POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		2yu1 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1A
(Homo
sapiens)		6 / 10LEU A 201
THR A 209
HIS A 212
ASP A 214
ILE A 278
HIS A 284
None
AKG  A 701 (-3.1A)
AKG  A 701 ( 3.5A)
FE2  A 600 ( 2.1A)
None
FE2  A 600 ( 3.4A)
0.90A21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		2yu1 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1A
(Homo
sapiens)		6 / 10THR A 209
HIS A 212
ASP A 214
LYS A 229
ILE A 278
HIS A 284
AKG  A 701 (-3.1A)
AKG  A 701 ( 3.5A)
FE2  A 600 ( 2.1A)
AKG  A 701 (-2.9A)
None
FE2  A 600 ( 3.4A)
0.95A21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		3al5 JMJC
DOMAIN-CONTAINING
PROTEIN C2ORF60
(Homo
sapiens)		5 / 10HIS A 160
ASP A 162
LYS A 175
ILE A 229
HIS A 235
None
0.52A25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		3al5 JMJC
DOMAIN-CONTAINING
PROTEIN C2ORF60
(Homo
sapiens)		5 / 10TYR A 106
HIS A 160
ASP A 162
ILE A 229
HIS A 235
None
0.97A25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		3k3n PHD FINGER PROTEIN 8
(Homo
sapiens)		5 / 10LEU A 236
HIS A 247
ASP A 249
ILE A 313
HIS A 319
None
FE2  A   1 (-3.4A)
FE2  A   1 (-2.5A)
None
FE2  A   1 (-3.3A)
0.72A22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		3k3n PHD FINGER PROTEIN 8
(Homo
sapiens)		6 / 10THR A 244
HIS A 247
ASP A 249
LYS A 264
ILE A 313
HIS A 319
None
FE2  A   1 (-3.4A)
FE2  A   1 (-2.5A)
None
None
FE2  A   1 (-3.3A)
1.00A22.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		3kcx HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR
(Homo
sapiens)		10 / 10TYR A 145
LEU A 188
THR A 196
HIS A 199
ASP A 201
LYS A 214
ILE A 273
HIS A 279
ILE A 281
TRP A 296
None
CQL  A   1 (-4.7A)
CQL  A   1 (-3.8A)
FE2  A1350 ( 3.2A)
FE2  A1350 (-2.5A)
CQL  A   1 (-3.6A)
CQL  A   1 (-4.8A)
CQL  A   1 ( 3.2A)
CQL  A   1 (-3.4A)
CQL  A   1 (-4.7A)
0.02A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		3kv4 PHD FINGER PROTEIN 8
(Homo
sapiens)		7 / 10LEU A 236
THR A 244
HIS A 247
ASP A 249
LYS A 264
ILE A 313
HIS A 319
OGA  A5798 ( 4.8A)
OGA  A5798 (-3.4A)
FE2  A 450 ( 3.4A)
FE2  A 450 ( 2.5A)
OGA  A5798 (-2.8A)
None
FE2  A 450 ( 3.4A)
0.98A20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		3kv6 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1D
(Homo
sapiens)		6 / 10LEU A 271
THR A 279
HIS A 282
ASP A 284
LYS A 299
HIS A 354
AKG  A 702 ( 4.7A)
AKG  A 702 (-4.2A)
FE2  A 491 ( 3.6A)
FE2  A 491 ( 2.6A)
AKG  A 702 (-3.6A)
FE2  A 491 (-3.4A)
0.93A21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		3ld8 BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6
(Homo
sapiens)		5 / 10THR A 184
HIS A 187
ASP A 189
LYS A 204
HIS A 273
None
FE  A 601 (-3.9A)
FE  A 601 (-3.3A)
None
FE  A 601 (-3.7A)
0.74A26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		3ld8 BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6
(Homo
sapiens)		5 / 10TYR A 131
THR A 184
HIS A 187
ASP A 189
HIS A 273
None
None
FE  A 601 (-3.9A)
FE  A 601 (-3.3A)
FE  A 601 (-3.7A)
1.24A26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		3pua PHD FINGER PROTEIN 2
(Homo
sapiens)		6 / 10LEU A 238
THR A 246
HIS A 249
ASP A 251
LYS A 266
ILE A 315
OGA  A 454 ( 3.8A)
OGA  A 454 (-3.8A)
NI  A   2 ( 3.3A)
NI  A   2 ( 2.5A)
OGA  A 454 (-3.0A)
None
0.90A23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		3pua PHD FINGER PROTEIN 2
(Homo
sapiens)		5 / 10LEU A 238
THR A 323
HIS A 249
ASP A 251
ILE A 315
OGA  A 454 ( 3.8A)
OGA  A 454 (-2.9A)
NI  A   2 ( 3.3A)
NI  A   2 ( 2.5A)
None
1.23A23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		3u78 LYSINE-SPECIFIC
DEMETHYLASE 7
(Homo
sapiens)		6 / 10LEU A 271
THR A 279
HIS A 282
ASP A 284
LYS A 299
HIS A 354
None
AKG  A 701 (-3.6A)
NI  A 702 ( 3.4A)
NI  A 702 (-2.6A)
AKG  A 701 (-3.2A)
NI  A 702 ( 3.5A)
0.91A21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		3uyj LYSINE-SPECIFIC
DEMETHYLASE 8
(Homo
sapiens)		7 / 10TYR A 272
HIS A 321
ASP A 323
LYS A 336
ILE A 394
HIS A 400
TRP A 414
AKG  A 601 (-4.7A)
NI  A 501 ( 3.2A)
NI  A 501 ( 2.4A)
AKG  A 601 (-2.6A)
None
NI  A 501 ( 3.4A)
AKG  A 601 (-4.4A)
0.80A27.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		4c8d LYSINE-SPECIFIC
DEMETHYLASE 3B
(Homo
sapiens)		5 / 10THR A1557
HIS A1560
ASP A1562
ILE A1683
HIS A1689
OGA  A2722 (-3.3A)
MN  A2721 ( 3.3A)
MN  A2721 ( 3.0A)
None
MN  A2721 ( 3.2A)
0.50A19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		4nhy 2-OXOGLUTARATE AND
IRON-DEPENDENT
OXYGENASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		5 / 10TYR A 146
HIS A 155
ASP A 157
HIS A 218
TRP A 236
None
MN  A 601 (-3.5A)
MN  A 601 ( 2.5A)
MN  A 601 ( 3.4A)
None
1.34A19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		4qkf ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB
HOMOLOG 7,
MITOCHONDRIAL
(Homo
sapiens)		5 / 10LEU A 110
HIS A 121
ASP A 123
HIS A 177
ILE A 179
OGA  A 301 ( 4.6A)
MN  A 300 ( 3.4A)
MN  A 300 (-2.9A)
MN  A 300 ( 3.5A)
None
1.10A22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		5gu6 ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 44
(Homo
sapiens)		5 / 10LEU A 258
THR A 264
HIS A 323
ILE A 294
ILE A 265
None
1.17A22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		5nfn JMJC
DOMAIN-CONTAINING
PROTEIN 7
(Homo
sapiens)		7 / 10TYR A 127
THR A 175
HIS A 178
ASP A 180
LYS A 193
HIS A 277
TRP A 291
None
AKG  A 502 (-3.3A)
MN  A 501 ( 3.2A)
MN  A 501 ( 2.5A)
AKG  A 502 (-3.3A)
MN  A 501 ( 3.3A)
AKG  A 502 (-4.5A)
0.74Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		6fqc BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6
(Homo
sapiens)		5 / 10TYR A 131
THR A 184
HIS A 187
ASP A 189
HIS A 273
None
None
MN  A 501 ( 3.4A)
MN  A 501 ( 2.6A)
MN  A 501 ( 3.1A)
1.16Aundetectable