POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		1wh8 HOMEOBOX PROTEIN
CUX-2
(Homo
sapiens)		4 / 8ILE A  32
VAL A  96
ASN A  95
LEU A  66
None
0.92A19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		2mfq FIBROBLAST GROWTH
FACTOR RECEPTOR
SUBSTRATE 2
(Homo
sapiens)		4 / 8ILE A 104
VAL A  23
MET A 100
LEU A  62
None
0.84A20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		4 / 8ILE A 279
ASN A 351
GLY A 280
LEU A 250
None
0.92A12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		4 / 8ILE A 546
ASN A 511
ASN A 509
GLY A 545
None
0.93A12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5
(Homo
sapiens)		4 / 8ILE A  37
VAL A 191
GLY A 145
LEU A 437
None
0.95A15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		3nnh CUGBP ELAV-LIKE
FAMILY MEMBER 1
(Homo
sapiens)		4 / 8ILE A  92
VAL A  42
MET A  94
GLY A  21
None
None
None
G  E   4 ( 3.4A)
0.90A24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		3o47 ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1,
ADP-RIBOSYLATION
FACTOR 1
(Homo
sapiens)		4 / 8ILE A 150
ASN A 190
MET A 148
LEU A 169
None
0.93A19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens)		4 / 8ILE A  64
ASN A 130
GLY A 159
LEU A 252
None
0.85A15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens)		4 / 8VAL B 365
ASN B 414
ASN B 467
LEU B 437
None
0.54A12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		5ffo INTEGRIN BETA-6
(Homo
sapiens)		4 / 8ILE B 196
MET B 122
ASN B 212
LEU B 124
None
0.99A21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_B_BZMB600_0
(ODORANT-BINDING
PROTEIN)		2mou STAR-RELATED LIPID
TRANSFER PROTEIN 6
(Homo
sapiens)		5 / 9ILE A 144
VAL A 171
ASN A 148
GLY A 177
LEU A 179
None
1.27A23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_B_BZMB600_0
(ODORANT-BINDING
PROTEIN)		3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE
(Homo
sapiens)		5 / 9ILE A 260
MET A 239
ASN A 253
GLY A 258
LEU A 268
None
1.41A15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		1fsu N-ACETYLGALACTOSAMIN
E-4-SULFATASE
(Homo
sapiens)		5 / 12ILE A 350
GLY A 101
ASP A 372
GLY A 373
TYR A 103
None
1.25A18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		1uou THYMIDINE
PHOSPHORYLASE
(Homo
sapiens)		5 / 12LEU A 127
GLY A 152
ASP A 156
GLY A 145
HIS A 283
None
1.19A20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		1w6j LANOSTEROL SYNTHASE
(Homo
sapiens)		5 / 12ILE A 338
TRP A 230
GLY A 336
GLY A 380
HIS A 232
R71  A1733 (-4.8A)
None
None
R71  A1733 (-4.3A)
R71  A1733 (-3.5A)
1.15A16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		1wsv AMINOMETHYLTRANSFERA
SE
(Homo
sapiens)		5 / 12ILE A 308
LEU A 348
VAL A 319
GLY A 335
GLY A 294
ILE  A 308 ( 0.7A)
LEU  A 348 ( 0.6A)
VAL  A 319 ( 0.6A)
GLY  A 335 ( 0.0A)
GLY  A 294 ( 0.0A)
1.05A20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		2fy1 RNA-BINDING MOTIF
PROTEIN, Y
CHROMOSOME, FAMILY 1
MEMBER A1
(Homo
sapiens)		5 / 12ILE A  12
LEU A  24
GLY A  14
GLY A  49
HIS A  74
None
None
C  B 119 ( 2.7A)
C  B 119 ( 4.8A)
None
1.12A19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens)		5 / 12ILE A 164
LEU A 180
SER A 185
GLY A 186
HIS A 155
None
1.24A21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		3qve HMG BOX-CONTAINING
PROTEIN 1
(Homo
sapiens)		6 / 12TRP A 212
VAL A 333
GLY A 261
GLY A 285
TYR A 257
HIS A 213
None
EDO  A  13 ( 4.6A)
EDO  A  13 (-4.4A)
EDO  A  13 (-3.6A)
None
None
1.25A17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens)		6 / 12ILE A 600
LEU A 595
VAL A 601
GLY A 696
ASP A 697
HIS A 677
0F4  A 902 (-4.1A)
0F4  A 902 ( 4.8A)
None
0F4  A 902 (-3.3A)
None
0F4  A 902 (-4.1A)
1.24A20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens)		5 / 12ILE A 205
LEU A 152
TRP A 374
GLY A 203
GLY A 149
None
None
None
CL  A 407 ( 4.4A)
None
1.19A20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		4igm 2-AMINO-3-CARBOXYMUC
ONATE-6-SEMIALDEHYDE
DECARBOXYLASE
(Homo
sapiens)		5 / 12HIS A   8
VAL A 173
ASP A 265
GLY A 226
HIS A   6
 ZN  A 401 (-3.5A)
None
None
None
ZN  A 401 (-3.4A)
1.21A20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
8
(Homo
sapiens)		5 / 12ILE B  88
LEU B  91
SER B 106
GLY B 110
GLY B 105
None
1.08A15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens)		5 / 12ILE A 657
LEU A 651
VAL A 658
ASP A 836
HIS A 816
748  A1001 ( 4.4A)
None
748  A1001 ( 4.8A)
748  A1001 (-4.8A)
748  A1001 (-3.8A)
1.22A19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		5ifm NON-POU
DOMAIN-CONTAINING
OCTAMER-BINDING
PROTEIN
(Homo
sapiens)		5 / 12LEU A 215
SER A 188
VAL A 179
GLY A 191
GLY A 189
None
1.16A18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		5jk7 URACIL-DNA
GLYCOSYLASE
(Homo
sapiens)		5 / 12ILE D 299
LEU D 291
VAL D 200
GLY D 199
ASP D 136
None
1.25A22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens)		5 / 12ILE A 378
HIS A 100
GLY A 398
GLY A 396
HIS A 403
None
None
FAD  A 901 (-4.4A)
None
None
1.03A14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens)		5 / 12LEU A 232
SER A 104
VAL A 106
GLY A  99
GLY A 101
None
SO4  A 702 (-2.7A)
W4A  A 716 ( 4.7A)
W4A  A 716 ( 4.0A)
SO4  A 702 (-3.3A)
1.24A20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens)		5 / 12ILE A 247
LEU A 242
GLY A 329
ASP A 330
HIS A 310
FKY  A9001 (-4.1A)
FKY  A9001 (-4.7A)
FKY  A9001 (-3.4A)
None
FKY  A9001 (-3.9A)
0.94Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		1g82 FIBROBLAST GROWTH
FACTOR 9
(Homo
sapiens)		5 / 12ILE A  82
LEU A  74
SER A 112
GLY A 126
GLY A 109
None
0.95A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		1w6j LANOSTEROL SYNTHASE
(Homo
sapiens)		5 / 12ILE A 338
TRP A 230
GLY A 336
GLY A 380
HIS A 232
R71  A1733 (-4.8A)
None
None
R71  A1733 (-4.3A)
R71  A1733 (-3.5A)
1.14A16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		1wsv AMINOMETHYLTRANSFERA
SE
(Homo
sapiens)		5 / 12ILE A 308
LEU A 348
VAL A 319
GLY A 335
GLY A 294
ILE  A 308 ( 0.7A)
LEU  A 348 ( 0.6A)
VAL  A 319 ( 0.6A)
GLY  A 335 ( 0.0A)
GLY  A 294 ( 0.0A)
1.01A20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		2fy1 RNA-BINDING MOTIF
PROTEIN, Y
CHROMOSOME, FAMILY 1
MEMBER A1
(Homo
sapiens)		5 / 12ILE A  12
LEU A  24
GLY A  14
GLY A  49
HIS A  74
None
None
C  B 119 ( 2.7A)
C  B 119 ( 4.8A)
None
1.13A19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens)		5 / 12ILE A 164
LEU A 180
SER A 185
GLY A 186
HIS A 155
None
1.23A21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		3qve HMG BOX-CONTAINING
PROTEIN 1
(Homo
sapiens)		6 / 12TRP A 212
VAL A 333
GLY A 261
GLY A 285
TYR A 257
HIS A 213
None
EDO  A  13 ( 4.6A)
EDO  A  13 (-4.4A)
EDO  A  13 (-3.6A)
None
None
1.24A17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens)		6 / 12ILE A 600
LEU A 595
VAL A 601
GLY A 696
ASP A 697
HIS A 677
0F4  A 902 (-4.1A)
0F4  A 902 ( 4.8A)
None
0F4  A 902 (-3.3A)
None
0F4  A 902 (-4.1A)
1.24A20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens)		5 / 12ILE A 205
LEU A 152
TRP A 374
GLY A 203
GLY A 149
None
None
None
CL  A 407 ( 4.4A)
None
1.21A20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		4igm 2-AMINO-3-CARBOXYMUC
ONATE-6-SEMIALDEHYDE
DECARBOXYLASE
(Homo
sapiens)		5 / 12HIS A   8
VAL A 173
ASP A 265
GLY A 226
HIS A   6
 ZN  A 401 (-3.5A)
None
None
None
ZN  A 401 (-3.4A)
1.21A20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens)		5 / 12ILE A 657
LEU A 651
VAL A 658
ASP A 836
HIS A 816
748  A1001 ( 4.4A)
None
748  A1001 ( 4.8A)
748  A1001 (-4.8A)
748  A1001 (-3.8A)
1.24A19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens)		5 / 12ILE A 378
HIS A 100
GLY A 398
GLY A 396
HIS A 403
None
None
FAD  A 901 (-4.4A)
None
None
1.00A14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens)		5 / 12ILE A 247
LEU A 242
GLY A 329
ASP A 330
HIS A 310
FKY  A9001 (-4.1A)
FKY  A9001 (-4.7A)
FKY  A9001 (-3.4A)
None
FKY  A9001 (-3.9A)
0.94Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		1w6j LANOSTEROL SYNTHASE
(Homo
sapiens)		5 / 12ILE A 338
TRP A 230
GLY A 336
GLY A 380
HIS A 232
R71  A1733 (-4.8A)
None
None
R71  A1733 (-4.3A)
R71  A1733 (-3.5A)
1.14A16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		1wsv AMINOMETHYLTRANSFERA
SE
(Homo
sapiens)		5 / 12ILE A 308
LEU A 348
VAL A 319
GLY A 335
GLY A 294
ILE  A 308 ( 0.7A)
LEU  A 348 ( 0.6A)
VAL  A 319 ( 0.6A)
GLY  A 335 ( 0.0A)
GLY  A 294 ( 0.0A)
1.04A20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		2fy1 RNA-BINDING MOTIF
PROTEIN, Y
CHROMOSOME, FAMILY 1
MEMBER A1
(Homo
sapiens)		5 / 12ILE A  12
LEU A  24
GLY A  14
GLY A  49
HIS A  74
None
None
C  B 119 ( 2.7A)
C  B 119 ( 4.8A)
None
1.14A19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		3qve HMG BOX-CONTAINING
PROTEIN 1
(Homo
sapiens)		6 / 12TRP A 212
VAL A 333
GLY A 261
GLY A 285
TYR A 257
HIS A 213
None
EDO  A  13 ( 4.6A)
EDO  A  13 (-4.4A)
EDO  A  13 (-3.6A)
None
None
1.25A17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens)		6 / 12ILE A 600
LEU A 595
VAL A 601
GLY A 696
ASP A 697
HIS A 677
0F4  A 902 (-4.1A)
0F4  A 902 ( 4.8A)
None
0F4  A 902 (-3.3A)
None
0F4  A 902 (-4.1A)
1.24A20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		4igm 2-AMINO-3-CARBOXYMUC
ONATE-6-SEMIALDEHYDE
DECARBOXYLASE
(Homo
sapiens)		5 / 12HIS A   8
VAL A 173
ASP A 265
GLY A 226
HIS A   6
 ZN  A 401 (-3.5A)
None
None
None
ZN  A 401 (-3.4A)
1.21A20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
8
(Homo
sapiens)		5 / 12ILE B  88
LEU B  91
SER B 106
GLY B 110
GLY B 105
None
1.12A15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens)		5 / 12ILE A 378
HIS A 100
GLY A 398
GLY A 396
HIS A 403
None
None
FAD  A 901 (-4.4A)
None
None
1.02A14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens)		5 / 12ILE A 247
LEU A 242
GLY A 329
ASP A 330
HIS A 310
FKY  A9001 (-4.1A)
FKY  A9001 (-4.7A)
FKY  A9001 (-3.4A)
None
FKY  A9001 (-3.9A)
0.94Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		1fsu N-ACETYLGALACTOSAMIN
E-4-SULFATASE
(Homo
sapiens)		5 / 12ILE A 350
GLY A 101
ASP A 372
GLY A 373
TYR A 103
None
1.23A18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		1uou THYMIDINE
PHOSPHORYLASE
(Homo
sapiens)		5 / 12LEU A 127
GLY A 152
ASP A 156
GLY A 145
HIS A 283
None
1.17A20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		1w6j LANOSTEROL SYNTHASE
(Homo
sapiens)		5 / 12ILE A 338
TRP A 230
GLY A 336
GLY A 380
HIS A 232
R71  A1733 (-4.8A)
None
None
R71  A1733 (-4.3A)
R71  A1733 (-3.5A)
1.15A16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		1wsv AMINOMETHYLTRANSFERA
SE
(Homo
sapiens)		5 / 12ILE A 308
LEU A 348
VAL A 319
GLY A 335
GLY A 294
ILE  A 308 ( 0.7A)
LEU  A 348 ( 0.6A)
VAL  A 319 ( 0.6A)
GLY  A 335 ( 0.0A)
GLY  A 294 ( 0.0A)
1.04A20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		2fy1 RNA-BINDING MOTIF
PROTEIN, Y
CHROMOSOME, FAMILY 1
MEMBER A1
(Homo
sapiens)		5 / 12ILE A  12
LEU A  24
GLY A  14
GLY A  49
HIS A  74
None
None
C  B 119 ( 2.7A)
C  B 119 ( 4.8A)
None
1.12A19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		3qve HMG BOX-CONTAINING
PROTEIN 1
(Homo
sapiens)		6 / 12TRP A 212
VAL A 333
GLY A 261
GLY A 285
TYR A 257
HIS A 213
None
EDO  A  13 ( 4.6A)
EDO  A  13 (-4.4A)
EDO  A  13 (-3.6A)
None
None
1.26A17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens)		5 / 12ILE A 600
VAL A 601
GLY A 696
ASP A 697
HIS A 677
0F4  A 902 (-4.1A)
None
0F4  A 902 (-3.3A)
None
0F4  A 902 (-4.1A)
1.22A20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens)		5 / 12ILE A 205
LEU A 152
TRP A 374
GLY A 203
GLY A 149
None
None
None
CL  A 407 ( 4.4A)
None
1.18A20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		4igm 2-AMINO-3-CARBOXYMUC
ONATE-6-SEMIALDEHYDE
DECARBOXYLASE
(Homo
sapiens)		5 / 12HIS A   8
VAL A 173
ASP A 265
GLY A 226
HIS A   6
 ZN  A 401 (-3.5A)
None
None
None
ZN  A 401 (-3.4A)
1.20A20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		4yj5 PYRUVATE KINASE PKM
(Homo
sapiens)		5 / 12LEU A 203
VAL A 209
GLY A 208
ASP A 178
GLY A 179
None
1.19A20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
8
(Homo
sapiens)		5 / 12ILE B  88
LEU B  91
SER B 106
GLY B 110
GLY B 105
None
1.04A15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens)		5 / 12ILE A 657
LEU A 651
VAL A 658
ASP A 836
HIS A 816
748  A1001 ( 4.4A)
None
748  A1001 ( 4.8A)
748  A1001 (-4.8A)
748  A1001 (-3.8A)
1.19A19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		5k8r PROTOCADHERIN
GAMMA-B3
(Homo
sapiens)		5 / 12ILE A 352
HIS A 342
GLY A 350
ASP A 345
GLY A 398
None
None
CA  A 504 ( 4.7A)
CA  A 505 ( 3.2A)
None
1.19A19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens)		5 / 12ILE A 378
HIS A 100
GLY A 398
GLY A 396
HIS A 403
None
None
FAD  A 901 (-4.4A)
None
None
1.03A14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens)		5 / 12ILE A 247
LEU A 242
GLY A 329
ASP A 330
HIS A 310
FKY  A9001 (-4.1A)
FKY  A9001 (-4.7A)
FKY  A9001 (-3.4A)
None
FKY  A9001 (-3.9A)
0.94Aundetectable