POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZNC_A_BZ1A500_1
(CARBONIC ANHYDRASE
IV)		1jd0 CARBONIC ANHYDRASE
XII
(Homo
sapiens)		9 / 10GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 121
LEU A 198
THR A 199
THR A 200
TRP A 209
AZM  A1400 (-3.2A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.1A)
AZM  A1400 (-4.6A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
AZM  A1400 (-3.3A)
None
0.24A35.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZNC_A_BZ1A500_1
(CARBONIC ANHYDRASE
IV)		1jd0 CARBONIC ANHYDRASE
XII
(Homo
sapiens)		6 / 10HIS A  96
HIS A 119
LEU A 198
THR A 199
THR A 200
TRP A 209
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.1A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
AZM  A1400 (-3.3A)
None
1.48A35.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZNC_A_BZ1A500_1
(CARBONIC ANHYDRASE
IV)		1jd0 CARBONIC ANHYDRASE
XII
(Homo
sapiens)		5 / 10HIS A  96
VAL A 143
LEU A 198
THR A 199
THR A 200
 ZN  A 901 ( 3.2A)
AZM  A1400 ( 4.9A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
AZM  A1400 (-3.3A)
0.93A35.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZNC_A_BZ1A500_1
(CARBONIC ANHYDRASE
IV)		1jd0 CARBONIC ANHYDRASE
XII
(Homo
sapiens)		5 / 10HIS A 119
HIS A  96
VAL A 143
LEU A 198
THR A 199
 ZN  A 901 ( 3.1A)
ZN  A 901 ( 3.2A)
AZM  A1400 ( 4.9A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
1.45A35.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZNC_A_BZ1A500_1
(CARBONIC ANHYDRASE
IV)		2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens)		7 / 10GLN A  92
HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
TRP A 209
None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
0.45A33.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZNC_A_BZ1A500_1
(CARBONIC ANHYDRASE
IV)		2w2j CARBONIC
ANHYDRASE-RELATED
PROTEIN
(Homo
sapiens)		5 / 10HIS A 118
HIS A 141
LEU A 222
THR A 223
TRP A 233
 CL  A 401 (-4.2A)
CL  A 401 (-4.1A)
None
CL  A 401 ( 4.8A)
None
0.34A28.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZNC_A_BZ1A500_1
(CARBONIC ANHYDRASE
IV)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		8 / 10GLN A  93
HIS A  95
HIS A  97
HIS A 120
VAL A 122
LEU A 199
THR A 200
TRP A 210
4MD  A 401 (-3.1A)
ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.5A)
ZN  A 301 ( 3.2A)
4MD  A 401 ( 4.6A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
None
0.75A32.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZNC_A_BZ1A500_1
(CARBONIC ANHYDRASE
IV)		3fe4 CARBONIC ANHYDRASE 6
(Homo
sapiens)		8 / 10GLN A 109
HIS A 111
HIS A 113
HIS A 138
VAL A 140
LEU A 219
THR A 220
TRP A 230
None
MG  A 901 (-3.4A)
MG  A 901 (-3.4A)
MG  A 901 (-3.2A)
None
None
None
None
0.74A34.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZNC_A_BZ1A500_1
(CARBONIC ANHYDRASE
IV)		3fe4 CARBONIC ANHYDRASE 6
(Homo
sapiens)		5 / 10HIS A 111
HIS A 113
VAL A 161
LEU A 219
THR A 220
 MG  A 901 (-3.4A)
MG  A 901 (-3.4A)
None
None
None
1.20A34.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZNC_A_BZ1A500_1
(CARBONIC ANHYDRASE
IV)		3fe4 CARBONIC ANHYDRASE 6
(Homo
sapiens)		5 / 10HIS A 138
HIS A 113
VAL A 161
LEU A 219
THR A 220
 MG  A 901 (-3.2A)
MG  A 901 (-3.4A)
None
None
None
1.47A34.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZNC_A_BZ1A500_1
(CARBONIC ANHYDRASE
IV)		3fe4 CARBONIC ANHYDRASE 6
(Homo
sapiens)		5 / 10HIS A 138
HIS A 126
VAL A 161
LEU A 219
THR A 220
 MG  A 901 (-3.2A)
None
None
None
None
1.48A34.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZNC_A_BZ1A500_1
(CARBONIC ANHYDRASE
IV)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		6 / 10GLN A  67
HIS A  94
HIS A  96
HIS A 119
THR A 199
THR A 200
None
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.1A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
0.95A33.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZNC_A_BZ1A500_1
(CARBONIC ANHYDRASE
IV)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		9 / 10GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 121
LEU A 198
THR A 199
THR A 200
TRP A 209
AZM  A 264 (-4.1A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.1A)
AZM  A 264 (-4.7A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
None
0.47A33.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZNC_A_BZ1A500_1
(CARBONIC ANHYDRASE
IV)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		5 / 10GLN A  92
HIS A  94
VAL A 121
PHE A 131
THR A 200
AZM  A 264 (-4.1A)
ZN  A 263 ( 3.2A)
AZM  A 264 (-4.7A)
AZM  A 264 (-4.4A)
AZM  A 264 (-3.5A)
1.40A33.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZNC_A_BZ1A500_1
(CARBONIC ANHYDRASE
IV)		3uyq CARBONIC ANHYDRASE 3
(Homo
sapiens)		8 / 10GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 121
THR A 198
THR A 199
TRP A 208
None
ZN  A 261 (-3.3A)
ZN  A 261 (-3.3A)
ZN  A 261 (-3.2A)
None
ZN  A 261 ( 4.4A)
None
None
0.49A33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZNC_A_BZ1A500_1
(CARBONIC ANHYDRASE
IV)		3uyq CARBONIC ANHYDRASE 3
(Homo
sapiens)		5 / 10GLN A  92
HIS A  94
HIS A  96
VAL A 121
THR A 198
None
ZN  A 261 (-3.3A)
ZN  A 261 (-3.3A)
None
ZN  A 261 ( 4.4A)
1.32A33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZNC_A_BZ1A500_1
(CARBONIC ANHYDRASE
IV)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		9 / 10GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 121
LEU A 198
THR A 199
THR A 200
TRP A 209
None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 (-3.1A)
None
None
ZN  A 301 ( 4.4A)
None
None
0.42A35.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZNC_A_BZ1A500_1
(CARBONIC ANHYDRASE
IV)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		5 / 10GLN A  92
HIS A  94
VAL A 121
PHE A 131
THR A 200
None
ZN  A 301 (-3.2A)
None
None
None
1.41A35.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZNC_A_BZ1A500_1
(CARBONIC ANHYDRASE
IV)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		5 / 10HIS A  94
HIS A 119
THR A 199
THR A 200
TRP A 209
 ZN  A 301 (-3.2A)
ZN  A 301 (-3.1A)
ZN  A 301 ( 4.4A)
None
None
1.49A35.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZNC_A_BZ1A500_1
(CARBONIC ANHYDRASE
IV)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		6 / 10GLN A  67
HIS A  94
HIS A  96
HIS A 119
THR A 199
THR A 200
GOL  A 303 (-3.4A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
0.93A37.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZNC_A_BZ1A500_1
(CARBONIC ANHYDRASE
IV)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		9 / 10GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 121
LEU A 198
THR A 199
THR A 200
TRP A 209
GOL  A 303 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
None
0.44A37.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZNC_A_BZ1A500_1
(CARBONIC ANHYDRASE
IV)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		5 / 10HIS A  96
VAL A 143
LEU A 198
THR A 199
THR A 200
 ZN  A 301 ( 3.2A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
0.91A37.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZNC_A_BZ1A500_1
(CARBONIC ANHYDRASE
IV)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		5 / 10HIS A 119
HIS A  96
VAL A 143
LEU A 198
THR A 199
 ZN  A 301 ( 3.1A)
ZN  A 301 ( 3.2A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
1.47A37.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZNC_A_BZ1A500_1
(CARBONIC ANHYDRASE
IV)		5jn9 CARBONIC ANHYDRASE 4
(Homo
sapiens)		9 / 10GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 121
LEU A 198
THR A 199
THR A 200
TRP A 209
EZL  A 302 (-4.3A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.2A)
EZL  A 302 (-4.7A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.4A)
EZL  A 302 (-3.9A)
None
0.45A58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZNC_A_BZ1A500_1
(CARBONIC ANHYDRASE
IV)		5jn9 CARBONIC ANHYDRASE 4
(Homo
sapiens)		6 / 10GLN A  92
HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 199
EZL  A 302 (-4.3A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
EZL  A 302 (-4.7A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.4A)
1.49A58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZNC_A_BZ1A500_1
(CARBONIC ANHYDRASE
IV)		5jn9 CARBONIC ANHYDRASE 4
(Homo
sapiens)		5 / 10HIS A  94
HIS A  96
VAL A 143
LEU A 198
THR A 200
 ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
EZL  A 302 ( 4.7A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.9A)
1.12A58.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZNC_A_BZ1A500_1
(CARBONIC ANHYDRASE
IV)		6fe1 CARBONIC ANHYDRASE 9
(Homo
sapiens)		9 / 10GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 121
LEU A 198
THR A 199
THR A 200
TRP A 209
V14  A 302 (-3.8A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
V14  A 302 (-4.7A)
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
V14  A 302 (-3.5A)
None
0.46A16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZNC_A_BZ1A500_1
(CARBONIC ANHYDRASE
IV)		6fe1 CARBONIC ANHYDRASE 9
(Homo
sapiens)		6 / 10HIS A  94
HIS A  96
VAL A 143
LEU A 198
THR A 199
THR A 200
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
None
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
V14  A 302 (-3.5A)
1.02A16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZNC_A_BZ1A500_1
(CARBONIC ANHYDRASE
IV)		6fe1 CARBONIC ANHYDRASE 9
(Homo
sapiens)		5 / 10HIS A 119
HIS A  96
VAL A 143
LEU A 198
THR A 199
 ZN  A 301 ( 3.1A)
ZN  A 301 ( 3.2A)
None
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
1.40A16.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2R_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		1jd0 CARBONIC ANHYDRASE
XII
(Homo
sapiens)		11 / 12ASN A  62
GLN A  92
HIS A  94
HIS A  96
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
PRO A 202
TRP A 209
None
AZM  A1400 (-3.2A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.2A)
AZM  A1400 (-4.6A)
AZM  A1400 ( 4.9A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
AZM  A1400 (-3.3A)
None
None
0.42A36.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2R_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens)		8 / 12GLN A  92
HIS A  94
HIS A  96
VAL A 143
LEU A 198
THR A 199
PRO A 202
TRP A 209
None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
None
0.55A60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2R_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens)		5 / 12HIS A  96
VAL A 143
LEU A 198
THR A 199
PRO A 202
 ZN  A 561 ( 3.2A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
0.90A60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2R_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		2w2j CARBONIC
ANHYDRASE-RELATED
PROTEIN
(Homo
sapiens)		5 / 12HIS A 118
LEU A 222
THR A 223
PRO A 226
TRP A 233
 CL  A 401 (-4.2A)
None
CL  A 401 ( 4.8A)
None
None
0.30A38.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2R_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		6 / 12ASN A  68
HIS A  97
LEU A 199
THR A 200
PRO A 203
TRP A 210
None
ZN  A 301 ( 3.5A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
4MD  A 401 ( 4.9A)
None
1.11A59.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2R_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		5 / 12ASN A  68
HIS A  97
VAL A 144
LEU A 199
PRO A 203
None
ZN  A 301 ( 3.5A)
4MD  A 401 ( 4.4A)
4MD  A 401 (-4.2A)
4MD  A 401 ( 4.9A)
1.02A59.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2R_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		7 / 12GLN A  93
HIS A  95
HIS A  97
PHE A 132
LEU A 199
THR A 200
PRO A 203
4MD  A 401 (-3.1A)
ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.5A)
4MD  A 401 (-4.6A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
4MD  A 401 ( 4.9A)
0.90A59.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2R_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		9 / 12HIS A  95
HIS A  97
VAL A 122
PHE A 132
VAL A 144
LEU A 199
THR A 200
PRO A 203
TRP A 210
 ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.5A)
4MD  A 401 ( 4.6A)
4MD  A 401 (-4.6A)
4MD  A 401 ( 4.4A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
4MD  A 401 ( 4.9A)
None
0.45A59.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2R_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		5 / 12HIS A  97
VAL A 122
LEU A 199
THR A 200
PRO A 203
 ZN  A 301 ( 3.5A)
4MD  A 401 ( 4.6A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
4MD  A 401 ( 4.9A)
0.97A59.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		3e0l GUANINE DEAMINASE
(Homo
sapiens)		5 / 12GLN A  87
HIS A  84
HIS A  82
PHE A 108
VAL A 169
None
ZN  A1452 (-3.1A)
ZN  A1452 (-3.3A)
None
None
1.03A20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2R_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		3fe4 CARBONIC ANHYDRASE 6
(Homo
sapiens)		9 / 12ASN A  83
GLN A 109
HIS A 111
HIS A 113
VAL A 140
VAL A 161
LEU A 219
THR A 220
TRP A 230
None
None
MG  A 901 (-3.4A)
MG  A 901 (-3.4A)
None
None
None
None
None
0.70A34.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2R_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		3fe4 CARBONIC ANHYDRASE 6
(Homo
sapiens)		6 / 12HIS A 111
HIS A 113
VAL A 140
VAL A 161
LEU A 219
THR A 220
 MG  A 901 (-3.4A)
MG  A 901 (-3.4A)
None
None
None
None
1.46A34.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2R_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		3fe4 CARBONIC ANHYDRASE 6
(Homo
sapiens)		7 / 12HIS A 113
VAL A 140
VAL A 161
LEU A 219
THR A 220
PRO A 223
TRP A 230
 MG  A 901 (-3.4A)
None
None
None
None
None
None
0.75A34.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2R_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		3fe4 CARBONIC ANHYDRASE 6
(Homo
sapiens)		5 / 12LEU A 219
THR A 220
THR A 221
PRO A 223
TRP A 230
None
0.53A34.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		3jxf RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA
(Homo
sapiens)		5 / 12HIS A 129
LEU A 235
THR A 236
PRO A 239
TRP A 246
None
0.32A29.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2R_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		12 / 12ASN A  62
GLN A  92
HIS A  94
HIS A  96
VAL A 121
PHE A 131
VAL A 143
LEU A 198
THR A 199
THR A 200
PRO A 202
TRP A 209
None
AZM  A 264 (-4.1A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
AZM  A 264 (-4.7A)
AZM  A 264 (-4.4A)
AZM  A 264 ( 4.9A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
None
None
0.42A56.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2R_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		6 / 12ASN A  62
HIS A  94
VAL A 143
THR A 199
PRO A 201
TRP A 209
None
ZN  A 263 ( 3.2A)
AZM  A 264 ( 4.9A)
AZM  A 264 (-3.4A)
None
None
1.29A56.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2R_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		7 / 12GLN A  67
HIS A  96
VAL A 121
LEU A 198
THR A 199
THR A 200
PRO A 202
None
ZN  A 263 ( 3.2A)
AZM  A 264 (-4.7A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
None
1.22A56.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2R_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		7 / 12GLN A  92
HIS A  94
HIS A  96
VAL A 121
PHE A 131
LEU A 198
THR A 199
AZM  A 264 (-4.1A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
AZM  A 264 (-4.7A)
AZM  A 264 (-4.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
1.37A56.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2R_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		3uyq CARBONIC ANHYDRASE 3
(Homo
sapiens)		11 / 12ASN A  62
GLN A  92
HIS A  94
HIS A  96
VAL A 121
PHE A 130
VAL A 142
THR A 198
THR A 199
PRO A 201
TRP A 208
None
None
ZN  A 261 (-3.3A)
ZN  A 261 (-3.3A)
None
None
None
ZN  A 261 ( 4.4A)
None
None
None
0.54A58.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2R_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		3uyq CARBONIC ANHYDRASE 3
(Homo
sapiens)		6 / 12GLN A  92
HIS A  94
HIS A  96
VAL A 121
VAL A 142
THR A 198
None
ZN  A 261 (-3.3A)
ZN  A 261 (-3.3A)
None
None
ZN  A 261 ( 4.4A)
1.25A58.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2R_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		12 / 12ASN A  62
GLN A  92
HIS A  94
HIS A  96
VAL A 121
PHE A 131
VAL A 143
LEU A 198
THR A 199
THR A 200
PRO A 202
TRP A 209
None
None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
None
None
None
ZN  A 301 ( 4.4A)
None
None
None
0.19A95.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2R_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		6 / 12ASN A  67
HIS A  96
LEU A 198
THR A 199
THR A 200
PRO A 202
None
ZN  A 301 (-3.2A)
None
ZN  A 301 ( 4.4A)
None
None
1.02A95.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2R_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		6 / 12ASN A  67
HIS A  96
VAL A 143
LEU A 198
THR A 200
PRO A 202
None
ZN  A 301 (-3.2A)
None
None
None
None
1.00A95.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2R_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		7 / 12GLN A  92
HIS A  94
HIS A  96
VAL A 121
PHE A 131
LEU A 198
THR A 199
None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
None
None
ZN  A 301 ( 4.4A)
1.39A95.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2R_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		6 / 12HIS A  94
LEU A 198
THR A 199
THR A 200
PRO A 202
TRP A 209
 ZN  A 301 (-3.2A)
None
ZN  A 301 ( 4.4A)
None
None
None
1.28A95.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2R_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		6 / 12HIS A  96
VAL A 121
LEU A 198
THR A 199
THR A 200
PRO A 202
 ZN  A 301 (-3.2A)
None
None
ZN  A 301 ( 4.4A)
None
None
0.91A95.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2R_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		11 / 12ASN A  62
GLN A  92
HIS A  94
HIS A  96
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
PRO A 202
TRP A 209
GOL  A 303 (-3.9A)
GOL  A 303 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
520  A 302 ( 4.9A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
None
None
0.35A37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2R_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		6 / 12ASN A  62
HIS A  94
LEU A 198
THR A 199
PRO A 201
TRP A 209
GOL  A 303 (-3.9A)
ZN  A 301 (-3.2A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
None
None
1.47A37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2R_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		6 / 12GLN A  67
HIS A  96
VAL A 121
LEU A 198
THR A 199
THR A 200
GOL  A 303 (-3.4A)
ZN  A 301 ( 3.2A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
1.18A37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2R_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		6 / 12HIS A  96
VAL A 121
LEU A 198
THR A 199
THR A 200
PRO A 202
 ZN  A 301 ( 3.2A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
None
0.88A37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2R_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		5jn9 CARBONIC ANHYDRASE 4
(Homo
sapiens)		10 / 12ASN A  62
GLN A  92
HIS A  94
HIS A  96
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
None
EZL  A 302 (-4.3A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
EZL  A 302 (-4.7A)
EZL  A 302 ( 4.7A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.4A)
EZL  A 302 (-3.9A)
None
0.40A35.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		6fe1 CARBONIC ANHYDRASE 9
(Homo
sapiens)		11 / 12ASN A  62
GLN A  92
HIS A  94
HIS A  96
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
PRO A 202
TRP A 209
V14  A 302 (-3.4A)
V14  A 302 (-3.8A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
V14  A 302 (-4.7A)
None
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
V14  A 302 (-3.5A)
None
None
0.49A15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		6fe1 CARBONIC ANHYDRASE 9
(Homo
sapiens)		6 / 12HIS A  96
LEU A 198
THR A 199
THR A 200
PRO A 202
TRP A 209
 ZN  A 301 ( 3.2A)
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
V14  A 302 (-3.5A)
None
None
1.36A15.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		1jd0 CARBONIC ANHYDRASE
XII
(Homo
sapiens)		4 / 4HIS A  64
GLU A 106
HIS A 119
LEU A 141
None
ZN  A 901 ( 4.5A)
ZN  A 901 ( 3.1A)
None
0.20A36.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens)		4 / 4HIS A  82
GLU A 425
HIS A 553
LEU A 551
None
ZN  A1752 (-2.5A)
ZN  A1752 (-3.3A)
None
1.36A16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		2q9g CYTOCHROME P450 46A1
(Homo
sapiens)		4 / 4HIS A 310
GLU A 305
HIS A 304
LEU A 204
HEM  A 505 ( 4.6A)
None
None
None
1.01A20.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		4 / 4HIS A  65
GLU A 107
HIS A 120
LEU A 142
None
ZN  A 301 ( 4.9A)
ZN  A 301 ( 3.2A)
None
0.27A59.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		3fe4 CARBONIC ANHYDRASE 6
(Homo
sapiens)		4 / 4HIS A  85
GLU A 125
HIS A 138
LEU A 159
None
MG  A 901 ( 4.4A)
MG  A 901 (-3.2A)
None
0.56A34.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		4 / 4HIS A  64
GLU A 106
HIS A 119
LEU A 141
None
ZN  A 263 ( 4.6A)
ZN  A 263 ( 3.1A)
None
0.35A56.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		3mpx FYVE, RHOGEF AND PH
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens)		4 / 4HIS A1096
GLU A1117
HIS A1132
LEU A1153
None
1.33A21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		3obz PHYTANOYL-COA
DIOXYGENASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		4 / 4HIS A 156
GLU A 243
HIS A 241
LEU A 264
FE2  A 482 ( 3.4A)
None
None
None
1.41A21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		4c6o CAD PROTEIN
(Homo
sapiens)		4 / 4HIS A1770
GLU A1694
HIS A1690
LEU A1474
None
None
FMT  A2824 (-4.2A)
None
1.25A22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4
(Homo
sapiens)		4 / 4HIS A  48
GLU A  55
HIS A 352
LEU A  29
None
1.43A19.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		4 / 4HIS A  64
GLU A 106
HIS A 119
LEU A 141
None
ZN  A 301 ( 4.6A)
ZN  A 301 ( 3.1A)
None
0.15A37.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens)		4 / 4HIS A 517
GLU A 463
HIS A 465
LEU A 480
None
1.38A17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		5l7k PROTEIN UNC-119
HOMOLOG A
(Homo
sapiens)		4 / 4HIS A 192
GLU A 163
HIS A 165
LEU A 140
None
1.44A21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		5m3x ANGIOTENSINOGEN
(Homo
sapiens)		4 / 4HIS A 288
GLU A 420
HIS A 345
LEU A 280
None
1.47A15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		6fe1 CARBONIC ANHYDRASE 9
(Homo
sapiens)		4 / 4HIS A  64
GLU A 106
HIS A 119
LEU A 141
None
V14  A 302 (-4.2A)
ZN  A 301 ( 3.1A)
None
0.38A15.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2V_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		1jd0 CARBONIC ANHYDRASE
XII
(Homo
sapiens)		9 / 12GLN A  92
HIS A  94
HIS A  96
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
AZM  A1400 (-3.2A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.2A)
AZM  A1400 (-4.6A)
AZM  A1400 ( 4.9A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
AZM  A1400 (-3.3A)
None
0.34A36.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2V_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens)		7 / 12GLN A  92
HIS A  94
HIS A  96
VAL A 143
LEU A 198
THR A 199
TRP A 209
None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
0.53A60.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		2jbh PHOSPHORIBOSYLTRANSF
ERASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		5 / 12LEU A 138
VAL A  71
GLY A  65
VAL A 100
VAL A 104
None
None
None
None
CAS  A  82 ( 4.2A)
0.82A21.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2V_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		2w2j CARBONIC
ANHYDRASE-RELATED
PROTEIN
(Homo
sapiens)		5 / 12HIS A 118
VAL A 157
LEU A 222
THR A 223
TRP A 233
 CL  A 401 (-4.2A)
None
None
CL  A 401 ( 4.8A)
None
0.43A38.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2V_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		6 / 12GLN A  93
HIS A  95
HIS A  97
VAL A 122
LEU A 199
THR A 200
4MD  A 401 (-3.1A)
ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.5A)
4MD  A 401 ( 4.6A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
0.92A58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2V_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		7 / 12HIS A  95
HIS A  97
VAL A 122
VAL A 144
LEU A 199
THR A 200
TRP A 210
 ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.5A)
4MD  A 401 ( 4.6A)
4MD  A 401 ( 4.4A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
None
0.43A58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2V_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		3fe4 CARBONIC ANHYDRASE 6
(Homo
sapiens)		8 / 12GLN A 109
HIS A 111
HIS A 113
VAL A 140
VAL A 161
LEU A 219
THR A 220
TRP A 230
None
MG  A 901 (-3.4A)
MG  A 901 (-3.4A)
None
None
None
None
None
0.62A34.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2V_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		3fe4 CARBONIC ANHYDRASE 6
(Homo
sapiens)		6 / 12HIS A 111
HIS A 113
VAL A 140
VAL A 161
LEU A 219
THR A 220
 MG  A 901 (-3.4A)
MG  A 901 (-3.4A)
None
None
None
None
1.48A34.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		3jxf RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA
(Homo
sapiens)		5 / 12HIS A 129
VAL A 170
LEU A 235
THR A 236
TRP A 246
None
0.72A29.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2V_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		6 / 12GLN A  67
HIS A  96
VAL A 121
LEU A 198
THR A 199
THR A 200
None
ZN  A 263 ( 3.2A)
AZM  A 264 (-4.7A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
1.20A56.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2V_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		7 / 12GLN A  92
HIS A  94
HIS A  96
VAL A 121
GLY A 132
LEU A 198
THR A 199
AZM  A 264 (-4.1A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
AZM  A 264 (-4.7A)
None
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
1.40A56.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2V_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		10 / 12GLN A  92
HIS A  94
HIS A  96
VAL A 121
GLY A 132
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
AZM  A 264 (-4.1A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
AZM  A 264 (-4.7A)
None
AZM  A 264 ( 4.9A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
None
0.30A56.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		3ow8 WD REPEAT-CONTAINING
PROTEIN 61
(Homo
sapiens)		5 / 12LEU A 204
HIS A 189
VAL A 206
GLY A 262
LEU A 228
None
0.97A21.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2V_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		3uyq CARBONIC ANHYDRASE 3
(Homo
sapiens)		6 / 12GLN A  92
HIS A  94
HIS A  96
VAL A 121
VAL A 142
THR A 198
None
ZN  A 261 (-3.3A)
ZN  A 261 (-3.3A)
None
None
ZN  A 261 ( 4.4A)
1.25A57.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2V_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		3uyq CARBONIC ANHYDRASE 3
(Homo
sapiens)		8 / 12GLN A  92
HIS A  94
HIS A  96
VAL A 121
VAL A 142
THR A 198
THR A 199
TRP A 208
None
ZN  A 261 (-3.3A)
ZN  A 261 (-3.3A)
None
None
ZN  A 261 ( 4.4A)
None
None
0.38A57.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2V_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		11 / 12GLN A  92
HIS A  94
HIS A  96
VAL A 121
GLY A 132
VAL A 135
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
None
None
None
None
ZN  A 301 ( 4.4A)
None
None
0.22A92.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2V_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		7 / 12GLN A  92
HIS A  94
HIS A  96
VAL A 121
VAL A 135
LEU A 198
THR A 199
None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
None
None
ZN  A 301 ( 4.4A)
1.43A92.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2V_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		5 / 12HIS A  96
VAL A 121
LEU A 198
THR A 199
THR A 200
 ZN  A 301 (-3.2A)
None
None
ZN  A 301 ( 4.4A)
None
0.89A92.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2V_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		5 / 12HIS A  96
VAL A 143
VAL A 135
LEU A 198
THR A 200
 ZN  A 301 (-3.2A)
None
None
None
None
0.93A92.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2V_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		6 / 12GLN A  67
HIS A  96
VAL A 121
LEU A 198
THR A 199
THR A 200
GOL  A 303 (-3.4A)
ZN  A 301 ( 3.2A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
1.15A38.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2V_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		9 / 12GLN A  92
HIS A  94
HIS A  96
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
GOL  A 303 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
520  A 302 ( 4.9A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
None
0.20A38.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2V_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		6 / 12LEU A 131
HIS A  94
HIS A  96
VAL A 143
THR A 200
TRP A 209
520  A 302 ( 4.8A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
520  A 302 ( 4.9A)
GOL  A 303 ( 3.5A)
None
1.00A38.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2V_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		5jn9 CARBONIC ANHYDRASE 4
(Homo
sapiens)		6 / 12GLN A  92
HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 199
EZL  A 302 (-4.3A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
EZL  A 302 (-4.7A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.4A)
1.44A36.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M2V_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		5jn9 CARBONIC ANHYDRASE 4
(Homo
sapiens)		9 / 12GLN A  92
HIS A  94
HIS A  96
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
EZL  A 302 (-4.3A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
EZL  A 302 (-4.7A)
EZL  A 302 ( 4.7A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.4A)
EZL  A 302 (-3.9A)
None
0.33A36.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		6fe1 CARBONIC ANHYDRASE 9
(Homo
sapiens)		10 / 12LEU A  91
GLN A  92
HIS A  94
HIS A  96
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
None
V14  A 302 (-3.8A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
V14  A 302 (-4.7A)
None
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
V14  A 302 (-3.5A)
None
0.59A14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		1bnl COLLAGEN XVIII
(Homo
sapiens)		3 / 3HIS A 121
VAL A 108
LEU A 152
None
0.76A24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		1dkt CYCLIN DEPENDENT
KINASE SUBUNIT, TYPE
1
(Homo
sapiens)		3 / 3HIS A  60
VAL A  48
LEU A  24
None
0.77A16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		1ly7 FRATAXIN
(Homo
sapiens)		3 / 3HIS A 183
VAL A 125
LEU A 132
None
0.61A18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		1o1j HEMOGLOBIN ALPHA
CHAIN
(Homo
sapiens)		3 / 3HIS A 122
VAL A  17
LEU A 113
None
0.70A22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens)		3 / 3HIS A 285
VAL A 407
LEU A 292
None
0.77A23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens)		3 / 3HIS A 473
VAL A 467
LEU A 469
None
0.77A22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		1w6j LANOSTEROL SYNTHASE
(Homo
sapiens)		3 / 3HIS A 403
VAL A  85
LEU A 396
None
0.64A16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		1xfd DIPEPTIDYL
AMINOPEPTIDASE-LIKE
PROTEIN 6
(Homo
sapiens)		3 / 3HIS A 301
VAL A 386
LEU A 298
None
0.73A17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens)		3 / 3HIS B  79
VAL B  55
LEU B 220
None
0.72A18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		2b5i CYTOKINE RECEPTOR
COMMON GAMMA CHAIN
(Homo
sapiens)		3 / 3HIS C  82
VAL C 108
LEU C  65
None
0.76A20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		2c3n GLUTATHIONE
S-TRANSFERASE THETA
1
(Homo
sapiens)		3 / 3HIS A 116
VAL A 184
LEU A 140
None
0.75A22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		2dm8 INAD-LIKE PROTEIN
(Homo
sapiens)		3 / 3HIS A  81
VAL A  74
LEU A  76
None
0.67A16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		2eeg PDZ AND LIM DOMAIN
PROTEIN 4
(Homo
sapiens)		3 / 3HIS A  40
VAL A  12
LEU A  14
None
0.66A19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		2ell ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER B
(Homo
sapiens)		3 / 3HIS A  99
VAL A 142
LEU A 149
None
0.75A19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		2ggt SCO1 PROTEIN
HOMOLOG,
MITOCHONDRIAL
(Homo
sapiens)		3 / 3HIS A 145
VAL A 234
LEU A 142
None
0.57A21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		2i6t UBIQUITIN-CONJUGATIN
G ENZYME E2-LIKE
ISOFORM A
(Homo
sapiens)		3 / 3HIS A 463
VAL A 266
LEU A 469
None
0.64A22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		2j0u ATP-DEPENDENT RNA
HELICASE DDX48
(Homo
sapiens)		3 / 3HIS A 138
VAL A  96
LEU A 126
None
0.61A20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		2kk1 TYROSINE-PROTEIN
KINASE ABL2
(Homo
sapiens)		3 / 3HIS A  67
VAL A 126
LEU A  96
None
0.72A17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		2pey BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1 (PAPS
SYNTHETASE 1) (PAPSS
1) (SULFURYLASE
KINASE 1) (SK1) (SK
1)
(Homo
sapiens)		3 / 3HIS A  79
VAL A  55
LEU A 220
None
0.77A20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		2r3v MEVALONATE KINASE
(Homo
sapiens)		3 / 3HIS A  17
VAL A 310
LEU A 331
None
0.76A22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		2rjq ADAMTS-5
(Homo
sapiens)		3 / 3HIS A 346
VAL A 319
LEU A 272
None
0.63A21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		2wbi ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 11
(Homo
sapiens)		3 / 3HIS A 283
VAL A 370
LEU A 290
UNX  A1428 (-4.6A)
None
None
0.76A19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		1jd0 CARBONIC ANHYDRASE
XII
(Homo
sapiens)		9 / 12ASN A  62
HIS A  64
GLN A  92
HIS A  94
HIS A  96
LEU A 198
THR A 199
THR A 200
TRP A 209
None
None
AZM  A1400 (-3.2A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.2A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
AZM  A1400 (-3.3A)
None
0.58A15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		1jd0 CARBONIC ANHYDRASE
XII
(Homo
sapiens)		9 / 12TRP A   5
ASN A  62
HIS A  64
HIS A  94
HIS A  96
LEU A 198
THR A 199
THR A 200
TRP A 209
None
None
None
ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.2A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
AZM  A1400 (-3.3A)
None
0.55A15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		1jd0 CARBONIC ANHYDRASE
XII
(Homo
sapiens)		6 / 12TRP A   5
HIS A  64
HIS A  94
THR A 199
THR A 200
TRP A 209
None
None
ZN  A 901 ( 3.2A)
AZM  A1400 (-3.6A)
AZM  A1400 (-3.3A)
None
1.33A15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		1jd0 CARBONIC ANHYDRASE
XII
(Homo
sapiens)		6 / 12TRP A  16
GLN A  92
HIS A  94
HIS A  96
LEU A 198
THR A 200
None
AZM  A1400 (-3.2A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.2A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.3A)
1.45A15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens)		7 / 12TRP A   5
GLN A  92
HIS A  94
HIS A  96
LEU A 198
THR A 199
TRP A 209
None
None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
0.72A19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		2w2j CARBONIC
ANHYDRASE-RELATED
PROTEIN
(Homo
sapiens)		5 / 12HIS A  87
ILE A 153
HIS A 118
THR A 223
TRP A 233
None
UNX  A 603 ( 4.9A)
CL  A 401 (-4.2A)
CL  A 401 ( 4.8A)
None
0.81A22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		2w2j CARBONIC
ANHYDRASE-RELATED
PROTEIN
(Homo
sapiens)		6 / 12TRP A  29
HIS A  87
HIS A 118
LEU A 222
THR A 223
TRP A 233
None
None
CL  A 401 (-4.2A)
None
CL  A 401 ( 4.8A)
None
0.57A22.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		7 / 12HIS A  65
GLN A  93
HIS A  95
HIS A  97
LEU A 199
THR A 200
TRP A 210
None
4MD  A 401 (-3.1A)
ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.5A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
None
0.97A30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		7 / 12HIS A  65
GLN A  93
HIS A  97
PHE A 132
LEU A 199
THR A 200
TRP A 210
None
4MD  A 401 (-3.1A)
ZN  A 301 ( 3.5A)
4MD  A 401 (-4.6A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
None
1.03A30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		7 / 12TRP A   6
HIS A  65
HIS A  95
HIS A  97
LEU A 199
THR A 200
TRP A 210
None
None
ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.5A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
None
0.69A30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		7 / 12TRP A   6
HIS A  65
HIS A  97
PHE A 132
LEU A 199
THR A 200
TRP A 210
None
None
ZN  A 301 ( 3.5A)
4MD  A 401 (-4.6A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
None
0.72A30.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		3fe4 CARBONIC ANHYDRASE 6
(Homo
sapiens)		8 / 12ASN A  83
HIS A  85
GLN A 109
HIS A 111
HIS A 113
LEU A 219
THR A 220
TRP A 230
None
None
None
MG  A 901 (-3.4A)
MG  A 901 (-3.4A)
None
None
None
0.70A16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		3jxf RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA
(Homo
sapiens)		5 / 12TRP A  38
HIS A 129
LEU A 235
THR A 236
TRP A 246
None
0.57A12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		7 / 12ASN A  62
HIS A  64
GLN A  92
HIS A  94
HIS A  96
PHE A 131
THR A 200
None
None
AZM  A 264 (-4.1A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
AZM  A 264 (-4.4A)
AZM  A 264 (-3.5A)
0.78A18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		6 / 12GLN A  67
HIS A  94
HIS A  96
LEU A 198
THR A 199
THR A 200
None
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
1.13A18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		10 / 12TRP A   5
ASN A  62
HIS A  64
GLN A  92
HIS A  94
HIS A  96
LEU A 198
THR A 199
THR A 200
TRP A 209
None
None
None
AZM  A 264 (-4.1A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
None
0.59A18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		6 / 12TRP A   5
HIS A  64
HIS A  94
THR A 199
THR A 200
TRP A 209
None
None
ZN  A 263 ( 3.2A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
None
1.36A18.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		3uyq CARBONIC ANHYDRASE 3
(Homo
sapiens)		10 / 12TRP A   5
ASN A  62
HIS A  64
GLN A  92
HIS A  94
HIS A  96
PHE A 130
THR A 198
THR A 199
TRP A 208
None
None
None
None
ZN  A 261 (-3.3A)
ZN  A 261 (-3.3A)
None
ZN  A 261 ( 4.4A)
None
None
0.73A32.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		3uyq CARBONIC ANHYDRASE 3
(Homo
sapiens)		6 / 12TRP A   5
HIS A  64
HIS A  94
THR A 198
THR A 199
TRP A 208
None
None
ZN  A 261 (-3.3A)
ZN  A 261 ( 4.4A)
None
None
1.40A32.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		4bdu GREEN FLUORESCENT
PROTEIN, APOPTOSIS
REGULATOR BAX
(Aequorea
victoria;
Homo
sapiens)		5 / 12HIS A 148
ILE A 161
PHE A  84
THR A  63
THR A  62
CR2  A  65 ( 4.3A)
None
None
None
None
1.20A13.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		6 / 12HIS A 107
HIS A  96
LEU A 203
THR A 200
THR A 199
TRP A   5
None
ZN  A 301 (-3.2A)
None
None
ZN  A 301 ( 4.4A)
None
1.42A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		11 / 12TRP A   5
ASN A  62
ILE A  91
GLN A  92
HIS A  94
HIS A  96
PHE A 131
LEU A 198
THR A 199
THR A 200
TRP A 209
None
None
None
None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
None
ZN  A 301 ( 4.4A)
None
None
0.70A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		5 / 12TRP A   5
HIS A  94
THR A 199
THR A 200
TRP A 209
None
ZN  A 301 (-3.2A)
ZN  A 301 ( 4.4A)
None
None
1.03A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		6 / 12TRP A 209
HIS A 107
LEU A 203
THR A 200
THR A 199
TRP A   5
None
None
None
None
ZN  A 301 ( 4.4A)
None
1.39A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		7 / 12GLN A  67
HIS A  94
HIS A  96
LEU A 198
THR A 199
THR A 200
TRP A 209
GOL  A 303 (-3.4A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
None
1.13A24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		10 / 12TRP A   5
ASN A  62
HIS A  64
GLN A  92
HIS A  94
HIS A  96
LEU A 198
THR A 199
THR A 200
TRP A 209
None
GOL  A 303 (-3.9A)
None
GOL  A 303 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
None
0.52A24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		7 / 12TRP A   5
HIS A  64
HIS A  94
LEU A 198
THR A 199
THR A 200
TRP A 209
None
None
ZN  A 301 (-3.2A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
None
1.48A24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		5jn9 CARBONIC ANHYDRASE 4
(Homo
sapiens)		5 / 12HIS A 107
HIS A  96
THR A 200
THR A 199
TRP A   5
None
ZN  A 301 ( 3.3A)
EZL  A 302 (-3.9A)
EZL  A 302 (-3.4A)
None
1.18A13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		5jn9 CARBONIC ANHYDRASE 4
(Homo
sapiens)		9 / 12TRP A   5
ASN A  62
GLN A  92
HIS A  94
HIS A  96
LEU A 198
THR A 199
THR A 200
TRP A 209
None
None
EZL  A 302 (-4.3A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.4A)
EZL  A 302 (-3.9A)
None
0.61A13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		5jn9 CARBONIC ANHYDRASE 4
(Homo
sapiens)		5 / 12TRP A   5
HIS A  94
THR A 199
THR A 200
TRP A 209
None
ZN  A 301 ( 3.3A)
EZL  A 302 (-3.4A)
EZL  A 302 (-3.9A)
None
1.19A13.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		6fe1 CARBONIC ANHYDRASE 9
(Homo
sapiens)		10 / 12TRP A   5
ASN A  62
HIS A  64
GLN A  92
HIS A  94
HIS A  96
LEU A 198
THR A 199
THR A 200
TRP A 209
None
V14  A 302 (-3.4A)
None
V14  A 302 (-3.8A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
V14  A 302 (-3.5A)
None
0.63A33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		6fe1 CARBONIC ANHYDRASE 9
(Homo
sapiens)		6 / 12TRP A   5
HIS A  64
HIS A  94
THR A 199
THR A 200
TRP A 209
None
None
ZN  A 301 ( 3.2A)
V14  A 302 (-3.2A)
V14  A 302 (-3.5A)
None
1.46A33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		6fe1 CARBONIC ANHYDRASE 9
(Homo
sapiens)		6 / 12TRP A   5
HIS A  64
HIS A  96
LEU A 198
THR A 200
TRP A 209
None
None
ZN  A 301 ( 3.2A)
V14  A 302 (-3.6A)
V14  A 302 (-3.5A)
None
1.32A33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		6fe1 CARBONIC ANHYDRASE 9
(Homo
sapiens)		6 / 12TRP A  16
GLN A  92
HIS A  94
HIS A  96
LEU A 198
THR A 200
None
V14  A 302 (-3.8A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
V14  A 302 (-3.6A)
V14  A 302 (-3.5A)
1.47A33.33