POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		1kq0 METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens)		5 / 12PHE A 219
ALA A 362
HIS A 331
HIS A 339
ASP A 251
MED  A 601 ( 3.9A)
ZN  A 480 ( 3.7A)
ZN  A 480 ( 3.4A)
MED  A 601 (-3.3A)
ZN  A 479 ( 1.9A)
1.21A19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		1zef ALKALINE PHOSPHATASE
(Homo
sapiens)		5 / 12HIS A 320
HIS A 317
ASP A 273
HIS A 432
ASP A 316
 ZN  A 901 ( 3.3A)
PHE  A 802 (-4.0A)
None
ZN  A 901 ( 3.2A)
ZN  A 901 ( 1.9A)
1.13A20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		2adu METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens)		5 / 12PHE A 219
ALA A 362
HIS A 331
HIS A 339
ASP A 251
R20  A 906 ( 3.8A)
CO  A 502 ( 3.8A)
CO  A 502 ( 3.2A)
R20  A 906 (-4.0A)
CO  A 501 ( 1.9A)
1.24A22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		3e0l GUANINE DEAMINASE
(Homo
sapiens)		6 / 12HIS A  82
HIS A  84
HIS A 238
GLU A 241
HIS A 277
ASP A 328
 ZN  A1452 (-3.3A)
ZN  A1452 (-3.1A)
ZN  A1452 (-3.2A)
None
None
ZN  A1452 (-2.8A)
0.64A23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		3lgg ADENOSINE DEAMINASE
CECR1
(Homo
sapiens)		8 / 12HIS A  86
HIS A  88
ASP A  89
HIS A 330
GLU A 333
HIS A 358
ASP A 415
ASP A 416
 ZN  A 512 (-3.4A)
CFE  A 513 ( 3.3A)
CFE  A 513 (-3.0A)
ZN  A 512 ( 3.5A)
CFE  A 513 (-3.0A)
CFE  A 513 ( 4.3A)
CFE  A 513 ( 2.8A)
CFE  A 513 (-2.8A)
0.86A21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		3lgg ADENOSINE DEAMINASE
CECR1
(Homo
sapiens)		6 / 12HIS A  86
HIS A  88
PHE A 181
HIS A 330
ASP A 415
ASP A 416
 ZN  A 512 (-3.4A)
CFE  A 513 ( 3.3A)
CFE  A 513 (-4.8A)
ZN  A 512 ( 3.5A)
CFE  A 513 ( 2.8A)
CFE  A 513 (-2.8A)
1.22A21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		3lgg ADENOSINE DEAMINASE
CECR1
(Homo
sapiens)		9 / 12HIS A  86
HIS A  88
PHE A 181
PHE A 185
HIS A 330
GLU A 333
HIS A 358
ASP A 415
ASP A 416
 ZN  A 512 (-3.4A)
CFE  A 513 ( 3.3A)
CFE  A 513 (-4.8A)
CFE  A 513 ( 3.7A)
ZN  A 512 ( 3.5A)
CFE  A 513 (-3.0A)
CFE  A 513 ( 4.3A)
CFE  A 513 ( 2.8A)
CFE  A 513 (-2.8A)
0.60A21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		3lgg ADENOSINE DEAMINASE
CECR1
(Homo
sapiens)		6 / 12HIS A  86
PHE A 420
PHE A 181
HIS A 358
ASP A 415
ASP A 416
 ZN  A 512 (-3.4A)
None
CFE  A 513 (-4.8A)
CFE  A 513 ( 4.3A)
CFE  A 513 ( 2.8A)
CFE  A 513 (-2.8A)
1.31A21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		4bhi GAMMA-BUTYROBETAINE
DIOXYGENASE
(Homo
sapiens)		5 / 12HIS A 202
ASP A 261
ALA A 193
HIS A 347
ASP A 204
 ZN  A 402 ( 3.3A)
RUJ  A 401 ( 4.7A)
OGA  A 400 (-3.1A)
ZN  A 402 ( 3.3A)
ZN  A 402 (-2.6A)
1.26A22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		4igm 2-AMINO-3-CARBOXYMUC
ONATE-6-SEMIALDEHYDE
DECARBOXYLASE
(Homo
sapiens)		5 / 12HIS A   6
HIS A   8
HIS A 174
HIS A 224
ASP A 291
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.5A)
ZN  A 401 (-3.3A)
None
ZN  A 401 (-3.0A)
0.98A21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		4zyo ACYL-COA DESATURASE
(Homo
sapiens)		5 / 12HIS A 161
HIS A 120
ALA A 310
HIS A 301
HIS A 302
 ZN  A 401 (-3.3A)
ZN  A 401 ( 3.3A)
None
ZN  A 401 (-3.4A)
ZN  A 402 (-3.5A)
1.16A22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		1kq0 METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens)		5 / 12PHE A 219
ALA A 362
HIS A 331
HIS A 339
ASP A 251
MED  A 601 ( 3.9A)
ZN  A 480 ( 3.7A)
ZN  A 480 ( 3.4A)
MED  A 601 (-3.3A)
ZN  A 479 ( 1.9A)
1.21A19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		3e0l GUANINE DEAMINASE
(Homo
sapiens)		6 / 12HIS A  84
LEU A 103
HIS A 238
GLU A 241
HIS A 277
ASP A 328
 ZN  A1452 (-3.1A)
None
ZN  A1452 (-3.2A)
None
None
ZN  A1452 (-2.8A)
0.79A23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		3e0l GUANINE DEAMINASE
(Homo
sapiens)		5 / 12LEU A  99
HIS A 238
GLU A 241
HIS A 277
ASP A 328
None
ZN  A1452 (-3.2A)
None
None
ZN  A1452 (-2.8A)
1.19A23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		3lgg ADENOSINE DEAMINASE
CECR1
(Homo
sapiens)		7 / 12HIS A  88
ASP A  89
HIS A 330
GLU A 333
HIS A 358
ASP A 415
ASP A 416
CFE  A 513 ( 3.3A)
CFE  A 513 (-3.0A)
ZN  A 512 ( 3.5A)
CFE  A 513 (-3.0A)
CFE  A 513 ( 4.3A)
CFE  A 513 ( 2.8A)
CFE  A 513 (-2.8A)
0.95A21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		3lgg ADENOSINE DEAMINASE
CECR1
(Homo
sapiens)		5 / 12HIS A  88
LEU A 389
PHE A 181
HIS A 330
ASP A 416
CFE  A 513 ( 3.3A)
None
CFE  A 513 (-4.8A)
ZN  A 512 ( 3.5A)
CFE  A 513 (-2.8A)
1.31A21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		3lgg ADENOSINE DEAMINASE
CECR1
(Homo
sapiens)		7 / 12HIS A  88
PHE A 181
PHE A 185
HIS A 330
HIS A 358
ASP A 415
ASP A 416
CFE  A 513 ( 3.3A)
CFE  A 513 (-4.8A)
CFE  A 513 ( 3.7A)
ZN  A 512 ( 3.5A)
CFE  A 513 ( 4.3A)
CFE  A 513 ( 2.8A)
CFE  A 513 (-2.8A)
0.67A21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		3lgg ADENOSINE DEAMINASE
CECR1
(Homo
sapiens)		7 / 12HIS A  88
PHE A 185
HIS A 330
GLU A 333
HIS A 358
ASP A 415
ASP A 416
CFE  A 513 ( 3.3A)
CFE  A 513 ( 3.7A)
ZN  A 512 ( 3.5A)
CFE  A 513 (-3.0A)
CFE  A 513 ( 4.3A)
CFE  A 513 ( 2.8A)
CFE  A 513 (-2.8A)
0.45A21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		5wea PROTEIN ARGONAUTE-2
(Homo
sapiens)		5 / 12HIS A 764
PHE A 676
LEU A 768
GLU A 745
HIS A 742
None
1.44A12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens)		4 / 5LEU A 474
SER A 499
LEU A 501
GLY A 549
None
1.04A21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		3c5w PP2A-SPECIFIC
METHYLESTERASE PME-1
(Homo
sapiens)		4 / 5HIS P 349
LEU P 305
LEU P 112
GLY P 159
None
0.95A21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		3c5w PP2A-SPECIFIC
METHYLESTERASE PME-1
(Homo
sapiens)		4 / 5HIS P 352
LEU P 112
LEU P 177
GLY P 158
None
1.13A21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM
(Homo
sapiens)		4 / 5LEU A 139
SER A 808
LEU A 683
GLY A 485
NBG  A   1 ( 4.2A)
None
None
None
1.05A17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		3d3k ENHANCER OF
MRNA-DECAPPING
PROTEIN 3
(Homo
sapiens)		4 / 5HIS A 287
LEU A 299
SER A 495
GLY A 480
None
1.00A22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens)		4 / 5HIS A 244
LEU A 201
SER A 221
LEU A 224
None
1.07A21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		4cby HISTONE DEACETYLASE
4
(Homo
sapiens)		4 / 5HIS A 803
LEU A 943
SER A 931
GLY A 975
KEE  A2033 (-4.0A)
None
None
KEE  A2033 ( 4.9A)
1.01A23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		4er6 HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC
(Homo
sapiens)		4 / 5HIS A  86
LEU A  98
LEU A 106
GLY A 210
None
1.06A20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		4lk3 UDP-GLUCURONIC ACID
DECARBOXYLASE 1
(Homo
sapiens)		4 / 5LEU A 176
SER A 201
LEU A 199
GLY A 234
None
1.05A23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		5dsy POLY [ADP-RIBOSE]
POLYMERASE 2
(Homo
sapiens)		4 / 5LEU A 541
SER A 501
LEU A 479
GLY A 504
None
1.05A20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens)		4 / 5LEU B 606
SER B 658
LEU B 463
GLY B 489
None
1.14A18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		5xst POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens)		4 / 5LEU A 323
SER A 286
LEU A 265
GLY A 289
None
1.09A15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		6cwx RIBONUCLEASE P
PROTEIN SUBUNIT P25
(Homo
sapiens)		4 / 5LEU B 135
SER B  44
LEU B  49
GLY B  69
None
None
None
CME  B  70 ( 2.3A)
1.09A14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		1kcw CERULOPLASMIN
(Homo
sapiens)		5 / 12HIS A 980
HIS A1020
ALA A 166
HIS A 163
HIS A 101
 CU  A1050 (-3.0A)
CU  A1050 (-3.2A)
None
CU  A1050 (-3.3A)
CU  A1052 (-3.2A)
1.29A15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		1kq0 METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens)		5 / 12PHE A 219
ALA A 362
HIS A 331
HIS A 339
ASP A 251
MED  A 601 ( 3.9A)
ZN  A 480 ( 3.7A)
ZN  A 480 ( 3.4A)
MED  A 601 (-3.3A)
ZN  A 479 ( 1.9A)
1.19A19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		2adu METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens)		5 / 12PHE A 219
ALA A 362
HIS A 331
HIS A 339
ASP A 251
R20  A 906 ( 3.8A)
CO  A 502 ( 3.8A)
CO  A 502 ( 3.2A)
R20  A 906 (-4.0A)
CO  A 501 ( 1.9A)
1.21A22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		3e0l GUANINE DEAMINASE
(Homo
sapiens)		6 / 12HIS A  82
HIS A  84
HIS A 238
GLU A 241
HIS A 277
ASP A 328
 ZN  A1452 (-3.3A)
ZN  A1452 (-3.1A)
ZN  A1452 (-3.2A)
None
None
ZN  A1452 (-2.8A)
0.56A23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		3lgg ADENOSINE DEAMINASE
CECR1
(Homo
sapiens)		8 / 12HIS A  86
HIS A  88
ASP A  89
HIS A 330
GLU A 333
HIS A 358
ASP A 415
ASP A 416
 ZN  A 512 (-3.4A)
CFE  A 513 ( 3.3A)
CFE  A 513 (-3.0A)
ZN  A 512 ( 3.5A)
CFE  A 513 (-3.0A)
CFE  A 513 ( 4.3A)
CFE  A 513 ( 2.8A)
CFE  A 513 (-2.8A)
0.82A21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		3lgg ADENOSINE DEAMINASE
CECR1
(Homo
sapiens)		6 / 12HIS A  86
HIS A  88
PHE A 181
HIS A 330
ASP A 415
ASP A 416
 ZN  A 512 (-3.4A)
CFE  A 513 ( 3.3A)
CFE  A 513 (-4.8A)
ZN  A 512 ( 3.5A)
CFE  A 513 ( 2.8A)
CFE  A 513 (-2.8A)
1.17A21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		3lgg ADENOSINE DEAMINASE
CECR1
(Homo
sapiens)		9 / 12HIS A  86
HIS A  88
PHE A 181
PHE A 185
HIS A 330
GLU A 333
HIS A 358
ASP A 415
ASP A 416
 ZN  A 512 (-3.4A)
CFE  A 513 ( 3.3A)
CFE  A 513 (-4.8A)
CFE  A 513 ( 3.7A)
ZN  A 512 ( 3.5A)
CFE  A 513 (-3.0A)
CFE  A 513 ( 4.3A)
CFE  A 513 ( 2.8A)
CFE  A 513 (-2.8A)
0.59A21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		3lgg ADENOSINE DEAMINASE
CECR1
(Homo
sapiens)		6 / 12HIS A  86
PHE A 420
PHE A 181
HIS A 358
ASP A 415
ASP A 416
 ZN  A 512 (-3.4A)
None
CFE  A 513 (-4.8A)
CFE  A 513 ( 4.3A)
CFE  A 513 ( 2.8A)
CFE  A 513 (-2.8A)
1.28A21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		4bhi GAMMA-BUTYROBETAINE
DIOXYGENASE
(Homo
sapiens)		5 / 12HIS A 202
ASP A 261
ALA A 193
HIS A 347
ASP A 204
 ZN  A 402 ( 3.3A)
RUJ  A 401 ( 4.7A)
OGA  A 400 (-3.1A)
ZN  A 402 ( 3.3A)
ZN  A 402 (-2.6A)
1.25A22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		4igm 2-AMINO-3-CARBOXYMUC
ONATE-6-SEMIALDEHYDE
DECARBOXYLASE
(Homo
sapiens)		5 / 12HIS A   6
HIS A   8
HIS A 174
HIS A 224
ASP A 291
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.5A)
ZN  A 401 (-3.3A)
None
ZN  A 401 (-3.0A)
0.90A21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		4zyo ACYL-COA DESATURASE
(Homo
sapiens)		5 / 12HIS A 161
HIS A 120
ALA A 310
HIS A 301
HIS A 302
 ZN  A 401 (-3.3A)
ZN  A 401 ( 3.3A)
None
ZN  A 401 (-3.4A)
ZN  A 402 (-3.5A)
1.12A22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		1i2m REGULATOR OF
CHROMOSOME
CONDENSATION 1
(Homo
sapiens)		4 / 5LEU B 220
LEU B 224
LEU B 142
GLY B 154
None
0.99A23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		1s9c PEROXISOMAL
MULTIFUNCTIONAL
ENZYME TYPE 2
(Homo
sapiens)		4 / 5LEU A  96
LEU A  94
LEU A 217
GLY A  61
None
0.83A22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		3k3n PHD FINGER PROTEIN 8
(Homo
sapiens)		4 / 5LEU A 429
LEU A 433
LEU A 393
GLY A 372
None
0.87A23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		3kv4 PHD FINGER PROTEIN 8
(Homo
sapiens)		4 / 5LEU A 429
LEU A 433
LEU A 393
GLY A 372
None
1.02A22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		4kng LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens)		4 / 5LEU A 445
LEU A 448
SER A 435
LEU A 456
None
0.97A20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		4piv FATTY ACID SYNTHASE
(Homo
sapiens)		4 / 5LEU A1134
LEU A1128
LEU A1400
GLY A1217
None
0.97A19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		5fn4 NICASTRIN
(Homo
sapiens)		4 / 5LEU A 431
LEU A 427
LEU A 441
GLY A 438
None
0.83A18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		1kq0 METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens)		5 / 12PHE A 219
ALA A 362
HIS A 331
HIS A 339
ASP A 251
MED  A 601 ( 3.9A)
ZN  A 480 ( 3.7A)
ZN  A 480 ( 3.4A)
MED  A 601 (-3.3A)
ZN  A 479 ( 1.9A)
1.28A19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		3e0l GUANINE DEAMINASE
(Homo
sapiens)		5 / 12HIS A  84
HIS A 238
GLU A 241
HIS A 277
ASP A 328
 ZN  A1452 (-3.1A)
ZN  A1452 (-3.2A)
None
None
ZN  A1452 (-2.8A)
0.48A23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		3lgg ADENOSINE DEAMINASE
CECR1
(Homo
sapiens)		8 / 12HIS A  88
ASP A  89
GLY A 300
HIS A 330
GLU A 333
HIS A 358
ASP A 415
ASP A 416
CFE  A 513 ( 3.3A)
CFE  A 513 (-3.0A)
CFE  A 513 (-3.3A)
ZN  A 512 ( 3.5A)
CFE  A 513 (-3.0A)
CFE  A 513 ( 4.3A)
CFE  A 513 ( 2.8A)
CFE  A 513 (-2.8A)
0.98A21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		3lgg ADENOSINE DEAMINASE
CECR1
(Homo
sapiens)		5 / 12HIS A  88
PHE A 181
GLY A 300
HIS A 330
ASP A 416
CFE  A 513 ( 3.3A)
CFE  A 513 (-4.8A)
CFE  A 513 (-3.3A)
ZN  A 512 ( 3.5A)
CFE  A 513 (-2.8A)
1.35A21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		3lgg ADENOSINE DEAMINASE
CECR1
(Homo
sapiens)		8 / 12HIS A  88
PHE A 181
PHE A 185
GLY A 300
HIS A 330
HIS A 358
ASP A 415
ASP A 416
CFE  A 513 ( 3.3A)
CFE  A 513 (-4.8A)
CFE  A 513 ( 3.7A)
CFE  A 513 (-3.3A)
ZN  A 512 ( 3.5A)
CFE  A 513 ( 4.3A)
CFE  A 513 ( 2.8A)
CFE  A 513 (-2.8A)
0.59A21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		3lgg ADENOSINE DEAMINASE
CECR1
(Homo
sapiens)		8 / 12HIS A  88
PHE A 185
GLY A 300
HIS A 330
GLU A 333
HIS A 358
ASP A 415
ASP A 416
CFE  A 513 ( 3.3A)
CFE  A 513 ( 3.7A)
CFE  A 513 (-3.3A)
ZN  A 512 ( 3.5A)
CFE  A 513 (-3.0A)
CFE  A 513 ( 4.3A)
CFE  A 513 ( 2.8A)
CFE  A 513 (-2.8A)
0.41A21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		3vpo RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2
(Homo
sapiens)		5 / 12HIS A 172
PHE A 236
PHE A 240
GLY A 267
HIS A 269
None
None
None
None
FE  A 402 (-3.3A)
1.28A18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		4djn RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2 B
(Homo
sapiens)		5 / 12HIS A 134
PHE A 198
GLY A 229
HIS A 231
ASP A 100
None
1.28A21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		4djn RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2 B
(Homo
sapiens)		5 / 12HIS A 134
PHE A 198
PHE A 202
GLY A 229
HIS A 231
None
1.34A21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		4qn9 N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D
(Homo
sapiens)		5 / 12ALA A 310
GLY A 309
HIS A 321
HIS A 253
ASP A 189
3PE  A 503 ( 4.7A)
None
3PE  A 503 (-3.8A)
ZN  A 501 ( 3.5A)
ZN  A 502 ( 2.5A)
1.10A21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2
(Homo
sapiens)		4 / 4HIS A 159
LEU A 355
LEU A  61
LEU A 128
COA  A1001 (-4.5A)
CSO  A  92 ( 4.6A)
None
None
1.18A21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		3ahr ERO1-LIKE PROTEIN
ALPHA
(Homo
sapiens)		4 / 4HIS A 261
LEU A  69
LEU A  65
LEU A 312
None
1.25A21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		4k8y KALLIKREIN-4
(Homo
sapiens)		4 / 4HIS A  48
LEU A 231
LEU A 212
LEU A  33
None
1.21A21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens)		4 / 4HIS A 162
LEU O 307
LEU O 275
LEU A  37
None
1.24A13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		5hpd CREB-BINDING
PROTEIN,CELLULAR
TUMOR ANTIGEN P53
FUSION PROTEIN
(Homo
sapiens;
Mus
musculus)		4 / 4HIS A1805
LEU A3025
LEU A3022
LEU A3014
 ZN  A 202 ( 3.3A)
None
None
None
1.14A17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		5l3x NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens)		4 / 4HIS B 481
LEU B 529
LEU B 497
LEU B 470
None
1.25A22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens)		4 / 4HIS A1602
LEU A1210
LEU A1259
LEU A1307
None
1.19A11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		5m3x ANGIOTENSINOGEN
(Homo
sapiens)		4 / 4HIS A  88
LEU A  80
LEU A 110
LEU A 372
None
1.16A12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		5mgv PHENYLALANINE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens)		4 / 4HIS A 195
LEU A 163
LEU A 128
LEU A  93
None
1.01A22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		5vcs ALPHA-1,6-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE
(Homo
sapiens)		4 / 4HIS A 233
LEU A 131
LEU A 134
LEU A 256
None
1.22A14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		6bhc PSEUDOPODIUM-ENRICHE
D ATYPICAL KINASE 1
(Homo
sapiens)		4 / 4HIS A1373
LEU A1381
LEU A1507
LEU A1517
None
1.22A12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		1kcw CERULOPLASMIN
(Homo
sapiens)		5 / 12HIS A 103
HIS A 161
ILE A 170
HIS A1022
HIS A 978
 CU  A1051 (-3.3A)
CU  A1051 (-3.3A)
None
CU  A1051 (-3.2A)
CU  A1052 ( 3.2A)
0.97A16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		3e0l GUANINE DEAMINASE
(Homo
sapiens)		6 / 12HIS A  82
HIS A  84
HIS A 238
GLU A 241
HIS A 277
ASP A 328
 ZN  A1452 (-3.3A)
ZN  A1452 (-3.1A)
ZN  A1452 (-3.2A)
None
None
ZN  A1452 (-2.8A)
0.45A23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		3e0l GUANINE DEAMINASE
(Homo
sapiens)		5 / 12HIS A 238
HIS A 277
GLY A 326
HIS A  82
HIS A  84
 ZN  A1452 (-3.2A)
None
None
ZN  A1452 (-3.3A)
ZN  A1452 (-3.1A)
1.12A23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		3lgg ADENOSINE DEAMINASE
CECR1
(Homo
sapiens)		10 / 12HIS A  86
HIS A  88
ASP A  89
PHE A 181
GLY A 300
HIS A 330
GLU A 333
HIS A 358
ASP A 415
ASP A 416
 ZN  A 512 (-3.4A)
CFE  A 513 ( 3.3A)
CFE  A 513 (-3.0A)
CFE  A 513 (-4.8A)
CFE  A 513 (-3.3A)
ZN  A 512 ( 3.5A)
CFE  A 513 (-3.0A)
CFE  A 513 ( 4.3A)
CFE  A 513 ( 2.8A)
CFE  A 513 (-2.8A)
0.72A25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		4igm 2-AMINO-3-CARBOXYMUC
ONATE-6-SEMIALDEHYDE
DECARBOXYLASE
(Homo
sapiens)		5 / 12HIS A   6
HIS A   8
HIS A 174
HIS A 224
ASP A 291
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.5A)
ZN  A 401 (-3.3A)
None
ZN  A 401 (-3.0A)
0.86A22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		4igm 2-AMINO-3-CARBOXYMUC
ONATE-6-SEMIALDEHYDE
DECARBOXYLASE
(Homo
sapiens)		5 / 12HIS A 174
HIS A   6
ASP A   4
GLY A 297
ASP A 265
 ZN  A 401 (-3.3A)
ZN  A 401 (-3.4A)
None
None
None
0.97A22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		1as4 ANTICHYMOTRYPSIN
(Homo
sapiens)		3 / 3LEU A  26
LEU A 137
PHE A  82
None
0.69A21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		1b47 CBL
(Homo
sapiens)		3 / 3LEU A 300
LEU A  87
PHE A 271
None
0.73A23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		1d7w MYELOPEROXIDASE
(Homo
sapiens)		3 / 3LEU C 210
LEU C 381
PHE C 233
None
0.73A19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		1hlg LIPASE, GASTRIC
(Homo
sapiens)		3 / 3LEU A 335
LEU A 326
PHE A 160
None
0.71A22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		1igr INSULIN-LIKE GROWTH
FACTOR RECEPTOR 1
(Homo
sapiens)		3 / 3LEU A  55
LEU A  95
PHE A  70
None
0.71A21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		1j0w DOWNSTREAM OF
TYROSINE KINASE 5
(Homo
sapiens)		3 / 3LEU A  40
LEU A  55
PHE A  85
None
0.58A13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		1kl9 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
SUBUNIT 1
(Homo
sapiens)		3 / 3LEU A 175
LEU A 126
PHE A 152
None
0.70A20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		1pdr HUMAN DISCS LARGE
PROTEIN
(Homo
sapiens)		3 / 3LEU A 495
LEU A 532
PHE A 493
None
0.67A14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		1uhl OXYSTEROLS RECEPTOR
LXR-ALPHA
(Homo
sapiens)		3 / 3LEU B 217
LEU B 381
PHE B 271
None
0.66A20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		1uw4 REGULATOR OF
NONSENSE TRANSCRIPTS
2
UPF3X
(Homo
sapiens)		3 / 3LEU B 910
LEU A  89
PHE B 899
None
0.67A20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		1za4 THROMBOSPONDIN 1
(Homo
sapiens)		3 / 3LEU A  89
LEU A  72
PHE A  57
None
0.68A18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		1zv4 REGULATOR OF
G-PROTEIN SIGNALING
17
(Homo
sapiens)		3 / 3LEU X 151
LEU X 163
PHE X 113
None
0.64A19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		2b4x ANTITHROMBIN-III
(Homo
sapiens)		3 / 3LEU I 335
LEU I  78
PHE I 106
None
0.57A22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		2bka TAT-INTERACTING
PROTEIN TIP30
(Homo
sapiens)		3 / 3LEU A  92
LEU A  55
PHE A  72
NDP  A 506 (-4.3A)
None
NDP  A 506 (-4.5A)
0.72A21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		2d07 G/T
MISMATCH-SPECIFIC
THYMINE DNA
GLYCOSYLASE
(Homo
sapiens)		3 / 3LEU A 181
LEU A 292
PHE A 189
None
0.71A18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		2d7i POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 10
(Homo
sapiens)		3 / 3LEU A 555
LEU A 485
PHE A 589
None
0.59A20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		2es3 THROMBOSPONDIN-1
(Homo
sapiens)		3 / 3LEU A  89
LEU A  72
PHE A  57
None
0.60A20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		2fic BRIDGING INTEGRATOR
1
(Homo
sapiens)		3 / 3LEU A  71
LEU A  79
PHE A 221
None
0.73A21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens)		3 / 3LEU A 561
LEU A  57
PHE A 559
None
0.70A18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		2hr7 INSULIN RECEPTOR
(Homo
sapiens)		3 / 3LEU A  17
LEU A  33
PHE A  46
None
None
GOL  A 610 (-4.9A)
0.58A21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		2hr7 INSULIN RECEPTOR
(Homo
sapiens)		3 / 3LEU A 368
LEU A 408
PHE A 382
None
0.72A21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		2iag PROSTACYCLIN
SYNTHASE
(Homo
sapiens)		3 / 3LEU A 214
LEU A 173
PHE A 108
None
0.72A18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens)		3 / 3LEU B 684
LEU B 638
PHE B 706
None
0.46A17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		1zef ALKALINE PHOSPHATASE
(Homo
sapiens)		5 / 12ASP A 273
LEU A  40
ALA A 154
HIS A 358
ASP A 316
None
None
SEP  A  92 ( 3.7A)
ZN  A 902 (-3.2A)
ZN  A 901 ( 1.9A)
1.31A10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		2eaq LIM DOMAIN ONLY
PROTEIN 7
(Homo
sapiens)		5 / 12ILE A1045
SER A1080
ALA A1077
GLU A1072
ASP A1054
None
1.22A20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		2kbx INTEGRIN-LINKED
PROTEIN KINASE
(Homo
sapiens)		5 / 12ASP A  68
LEU A 119
SER A  76
ALA A  74
ASP A  92
None
1.07A20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		3e0l GUANINE DEAMINASE
(Homo
sapiens)		5 / 12HIS A  84
HIS A 238
GLU A 241
HIS A 277
ASP A 328
 ZN  A1452 (-3.1A)
ZN  A1452 (-3.2A)
None
None
ZN  A1452 (-2.8A)
0.36A13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		3e0l GUANINE DEAMINASE
(Homo
sapiens)		5 / 12LEU A  99
HIS A 238
GLU A 241
HIS A 277
ASP A 328
None
ZN  A1452 (-3.2A)
None
None
ZN  A1452 (-2.8A)
1.24A13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		3lgg ADENOSINE DEAMINASE
CECR1
(Homo
sapiens)		8 / 12HIS A  88
ASP A  89
SER A 265
HIS A 330
GLU A 333
HIS A 358
ASP A 415
ASP A 416
CFE  A 513 ( 3.3A)
CFE  A 513 (-3.0A)
None
ZN  A 512 ( 3.5A)
CFE  A 513 (-3.0A)
CFE  A 513 ( 4.3A)
CFE  A 513 ( 2.8A)
CFE  A 513 (-2.8A)
1.21A12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		5y7y ARYL HYDROCARBON
RECEPTOR REPRESSOR
(Homo
sapiens)		5 / 12LEU A 268
LEU A 203
ALA A 178
HIS A 176
ASP A 196
None
1.19A12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)		1bhg BETA-GLUCURONIDASE
(Homo
sapiens)		4 / 4HIS A 570
LEU A 514
TYR A 561
GLY A 542
None
1.40A9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)		2rli SCO2 PROTEIN
HOMOLOG,
MITOCHONDRIAL
(Homo
sapiens)		4 / 4HIS A 257
LEU A 144
TYR A 127
GLY A 242
None
1.20A18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)		3t6g SH2
DOMAIN-CONTAINING
PROTEIN 3C
BREAST CANCER
ANTI-ESTROGEN
RESISTANCE PROTEIN 1
(Homo
sapiens;
Homo
sapiens)		4 / 4HIS B 790
LEU A 469
TYR B 747
GLY B 796
None
1.34A18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)		4m7f FIBRINOGEN C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		4 / 4HIS A 415
LEU A 447
TYR A 445
GLY A 442
BM3  A 503 (-3.8A)
None
None
None
1.34A14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		1zef ALKALINE PHOSPHATASE
(Homo
sapiens)		5 / 12ASP A 273
LEU A  40
ALA A 154
HIS A 358
ASP A 316
None
None
SEP  A  92 ( 3.7A)
ZN  A 902 (-3.2A)
ZN  A 901 ( 1.9A)
1.27A10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		2eaq LIM DOMAIN ONLY
PROTEIN 7
(Homo
sapiens)		5 / 12ILE A1045
SER A1080
ALA A1077
GLU A1072
ASP A1054
None
1.22A20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		2kbx INTEGRIN-LINKED
PROTEIN KINASE
(Homo
sapiens)		5 / 12ASP A  68
LEU A 119
SER A  76
ALA A  74
ASP A  92
None
1.07A20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		2xk9 CHECKPOINT KINASE 2
(Homo
sapiens)		5 / 12LEU A 413
LEU A 348
ILE A 285
ALA A 334
HIS A 339
None
1.24A13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		3e0l GUANINE DEAMINASE
(Homo
sapiens)		5 / 12HIS A  84
HIS A 238
GLU A 241
HIS A 277
ASP A 328
 ZN  A1452 (-3.1A)
ZN  A1452 (-3.2A)
None
None
ZN  A1452 (-2.8A)
0.37A13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		3i6u SERINE/THREONINE-PRO
TEIN KINASE CHK2
(Homo
sapiens)		5 / 12LEU A 413
LEU A 348
ILE A 285
ALA A 334
HIS A 339
None
1.27A11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		3lgg ADENOSINE DEAMINASE
CECR1
(Homo
sapiens)		8 / 12HIS A  88
ASP A  89
SER A 265
HIS A 330
GLU A 333
HIS A 358
ASP A 415
ASP A 416
CFE  A 513 ( 3.3A)
CFE  A 513 (-3.0A)
None
ZN  A 512 ( 3.5A)
CFE  A 513 (-3.0A)
CFE  A 513 ( 4.3A)
CFE  A 513 ( 2.8A)
CFE  A 513 (-2.8A)
1.21A12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens)		5 / 12LEU A 239
LEU A 179
ILE A 115
ALA A 165
HIS A 170
None
1.30A19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		5y7y ARYL HYDROCARBON
RECEPTOR REPRESSOR
(Homo
sapiens)		5 / 12LEU A 268
LEU A 203
ALA A 178
HIS A 176
ASP A 196
None
1.21A12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		5yks SNF-RELATED
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens)		5 / 12LEU A 201
LEU A 140
ILE A  75
ALA A 126
HIS A 131
None
1.24A16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_1
(ADENOSINE DEAMINASE)		1bhg BETA-GLUCURONIDASE
(Homo
sapiens)		4 / 4HIS A 570
LEU A 514
TYR A 561
GLY A 542
None
1.40A9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_1
(ADENOSINE DEAMINASE)		2rli SCO2 PROTEIN
HOMOLOG,
MITOCHONDRIAL
(Homo
sapiens)		4 / 4HIS A 257
LEU A 144
TYR A 127
GLY A 242
None
1.21A18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_1
(ADENOSINE DEAMINASE)		4m7f FIBRINOGEN C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		4 / 4HIS A 415
LEU A 447
TYR A 445
GLY A 442
BM3  A 503 (-3.8A)
None
None
None
1.34A14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_1
(ADENOSINE DEAMINASE)		5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens)		4 / 4HIS A4187
LEU A4321
TYR A4196
GLY A4152
None
1.39A1.64