POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOU_A_CQAA402_0
(HISTAMINE
N-METHYLTRANSFERASE)		1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens)		9 / 12GLU A  28
GLN A  94
GLN A 143
TYR A 146
TYR A 147
VAL A 173
TRP A 179
TRP A 183
CYH A 196
None
SAH  A 400 (-3.8A)
None
QUN  A 500 (-3.3A)
QUN  A 500 ( 3.6A)
None
QUN  A 500 (-3.6A)
QUN  A 500 (-4.9A)
QUN  A 500 (-3.6A)
0.51A99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOU_A_CQAA402_0
(HISTAMINE
N-METHYLTRANSFERASE)		1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens)		9 / 12GLU A  28
GLN A  94
GLN A 143
TYR A 146
VAL A 173
TRP A 179
TRP A 183
CYH A 196
GLU A 246
None
SAH  A 400 (-3.8A)
None
QUN  A 500 (-3.3A)
None
QUN  A 500 (-3.6A)
QUN  A 500 (-4.9A)
QUN  A 500 (-3.6A)
QUN  A 500 (-3.9A)
0.86A99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOU_A_CQAA402_0
(HISTAMINE
N-METHYLTRANSFERASE)		1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens)		8 / 12PHE A  19
GLN A  94
TYR A 146
TYR A 147
VAL A 173
TRP A 179
TRP A 183
CYH A 196
SAH  A 400 (-3.9A)
SAH  A 400 (-3.8A)
QUN  A 500 (-3.3A)
QUN  A 500 ( 3.6A)
None
QUN  A 500 (-3.6A)
QUN  A 500 (-4.9A)
QUN  A 500 (-3.6A)
0.78A99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOU_A_CQAA402_0
(HISTAMINE
N-METHYLTRANSFERASE)		1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens)		8 / 12PHE A  19
GLN A  94
TYR A 146
VAL A 173
TRP A 179
TRP A 183
CYH A 196
GLU A 246
SAH  A 400 (-3.9A)
SAH  A 400 (-3.8A)
QUN  A 500 (-3.3A)
None
QUN  A 500 (-3.6A)
QUN  A 500 (-4.9A)
QUN  A 500 (-3.6A)
QUN  A 500 (-3.9A)
1.07A99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOU_A_CQAA402_0
(HISTAMINE
N-METHYLTRANSFERASE)		1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens)		5 / 12PHE A  22
GLN A 143
TYR A 146
CYH A 196
GLU A 246
None
None
QUN  A 500 (-3.3A)
QUN  A 500 (-3.6A)
QUN  A 500 (-3.9A)
1.37A99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOU_A_CQAA402_0
(HISTAMINE
N-METHYLTRANSFERASE)		1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens)		5 / 12PHE A  22
GLN A 143
TYR A 146
TYR A 147
CYH A 196
None
None
QUN  A 500 (-3.3A)
QUN  A 500 ( 3.6A)
QUN  A 500 (-3.6A)
1.43A99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOU_A_CQAA402_0
(HISTAMINE
N-METHYLTRANSFERASE)		1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens)		5 / 12PHE A  22
GLN A 143
TYR A 146
VAL A 172
CYH A 196
None
None
QUN  A 500 (-3.3A)
None
QUN  A 500 (-3.6A)
1.45A99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens)		6 / 8ASP A 180
TRP A 183
LYS A 184
GLY A 187
PHE A 190
THR A 247
None
QUN  A 500 (-4.9A)
None
None
None
None
1.07A99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens)		6 / 8ASP A 180
TRP A 183
LYS A 184
PHE A 190
TYR A 198
THR A 247
None
QUN  A 500 (-4.9A)
None
None
None
None
1.09A99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens)		5 / 8TRP A 183
LYS A 181
PHE A 190
TYR A 198
THR A 247
QUN  A 500 (-4.9A)
None
None
None
None
1.25A99.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		1n76 LACTOFERRIN
(Homo
sapiens)		4 / 8ASP A 570
GLY A 556
ASP A 560
THR A 638
None
0.98A18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		1pou OCT-1
(Homo
sapiens)		4 / 8ASP A  73
TRP A  70
GLY A  35
THR A  46
None
0.99A14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E
(Homo
sapiens)		4 / 8ASP A 217
LYS A 221
GLY A 186
THR A 161
None
1.03A19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		3ddu PROLYL ENDOPEPTIDASE
(Homo
sapiens)		4 / 8ASP A 582
GLY A 592
ASP A 598
TYR A 599
None
0.97A16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		4md8 CASEIN KINASE II
SUBUNIT ALPHA
(Homo
sapiens)		4 / 8ASP E  14
GLY E 151
ASP E 145
TYR E  12
None
0.92A21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		5dzz DESMOPLAKIN
(Homo
sapiens)		4 / 8ASP A2136
GLY A2095
PHE A2096
ASP A2098
None
1.03A20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		5oom 39S RIBOSOMAL
PROTEIN L23,
MITOCHONDRIAL
39S RIBOSOMAL
PROTEIN L47,
MITOCHONDRIAL
(Homo
sapiens;
Homo
sapiens)		4 / 8ASP Y  70
TRP Y  74
GLY Y  75
PHE U 111
None
0.88A20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens)		4 / 8ASP A 474
GLY A 122
PHE A 123
TYR A 471
None
0.85A22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		6ccu GLUCOSE-INDUCED
DEGRADATION PROTEIN
4 HOMOLOG
(Homo
sapiens)		4 / 8ASP A 196
LYS A 200
GLY A 203
PHE A 208
None
1.04Aundetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOU_B_CQAB400_0
(HISTAMINE
N-METHYLTRANSFERASE)		1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens)		5 / 12GLN A  94
TYR A 146
VAL A 173
TRP A 183
PHE A  22
SAH  A 400 (-3.8A)
QUN  A 500 (-3.3A)
None
QUN  A 500 (-4.9A)
None
1.42A99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOU_B_CQAB400_0
(HISTAMINE
N-METHYLTRANSFERASE)		1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens)		9 / 12GLU A  28
GLN A  94
GLN A 143
TYR A 146
VAL A 173
TRP A 183
CYH A 196
PHE A 243
GLU A 246
None
SAH  A 400 (-3.8A)
None
QUN  A 500 (-3.3A)
None
QUN  A 500 (-4.9A)
QUN  A 500 (-3.6A)
QUN  A 500 (-4.1A)
QUN  A 500 (-3.9A)
0.87A99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOU_B_CQAB400_0
(HISTAMINE
N-METHYLTRANSFERASE)		1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens)		10 / 12GLU A  28
SER A  91
GLN A  94
GLN A 143
TYR A 146
TYR A 147
VAL A 173
TRP A 183
CYH A 196
PHE A 243
None
SAH  A 400 (-4.7A)
SAH  A 400 (-3.8A)
None
QUN  A 500 (-3.3A)
QUN  A 500 ( 3.6A)
None
QUN  A 500 (-4.9A)
QUN  A 500 (-3.6A)
QUN  A 500 (-4.1A)
0.64A99.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB400_0
(HISTAMINE
N-METHYLTRANSFERASE)		2b5i INTERLEUKIN-2
RECEPTOR BETA CHAIN
CYTOKINE RECEPTOR
COMMON GAMMA CHAIN
(Homo
sapiens;
Homo
sapiens)		5 / 12SER C 146
GLN C 147
GLN B 162
VAL C 180
TRP C 152
None
1.37A19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB400_0
(HISTAMINE
N-METHYLTRANSFERASE)		4zch TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13,TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13B,TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13B
(Homo
sapiens)		5 / 12SER A 102
GLN A  60
TYR A 254
VAL A 108
PHE A 353
None
1.37A21.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens)		4 / 7TRP A 183
GLY A 187
PHE A 190
THR A 247
QUN  A 500 (-4.9A)
None
None
None
1.04A99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens)		4 / 7TRP A 183
PHE A 190
TYR A 198
THR A 247
QUN  A 500 (-4.9A)
None
None
None
1.03A99.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens)		4 / 7GLY A 213
PHE A 310
PRO A 311
ASP A 313
None
0.85A16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		3k77 DNA REPAIR PROTEIN
XRCC1
(Homo
sapiens)		4 / 7GLY A  64
PHE A 142
PRO A 141
ASP A 139
None
1.17A18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		3wsy SORTILIN-RELATED
RECEPTOR
(Homo
sapiens)		4 / 7GLY A 331
PHE A 330
ASP A 304
TYR A 258
None
1.15A18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		4ig9 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens)		4 / 7PHE A 287
PRO A 288
ASP A 289
TYR A 301
None
1.01A21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		4or2 SOLUBLE CYTOCHROME
B562, METABOTROPIC
GLUTAMATE RECEPTOR 1
(Escherichia
coli;
Homo
sapiens)		4 / 7PRO A1056
ASP A1060
TYR A1105
THR A 653
None
None
None
CLR  A1905 (-3.4A)
1.01A19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		4zzh NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens)		4 / 7PHE A 287
PRO A 288
ASP A 289
TYR A 301
None
1.08A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		5btr NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens)		4 / 7PHE A 287
PRO A 288
ASP A 289
TYR A 301
None
0.88A19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		6cfs PHOSPHOMANNOMUTASE 1
(Homo
sapiens)		4 / 7GLY A  49
PHE A  18
ASP A  19
THR A 246
None
None
MG  A 301 (-2.4A)
None
1.17Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		6eoq DIPEPTIDYL PEPTIDASE
9
(Homo
sapiens)		4 / 7GLY A 780
PRO A 774
ASP A 772
THR A 767
None
1.04Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		1jxk ALPHA-AMYLASE,
SALIVARY
(Homo
sapiens)		4 / 8GLY A  38
LEU A  16
VAL A  42
TYR A  94
None
0.92A19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		2aex COPROPORPHYRINOGEN
III OXIDASE,
MITOCHONDRIAL
(Homo
sapiens)		4 / 8GLY A 336
GLY A 333
LEU A 446
VAL A 445
None
0.91A20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		2qqo NEUROPILIN-2
(Homo
sapiens)		4 / 8GLY A 443
GLU A 588
LEU A 492
VAL A 490
None
0.93A18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		2yl2 ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens)		5 / 8GLY A 352
GLY A 278
GLU A 251
TYR A 454
LEU A 475
None
1.19A19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		3dad FH1/FH2
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		5 / 8GLY A 193
GLY A 185
LEU A 225
VAL A 228
TYR A 232
None
1.26A20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		3fwv HSC70/HSP90-ORGANIZI
NG PROTEIN
(Homo
sapiens)		4 / 8GLY A 289
GLU A 294
VAL A 263
TYR A 261
None
0.85A20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		1bpv TITIN
(Homo
sapiens)		4 / 7GLU A  73
TYR A  72
GLY A  46
ARG A  41
None
0.98A15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		1ex0 COAGULATION FACTOR
XIII A CHAIN
(Homo
sapiens)		4 / 7GLU A 377
ARG A 326
ARG A 333
LYS A 467
None
1.05A17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		1fbv SIGNAL TRANSDUCTION
PROTEIN CBL
(Homo
sapiens)		4 / 7GLU A 369
GLU A 366
TYR A 368
GLY A 218
None
1.03A22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		1y8p [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 3
(Homo
sapiens)		4 / 7GLU A 258
TYR A 260
ARG A 263
GLY A 290
None
0.82A20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		1y8p [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 3
(Homo
sapiens)		4 / 7GLU A 261
TYR A 260
ARG A 263
GLY A 290
None
1.05A20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		2eqm PHD FINGER PROTEIN
20-LIKE 1
(Homo
sapiens)		4 / 7GLU A  55
GLU A  27
GLY A  23
ARG A  39
None
0.90A19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		3d4j DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Homo
sapiens)		4 / 7GLU A  30
GLU A  29
ARG A  27
GLY A 178
None
1.02A19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		4a14 KINESIN-LIKE PROTEIN
KIF7
(Homo
sapiens)		4 / 7GLU A  65
ARG A  18
GLY A 115
ARG A 119
None
ADP  A1345 (-3.6A)
None
None
1.07A20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		4c0a IQ MOTIF AND SEC7
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		4 / 7GLU A 507
GLY A 457
ARG A 504
LYS A 501
None
1.02A21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		4dkd INTERLEUKIN-34
(Homo
sapiens)		4 / 7GLU A 173
TYR A 176
GLY A  39
ARG A  42
None
1.02A19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		4g1t INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 2
(Homo
sapiens)		4 / 7GLU A 354
GLU A 351
TYR A 355
LYS A 359
None
0.95A20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		4wlp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5
(Homo
sapiens)		4 / 7GLU A 177
TYR A 176
ARG A  73
GLY A 189
None
1.03A22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		5lsi KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens)		4 / 7GLU E  66
GLU E  67
GLY E  61
ARG E  69
None
0.92A14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens)		4 / 7GLU A4206
TYR A4205
GLY A4254
ARG A4255
None
0.93A4.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		5wdh KINESIN-LIKE PROTEIN
KIFC1
(Homo
sapiens)		4 / 7GLU A 386
ARG A 316
GLY A 432
ARG A 436
None
ADP  A 801 (-3.6A)
None
UNX  A 805 ( 2.9A)
0.92A17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		5wy5 NON-STRUCTURAL
MAINTENANCE OF
CHROMOSOMES ELEMENT
1 HOMOLOG
(Homo
sapiens)		4 / 7GLU A  30
GLU A  29
ARG A  73
LYS A  72
None
0.91A22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		6fae IQ MOTIF AND SEC7
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens)		4 / 7GLU A 507
GLY A 457
ARG A 504
LYS A 501
None
1.03Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		3dad FH1/FH2
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		4 / 8GLY A 193
LEU A 225
VAL A 228
TYR A 232
None
0.70A20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		4bdu GREEN FLUORESCENT
PROTEIN, APOPTOSIS
REGULATOR BAX
(Aequorea
victoria;
Homo
sapiens)		4 / 8GLY A  10
GLY A  35
LEU A  42
TYR A  39
None
0.90A23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		4hxq ARGINASE-1
(Homo
sapiens)		4 / 8GLY A 310
TYR A 254
LEU A 258
GLU A 262
None
0.85A21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		4hxq ARGINASE-1
(Homo
sapiens)		4 / 8TYR A 254
LEU A 258
GLU A 262
TYR A 265
None
0.57A21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1
(Homo
sapiens)		4 / 8GLY A 268
GLY A 304
TYR A 430
GLU A 303
None
0.89A20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		4ztu DNA POLYMERASE
SUBUNIT GAMMA-2,
MITOCHONDRIAL
(Homo
sapiens)		4 / 8GLY B 327
GLY B 324
TYR B 193
VAL B 200
None
0.86A19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		5ao5 C-TYPE MANNOSE
RECEPTOR 2
(Homo
sapiens)		4 / 8GLY A 100
GLY A  97
TYR A 110
LEU A 117
None
0.88A19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		5c5s UNCONVENTIONAL
MYOSIN-IXB
(Homo
sapiens)		4 / 8TYR A 207
LEU A 211
VAL A 214
GLU A 215
None
0.46A21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		5f9s SERINE--PYRUVATE
AMINOTRANSFERASE
(Homo
sapiens)		4 / 8GLY A 103
GLY A 106
VAL A 162
GLU A 157
None
0.56A19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G
(Homo
sapiens)		4 / 8GLU A1325
GLU A1322
TYR A1321
LYS A1365
None
0.89A21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		1y8p [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 3
(Homo
sapiens)		4 / 8GLU A 258
TYR A 260
ARG A 263
GLY A 290
None
1.00A20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		1y8p [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 3
(Homo
sapiens)		4 / 8GLU A 261
TYR A 260
ARG A 263
GLY A 290
None
1.06A20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		2eqm PHD FINGER PROTEIN
20-LIKE 1
(Homo
sapiens)		4 / 8GLU A  55
GLU A  27
GLY A  23
ARG A  39
None
0.79A19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		2l11 CHROMOBOX PROTEIN
HOMOLOG 3
(Homo
sapiens)		4 / 8GLU A  38
GLU A  19
TYR A  20
ARG A  11
None
1.05A15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		2yu6 YTH
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens)		4 / 8GLU A 125
TYR A  10
GLY A   7
ARG A   9
None
1.05A17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		3d4j DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Homo
sapiens)		4 / 8GLU A  30
GLU A  29
ARG A  27
GLY A 178
None
0.82A19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		3fo5 THIOESTERASE,
ADIPOSE ASSOCIATED,
ISOFORM BFIT2
(Homo
sapiens)		4 / 8GLU A 521
ARG A 523
GLY A 525
ARG A 524
None
1.06A22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		3keh GLUCOCEREBROSIDASE
(Homo
sapiens)		4 / 8SER A  13
GLU A  41
TYR A  40
GLY A 421
None
0.99A18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		3ld8 BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6
(Homo
sapiens)		4 / 8GLU A 122
GLU A 119
TYR A 120
GLY A 178
None
GOL  A 339 (-4.3A)
None
None
0.82A21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		4dkd INTERLEUKIN-34
(Homo
sapiens)		4 / 8GLU A 173
TYR A 176
GLY A  39
ARG A  42
None
1.00A19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		4wau CENTROMERE PROTEIN M
(Homo
sapiens)		4 / 8SER A 126
GLU A  82
GLY A  22
LYS A  50
None
0.89A19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		4x90 GROUP XV
PHOSPHOLIPASE A2
(Homo
sapiens)		4 / 8SER A 334
TYR A 173
ARG A 177
GLY A 283
None
0.94A18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		5lsi KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens)		4 / 8GLU E  66
GLU E  67
GLY E  61
ARG E  69
None
1.03A14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		5lu2 14-3-3 PROTEIN SIGMA
(Homo
sapiens)		4 / 8GLU A  86
GLU A  83
TYR A  84
ARG A  85
None
0.86A23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		5uem 354NC37 FAB HEAVY
CHAIN
354NC37 FAB LIGHT
CHAIN
(Homo
sapiens;
Homo
sapiens)		4 / 8SER H  93
GLU H  46
GLY L  94
LYS L   1
None
1.04Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		5yh3 EXTRACELLULAR
SERINE/THREONINE
PROTEIN KINASE
FAM20C
(Homo
sapiens)		4 / 8SER C 368
ARG C 459
GLY C 480
ARG C 481
None
1.03Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		1rx0 ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 8,
MITOCHONDRIAL
(Homo
sapiens)		4 / 8GLY A  63
GLY A  74
ILE A  69
LEU A 127
None
0.85A21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens)		4 / 8GLY A 293
GLY A 288
ILE A 121
GLU A 291
None
0.84A21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		2q4v DIAMINE
ACETYLTRANSFERASE 2
(Homo
sapiens)		4 / 8GLY A 106
GLY A  73
GLU A  23
LEU A  20
ACO  A 306 (-3.2A)
None
None
None
0.79A20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens)		4 / 8GLY A 212
ILE A 218
GLU A 204
LEU A 208
None
0.82A22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		4gxb SORTING NEXIN-17
(Homo
sapiens)		4 / 8GLY A 340
GLY A 332
LEU A 329
GLU A 343
None
0.73A21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens)		4 / 8GLY B 103
GLY B 156
LEU B 284
LEU B 287
None
0.76A22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		5k7b BECLIN-2
(Homo
sapiens)		4 / 8GLU A 165
LEU A 166
LEU A 169
GLU A 170
None
0.34A16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		5l7d SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG
(Escherichia
coli;
Homo
sapiens)		4 / 8GLY A 299
GLY A 214
ILE A 215
LEU A 197
None
0.83A18.07