POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BQT_C_C5EC301_0 (SOLUBLE ACETYLCHOLINE RECEPTOR)	1wf1	RNA-BINDING PROTEIN RALY (Homo sapiens)	4 / 8	TYR A  69 VAL A  79 TYR A  52 ILE A  32	None	1.08A	16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BQT_C_C5EC301_0 (SOLUBLE ACETYLCHOLINE RECEPTOR)	2vfk	AKAP18 DELTA (Homo sapiens)	4 / 8	TYR A 280 CYH A 268 CYH A 282 TYR A 279	None	1.17A	17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BQT_C_C5EC301_0 (SOLUBLE ACETYLCHOLINE RECEPTOR)	2w5z	HISTONE-LYSINE N-METHYLTRANSFERASE HRX (Homo sapiens)	4 / 8	VAL A3927 TYR A3942 CYH A3913 ILE A3856	None	1.33A	20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BQT_C_C5EC301_0 (SOLUBLE ACETYLCHOLINE RECEPTOR)	3bg9	PYRUVATE CARBOXYLASE, MITOCHONDRIAL (Homo sapiens)	4 / 8	TYR A 654 VAL A 649 TYR A 651 TYR A1013	None	1.26A	17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BQT_C_C5EC301_0 (SOLUBLE ACETYLCHOLINE RECEPTOR)	3fe2	PROBABLE ATP-DEPENDENT RNA HELICASE DDX5 (Homo sapiens)	4 / 8	VAL A 183 TYR A 190 CYH A 191 ILE A 220	None	1.33A	20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BQT_C_C5EC301_0 (SOLUBLE ACETYLCHOLINE RECEPTOR)	3ihy	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3 (Homo sapiens)	4 / 8	TYR A 858 TYR A 737 CYH A 733 ILE A 863	None	1.25A	16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BQT_C_C5EC301_0 (SOLUBLE ACETYLCHOLINE RECEPTOR)	3j4r	A-KINASE ANCHOR PROTEIN 18 (Homo sapiens)	4 / 8	TYR A 280 CYH A 268 CYH A 282 TYR A 279	None	1.24A	19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BQT_C_C5EC301_0 (SOLUBLE ACETYLCHOLINE RECEPTOR)	3v70	GTPASE IMAP FAMILY MEMBER 1 (Homo sapiens)	4 / 8	VAL A 135 TYR A 105 CYH A 104 ILE A  86	None	1.26A	20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BQT_C_C5EC301_0 (SOLUBLE ACETYLCHOLINE RECEPTOR)	4d10	COP9 SIGNALOSOME COMPLEX SUBUNIT 3 (Homo sapiens)	4 / 8	TYR C 176 CYH C 146 TYR C 184 ILE C 128	None	1.32A	19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BQT_C_C5EC301_0 (SOLUBLE ACETYLCHOLINE RECEPTOR)	4wwr	LARGE PROLINE-RICH PROTEIN BAG6 UBIQUITIN-LIKE PROTEIN 4A (Homo sapiens; Homo sapiens)	4 / 8	TYR B 123 TRP B  96 TYR A1092 ILE B  99	None	1.22A	16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BQT_C_C5EC301_0 (SOLUBLE ACETYLCHOLINE RECEPTOR)	4ykn	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATIDYLIN OSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM FUSION PROTEIN (Homo sapiens)	4 / 8	VAL A1923 TYR A1904 CYH A1901 ILE A1921	None	1.22A	10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BQT_C_C5EC301_0 (SOLUBLE ACETYLCHOLINE RECEPTOR)	4zwj	CHIMERA PROTEIN OF HUMAN RHODOPSIN, MOUSE S-ARRESTIN, AND T4 ENDOLYSIN (Homo sapiens; Mus musculus; Escherichia virus T4)	4 / 8	VAL A 130 TYR A 223 CYH A 222 ILE A 218	None	1.31A	13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BQT_C_C5EC301_0 (SOLUBLE ACETYLCHOLINE RECEPTOR)	5f6l	HISTONE-LYSINE N-METHYLTRANSFERASE 2A (Homo sapiens)	4 / 8	VAL A3927 TYR A3942 CYH A3913 ILE A3856	None	1.16A	23.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4BQT_C_C5EC301_0 (SOLUBLE ACETYLCHOLINE RECEPTOR)	5fjv	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-2 (Homo sapiens)	4 / 8	TYR A 122 TRP A 178 TYR A 219 TYR A 226	EPJ  A 300 (-4.6A) EPJ  A 300 (-3.7A) EPJ  A 300 (-3.7A) EPJ  A 300 (-3.7A)	0.58A	31.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BQT_C_C5EC301_0 (SOLUBLE ACETYLCHOLINE RECEPTOR)	5gl7	METHIONINE--TRNA LIGASE, CYTOPLASMIC (Homo sapiens)	4 / 8	TYR A 759 VAL A 699 TYR A 692 TYR A 297	None	1.31A	17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BQT_C_C5EC301_0 (SOLUBLE ACETYLCHOLINE RECEPTOR)	5jj2	A-KINASE ANCHOR PROTEIN 7 ISOFORM GAMMA (Homo sapiens)	4 / 8	TYR A 275 CYH A 263 CYH A 277 TYR A 274	MLI  A 303 ( 4.5A) None None None	1.21A	17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BQT_C_C5EC301_0 (SOLUBLE ACETYLCHOLINE RECEPTOR)	5kxi	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4 (Homo sapiens)	4 / 8	TYR A 100 TRP A 156 TYR A 197 TYR A 204	NCT  A 402 (-4.8A) NCT  A 402 (-3.9A) NCT  A 402 ( 4.9A) NCT  A 402 (-3.8A)	0.66A	19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BQT_C_C5EC301_0 (SOLUBLE ACETYLCHOLINE RECEPTOR)	5kyu	PROTEIN TRANSPORT PROTEIN SEC24D (Homo sapiens)	4 / 8	TYR B 370 VAL B 750 TYR B 431 ILE B 691	None	1.26A	14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BQT_C_C5EC301_0 (SOLUBLE ACETYLCHOLINE RECEPTOR)	5t00	TRANSCRIPTIONAL REPRESSOR CTCF (Homo sapiens)	4 / 8	TYR A 358 CYH A 353 CYH A 356 ILE A 370	None ZN  A 502 (-2.2A) ZN  A 502 (-2.3A) None	1.23A	19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BQT_C_C5EC301_0 (SOLUBLE ACETYLCHOLINE RECEPTOR)	5uhp	O-GLCNACASE TIM-BARREL DOMAIN (Homo sapiens)	4 / 8	TYR A 374 CYH A  62 TYR A 296 ILE A 304	None	1.30A	17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BQT_C_C5EC301_0 (SOLUBLE ACETYLCHOLINE RECEPTOR)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	4 / 8	VAL A 923 TYR A 904 CYH A 901 ILE A 921	None	1.11A	undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5SYO_C_C5EC301_0 (SOLUBLE ACETYLCHOLINE RECEPTOR, NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3 CHIMERA)	4f92	U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 200 KDA HELICASE (Homo sapiens)	5 / 10	TRP B1393 MET B1367 ILE B1364 TYR B1378 CYH B1376	None	1.11A	8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5SYO_E_C5EE301_0 (SOLUBLE ACETYLCHOLINE RECEPTOR, NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-3 CHIMERA)	4f92	U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 200 KDA HELICASE (Homo sapiens)	5 / 10	TRP B1393 MET B1367 ILE B1364 TYR B1378 CYH B1376	None	1.08A	8.40