POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M2Z_A_DEXA301_1
(GLUCOCORTICOID
RECEPTOR)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		6 / 12ASN A 705
GLY A 708
GLN A 711
MET A 742
ARG A 752
PHE A 891
BHM  A   1 (-3.6A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
None
0.87A48.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M2Z_A_DEXA301_1
(GLUCOCORTICOID
RECEPTOR)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		5 / 12GLY A 708
GLN A 711
MET A 742
ARG A 752
MET A 787
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
BHM  A   1 (-3.6A)
0.92A48.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M2Z_A_DEXA301_1
(GLUCOCORTICOID
RECEPTOR)		2bzn GMP REDUCTASE 2
(Homo
sapiens)		5 / 12MET A 269
GLY A 183
MET A 240
THR A  57
PHE A 266
None
IMP  A1338 (-3.4A)
IMP  A1338 (-3.5A)
None
None
1.41A19.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M2Z_A_DEXA301_1
(GLUCOCORTICOID
RECEPTOR)		3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)		8 / 12ASN A 719
GLY A 722
MET A 756
ARG A 766
MET A 801
CYH A 891
THR A 894
PHE A 905
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.5A)
WOW  A   1 (-3.9A)
WOW  A   1 (-4.6A)
0.70A53.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M2Z_A_DEXA301_1
(GLUCOCORTICOID
RECEPTOR)		3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)		7 / 12ASN A 719
TRP A 755
MET A 756
MET A 801
CYH A 891
THR A 894
PHE A 905
WOW  A   1 (-3.3A)
None
WOW  A   1 ( 4.1A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.5A)
WOW  A   1 (-3.9A)
WOW  A   1 (-4.6A)
1.14A53.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M2Z_A_DEXA301_1
(GLUCOCORTICOID
RECEPTOR)		3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)		7 / 12GLY A 722
GLN A 725
MET A 756
ARG A 766
MET A 801
CYH A 891
THR A 894
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.5A)
WOW  A   1 (-3.9A)
0.79A53.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M2Z_A_DEXA301_1
(GLUCOCORTICOID
RECEPTOR)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		9 / 12ASN A 564
GLY A 568
GLN A 570
TRP A 600
MET A 601
CYH A 736
THR A 739
PHE A 749
LEU A 753
MOF  A 801 (-3.0A)
None
MOF  A 801 (-2.9A)
None
MOF  A 801 (-3.7A)
MOF  A 801 (-3.7A)
MOF  A 801 (-3.9A)
MOF  A 801 (-4.4A)
None
0.96A97.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M2Z_A_DEXA301_1
(GLUCOCORTICOID
RECEPTOR)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		12 / 12MET A 560
ASN A 564
GLY A 567
GLN A 570
TRP A 600
MET A 601
ARG A 611
MET A 646
CYH A 736
THR A 739
PHE A 749
LEU A 753
MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
None
MOF  A 801 (-3.7A)
MOF  A 801 (-4.2A)
MOF  A 801 (-4.4A)
MOF  A 801 (-3.7A)
MOF  A 801 (-3.9A)
MOF  A 801 (-4.4A)
None
0.42A97.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M2Z_A_DEXA301_1
(GLUCOCORTICOID
RECEPTOR)		4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		9 / 12ASN A 770
GLN A 776
TRP A 806
MET A 807
ARG A 817
CYH A 942
THR A 945
PHE A 956
LEU A 960
CV7  A1987 (-3.1A)
CV7  A1987 (-3.0A)
None
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
CV7  A1987 (-4.0A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.7A)
None
0.44A52.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M2Z_A_DEXA301_1
(GLUCOCORTICOID
RECEPTOR)		4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		9 / 12ASN A 770
GLN A 776
TRP A 806
MET A 807
ARG A 817
MET A 852
CYH A 942
THR A 945
LEU A 960
CV7  A1987 (-3.1A)
CV7  A1987 (-3.0A)
None
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.7A)
CV7  A1987 (-4.0A)
CV7  A1987 (-3.1A)
None
0.68A52.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M2Z_A_DEXA301_1
(GLUCOCORTICOID
RECEPTOR)		4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		8 / 12ASN A 770
GLY A 774
GLN A 776
TRP A 806
CYH A 942
THR A 945
PHE A 956
LEU A 960
CV7  A1987 (-3.1A)
None
CV7  A1987 (-3.0A)
None
CV7  A1987 (-4.0A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.7A)
None
1.10A52.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M2Z_A_DEXA301_1
(GLUCOCORTICOID
RECEPTOR)		5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		9 / 12ASN A 770
GLN A 776
TRP A 806
MET A 807
ARG A 817
CYH A 942
THR A 945
PHE A 956
LEU A 960
ECV  A1101 (-3.1A)
ECV  A1101 (-2.9A)
None
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
ECV  A1101 ( 4.7A)
None
0.52A45.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M2Z_A_DEXA301_1
(GLUCOCORTICOID
RECEPTOR)		5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		8 / 12ASN A 770
GLY A 774
GLN A 776
TRP A 806
CYH A 942
THR A 945
PHE A 956
LEU A 960
ECV  A1101 (-3.1A)
None
ECV  A1101 (-2.9A)
None
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
ECV  A1101 ( 4.7A)
None
1.10A45.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M2Z_A_DEXA301_1
(GLUCOCORTICOID
RECEPTOR)		5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		5 / 12GLN A 776
TRP A 806
MET A 807
ARG A 817
MET A 852
ECV  A1101 (-2.9A)
None
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.7A)
1.27A45.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M2Z_D_DEXD401_1
(GLUCOCORTICOID
RECEPTOR)		1d1j PROFILIN II
(Homo
sapiens)		5 / 12ASN A  99
GLY A 114
GLN A  17
ILE A  73
LEU A 123
SO4  A 800 (-3.1A)
None
None
None
None
1.43A19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M2Z_D_DEXD401_1
(GLUCOCORTICOID
RECEPTOR)		1htr GASTRICSIN
PROGASTRICSIN (PRO
SEGMENT)
(Homo
sapiens)		5 / 12MET B  10
GLY B 219
ILE P  13
PHE B 117
LEU B  30
None
1.06A21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M2Z_D_DEXD401_1
(GLUCOCORTICOID
RECEPTOR)		1mi1 NEUROBEACHIN
(Homo
sapiens)		5 / 12ASN A2393
GLY A2395
THR A2403
PHE A2389
LEU A2390
None
1.28A20.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M2Z_D_DEXD401_1
(GLUCOCORTICOID
RECEPTOR)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		6 / 12ASN A 705
GLY A 708
GLN A 711
MET A 742
ARG A 752
PHE A 891
BHM  A   1 (-3.6A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
None
0.80A48.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M2Z_D_DEXD401_1
(GLUCOCORTICOID
RECEPTOR)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		5 / 12GLY A 708
GLN A 711
MET A 742
ARG A 752
MET A 787
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
BHM  A   1 (-3.6A)
0.95A48.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M2Z_D_DEXD401_1
(GLUCOCORTICOID
RECEPTOR)		3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)		8 / 12ASN A 719
GLY A 722
MET A 756
ARG A 766
MET A 801
CYH A 891
THR A 894
PHE A 905
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.5A)
WOW  A   1 (-3.9A)
WOW  A   1 (-4.6A)
0.70A53.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M2Z_D_DEXD401_1
(GLUCOCORTICOID
RECEPTOR)		3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)		6 / 12GLY A 722
GLN A 725
MET A 756
ARG A 766
MET A 801
CYH A 891
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.5A)
0.86A53.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M2Z_D_DEXD401_1
(GLUCOCORTICOID
RECEPTOR)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		9 / 12ASN A 564
GLY A 568
GLN A 570
MET A 601
CYH A 736
THR A 739
ILE A 747
PHE A 749
LEU A 753
MOF  A 801 (-3.0A)
None
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 (-3.7A)
MOF  A 801 (-3.9A)
MOF  A 801 ( 4.4A)
MOF  A 801 (-4.4A)
None
0.94A97.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M2Z_D_DEXD401_1
(GLUCOCORTICOID
RECEPTOR)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		12 / 12MET A 560
ASN A 564
GLY A 567
GLN A 570
MET A 601
ARG A 611
MET A 646
CYH A 736
THR A 739
ILE A 747
PHE A 749
LEU A 753
MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.2A)
MOF  A 801 (-4.4A)
MOF  A 801 (-3.7A)
MOF  A 801 (-3.9A)
MOF  A 801 ( 4.4A)
MOF  A 801 (-4.4A)
None
0.40A97.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M2Z_D_DEXD401_1
(GLUCOCORTICOID
RECEPTOR)		4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		8 / 12ASN A 770
GLN A 776
MET A 807
ARG A 817
CYH A 942
THR A 945
PHE A 956
LEU A 960
CV7  A1987 (-3.1A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
CV7  A1987 (-4.0A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.7A)
None
0.39A52.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M2Z_D_DEXD401_1
(GLUCOCORTICOID
RECEPTOR)		4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		7 / 12ASN A 770
GLN A 776
MET A 807
ARG A 817
MET A 852
CYH A 942
THR A 945
CV7  A1987 (-3.1A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.7A)
CV7  A1987 (-4.0A)
CV7  A1987 (-3.1A)
0.74A52.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M2Z_D_DEXD401_1
(GLUCOCORTICOID
RECEPTOR)		4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		6 / 12ASN A 770
GLY A 774
GLN A 776
THR A 945
PHE A 956
LEU A 960
CV7  A1987 (-3.1A)
None
CV7  A1987 (-3.0A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.7A)
None
1.22A52.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M2Z_D_DEXD401_1
(GLUCOCORTICOID
RECEPTOR)		5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens)		5 / 12MET A 197
ASN A 195
GLY A 193
GLN A 192
THR A 578
None
1.49A18.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M2Z_D_DEXD401_1
(GLUCOCORTICOID
RECEPTOR)		5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		8 / 12ASN A 770
GLN A 776
MET A 807
ARG A 817
CYH A 942
THR A 945
PHE A 956
LEU A 960
ECV  A1101 (-3.1A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
ECV  A1101 ( 4.7A)
None
0.48A45.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M2Z_D_DEXD401_1
(GLUCOCORTICOID
RECEPTOR)		5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		7 / 12ASN A 770
GLY A 774
GLN A 776
CYH A 942
THR A 945
PHE A 956
LEU A 960
ECV  A1101 (-3.1A)
None
ECV  A1101 (-2.9A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
ECV  A1101 ( 4.7A)
None
1.12A45.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M2Z_D_DEXD401_1
(GLUCOCORTICOID
RECEPTOR)		5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3
(Homo
sapiens)		5 / 12GLY A 486
GLN A 443
THR A 292
ILE A 296
LEU A 382
None
1.41A17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		1ef1 MOESIN
(Homo
sapiens)		5 / 12ASN A 226
LEU A 218
GLY A 219
THR C 558
ILE C 562
None
1.43A21.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		7 / 12LEU A 704
ASN A 705
LEU A 707
GLY A 708
GLN A 711
MET A 742
ARG A 752
BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 ( 4.2A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
0.91A46.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		7 / 12LEU A 704
LEU A 707
GLY A 708
GLN A 711
MET A 742
ARG A 752
MET A 787
BHM  A   1 (-4.0A)
BHM  A   1 ( 4.2A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
BHM  A   1 (-3.6A)
1.03A46.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		2nmp CYSTATHIONINE
GAMMA-LYASE
(Homo
sapiens)		5 / 12LEU A 302
GLN A 306
MET A 191
THR A 315
ILE A 290
None
1.35A22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		5 / 12LEU A 177
ASN A 178
LEU A 180
GLY A 181
GLN A 118
None
1.13A25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		5 / 12LEU A 230
LEU A 242
GLY A  64
THR A 175
ILE A  60
None
1.42A21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		3j0a TOLL-LIKE RECEPTOR 5
(Homo
sapiens)		5 / 12LEU A 347
LEU A 348
GLY A 349
THR A 379
ILE A 375
None
1.22A15.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)		8 / 12LEU A 718
ASN A 719
LEU A 721
GLY A 722
MET A 756
ARG A 766
MET A 801
THR A 894
WOW  A   1 (-4.2A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.9A)
0.88A49.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)		8 / 12LEU A 718
LEU A 721
GLY A 722
GLN A 725
MET A 756
ARG A 766
MET A 801
THR A 894
WOW  A   1 (-4.2A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.9A)
0.94A49.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens)		5 / 12LEU A 147
LEU A 188
GLY A 189
GLN A 168
THR A 194
None
1.23A20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		4d10 COP9 SIGNALOSOME
COMPLEX SUBUNIT 6
(Homo
sapiens)		5 / 12LEU F 150
LEU F 152
MET F  84
GLN F  76
ILE F 146
None
1.28A22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		4or2 SOLUBLE CYTOCHROME
B562, METABOTROPIC
GLUTAMATE RECEPTOR 1
(Escherichia
coli;
Homo
sapiens)		5 / 12LEU A 763
ASN A 760
LEU A 762
GLY A 761
MET A 791
None
FM9  A1901 (-3.9A)
None
None
None
1.30A21.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		5 / 12ASN A 564
GLY A 568
MET A 601
THR A 739
ILE A 747
MOF  A 801 (-3.0A)
None
MOF  A 801 (-3.7A)
MOF  A 801 (-3.9A)
MOF  A 801 ( 4.4A)
0.96A96.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		10 / 12LEU A 563
ASN A 564
LEU A 566
GLY A 567
GLN A 570
MET A 601
ARG A 611
MET A 646
THR A 739
ILE A 747
MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.2A)
MOF  A 801 (-4.4A)
MOF  A 801 (-3.9A)
MOF  A 801 ( 4.4A)
0.50A96.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		6 / 12MET A 560
ASN A 564
GLY A 567
GLN A 570
MET A 601
ILE A 747
MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 ( 4.4A)
0.74A96.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		4rm9 EZRIN
(Homo
sapiens)		5 / 12ASN A 226
LEU A 218
GLY A 219
THR A 567
ILE A 571
None
1.43A20.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		8 / 12LEU A 769
ASN A 770
LEU A 772
GLN A 776
MET A 807
ARG A 817
MET A 852
THR A 945
CV7  A1987 (-4.1A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.5A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.7A)
CV7  A1987 (-3.1A)
0.82A51.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		4wlp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5
(Homo
sapiens)		5 / 12LEU A  98
ASN A  99
LEU A  97
GLN A 119
ILE A  77
None
1.47A24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		5i35 ATYPICAL KINASE
ADCK3, MITOCHONDRIAL
(Homo
sapiens)		5 / 12MET A 313
LEU A 316
ASN A 317
LEU A 320
GLY A 321
None
1.21A23.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		7 / 12LEU A 769
ASN A 770
LEU A 772
GLN A 776
MET A 807
ARG A 817
THR A 945
ECV  A1101 (-4.7A)
ECV  A1101 (-3.1A)
ECV  A1101 ( 3.9A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
0.71A41.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		5 / 12LEU A 772
GLN A 776
MET A 807
ARG A 817
MET A 852
ECV  A1101 ( 3.9A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.7A)
1.36A41.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		5okl AFAMIN
(Homo
sapiens)		5 / 12LEU A 426
LEU A 411
GLY A 430
ARG A 524
ILE A 417
None
1.47A13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		5toa ESTROGEN RECEPTOR
BETA
(Homo
sapiens)		5 / 12MET A 295
LEU A 298
LEU A 301
MET A 336
ARG A 346
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
EST  A 601 ( 4.3A)
EST  A 601 ( 3.7A)
EST  A 601 (-4.1A)
1.16A27.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		5vem ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 5
(Homo
sapiens)		5 / 12MET A 193
LEU A 197
LEU A 336
GLY A 337
GLN A 243
None
1.46A21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		5vni PROTEIN TRANSPORT
PROTEIN SEC23A
(Homo
sapiens)		5 / 12LEU A 275
LEU A 274
GLY A 273
THR A 367
ILE A 345
None
1.36A14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens)		5 / 12LEU C  66
LEU C  65
GLY C  64
ARG C  24
THR C 137
None
1.46A5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		6cmo CHIMERA PROTEIN OF
SOLUBLE CYTOCHROME
B562 AND RHODOPSIN
(Escherichia
coli;
Homo
sapiens)		5 / 12MET R  44
LEU R  47
LEU R  50
GLY R  51
THR R  94
None
0.97A11.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_B_DEXB2999_1
(GLUCOCORTICOID
RECEPTOR)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		6 / 12ASN A 705
GLY A 708
GLN A 711
MET A 742
ARG A 752
PHE A 891
BHM  A   1 (-3.6A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
None
0.85A46.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_B_DEXB2999_1
(GLUCOCORTICOID
RECEPTOR)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		5 / 12GLY A 708
GLN A 711
MET A 742
ARG A 752
MET A 787
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
BHM  A   1 (-3.6A)
0.93A46.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_B_DEXB2999_1
(GLUCOCORTICOID
RECEPTOR)		3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)		9 / 12ASN A 719
GLY A 722
MET A 756
LEU A 763
ARG A 766
MET A 801
CYH A 891
THR A 894
PHE A 905
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.0A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.5A)
WOW  A   1 (-3.9A)
WOW  A   1 (-4.6A)
0.71A49.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_B_DEXB2999_1
(GLUCOCORTICOID
RECEPTOR)		3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)		9 / 12GLY A 722
GLN A 725
MET A 756
LEU A 763
ARG A 766
MET A 801
CYH A 891
THR A 894
PHE A 905
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.0A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.5A)
WOW  A   1 (-3.9A)
WOW  A   1 (-4.6A)
0.87A49.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_B_DEXB2999_1
(GLUCOCORTICOID
RECEPTOR)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		11 / 12ASN A 564
GLY A 567
GLN A 570
MET A 601
LEU A 608
ARG A 611
MET A 646
CYH A 736
THR A 739
ILE A 747
PHE A 749
MOF  A 801 (-3.0A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-4.2A)
MOF  A 801 (-4.4A)
MOF  A 801 (-3.7A)
MOF  A 801 (-3.9A)
MOF  A 801 ( 4.4A)
MOF  A 801 (-4.4A)
0.41A96.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_B_DEXB2999_1
(GLUCOCORTICOID
RECEPTOR)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		7 / 12ASN A 564
GLY A 568
MET A 601
CYH A 736
THR A 739
ILE A 747
PHE A 749
MOF  A 801 (-3.0A)
None
MOF  A 801 (-3.7A)
MOF  A 801 (-3.7A)
MOF  A 801 (-3.9A)
MOF  A 801 ( 4.4A)
MOF  A 801 (-4.4A)
0.99A96.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_B_DEXB2999_1
(GLUCOCORTICOID
RECEPTOR)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		7 / 12MET A 560
ASN A 564
GLY A 567
MET A 601
CYH A 736
ILE A 747
PHE A 749
MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
MOF  A 801 (-3.4A)
MOF  A 801 (-3.7A)
MOF  A 801 (-3.7A)
MOF  A 801 ( 4.4A)
MOF  A 801 (-4.4A)
0.77A96.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_B_DEXB2999_1
(GLUCOCORTICOID
RECEPTOR)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		6 / 12MET A 560
ASN A 564
LEU A 621
CYH A 736
ILE A 747
PHE A 749
MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
None
MOF  A 801 (-3.7A)
MOF  A 801 ( 4.4A)
MOF  A 801 (-4.4A)
1.25A96.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_B_DEXB2999_1
(GLUCOCORTICOID
RECEPTOR)		4s0v HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi)		5 / 12GLY A1032
MET A1029
LEU A1023
ILE A1055
PHE A1064
None
1.42A19.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_B_DEXB2999_1
(GLUCOCORTICOID
RECEPTOR)		4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		9 / 12ASN A 770
GLN A 776
MET A 807
LEU A 814
ARG A 817
MET A 852
CYH A 942
THR A 945
PHE A 956
CV7  A1987 (-3.1A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.7A)
CV7  A1987 (-4.0A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.7A)
0.61A51.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_B_DEXB2999_1
(GLUCOCORTICOID
RECEPTOR)		4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		5 / 12ASN A 770
GLY A 774
CYH A 942
THR A 945
PHE A 956
CV7  A1987 (-3.1A)
None
CV7  A1987 (-4.0A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.7A)
1.05A51.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_B_DEXB2999_1
(GLUCOCORTICOID
RECEPTOR)		4wmh HEME OXYGENASE 2
(Homo
sapiens)		5 / 12MET A 158
LEU A  97
MET A 206
THR A  41
PHE A 227
None
1.45A22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_B_DEXB2999_1
(GLUCOCORTICOID
RECEPTOR)		5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens)		5 / 12MET A 313
ASN A 315
GLY A 317
LEU A 947
THR A 360
None
NI  A1601 (-3.3A)
None
None
None
1.47A11.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_B_DEXB2999_1
(GLUCOCORTICOID
RECEPTOR)		5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		8 / 12ASN A 770
GLN A 776
MET A 807
LEU A 814
ARG A 817
CYH A 942
THR A 945
PHE A 956
ECV  A1101 (-3.1A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
ECV  A1101 ( 4.7A)
0.50A41.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_B_DEXB2999_1
(GLUCOCORTICOID
RECEPTOR)		5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		5 / 12ASN A 770
GLY A 774
CYH A 942
THR A 945
PHE A 956
ECV  A1101 (-3.1A)
None
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
ECV  A1101 ( 4.7A)
0.97A41.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_B_DEXB2999_1
(GLUCOCORTICOID
RECEPTOR)		5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		5 / 12GLN A 776
MET A 807
LEU A 814
ARG A 817
MET A 852
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.7A)
1.27A41.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_B_DEXB2999_1
(GLUCOCORTICOID
RECEPTOR)		6au8 GOLGI TO ER TRAFFIC
PROTEIN 4 HOMOLOG
LARGE PROLINE-RICH
PROTEIN BAG6
(Homo
sapiens)		5 / 12GLN C1023
LEU A 266
THR A 220
ILE A 226
PHE A 232
None
1.35A11.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_C_DEXC3999_1
(GLUCOCORTICOID
RECEPTOR)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		6 / 12ASN A 705
GLY A 708
GLN A 711
MET A 742
ARG A 752
LEU A 873
BHM  A   1 (-3.6A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
BHM  A   1 (-4.4A)
0.81A46.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_C_DEXC3999_1
(GLUCOCORTICOID
RECEPTOR)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		5 / 12GLY A 708
GLN A 711
MET A 742
ARG A 752
MET A 787
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
BHM  A   1 (-3.6A)
1.06A46.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_C_DEXC3999_1
(GLUCOCORTICOID
RECEPTOR)		3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)		9 / 12ASN A 719
GLY A 722
MET A 756
LEU A 763
ARG A 766
MET A 801
LEU A 887
CYH A 891
THR A 894
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.0A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-4.0A)
WOW  A   1 (-3.5A)
WOW  A   1 (-3.9A)
0.82A49.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_C_DEXC3999_1
(GLUCOCORTICOID
RECEPTOR)		3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)		7 / 12GLY A 722
GLN A 725
MET A 756
ARG A 766
MET A 801
LEU A 887
CYH A 891
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-4.0A)
WOW  A   1 (-3.5A)
0.90A49.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_C_DEXC3999_1
(GLUCOCORTICOID
RECEPTOR)		3kv4 PHD FINGER PROTEIN 8
(Homo
sapiens)		5 / 12GLY A 308
LEU A 137
LEU A 328
CYH A 327
THR A 323
None
1.46A22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_C_DEXC3999_1
(GLUCOCORTICOID
RECEPTOR)		4mdr AP-4 COMPLEX SUBUNIT
MU-1
(Homo
sapiens)		5 / 12GLY A 277
GLN A 276
LEU A 220
MET A 226
LEU A 272
None
1.42A21.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_C_DEXC3999_1
(GLUCOCORTICOID
RECEPTOR)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		10 / 12ASN A 564
GLY A 567
GLN A 570
MET A 601
LEU A 608
ARG A 611
MET A 646
LEU A 732
CYH A 736
THR A 739
MOF  A 801 (-3.0A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-4.2A)
MOF  A 801 (-4.4A)
MOF  A 801 ( 4.2A)
MOF  A 801 (-3.7A)
MOF  A 801 (-3.9A)
0.45A96.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_C_DEXC3999_1
(GLUCOCORTICOID
RECEPTOR)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		5 / 12ASN A 564
GLY A 568
MET A 601
CYH A 736
THR A 739
MOF  A 801 (-3.0A)
None
MOF  A 801 (-3.7A)
MOF  A 801 (-3.7A)
MOF  A 801 (-3.9A)
1.16A96.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_C_DEXC3999_1
(GLUCOCORTICOID
RECEPTOR)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		6 / 12MET A 560
ASN A 564
GLY A 567
MET A 601
LEU A 732
CYH A 736
MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
MOF  A 801 (-3.4A)
MOF  A 801 (-3.7A)
MOF  A 801 ( 4.2A)
MOF  A 801 (-3.7A)
0.83A96.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_C_DEXC3999_1
(GLUCOCORTICOID
RECEPTOR)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		6 / 12MET A 601
LEU A 608
GLN A 642
MET A 646
LEU A 732
CYH A 736
MOF  A 801 (-3.7A)
MOF  A 801 ( 4.6A)
None
MOF  A 801 (-4.4A)
MOF  A 801 ( 4.2A)
MOF  A 801 (-3.7A)
1.04A96.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_C_DEXC3999_1
(GLUCOCORTICOID
RECEPTOR)		4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct)		5 / 12MET A1756
GLY A3756
LEU A3762
GLN A3752
LEU A3779
None
1.42A6.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_C_DEXC3999_1
(GLUCOCORTICOID
RECEPTOR)		4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		9 / 12ASN A 770
GLN A 776
MET A 807
LEU A 814
ARG A 817
MET A 852
LEU A 938
CYH A 942
THR A 945
CV7  A1987 (-3.1A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.7A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-4.0A)
CV7  A1987 (-3.1A)
0.79A51.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_C_DEXC3999_1
(GLUCOCORTICOID
RECEPTOR)		5lf9 NUCLEOSIDE
DIPHOSPHATE-LINKED
MOIETY X MOTIF 22
(Homo
sapiens)		5 / 12ASN A  94
GLY A 218
LEU A   8
LEU A 121
THR A  85
None
1.38A22.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_C_DEXC3999_1
(GLUCOCORTICOID
RECEPTOR)		5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		8 / 12ASN A 770
GLN A 776
MET A 807
LEU A 814
ARG A 817
LEU A 938
CYH A 942
THR A 945
ECV  A1101 (-3.1A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 ( 4.3A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
0.54A41.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_C_DEXC3999_1
(GLUCOCORTICOID
RECEPTOR)		5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		5 / 12ASN A 770
GLY A 774
MET A 807
CYH A 942
THR A 945
ECV  A1101 (-3.1A)
None
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
1.21A41.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_C_DEXC3999_1
(GLUCOCORTICOID
RECEPTOR)		5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		6 / 12GLN A 776
MET A 807
LEU A 814
ARG A 817
MET A 852
LEU A 938
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.7A)
ECV  A1101 ( 4.3A)
1.40A41.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_D_DEXD4999_1
(GLUCOCORTICOID
RECEPTOR)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		6 / 12ASN A 705
GLY A 708
GLN A 711
MET A 742
ARG A 752
PHE A 891
BHM  A   1 (-3.6A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
None
0.91A46.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_D_DEXD4999_1
(GLUCOCORTICOID
RECEPTOR)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		6 / 12GLY A 708
GLN A 711
MET A 742
ARG A 752
PHE A 764
MET A 787
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
BHM  A   1 (-4.4A)
BHM  A   1 (-3.6A)
0.97A46.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_D_DEXD4999_1
(GLUCOCORTICOID
RECEPTOR)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		6 / 12GLY A 708
GLN A 711
MET A 742
ARG A 752
PHE A 764
PHE A 891
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
BHM  A   1 (-4.4A)
None
0.89A46.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_D_DEXD4999_1
(GLUCOCORTICOID
RECEPTOR)		3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)		9 / 12ASN A 719
GLY A 722
GLN A 725
MET A 756
ARG A 766
MET A 801
CYH A 891
THR A 894
PHE A 905
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.5A)
WOW  A   1 (-3.9A)
WOW  A   1 (-4.6A)
0.87A49.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_D_DEXD4999_1
(GLUCOCORTICOID
RECEPTOR)		3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)		9 / 12GLY A 722
GLN A 725
MET A 756
ARG A 766
PHE A 778
MET A 801
CYH A 891
THR A 894
PHE A 905
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
None
WOW  A   1 (-4.2A)
WOW  A   1 (-3.5A)
WOW  A   1 (-3.9A)
WOW  A   1 (-4.6A)
0.87A49.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_1
(GLUCOCORTICOID
RECEPTOR)		3keh GLUCOCEREBROSIDASE
(Homo
sapiens)		5 / 12GLY A 115
GLN A 169
PHE A  26
MET A  49
ILE A 402
None
SO4  A1502 (-3.8A)
GOL  A1509 (-3.8A)
None
None
1.35A22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_1
(GLUCOCORTICOID
RECEPTOR)		4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens)		5 / 12GLY A 128
ARG A 448
PHE A 130
ILE A 263
PHE A 264
None
HEM  A 601 (-3.8A)
0T3  A 602 (-4.0A)
None
None
1.28A20.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_D_DEXD4999_1
(GLUCOCORTICOID
RECEPTOR)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		11 / 12ASN A 564
GLY A 567
GLN A 570
MET A 601
ARG A 611
PHE A 623
MET A 646
CYH A 736
THR A 739
ILE A 747
PHE A 749
MOF  A 801 (-3.0A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.2A)
MOF  A 801 (-4.7A)
MOF  A 801 (-4.4A)
MOF  A 801 (-3.7A)
MOF  A 801 (-3.9A)
MOF  A 801 ( 4.4A)
MOF  A 801 (-4.4A)
0.51A96.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_D_DEXD4999_1
(GLUCOCORTICOID
RECEPTOR)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		7 / 12ASN A 564
GLY A 568
MET A 601
CYH A 736
THR A 739
ILE A 747
PHE A 749
MOF  A 801 (-3.0A)
None
MOF  A 801 (-3.7A)
MOF  A 801 (-3.7A)
MOF  A 801 (-3.9A)
MOF  A 801 ( 4.4A)
MOF  A 801 (-4.4A)
1.03A96.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_D_DEXD4999_1
(GLUCOCORTICOID
RECEPTOR)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		9 / 12MET A 560
ASN A 564
GLY A 567
GLN A 570
MET A 601
MET A 646
CYH A 736
ILE A 747
PHE A 749
MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.4A)
MOF  A 801 (-3.7A)
MOF  A 801 ( 4.4A)
MOF  A 801 (-4.4A)
0.67A96.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_D_DEXD4999_1
(GLUCOCORTICOID
RECEPTOR)		4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		9 / 12ASN A 770
GLN A 776
MET A 807
ARG A 817
PHE A 829
MET A 852
CYH A 942
THR A 945
PHE A 956
CV7  A1987 (-3.1A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
CV7  A1987 (-4.9A)
CV7  A1987 ( 3.7A)
CV7  A1987 (-4.0A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.7A)
0.76A51.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_D_DEXD4999_1
(GLUCOCORTICOID
RECEPTOR)		4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		5 / 12ASN A 770
GLY A 774
CYH A 942
THR A 945
PHE A 956
CV7  A1987 (-3.1A)
None
CV7  A1987 (-4.0A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.7A)
1.05A51.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_D_DEXD4999_1
(GLUCOCORTICOID
RECEPTOR)		5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		8 / 12ASN A 770
GLN A 776
MET A 807
ARG A 817
PHE A 829
CYH A 942
THR A 945
PHE A 956
ECV  A1101 (-3.1A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 ( 4.9A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
ECV  A1101 ( 4.7A)
0.67A41.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_D_DEXD4999_1
(GLUCOCORTICOID
RECEPTOR)		5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		5 / 12ASN A 770
GLY A 774
CYH A 942
THR A 945
PHE A 956
ECV  A1101 (-3.1A)
None
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
ECV  A1101 ( 4.7A)
0.98A41.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_2
(GLUCOCORTICOID
RECEPTOR)		1iap GUANINE NUCLEOTIDE
EXCHANGE FACTOR
P115RHOGEF
(Homo
sapiens)		4 / 5LEU A  76
MET A  60
LEU A  59
GLN A 153
None
1.45A20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_2
(GLUCOCORTICOID
RECEPTOR)		1pja PALMITOYL-PROTEIN
THIOESTERASE 2
PRECURSOR
(Homo
sapiens)		4 / 5LEU A 195
TRP A 210
LEU A  83
GLN A 139
None
1.45A22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_2
(GLUCOCORTICOID
RECEPTOR)		1shz RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens)		4 / 5LEU C  76
MET C  60
LEU C  59
GLN C 153
None
1.48A21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_2
(GLUCOCORTICOID
RECEPTOR)		1tzn ANTHRAX TOXIN
RECEPTOR 2
(Homo
sapiens)		4 / 5LEU a1069
MET a1078
LEU a1080
GLN a1067
None
1.47A22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_2
(GLUCOCORTICOID
RECEPTOR)		1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G
(Homo
sapiens)		4 / 5LEU A1376
TRP A1397
MET A1356
LEU A1359
None
1.22A22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_2
(GLUCOCORTICOID
RECEPTOR)		2jii SERINE/THREONINE-PRO
TEIN KINASE VRK3
MOLECULE: VACCINIA
RELATED KINASE 3
(Homo
sapiens)		4 / 5LEU A 211
MET A 145
LEU A 149
GLN A 177
None
1.27A23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_2
(GLUCOCORTICOID
RECEPTOR)		2p0d RHO
GTPASE-ACTIVATING
PROTEIN 9
(Homo
sapiens)		4 / 5LEU A 403
TRP A 345
MET A 331
LEU A 329
None
I3P  A 800 (-4.1A)
None
None
1.35A19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_2
(GLUCOCORTICOID
RECEPTOR)		2pbc FK506-BINDING
PROTEIN 2
(Homo
sapiens)		4 / 5LEU A  70
TRP A  89
MET A  54
GLN A  72
None
PEG  A 201 (-3.7A)
None
None
1.50A17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_2
(GLUCOCORTICOID
RECEPTOR)		4krf PROTEIN ARGONAUTE-1
(Homo
sapiens)		4 / 5LEU A 154
MET A 140
LEU A 141
GLN A 158
None
1.05A15.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_D_DEXD4999_2
(GLUCOCORTICOID
RECEPTOR)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		4 / 5LEU A 563
TRP A 600
MET A 604
LEU A 608
MOF  A 801 (-3.9A)
None
None
MOF  A 801 ( 4.6A)
0.43A96.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_2
(GLUCOCORTICOID
RECEPTOR)		4uhi STEROL 14-ALPHA
DEMETHYLASE
(Homo
sapiens)		4 / 5LEU A 286
MET A 304
LEU A 305
GLN A 269
None
1.01A20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_2
(GLUCOCORTICOID
RECEPTOR)		4wjl INACTIVE DIPEPTIDYL
PEPTIDASE 10
(Homo
sapiens)		4 / 5LEU A 575
TRP A 584
LEU A 565
GLN A 548
None
1.48A16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_2
(GLUCOCORTICOID
RECEPTOR)		5ojj UBIQUITIN-CONJUGATIN
G ENZYME E2 T
(Homo
sapiens)		4 / 5LEU A   7
MET A  13
LEU A  14
GLN A  26
None
1.00A19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_2
(GLUCOCORTICOID
RECEPTOR)		5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens)		4 / 5LEU C 862
TRP C 776
LEU C 793
GLN C 786
None
1.44A5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_1
(GLUCOCORTICOID
RECEPTOR 2)		1xb7 STEROID HORMONE
RECEPTOR ERR1
(Homo
sapiens)		5 / 12LEU A 324
TRP A 361
MET A 362
ARG A 372
VAL A 498
None
1.13A26.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN8_A_DEXA247_1
(GLUCOCORTICOID
RECEPTOR 2)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		5 / 12GLY A 708
GLN A 711
MET A 742
ARG A 752
MET A 787
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
BHM  A   1 (-3.6A)
0.92A53.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN8_A_DEXA247_1
(GLUCOCORTICOID
RECEPTOR 2)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		6 / 12LEU A 704
ASN A 705
GLY A 708
GLN A 711
MET A 742
VAL A 889
BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
None
0.95A53.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN8_A_DEXA247_1
(GLUCOCORTICOID
RECEPTOR 2)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		5 / 12LEU A 704
ASN A 705
TRP A 741
MET A 742
VAL A 889
BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
None
BHM  A   1 ( 4.0A)
None
1.44A53.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN8_A_DEXA247_1
(GLUCOCORTICOID
RECEPTOR 2)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		6 / 12LEU A 704
GLY A 708
GLN A 711
MET A 742
ARG A 752
VAL A 889
BHM  A   1 (-4.0A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
None
0.92A53.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_1
(GLUCOCORTICOID
RECEPTOR 2)		2ljr GLUTATHIONE
S-TRANSFERASE
(Homo
sapiens)		5 / 12LEU A 114
GLY A 111
GLN A  12
ARG A  15
VAL A 127
None
1.38A19.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN8_A_DEXA247_1
(GLUCOCORTICOID
RECEPTOR 2)		3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)		7 / 12ASN A 719
TRP A 755
MET A 756
MET A 801
CYH A 891
THR A 894
VAL A 903
WOW  A   1 (-3.3A)
None
WOW  A   1 ( 4.1A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.5A)
WOW  A   1 (-3.9A)
None
1.23A58.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN8_A_DEXA247_1
(GLUCOCORTICOID
RECEPTOR 2)		3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)		6 / 12GLY A 722
GLN A 725
MET A 756
ARG A 766
MET A 801
CYH A 891
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.5A)
0.91A58.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN8_A_DEXA247_1
(GLUCOCORTICOID
RECEPTOR 2)		3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)		9 / 12LEU A 718
ASN A 719
GLY A 722
MET A 756
ARG A 766
MET A 801
CYH A 891
THR A 894
VAL A 903
WOW  A   1 (-4.2A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.5A)
WOW  A   1 (-3.9A)
None
0.79A58.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN8_A_DEXA247_1
(GLUCOCORTICOID
RECEPTOR 2)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		6 / 12ASN A 564
GLY A 568
TRP A 600
MET A 601
CYH A 736
THR A 739
MOF  A 801 (-3.0A)
None
None
MOF  A 801 (-3.7A)
MOF  A 801 (-3.7A)
MOF  A 801 (-3.9A)
0.97A76.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN8_A_DEXA247_1
(GLUCOCORTICOID
RECEPTOR 2)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		10 / 12LEU A 563
ASN A 564
GLY A 567
GLN A 570
TRP A 600
MET A 601
ARG A 611
MET A 646
CYH A 736
THR A 739
MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
None
MOF  A 801 (-3.7A)
MOF  A 801 (-4.2A)
MOF  A 801 (-4.4A)
MOF  A 801 (-3.7A)
MOF  A 801 (-3.9A)
0.43A76.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN8_A_DEXA247_1
(GLUCOCORTICOID
RECEPTOR 2)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		5 / 12TRP A 600
MET A 601
GLN A 642
MET A 646
CYH A 736
None
MOF  A 801 (-3.7A)
None
MOF  A 801 (-4.4A)
MOF  A 801 (-3.7A)
1.04A76.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN8_A_DEXA247_1
(GLUCOCORTICOID
RECEPTOR 2)		4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		10 / 12LEU A 769
ASN A 770
GLN A 776
TRP A 806
MET A 807
ARG A 817
MET A 852
CYH A 942
THR A 945
VAL A 954
CV7  A1987 (-4.1A)
CV7  A1987 (-3.1A)
CV7  A1987 (-3.0A)
None
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.7A)
CV7  A1987 (-4.0A)
CV7  A1987 (-3.1A)
None
0.63A57.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN8_A_DEXA247_1
(GLUCOCORTICOID
RECEPTOR 2)		5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		7 / 12ASN A 770
GLY A 774
GLN A 776
TRP A 806
CYH A 942
THR A 945
VAL A 954
ECV  A1101 (-3.1A)
None
ECV  A1101 (-2.9A)
None
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
None
1.15A42.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN8_A_DEXA247_1
(GLUCOCORTICOID
RECEPTOR 2)		5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		5 / 12GLN A 776
TRP A 806
MET A 807
ARG A 817
MET A 852
ECV  A1101 (-2.9A)
None
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.7A)
1.24A42.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN8_A_DEXA247_1
(GLUCOCORTICOID
RECEPTOR 2)		5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		9 / 12LEU A 769
ASN A 770
GLN A 776
TRP A 806
MET A 807
ARG A 817
CYH A 942
THR A 945
VAL A 954
ECV  A1101 (-4.7A)
ECV  A1101 (-3.1A)
ECV  A1101 (-2.9A)
None
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
None
0.41A42.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN8_A_DEXA247_1
(GLUCOCORTICOID
RECEPTOR 2)		5toa ESTROGEN RECEPTOR
BETA
(Homo
sapiens)		5 / 12LEU A 298
TRP A 335
MET A 336
ARG A 346
VAL A 485
EST  A 601 (-4.1A)
None
EST  A 601 ( 3.7A)
EST  A 601 (-4.1A)
None
0.67A30.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		1k27 5'-DEOXY-5'-METHYLTH
IOADENOSINE
PHOSPHORYLASE
(Homo
sapiens)		3 / 3MET A 196
MET A 185
PHE A 177
MTM  A 401 (-3.7A)
None
MTM  A 401 (-4.8A)
1.18A19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens)		3 / 3MET A 111
MET A  52
PHE A 134
None
1.34A20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		2ls8 C-TYPE LECTIN DOMAIN
FAMILY 4 MEMBER D
(Homo
sapiens)		3 / 3MET A  34
MET A   1
PHE A  16
None
0.96A18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		2pid TYROSYL-TRNA
SYNTHETASE
(Homo
sapiens)		3 / 3MET A 195
MET A 252
PHE A 220
None
0.81A22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		3e4c CASPASE-1
(Homo
sapiens)		3 / 3MET A 189
MET A 345
PHE A 349
None
1.14A22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		4gmj CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
(Homo
sapiens)		3 / 3MET A1127
MET A1136
PHE A1152
None
1.30A20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		4k81 GROWTH FACTOR
RECEPTOR-BOUND
PROTEIN 14
(Homo
sapiens)		3 / 3MET A 208
MET A 227
PHE A 203
None
1.12A19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		4nen INTEGRIN BETA-2
(Homo
sapiens)		3 / 3MET B 304
MET B 111
PHE B 245
None
1.33A16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		4rwa SOLUBLE CYTOCHROME
B562,DELTA-TYPE
OPIOID RECEPTOR
(Escherichia
coli;
Homo
sapiens)		3 / 3MET A 132
MET A 141
PHE A 222
None
OLC  A1201 (-3.5A)
None
1.02A21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens)		3 / 3MET A 918
MET A 970
PHE A 961
PTR  A 928 (-4.9A)
None
None
1.23A24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens)		3 / 3MET A1656
MET A2526
PHE A2440
None
1.28A18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_B_DEXB247_1
(GLUCOCORTICOID
RECEPTOR 2)		1wch PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 13
(Homo
sapiens)		5 / 12GLY A2416
MET A2308
MET A2395
VAL A2463
PHE A2459
None
1.14A21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_B_DEXB247_1
(GLUCOCORTICOID
RECEPTOR 2)		1xb7 STEROID HORMONE
RECEPTOR ERR1
(Homo
sapiens)		5 / 12LEU A 324
TRP A 361
MET A 362
ARG A 372
VAL A 498
None
1.15A26.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN8_B_DEXB247_1
(GLUCOCORTICOID
RECEPTOR 2)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		5 / 12GLY A 708
GLN A 711
MET A 742
ARG A 752
MET A 787
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
BHM  A   1 (-3.6A)
0.89A53.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN8_B_DEXB247_1
(GLUCOCORTICOID
RECEPTOR 2)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		8 / 12LEU A 704
ASN A 705
GLY A 708
GLN A 711
MET A 742
ARG A 752
VAL A 889
PHE A 891
BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
None
None
0.94A53.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_B_DEXB247_1
(GLUCOCORTICOID
RECEPTOR 2)		3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens)		5 / 12GLY A 352
TRP A 428
THR A 437
VAL A 359
PHE A 362
None
1.34A17.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN8_B_DEXB247_1
(GLUCOCORTICOID
RECEPTOR 2)		3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)		8 / 12ASN A 719
TRP A 755
MET A 756
MET A 801
CYH A 891
THR A 894
VAL A 903
PHE A 905
WOW  A   1 (-3.3A)
None
WOW  A   1 ( 4.1A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.5A)
WOW  A   1 (-3.9A)
None
WOW  A   1 (-4.6A)
1.21A58.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN8_B_DEXB247_1
(GLUCOCORTICOID
RECEPTOR 2)		3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)		6 / 12GLY A 722
GLN A 725
MET A 756
ARG A 766
MET A 801
CYH A 891
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.5A)
0.93A58.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN8_B_DEXB247_1
(GLUCOCORTICOID
RECEPTOR 2)		3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)		10 / 12LEU A 718
ASN A 719
GLY A 722
MET A 756
ARG A 766
MET A 801
CYH A 891
THR A 894
VAL A 903
PHE A 905
WOW  A   1 (-4.2A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.5A)
WOW  A   1 (-3.9A)
None
WOW  A   1 (-4.6A)
0.78A58.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_B_DEXB247_1
(GLUCOCORTICOID
RECEPTOR 2)		3nxp PRETHROMBIN-1
(Homo
sapiens)		5 / 12LEU A 560
ASN A 559
GLY A 536
TRP A 607
VAL A 417
None
1.50A20.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN8_B_DEXB247_1
(GLUCOCORTICOID
RECEPTOR 2)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		7 / 12ASN A 564
GLY A 568
GLN A 570
TRP A 600
MET A 601
CYH A 736
PHE A 749
MOF  A 801 (-3.0A)
None
MOF  A 801 (-2.9A)
None
MOF  A 801 (-3.7A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.4A)
1.08A76.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN8_B_DEXB247_1
(GLUCOCORTICOID
RECEPTOR 2)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		11 / 12LEU A 563
ASN A 564
GLY A 567
GLN A 570
TRP A 600
MET A 601
ARG A 611
MET A 646
CYH A 736
THR A 739
PHE A 749
MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
None
MOF  A 801 (-3.7A)
MOF  A 801 (-4.2A)
MOF  A 801 (-4.4A)
MOF  A 801 (-3.7A)
MOF  A 801 (-3.9A)
MOF  A 801 (-4.4A)
0.45A76.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN8_B_DEXB247_1
(GLUCOCORTICOID
RECEPTOR 2)		4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		7 / 12ASN A 770
GLY A 774
GLN A 776
TRP A 806
THR A 945
VAL A 954
PHE A 956
CV7  A1987 (-3.1A)
None
CV7  A1987 (-3.0A)
None
CV7  A1987 (-3.1A)
None
CV7  A1987 ( 4.7A)
1.15A57.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN8_B_DEXB247_1
(GLUCOCORTICOID
RECEPTOR 2)		4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		11 / 12LEU A 769
ASN A 770
GLN A 776
TRP A 806
MET A 807
ARG A 817
MET A 852
CYH A 942
THR A 945
VAL A 954
PHE A 956
CV7  A1987 (-4.1A)
CV7  A1987 (-3.1A)
CV7  A1987 (-3.0A)
None
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.7A)
CV7  A1987 (-4.0A)
CV7  A1987 (-3.1A)
None
CV7  A1987 ( 4.7A)
0.61A57.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN8_B_DEXB247_1
(GLUCOCORTICOID
RECEPTOR 2)		5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		8 / 12ASN A 770
GLY A 774
GLN A 776
TRP A 806
CYH A 942
THR A 945
VAL A 954
PHE A 956
ECV  A1101 (-3.1A)
None
ECV  A1101 (-2.9A)
None
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
None
ECV  A1101 ( 4.7A)
1.07A42.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN8_B_DEXB247_1
(GLUCOCORTICOID
RECEPTOR 2)		5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		5 / 12GLN A 776
TRP A 806
MET A 807
ARG A 817
MET A 852
ECV  A1101 (-2.9A)
None
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.7A)
1.21A42.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN8_B_DEXB247_1
(GLUCOCORTICOID
RECEPTOR 2)		5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		10 / 12LEU A 769
ASN A 770
GLN A 776
TRP A 806
MET A 807
ARG A 817
CYH A 942
THR A 945
VAL A 954
PHE A 956
ECV  A1101 (-4.7A)
ECV  A1101 (-3.1A)
ECV  A1101 (-2.9A)
None
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
None
ECV  A1101 ( 4.7A)
0.40A42.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN8_B_DEXB247_1
(GLUCOCORTICOID
RECEPTOR 2)		5toa ESTROGEN RECEPTOR
BETA
(Homo
sapiens)		5 / 12LEU A 298
TRP A 335
MET A 336
ARG A 346
VAL A 485
EST  A 601 (-4.1A)
None
EST  A 601 ( 3.7A)
EST  A 601 (-4.1A)
None
0.70A30.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNE_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens)		5 / 12ASN A 242
GLY A 312
GLN A 316
LEU A  95
ILE A 265
ILP  A 400 (-3.5A)
ILP  A 400 (-3.5A)
None
ACY  A1005 ( 4.8A)
None
1.30A22.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNE_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		6 / 12ASN A 705
GLY A 708
GLN A 711
MET A 742
ARG A 752
LEU A 873
BHM  A   1 (-3.6A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
BHM  A   1 (-4.4A)
0.80A49.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNE_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		6 / 12ASN A 705
GLY A 708
GLN A 711
MET A 742
LEU A 873
PHE A 891
BHM  A   1 (-3.6A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-4.4A)
None
0.94A49.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNE_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		3c6g CYTOCHROME P450 2R1
(Homo
sapiens)		5 / 12GLY A  42
LEU A  81
THR A 398
ILE A 394
PHE A  39
None
0.95A20.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNE_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)		8 / 12ASN A 719
GLY A 722
MET A 756
ARG A 766
MET A 801
LEU A 887
THR A 894
PHE A 905
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-4.0A)
WOW  A   1 (-3.9A)
WOW  A   1 (-4.6A)
0.83A53.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNE_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)		7 / 12ASN A 719
TRP A 755
MET A 756
MET A 801
LEU A 887
THR A 894
PHE A 905
WOW  A   1 (-3.3A)
None
WOW  A   1 ( 4.1A)
WOW  A   1 (-4.2A)
WOW  A   1 (-4.0A)
WOW  A   1 (-3.9A)
WOW  A   1 (-4.6A)
1.22A53.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNE_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)		6 / 12GLY A 722
GLN A 725
MET A 756
ARG A 766
MET A 801
LEU A 887
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-4.0A)
0.96A53.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNE_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		12 / 12MET A 560
ASN A 564
GLY A 567
GLN A 570
TRP A 600
MET A 601
ARG A 611
MET A 646
LEU A 732
THR A 739
ILE A 747
PHE A 749
MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
None
MOF  A 801 (-3.7A)
MOF  A 801 (-4.2A)
MOF  A 801 (-4.4A)
MOF  A 801 ( 4.2A)
MOF  A 801 (-3.9A)
MOF  A 801 ( 4.4A)
MOF  A 801 (-4.4A)
0.49A92.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNE_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		9 / 12MET A 560
ASN A 564
GLY A 568
GLN A 570
TRP A 600
MET A 601
THR A 739
ILE A 747
PHE A 749
MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
None
MOF  A 801 (-2.9A)
None
MOF  A 801 (-3.7A)
MOF  A 801 (-3.9A)
MOF  A 801 ( 4.4A)
MOF  A 801 (-4.4A)
1.05A92.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNE_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		8 / 12ASN A 770
GLN A 776
TRP A 806
MET A 807
ARG A 817
LEU A 938
THR A 945
PHE A 956
CV7  A1987 (-3.1A)
CV7  A1987 (-3.0A)
None
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.7A)
0.26A54.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNE_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		8 / 12ASN A 770
GLN A 776
TRP A 806
MET A 807
ARG A 817
MET A 852
LEU A 938
THR A 945
CV7  A1987 (-3.1A)
CV7  A1987 (-3.0A)
None
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.7A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.1A)
0.70A54.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNE_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		6 / 12ASN A 770
GLY A 774
GLN A 776
TRP A 806
THR A 945
PHE A 956
CV7  A1987 (-3.1A)
None
CV7  A1987 (-3.0A)
None
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.7A)
1.27A54.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNE_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		8 / 12ASN A 770
GLN A 776
TRP A 806
MET A 807
ARG A 817
LEU A 938
THR A 945
PHE A 956
ECV  A1101 (-3.1A)
ECV  A1101 (-2.9A)
None
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 ( 4.3A)
ECV  A1101 (-3.2A)
ECV  A1101 ( 4.7A)
0.46A47.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNE_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		6 / 12ASN A 770
GLY A 774
GLN A 776
TRP A 806
THR A 945
PHE A 956
ECV  A1101 (-3.1A)
None
ECV  A1101 (-2.9A)
None
ECV  A1101 (-3.2A)
ECV  A1101 ( 4.7A)
1.28A47.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNE_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		6 / 12GLN A 776
TRP A 806
MET A 807
ARG A 817
MET A 852
LEU A 938
ECV  A1101 (-2.9A)
None
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.7A)
ECV  A1101 ( 4.3A)
1.37A47.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNE_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		5vxz GROWTH
ARREST-SPECIFIC
PROTEIN 6
(Homo
sapiens)		5 / 12GLY A 339
GLN A 411
LEU A 359
ILE A 426
PHE A 428
NAG  A 701 (-3.0A)
None
None
None
None
1.43A21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		1d1t ALCOHOL
DEHYDROGENASE CLASS
IV SIGMA CHAIN
(Homo
sapiens)		5 / 12GLY A  66
VAL A 371
LEU A 171
CYH A 174
PHE A  93
None
None
None
ZN  A 376 (-2.0A)
ACT  A 501 (-3.6A)
1.42A21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		1e33 ARYLSULFATASE A
(Homo
sapiens)		5 / 12GLY P 119
VAL P 107
LEU P 340
THR P 274
PHE P 219
None
1.28A20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		1jpl ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA3
(Homo
sapiens)		5 / 12ASN A  75
GLY A  77
VAL A  84
LEU A  69
ILE A  30
None
1.31A21.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		5 / 12ASN A 705
GLN A 711
MET A 742
ARG A 752
LEU A 873
BHM  A   1 (-3.6A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
BHM  A   1 (-4.4A)
0.83A49.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		5 / 12ASN A 705
GLN A 711
MET A 742
LEU A 873
PHE A 891
BHM  A   1 (-3.6A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-4.4A)
None
0.96A49.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		5 / 12ASN A 705
GLY A 708
GLN A 711
MET A 742
ARG A 752
BHM  A   1 (-3.6A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
0.79A49.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		5 / 12ASN A 705
GLY A 708
GLN A 711
MET A 742
PHE A 891
BHM  A   1 (-3.6A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
None
0.89A49.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		5 / 12GLN A 711
MET A 742
VAL A 746
ARG A 752
LEU A 873
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 (-3.8A)
BHM  A   1 (-4.4A)
0.73A49.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		5 / 12GLY A 708
GLN A 711
MET A 742
VAL A 746
ARG A 752
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 (-3.8A)
0.60A49.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		2jjd RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE EPSILON
(Homo
sapiens)		5 / 12ASN A 451
GLY A 446
VAL A 468
ARG A 669
LEU A 470
None
1.24A16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		2ksb SUBSTANCE-P RECEPTOR
(Homo
sapiens)		5 / 12VAL A 252
MET A 249
LEU A 308
CYH A 306
ILE A  56
None
1.39A20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		2wkp NPH1-1, RAS-RELATED
C3 BOTULINUM TOXIN
SUBSTRATE 1
(Avena
sativa;
Homo
sapiens)		5 / 12GLY A 555
VAL A 551
LEU A 563
CYH A 561
ILE A 576
GTP  A1724 (-3.6A)
None
None
GTP  A1724 (-3.4A)
None
1.37A22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		3a98 ENGULFMENT AND CELL
MOTILITY PROTEIN 1
(Homo
sapiens)		5 / 12VAL B 610
LEU B 579
CYH B 577
THR B 560
PHE B 562
None
1.35A24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		3b6u KINESIN-LIKE PROTEIN
KIF3B
(Homo
sapiens)		5 / 12ASN A 242
GLY A  90
VAL A  10
LEU A 305
ILE A 218
None
1.38A20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		3c6g CYTOCHROME P450 2R1
(Homo
sapiens)		5 / 12GLY A  42
LEU A  81
THR A 398
ILE A 394
PHE A  39
None
1.03A20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		3f70 LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE 2
PROTEIN
(Homo
sapiens)		5 / 12GLY A 572
LEU A 601
CYH A 554
ILE A 568
PHE A 570
None
None
MLZ  A  20 ( 4.1A)
None
MLZ  A  20 (-4.0A)
1.35A21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		3feo MBT
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		5 / 12GLY A 399
LEU A 428
CYH A 381
ILE A 395
PHE A 397
None
1.26A19.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)		8 / 12ASN A 719
GLY A 722
MET A 756
ARG A 766
LEU A 887
CYH A 891
THR A 894
PHE A 905
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.0A)
WOW  A   1 (-3.5A)
WOW  A   1 (-3.9A)
WOW  A   1 (-4.6A)
0.64A54.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)		8 / 12GLY A 722
GLN A 725
MET A 756
VAL A 760
ARG A 766
MET A 801
LEU A 887
CYH A 891
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-4.0A)
WOW  A   1 (-3.5A)
1.02A54.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)		8 / 12GLY A 722
MET A 756
VAL A 760
ARG A 766
MET A 801
LEU A 887
CYH A 891
THR A 894
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-4.0A)
WOW  A   1 (-3.5A)
WOW  A   1 (-3.9A)
0.85A54.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		4eyc CATHELICIDIN
ANTIMICROBIAL
PEPTIDE
(Homo
sapiens)		5 / 12ASN A  47
GLY A  45
VAL A  39
LEU A  58
THR A  84
None
1.16A20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		4nnd TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 18
(Homo
sapiens)		5 / 12ASN A  56
GLY A  51
VAL A  73
ARG A 271
LEU A  75
None
1.30A20.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		11 / 12ASN A 564
GLY A 567
GLN A 570
MET A 601
ARG A 611
MET A 646
LEU A 732
CYH A 736
THR A 739
ILE A 747
PHE A 749
MOF  A 801 (-3.0A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.2A)
MOF  A 801 (-4.4A)
MOF  A 801 ( 4.2A)
MOF  A 801 (-3.7A)
MOF  A 801 (-3.9A)
MOF  A 801 ( 4.4A)
MOF  A 801 (-4.4A)
0.59A92.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		7 / 12ASN A 564
GLY A 568
MET A 601
CYH A 736
THR A 739
ILE A 747
PHE A 749
MOF  A 801 (-3.0A)
None
MOF  A 801 (-3.7A)
MOF  A 801 (-3.7A)
MOF  A 801 (-3.9A)
MOF  A 801 ( 4.4A)
MOF  A 801 (-4.4A)
0.90A92.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		8 / 12ASN A 770
GLN A 776
MET A 807
ARG A 817
LEU A 938
CYH A 942
THR A 945
PHE A 956
CV7  A1987 (-3.1A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-4.0A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.7A)
0.29A54.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		5 / 12ASN A 770
GLY A 774
MET A 807
THR A 945
PHE A 956
CV7  A1987 (-3.1A)
None
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.7A)
1.11A54.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		5 / 12GLN A 776
MET A 807
ARG A 817
MET A 852
LEU A 938
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.7A)
CV7  A1987 ( 3.9A)
0.90A54.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		5a8z NEUTROPHIL ELASTASE
(Homo
sapiens)		5 / 12GLN A 233
VAL A 181
LEU A 199
THR A  45
ILE A  47
None
1.38A19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens)		5 / 12ASN A  98
GLY A  76
GLN A 318
LEU A 672
ILE A 100
None
1.31A11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		5epg ALDEHYDE OXIDASE
(Homo
sapiens)		5 / 12GLY A  50
GLN A 348
MET A 121
CYH A 149
ILE A1238
FES  A3002 (-3.4A)
None
None
FES  A3001 (-2.1A)
None
1.39A12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		5hde TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 12
(Homo
sapiens)		5 / 12ASN A  58
GLY A  53
VAL A  75
ARG A 273
LEU A  77
None
1.35A20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		5hzh RAS-RELATED C3
BOTULINUM TOXIN
SUBSTRATE
1,NPH1-1,RAS-RELATED
C3 BOTULINUM TOXIN
SUBSTRATE 1
(Avena
sativa;
Homo
sapiens)		5 / 12GLY A  12
VAL A   8
LEU A  20
CYH A  18
ILE A  33
GTP  A 401 (-3.5A)
None
None
GTP  A 401 (-3.4A)
None
1.33A22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens)		5 / 12ASN A 273
GLY A 268
VAL A 290
ARG A 501
LEU A 292
None
1.32A19.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		8 / 12ASN A 770
GLN A 776
MET A 807
ARG A 817
LEU A 938
CYH A 942
THR A 945
PHE A 956
ECV  A1101 (-3.1A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 ( 4.3A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
ECV  A1101 ( 4.7A)
0.48A47.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		6 / 12ASN A 770
GLY A 774
GLN A 776
MET A 807
THR A 945
PHE A 956
ECV  A1101 (-3.1A)
None
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-3.2A)
ECV  A1101 ( 4.7A)
1.20A47.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		5vni PROTEIN TRANSPORT
PROTEIN SEC24A
(Homo
sapiens)		5 / 12ASN B 778
MET B 627
LEU B 507
ILE B 743
PHE B 745
None
1.23A17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		5vni PROTEIN TRANSPORT
PROTEIN SEC24A
(Homo
sapiens)		5 / 12GLY B 764
VAL B 779
LEU B 807
ILE B 759
PHE B 762
None
1.37A17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		5vxz GROWTH
ARREST-SPECIFIC
PROTEIN 6
(Homo
sapiens)		5 / 12GLY A 339
GLN A 411
LEU A 359
ILE A 426
PHE A 428
NAG  A 701 (-3.0A)
None
None
None
None
1.37A21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_2
(GLUCOCORTICOID
RECEPTOR)		2qym PHOSPHODIESTERASE 4C
(Homo
sapiens)		4 / 6MET A 408
LEU A 405
MET A 399
GLN A 430
None
1.19A21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_2
(GLUCOCORTICOID
RECEPTOR)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		4 / 6MET A 452
LEU A 449
MET A 443
GLN A 474
None
1.45A20.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNO_A_DEXA784_2
(GLUCOCORTICOID
RECEPTOR)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		4 / 6LEU A 563
TRP A 600
MET A 604
TYR A 735
MOF  A 801 (-3.9A)
None
None
MOF  A 801 (-4.8A)
0.76A92.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNO_A_DEXA784_2
(GLUCOCORTICOID
RECEPTOR)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		4 / 6MET A 560
LEU A 563
TRP A 600
MET A 604
MOF  A 801 (-3.9A)
MOF  A 801 (-3.9A)
None
None
0.22A92.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_2
(GLUCOCORTICOID
RECEPTOR)		5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER
(Homo
sapiens)		4 / 6MET A 528
LEU A 529
TRP A 541
GLN A 141
None
1.32A18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_2
(GLUCOCORTICOID
RECEPTOR)		5l3x NEGATIVE ELONGATION
FACTOR A
NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens)		4 / 6MET B 245
TRP A  89
GLN B 242
TYR B 238
None
1.44A23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		1e33 ARYLSULFATASE A
(Homo
sapiens)		5 / 12GLY P 119
VAL P 107
LEU P 340
THR P 274
PHE P 219
None
1.28A20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		1jpl ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA3
(Homo
sapiens)		5 / 12ASN A  75
GLY A  77
VAL A  84
LEU A  69
ILE A  30
None
1.32A21.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		5 / 12ASN A 705
GLN A 711
MET A 742
ARG A 752
LEU A 873
BHM  A   1 (-3.6A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
BHM  A   1 (-4.4A)
0.83A50.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		5 / 12ASN A 705
GLN A 711
MET A 742
LEU A 873
PHE A 891
BHM  A   1 (-3.6A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-4.4A)
None
1.01A50.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		5 / 12ASN A 705
GLY A 708
GLN A 711
MET A 742
ARG A 752
BHM  A   1 (-3.6A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
0.78A50.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		5 / 12ASN A 705
GLY A 708
GLN A 711
MET A 742
PHE A 891
BHM  A   1 (-3.6A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
None
0.93A50.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		5 / 12GLN A 711
MET A 742
VAL A 746
ARG A 752
LEU A 873
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 (-3.8A)
BHM  A   1 (-4.4A)
0.73A50.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		5 / 12GLY A 708
GLN A 711
MET A 742
VAL A 746
ARG A 752
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 (-3.8A)
0.59A50.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		2jjd RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE EPSILON
(Homo
sapiens)		5 / 12ASN A 451
GLY A 446
VAL A 468
ARG A 669
LEU A 470
None
1.25A16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		2ksb SUBSTANCE-P RECEPTOR
(Homo
sapiens)		5 / 12VAL A 252
MET A 249
LEU A 308
CYH A 306
ILE A  56
None
1.38A20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		2wkp NPH1-1, RAS-RELATED
C3 BOTULINUM TOXIN
SUBSTRATE 1
(Avena
sativa;
Homo
sapiens)		5 / 12GLY A 555
VAL A 551
LEU A 563
CYH A 561
ILE A 576
GTP  A1724 (-3.6A)
None
None
GTP  A1724 (-3.4A)
None
1.36A22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		3a98 ENGULFMENT AND CELL
MOTILITY PROTEIN 1
(Homo
sapiens)		5 / 12VAL B 610
LEU B 579
CYH B 577
THR B 560
PHE B 562
None
1.39A23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		3b6u KINESIN-LIKE PROTEIN
KIF3B
(Homo
sapiens)		5 / 12ASN A 242
GLY A  90
VAL A  10
LEU A 305
ILE A 218
None
1.37A20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		3c6g CYTOCHROME P450 2R1
(Homo
sapiens)		5 / 12GLY A  42
LEU A  81
THR A 398
ILE A 394
PHE A  39
None
1.00A19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		3f70 LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE 2
PROTEIN
(Homo
sapiens)		5 / 12GLY A 572
LEU A 601
CYH A 554
ILE A 568
PHE A 570
None
None
MLZ  A  20 ( 4.1A)
None
MLZ  A  20 (-4.0A)
1.33A21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		3feo MBT
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		5 / 12GLY A 399
LEU A 428
CYH A 381
ILE A 395
PHE A 397
None
1.24A19.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)		8 / 12ASN A 719
GLY A 722
MET A 756
ARG A 766
LEU A 887
CYH A 891
THR A 894
PHE A 905
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.0A)
WOW  A   1 (-3.5A)
WOW  A   1 (-3.9A)
WOW  A   1 (-4.6A)
0.66A54.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)		8 / 12GLY A 722
GLN A 725
MET A 756
VAL A 760
ARG A 766
MET A 801
LEU A 887
CYH A 891
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-4.0A)
WOW  A   1 (-3.5A)
1.04A54.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)		8 / 12GLY A 722
MET A 756
VAL A 760
ARG A 766
MET A 801
LEU A 887
CYH A 891
THR A 894
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-4.0A)
WOW  A   1 (-3.5A)
WOW  A   1 (-3.9A)
0.88A54.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		4eyc CATHELICIDIN
ANTIMICROBIAL
PEPTIDE
(Homo
sapiens)		5 / 12ASN A  47
GLY A  45
VAL A  39
LEU A  58
THR A  84
None
1.16A19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		4nnd TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 18
(Homo
sapiens)		5 / 12ASN A  56
GLY A  51
VAL A  73
ARG A 271
LEU A  75
None
1.32A20.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		11 / 12ASN A 564
GLY A 567
GLN A 570
MET A 601
ARG A 611
MET A 646
LEU A 732
CYH A 736
THR A 739
ILE A 747
PHE A 749
MOF  A 801 (-3.0A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.2A)
MOF  A 801 (-4.4A)
MOF  A 801 ( 4.2A)
MOF  A 801 (-3.7A)
MOF  A 801 (-3.9A)
MOF  A 801 ( 4.4A)
MOF  A 801 (-4.4A)
0.63A91.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		7 / 12ASN A 564
GLY A 568
MET A 601
CYH A 736
THR A 739
ILE A 747
PHE A 749
MOF  A 801 (-3.0A)
None
MOF  A 801 (-3.7A)
MOF  A 801 (-3.7A)
MOF  A 801 (-3.9A)
MOF  A 801 ( 4.4A)
MOF  A 801 (-4.4A)
0.91A91.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		8 / 12ASN A 770
GLN A 776
MET A 807
ARG A 817
LEU A 938
CYH A 942
THR A 945
PHE A 956
CV7  A1987 (-3.1A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-4.0A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.7A)
0.33A53.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		5 / 12ASN A 770
GLY A 774
MET A 807
THR A 945
PHE A 956
CV7  A1987 (-3.1A)
None
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.7A)
1.12A53.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		5 / 12GLN A 776
MET A 807
ARG A 817
MET A 852
LEU A 938
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.7A)
CV7  A1987 ( 3.9A)
0.96A53.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		5a8z NEUTROPHIL ELASTASE
(Homo
sapiens)		5 / 12GLN A 233
VAL A 181
LEU A 199
THR A  45
ILE A  47
None
1.38A19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens)		5 / 12ASN A  98
GLY A  76
GLN A 318
LEU A 672
ILE A 100
None
1.32A10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		5epg ALDEHYDE OXIDASE
(Homo
sapiens)		5 / 12GLY A  50
GLN A 348
MET A 121
CYH A 149
ILE A1238
FES  A3002 (-3.4A)
None
None
FES  A3001 (-2.1A)
None
1.39A12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		5hde TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 12
(Homo
sapiens)		5 / 12ASN A  58
GLY A  53
VAL A  75
ARG A 273
LEU A  77
None
1.36A20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		5hzh RAS-RELATED C3
BOTULINUM TOXIN
SUBSTRATE
1,NPH1-1,RAS-RELATED
C3 BOTULINUM TOXIN
SUBSTRATE 1
(Avena
sativa;
Homo
sapiens)		5 / 12GLY A  12
VAL A   8
LEU A  20
CYH A  18
ILE A  33
GTP  A 401 (-3.5A)
None
None
GTP  A 401 (-3.4A)
None
1.32A21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens)		5 / 12ASN A 273
GLY A 268
VAL A 290
ARG A 501
LEU A 292
None
1.34A18.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		8 / 12ASN A 770
GLN A 776
MET A 807
ARG A 817
LEU A 938
CYH A 942
THR A 945
PHE A 956
ECV  A1101 (-3.1A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 ( 4.3A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
ECV  A1101 ( 4.7A)
0.49A47.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		6 / 12ASN A 770
GLY A 774
GLN A 776
MET A 807
THR A 945
PHE A 956
ECV  A1101 (-3.1A)
None
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-3.2A)
ECV  A1101 ( 4.7A)
1.22A47.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		7fab IGG1-LAMBDA NEW FAB
(HEAVY CHAIN)
(Homo
sapiens)		5 / 12MET H  69
VAL H  67
ARG H  64
LEU H  80
ILE H 104
None
1.39A20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_2
(GLUCOCORTICOID
RECEPTOR)		2qym PHOSPHODIESTERASE 4C
(Homo
sapiens)		4 / 6MET A 408
LEU A 405
MET A 399
GLN A 430
None
1.21A21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_2
(GLUCOCORTICOID
RECEPTOR)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		4 / 6MET A 452
LEU A 449
MET A 443
GLN A 474
None
1.47A20.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNP_A_DEXA784_2
(GLUCOCORTICOID
RECEPTOR)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		4 / 6LEU A 563
TRP A 600
MET A 604
TYR A 735
MOF  A 801 (-3.9A)
None
None
MOF  A 801 (-4.8A)
0.74A91.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNP_A_DEXA784_2
(GLUCOCORTICOID
RECEPTOR)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		4 / 6MET A 560
LEU A 563
TRP A 600
MET A 604
MOF  A 801 (-3.9A)
MOF  A 801 (-3.9A)
None
None
0.21A91.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_2
(GLUCOCORTICOID
RECEPTOR)		5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER
(Homo
sapiens)		4 / 6MET A 528
LEU A 529
TRP A 541
GLN A 141
None
1.35A18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_2
(GLUCOCORTICOID
RECEPTOR)		5l3x NEGATIVE ELONGATION
FACTOR A
NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens)		4 / 6MET B 245
TRP A  89
GLN B 242
TYR B 238
None
1.42A23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_2
(GLUCOCORTICOID
RECEPTOR)		5l3x NEGATIVE ELONGATION
FACTOR A
NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens)		4 / 6MET B 245
TRP A  89
MET A  92
GLN B 242
None
1.48A23.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UDA_A_DEXA1985_1
(MINERALOCORTICOID
RECEPTOR)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		8 / 12LEU A 701
ASN A 705
GLN A 711
MET A 742
ARG A 752
MET A 780
LEU A 873
PHE A 891
None
BHM  A   1 (-3.6A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
BHM  A   1 ( 4.3A)
BHM  A   1 (-4.4A)
None
0.96A52.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UDA_A_DEXA1985_1
(MINERALOCORTICOID
RECEPTOR)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		7 / 12LEU A 701
GLN A 711
MET A 742
ARG A 752
MET A 780
MET A 787
LEU A 873
None
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
BHM  A   1 ( 4.3A)
BHM  A   1 (-3.6A)
BHM  A   1 (-4.4A)
0.95A52.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UDA_A_DEXA1985_1
(MINERALOCORTICOID
RECEPTOR)		3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)		6 / 12GLN A 725
MET A 756
ARG A 766
MET A 801
LEU A 887
CYH A 891
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-4.0A)
WOW  A   1 (-3.5A)
0.82A55.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UDA_A_DEXA1985_1
(MINERALOCORTICOID
RECEPTOR)		3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)		8 / 12LEU A 715
ASN A 719
MET A 756
ARG A 766
MET A 801
LEU A 887
CYH A 891
PHE A 905
WOW  A   1 (-3.9A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-4.0A)
WOW  A   1 (-3.5A)
WOW  A   1 (-4.6A)
0.58A55.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UDA_A_DEXA1985_1
(MINERALOCORTICOID
RECEPTOR)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		8 / 12ASN A 564
GLN A 570
MET A 601
ARG A 611
MET A 646
LEU A 732
CYH A 736
PHE A 749
MOF  A 801 (-3.0A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.2A)
MOF  A 801 (-4.4A)
MOF  A 801 ( 4.2A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.4A)
0.62A56.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UDA_A_DEXA1985_1
(MINERALOCORTICOID
RECEPTOR)		4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		10 / 12LEU A 766
ASN A 770
ALA A 773
GLN A 776
MET A 807
ARG A 817
MET A 852
LEU A 938
CYH A 942
PHE A 956
CV7  A1987 (-3.6A)
CV7  A1987 (-3.1A)
CV7  A1987 (-3.5A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.7A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-4.0A)
CV7  A1987 ( 4.7A)
0.26A99.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UDA_A_DEXA1985_1
(MINERALOCORTICOID
RECEPTOR)		5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		7 / 12ALA A 773
GLN A 776
MET A 807
SER A 810
ARG A 817
MET A 852
LEU A 938
ECV  A1101 (-3.8A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-3.4A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.7A)
ECV  A1101 ( 4.3A)
0.93A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UDA_A_DEXA1985_1
(MINERALOCORTICOID
RECEPTOR)		5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		11 / 12LEU A 766
ASN A 770
ALA A 773
GLN A 776
MET A 807
SER A 810
ARG A 817
MET A 845
LEU A 938
CYH A 942
PHE A 956
ECV  A1101 ( 3.9A)
ECV  A1101 (-3.1A)
ECV  A1101 (-3.8A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-3.4A)
ECV  A1101 (-4.0A)
ECV  A1101 (-4.0A)
ECV  A1101 ( 4.3A)
ECV  A1101 (-4.0A)
ECV  A1101 ( 4.7A)
0.59A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		1bhd UTROPHIN
(Homo
sapiens)		4 / 6LEU A 189
TRP A 199
LEU A 211
VAL A 160
None
1.01A16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens)		4 / 6LEU A 128
LEU A 255
PHE A 254
VAL A 245
None
HBI  A 700 (-4.7A)
HBI  A 700 (-3.6A)
None
0.97A23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		1gzh TUMOR SUPPRESSOR
P53-BINDING PROTEIN
1
(Homo
sapiens)		4 / 6LEU B1819
TRP B1888
PHE B1791
THR B1894
None
1.12A22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		1h2t 80 KDA NUCLEAR CAP
BINDING PROTEIN
(Homo
sapiens)		4 / 6LEU C 566
LEU C 554
PHE C 508
VAL C 572
None
1.05A17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		1hu3 EIF4GII
(Homo
sapiens)		4 / 6LEU A 788
LEU A 794
PHE A 755
THR A 751
None
1.07A21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		1k2p TYROSINE-PROTEIN
KINASE BTK
(Homo
sapiens)		4 / 6LEU A 483
LEU A 593
PHE A 493
VAL A 529
None
0.99A22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		1z0k GTP-BINDING PROTEIN
(Homo
sapiens)		4 / 6LEU A  12
LEU A  59
PHE A 162
VAL A  87
None
1.03A20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		2fv2 RCD1 REQUIRED FOR
CELL
DIFFERENTIATION1
HOMOLOG
(Homo
sapiens)		4 / 6LEU A 103
LEU A  95
PHE A 141
THR A 145
None
0.95A23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		2fv5 ADAM 17
(Homo
sapiens)		4 / 6LEU A 251
PHE A 338
THR A 385
VAL A 402
None
None
None
541  A   1 ( 4.1A)
1.09A24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens)		4 / 6LEU A 716
TRP A 793
LEU A 688
THR A 580
None
0.85A21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		3hf8 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens)		4 / 6LEU A 115
LEU A 242
PHE A 241
VAL A 232
None
1.01A22.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)		4 / 6LEU A 718
LEU A 797
THR A 894
VAL A 903
WOW  A   1 (-4.2A)
WOW  A   1 ( 4.5A)
WOW  A   1 (-3.9A)
None
0.62A55.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		3vzb SPHINGOSINE KINASE 1
(Homo
sapiens)		4 / 6LEU A 259
PHE A 303
THR A 196
VAL A 177
None
None
SQS  A 401 ( 4.3A)
SQS  A 401 ( 4.5A)
1.09A24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		3wbg FATTY ACID-BINDING
PROTEIN, HEART
(Homo
sapiens)		4 / 6LEU A  94
LEU A 117
THR A  74
VAL A  80
None
1.06A19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		4h9p DEATH
DOMAIN-ASSOCIATED
PROTEIN 6
(Homo
sapiens)		4 / 6LEU C 290
LEU C 311
THR C 262
VAL C 267
None
1.12A21.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		5 / 6LEU A 765
LEU A 848
PHE A 941
THR A 945
VAL A 954
None
CV7  A1987 ( 4.4A)
CV7  A1987 (-4.6A)
CV7  A1987 (-3.1A)
None
0.95A99.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		6 / 6LEU A 769
TRP A 806
LEU A 848
PHE A 941
THR A 945
VAL A 954
CV7  A1987 (-4.1A)
None
CV7  A1987 ( 4.4A)
CV7  A1987 (-4.6A)
CV7  A1987 (-3.1A)
None
0.32A99.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		5edu MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HISTONE DEACETYLASE
6 CHIMERA
(Escherichia
coli;
Homo
sapiens)		4 / 6LEU B 537
LEU B 548
THR B 583
VAL B 628
None
1.08A15.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UDC_A_DEXA1778_1
(GLUCOCORTICOID
RECEPTOR)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		5 / 12GLY A 708
GLN A 711
MET A 742
ARG A 752
MET A 787
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
BHM  A   1 (-3.6A)
0.90A46.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UDC_A_DEXA1778_1
(GLUCOCORTICOID
RECEPTOR)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		6 / 12LEU A 704
ASN A 705
GLY A 708
GLN A 711
MET A 742
ARG A 752
BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
0.85A46.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UDC_A_DEXA1778_1
(GLUCOCORTICOID
RECEPTOR)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		5 / 12LEU A 704
ASN A 705
GLY A 708
GLN A 711
PHE A 891
BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
None
0.71A46.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_1
(GLUCOCORTICOID
RECEPTOR)		2bzg THIOPURINE
S-METHYLTRANSFERASE
(Homo
sapiens)		5 / 12LEU A 185
GLY A 153
TRP A 150
ARG A 226
ILE A 204
None
SAH  A1246 (-3.9A)
None
None
None
1.46A22.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UDC_A_DEXA1778_1
(GLUCOCORTICOID
RECEPTOR)		2gpv ESTROGEN-RELATED
RECEPTOR GAMMA
(Homo
sapiens)		5 / 12LEU A 268
TRP A 305
MET A 306
ARG A 316
ILE A 438
OHT  A 500 (-4.1A)
None
OHT  A 500 (-3.9A)
OHT  A 500 (-3.8A)
None
1.09A31.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_1
(GLUCOCORTICOID
RECEPTOR)		3aqi FERROCHELATASE
(Homo
sapiens)		5 / 12MET A  73
LEU A  74
THR A 136
ILE A 161
PHE A 163
None
1.49A22.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UDC_A_DEXA1778_1
(GLUCOCORTICOID
RECEPTOR)		3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)		6 / 12ASN A 719
TRP A 755
MET A 756
MET A 801
THR A 894
PHE A 905
WOW  A   1 (-3.3A)
None
WOW  A   1 ( 4.1A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.9A)
WOW  A   1 (-4.6A)
1.25A49.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UDC_A_DEXA1778_1
(GLUCOCORTICOID
RECEPTOR)		3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)		5 / 12GLY A 722
GLN A 725
MET A 756
ARG A 766
MET A 801
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
0.98A49.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UDC_A_DEXA1778_1
(GLUCOCORTICOID
RECEPTOR)		3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)		8 / 12LEU A 718
ASN A 719
GLY A 722
MET A 756
ARG A 766
MET A 801
THR A 894
PHE A 905
WOW  A   1 (-4.2A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.9A)
WOW  A   1 (-4.6A)
0.81A49.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UDC_A_DEXA1778_1
(GLUCOCORTICOID
RECEPTOR)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		7 / 12ASN A 564
GLY A 568
GLN A 570
TRP A 600
MET A 601
ILE A 747
PHE A 749
MOF  A 801 (-3.0A)
None
MOF  A 801 (-2.9A)
None
MOF  A 801 (-3.7A)
MOF  A 801 ( 4.4A)
MOF  A 801 (-4.4A)
1.13A96.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UDC_A_DEXA1778_1
(GLUCOCORTICOID
RECEPTOR)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		12 / 12MET A 560
LEU A 563
ASN A 564
GLY A 567
GLN A 570
TRP A 600
MET A 601
ARG A 611
MET A 646
THR A 739
ILE A 747
PHE A 749
MOF  A 801 (-3.9A)
MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
None
MOF  A 801 (-3.7A)
MOF  A 801 (-4.2A)
MOF  A 801 (-4.4A)
MOF  A 801 (-3.9A)
MOF  A 801 ( 4.4A)
MOF  A 801 (-4.4A)
0.52A96.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UDC_A_DEXA1778_1
(GLUCOCORTICOID
RECEPTOR)		4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		6 / 12ASN A 770
GLY A 774
GLN A 776
TRP A 806
THR A 945
PHE A 956
CV7  A1987 (-3.1A)
None
CV7  A1987 (-3.0A)
None
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.7A)
1.28A51.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UDC_A_DEXA1778_1
(GLUCOCORTICOID
RECEPTOR)		4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		9 / 12LEU A 769
ASN A 770
GLN A 776
TRP A 806
MET A 807
ARG A 817
MET A 852
THR A 945
PHE A 956
CV7  A1987 (-4.1A)
CV7  A1987 (-3.1A)
CV7  A1987 (-3.0A)
None
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.7A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.7A)
0.64A51.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UDC_A_DEXA1778_1
(GLUCOCORTICOID
RECEPTOR)		5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		6 / 12ASN A 770
GLY A 774
GLN A 776
TRP A 806
THR A 945
PHE A 956
ECV  A1101 (-3.1A)
None
ECV  A1101 (-2.9A)
None
ECV  A1101 (-3.2A)
ECV  A1101 ( 4.7A)
1.28A41.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UDC_A_DEXA1778_1
(GLUCOCORTICOID
RECEPTOR)		5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		5 / 12GLN A 776
TRP A 806
MET A 807
ARG A 817
MET A 852
ECV  A1101 (-2.9A)
None
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.7A)
1.24A41.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UDC_A_DEXA1778_1
(GLUCOCORTICOID
RECEPTOR)		5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		8 / 12LEU A 769
ASN A 770
GLN A 776
TRP A 806
MET A 807
ARG A 817
THR A 945
PHE A 956
ECV  A1101 (-4.7A)
ECV  A1101 (-3.1A)
ECV  A1101 (-2.9A)
None
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
ECV  A1101 ( 4.7A)
0.56A41.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_1
(GLUCOCORTICOID
RECEPTOR)		5yjh PERIOSTIN
(Homo
sapiens)		5 / 12MET A 174
LEU A 175
GLY A 214
ILE A 170
PHE A 135
None
None
CL  A 711 ( 4.4A)
None
None
0.98A15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_1
(GLUCOCORTICOID
RECEPTOR)		6au8 GOLGI TO ER TRAFFIC
PROTEIN 4 HOMOLOG
LARGE PROLINE-RICH
PROTEIN BAG6
(Homo
sapiens)		5 / 12LEU A 236
GLN C1023
THR A 220
ILE A 226
PHE A 232
None
1.46A22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		1fch PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens)		3 / 3MET A 370
GLN A 384
TYR A 283
None
1.02A21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		1kcg ULBP3 PROTEIN
(Homo
sapiens)		3 / 3MET C 179
GLN C  60
TYR C  62
GSH  C 999 (-4.6A)
None
None
1.07A18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		2dt7 SPLICING FACTOR 3
SUBUNIT 1
(Homo
sapiens)		3 / 3MET B 186
GLN B 194
TYR B 193
None
0.81A17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens)		3 / 3MET A 325
GLN A 320
TYR A 299
None
0.72A17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		2hgn HETEROGENEOUS
NUCLEAR
RIBONUCLEOPROTEIN F
(Homo
sapiens)		3 / 3MET A 293
GLN A 353
TYR A 298
None
0.97A17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		2l03 LY-6/NEUROTOXIN-LIKE
PROTEIN 1
(Homo
sapiens)		3 / 3MET A  18
GLN A  68
TYR A  26
None
1.07A12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		2mpc PYRIN
(Homo
sapiens)		3 / 3MET A  53
GLN A  34
TYR A  65
None
1.06A16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		2qbx EPHRIN TYPE-B
RECEPTOR 2
(Homo
sapiens)		3 / 3MET A  44
GLN A 187
TYR A 122
None
1.07A19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens)		3 / 3MET A 408
GLN A 527
TYR A 561
None
0.98A14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		3sqd PAX-INTERACTING
PROTEIN 1
(Homo
sapiens)		3 / 3MET A1013
GLN A1006
TYR A 979
None
1.01A21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		4fys AMINOPEPTIDASE N
(Homo
sapiens)		3 / 3MET A 444
GLN A 546
TYR A 582
None
1.00A14.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		3 / 3MET A 604
GLN A 760
TYR A 598
None
1.03A96.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		5h08 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA
(Homo
sapiens)		3 / 3MET A1825
GLN A1898
TYR A1864
None
1.09A20.00