POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.


DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)
1kcw CERULOPLASMIN
(Homo
sapiens)
4 / 8TYR A 765
TYR A 861
PHE A 805
ILE A 804
None
1.07A15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)
1ldk CULLIN HOMOLOG
(Homo
sapiens)
4 / 8TYR A  50
TYR A 139
SER A  55
ILE A  15
None
0.95A23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)
1pbw PHOSPHATIDYLINOSITOL
3-KINASE
(Homo
sapiens)
4 / 8GLU A 140
TYR A 150
PHE A 268
ILE A 294
None
1.04A20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)
1pbw PHOSPHATIDYLINOSITOL
3-KINASE
(Homo
sapiens)
4 / 8TYR A 150
GLU A 140
PHE A 268
ILE A 290
None
1.05A20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)
1z7c CHORIONIC
SOMATOMAMMOTROPIN
HORMONE
(Homo
sapiens)
4 / 8TYR A  28
GLU A  33
PHE A  44
SER A  43
None
1.04A22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)
2nll PROTEIN (RETINOIC
ACID RECEPTOR)
(Homo
sapiens)
4 / 8TYR A 192
TYR A 169
PHE A 158
ILE A 137
None
1.02A10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)
2y0n MALE-SPECIFIC LETHAL
3 HOMOLOG
(Homo
sapiens)
4 / 8TYR A 494
GLU A 493
SER A 212
ILE A 209
None
0.95A22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)
2z13 EF-HAND
DOMAIN-CONTAINING
FAMILY MEMBER C2
(Homo
sapiens)
4 / 8GLU A  23
GLU A  25
PHE A 102
ILE A 104
None
0.85A18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)
3fk2 GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens)
4 / 8TYR A1283
GLU A1273
PHE A1400
ILE A1425
None
1.05A23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)
3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens)
4 / 8TYR A1205
TYR A1172
PHE A1214
ILE A1094
None
1.02A15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)
4uyb SEC14-LIKE PROTEIN 3
(Homo
sapiens)
4 / 8TYR A 294
GLU A 293
PHE A 316
ILE A 314
None
1.07A21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)
4y7i MYOTUBULARIN-RELATED
PROTEIN 8
(Homo
sapiens)
4 / 8GLU A 373
TYR A 360
SER A 134
ILE A 130
None
1.04A21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)
5f9s SERINE--PYRUVATE
AMINOTRANSFERASE
(Homo
sapiens)
4 / 8GLU A  87
TYR A 241
SER A 218
ILE A 220
None
1.04A21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)
5jja SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
56 KDA REGULATORY
SUBUNIT GAMMA
ISOFORM
(Homo
sapiens)
4 / 8TYR A 263
TYR A 292
PHE A 211
ILE A 207
TYR  A 263 ( 1.3A)
TYR  A 292 ( 1.3A)
PHE  A 211 ( 1.3A)
ILE  A 207 ( 0.7A)
1.06A22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)
5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens)
4 / 8GLU A 795
TYR A 773
PHE A 767
SER A 800
None
0.86A16.99