POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.


DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)
2esp UBIQUITIN-CONJUGATIN
G ENZYME E2 D2
(Homo
sapiens)
5 / 12PRO A  65
THR A  53
VAL A  67
LEU A  86
ILE A 106
None
1.47A21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)
2xdv MYC-INDUCED NUCLEAR
ANTIGEN
(Homo
sapiens)
5 / 12SER A 257
PRO A 140
THR A 255
VAL A 254
ILE A 150
None
None
OGA  A 601 (-3.0A)
None
None
1.42A18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)
3gov MASP-1
(Homo
sapiens)
5 / 12PRO A 360
THR A 344
VAL A 327
LEU A 304
SER A 356
None
GOL  A   1 (-4.6A)
None
None
None
1.46A19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)
3kij PROBABLE GLUTATHIONE
PEROXIDASE 8
(Homo
sapiens)
5 / 12SER A  99
PHE A 101
PRO A 135
LEU A  62
SER A  70
None
1.00A19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)
4aqb MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens)
5 / 12PRO A 360
THR A 344
VAL A 327
LEU A 304
SER A 356
None
1.46A18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)
4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL
(Homo
sapiens)
5 / 12PHE A 277
THR A 346
VAL A 347
LEU A 320
ILE A 316
None
1.39A11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)
4fys AMINOPEPTIDASE N
(Homo
sapiens)
5 / 12PHE A 898
THR A 906
VAL A 905
LEU A 845
ILE A 863
None
1.23A12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)
4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens)
5 / 12SER A 230
ARG A 208
LEU A 179
ILE A  76
SER A 213
None
1.32A20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)
4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens)
5 / 12SER B 230
ARG B 208
LEU B 179
ILE B  76
SER B 213
None
1.31A21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)
4xii CHOLINESTERASE
(Homo
sapiens)
5 / 12PHE A 405
PRO A 303
VAL A 233
LEU A 168
SER A 205
None
1.27A17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)
4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens)
5 / 12HIS A 167
SER A 163
HIS A 148
THR A 161
ILE A 178
None
1.45A19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)
5d2n C25 BETA
(Homo
sapiens)
5 / 12SER F 109
PHE F 107
ARG F  36
GLN F   6
LEU F  77
None
1.31A22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)
5h07 POLYUBIQUITIN-C
(Homo
sapiens)
5 / 12SER A 157
THR A 155
LEU A 115
ILE A 103
SER A 165
None
1.45A22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_A_CTCA1385_0
(TETX2 PROTEIN)
1z68 FIBROBLAST
ACTIVATION PROTEIN,
ALPHA SUBUNIT
(Homo
sapiens)
5 / 10ASP A 573
PHE A 350
GLY A 349
PRO A 544
GLY A 542
None
1.44A19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_A_CTCA1385_0
(TETX2 PROTEIN)
2dw4 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1
(Homo
sapiens)
5 / 10GLN A 554
ARG A 820
GLY A 770
PRO A 808
GLY A 813
None
1.26A21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_A_CTCA1385_0
(TETX2 PROTEIN)
5l3d LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1A
(Homo
sapiens)
5 / 10GLN A 554
ARG A 820
GLY A 770
PRO A 808
GLY A 813
None
1.34A19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)
1k4q GLUTATHIONE
REDUCTASE
(Homo
sapiens)
4 / 8ARG A 352
PHE A 354
PRO A 150
GLY A 325
None
0.89A21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)
1u31 NAD(P)
TRANSHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens)
4 / 8ARG A  89
GLY A  92
PRO A  52
GLY A 128
NDP  A 300 (-3.1A)
None
None
NDP  A 300 (-3.6A)
0.95A20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)
2dw4 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1
(Homo
sapiens)
5 / 8GLN A 554
ARG A 820
GLY A 770
PRO A 808
GLY A 813
None
1.27A21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)
3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens)
4 / 8ARG A  65
GLY A 374
PRO A 138
GLY A 140
None
0.92A21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)
3p9h TUMOR SUSCEPTIBILITY
GENE 101 PROTEIN
(Homo
sapiens)
4 / 8GLY A 107
PRO A  71
GLY A  57
MET A 131
None
0.87A15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)
4y85 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 8
(Homo
sapiens)
4 / 8MET A 207
GLY A 210
PRO A 145
GLY A 147
499  A 401 ( 3.7A)
499  A 401 (-3.4A)
499  A 401 (-4.2A)
499  A 401 (-3.3A)
0.77A21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)
5epg ALDEHYDE OXIDASE
(Homo
sapiens)
4 / 8GLN A 927
PHE A 923
GLY A 924
GLY A 809
None
MOS  A3005 (-4.2A)
None
None
0.70A14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)
5l3d LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1A
(Homo
sapiens)
5 / 8GLN A 554
ARG A 820
GLY A 770
PRO A 808
GLY A 813
None
1.36A19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)
5u3p DH511.4 FAB HEAVY
CHAIN
DH511.4 FAB LIGHT
CHAIN
(Homo
sapiens;
Homo
sapiens)
4 / 8PHE L  98
GLY L  99
GLY H  60
MET H 100
None
0.71A19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)
(Homo
sapiens)
4 / 8MET A 196
PHE A 199
GLY A 202
GLY A 225
None
0.95Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_C_CTCC1385_0
(TETX2 PROTEIN)
1z68 FIBROBLAST
ACTIVATION PROTEIN,
ALPHA SUBUNIT
(Homo
sapiens)
5 / 12ASP A 573
PHE A 350
GLY A 349
PRO A 544
GLY A 542
None
1.43A19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_C_CTCC1385_0
(TETX2 PROTEIN)
2dw4 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1
(Homo
sapiens)
5 / 12GLN A 554
ARG A 820
GLY A 770
PRO A 808
GLY A 813
None
1.27A21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_C_CTCC1385_0
(TETX2 PROTEIN)
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR
(Homo
sapiens)
5 / 12ASP A 778
ARG A 782
GLY A 852
SER A 850
MET A 875
None
1.50A20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_C_CTCC1385_0
(TETX2 PROTEIN)
3fby CARTILAGE OLIGOMERIC
MATRIX PROTEIN
(Homo
sapiens)
5 / 12GLN A 604
GLY A 440
SER A 454
PRO A 690
GLY A 693
None
1.33A19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_C_CTCC1385_0
(TETX2 PROTEIN)
4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens)
5 / 12PHE A 464
HIS A 459
GLY A 462
PRO A 505
GLY A 520
None
1.39A21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_C_CTCC1385_0
(TETX2 PROTEIN)
5l3d LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1A
(Homo
sapiens)
5 / 12GLN A 554
ARG A 820
GLY A 770
PRO A 808
GLY A 813
None
1.36A19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_D_CTCD1385_0
(TETX2 PROTEIN)
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR
(Homo
sapiens)
5 / 10ASP A 778
ARG A 782
GLY A 852
SER A 850
MET A 875
None
1.49A20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))
1x27 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK
(Homo
sapiens)
5 / 12GLU A 125
LEU A 220
THR A 210
GLY A 201
ILE A 183
None
1.09A19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))
1z2m INTERFERON,
ALPHA-INDUCIBLE
PROTEIN (CLONE
IFI-15K)
(Homo
sapiens)
5 / 12LEU A  54
GLY A  64
PHE A  15
VAL A  17
ILE A  32
None
1.35A16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))
2g1s RENIN
(Homo
sapiens)
5 / 12VAL A  83
GLY A 124
PHE A  32
VAL A  30
ILE A  19
None
1.07A21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))
2kxr TIGHT JUNCTION
PROTEIN ZO-1
(Homo
sapiens)
5 / 12PHE A  10
GLY A  23
PHE A  77
VAL A  81
ILE A  28
None
1.17A13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))
2vc2 INTEGRIN ALPHA-IIB
(Homo
sapiens)
5 / 12GLY A 438
PRO A  40
GLY A  52
PHE A  70
ILE A 104
None
1.14A22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))
3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C
(Homo
sapiens)
5 / 12GLY A 221
PHE A 260
VAL A 291
LEU A 312
VAL A 254
None
1.22A20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))
3ihw CENTG3
(Homo
sapiens)
5 / 12GLU A 120
THR A 230
GLY A 197
VAL A  94
ILE A 142
None
1.26A21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))
3naf CALCIUM-ACTIVATED
POTASSIUM CHANNEL
SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1
(Homo
sapiens)
5 / 12GLY A1013
LEU A 503
GLY A 912
GLY A 531
ILE A 598
None
0.86A19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))
3v70 GTPASE IMAP FAMILY
MEMBER 1
(Homo
sapiens)
5 / 12GLY A 206
VAL A 178
LEU A 211
GLY A 182
PHE A 188
None
1.05A21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))
4joi CST COMPLEX SUBUNIT
STN1
CST COMPLEX SUBUNIT
TEN1
(Homo
sapiens;
Homo
sapiens)
5 / 12VAL D  93
THR D  25
GLY D  77
GLY A  76
ILE A  31
None
0.90A14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))
4kt1 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4
(Homo
sapiens)
5 / 12LEU A 298
THR A 318
GLY A 317
VAL A 287
ILE A 303
None
1.16A22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))
4pj1 60 KDA HEAT SHOCK
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens)
5 / 12THR A  91
GLY A  88
GLY A 510
VAL A 124
ILE A 444
ADP  A 601 (-4.0A)
ADP  A 601 (-3.5A)
None
None
None
1.15A25.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))
4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri;
Homo
sapiens)
5 / 12LEU A 298
THR A 318
GLY A 317
VAL A 287
ILE A 303
None
1.11A23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_1
(TETRACYCLINE
DESTRUCTASE TET(50))
1jkw CYCLIN H
(Homo
sapiens)
4 / 5ASP A 173
ARG A 177
LEU A 249
MET A 252
None
1.48A20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_1
(TETRACYCLINE
DESTRUCTASE TET(50))
2l7b APOLIPOPROTEIN E
(Homo
sapiens)
4 / 5ASP A 271
ARG A 264
ARG A 260
LEU A  30
None
1.21A21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_1
(TETRACYCLINE
DESTRUCTASE TET(50))
2l7b APOLIPOPROTEIN E
(Homo
sapiens)
4 / 5ASP A 271
ARG A 264
ARG A 260
LEU A  71
None
1.48A21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_1
(TETRACYCLINE
DESTRUCTASE TET(50))
3hzj RAB
GTPASE-ACTIVATING
PROTEIN 1-LIKE
(Homo
sapiens)
4 / 5ASP A 581
ARG A 584
LEU A 652
MET A 647
None
1.23A21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_1
(TETRACYCLINE
DESTRUCTASE TET(50))
4yub NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens)
4 / 5ASP A  62
ARG A  65
LEU A 170
MET A 168
None
1.32A20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_1
(TETRACYCLINE
DESTRUCTASE TET(50))
6fx0 RETINOIC ACID
RECEPTOR GAMMA
(Homo
sapiens)
4 / 5ASP A 269
ARG A 387
LEU A 321
MET A 323
None
1.44Aundetectable