POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		1q7l AMINOACYLASE-1
(Homo
sapiens)		4 / 8GLU A 175
HIS A  80
ASP A 113
GLU A 148
 ZN  A1002 ( 1.9A)
ZN  A1002 ( 3.2A)
ZN  A1002 (-2.5A)
ZN  A1001 (-1.9A)
0.87A19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		2gk1 BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN B
(Homo
sapiens)		4 / 8GLU M 288
HIS N 350
HIS M 235
GLU N 422
None
0.94A24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		2o36 THIMET
OLIGOPEPTIDASE
(Homo
sapiens)		4 / 8GLU A 502
HIS A 473
HIS A 477
GLU A 474
 ZN  A 690 (-2.3A)
ZN  A 690 (-3.4A)
ZN  A 690 (-3.3A)
ZN  A 690 ( 4.1A)
0.88A16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		4 / 8GLU A 411
HIS A 383
HIS A 387
GLU A 384
 ZN  A1628 ( 2.4A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
0.81A19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		4 / 8GLU A 389
HIS A 361
HIS A 365
GLU A 362
 ZN  A1620 ( 2.4A)
3ES  A1611 ( 3.2A)
ZN  A1620 ( 3.2A)
3ES  A1611 (-2.5A)
0.78A17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens)		4 / 8GLU A 667
HIS A 607
HIS A 611
GLU A 608
 ZN  A 771 ( 2.1A)
ZN  A 771 ( 3.4A)
ZN  A 771 ( 3.3A)
RDF  A 817 (-2.4A)
0.75A16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		3fe4 CARBONIC ANHYDRASE 6
(Homo
sapiens)		4 / 8HIS A 138
TYR A 263
HIS A 113
GLU A 136
 MG  A 901 (-3.2A)
None
MG  A 901 (-3.4A)
None
0.85A24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens)		4 / 8GLU A1318
HIS A1295
HIS A1299
GLU A1296
 ZN  A2001 ( 2.2A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
0.89A19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens)		4 / 8GLU A 262
HIS A 223
HIS A 227
GLU A 224
 ZN  A1916 (-2.0A)
ZN  A1916 (-3.3A)
ZN  A1916 (-3.3A)
ZN  A1916 ( 4.3A)
0.88A13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		4fys AMINOPEPTIDASE N
(Homo
sapiens)		4 / 8GLU A 411
HIS A 388
HIS A 392
GLU A 389
None
0.86A13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		4pj6 LEUCYL-CYSTINYL
AMINOPEPTIDASE
(Homo
sapiens)		4 / 8GLU A 487
HIS A 464
HIS A 468
GLU A 465
 ZN  A1101 ( 1.9A)
ZN  A1101 ( 3.2A)
ZN  A1101 (-3.2A)
LYS  A1102 (-3.4A)
0.81A14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		5iry DESMOCOLLIN-1
(Homo
sapiens)		4 / 8GLU A 402
ASP A 400
TYR A 436
HIS A 439
 CA  A 609 ( 2.1A)
CA  A 609 (-3.0A)
None
None
0.91A20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		5syt CAAX PRENYL PROTEASE
1 HOMOLOG
(Homo
sapiens)		5 / 8GLU A 415
HIS A 335
HIS A 459
HIS A 339
GLU A 336
 ZN  A 517 (-2.1A)
ZN  A 517 (-3.2A)
DMS  A 523 (-4.3A)
ZN  A 517 (-3.2A)
ZN  A 517 (-3.9A)
1.26A18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		1q7l AMINOACYLASE-1
(Homo
sapiens)		4 / 8GLU A 175
HIS A  80
ASP A 113
GLU A 148
 ZN  A1002 ( 1.9A)
ZN  A1002 ( 3.2A)
ZN  A1002 (-2.5A)
ZN  A1001 (-1.9A)
0.87A19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		2o36 THIMET
OLIGOPEPTIDASE
(Homo
sapiens)		4 / 8GLU A 502
HIS A 473
HIS A 477
GLU A 474
 ZN  A 690 (-2.3A)
ZN  A 690 (-3.4A)
ZN  A 690 (-3.3A)
ZN  A 690 ( 4.1A)
0.88A16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		4 / 8GLU A 411
HIS A 383
HIS A 387
GLU A 384
 ZN  A1628 ( 2.4A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
0.83A19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		4 / 8GLU A 389
HIS A 361
HIS A 365
GLU A 362
 ZN  A1620 ( 2.4A)
3ES  A1611 ( 3.2A)
ZN  A1620 ( 3.2A)
3ES  A1611 (-2.5A)
0.80A17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens)		4 / 8GLU A 667
HIS A 607
HIS A 611
GLU A 608
 ZN  A 771 ( 2.1A)
ZN  A 771 ( 3.4A)
ZN  A 771 ( 3.3A)
RDF  A 817 (-2.4A)
0.75A16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		3fe4 CARBONIC ANHYDRASE 6
(Homo
sapiens)		4 / 8HIS A 138
TYR A 263
HIS A 113
GLU A 136
 MG  A 901 (-3.2A)
None
MG  A 901 (-3.4A)
None
0.85A24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens)		4 / 8GLU A1318
HIS A1295
HIS A1299
GLU A1296
 ZN  A2001 ( 2.2A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
0.89A19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens)		4 / 8GLU A 262
HIS A 223
HIS A 227
GLU A 224
 ZN  A1916 (-2.0A)
ZN  A1916 (-3.3A)
ZN  A1916 (-3.3A)
ZN  A1916 ( 4.3A)
0.88A13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		4fys AMINOPEPTIDASE N
(Homo
sapiens)		4 / 8GLU A 411
HIS A 388
HIS A 392
GLU A 389
None
0.86A13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		4pj6 LEUCYL-CYSTINYL
AMINOPEPTIDASE
(Homo
sapiens)		4 / 8GLU A 487
HIS A 464
HIS A 468
GLU A 465
 ZN  A1101 ( 1.9A)
ZN  A1101 ( 3.2A)
ZN  A1101 (-3.2A)
LYS  A1102 (-3.4A)
0.81A14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		5iry DESMOCOLLIN-1
(Homo
sapiens)		4 / 8GLU A 402
ASP A 400
TYR A 436
HIS A 439
 CA  A 609 ( 2.1A)
CA  A 609 (-3.0A)
None
None
0.93A20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		5syt CAAX PRENYL PROTEASE
1 HOMOLOG
(Homo
sapiens)		5 / 8GLU A 415
HIS A 335
HIS A 459
HIS A 339
GLU A 336
 ZN  A 517 (-2.1A)
ZN  A 517 (-3.2A)
DMS  A 523 (-4.3A)
ZN  A 517 (-3.2A)
ZN  A 517 (-3.9A)
1.26A18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		1q7l AMINOACYLASE-1
(Homo
sapiens)		4 / 8GLU A 175
HIS A  80
ASP A 113
GLU A 148
 ZN  A1002 ( 1.9A)
ZN  A1002 ( 3.2A)
ZN  A1002 (-2.5A)
ZN  A1001 (-1.9A)
0.88A19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		2o36 THIMET
OLIGOPEPTIDASE
(Homo
sapiens)		4 / 8GLU A 502
HIS A 473
HIS A 477
GLU A 474
 ZN  A 690 (-2.3A)
ZN  A 690 (-3.4A)
ZN  A 690 (-3.3A)
ZN  A 690 ( 4.1A)
0.89A16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		4 / 8GLU A 411
HIS A 383
HIS A 387
GLU A 384
 ZN  A1628 ( 2.4A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
0.83A19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		4 / 8GLU A 389
HIS A 361
HIS A 365
GLU A 362
 ZN  A1620 ( 2.4A)
3ES  A1611 ( 3.2A)
ZN  A1620 ( 3.2A)
3ES  A1611 (-2.5A)
0.79A17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens)		4 / 8GLU A 667
HIS A 607
HIS A 611
GLU A 608
 ZN  A 771 ( 2.1A)
ZN  A 771 ( 3.4A)
ZN  A 771 ( 3.3A)
RDF  A 817 (-2.4A)
0.76A16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		3fe4 CARBONIC ANHYDRASE 6
(Homo
sapiens)		4 / 8HIS A 138
TYR A 263
HIS A 113
GLU A 136
 MG  A 901 (-3.2A)
None
MG  A 901 (-3.4A)
None
0.88A24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens)		4 / 8GLU A1318
HIS A1295
HIS A1299
GLU A1296
 ZN  A2001 ( 2.2A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
0.89A19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens)		4 / 8GLU A 262
HIS A 223
HIS A 227
GLU A 224
 ZN  A1916 (-2.0A)
ZN  A1916 (-3.3A)
ZN  A1916 (-3.3A)
ZN  A1916 ( 4.3A)
0.88A13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		4fys AMINOPEPTIDASE N
(Homo
sapiens)		4 / 8GLU A 411
HIS A 388
HIS A 392
GLU A 389
None
0.87A13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		4pj6 LEUCYL-CYSTINYL
AMINOPEPTIDASE
(Homo
sapiens)		4 / 8GLU A 487
HIS A 464
HIS A 468
GLU A 465
 ZN  A1101 ( 1.9A)
ZN  A1101 ( 3.2A)
ZN  A1101 (-3.2A)
LYS  A1102 (-3.4A)
0.82A14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		5iry DESMOCOLLIN-1
(Homo
sapiens)		4 / 8GLU A 402
ASP A 400
TYR A 436
HIS A 439
 CA  A 609 ( 2.1A)
CA  A 609 (-3.0A)
None
None
0.94A20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		5syt CAAX PRENYL PROTEASE
1 HOMOLOG
(Homo
sapiens)		5 / 8GLU A 415
HIS A 335
HIS A 459
HIS A 339
GLU A 336
 ZN  A 517 (-2.1A)
ZN  A 517 (-3.2A)
DMS  A 523 (-4.3A)
ZN  A 517 (-3.2A)
ZN  A 517 (-3.9A)
1.27A18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		1q7l AMINOACYLASE-1
(Homo
sapiens)		4 / 8GLU A 175
HIS A  80
ASP A 113
GLU A 148
 ZN  A1002 ( 1.9A)
ZN  A1002 ( 3.2A)
ZN  A1002 (-2.5A)
ZN  A1001 (-1.9A)
0.88A19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		2gk1 BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN B
(Homo
sapiens)		4 / 8GLU M 288
HIS N 350
HIS M 235
GLU N 422
None
0.96A24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		2o36 THIMET
OLIGOPEPTIDASE
(Homo
sapiens)		4 / 8GLU A 502
HIS A 473
HIS A 477
GLU A 474
 ZN  A 690 (-2.3A)
ZN  A 690 (-3.4A)
ZN  A 690 (-3.3A)
ZN  A 690 ( 4.1A)
0.91A16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		4 / 8GLU A 411
HIS A 383
HIS A 387
GLU A 384
 ZN  A1628 ( 2.4A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
0.85A19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		4 / 8GLU A 389
HIS A 361
HIS A 365
GLU A 362
 ZN  A1620 ( 2.4A)
3ES  A1611 ( 3.2A)
ZN  A1620 ( 3.2A)
3ES  A1611 (-2.5A)
0.81A17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens)		4 / 8GLU A 667
HIS A 607
HIS A 611
GLU A 608
 ZN  A 771 ( 2.1A)
ZN  A 771 ( 3.4A)
ZN  A 771 ( 3.3A)
RDF  A 817 (-2.4A)
0.78A16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		3fe4 CARBONIC ANHYDRASE 6
(Homo
sapiens)		4 / 8HIS A 138
TYR A 263
HIS A 113
GLU A 136
 MG  A 901 (-3.2A)
None
MG  A 901 (-3.4A)
None
0.83A24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens)		4 / 8GLU A 262
HIS A 223
HIS A 227
GLU A 224
 ZN  A1916 (-2.0A)
ZN  A1916 (-3.3A)
ZN  A1916 (-3.3A)
ZN  A1916 ( 4.3A)
0.90A13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		4fys AMINOPEPTIDASE N
(Homo
sapiens)		4 / 8GLU A 411
HIS A 388
HIS A 392
GLU A 389
None
0.88A13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		4pj6 LEUCYL-CYSTINYL
AMINOPEPTIDASE
(Homo
sapiens)		4 / 8GLU A 487
HIS A 464
HIS A 468
GLU A 465
 ZN  A1101 ( 1.9A)
ZN  A1101 ( 3.2A)
ZN  A1101 (-3.2A)
LYS  A1102 (-3.4A)
0.83A14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		5iry DESMOCOLLIN-1
(Homo
sapiens)		4 / 8GLU A 402
ASP A 400
TYR A 436
HIS A 439
 CA  A 609 ( 2.1A)
CA  A 609 (-3.0A)
None
None
0.91A20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens)		4 / 8GLU A 393
HIS A 370
HIS A 374
GLU A 371
 ZN  A1001 ( 1.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
0.99A14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		5syt CAAX PRENYL PROTEASE
1 HOMOLOG
(Homo
sapiens)		5 / 8GLU A 415
HIS A 335
HIS A 459
HIS A 339
GLU A 336
 ZN  A 517 (-2.1A)
ZN  A 517 (-3.2A)
DMS  A 523 (-4.3A)
ZN  A 517 (-3.2A)
ZN  A 517 (-3.9A)
1.26A18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		1q7l AMINOACYLASE-1
(Homo
sapiens)		4 / 8GLU A 175
HIS A  80
ASP A 113
GLU A 148
 ZN  A1002 ( 1.9A)
ZN  A1002 ( 3.2A)
ZN  A1002 (-2.5A)
ZN  A1001 (-1.9A)
0.87A19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		2gk1 BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN B
(Homo
sapiens)		4 / 8GLU M 288
HIS N 350
HIS M 235
GLU N 422
None
0.97A24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		2o36 THIMET
OLIGOPEPTIDASE
(Homo
sapiens)		4 / 8GLU A 502
HIS A 473
HIS A 477
GLU A 474
 ZN  A 690 (-2.3A)
ZN  A 690 (-3.4A)
ZN  A 690 (-3.3A)
ZN  A 690 ( 4.1A)
0.90A16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		4 / 8GLU A 411
HIS A 383
HIS A 387
GLU A 384
 ZN  A1628 ( 2.4A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
0.85A19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		4 / 8GLU A 389
HIS A 361
HIS A 365
GLU A 362
 ZN  A1620 ( 2.4A)
3ES  A1611 ( 3.2A)
ZN  A1620 ( 3.2A)
3ES  A1611 (-2.5A)
0.81A17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens)		4 / 8GLU A 667
HIS A 607
HIS A 611
GLU A 608
 ZN  A 771 ( 2.1A)
ZN  A 771 ( 3.4A)
ZN  A 771 ( 3.3A)
RDF  A 817 (-2.4A)
0.78A16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		3fe4 CARBONIC ANHYDRASE 6
(Homo
sapiens)		4 / 8HIS A 138
TYR A 263
HIS A 113
GLU A 136
 MG  A 901 (-3.2A)
None
MG  A 901 (-3.4A)
None
0.84A24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens)		4 / 8GLU A 262
HIS A 223
HIS A 227
GLU A 224
 ZN  A1916 (-2.0A)
ZN  A1916 (-3.3A)
ZN  A1916 (-3.3A)
ZN  A1916 ( 4.3A)
0.90A13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		4fys AMINOPEPTIDASE N
(Homo
sapiens)		4 / 8GLU A 411
HIS A 388
HIS A 392
GLU A 389
None
0.88A13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		4pj6 LEUCYL-CYSTINYL
AMINOPEPTIDASE
(Homo
sapiens)		4 / 8GLU A 487
HIS A 464
HIS A 468
GLU A 465
 ZN  A1101 ( 1.9A)
ZN  A1101 ( 3.2A)
ZN  A1101 (-3.2A)
LYS  A1102 (-3.4A)
0.83A14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		5iry DESMOCOLLIN-1
(Homo
sapiens)		4 / 8GLU A 402
ASP A 400
TYR A 436
HIS A 439
 CA  A 609 ( 2.1A)
CA  A 609 (-3.0A)
None
None
0.90A20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens)		4 / 8GLU A 393
HIS A 370
HIS A 374
GLU A 371
 ZN  A1001 ( 1.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
0.99A14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		5syt CAAX PRENYL PROTEASE
1 HOMOLOG
(Homo
sapiens)		5 / 8GLU A 415
HIS A 335
HIS A 459
HIS A 339
GLU A 336
 ZN  A 517 (-2.1A)
ZN  A 517 (-3.2A)
DMS  A 523 (-4.3A)
ZN  A 517 (-3.2A)
ZN  A 517 (-3.9A)
1.26A18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		1q7l AMINOACYLASE-1
(Homo
sapiens)		4 / 8GLU A 175
HIS A  80
ASP A 113
GLU A 148
 ZN  A1002 ( 1.9A)
ZN  A1002 ( 3.2A)
ZN  A1002 (-2.5A)
ZN  A1001 (-1.9A)
0.87A19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		2gk1 BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN B
(Homo
sapiens)		4 / 8GLU M 288
HIS N 350
HIS M 235
GLU N 422
None
0.95A24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		2o36 THIMET
OLIGOPEPTIDASE
(Homo
sapiens)		4 / 8GLU A 502
HIS A 473
HIS A 477
GLU A 474
 ZN  A 690 (-2.3A)
ZN  A 690 (-3.4A)
ZN  A 690 (-3.3A)
ZN  A 690 ( 4.1A)
0.89A16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		4 / 8GLU A 411
HIS A 383
HIS A 387
GLU A 384
 ZN  A1628 ( 2.4A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
0.84A19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		4 / 8GLU A 389
HIS A 361
HIS A 365
GLU A 362
 ZN  A1620 ( 2.4A)
3ES  A1611 ( 3.2A)
ZN  A1620 ( 3.2A)
3ES  A1611 (-2.5A)
0.80A17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens)		4 / 8GLU A 667
HIS A 607
HIS A 611
GLU A 608
 ZN  A 771 ( 2.1A)
ZN  A 771 ( 3.4A)
ZN  A 771 ( 3.3A)
RDF  A 817 (-2.4A)
0.77A16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		3fe4 CARBONIC ANHYDRASE 6
(Homo
sapiens)		4 / 8HIS A 138
TYR A 263
HIS A 113
GLU A 136
 MG  A 901 (-3.2A)
None
MG  A 901 (-3.4A)
None
0.87A24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens)		4 / 8GLU A 262
HIS A 223
HIS A 227
GLU A 224
 ZN  A1916 (-2.0A)
ZN  A1916 (-3.3A)
ZN  A1916 (-3.3A)
ZN  A1916 ( 4.3A)
0.89A13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		4fys AMINOPEPTIDASE N
(Homo
sapiens)		4 / 8GLU A 411
HIS A 388
HIS A 392
GLU A 389
None
0.87A13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		4pj6 LEUCYL-CYSTINYL
AMINOPEPTIDASE
(Homo
sapiens)		4 / 8GLU A 487
HIS A 464
HIS A 468
GLU A 465
 ZN  A1101 ( 1.9A)
ZN  A1101 ( 3.2A)
ZN  A1101 (-3.2A)
LYS  A1102 (-3.4A)
0.83A14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		5iry DESMOCOLLIN-1
(Homo
sapiens)		4 / 8GLU A 402
ASP A 400
TYR A 436
HIS A 439
 CA  A 609 ( 2.1A)
CA  A 609 (-3.0A)
None
None
0.93A20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens)		4 / 8GLU A 393
HIS A 370
HIS A 374
GLU A 371
 ZN  A1001 ( 1.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
0.98A14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		1now BETA-HEXOSAMINIDASE
BETA CHAIN
(Homo
sapiens)		4 / 8GLU A 288
HIS A 350
HIS A 235
GLU A 422
None
0.93A20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		1q7l AMINOACYLASE-1
(Homo
sapiens)		4 / 8GLU A 175
HIS A  80
ASP A 113
GLU A 148
 ZN  A1002 ( 1.9A)
ZN  A1002 ( 3.2A)
ZN  A1002 (-2.5A)
ZN  A1001 (-1.9A)
0.91A19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		2o36 THIMET
OLIGOPEPTIDASE
(Homo
sapiens)		4 / 8GLU A 502
HIS A 473
HIS A 477
GLU A 474
 ZN  A 690 (-2.3A)
ZN  A 690 (-3.4A)
ZN  A 690 (-3.3A)
ZN  A 690 ( 4.1A)
0.89A16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		4 / 8GLU A 411
HIS A 383
HIS A 387
GLU A 384
 ZN  A1628 ( 2.4A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
0.82A18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		4 / 8GLU A 389
HIS A 361
HIS A 365
GLU A 362
 ZN  A1620 ( 2.4A)
3ES  A1611 ( 3.2A)
ZN  A1620 ( 3.2A)
3ES  A1611 (-2.5A)
0.77A17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens)		4 / 8GLU A 667
HIS A 607
HIS A 611
GLU A 608
 ZN  A 771 ( 2.1A)
ZN  A 771 ( 3.4A)
ZN  A 771 ( 3.3A)
RDF  A 817 (-2.4A)
0.76A16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		3fe4 CARBONIC ANHYDRASE 6
(Homo
sapiens)		4 / 8HIS A 138
TYR A 263
HIS A 113
GLU A 136
 MG  A 901 (-3.2A)
None
MG  A 901 (-3.4A)
None
0.90A23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens)		4 / 8GLU A1318
HIS A1295
HIS A1299
GLU A1296
 ZN  A2001 ( 2.2A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
0.88A19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens)		4 / 8GLU A 262
HIS A 223
HIS A 227
GLU A 224
 ZN  A1916 (-2.0A)
ZN  A1916 (-3.3A)
ZN  A1916 (-3.3A)
ZN  A1916 ( 4.3A)
0.90A13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		4fys AMINOPEPTIDASE N
(Homo
sapiens)		4 / 8GLU A 411
HIS A 388
HIS A 392
GLU A 389
None
0.86A13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		4pj6 LEUCYL-CYSTINYL
AMINOPEPTIDASE
(Homo
sapiens)		4 / 8GLU A 487
HIS A 464
HIS A 468
GLU A 465
 ZN  A1101 ( 1.9A)
ZN  A1101 ( 3.2A)
ZN  A1101 (-3.2A)
LYS  A1102 (-3.4A)
0.82A14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		5iry DESMOCOLLIN-1
(Homo
sapiens)		4 / 8GLU A 402
ASP A 400
TYR A 436
HIS A 439
 CA  A 609 ( 2.1A)
CA  A 609 (-3.0A)
None
None
0.91A20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		5syt CAAX PRENYL PROTEASE
1 HOMOLOG
(Homo
sapiens)		5 / 8GLU A 415
HIS A 335
HIS A 459
HIS A 339
GLU A 336
 ZN  A 517 (-2.1A)
ZN  A 517 (-3.2A)
DMS  A 523 (-4.3A)
ZN  A 517 (-3.2A)
ZN  A 517 (-3.9A)
1.24A18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		1now BETA-HEXOSAMINIDASE
BETA CHAIN
(Homo
sapiens)		4 / 7GLU A 288
HIS A 350
HIS A 235
GLU A 422
None
0.94A20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		1q7l AMINOACYLASE-1
(Homo
sapiens)		4 / 7GLU A 175
HIS A  80
ASP A 113
GLU A 148
 ZN  A1002 ( 1.9A)
ZN  A1002 ( 3.2A)
ZN  A1002 (-2.5A)
ZN  A1001 (-1.9A)
0.91A19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		2o36 THIMET
OLIGOPEPTIDASE
(Homo
sapiens)		4 / 7GLU A 502
HIS A 473
HIS A 477
GLU A 474
 ZN  A 690 (-2.3A)
ZN  A 690 (-3.4A)
ZN  A 690 (-3.3A)
ZN  A 690 ( 4.1A)
0.87A16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		4 / 7GLU A 411
HIS A 383
HIS A 387
GLU A 384
 ZN  A1628 ( 2.4A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
0.80A18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		4 / 7GLU A 389
HIS A 361
HIS A 365
GLU A 362
 ZN  A1620 ( 2.4A)
3ES  A1611 ( 3.2A)
ZN  A1620 ( 3.2A)
3ES  A1611 (-2.5A)
0.75A17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens)		4 / 7GLU A 667
HIS A 607
HIS A 611
GLU A 608
 ZN  A 771 ( 2.1A)
ZN  A 771 ( 3.4A)
ZN  A 771 ( 3.3A)
RDF  A 817 (-2.4A)
0.73A16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		3fe4 CARBONIC ANHYDRASE 6
(Homo
sapiens)		4 / 7HIS A 138
TYR A 263
HIS A 113
GLU A 136
 MG  A 901 (-3.2A)
None
MG  A 901 (-3.4A)
None
0.92A23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens)		4 / 7GLU A1318
HIS A1295
HIS A1299
GLU A1296
 ZN  A2001 ( 2.2A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
0.85A19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens)		4 / 7GLU A 262
HIS A 223
HIS A 227
GLU A 224
 ZN  A1916 (-2.0A)
ZN  A1916 (-3.3A)
ZN  A1916 (-3.3A)
ZN  A1916 ( 4.3A)
0.88A13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		4fys AMINOPEPTIDASE N
(Homo
sapiens)		4 / 7GLU A 411
HIS A 388
HIS A 392
GLU A 389
None
0.83A13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		4pj6 LEUCYL-CYSTINYL
AMINOPEPTIDASE
(Homo
sapiens)		4 / 7GLU A 487
HIS A 464
HIS A 468
GLU A 465
 ZN  A1101 ( 1.9A)
ZN  A1101 ( 3.2A)
ZN  A1101 (-3.2A)
LYS  A1102 (-3.4A)
0.80A14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		5iry DESMOCOLLIN-1
(Homo
sapiens)		4 / 7GLU A 402
ASP A 400
TYR A 436
HIS A 439
 CA  A 609 ( 2.1A)
CA  A 609 (-3.0A)
None
None
0.94A20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens)		4 / 7GLU A 393
HIS A 370
HIS A 374
GLU A 371
 ZN  A1001 ( 1.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
0.94A14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		1now BETA-HEXOSAMINIDASE
BETA CHAIN
(Homo
sapiens)		4 / 8GLU A 288
HIS A 350
HIS A 235
GLU A 422
None
0.93A20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		1q7l AMINOACYLASE-1
(Homo
sapiens)		4 / 8GLU A 175
HIS A  80
ASP A 113
GLU A 148
 ZN  A1002 ( 1.9A)
ZN  A1002 ( 3.2A)
ZN  A1002 (-2.5A)
ZN  A1001 (-1.9A)
0.91A19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		2o36 THIMET
OLIGOPEPTIDASE
(Homo
sapiens)		4 / 8GLU A 502
HIS A 473
HIS A 477
GLU A 474
 ZN  A 690 (-2.3A)
ZN  A 690 (-3.4A)
ZN  A 690 (-3.3A)
ZN  A 690 ( 4.1A)
0.87A16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		4 / 8GLU A 411
HIS A 383
HIS A 387
GLU A 384
 ZN  A1628 ( 2.4A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
0.80A18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		4 / 8GLU A 389
HIS A 361
HIS A 365
GLU A 362
 ZN  A1620 ( 2.4A)
3ES  A1611 ( 3.2A)
ZN  A1620 ( 3.2A)
3ES  A1611 (-2.5A)
0.76A17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens)		4 / 8GLU A 667
HIS A 607
HIS A 611
GLU A 608
 ZN  A 771 ( 2.1A)
ZN  A 771 ( 3.4A)
ZN  A 771 ( 3.3A)
RDF  A 817 (-2.4A)
0.73A16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		3fe4 CARBONIC ANHYDRASE 6
(Homo
sapiens)		4 / 8HIS A 138
TYR A 263
HIS A 113
GLU A 136
 MG  A 901 (-3.2A)
None
MG  A 901 (-3.4A)
None
0.89A23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens)		4 / 8GLU A1318
HIS A1295
HIS A1299
GLU A1296
 ZN  A2001 ( 2.2A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
0.86A19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens)		4 / 8GLU A 262
HIS A 223
HIS A 227
GLU A 224
 ZN  A1916 (-2.0A)
ZN  A1916 (-3.3A)
ZN  A1916 (-3.3A)
ZN  A1916 ( 4.3A)
0.88A13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		4fys AMINOPEPTIDASE N
(Homo
sapiens)		4 / 8GLU A 411
HIS A 388
HIS A 392
GLU A 389
None
0.84A13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		4pj6 LEUCYL-CYSTINYL
AMINOPEPTIDASE
(Homo
sapiens)		4 / 8GLU A 487
HIS A 464
HIS A 468
GLU A 465
 ZN  A1101 ( 1.9A)
ZN  A1101 ( 3.2A)
ZN  A1101 (-3.2A)
LYS  A1102 (-3.4A)
0.81A14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		5iry DESMOCOLLIN-1
(Homo
sapiens)		4 / 8GLU A 402
ASP A 400
TYR A 436
HIS A 439
 CA  A 609 ( 2.1A)
CA  A 609 (-3.0A)
None
None
0.95A20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens)		4 / 8GLU A 393
HIS A 370
HIS A 374
GLU A 371
 ZN  A1001 ( 1.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
0.95A14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		5syt CAAX PRENYL PROTEASE
1 HOMOLOG
(Homo
sapiens)		5 / 8GLU A 415
HIS A 335
HIS A 459
HIS A 339
GLU A 336
 ZN  A 517 (-2.1A)
ZN  A 517 (-3.2A)
DMS  A 523 (-4.3A)
ZN  A 517 (-3.2A)
ZN  A 517 (-3.9A)
1.24A18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		1now BETA-HEXOSAMINIDASE
BETA CHAIN
(Homo
sapiens)		4 / 8GLU A 288
HIS A 350
HIS A 235
GLU A 422
None
0.96A20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		1q7l AMINOACYLASE-1
(Homo
sapiens)		4 / 8GLU A 175
HIS A  80
ASP A 113
GLU A 148
 ZN  A1002 ( 1.9A)
ZN  A1002 ( 3.2A)
ZN  A1002 (-2.5A)
ZN  A1001 (-1.9A)
0.92A19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		2o36 THIMET
OLIGOPEPTIDASE
(Homo
sapiens)		4 / 8GLU A 502
HIS A 473
HIS A 477
GLU A 474
 ZN  A 690 (-2.3A)
ZN  A 690 (-3.4A)
ZN  A 690 (-3.3A)
ZN  A 690 ( 4.1A)
0.90A16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		4 / 8GLU A 411
HIS A 383
HIS A 387
GLU A 384
 ZN  A1628 ( 2.4A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
0.83A18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		4 / 8GLU A 389
HIS A 361
HIS A 365
GLU A 362
 ZN  A1620 ( 2.4A)
3ES  A1611 ( 3.2A)
ZN  A1620 ( 3.2A)
3ES  A1611 (-2.5A)
0.78A17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens)		4 / 8GLU A 667
HIS A 607
HIS A 611
GLU A 608
 ZN  A 771 ( 2.1A)
ZN  A 771 ( 3.4A)
ZN  A 771 ( 3.3A)
RDF  A 817 (-2.4A)
0.77A16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		3fe4 CARBONIC ANHYDRASE 6
(Homo
sapiens)		4 / 8HIS A 138
TYR A 263
HIS A 113
GLU A 136
 MG  A 901 (-3.2A)
None
MG  A 901 (-3.4A)
None
0.89A23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens)		4 / 8GLU A1318
HIS A1295
HIS A1299
GLU A1296
 ZN  A2001 ( 2.2A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
0.89A19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens)		4 / 8GLU A 262
HIS A 223
HIS A 227
GLU A 224
 ZN  A1916 (-2.0A)
ZN  A1916 (-3.3A)
ZN  A1916 (-3.3A)
ZN  A1916 ( 4.3A)
0.91A13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		4fys AMINOPEPTIDASE N
(Homo
sapiens)		4 / 8GLU A 411
HIS A 388
HIS A 392
GLU A 389
None
0.87A13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		4pj6 LEUCYL-CYSTINYL
AMINOPEPTIDASE
(Homo
sapiens)		4 / 8GLU A 487
HIS A 464
HIS A 468
GLU A 465
 ZN  A1101 ( 1.9A)
ZN  A1101 ( 3.2A)
ZN  A1101 (-3.2A)
LYS  A1102 (-3.4A)
0.84A14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		5iry DESMOCOLLIN-1
(Homo
sapiens)		4 / 8GLU A 402
ASP A 400
TYR A 436
HIS A 439
 CA  A 609 ( 2.1A)
CA  A 609 (-3.0A)
None
None
0.94A20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens)		4 / 8GLU A 393
HIS A 370
HIS A 374
GLU A 371
 ZN  A1001 ( 1.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
0.97A14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		1now BETA-HEXOSAMINIDASE
BETA CHAIN
(Homo
sapiens)		4 / 8GLU A 288
HIS A 350
HIS A 235
GLU A 422
None
0.92A20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		1q7l AMINOACYLASE-1
(Homo
sapiens)		4 / 8GLU A 175
HIS A  80
ASP A 113
GLU A 148
 ZN  A1002 ( 1.9A)
ZN  A1002 ( 3.2A)
ZN  A1002 (-2.5A)
ZN  A1001 (-1.9A)
0.91A19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		2o36 THIMET
OLIGOPEPTIDASE
(Homo
sapiens)		4 / 8GLU A 502
HIS A 473
HIS A 477
GLU A 474
 ZN  A 690 (-2.3A)
ZN  A 690 (-3.4A)
ZN  A 690 (-3.3A)
ZN  A 690 ( 4.1A)
0.87A16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		4 / 8GLU A 411
HIS A 383
HIS A 387
GLU A 384
 ZN  A1628 ( 2.4A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
0.79A18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		4 / 8GLU A 389
HIS A 361
HIS A 365
GLU A 362
 ZN  A1620 ( 2.4A)
3ES  A1611 ( 3.2A)
ZN  A1620 ( 3.2A)
3ES  A1611 (-2.5A)
0.75A17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens)		4 / 8GLU A 667
HIS A 607
HIS A 611
GLU A 608
 ZN  A 771 ( 2.1A)
ZN  A 771 ( 3.4A)
ZN  A 771 ( 3.3A)
RDF  A 817 (-2.4A)
0.73A16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		3fe4 CARBONIC ANHYDRASE 6
(Homo
sapiens)		4 / 8HIS A 138
TYR A 263
HIS A 113
GLU A 136
 MG  A 901 (-3.2A)
None
MG  A 901 (-3.4A)
None
0.90A23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens)		4 / 8GLU A1318
HIS A1295
HIS A1299
GLU A1296
 ZN  A2001 ( 2.2A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
0.85A19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens)		4 / 8GLU A 262
HIS A 223
HIS A 227
GLU A 224
 ZN  A1916 (-2.0A)
ZN  A1916 (-3.3A)
ZN  A1916 (-3.3A)
ZN  A1916 ( 4.3A)
0.88A13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		4fys AMINOPEPTIDASE N
(Homo
sapiens)		4 / 8GLU A 411
HIS A 388
HIS A 392
GLU A 389
None
0.84A13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		4pj6 LEUCYL-CYSTINYL
AMINOPEPTIDASE
(Homo
sapiens)		4 / 8GLU A 487
HIS A 464
HIS A 468
GLU A 465
 ZN  A1101 ( 1.9A)
ZN  A1101 ( 3.2A)
ZN  A1101 (-3.2A)
LYS  A1102 (-3.4A)
0.81A14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens)		4 / 8GLU A 393
HIS A 370
HIS A 374
GLU A 371
 ZN  A1001 ( 1.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
0.94A14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		1k1b B-CELL LYMPHOMA
3-ENCODED PROTEIN
(Homo
sapiens)		4 / 6THR A 174
VAL A 172
CYH A 212
SER A 209
None
1.11A23.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL
(Homo
sapiens)		4 / 6THR A  66
VAL A  67
CYH A 278
SER A 280
None
0.40A66.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		1x5m CALCYCLIN-BINDING
PROTEIN
(Homo
sapiens)		4 / 6THR A  54
LEU A  77
CYH A  99
SER A  86
None
1.13A17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		2ej8 DCC-INTERACTING
PROTEIN 13 ALPHA
(Homo
sapiens)		4 / 6THR A  64
VAL A  63
LEU A  84
SER A 134
None
1.26A19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		2km6 NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 7
(Homo
sapiens)		4 / 6THR A  73
VAL A  74
LEU A  15
CYH A  86
None
1.20A14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		2q3z TRANSGLUTAMINASE 2
(Homo
sapiens)		4 / 6THR A 286
VAL A 287
LEU A 261
CYH A 193
None
1.17A20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		2yuy RHO GTPASE
ACTIVATING PROTEIN
21
(Homo
sapiens)		4 / 6THR A  13
VAL A  12
LEU A 112
SER A 115
None
1.11A14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		3bsx PUMILIO HOMOLOG 1
(Homo
sapiens)		4 / 6VAL A1082
LEU A1097
GLU A1100
SER A1073
None
1.21A21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		3hd6 AMMONIUM TRANSPORTER
RH TYPE C
(Homo
sapiens)		4 / 6THR A 160
VAL A 159
GLU A 166
CYH A 131
None
1.22A21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		4bej DYNAMIN 1-LIKE
PROTEIN
(Homo
sapiens)		4 / 6THR A 259
VAL A 258
GLU A 265
SER A  44
None
1.09A22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		4lhu 9C2 TCR GAMMA CHAIN
(Homo
sapiens)		4 / 6VAL G 201
LEU G 179
GLU G 172
SER G 205
None
0.97A20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		4n78 ABL INTERACTOR 2
WISKOTT-ALDRICH
SYNDROME PROTEIN
FAMILY MEMBER 1
(Homo
sapiens)		4 / 6THR F  96
VAL F  97
LEU D  83
GLU D  88
None
1.23A19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		4tlg SEC14-LIKE PROTEIN 4
(Homo
sapiens)		4 / 6THR A 354
VAL A 302
LEU A 197
SER A 352
None
None
None
EDO  A 503 (-2.7A)
1.07A24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		5tfm CADHERIN-23
(Homo
sapiens)		4 / 6THR A 806
VAL A 791
GLU A 786
CYH A 840
None
1.11A13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		5yt6 TAX1-BINDING PROTEIN
1
(Homo
sapiens)		4 / 6THR F  59
VAL F  57
GLU F  42
CYH F  37
None
None
None
ZN  F 101 (-2.3A)
1.21A6.95