POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LBC_A_CYZA330_1
(GLUTAMINE RECEPTOR 2)		2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens)		6 / 12LYS A 516
PRO A 517
MET A 519
LEU A 768
LEU A 776
LYS A 780
None
0.81A52.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LBC_A_CYZA330_1
(GLUTAMINE RECEPTOR 2)		3hve GIGAXONIN
(Homo
sapiens)		5 / 12LEU A  48
SER A  52
LEU A 114
LYS A 118
ILE A  73
None
1.35A22.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LBC_A_CYZA330_1
(GLUTAMINE RECEPTOR 2)		3qxm GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2
(Homo
sapiens)		6 / 12LYS A 500
PRO A 501
MET A 503
LEU A 752
LEU A 760
LYS A 764
None
0.80A52.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LBC_B_CYZB329_1
(GLUTAMINE RECEPTOR 2)		2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens)		6 / 9LYS A 516
PRO A 517
MET A 519
LEU A 768
LEU A 776
LYS A 780
None
0.90A52.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LBC_B_CYZB329_1
(GLUTAMINE RECEPTOR 2)		3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens)		5 / 9PRO A 287
LEU A 294
SER A 292
LEU A 306
LYS A 429
None
1.37A19.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LBC_B_CYZB329_1
(GLUTAMINE RECEPTOR 2)		3qxm GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2
(Homo
sapiens)		6 / 9LYS A 500
PRO A 501
MET A 503
LEU A 752
LEU A 760
LYS A 764
None
0.96A52.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LBC_C_CYZC331_1
(GLUTAMINE RECEPTOR 2)		1m9i ANNEXIN VI
(Homo
sapiens)		5 / 12ILE A 500
SER A 490
LEU A 504
LEU A 485
LYS A 483
None
1.44A18.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LBC_C_CYZC331_1
(GLUTAMINE RECEPTOR 2)		2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens)		6 / 12LYS A 516
PRO A 517
MET A 519
LEU A 768
LEU A 776
LYS A 780
None
0.84A52.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LBC_C_CYZC331_1
(GLUTAMINE RECEPTOR 2)		3hve GIGAXONIN
(Homo
sapiens)		5 / 12ILE A  73
LEU A  48
SER A  52
LEU A 114
LYS A 118
None
1.48A22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LBC_C_CYZC331_1
(GLUTAMINE RECEPTOR 2)		3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens)		5 / 12PRO A 287
LEU A 294
SER A 292
LEU A 306
LYS A 429
None
1.35A19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LBC_C_CYZC331_1
(GLUTAMINE RECEPTOR 2)		3qk3 BETA-CRYSTALLIN B3
(Homo
sapiens)		5 / 12SER A  71
SER A  98
LEU A  67
LEU A 101
LYS A  55
None
1.24A20.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LBC_C_CYZC331_1
(GLUTAMINE RECEPTOR 2)		3qxm GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2
(Homo
sapiens)		6 / 12LYS A 500
PRO A 501
MET A 503
LEU A 752
LEU A 760
LYS A 764
None
0.91A52.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LBC_C_CYZC331_1
(GLUTAMINE RECEPTOR 2)		5gzg GALECTIN-8
(Homo
sapiens)		5 / 12ILE A 149
SER A 152
PRO A  24
LEU A 138
LEU A  27
None
1.44A20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LBC_C_CYZC331_1
(GLUTAMINE RECEPTOR 2)		5zal ENDORIBONUCLEASE
DICER
(Homo
sapiens)		5 / 12SER A1737
PRO A1850
SER A1852
LEU A1841
LEU A1735
None
1.27A13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H6T_A_CYZA265_1
(GLUTAMATE RECEPTOR 2)		1m9i ANNEXIN VI
(Homo
sapiens)		5 / 11SER A 490
LEU A 504
LEU A 485
LYS A 483
ILE A 500
None
1.41A18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H6T_A_CYZA265_1
(GLUTAMATE RECEPTOR 2)		2lm5 CALCIUM AND
INTEGRIN-BINDING
PROTEIN 1
(Homo
sapiens)		5 / 11SER A 145
LEU A 144
ILE A 153
SER A 147
LYS A 150
None
1.44A21.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H6T_A_CYZA265_1
(GLUTAMATE RECEPTOR 2)		2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens)		6 / 11LYS A 516
PRO A 517
MET A 519
LEU A 768
LEU A 776
LYS A 780
None
0.84A52.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H6T_A_CYZA265_1
(GLUTAMATE RECEPTOR 2)		3kq4 CUBILIN
(Homo
sapiens)		5 / 11SER B1233
LEU B1205
SER B1250
ILE B1257
SER B1254
None
1.49A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H6T_A_CYZA265_1
(GLUTAMATE RECEPTOR 2)		3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens)		5 / 11PRO A 287
LEU A 294
SER A 292
LEU A 306
LYS A 429
None
1.17A19.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H6T_A_CYZA265_1
(GLUTAMATE RECEPTOR 2)		3qxm GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2
(Homo
sapiens)		6 / 11LYS A 500
PRO A 501
MET A 503
LEU A 752
LEU A 760
LYS A 764
None
0.88A52.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H6T_A_CYZA265_1
(GLUTAMATE RECEPTOR 2)		4bmb GALECTIN-8
(Homo
sapiens)		5 / 11PRO A  24
LEU A 138
LEU A  27
ILE A 149
SER A 152
None
1.44A20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H6T_A_CYZA265_1
(GLUTAMATE RECEPTOR 2)		5gzg GALECTIN-8
(Homo
sapiens)		5 / 11PRO A  24
LEU A 138
LEU A  27
ILE A 149
SER A 152
None
1.41A20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H6T_A_CYZA265_1
(GLUTAMATE RECEPTOR 2)		5zal ENDORIBONUCLEASE
DICER
(Homo
sapiens)		5 / 11PRO A1850
SER A1852
LEU A1841
LEU A1735
SER A1737
None
1.26A13.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H6T_B_CYZB265_1
(GLUTAMATE RECEPTOR 2)		2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens)		6 / 9LYS A 516
PRO A 517
MET A 519
LEU A 768
LEU A 776
LYS A 780
None
0.84A52.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H6T_B_CYZB265_1
(GLUTAMATE RECEPTOR 2)		3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens)		5 / 9PRO A 287
LEU A 294
SER A 292
LEU A 306
LYS A 429
None
1.22A19.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H6T_B_CYZB265_1
(GLUTAMATE RECEPTOR 2)		3qxm GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2
(Homo
sapiens)		6 / 9LYS A 500
PRO A 501
MET A 503
LEU A 752
LEU A 760
LYS A 764
None
0.82A52.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H6T_C_CYZC265_1
(GLUTAMATE RECEPTOR 2)		1m9i ANNEXIN VI
(Homo
sapiens)		5 / 11ILE A 500
SER A 490
LEU A 504
LEU A 485
LYS A 483
None
1.40A18.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H6T_C_CYZC265_1
(GLUTAMATE RECEPTOR 2)		2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens)		6 / 11LYS A 516
PRO A 517
MET A 519
LEU A 768
LEU A 776
LYS A 780
None
0.76A52.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H6T_C_CYZC265_1
(GLUTAMATE RECEPTOR 2)		3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens)		5 / 11PRO A 287
LEU A 294
SER A 292
LEU A 306
LYS A 429
None
1.14A19.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H6T_C_CYZC265_1
(GLUTAMATE RECEPTOR 2)		3qxm GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2
(Homo
sapiens)		6 / 11LYS A 500
PRO A 501
MET A 503
LEU A 752
LEU A 760
LYS A 764
None
0.79A52.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H6T_C_CYZC265_1
(GLUTAMATE RECEPTOR 2)		5zal ENDORIBONUCLEASE
DICER
(Homo
sapiens)		5 / 11SER A1737
PRO A1850
SER A1852
LEU A1841
LEU A1735
None
1.22A13.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TKD_A_CYZA266_1
(GLUTAMATE RECEPTOR 2)		2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens)		6 / 9LYS A 516
PRO A 517
MET A 519
LEU A 768
LEU A 776
LYS A 780
None
0.81A53.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TKD_A_CYZA266_1
(GLUTAMATE RECEPTOR 2)		3qxm GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2
(Homo
sapiens)		6 / 9LYS A 500
PRO A 501
MET A 503
LEU A 752
LEU A 760
LYS A 764
None
0.79A52.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens)		4 / 5ILE A 256
PRO A 145
SER A 262
GLY A 257
None
1.02A20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		2dmh MYOFERLIN
(Homo
sapiens)		4 / 5ILE A  64
PRO A  65
SER A 139
GLY A  63
None
1.00A23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		2e6n STAPHYLOCOCCAL
NUCLEASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		4 / 5ILE A  41
PRO A  27
SER A  78
GLY A  82
None
1.07A15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		2eoq ZINC FINGER PROTEIN
224
(Homo
sapiens)		4 / 5ILE A  17
SER A  21
LYS A  20
GLY A  19
 ZN  A 201 ( 4.2A)
None
None
None
1.15A12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens)		4 / 5ILE A 504
PRO A 517
LYS A 747
GLY A 748
None
0.18A53.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		3qxm GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2
(Homo
sapiens)		4 / 5ILE A 488
PRO A 501
LYS A 731
GLY A 732
None
0.28A52.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens)		4 / 5ILE A 689
PRO A 536
SER A 723
GLY A 721
None
0.98A16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT
(Homo
sapiens)		4 / 5ILE A1859
SER A1189
LYS A1188
GLY A1187
None
1.08A18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		5jz7 MEDI578 SCFV, HEAVY
CHAIN
(Homo
sapiens)		4 / 5ILE C  52
PRO C  52
SER C  96
GLY C  33
None
1.17A19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 5
(Homo
sapiens)		4 / 5ILE B 482
PRO B 483
SER B 230
LYS B 233
None
1.19A18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens)		4 / 5ILE A 256
PRO A 145
SER A 262
GLY A 257
None
1.03A20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		2dmh MYOFERLIN
(Homo
sapiens)		4 / 5ILE A  64
PRO A  65
SER A 139
GLY A  63
None
0.99A23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		2e6n STAPHYLOCOCCAL
NUCLEASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		4 / 5ILE A  41
PRO A  27
SER A  78
GLY A  82
None
1.06A15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		2eoq ZINC FINGER PROTEIN
224
(Homo
sapiens)		4 / 5ILE A  17
SER A  21
LYS A  20
GLY A  19
 ZN  A 201 ( 4.2A)
None
None
None
1.15A12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		2o4x STAPHYLOCOCCAL
NUCLEASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		4 / 5ILE B 712
PRO B 698
SER B 749
GLY B 753
None
1.04A15.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens)		4 / 5ILE A 504
PRO A 517
LYS A 747
GLY A 748
None
0.17A53.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens)		4 / 5PRO A 517
SER A 746
LYS A 747
GLY A 748
None
0.67A53.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		3qxm GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2
(Homo
sapiens)		4 / 5ILE A 488
PRO A 501
LYS A 731
GLY A 732
None
0.28A52.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens)		4 / 5ILE A 689
PRO A 536
SER A 723
GLY A 721
None
0.98A16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT
(Homo
sapiens)		4 / 5ILE A1859
SER A1189
LYS A1188
GLY A1187
None
1.06A18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		5jz7 MEDI578 SCFV, HEAVY
CHAIN
(Homo
sapiens)		4 / 5ILE C  52
PRO C  52
SER C  96
GLY C  33
None
1.17A19.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TKD_B_CYZB267_2
(GLUTAMATE RECEPTOR 2)		2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens)		6 / 9LYS A 516
PRO A 517
MET A 519
LEU A 768
LEU A 776
LYS A 780
None
0.81A53.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TKD_B_CYZB267_2
(GLUTAMATE RECEPTOR 2)		3qxm GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2
(Homo
sapiens)		6 / 9LYS A 500
PRO A 501
MET A 503
LEU A 752
LEU A 760
LYS A 764
None
0.78A52.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEO_A_CYZA1302_1
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA)		2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens)		5 / 10PRO A 551
ASP A 458
PRO A 687
SER A 527
GLY A 518
None
1.21A21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEO_A_CYZA1302_1
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA)		4lot COMPLEMENT C1S
SUBCOMPONENT HEAVY
CHAIN
(Homo
sapiens)		5 / 10PRO A 358
SER A 365
ILE A 346
PRO A 347
GLY A 345
None
1.12A13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEO_B_CYZB1302_1
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA)		2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens)		5 / 9PRO A 551
ASP A 458
PRO A 687
SER A 527
GLY A 518
None
1.21A21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEO_B_CYZB1302_1
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA)		4lot COMPLEMENT C1S
SUBCOMPONENT HEAVY
CHAIN
(Homo
sapiens)		5 / 9PRO A 358
SER A 365
ILE A 346
PRO A 347
GLY A 345
None
1.11A13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEO_C_CYZC1302_1
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA)		2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens)		5 / 9PRO A 687
SER A 527
GLY A 518
PRO A 551
ASP A 458
None
1.19A21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEO_D_CYZD1302_1
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA)		2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens)		5 / 9PRO A 687
SER A 527
GLY A 518
PRO A 551
ASP A 458
None
1.22A21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEO_D_CYZD1302_1
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA)		4lot COMPLEMENT C1S
SUBCOMPONENT HEAVY
CHAIN
(Homo
sapiens)		5 / 9ILE A 346
PRO A 347
GLY A 345
PRO A 358
SER A 365
None
1.12A13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		2g1s RENIN
(Homo
sapiens)		5 / 10LEU A 148
ASP A 177
ILE A  97
SER A   4
GLY A  95
None
1.30A13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		2q9v MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		5 / 10MET A 838
SER A 837
LEU A 882
ILE A 867
GLY A 885
None
1.26A17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		2qs9 RETINOBLASTOMA-BINDI
NG PROTEIN 9
(Homo
sapiens)		5 / 10LEU A 174
ASP A 138
ILE A  72
SER A  75
GLY A  73
None
1.25A13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		2xub DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Homo
sapiens)		5 / 10PRO A 298
LEU A 308
ASP A 260
ILE A 293
SER A 264
None
1.42A11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		3jwe MGLL PROTEIN
(Homo
sapiens)		5 / 10LEU A 260
ASP A 249
ILE A 139
SER A 132
GLY A 135
None
None
None
F4P  A 314 (-1.2A)
None
1.44A15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		3v4p INTEGRIN ALPHA-4
(Homo
sapiens)		5 / 10LEU A  10
SER A 424
ILE A 390
SER A 395
GLY A 387
None
1.44A9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens)		5 / 10SER A 147
SER A  39
LYS A  30
ILE A  45
GLY A  46
None
LLP  A  41 ( 2.9A)
None
LLP  A  41 ( 3.7A)
None
1.01A13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		4m47 DNA POLYMERASE BETA
(Homo
sapiens)		5 / 10LEU A 100
SER A  96
ASP A  91
ILE A 119
GLY A 118
None
1.36A11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		5d39 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 6
(Homo
sapiens)		5 / 10SER A 531
LEU A 615
ILE A 606
SER A 627
GLY A 603
None
1.34A11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		5xau LAMININ SUBUNIT
ALPHA-5
(Homo
sapiens)		5 / 10SER A3024
LEU A3103
SER A2944
ILE A3094
GLY A3093
None
1.22A8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		2cso PLECKSTRIN
(Homo
sapiens)		5 / 10SER A  62
LEU A  82
LEU A  18
ASP A  17
ILE A  32
None
1.37A18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		3hve GIGAXONIN
(Homo
sapiens)		5 / 10LEU A  48
SER A  52
LEU A 114
LYS A 118
ILE A  73
None
1.44A12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		3nzu PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT GAMMA
ISOFORM
(Homo
sapiens)		5 / 10LEU A 838
ASP A 837
ILE A 739
PRO A 786
SER A 701
None
1.37A7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		3ol2 SEMAPHORIN-4D
(Homo
sapiens)		5 / 10LEU A 413
LEU A 312
ASP A 295
ILE A 460
SER A 442
None
1.36A8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1
(Homo
sapiens)		5 / 10SER A  43
LEU A   9
SER A 108
ILE A  29
SER A  95
None
1.34A8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens)		5 / 10LEU A 133
LEU A 148
ASP A 149
LYS A 152
ILE A 260
None
1.46A10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		2g1s RENIN
(Homo
sapiens)		5 / 10ILE A  97
SER A   4
GLY A  95
LEU A 148
ASP A 177
None
1.31A13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		2q9v MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		5 / 10ILE A 867
GLY A 885
MET A 838
SER A 837
LEU A 882
None
1.27A17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		2qs9 RETINOBLASTOMA-BINDI
NG PROTEIN 9
(Homo
sapiens)		5 / 10ILE A  72
SER A  75
GLY A  73
LEU A 174
ASP A 138
None
1.26A13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		2xub DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Homo
sapiens)		5 / 10ILE A 293
SER A 264
PRO A 298
LEU A 308
ASP A 260
None
1.42A11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		3jwe MGLL PROTEIN
(Homo
sapiens)		5 / 10ILE A 139
SER A 132
GLY A 135
LEU A 260
ASP A 249
None
F4P  A 314 (-1.2A)
None
None
None
1.43A15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		3v4p INTEGRIN ALPHA-4
(Homo
sapiens)		5 / 10ILE A 390
SER A 395
GLY A 387
LEU A  10
SER A 424
None
1.44A9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens)		5 / 10ILE A  45
GLY A  46
SER A 147
SER A  39
LYS A  30
LLP  A  41 ( 3.7A)
None
None
LLP  A  41 ( 2.9A)
None
1.01A13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		4m47 DNA POLYMERASE BETA
(Homo
sapiens)		5 / 10ILE A 119
GLY A 118
LEU A 100
SER A  96
ASP A  91
None
1.36A11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		5d39 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 6
(Homo
sapiens)		5 / 10ILE A 606
SER A 627
GLY A 603
SER A 531
LEU A 615
None
1.34A11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		5xau LAMININ SUBUNIT
ALPHA-5
(Homo
sapiens)		5 / 10ILE A3094
GLY A3093
SER A3024
LEU A3103
SER A2944
None
1.23A8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		2cso PLECKSTRIN
(Homo
sapiens)		5 / 11ILE A  32
SER A  62
LEU A  82
LEU A  18
ASP A  17
None
1.37A18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		2iuw ALKYLATED REPAIR
PROTEIN ALKB HOMOLOG
3
(Homo
sapiens)		5 / 11ILE A 237
PRO A  94
LEU A 239
SER A 206
LEU A 207
None
None
None
AKG  A 700 ( 4.1A)
None
1.42A15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM
(Homo
sapiens)		5 / 11ILE A 563
SER A 558
PRO A 523
LEU A 544
LEU A 551
None
1.32A10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens)		5 / 11PRO A 517
MET A 519
LEU A 768
LEU A 776
LYS A 780
None
0.85A14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		3c5w PP2A A SUBUNIT
(Homo
sapiens)		5 / 11ILE A 563
SER A 558
PRO A 523
LEU A 544
LEU A 551
None
1.37A17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		3hve GIGAXONIN
(Homo
sapiens)		5 / 11ILE A  73
LEU A  48
SER A  52
LEU A 114
LYS A 118
None
1.44A12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens)		5 / 11ILE A 460
PRO A 237
MET A 235
LEU A  74
LEU A  80
None
1.32A8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		3nzu PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT GAMMA
ISOFORM
(Homo
sapiens)		5 / 11ILE A 739
PRO A 786
SER A 701
LEU A 838
ASP A 837
None
1.36A7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		3ol2 SEMAPHORIN-4D
(Homo
sapiens)		5 / 11ILE A 460
SER A 442
LEU A 413
LEU A 312
ASP A 295
None
1.36A8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		3qxm GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2
(Homo
sapiens)		5 / 11PRO A 501
MET A 503
LEU A 752
LEU A 760
LYS A 764
None
0.84A16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		3u1k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL
(Homo
sapiens)		5 / 11ILE A 462
PRO A 463
SER A 504
PRO A 501
LEU A 495
None
1.36A9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		4f0x MALONYL-COA
DECARBOXYLASE,
MITOCHONDRIAL
(Homo
sapiens)		5 / 11ILE A 331
PRO A 332
PRO A 418
LEU A 406
LEU A 424
None
1.38A10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		5fo9 COMPLEMENT RECEPTOR
TYPE 1
(Homo
sapiens)		5 / 11ILE C1072
PRO C1070
SER C1112
PRO C1128
SER C1126
None
1.30A19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1
(Homo
sapiens)		5 / 11ILE A  29
SER A  95
SER A  43
LEU A   9
SER A 108
None
1.34A8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		2xub DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Homo
sapiens)		5 / 9PRO A 298
LEU A 308
ASP A 260
ILE A 293
SER A 264
None
1.41A11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		2cbz MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens)		5 / 10MET A 829
SER A 828
LEU A 673
ILE A 811
PRO A 794
None
1.26A18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		2g1s RENIN
(Homo
sapiens)		5 / 10LEU A 148
ASP A 177
ILE A  97
SER A   4
GLY A  95
None
1.30A13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		2q9v MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		5 / 10MET A 838
SER A 837
LEU A 882
ILE A 867
GLY A 885
None
1.28A17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens)		5 / 10SER B 561
LEU B 636
LEU B 819
ILE B 632
GLY B 615
None
1.16A6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		4g8k 2-5A-DEPENDENT
RIBONUCLEASE
(Homo
sapiens)		5 / 10LEU A 279
LEU A 304
ASP A 303
LYS A 326
GLY A 273
None
1.08A11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		5d39 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 6
(Homo
sapiens)		5 / 10SER A 531
LEU A 615
ILE A 606
SER A 627
GLY A 603
None
1.26A11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		5gs0 TOLL-LIKE RECEPTOR 3
(Homo
sapiens)		5 / 10LEU A 271
LEU A 281
ILE A 250
SER A 254
GLY A 225
None
1.26A9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		2xub DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Homo
sapiens)		5 / 9ILE A 293
SER A 264
PRO A 298
LEU A 308
ASP A 260
None
1.42A11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		4g8k 2-5A-DEPENDENT
RIBONUCLEASE
(Homo
sapiens)		5 / 9GLY A 273
LEU A 279
LEU A 304
ASP A 303
LYS A 326
None
1.09A11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		2g1s RENIN
(Homo
sapiens)		5 / 10LEU A 148
ASP A 177
ILE A  97
SER A   4
GLY A  95
None
1.31A13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		2q9v MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		5 / 10MET A 838
SER A 837
LEU A 882
ILE A 867
GLY A 885
None
1.26A17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		2qs9 RETINOBLASTOMA-BINDI
NG PROTEIN 9
(Homo
sapiens)		5 / 10LEU A 174
ASP A 138
ILE A  72
SER A  75
GLY A  73
None
1.26A13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		2xub DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Homo
sapiens)		5 / 10PRO A 298
LEU A 308
ASP A 260
ILE A 293
SER A 264
None
1.43A11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		3jwe MGLL PROTEIN
(Homo
sapiens)		5 / 10LEU A 260
ASP A 249
ILE A 139
SER A 132
GLY A 135
None
None
None
F4P  A 314 (-1.2A)
None
1.44A15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		3v4p INTEGRIN ALPHA-4
(Homo
sapiens)		5 / 10LEU A  10
SER A 424
ILE A 390
SER A 395
GLY A 387
None
1.44A9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens)		5 / 10SER A 147
SER A  39
LYS A  30
ILE A  45
GLY A  46
None
LLP  A  41 ( 2.9A)
None
LLP  A  41 ( 3.7A)
None
1.00A13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		4m47 DNA POLYMERASE BETA
(Homo
sapiens)		5 / 10LEU A 100
SER A  96
ASP A  91
ILE A 119
GLY A 118
None
1.36A11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		5d39 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 6
(Homo
sapiens)		5 / 10SER A 531
LEU A 615
ILE A 606
SER A 627
GLY A 603
None
1.35A11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		5xau LAMININ SUBUNIT
ALPHA-5
(Homo
sapiens)		5 / 10SER A3024
LEU A3103
SER A2944
ILE A3094
GLY A3093
None
1.23A8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		2cso PLECKSTRIN
(Homo
sapiens)		5 / 10SER A  62
LEU A  82
LEU A  18
ASP A  17
ILE A  32
None
1.37A18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		3hve GIGAXONIN
(Homo
sapiens)		5 / 10LEU A  48
SER A  52
LEU A 114
LYS A 118
ILE A  73
None
1.43A12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		3nzu PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT GAMMA
ISOFORM
(Homo
sapiens)		5 / 10LEU A 838
ASP A 837
ILE A 739
PRO A 786
SER A 701
None
1.38A7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		3ol2 SEMAPHORIN-4D
(Homo
sapiens)		5 / 10LEU A 413
LEU A 312
ASP A 295
ILE A 460
SER A 442
None
1.36A8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1
(Homo
sapiens)		5 / 10SER A  43
LEU A   9
SER A 108
ILE A  29
SER A  95
None
1.34A8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens)		5 / 10LEU A 133
LEU A 148
ASP A 149
LYS A 152
ILE A 260
None
1.46A10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		2g1s RENIN
(Homo
sapiens)		5 / 10ILE A  97
SER A   4
GLY A  95
LEU A 148
ASP A 177
None
1.32A13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		2q9v MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		5 / 10ILE A 867
GLY A 885
MET A 838
SER A 837
LEU A 882
None
1.26A17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		2qs9 RETINOBLASTOMA-BINDI
NG PROTEIN 9
(Homo
sapiens)		5 / 10ILE A  72
SER A  75
GLY A  73
LEU A 174
ASP A 138
None
1.27A13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		2xub DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Homo
sapiens)		5 / 10ILE A 293
SER A 264
PRO A 298
LEU A 308
ASP A 260
None
1.43A11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		3jwe MGLL PROTEIN
(Homo
sapiens)		5 / 10ILE A 139
SER A 132
GLY A 135
LEU A 260
ASP A 249
None
F4P  A 314 (-1.2A)
None
None
None
1.44A15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		3v4p INTEGRIN ALPHA-4
(Homo
sapiens)		5 / 10ILE A 390
SER A 395
GLY A 387
LEU A  10
SER A 424
None
1.44A9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens)		5 / 10ILE A  45
GLY A  46
SER A 147
SER A  39
LYS A  30
LLP  A  41 ( 3.7A)
None
None
LLP  A  41 ( 2.9A)
None
1.01A13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		4m47 DNA POLYMERASE BETA
(Homo
sapiens)		5 / 10ILE A 119
GLY A 118
LEU A 100
SER A  96
ASP A  91
None
1.36A11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		5d39 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 6
(Homo
sapiens)		5 / 10ILE A 606
SER A 627
GLY A 603
SER A 531
LEU A 615
None
1.34A11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		5xau LAMININ SUBUNIT
ALPHA-5
(Homo
sapiens)		5 / 10ILE A3094
GLY A3093
SER A3024
LEU A3103
SER A2944
None
1.23A8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		2cso PLECKSTRIN
(Homo
sapiens)		5 / 11ILE A  32
SER A  62
LEU A  82
LEU A  18
ASP A  17
None
1.36A18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		2iuw ALKYLATED REPAIR
PROTEIN ALKB HOMOLOG
3
(Homo
sapiens)		5 / 11ILE A 237
PRO A  94
LEU A 239
SER A 206
LEU A 207
None
None
None
AKG  A 700 ( 4.1A)
None
1.42A15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM
(Homo
sapiens)		5 / 11ILE A 563
SER A 558
PRO A 523
LEU A 544
LEU A 551
None
1.33A10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens)		5 / 11PRO A 517
MET A 519
LEU A 768
LEU A 776
LYS A 780
None
0.84A14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		3c5w PP2A A SUBUNIT
(Homo
sapiens)		5 / 11ILE A 563
SER A 558
PRO A 523
LEU A 544
LEU A 551
None
1.37A17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		3hve GIGAXONIN
(Homo
sapiens)		5 / 11ILE A  73
LEU A  48
SER A  52
LEU A 114
LYS A 118
None
1.44A12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens)		5 / 11ILE A 460
PRO A 237
MET A 235
LEU A  74
LEU A  80
None
1.32A8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		3nzu PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT GAMMA
ISOFORM
(Homo
sapiens)		5 / 11ILE A 739
PRO A 786
SER A 701
LEU A 838
ASP A 837
None
1.36A7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		3ol2 SEMAPHORIN-4D
(Homo
sapiens)		5 / 11ILE A 460
SER A 442
LEU A 413
LEU A 312
ASP A 295
None
1.35A8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		3qxm GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2
(Homo
sapiens)		5 / 11PRO A 501
MET A 503
LEU A 752
LEU A 760
LYS A 764
None
0.84A16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		3u1k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL
(Homo
sapiens)		5 / 11ILE A 462
PRO A 463
SER A 504
PRO A 501
LEU A 495
None
1.37A9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		4f0x MALONYL-COA
DECARBOXYLASE,
MITOCHONDRIAL
(Homo
sapiens)		5 / 11ILE A 331
PRO A 332
PRO A 418
LEU A 406
LEU A 424
None
1.38A10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		5fo9 COMPLEMENT RECEPTOR
TYPE 1
(Homo
sapiens)		5 / 11ILE C1072
PRO C1070
SER C1112
PRO C1128
SER C1126
None
1.30A19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1
(Homo
sapiens)		5 / 11ILE A  29
SER A  95
SER A  43
LEU A   9
SER A 108
None
1.33A8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		1x5x FIBRONECTIN TYPE-III
DOMAIN CONTAINING
PROTEIN 3A
(Homo
sapiens)		5 / 9MET A  10
SER A   9
LEU A  64
SER A  29
SER A  32
None
1.44A17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		2iag PROSTACYCLIN
SYNTHASE
(Homo
sapiens)		5 / 9PRO A 290
MET A 486
LEU A 295
SER A 348
ILE A 451
None
1.22A11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		2xub DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Homo
sapiens)		5 / 9PRO A 298
LEU A 308
ASP A 260
ILE A 293
SER A 264
None
1.39A11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		2cso PLECKSTRIN
(Homo
sapiens)		5 / 10SER A  62
LEU A  82
LEU A  18
ASP A  17
ILE A  32
None
1.38A18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		3hve GIGAXONIN
(Homo
sapiens)		5 / 10LEU A  48
SER A  52
LEU A 114
LYS A 118
ILE A  73
None
1.44A12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		3nzu PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT GAMMA
ISOFORM
(Homo
sapiens)		5 / 10LEU A 838
ASP A 837
ILE A 739
PRO A 786
SER A 701
None
1.37A7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		3ol2 SEMAPHORIN-4D
(Homo
sapiens)		5 / 10LEU A 413
LEU A 312
ASP A 295
ILE A 460
SER A 442
None
1.33A8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		4jqf CST COMPLEX SUBUNIT
STN1
(Homo
sapiens)		5 / 10SER A 334
LEU A 351
LEU A 300
ASP A 299
ILE A 308
None
1.49A21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens)		5 / 10SER A 380
LEU A 104
LYS A 102
ILE A 229
PRO A 371
None
ATP  A 501 ( 4.3A)
None
None
None
1.37A11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens)		5 / 10LEU A 133
LEU A 148
ASP A 149
LYS A 152
ILE A 260
None
1.44A10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		1x5x FIBRONECTIN TYPE-III
DOMAIN CONTAINING
PROTEIN 3A
(Homo
sapiens)		5 / 9SER A  32
MET A  10
SER A   9
LEU A  64
SER A  29
None
1.43A17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		2iag PROSTACYCLIN
SYNTHASE
(Homo
sapiens)		5 / 9ILE A 451
PRO A 290
MET A 486
LEU A 295
SER A 348
None
1.21A11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		2xub DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Homo
sapiens)		5 / 9ILE A 293
SER A 264
PRO A 298
LEU A 308
ASP A 260
None
1.39A11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		2cso PLECKSTRIN
(Homo
sapiens)		5 / 10ILE A  32
SER A  62
LEU A  82
LEU A  18
ASP A  17
None
1.39A18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		3hve GIGAXONIN
(Homo
sapiens)		5 / 10ILE A  73
LEU A  48
SER A  52
LEU A 114
LYS A 118
None
1.44A12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		3nzu PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT GAMMA
ISOFORM
(Homo
sapiens)		5 / 10ILE A 739
PRO A 786
SER A 701
LEU A 838
ASP A 837
None
1.37A7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		3ol2 SEMAPHORIN-4D
(Homo
sapiens)		5 / 10ILE A 460
SER A 442
LEU A 413
LEU A 312
ASP A 295
None
1.33A8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		4jqf CST COMPLEX SUBUNIT
STN1
(Homo
sapiens)		5 / 10ILE A 308
SER A 334
LEU A 351
LEU A 300
ASP A 299
None
1.49A21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens)		5 / 10ILE A 260
LEU A 133
LEU A 148
ASP A 149
LYS A 152
None
1.45A10.31