POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RZE_A_D7VA1201_1 (HISTAMINE H1 RECEPTOR, LYSOZYME CHIMERA)	1em2	MLN64 PROTEIN (Homo sapiens)	5 / 12	THR A 282 ILE A 405 ASN A 407 TRP A 404 PHE A 347	None	1.40A	18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RZE_A_D7VA1201_1 (HISTAMINE H1 RECEPTOR, LYSOZYME CHIMERA)	2nym	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2A CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	5 / 12	ASP C 131 TYR C 130 THR C 124 ILE C 123 TRP C 143	None	0.93A	21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RZE_A_D7VA1201_1 (HISTAMINE H1 RECEPTOR, LYSOZYME CHIMERA)	2pkd	SLAM FAMILY MEMBER 5 (Homo sapiens)	5 / 12	ASP A  96 TYR A  98 THR A  99 ILE A  91 ASN A  92	None	1.27A	14.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3RZE_A_D7VA1201_1 (HISTAMINE H1 RECEPTOR, LYSOZYME CHIMERA)	3pbl	D(3) DOPAMINE RECEPTOR, LYSOZYME CHIMERA (Escherichia virus T4; Homo sapiens)	6 / 12	ASP A 110 THR A 115 ILE A 118 TRP A 342 PHE A 346 TYR A 373	ETQ  A1200 (-3.5A) None None None ETQ  A1200 ( 4.5A) ETQ  A1200 (-4.4A)	0.53A	54.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3RZE_A_D7VA1201_1 (HISTAMINE H1 RECEPTOR, LYSOZYME CHIMERA)	3pds	FUSION PROTEIN BETA-2 ADRENERGIC RECEPTOR/LYSOZYME (Escherichia virus T4; Homo sapiens)	6 / 12	ASP A 113 THR A 118 ILE A 121 TRP A 286 PHE A 290 TYR A 316	ERC  A1201 (-3.7A) None None None ERC  A1201 (-4.8A) None	0.58A	55.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3RZE_A_D7VA1201_1 (HISTAMINE H1 RECEPTOR, LYSOZYME CHIMERA)	3uon	HUMAN M2 MUSCARINIC ACETYLCHOLINE, RECEPTOR T4 LYSOZYME FUSION PROTEIN (Escherichia virus T4; Homo sapiens)	5 / 12	ASP A 103 TYR A 104 SER A 107 TRP A 155 TRP A 400	QNB  A1162 (-3.1A) QNB  A1162 (-4.0A) QNB  A1162 (-3.4A) QNB  A1162 (-4.2A) QNB  A1162 (-4.7A)	1.13A	58.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3RZE_A_D7VA1201_1 (HISTAMINE H1 RECEPTOR, LYSOZYME CHIMERA)	3uon	HUMAN M2 MUSCARINIC ACETYLCHOLINE, RECEPTOR T4 LYSOZYME FUSION PROTEIN (Escherichia virus T4; Homo sapiens)	6 / 12	ASP A 103 TYR A 104 SER A 107 TRP A 155 TYR A 403 TYR A 430	QNB  A1162 (-3.1A) QNB  A1162 (-4.0A) QNB  A1162 (-3.4A) QNB  A1162 (-4.2A) QNB  A1162 (-3.9A) QNB  A1162 ( 4.8A)	0.79A	58.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RZE_A_D7VA1201_1 (HISTAMINE H1 RECEPTOR, LYSOZYME CHIMERA)	4gbr	BETA-2 ADRENERGIC RECEPTOR (Homo sapiens)	6 / 12	ASP A 113 THR A 118 ILE A 121 TRP A 258 PHE A 262 TYR A 288	CAU  A 500 (-3.0A) CAU  A 500 ( 4.7A) None None CAU  A 500 (-4.6A) CAU  A 500 (-4.6A)	0.73A	25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RZE_A_D7VA1201_1 (HISTAMINE H1 RECEPTOR, LYSOZYME CHIMERA)	4ib4	CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 2B AND E. COLI SOLUBLE CYTOCHROME B562 (Escherichia coli; Homo sapiens)	6 / 12	ASP A 135 SER A 139 THR A 140 ILE A 143 PHE A 341 TYR A 370	ERM  A2001 (-3.2A) ERM  A2001 (-3.6A) ERM  A2001 (-3.9A) None None ERM  A2001 ( 4.8A)	0.75A	27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RZE_A_D7VA1201_1 (HISTAMINE H1 RECEPTOR, LYSOZYME CHIMERA)	4ib4	CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 2B AND E. COLI SOLUBLE CYTOCHROME B562 (Escherichia coli; Homo sapiens)	6 / 12	ASP A 135 SER A 139 THR A 140 TRP A 337 PHE A 341 TYR A 370	ERM  A2001 (-3.2A) ERM  A2001 (-3.6A) ERM  A2001 (-3.9A) None None ERM  A2001 ( 4.8A)	0.69A	27.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3RZE_A_D7VA1201_1 (HISTAMINE H1 RECEPTOR, LYSOZYME CHIMERA)	4lde	LYSOZYME, BETA-2 ADRENERGIC RECEPTOR (Escherichia virus T4; Homo sapiens)	5 / 12	ASP A1113 THR A1118 TRP A1286 PHE A1290 TYR A1316	P0G  A1401 (-2.9A) None None P0G  A1401 ( 4.9A) None	0.64A	36.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RZE_A_D7VA1201_1 (HISTAMINE H1 RECEPTOR, LYSOZYME CHIMERA)	4mqt	MUSCARINIC ACETYLCHOLINE RECEPTOR M2 (Homo sapiens)	5 / 12	ASP A 103 TYR A 104 SER A 107 TRP A 155 TRP A 400	IXO  A 501 (-3.4A) IXO  A 501 (-3.7A) IXO  A 501 (-3.4A) IXO  A 501 (-3.6A) IXO  A 501 (-4.6A)	1.08A	28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RZE_A_D7VA1201_1 (HISTAMINE H1 RECEPTOR, LYSOZYME CHIMERA)	4mqt	MUSCARINIC ACETYLCHOLINE RECEPTOR M2 (Homo sapiens)	5 / 12	ASP A 103 TYR A 104 SER A 107 TRP A 155 TYR A 430	IXO  A 501 (-3.4A) IXO  A 501 (-3.7A) IXO  A 501 (-3.4A) IXO  A 501 (-3.6A) IXO  A 501 (-4.5A)	0.81A	28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RZE_A_D7VA1201_1 (HISTAMINE H1 RECEPTOR, LYSOZYME CHIMERA)	4rwa	SOLUBLE CYTOCHROME B562,DELTA-TYPE OPIOID RECEPTOR (Escherichia coli; Homo sapiens)	5 / 12	ASP A 128 TYR A 129 ILE A 136 TRP A 274 TYR A 308	None	0.62A	24.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3RZE_A_D7VA1201_1 (HISTAMINE H1 RECEPTOR, LYSOZYME CHIMERA)	5cxv	MUSCARINIC ACETYLCHOLINE RECEPTOR M1,ENDOLYSIN,MUSCARI NIC ACETYLCHOLINE RECEPTOR M1 (Escherichia virus T4; Homo sapiens)	5 / 12	ASP A 105 TYR A 106 SER A 109 TRP A 157 TRP A 378	0HK  A 501 (-3.0A) 0HK  A 501 (-3.4A) 0HK  A 501 (-3.1A) 0HK  A 501 (-4.0A) 0HK  A 501 (-4.4A)	1.24A	55.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3RZE_A_D7VA1201_1 (HISTAMINE H1 RECEPTOR, LYSOZYME CHIMERA)	5cxv	MUSCARINIC ACETYLCHOLINE RECEPTOR M1,ENDOLYSIN,MUSCARI NIC ACETYLCHOLINE RECEPTOR M1 (Escherichia virus T4; Homo sapiens)	5 / 12	ASP A 105 TYR A 106 SER A 109 TRP A 157 TYR A 408	0HK  A 501 (-3.0A) 0HK  A 501 (-3.4A) 0HK  A 501 (-3.1A) 0HK  A 501 (-4.0A) 0HK  A 501 (-4.7A)	0.77A	55.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3RZE_A_D7VA1201_1 (HISTAMINE H1 RECEPTOR, LYSOZYME CHIMERA)	5dsg	MUSCARINIC ACETYLCHOLINE RECEPTOR M4,ENDOLYSIN,ENDOLYS IN,MUSCARINIC ACETYLCHOLINE RECEPTOR M4 (Escherichia virus T4; Homo sapiens)	5 / 12	ASP A 112 TYR A 113 SER A 116 TRP A 164 TYR A 443	0HK  A1201 (-4.0A) 0HK  A1201 ( 3.2A) 0HK  A1201 (-3.3A) OLC  A1208 ( 4.0A) 0HK  A1201 (-4.5A)	0.90A	48.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RZE_A_D7VA1201_1 (HISTAMINE H1 RECEPTOR, LYSOZYME CHIMERA)	5i8o	HMM5 ANTIBODY HEAVY CHAIN HMM5 ANTIBODY LIGHT CHAIN (Homo sapiens)	5 / 12	ASP H  98 SER H 102 THR H 103 ASN H 104 TYR L  34	2F8  H 302 (-4.2A) None None None None	1.07A	17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RZE_A_D7VA1201_1 (HISTAMINE H1 RECEPTOR, LYSOZYME CHIMERA)	5jz7	MEDI578 SCFV, HEAVY CHAIN (Homo sapiens)	5 / 12	ASP C 100 SER C  95 ILE C  34 TRP C 103 TYR C  99	None	1.50A	15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RZE_A_D7VA1201_1 (HISTAMINE H1 RECEPTOR, LYSOZYME CHIMERA)	5v54	5-HYDROXYTRYPTAMINE RECEPTOR 1B,OB-1 FUSED 5-HT1B RECEPTOR,5-HYDROXYTR YPTAMINE RECEPTOR 1B (Homo sapiens; Spodoptera frugiperda)	6 / 12	ASP A 129 THR A 134 ILE A 137 TRP A 327 PHE A 331 TYR A 359	89F  A1201 (-3.3A) 89F  A1201 (-4.2A) None 89F  A1201 (-3.6A) 89F  A1201 (-4.6A) None	0.64A	14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RZE_A_D7VA1201_1 (HISTAMINE H1 RECEPTOR, LYSOZYME CHIMERA)	5wiv	D(4) DOPAMINE RECEPTOR, SOLUBLE CYTOCHROME B562 CHIMERA (Escherichia coli; Homo sapiens)	6 / 12	ASP A 115 THR A 120 ILE A 123 TRP A 407 PHE A 411 TYR A 438	AQD  A1201 (-3.3A) AQD  A1201 (-4.4A) None None AQD  A1201 (-4.6A) None	0.66A	28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RZE_A_D7VA1201_1 (HISTAMINE H1 RECEPTOR, LYSOZYME CHIMERA)	6bqh	5-HYDROXYTRYPTAMINE RECEPTOR 2C,SOLUBLE CYTOCHROME B562 (Escherichia coli; Homo sapiens)	7 / 12	ASP A 134 SER A 138 THR A 139 ILE A 142 TRP A 324 PHE A 328 TYR A 358	E2J  A1201 (-3.0A) E2J  A1201 (-3.2A) E2J  A1201 (-4.3A) E2J  A1201 (-3.5A) E2J  A1201 ( 3.7A) E2J  A1201 (-4.4A) None	0.49A	11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RZE_A_D7VA1201_1 (HISTAMINE H1 RECEPTOR, LYSOZYME CHIMERA)	6cm4	D(2) DOPAMINE RECEPTOR, ENDOLYSIN CHIMERA (Escherichia virus T4; Homo sapiens)	5 / 12	ASP A 114 THR A 119 TRP A 386 PHE A 390 TYR A 416	8NU  A2001 ( 3.0A) 8NU  A2001 ( 4.4A) 8NU  A2001 ( 3.8A) 8NU  A2001 ( 4.8A) 8NU  A2001 ( 4.9A)	0.56A	15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RZE_A_D7VA1201_1 (HISTAMINE H1 RECEPTOR, LYSOZYME CHIMERA)	6g79	5-HYDROXYTRYPTAMINE RECEPTOR 1B (Homo sapiens)	5 / 12	ASP S 129 THR S 134 TRP S 327 PHE S 331 TYR S 359	EP5  S 401 (-3.3A) EP5  S 401 (-3.8A) None EP5  S 401 (-4.7A) EP5  S 401 ( 4.9A)	0.83A	19.10