POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		1dql IGM MEZ
IMMUNOGLOBULIN
(Homo
sapiens)		4 / 8TYR L  36
TYR L  49
LEU L  89
TRP L  95
None
0.69A59.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		1ldk CULLIN HOMOLOG
(Homo
sapiens)		4 / 8TYR A 377
LEU A 336
LEU A 380
GLU A 306
None
1.01A20.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		1mi5 TCR ALPHA CHAIN
(Homo
sapiens)		5 / 8TYR D  88
LEU D  82
LEU D 112
SER D  12
GLU D  15
None
1.21A30.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		1t44 CHIMERA OF GELSOLIN
DOMAIN 1 AND
C-TERMINAL DOMAIN OF
THYMOSIN BETA-4
(Homo
sapiens;
Mus
musculus)		4 / 8TYR G  59
LEU G  41
LEU G 138
TRP G  88
None
1.09A20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		1t8t HEPARAN SULFATE
D-GLUCOSAMINYL
3-O-SULFOTRANSFERASE
3A1
(Homo
sapiens)		4 / 8TYR A 395
TYR A 387
LEU A 392
GLU A 385
None
1.00A18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens)		4 / 8HIS A 573
TYR A 572
SER A 390
GLU A 457
None
1.01A16.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		2d7t ANTI
POLYHYDROXYBUTYRATE
ANTIBODY FV, LIGHT
CHAIN
(Homo
sapiens)		4 / 8HIS L  34
TYR L  36
TYR L  49
LEU L  89
None
0.43A33.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		2de0 ALPHA-(1,6)-FUCOSYLT
RANSFERASE
(Homo
sapiens)		4 / 8LEU X 306
LEU X 316
GLU X 477
TRP X 326
None
0.77A15.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		2eiz ANTI-LYSOZYME
ANTIBODY FV REGION
(Homo
sapiens)		4 / 8HIS A  34
TYR A  36
TYR A  49
SER A  91
None
0.95A64.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens)		4 / 8LEU I 416
LEU I 173
GLU I 394
TRP I 460
None
None
None
NGT  A  21 (-3.7A)
1.07A20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		2kv2 BLOOM SYNDROME
PROTEIN
(Homo
sapiens)		4 / 8TYR A  76
LEU A  10
LEU A  73
GLU A  42
None
0.98A17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		2o2f APOPTOSIS REGULATOR
BCL-2
(Homo
sapiens)		4 / 8TYR A 199
LEU A  94
GLU A 197
TRP A 192
LI0  A1000 (-3.4A)
None
None
None
1.02A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		2ou2 HISTONE
ACETYLTRANSFERASE
HTATIP
(Homo
sapiens)		4 / 8TYR A 198
TYR A 209
LEU A 224
GLU A 212
None
1.01A18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens)		4 / 8TYR A 464
LEU A 287
LEU A 460
SER A 280
735  A 469 (-4.6A)
None
735  A 469 (-4.3A)
735  A 469 (-2.8A)
1.07A20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		3tu5 GELSOLIN,PROTEIN
CORDON-BLEU,THYMOSIN
BETA-4
(Homo
sapiens;
Mus
musculus)		4 / 8TYR B  35
LEU B  17
LEU B 114
TRP B  64
None
1.00A22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		4hou INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 1
(Homo
sapiens)		4 / 8HIS A  55
LEU A  58
LEU A  81
SER A  51
None
1.04A22.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		4ma3 C2095 LIGHT CHAIN
(Homo
sapiens;
Oryctolagus
cuniculus)		4 / 8TYR L  37
TYR L  50
LEU L  90
SER L  92
None
0.54A76.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		4owt INTEGRATOR COMPLEX
SUBUNIT 3
(Homo
sapiens)		4 / 8HIS A 219
TYR A 212
LEU A 225
LEU A 215
None
1.12A16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens)		4 / 8TYR A 152
TYR A 146
LEU A 142
LEU A 156
None
0.99A21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		4uf4 CARBOXYPEPTIDASE A1
(Homo
sapiens)		4 / 8TYR A 308
TYR A 387
LEU A  96
GLU A  91
None
1.11A20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		4ufs LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
(Homo
sapiens)		4 / 8HIS A 128
TYR A 152
LEU A 126
GLU A 132
None
1.05A19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_2
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION
CHIMERA OF IG
GAMMA-1 CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		4yzf BAND 3 ANION
TRANSPORT PROTEIN
(Homo
sapiens)		4 / 5GLU A 758
TYR A 392
PRO A 391
ASP A 396
None
1.39A11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_2
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION
CHIMERA OF IG
GAMMA-1 CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		6bbp CYTOHESIN-3,ADP-RIBO
SYLATION FACTOR 6
(Homo
sapiens;
Mus
musculus)		4 / 5TYR A 295
GLU A 297
PRO A 304
ASP A 301
4IP  A 603 (-4.5A)
None
None
None
1.37A14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_2
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION
CHIMERA OF IG
GAMMA-1 CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		6d6u GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
(Homo
sapiens)		4 / 5TYR B 340
TYR B 344
PRO B 147
ASP B 145
None
1.48A15.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I7Z_C_COCC302_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		5b8c PEMBROLIZUMAB LIGHT
CHAIN VARIABLE
REGION (PEMVL)
(Homo
sapiens)		5 / 9TYR A  34
HIS A  38
TYR A  40
TYR A  53
SER A  95
None
1.07A39.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_C_COCC302_2
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION
CHIMERA OF IG
GAMMA-1 CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		4yzf BAND 3 ANION
TRANSPORT PROTEIN
(Homo
sapiens)		4 / 4GLU A 758
TYR A 392
PRO A 391
ASP A 396
None
1.32A11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_C_COCC302_2
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION
CHIMERA OF IG
GAMMA-1 CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		5mc5 XAA-PRO DIPEPTIDASE
(Homo
sapiens)		4 / 4GLU A 131
TYR A 128
PRO A  98
ASP A 130
None
1.50A17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		1k3b DIPEPTYDIL-PEPTIDASE
I EXCLUSION DOMAIN
DIPEPTYDIL-PEPTIDASE
I LIGHT CHAIN
(Homo
sapiens)		4 / 7ALA A   4
TYR A  83
TYR B 235
PHE A  80
None
1.20A20.81
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens)		4 / 7ALA A 208
TYR A 193
TYR A  59
PHE A 217
None
SAM  A 304 (-4.2A)
None
None
1.20A19.40
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		3pdf DIPEPTIDYL PEPTIDASE
1
(Homo
sapiens)		4 / 7ALA A   4
TYR A  83
TYR A 235
PHE A  80
None
1.16A17.94
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		4jjh POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 4
(Homo
sapiens)		4 / 7ALA A 139
ARG A 140
TYR A 125
TYR A  94
None
1.21A19.28
18.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		4m5y FAB 5J8 HEAVY CHAIN
(Homo
sapiens)		4 / 7ALA H  93
ARG H  94
TYR H 100
TYR H  58
None
1.22A62.07
29.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		4oem DIPEPTIDYL PEPTIDASE
1 HEAVY CHAIN
(Homo
sapiens)		4 / 7ALA A   4
TYR A  83
TYR A 235
PHE A  80
None
1.17A20.21
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		5crv TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 23
(Homo
sapiens)		4 / 7ALA A  55
TYR A  71
ARG A  52
TYR A 119
None
1.16A19.48
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		5dcz TANKYRASE-2
(Homo
sapiens)		4 / 7ALA A1135
ARG A 980
TYR A1050
TYR A1060
None
PO4  A1202 (-4.9A)
59B  A1203 ( 4.3A)
59B  A1203 (-4.3A)
1.20A21.54
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		5la7 HEPARANASE
(Homo
sapiens)		4 / 7ALA A 177
TYR A 174
TYR A  91
TYR A 264
EDO  A 610 ( 4.0A)
EDO  A 610 (-4.2A)
None
None
1.09A19.61
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1
(Homo
sapiens)		4 / 7ALA A1189
TYR A1173
ARG A1190
PHE A1198
None
SAM  A3001 (-4.0A)
None
None
1.18A15.33
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		5zal ENDORIBONUCLEASE
DICER
(Homo
sapiens)		4 / 7ALA A1686
TYR A1692
TYR A  83
PHE A1666
None
1.21A19.34
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		6c01 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 3
(Homo
sapiens)		4 / 7ALA A 341
TYR A 289
TYR A 320
PHE A 295
None
1.16A17.88
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		1by1 PROTEIN (PIX)
(Homo
sapiens)		4 / 6TYR A 103
TYR A 155
GLN A  68
ILE A  64
None
1.46A22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA
(Homo
sapiens)		4 / 6TYR A 106
TRP A  21
TYR A  12
GLN A  31
None
1.36A21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		1kdu PLASMINOGEN
ACTIVATOR
(Homo
sapiens)		4 / 6TYR A  36
TRP A  62
TYR A  64
GLN A  73
None
1.07A19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		2lmd PROSPERO HOMEOBOX
PROTEIN 1
(Homo
sapiens)		4 / 6TYR A  75
TYR A  68
GLN A 123
ILE A  92
None
1.14A21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens)		4 / 6TRP A 250
TYR A 195
GLN A 192
ILE A 191
None
1.42A20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		3n0t DIPEPTIDYL PEPTIDASE
2
(Homo
sapiens)		4 / 6TYR A 110
TRP A 347
TYR A 163
ILE A 355
None
OPY  A1001 (-4.1A)
None
None
1.49A20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		3u73 UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens)		4 / 6TYR A  84
TRP A 112
TYR A 114
GLN A 124
None
1.27A16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		5dag PROTEIN AF-10
(Homo
sapiens)		4 / 6TRP A  66
TYR A  56
GLN A  53
ILE A  58
None
1.49A21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens)		4 / 6TYR B 844
TYR B 846
GLN B 870
ILE B 869
NAG  B1304 ( 4.9A)
None
None
None
1.21A20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1
(Homo
sapiens)		4 / 6TYR A 435
TYR A 407
GLN A 406
ILE A 443
None
1.02A16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		5uj8 ORIGIN RECOGNITION
COMPLEX SUBUNIT 2
(Homo
sapiens)		4 / 6TYR E 294
TRP E 301
TYR E 314
ILE E 311
None
1.42A21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		1fzd FIBRINOGEN-420
(Homo
sapiens)		5 / 11ASP A 711
ALA A 713
ASP A 831
TYR A 832
GLY A 829
None
1.04A16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		1rxt GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 1
(Homo
sapiens)		5 / 11PHE A 111
VAL A 395
ASP A 394
PHE A 234
SER A 334
None
1.07A20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens)		5 / 11ALA A 425
VAL A 105
ASP A 104
TYR A 103
GLY A 261
None
1.28A23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		4lec PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21A
(Homo
sapiens)		5 / 11ASP A  94
ALA A  98
TYR A 147
GLY A  77
GLY A 142
SAH  A 301 (-2.9A)
SAH  A 301 ( 4.0A)
SAH  A 301 (-4.4A)
None
None
1.04A18.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER
(Homo
sapiens)		6 / 11ASP A  98
TYR A 175
TYR A 176
GLY A 338
SER A 438
GLY A 442
None
0.57A53.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens)		5 / 11ASP A 138
ASP A 109
TYR A 108
GLY A 100
GLY A 110
None
1.26A20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		6eoq DIPEPTIDYL PEPTIDASE
9
(Homo
sapiens)		5 / 11PHE A 734
VAL A 643
TYR A 644
GLY A 698
GLY A 733
None
1.15A7.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XPB_A_COCA702_1
(TRANSPORTER)		5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER
(Homo
sapiens)		6 / 10ASP A  98
TYR A 175
TYR A 176
GLY A 338
SER A 438
GLY A 442
None
0.43A53.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XPB_A_COCA702_1
(TRANSPORTER)		5ool 39S RIBOSOMAL
PROTEIN L37,
MITOCHONDRIAL
(Homo
sapiens)		5 / 10PHE 5 354
VAL 5 181
TYR 5 292
PHE 5 352
GLY 5 346
None
1.40A21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XPB_A_COCA702_1
(TRANSPORTER)		6bsz METABOTROPIC
GLUTAMATE RECEPTOR 8
(Homo
sapiens)		5 / 10TYR A 471
GLY A 228
PHE A 281
SER A 310
GLY A 307
None
1.43A11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XPB_A_COCA702_1
(TRANSPORTER)		6c01 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 3
(Homo
sapiens)		5 / 10ASP A 167
TYR A 289
TYR A 320
PHE A 295
SER A 165
 ZN  A 902 (-2.0A)
None
None
None
None
1.41A9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XPB_A_COCA702_1
(TRANSPORTER)		6eoq DIPEPTIDYL PEPTIDASE
9
(Homo
sapiens)		5 / 10PHE A 734
VAL A 643
TYR A 644
GLY A 698
GLY A 733
None
1.15A8.35