homo
sapiens)		5 / 9LEU C 405
ALA C 401
ASP C 398
HIS C 390
ILE C 385
None
1.16A9.20
6.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		4xny LIGHT CHAIN OF
ANTIBODY VRC08C
(Homo
sapiens)		5 / 9LEU L 104
ALA L  84
PHE L  83
VAL L  78
ILE L  75
None
1.21A15.76
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB7
(Homo
sapiens)		5 / 9VAL G  26
LEU G  22
PHE G  18
VAL G  66
HIS G  14
None
1.17A18.75
17.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		1as4 ANTICHYMOTRYPSIN
(Homo
sapiens)		4 / 6LEU A  37
SER A  36
PHE A  33
ASP A  32
None
1.09A98.08
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		1kgd PERIPHERAL PLASMA
MEMBRANE CASK
(Homo
sapiens)		4 / 6LEU A 740
PHE A 885
ASP A 886
HIS A 883
None
1.23A20.71
12.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		1qmn ALPHA-1-ANTICHYMOTRY
PSIN
(Homo
sapiens)		4 / 6LEU A  37
SER A  36
PHE A  33
ASP A  32
None
1.09A85.00
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		1u6g TIP120 PROTEIN
(Homo
sapiens)		4 / 6LEU C 752
SER C 753
ASP C 757
HIS C 848
None
0.77A5.34
2.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		1z7c CHORIONIC
SOMATOMAMMOTROPIN
HORMONE
(Homo
sapiens)		4 / 6LEU A   6
SER A   7
PHE A  10
ASP A  11
None
0.70A18.54
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		2ad1 SULFOTRANSFERASE 1C2
(Homo
sapiens)		4 / 6LEU A 119
SER A 118
PHE A  35
HIS A  98
None
1.00A14.18
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		2ce9 TRANSDUCIN-LIKE
ENHANCER PROTEIN 1
(Homo
sapiens)		4 / 6LEU A 722
SER A 736
PHE A 734
HIS A 474
None
1.04A12.00
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		3cos ALCOHOL
DEHYDROGENASE 4
(Homo
sapiens)		4 / 6LEU A  22
PHE A 365
ASP A 366
HIS A  48
None
None
None
NAD  A 400 (-3.8A)
1.10A10.90
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		3hhr HUMAN GROWTH HORMONE
(Homo
sapiens)		4 / 6LEU A   6
SER A   7
PHE A  10
ASP A  11
None
0.72A19.21
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		4bwe GLYPICAN-1
(Homo
sapiens)		4 / 6LEU A 396
SER A 395
PHE A 392
ASP A 391
None
None
None
CA  A 503 (-2.5A)
1.06A12.25
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		4cq1 POLYPYRIMIDINE
TRACT-BINDING
PROTEIN 2
(Homo
sapiens)		4 / 6LEU A 508
SER A 525
PHE A 526
HIS A 394
None
1.02A19.31
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		4h1s 5'-NUCLEOTIDASE
(Homo
sapiens)		4 / 6LEU A 127
PHE A 120
ASP A 121
HIS A 220
None
None
None
ZN  A 602 (-3.3A)
1.14A9.25
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		4jif INTEGRIN
BETA-1-BINDING
PROTEIN 1
(Homo
sapiens)		4 / 6LEU A 187
SER A 188
PHE A 191
ASP A 192
None
0.55A18.83
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens)		4 / 6LEU A 256
SER A 257
ASP A 261
HIS A 118
None
1.09A15.30
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		4nge PRESEQUENCE
PROTEASE,
MITOCHONDRIAL
(Homo
sapiens)		4 / 6LEU D 447
PHE D 443
ASP D  83
HIS D 438
None
1.12A7.25
4.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct)		4 / 6LEU A1921
PHE A1918
ASP A1914
TRP A1864
None
1.17A2.41
1.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		5eo3 PROTEIN PELOTA
HOMOLOG
(Homo
sapiens)		4 / 6SER A 314
PHE A 346
ASP A 315
HIS A 350
None
1.01A25.42
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		5l3d LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1A
(Homo
sapiens)		4 / 6LEU A 392
SER A 393
PHE A 398
ASP A 397
None
1.17A6.59
3.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		5zcs TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8
(Homo
sapiens)		4 / 6LEU C 199
SER C 183
ASP C 181
HIS C 177
None
1.22A18.39
16.05