POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		1fta FRUCTOSE-1,6-BISPHOS
PHATASE
(Homo
sapiens)		5 / 10VAL A 302
ILE A 316
THR A 255
ILE A 261
VAL A 324
None
1.01A21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		1hjo PROTEIN (HEAT-SHOCK
70KD PROTEIN)
(Homo
sapiens)		5 / 10ILE A 212
ALA A 178
ILE A 197
VAL A 335
VAL A 195
None
0.94A21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		1x9n DNA LIGASE I
(Homo
sapiens)		5 / 10VAL A 349
ILE A 427
ALA A 359
THR A 362
VAL A 379
None
0.94A21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		2ax4 BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 2
(Homo
sapiens)		5 / 10VAL A 226
ILE A  81
ILE A 128
VAL A  55
VAL A 126
None
1.04A16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		3fe1 HEAT SHOCK 70 KDA
PROTEIN 6
(Homo
sapiens)		5 / 10ILE A 214
ALA A 180
ILE A 199
VAL A 337
VAL A 197
None
0.87A21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		3no8 BTB/POZ
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens)		5 / 10ILE A 424
PHE A 406
ILE A 401
VAL A 397
VAL A 459
None
1.07A17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN
(Homo
sapiens)		5 / 10ILE A 212
ALA A 178
ILE A 197
VAL A 335
VAL A 195
None
0.92A20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		4j8f HEAT SHOCK 70 KDA
PROTEIN 1A/1B,
HSC70-INTERACTING
PROTEIN
(Homo
sapiens;
Rattus
norvegicus)		5 / 10ILE A 212
ALA A 178
ILE A 197
VAL A 335
VAL A 195
None
0.93A23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		4kkd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens)		5 / 10ALA A 555
THR A 494
ILE A 467
VAL A 516
VAL A 518
None
1.09A22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens)		5 / 10ILE A 214
ALA A 178
ILE A 199
VAL A 337
VAL A 197
None
0.82A20.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		5wbg CYTOCHROME P450 2B6
(Homo
sapiens)		9 / 10VAL A 104
PHE A 108
PHE A 206
ILE A 209
PHE A 297
ALA A 298
THR A 302
VAL A 367
VAL A 477
None
9ZJ  A 502 (-4.4A)
9ZJ  A 502 (-2.6A)
9ZJ  A 502 ( 4.8A)
9ZJ  A 502 ( 4.5A)
9ZJ  A 502 ( 3.5A)
9ZJ  A 502 ( 3.9A)
9ZJ  A 502 ( 4.2A)
None
0.54A86.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		5wbg CYTOCHROME P450 2B6
(Homo
sapiens)		7 / 10VAL A 104
PHE A 115
PHE A 206
ILE A 209
PHE A 297
ALA A 298
THR A 302
None
9ZJ  A 502 (-4.7A)
9ZJ  A 502 (-2.6A)
9ZJ  A 502 ( 4.8A)
9ZJ  A 502 ( 4.5A)
9ZJ  A 502 ( 3.5A)
9ZJ  A 502 ( 3.9A)
1.46A86.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		2okj GLUTAMATE
DECARBOXYLASE 1
(Homo
sapiens)		4 / 8PHE A 324
ILE A 319
ALA A 360
VAL A 372
None
0.90A23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		2x8a NUCLEAR
VALOSIN-CONTAINING
PROTEIN-LIKE
(Homo
sapiens)		4 / 8ILE A 779
PHE A 832
VAL A 823
VAL A 774
None
0.78A20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		3fe1 HEAT SHOCK 70 KDA
PROTEIN 6
(Homo
sapiens)		4 / 8ILE A 214
ALA A 180
VAL A 337
VAL A 197
None
0.82A21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN
(Homo
sapiens)		4 / 8ILE A 212
ALA A 178
VAL A 335
VAL A 195
None
0.80A20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens)		4 / 8ILE A 214
ALA A 178
VAL A 337
VAL A 197
None
0.71A20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		5vft 26S PROTEASOME
REGULATORY SUBUNIT 8
(Homo
sapiens)		4 / 8ILE C 161
ALA C 204
THR C 207
VAL C 164
None
0.73Aundetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		5wbg CYTOCHROME P450 2B6
(Homo
sapiens)		8 / 8PHE A 108
PHE A 206
ILE A 209
PHE A 297
ALA A 298
THR A 302
VAL A 367
VAL A 477
9ZJ  A 502 (-4.4A)
9ZJ  A 502 (-2.6A)
9ZJ  A 502 ( 4.8A)
9ZJ  A 502 ( 4.5A)
9ZJ  A 502 ( 3.5A)
9ZJ  A 502 ( 3.9A)
9ZJ  A 502 ( 4.2A)
None
0.66A86.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		5wbg CYTOCHROME P450 2B6
(Homo
sapiens)		5 / 8PHE A 115
PHE A 206
ILE A 209
PHE A 297
ALA A 298
9ZJ  A 502 (-4.7A)
9ZJ  A 502 (-2.6A)
9ZJ  A 502 ( 4.8A)
9ZJ  A 502 ( 4.5A)
9ZJ  A 502 ( 3.5A)
1.19A86.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		6gct NEUTRAL AMINO ACID
TRANSPORTER B(0)
(Homo
sapiens)		4 / 8PHE A 400
ALA A 397
VAL A 463
VAL A 459
None
0.89A12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		1lpb LIPASE
(Homo
sapiens)		5 / 9VAL B 104
PHE B  38
ILE B  74
ALA B 126
VAL B  34
None
1.02A21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		2rsv SERINE/THREONINE-PRO
TEIN KINASE VRK1
(Homo
sapiens)		5 / 9VAL A  70
ILE A  29
PHE A  23
ALA A  24
VAL A  62
None
1.25A21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		2zgh GRANZYME M
(Homo
sapiens)		5 / 9VAL A  31
ILE A 224
ALA A  88
VAL A 197
VAL A 217
None
0.89A19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		3t1w FOUR-DOMAIN
FIBRONECTIN FRAGMENT
(Homo
sapiens)		5 / 9VAL A1414
ILE A1407
ALA A1403
VAL A1427
VAL A1429
None
1.25A21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E
(Homo
sapiens)		5 / 9ILE A 187
PHE A 449
ALA A 450
THR A 290
VAL A 282
None
None
HEM  A 601 (-3.5A)
HEM  A 601 (-4.2A)
None
1.19A26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens)		5 / 9VAL A 167
PHE A 236
ALA A 203
THR A 206
VAL A 245
LLP  A  41 ( 4.1A)
None
None
None
None
1.07A21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		4nen INTEGRIN ALPHA-X
(Homo
sapiens)		5 / 9VAL A  32
PHE A  18
PHE A  11
ALA A  56
THR A  54
None
1.05A17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		4qt8 MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens)		5 / 9VAL B 520
ILE B 471
ALA B 462
VAL B 502
VAL B 498
None
1.21A22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		5mr7 GRAINYHEAD-LIKE
PROTEIN 2 HOMOLOG
(Homo
sapiens)		5 / 9VAL A 300
ILE A 278
PHE A 468
THR A 268
VAL A 371
None
1.25A10.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		5wbg CYTOCHROME P450 2B6
(Homo
sapiens)		9 / 9VAL A 104
PHE A 108
PHE A 206
ILE A 209
PHE A 297
ALA A 298
THR A 302
VAL A 367
VAL A 477
None
9ZJ  A 502 (-4.4A)
9ZJ  A 502 (-2.6A)
9ZJ  A 502 ( 4.8A)
9ZJ  A 502 ( 4.5A)
9ZJ  A 502 ( 3.5A)
9ZJ  A 502 ( 3.9A)
9ZJ  A 502 ( 4.2A)
None
0.46A86.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		5wbg CYTOCHROME P450 2B6
(Homo
sapiens)		7 / 9VAL A 104
PHE A 115
PHE A 206
ILE A 209
PHE A 297
ALA A 298
THR A 302
None
9ZJ  A 502 (-4.7A)
9ZJ  A 502 (-2.6A)
9ZJ  A 502 ( 4.8A)
9ZJ  A 502 ( 4.5A)
9ZJ  A 502 ( 3.5A)
9ZJ  A 502 ( 3.9A)
1.42A86.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens)		5 / 9VAL A 145
PHE A 102
PHE A 120
ILE A 123
VAL A 127
None
1.26A12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		1n7j PHENYLETHANOLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens)		5 / 9PHE A 274
ILE A 214
ALA A  62
THR A  64
VAL A 179
None
1.13A20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		2zgh GRANZYME M
(Homo
sapiens)		5 / 9VAL A  31
ILE A 224
ALA A  88
VAL A 197
VAL A 217
None
0.90A19.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		3e4e CYTOCHROME P450 2E1
(Homo
sapiens)		5 / 9PHE A 116
PHE A 207
PHE A 298
ALA A 299
VAL A 364
None
None
None
HEM  A 500 ( 3.3A)
HEM  A 500 ( 4.4A)
1.14A49.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		3op3 M-PHASE INDUCER
PHOSPHATASE 3
(Homo
sapiens)		5 / 9VAL A 327
PHE A 325
ILE A 341
ALA A 312
VAL A 305
None
1.01A18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		3pdy PLECTIN
(Homo
sapiens)		5 / 9PHE A 723
PHE A 648
ALA A 651
THR A 653
VAL A 578
None
1.12A18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		3t1w FOUR-DOMAIN
FIBRONECTIN FRAGMENT
(Homo
sapiens)		5 / 9VAL A1414
ILE A1407
ALA A1403
VAL A1427
VAL A1429
None
1.22A21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		4lsd FIBRONECTIN TYPE III
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens)		5 / 9VAL A 100
PHE A  62
ILE A  64
THR A  84
VAL A  48
None
1.19A11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		4qt8 MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens)		5 / 9VAL B 520
ILE B 471
ALA B 462
VAL B 502
VAL B 498
None
1.26A22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		5eod COAGULATION FACTOR
XI
(Homo
sapiens)		5 / 9VAL A 472
ILE A 402
THR A 410
VAL A 426
VAL A 385
None
1.25A22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		5mr7 GRAINYHEAD-LIKE
PROTEIN 2 HOMOLOG
(Homo
sapiens)		5 / 9VAL A 300
ILE A 278
PHE A 468
THR A 268
VAL A 371
None
1.26A10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		5n47 FIBRONECTIN
(Homo
sapiens)		5 / 9VAL B1414
ILE B1407
ALA B1403
VAL B1427
VAL B1429
None
1.21A10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		5u03 CTP SYNTHASE 1
(Homo
sapiens)		5 / 9VAL A 262
ILE A 242
ALA A  20
VAL A 253
VAL A 244
None
1.20A21.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		5wbg CYTOCHROME P450 2B6
(Homo
sapiens)		9 / 9VAL A 104
PHE A 108
PHE A 206
ILE A 209
PHE A 297
ALA A 298
THR A 302
VAL A 367
VAL A 477
None
9ZJ  A 502 (-4.4A)
9ZJ  A 502 (-2.6A)
9ZJ  A 502 ( 4.8A)
9ZJ  A 502 ( 4.5A)
9ZJ  A 502 ( 3.5A)
9ZJ  A 502 ( 3.9A)
9ZJ  A 502 ( 4.2A)
None
0.62A86.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		5wbg CYTOCHROME P450 2B6
(Homo
sapiens)		7 / 9VAL A 104
PHE A 115
PHE A 206
ILE A 209
PHE A 297
ALA A 298
THR A 302
None
9ZJ  A 502 (-4.7A)
9ZJ  A 502 (-2.6A)
9ZJ  A 502 ( 4.8A)
9ZJ  A 502 ( 4.5A)
9ZJ  A 502 ( 3.5A)
9ZJ  A 502 ( 3.9A)
1.47A86.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens)		5 / 9VAL A 145
PHE A 102
PHE A 120
ILE A 123
VAL A 127
None
1.28A12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		1as4 ANTICHYMOTRYPSIN
(Homo
sapiens)		5 / 11ILE B 374
PHE A 341
ALA A 347
ILE A  51
VAL B 388
ACT  B 600 (-4.6A)
None
ACT  B 600 (-3.6A)
None
None
1.05A7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		1y6l UBIQUITIN-CONJUGATIN
G ENZYME E2E2
(Homo
sapiens)		5 / 11ILE A 106
ILE A  99
ILE A  37
ALA A  23
VAL A  67
None
0.86A15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		2esp UBIQUITIN-CONJUGATIN
G ENZYME E2 D2
(Homo
sapiens)		5 / 11ILE A 106
ILE A  99
ILE A  37
ALA A  23
VAL A  67
None
1.02A14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		3bzh UBIQUITIN-CONJUGATIN
G ENZYME E2 E1
(Homo
sapiens)		5 / 11ILE A 152
ILE A 145
ILE A  83
ALA A  69
VAL A 113
None
None
None
None
GOL  A 200 ( 4.3A)
0.94A15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		3dkp PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX52
(Homo
sapiens)		5 / 11ILE A 149
ILE A 191
PHE A 163
ALA A 218
VAL A 374
None
1.05A17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens)		5 / 11ILE A 506
LEU A 107
ALA A 571
ALA A 574
ILE A 529
None
1.15A21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens)		5 / 11ILE A 216
ILE A 254
ALA A 346
ALA A 345
VAL A 258
None
1.18A21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens)		5 / 11ILE A 406
ILE A 402
ALA A 343
ILE A 439
VAL A 430
None
1.19A21.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		5wbg CYTOCHROME P450 2B6
(Homo
sapiens)		8 / 11ILE A 101
ILE A 114
ILE A 209
LEU A 238
ALA A 298
THR A 302
VAL A 367
VAL A 477
9ZJ  A 502 (-4.5A)
9ZJ  A 502 ( 3.6A)
9ZJ  A 502 ( 4.8A)
None
9ZJ  A 502 ( 3.5A)
9ZJ  A 502 ( 3.9A)
9ZJ  A 502 ( 4.2A)
None
0.73A86.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		6fuy VINCULIN
(Homo
sapiens)		5 / 11ILE A 273
ILE A 302
THR A 324
ILE A 321
VAL A 367
None
1.09A10.00