POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		1ezf FARNESYL-DIPHOSPHATE
FARNESYLTRANSFERASE
(Homo
sapiens)		4 / 7THR A  42
TYR A  46
ASN A  48
LEU A  74
None
1.09A22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		1h2t 80 KDA NUCLEAR CAP
BINDING PROTEIN
(Homo
sapiens)		4 / 7HIS C 276
TYR C 282
ASN C 120
TYR C 121
None
1.04A21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		1hu3 EIF4GII
(Homo
sapiens)		4 / 7HIS A 911
TYR A 952
ASN A 954
LEU A 918
None
1.12A21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		1l1f GLUTAMATE
DEHYDROGENASE 1
(Homo
sapiens)		4 / 7THR A 116
TYR A 117
ASN A 488
LEU A 375
None
1.05A20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		1shc SHC
(Homo
sapiens)		4 / 7THR A  78
ASN A  72
LEU A 106
GLN A  76
None
0.90A17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		1wf5 SIDEKICK 2 PROTEIN
(Homo
sapiens)		4 / 7HIS A  19
THR A  41
TYR A  53
LEU A  93
None
1.07A14.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		1zxn DNA TOPOISOMERASE
II, ALPHA ISOZYME
(Homo
sapiens)		6 / 7HIS A  42
THR A  49
TYR A  50
ASN A 163
TYR A 165
LEU A 169
None
None
None
GOL  A 599 ( 4.7A)
None
None
0.58A50.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		2b3o TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 6
(Homo
sapiens)		4 / 7THR A 487
ASN A 258
LEU A 251
GLN A 489
None
0.96A20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		2ck2 HUMAN FIBRONECTIN
(Homo
sapiens)		4 / 7THR A  58
TYR A  57
TYR A  36
LEU A  34
None
1.06A12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		2p31 GLUTATHIONE
PEROXIDASE 7
(Homo
sapiens)		4 / 7THR A  60
TYR A  64
ASN A  52
LEU A  67
None
1.05A15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		2pqf POLY [ADP-RIBOSE]
POLYMERASE 12
(Homo
sapiens)		4 / 7HIS A 605
THR A 679
TYR A 677
GLN A 527
None
1.07A18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		2rjq ADAMTS-5
(Homo
sapiens)		4 / 7HIS A 289
TYR A 491
LEU A 499
GLN A 495
None
None
None
NAG  A 557 (-3.4A)
1.04A18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		2vpj KELCH-LIKE PROTEIN
12
(Homo
sapiens)		4 / 7HIS A 474
TYR A 476
TYR A 540
LEU A 522
None
1.14A18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		3aad HISTONE CHAPERONE
ASF1A
(Homo
sapiens)		4 / 7TYR B  44
ASN B  80
LEU B  57
GLN B  55
None
0.85A16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens)		4 / 7TYR A4078
ASN A4102
TYR A4106
LEU A4080
None
0.83A19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		3kij PROBABLE GLUTATHIONE
PEROXIDASE 8
(Homo
sapiens)		4 / 7THR A  82
TYR A  86
ASN A  74
LEU A  89
None
1.09A17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		3ouh EGL NINE HOMOLOG 1
(Homo
sapiens)		4 / 7HIS A 230
THR A 382
TYR A 384
LEU A 330
None
1.10A21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		3zyj LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4C
NETRIN-G1
(Homo
sapiens)		4 / 7THR A 128
ASN B  90
LEU A  80
GLN A 106
None
1.10A19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		4irq BETA-1,4-GALACTOSYLT
RANSFERASE 7
(Homo
sapiens)		4 / 7HIS A  83
THR A 308
TYR A 129
LEU A  98
None
1.08A18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens)		4 / 7TYR B4078
ASN B4102
TYR B4106
LEU B4080
None
1.00A21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		5ugw TELOMERASE REVERSE
TRANSCRIPTASE
(Homo
sapiens)		4 / 7HIS A1013
THR A1088
TYR A1089
LEU A1092
None
0.76A15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		1h2t 80 KDA NUCLEAR CAP
BINDING PROTEIN
(Homo
sapiens)		4 / 7HIS C 276
TYR C 282
ASN C 120
TYR C 121
None
0.84A21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		1hu3 EIF4GII
(Homo
sapiens)		4 / 7HIS A 911
TYR A 952
ASN A 954
LEU A 918
None
1.05A21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		1lyb CATHEPSIN D
(Homo
sapiens)		4 / 7THR A  23
ASN A  60
TYR A  59
GLN A  26
None
0.91A14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		1shc SHC
(Homo
sapiens)		4 / 7THR A  78
ASN A  72
LEU A 106
GLN A  76
None
0.89A17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		1wf5 SIDEKICK 2 PROTEIN
(Homo
sapiens)		4 / 7HIS A  19
THR A  41
TYR A  53
LEU A  93
None
1.06A14.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		1zxn DNA TOPOISOMERASE
II, ALPHA ISOZYME
(Homo
sapiens)		6 / 7HIS A  42
THR A  49
TYR A  50
ASN A 163
TYR A 165
LEU A 169
None
None
None
GOL  A 599 ( 4.7A)
None
None
0.55A50.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		2ck2 HUMAN FIBRONECTIN
(Homo
sapiens)		4 / 7THR A  58
TYR A  57
TYR A  36
LEU A  34
None
1.07A12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		2p31 GLUTATHIONE
PEROXIDASE 7
(Homo
sapiens)		4 / 7THR A  60
TYR A  64
ASN A  52
LEU A  67
None
1.06A15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		2pqf POLY [ADP-RIBOSE]
POLYMERASE 12
(Homo
sapiens)		4 / 7HIS A 605
THR A 679
TYR A 677
GLN A 527
None
1.06A18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		2rjq ADAMTS-5
(Homo
sapiens)		4 / 7HIS A 289
TYR A 491
LEU A 499
GLN A 495
None
None
None
NAG  A 557 (-3.4A)
1.04A18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		2vpj KELCH-LIKE PROTEIN
12
(Homo
sapiens)		4 / 7HIS A 474
TYR A 476
TYR A 540
LEU A 522
None
1.11A18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		3aad HISTONE CHAPERONE
ASF1A
(Homo
sapiens)		4 / 7TYR B  44
ASN B  80
LEU B  57
GLN B  55
None
0.93A16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens)		4 / 7TYR A4078
ASN A4102
TYR A4106
LEU A4080
None
0.79A19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		3go1 FAB 268-D, HEAVY
CHAIN
(Homo
sapiens)		4 / 7THR H  54
TYR H  52
ASN H  58
TYR H  33
None
None
SO4  H 214 (-4.4A)
None
1.12A20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		3kij PROBABLE GLUTATHIONE
PEROXIDASE 8
(Homo
sapiens)		4 / 7THR A  82
TYR A  86
ASN A  74
LEU A  89
None
1.10A17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		3ouh EGL NINE HOMOLOG 1
(Homo
sapiens)		4 / 7HIS A 230
THR A 382
TYR A 384
LEU A 330
None
1.09A21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		3zyj LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4C
NETRIN-G1
(Homo
sapiens)		4 / 7THR A 128
ASN B  90
LEU A  80
GLN A 106
None
1.02A19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		4irq BETA-1,4-GALACTOSYLT
RANSFERASE 7
(Homo
sapiens)		4 / 7HIS A  83
THR A 308
TYR A 129
LEU A  98
None
1.07A18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		5m23 WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens)		4 / 7ASN A  34
TYR A  35
LEU A 297
GLN A 295
None
1.09A23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		5ugw TELOMERASE REVERSE
TRANSCRIPTASE
(Homo
sapiens)		4 / 7HIS A1013
THR A1088
TYR A1089
LEU A1092
None
0.78A15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		6byn WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens)		4 / 7ASN W  34
TYR W  35
LEU W 297
GLN W 295
None
1.10A13.46