POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens)		5 / 11LEU A 267
ARG A 274
ILE A 215
LEU A 173
ASP A 171
None
1.19A19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		1htj KIAA0380
(Homo
sapiens)		5 / 11LEU F 324
LEU F 317
ARG F 320
PHE F 311
LEU F 436
None
1.02A17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		1u6g TIP120 PROTEIN
(Homo
sapiens)		5 / 11LEU C 896
LEU C 892
VAL C 885
ILE C 932
LEU C 958
None
1.25A19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens)		5 / 11LEU A 268
LEU A 272
ILE A 313
PHE A 299
LEU A 297
None
1.27A21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM
(Homo
sapiens)		5 / 11LEU A 425
ARG A 427
ILE A 414
LEU A 474
ASP A 470
None
1.23A20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		3jui TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON
(Homo
sapiens)		5 / 11LEU A 646
LEU A 676
ILE A 649
PHE A 670
LEU A 601
None
1.28A14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		3p11 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3
(Homo
sapiens)		5 / 11LEU A  30
VAL A  40
ILE A  46
PHE A  57
LEU A  78
None
1.06A21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens)		5 / 11LEU A1299
VAL A1306
GLN A1308
ILE A1588
LEU A1151
None
None
None
None
SAH  A1601 (-3.6A)
1.13A18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		4eku PROTEIN-TYROSINE
KINASE 2-BETA
(Homo
sapiens)		5 / 11LEU A 176
ILE A 231
PHE A 227
LEU A 210
ASP A 211
None
1.22A22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL
(Homo
sapiens)		5 / 11VAL A  54
ILE A 157
PHE A 260
LEU A 232
ASP A 236
None
1.24A19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		4njz HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL
(Homo
sapiens)		5 / 11LEU A  60
ILE A  92
PHE A  56
LEU A  90
ASP A  80
None
None
None
None
SO4  A 201 (-2.8A)
1.22A15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		4pju COHESIN SUBUNIT SA-2
(Homo
sapiens)		5 / 11LEU A 588
LEU A 574
ILE A 522
ASP A 515
ASP A 581
None
1.27A19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		4qgk FATTY ALDEHYDE
DEHYDROGENASE
(Homo
sapiens)		5 / 11LEU A  27
LEU A  30
VAL A  34
GLN A  35
ASP A  69
None
1.12A23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens)		5 / 11LEU A 114
ARG A 117
GLN A 116
ILE A  60
ASP A  69
None
1.10A23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		4yc7 FORMIN-LIKE PROTEIN
2
(Homo
sapiens)		5 / 11LEU B 265
LEU B 269
VAL B 273
ILE B 225
LEU B 140
None
1.28A21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		4ydh FORMIN-LIKE PROTEIN
1
(Homo
sapiens)		5 / 11LEU A 271
LEU A 275
VAL A 279
ILE A 231
LEU A 154
None
1.26A22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		5k8r PROTOCADHERIN
GAMMA-B3
(Homo
sapiens)		5 / 11LEU A 232
LEU A 271
ILE A 305
PHE A 262
LEU A 277
None
1.14A20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens)		5 / 11LEU A 284
LEU A 288
ILE A 329
PHE A 315
LEU A 313
None
1.21A20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		5w21 KLOTHO
(Homo
sapiens)		5 / 11LEU A 398
VAL A 413
ILE A 401
PHE A 367
LEU A 324
None
1.25A11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15
(Homo
sapiens)		5 / 11LEU A 259
LEU A 272
ILE A 257
PHE A 304
LEU A 286
None
1.18A20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		1bf5 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens)		4 / 7ILE A 578
ARG A 602
PHE A 581
PHE A 506
None
1.09A22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		1ne7 GLUCOSAMINE-6-PHOSPH
ATE ISOMERASE
(Homo
sapiens)		4 / 7ILE A  20
PHE A  63
ILE A  99
PHE A  93
None
1.06A20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		1o5t TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens)		4 / 7ILE A 359
PHE A 340
ILE A 175
PHE A 406
None
1.13A21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens)		4 / 7ILE A 359
PHE A 340
ILE A 175
PHE A 406
None
None
TYM  A 501 ( 4.5A)
None
1.02A22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		1rw2 ATP-DEPENDENT DNA
HELICASE II, 80 KDA
SUBUNIT
(Homo
sapiens)		4 / 7ILE A  81
ARG A  96
PHE A  97
ILE A 128
None
1.03A14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		1xkt FATTY ACID SYNTHASE
(Homo
sapiens)		4 / 7ARG A2220
PHE A2375
ILE A2404
PHE A2371
None
1.15A21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		2fej CELLULAR TUMOR
ANTIGEN P53
(Homo
sapiens)		4 / 7ILE A 251
ARG A 158
ILE A 255
PHE A 270
None
1.06A16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		2g2b ALLOGRAFT
INFLAMMATORY FACTOR
1
(Homo
sapiens)		4 / 7ILE A  68
ARG A  26
ILE A  30
PHE A  53
None
0.99A14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		2i7n PANTOTHENATE KINASE
1
(Homo
sapiens)		4 / 7ARG A 311
PHE A 312
ILE A 310
PHE A 320
None
1.09A19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		2i7n PANTOTHENATE KINASE
1
(Homo
sapiens)		4 / 7ILE A 243
PHE A 312
ILE A 310
PHE A 320
None
1.07A19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		2m76 CARNITINE
O-PALMITOYLTRANSFERA
SE 1, BRAIN ISOFORM
(Homo
sapiens)		4 / 7ILE A  31
SER A  34
ARG A  37
ARG A  41
None
1.05A8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		2ock VALACYCLOVIR
HYDROLASE
(Homo
sapiens)		4 / 7ARG A 197
PHE A 199
ILE A 196
PHE A  97
None
1.07A19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		2v5o CATION-INDEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR
(Homo
sapiens)		4 / 7ILE A1918
ARG A1615
ARG A1669
PHE A1905
None
0.91A22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		2x25 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
A
(Homo
sapiens)		4 / 7SER B  40
PHE B 112
ILE B 114
PHE B  53
None
1.14A15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		2xsw 72 KDA INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE
(Homo
sapiens)		4 / 7ILE A 421
SER A 423
ARG A 435
ILE A 519
None
0.80A21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		4ky9 BAND 3 ANION
TRANSPORT PROTEIN
(Homo
sapiens)		4 / 7SER A 310
ARG A 111
PHE A 114
PHE A 266
None
1.13A19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens)		4 / 7ILE A 254
ARG A  77
ILE A  75
PHE A 114
None
1.04A20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		5bv8 VON WILLEBRAND
FACTOR
(Homo
sapiens)		4 / 7ILE A1309
ARG A1374
ARG A1379
PHE A1280
None
1.12A17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		5kbd TUMOR PROTEIN P73
(Homo
sapiens)		4 / 7ILE A 271
ARG A 176
ILE A 275
PHE A 290
None
1.16A15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		5oom 39S RIBOSOMAL
PROTEIN L43,
MITOCHONDRIAL
(Homo
sapiens)		4 / 7ILE b  63
ARG b  74
ILE b  89
PHE b  46
None
C  A2284 ( 3.3A)
None
None
0.85A16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		5ufl PROTEIN CIP2A
(Homo
sapiens)		4 / 7ILE A 393
PHE A 370
ILE A 369
PHE A 385
None
0.93A21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		5y30 LEUCINE-RICH
GLIOMA-INACTIVATED
PROTEIN 1
(Homo
sapiens)		4 / 7ILE A  61
PHE A  98
ILE A 122
PHE A 111
None
0.97A9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		5y31 LEUCINE-RICH
GLIOMA-INACTIVATED
PROTEIN 1
(Homo
sapiens)		4 / 7ILE B  61
PHE B  98
ILE B 122
PHE B 111
None
0.95A9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens)		5 / 11LEU A 267
ARG A 274
ILE A 215
LEU A 173
ASP A 171
None
1.19A19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		1htj KIAA0380
(Homo
sapiens)		5 / 11LEU F 324
LEU F 317
ARG F 320
PHE F 311
LEU F 436
None
1.00A17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		2can ORNITHINE
AMINOTRANSFERASE
(Homo
sapiens)		5 / 11LEU A 360
LEU A 363
VAL A 367
ILE A 432
LEU A 397
None
1.19A22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens)		5 / 11LEU A 268
LEU A 272
ILE A 313
PHE A 299
LEU A 297
None
1.22A21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM
(Homo
sapiens)		5 / 11LEU A 425
ARG A 427
ILE A 414
LEU A 474
ASP A 470
None
1.26A20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens)		5 / 11LEU A1299
VAL A1306
GLN A1308
ILE A1588
LEU A1151
None
None
None
None
SAH  A1601 (-3.6A)
1.11A18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		4eku PROTEIN-TYROSINE
KINASE 2-BETA
(Homo
sapiens)		5 / 11LEU A 176
ILE A 231
PHE A 227
LEU A 210
ASP A 211
None
1.19A22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL
(Homo
sapiens)		5 / 11VAL A  54
ILE A 157
PHE A 260
LEU A 232
ASP A 236
None
1.22A19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		4pju COHESIN SUBUNIT SA-2
(Homo
sapiens)		5 / 11LEU A 588
LEU A 574
ILE A 522
ASP A 515
ASP A 581
None
1.27A19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		4qgk FATTY ALDEHYDE
DEHYDROGENASE
(Homo
sapiens)		5 / 11LEU A  27
LEU A  30
VAL A  34
GLN A  35
ASP A  69
None
1.15A23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		5k8r PROTOCADHERIN
GAMMA-B3
(Homo
sapiens)		5 / 11LEU A 232
LEU A 271
ILE A 305
PHE A 262
LEU A 277
None
1.12A20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens)		5 / 11LEU A 284
LEU A 288
ILE A 329
PHE A 315
LEU A 313
None
1.15A20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		5w21 KLOTHO
(Homo
sapiens)		5 / 11LEU A 398
VAL A 413
ILE A 401
PHE A 367
LEU A 324
None
1.25A11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15
(Homo
sapiens)		5 / 11LEU A 259
LEU A 272
ILE A 257
PHE A 304
LEU A 286
None
1.21A20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA
(Homo
sapiens)		4 / 6SER A 229
ARG A 189
ARG A 192
ILE A 197
None
PTR  A 185 ( 3.6A)
PTR  A 185 ( 3.1A)
None
1.15A21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		1xkt FATTY ACID SYNTHASE
(Homo
sapiens)		4 / 6ARG A2220
PHE A2375
ILE A2404
PHE A2371
None
1.12A21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		1y96 GEM-ASSOCIATED
PROTEIN 7
(Homo
sapiens)		4 / 6ARG B  87
PHE B  80
ILE B 124
PHE B 102
None
1.23A10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		1zv4 REGULATOR OF
G-PROTEIN SIGNALING
17
(Homo
sapiens)		4 / 6SER X 107
ARG X  99
PHE X  98
PHE X  85
None
1.17A13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		2a2n PEPTIDYLPROLYL
ISOMERASE DOMAIN AND
WD REPEAT CONTAINING
1
(Homo
sapiens)		4 / 6SER A 523
PHE A 592
ILE A 594
PHE A 533
None
1.29A14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		2dw4 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1
(Homo
sapiens)		4 / 6SER A 817
ARG A 820
ARG A 824
ILE A 825
None
1.27A23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		2ihd REGULATOR OF
G-PROTEIN SIGNALING
8
(Homo
sapiens)		4 / 6SER A  79
ARG A  71
PHE A  70
PHE A  57
None
1.12A14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		2o2v MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 3
(Homo
sapiens)		4 / 6ARG B  56
PHE B  49
ILE B  58
PHE B  60
None
1.12A8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		2qv2 INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1
(Homo
sapiens)		4 / 6ARG A 274
PHE A 277
ILE A 244
PHE A 331
ARG  A 274 ( 0.6A)
PHE  A 277 ( 1.3A)
ILE  A 244 ( 0.7A)
PHE  A 331 ( 1.3A)
1.28A20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		2v9q ROUNDABOUT HOMOLOG 1
(Homo
sapiens)		4 / 6SER A 117
ARG A 131
PHE A 129
ILE A 132
None
1.19A16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		2x25 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
A
(Homo
sapiens)		4 / 6SER B  40
PHE B 112
ILE B 114
PHE B  53
None
1.13A15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		3hy8 PYRIDOXINE-5'-PHOSPH
ATE OXIDASE
(Homo
sapiens)		4 / 6ARG A 138
PHE A 218
ILE A 230
PHE A 232
None
1.05A17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		3i3n KELCH-LIKE PROTEIN
11
(Homo
sapiens)		4 / 6ARG A 229
PHE A 232
ILE A 228
PHE A 241
None
1.03A19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens)		4 / 6SER A 888
ARG A 779
PHE A 886
ILE A 785
None
1.22A19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		4a0l CULLIN-4B
(Homo
sapiens)		4 / 6ARG E 555
PHE E 551
ILE E 552
PHE E 548
None
1.15A21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		4nnd TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 18
(Homo
sapiens)		4 / 6ARG A 271
PHE A  91
ILE A 102
PHE A 122
None
1.22A19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens)		4 / 6SER A 523
ARG A 664
PHE A 666
PHE A 628
None
1.15A22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		5do9 REGULATOR OF
G-PROTEIN SIGNALING
8
(Homo
sapiens)		4 / 6SER B  79
ARG B  71
PHE B  70
PHE B  57
None
1.22A12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		5ek0 CHIMERA OF BACTERIAL
ION TRANSPORT
PROTEIN AND HUMAN
SODIUM CHANNEL
PROTEIN TYPE 9
SUBUNIT ALPHA
(Arcobacter
butzleri;
Homo
sapiens)		4 / 6ARG A1559
PHE A1562
ILE A1555
PHE A1572
None
1.20A23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		5k1b WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens)		4 / 6SER B 533
ARG B 527
PHE B 517
ILE B 516
None
1.20A20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2
(Homo
sapiens)		4 / 6ARG A 715
PHE A 654
ILE A 717
PHE A 670
None
0.98A20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		5l3d LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1A
(Homo
sapiens)		4 / 6SER A 817
ARG A 820
ARG A 824
ILE A 825
None
1.27A20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		5mgv PHENYLALANINE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens)		4 / 6ARG A 414
PHE A 333
ILE A 331
PHE A 345
None
1.27A21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		5y30 LEUCINE-RICH
GLIOMA-INACTIVATED
PROTEIN 1
(Homo
sapiens)		4 / 6SER A  77
PHE A  98
ILE A 122
PHE A 111
None
1.22A9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens)		4 / 6ARG C  82
ARG C  79
PHE C  78
ILE C  76
None
1.10A8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		1y0l CATALYTIC ANTIBODY
FAB 34E4 HEAVY CHAIN
(Homo
sapiens;
Mus
musculus)		5 / 11PRO H  14
VAL H 111
ALA H  12
SER H  82
GLY H  16
None
1.30A18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL
(Homo
sapiens)		5 / 11VAL A 130
ALA A 129
SER A 124
SER A 125
GLY A 384
None
1.32A23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		2yun NOSTRIN
(Homo
sapiens)		5 / 11PRO A  55
VAL A  59
ALA A  57
PHE A  54
GLY A  41
None
1.31A10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens)		5 / 11VAL A 316
ALA A 315
SER A 313
GLY A 370
THR A 366
None
1.31A23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		4xvm DNA POLYMERASE NU
(Homo
sapiens)		5 / 11ASP A 623
VAL A 821
ALA A 818
PHE A 807
SER A 847
None
1.21A22.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MMA_A_CXXA603_1
(TRANSPORTER)		5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER
(Homo
sapiens)		6 / 11TYR A  95
ALA A 173
TYR A 176
SER A 438
GLY A 442
THR A 497
None
0.72A32.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MMA_A_CXXA603_1
(TRANSPORTER)		5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER
(Homo
sapiens)		6 / 11TYR A  95
ASP A  98
ALA A 173
TYR A 176
GLY A 442
THR A 497
None
0.97A32.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MMA_A_CXXA603_1
(TRANSPORTER)		5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER
(Homo
sapiens)		5 / 11TYR A  95
ASP A  98
TYR A 176
SER A 439
GLY A 442
None
0.93A32.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MMA_A_CXXA603_1
(TRANSPORTER)		5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER
(Homo
sapiens)		5 / 11TYR A  95
TYR A 176
SER A 438
SER A 439
GLY A 442
None
0.83A32.24