POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		1as4 ANTICHYMOTRYPSIN
(Homo
sapiens)		5 / 12LEU A  64
LEU A  73
ILE A 308
GLY A  79
LEU A  80
None
0.91A24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		1ey2 HOMOGENTISATE
1,2-DIOXYGENASE
(Homo
sapiens)		5 / 12LEU A 301
THR A 302
LEU A 131
LEU A 201
ILE A 317
None
1.00A20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		1luj CATENIN BETA-1
(Homo
sapiens)		5 / 12THR A 297
LEU A 324
ILE A 315
GLY A 320
LEU A 286
None
0.97A20.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		1pcg ESTROGEN RECEPTOR
(Homo
sapiens)		6 / 12MET A 343
LEU A 346
LEU A 402
ILE A 424
GLY A 521
HIS A 524
EST  A   1 ( 4.0A)
EST  A   1 (-4.4A)
None
EST  A   1 ( 4.5A)
EST  A   1 ( 4.1A)
EST  A   1 (-3.8A)
1.47A98.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		1pcg ESTROGEN RECEPTOR
(Homo
sapiens)		12 / 12MET A 343
LEU A 346
THR A 347
LEU A 354
LEU A 384
LEU A 387
MET A 388
LEU A 391
ILE A 424
GLY A 521
HIS A 524
LEU A 525
EST  A   1 ( 4.0A)
EST  A   1 (-4.4A)
None
None
None
EST  A   1 (-4.0A)
None
EST  A   1 ( 3.9A)
EST  A   1 ( 4.5A)
EST  A   1 ( 4.1A)
EST  A   1 (-3.8A)
EST  A   1 (-3.6A)
0.74A98.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		2h5g DELTA
1-PYRROLINE-5-CARBOX
YLATE SYNTHETASE
(Homo
sapiens)		5 / 12LEU A 487
LEU A 433
LEU A 392
ILE A 515
LEU A 428
None
1.04A21.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		2ocf ESTROGEN RECEPTOR
(Homo
sapiens)		6 / 12MET A 343
LEU A 346
LEU A 402
ILE A 424
GLY A 521
HIS A 524
EST  A 596 (-4.8A)
EST  A 596 (-4.4A)
None
EST  A 596 ( 4.7A)
EST  A 596 ( 4.0A)
EST  A 596 (-4.2A)
1.44A99.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		2ocf ESTROGEN RECEPTOR
(Homo
sapiens)		10 / 12MET A 343
LEU A 346
THR A 347
LEU A 354
LEU A 384
LEU A 387
MET A 388
LEU A 391
ILE A 424
GLY A 521
EST  A 596 (-4.8A)
EST  A 596 (-4.4A)
None
None
None
EST  A 596 ( 4.2A)
None
EST  A 596 ( 4.6A)
EST  A 596 ( 4.7A)
EST  A 596 ( 4.0A)
0.64A99.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		2ocf ESTROGEN RECEPTOR
(Homo
sapiens)		10 / 12MET A 343
LEU A 346
THR A 347
LEU A 384
LEU A 387
MET A 388
LEU A 391
GLY A 521
HIS A 524
LEU A 525
EST  A 596 (-4.8A)
EST  A 596 (-4.4A)
None
None
EST  A 596 ( 4.2A)
None
EST  A 596 ( 4.6A)
EST  A 596 ( 4.0A)
EST  A 596 (-4.2A)
EST  A 596 (-3.6A)
0.74A99.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		2ocf ESTROGEN RECEPTOR
(Homo
sapiens)		10 / 12MET A 343
LEU A 346
THR A 347
LEU A 384
LEU A 387
MET A 388
LEU A 391
ILE A 424
GLY A 521
HIS A 524
EST  A 596 (-4.8A)
EST  A 596 (-4.4A)
None
None
EST  A 596 ( 4.2A)
None
EST  A 596 ( 4.6A)
EST  A 596 ( 4.7A)
EST  A 596 ( 4.0A)
EST  A 596 (-4.2A)
0.58A99.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens)		5 / 12LEU A 256
LEU A 422
LEU A 411
ILE A 227
LEU A 426
None
1.05A17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		2z63 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens)		5 / 12MET A 527
LEU A 495
LEU A 519
ILE A 539
LEU A 488
None
1.07A19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		2z6h CATENIN BETA-1
(Homo
sapiens)		5 / 12THR A 297
LEU A 324
ILE A 315
GLY A 320
LEU A 286
None
0.94A18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		3b13 DEDICATOR OF
CYTOKINESIS PROTEIN
2
(Homo
sapiens)		5 / 12LEU A1244
LEU A1479
LEU A1208
LEU A1227
ILE A1221
None
0.92A19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		3h68 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Homo
sapiens)		5 / 12THR A 306
LEU A 340
LEU A 220
HIS A 352
LEU A 385
None
None
None
ZN  A 500 ( 3.2A)
None
1.07A21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		3hhc INTERLEUKIN-28B
(Homo
sapiens)		5 / 12LEU A  69
LEU A 125
LEU A  61
ILE A  96
LEU A 148
None
1.06A20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		3hr0 COG4
(Homo
sapiens)		5 / 12LEU A 675
LEU A 678
MET A 679
LEU A 682
LEU A 545
None
0.72A23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		3i3t UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 21
(Homo
sapiens)		5 / 12LEU A 507
LEU A 459
LEU A 416
LEU A 484
LEU A 463
None
0.95A22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		3iu1 GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 1
(Homo
sapiens)		5 / 12LEU A 176
LEU A 161
LEU A 201
GLY A 213
LEU A 222
None
1.06A19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		3k6g TELOMERIC
REPEAT-BINDING
FACTOR 2-INTERACTING
PROTEIN 1
TELOMERIC
REPEAT-BINDING
FACTOR 2
(Homo
sapiens;
Homo
sapiens)		5 / 12LEU A 343
LEU A 321
MET A 322
LEU A 327
LEU D 288
None
1.07A18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens)		5 / 12LEU A1512
LEU A1503
LEU A1541
LEU A1539
ILE A1529
None
0.88A19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens)		5 / 12THR A  61
LEU A  34
LEU A  71
GLY A  65
HIS A  64
None
None
None
None
ZN  A1364 ( 3.2A)
1.07A22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens)		5 / 12MET A 793
LEU A 750
LEU A 756
LEU A 660
ILE A 817
None
0.90A21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		4ylq COAGULATION FACTOR
VII
(Homo
sapiens)		5 / 12LEU H  46
THR H  45
LEU H 105
LEU H 106
LEU H 108
None
0.98A19.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		1pcg ESTROGEN RECEPTOR
(Homo
sapiens)		4 / 6ALA A 350
GLU A 353
TRP A 383
ARG A 394
EST  A   1 ( 3.7A)
EST  A   1 (-2.8A)
None
EST  A   1 (-3.7A)
0.21A98.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		1pcg ESTROGEN RECEPTOR
(Homo
sapiens)		4 / 6ALA A 350
GLU A 353
TRP A 383
MET A 421
EST  A   1 ( 3.7A)
EST  A   1 (-2.8A)
None
EST  A   1 ( 4.3A)
0.73A98.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		1xb7 STEROID HORMONE
RECEPTOR ERR1
(Homo
sapiens)		4 / 6ASP A 329
GLU A 331
TRP A 361
ARG A 372
None
1.07A33.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		1ya0 SMG-7 TRANSCRIPT
VARIANT 2
(Homo
sapiens)		4 / 6ALA A 381
ASP A 384
GLU A 380
ARG A 309
None
1.43A18.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		2gpv ESTROGEN-RELATED
RECEPTOR GAMMA
(Homo
sapiens)		5 / 6ALA A 272
ASP A 273
GLU A 275
TRP A 305
ARG A 316
OHT  A 500 (-3.5A)
OHT  A 500 (-3.1A)
OHT  A 500 (-2.6A)
None
OHT  A 500 (-3.8A)
0.51A36.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		2iuw ALKYLATED REPAIR
PROTEIN ALKB HOMOLOG
3
(Homo
sapiens)		4 / 6ALA A 102
ASP A 103
GLU A 101
ARG A 164
None
1.38A23.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		2ocf ESTROGEN RECEPTOR
(Homo
sapiens)		5 / 6ALA A 350
GLU A 353
TRP A 383
ARG A 394
MET A 421
EST  A 596 ( 3.9A)
EST  A 596 (-2.7A)
None
EST  A 596 (-4.0A)
EST  A 596 (-4.5A)
0.79A99.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		2r05 PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN
(Homo
sapiens)		4 / 6ALA A 463
ASP A 467
GLU A 462
ARG A 489
None
1.11A17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		3htu VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 25
(Homo
sapiens)		4 / 6ALA A 147
ASP A 145
GLU A 146
ARG A 171
None
1.21A14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		4awn DEOXYRIBONUCLEASE-1
(Homo
sapiens)		4 / 6ALA A 142
ASP A 145
GLU A 143
ARG A  73
None
1.40A22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1
(Homo
sapiens)		4 / 6ALA A 424
ASP A 421
GLU A 425
ARG A 432
None
1.45A16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		4pd3 NONMUSCLE MYOSIN
HEAVY CHAIN B,
ALPHA-ACTININ A
CHIMERA PROTEIN
(Homo
sapiens;
Dictyostelium
discoideum)		4 / 6ALA A 423
ASP A 597
GLU A 422
ARG A 308
None
1.40A14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		4qei GLYCINE--TRNA LIGASE
(Homo
sapiens)		4 / 6ALA A 605
ASP A 608
GLU A 609
ARG A  76
 A  C  37 ( 3.6A)
None
A  C  37 ( 3.4A)
A  C  37 ( 4.5A)
1.25A16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens)		4 / 6ALA A 533
ASP A 534
GLU A 536
ARG A 611
None
1.38A15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		5f4y PROTEIN SHROOM2
(Homo
sapiens)		4 / 6ALA A1572
ASP A1573
GLU A1575
ARG A1556
None
1.22A22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		5ig3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA
(Homo
sapiens)		4 / 6ALA A 360
ASP A 365
ARG A 433
MET A 377
None
1.16A20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		5n7f MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 1,ANNEXIN A2
(Homo
sapiens)		4 / 6ALA A 574
ASP A 577
GLU A 575
ARG A 616
None
1.31A19.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		5toa ESTROGEN RECEPTOR
BETA
(Homo
sapiens)		4 / 6ALA A 302
GLU A 305
TRP A 335
ARG A 346
EST  A 601 ( 3.9A)
EST  A 601 (-2.4A)
None
EST  A 601 (-4.1A)
0.38A57.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		5txf PHOSPHATIDYLCHOLINE-
STEROL
ACYLTRANSFERASE
(Homo
sapiens)		4 / 6ALA A 283
ASP A 284
GLU A 288
ARG A  85
None
1.46A22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		6b4w DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens)		4 / 6ALA A 694
ASP A 697
GLU A 693
ARG A 779
None
1.25A18.47