POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		1ggz CALMODULIN-RELATED
PROTEIN NB-1
(Homo
sapiens)		6 / 11PHE A  19
ILE A  27
LEU A  32
MET A  36
LEU A  39
MET A  51
None
0.60A43.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		1wrk TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES
(Homo
sapiens)		5 / 11ILE A  36
LEU A  41
MET A  45
LEU A  48
MET A  60
None
None
TFP  A 202 (-3.6A)
TFP  A 202 (-4.1A)
TFP  A 202 ( 4.0A)
0.55A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		1wrk TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES
(Homo
sapiens)		5 / 11LEU A  41
MET A  45
LEU A  48
MET A  60
VAL A  64
None
TFP  A 202 (-3.6A)
TFP  A 202 (-4.1A)
TFP  A 202 ( 4.0A)
None
0.48A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		1zot CALMODULIN
(Homo
sapiens)		7 / 11PHE B  92
ILE B 100
LEU B 105
MET B 109
LEU B 112
MET B 124
MET B 144
None
0.72A30.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		2d58 ALLOGRAFT
INFLAMMATORY FACTOR
1
(Homo
sapiens)		5 / 11PHE A  57
ILE A  65
LEU A  70
LEU A  77
VAL A  93
None
0.95A24.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		2ggm CENTRIN-2
(Homo
sapiens)		5 / 11LEU A  53
MET A  57
LEU A  60
MET A  72
GLU A  99
None
1.05A37.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		2ggm CENTRIN-2
(Homo
sapiens)		5 / 11PHE A 113
ILE A 121
LEU A 126
LEU A 133
MET A 145
None
0.51A37.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		2jjz IONIZED
CALCIUM-BINDING
ADAPTER MOLECULE 2
(Homo
sapiens)		8 / 11PHE B  59
ILE B  67
LEU B  72
MET B  76
LEU B  79
MET B  91
VAL B  95
MET B 111
None
0.75A27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		2k7d CALCIUM-BINDING
PROTEIN 1
(Homo
sapiens)		6 / 11PHE A 111
ILE A 119
LEU A 124
MET A 128
LEU A 131
VAL A 148
None
1.19A21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		2lv7 CALCIUM-BINDING
PROTEIN 7
(Homo
sapiens)		5 / 11PHE A  42
ILE A  53
LEU A  58
MET A  62
LEU A  65
None
1.03A21.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		2n6a HUMAN
CALMODULIN/CONNEXIN-
36 PEPTIDE HYBRID
(Homo
sapiens)		6 / 11PHE A  19
ILE A  27
LEU A  32
LEU A  39
VAL A  55
MET A  71
None
1.09A45.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		2n6a HUMAN
CALMODULIN/CONNEXIN-
36 PEPTIDE HYBRID
(Homo
sapiens)		6 / 11PHE A  19
ILE A  27
LEU A  32
MET A  36
LEU A  39
MET A  51
None
1.11A45.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		2n6a HUMAN
CALMODULIN/CONNEXIN-
36 PEPTIDE HYBRID
(Homo
sapiens)		6 / 11PHE A  19
ILE A  27
LEU A  32
MET A  36
LEU A  39
VAL A  55
None
1.07A45.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		2n6a HUMAN
CALMODULIN/CONNEXIN-
36 PEPTIDE HYBRID
(Homo
sapiens)		6 / 11PHE A  92
ILE A 100
LEU A 105
MET A 109
LEU A 112
MET A 124
None
0.79A45.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		2n7l TROPONIN C/TROPONIN
I CHIMERA
(Homo
sapiens)		5 / 11ILE C  36
LEU C  41
MET C  45
LEU C  48
VAL C  64
4J4  C  84 ( 4.3A)
4J4  C  84 ( 4.1A)
None
None
4J4  C  84 ( 3.7A)
1.00A56.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		2obh CENTRIN-2
(Homo
sapiens)		5 / 11PHE A 113
ILE A 121
LEU A 126
LEU A 133
MET A 145
None
0.52A40.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		5 / 11LEU A  96
VAL A 106
GLU A 150
LEU A 149
LEU A 146
LEU  A  96 ( 0.5A)
VAL  A 106 ( 0.6A)
GLU  A 150 ( 0.5A)
LEU  A 149 ( 0.6A)
LEU  A 146 ( 0.5A)
1.04A19.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		4gow CALMODULIN
(Homo
sapiens)		6 / 11ILE D 100
LEU D 105
MET D 109
LEU D 112
MET D 124
MET D 144
ILE  D 100 ( 0.7A)
LEU  D 105 ( 0.6A)
MET  D 109 ( 0.0A)
LEU  D 112 ( 0.6A)
MET  D 124 ( 0.0A)
MET  D 144 ( 0.0A)
0.96A53.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		4gow CALMODULIN
(Homo
sapiens)		6 / 11ILE D 100
LEU D 105
MET D 109
LEU D 112
MET D 124
MET D 145
ILE  D 100 ( 0.7A)
LEU  D 105 ( 0.6A)
MET  D 109 ( 0.0A)
LEU  D 112 ( 0.6A)
MET  D 124 ( 0.0A)
MET  D 145 ( 0.0A)
1.33A53.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		4gow CALMODULIN
(Homo
sapiens)		6 / 11ILE D 100
LEU D 105
MET D 109
LEU D 112
MET D 145
LEU D  18
ILE  D 100 ( 0.7A)
LEU  D 105 ( 0.6A)
MET  D 109 ( 0.0A)
LEU  D 112 ( 0.6A)
MET  D 145 ( 0.0A)
LEU  D  18 ( 0.6A)
1.35A53.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		4gow CALMODULIN
(Homo
sapiens)		8 / 11PHE D  19
ILE D  27
LEU D  32
MET D  36
LEU D  39
MET D  51
VAL D  55
MET D  71
PHE  D  19 ( 1.3A)
ILE  D  27 ( 0.7A)
LEU  D  32 ( 0.6A)
MET  D  36 ( 0.0A)
LEU  D  39 ( 0.5A)
MET  D  51 ( 0.0A)
VAL  D  55 ( 0.6A)
MET  D  71 ( 0.0A)
0.74A53.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		4gow CALMODULIN
(Homo
sapiens)		6 / 11PHE D  92
ILE D 100
LEU D 105
LEU D 112
MET D 124
MET D 144
PHE  D  92 ( 1.3A)
ILE  D 100 ( 0.7A)
LEU  D 105 ( 0.6A)
LEU  D 112 ( 0.6A)
MET  D 124 ( 0.0A)
MET  D 144 ( 0.0A)
0.79A53.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		4gow CALMODULIN
(Homo
sapiens)		6 / 11PHE D  92
ILE D 100
LEU D 105
LEU D 112
MET D 124
MET D 145
PHE  D  92 ( 1.3A)
ILE  D 100 ( 0.7A)
LEU  D 105 ( 0.6A)
LEU  D 112 ( 0.6A)
MET  D 124 ( 0.0A)
MET  D 145 ( 0.0A)
1.26A53.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		4gow CALMODULIN
(Homo
sapiens)		6 / 11PHE D  92
ILE D 100
LEU D 105
LEU D 112
MET D 145
LEU D  18
PHE  D  92 ( 1.3A)
ILE  D 100 ( 0.7A)
LEU  D 105 ( 0.6A)
LEU  D 112 ( 0.6A)
MET  D 145 ( 0.0A)
LEU  D  18 ( 0.6A)
1.29A53.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		4q57 CALMODULIN
(Homo
sapiens)		7 / 11PHE A  19
ILE A  27
LEU A  32
LEU A  39
MET A  51
VAL A  55
MET A  71
None
0.62A42.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		4q57 CALMODULIN
(Homo
sapiens)		7 / 11PHE A  19
ILE A  27
LEU A  32
MET A  36
MET A  51
VAL A  55
MET A  71
None
0.66A42.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		5coc IMMUNOGLOBULIN
G-BINDING PROTEIN
A,CALMODULIN
(Homo
sapiens;
Staphylococcus
aureus)		8 / 11PHE A1020
ILE A1028
LEU A1033
MET A1037
LEU A1040
MET A1052
VAL A1056
MET A1072
None
0.55A40.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		5i2q EF-HAND
DOMAIN-CONTAINING
PROTEIN D2
(Homo
sapiens)		5 / 11LEU A 117
MET A 121
LEU A 124
MET A 136
VAL A 140
None
0.77A26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		5lfn CHONDROADHERIN
(Homo
sapiens)		6 / 11ILE A  46
LEU A  58
LEU A 106
VAL A  49
MET A  74
LEU A 104
None
1.23A21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		5owo CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens)		5 / 11ILE A 125
LEU A  30
LEU A  37
MET A  65
LEU A 116
None
1.04A19.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		5w88 TROPONIN C, TROPONIN
I
(Homo
sapiens)		7 / 11PHE A  27
ILE A  36
LEU A  41
MET A  45
LEU A  48
MET A  60
VAL A  64
9XG  A 201 (-3.8A)
9XG  A 201 ( 3.3A)
9XG  A 201 (-3.9A)
9XG  A 201 (-2.4A)
9XG  A 201 ( 4.8A)
9XG  A 201 (-4.0A)
None
0.78A65.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		6ez8 HUNTINGTIN
(Homo
sapiens)		5 / 11ILE A 106
LEU A 121
LEU A 166
LEU A 192
LEU A 189
None
1.01A11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens)		5 / 12ILE A 288
PHE A 296
LEU A 232
MET A 236
LEU A  88
None
1.12A21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		1ln1 PHOSPHATIDYLCHOLINE
TRANSFER PROTEIN
(Homo
sapiens)		5 / 12ILE A  71
PHE A 199
LEU A 200
MET A 203
MET A 173
None
DLP  A2313 (-3.4A)
None
DLP  A2313 (-4.2A)
DLP  A2313 (-4.2A)
1.09A24.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		1wrk TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES
(Homo
sapiens)		5 / 12ALA A  23
ILE A  26
PHE A  77
MET A  81
LEU A  48
TFP  A 204 ( 4.7A)
None
None
TFP  A 202 ( 3.3A)
TFP  A 202 (-4.1A)
0.71A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		2b4x ANTITHROMBIN-III
(Homo
sapiens)		5 / 12ALA I  86
ILE I  83
PHE I 344
LEU I 340
LEU I 102
None
1.15A17.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		2n7l TROPONIN C/TROPONIN
I CHIMERA
(Homo
sapiens)		5 / 12ALA C  23
ILE C  26
PHE C  27
MET C  81
LEU C 111
None
None
None
4J4  C  84 ( 4.7A)
None
0.92A56.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		2q6z UROPORPHYRINOGEN
DECARBOXYLASE
(Homo
sapiens)		5 / 12ALA A 262
ILE A 260
PHE A 229
LEU A 301
LEU A 282
None
1.17A20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens)		5 / 12LEU A 195
PHE A 165
LEU A 182
LEU A 180
PHE A 171
None
1.13A14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		4cca SYNTAXIN-BINDING
PROTEIN 2
(Homo
sapiens)		5 / 12ALA A 202
ILE A 232
LEU A 156
MET A 539
LEU A 169
None
1.09A15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		4flc ADENYLOSUCCINATE
LYASE
(Homo
sapiens)		5 / 12ALA A 127
ILE A 123
PHE A  30
LEU A 252
LEU A 193
None
1.15A17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		4hva CASPASE-6
(Homo
sapiens)		5 / 12ILE A 159
LEU A 286
PHE A 288
LEU A  81
LEU A 236
None
1.19A21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		4k6j WINGS APART-LIKE
PROTEIN HOMOLOG
(Homo
sapiens)		5 / 12ALA A 682
ILE A 726
LEU A 707
PHE A 704
LEU A 694
None
1.09A14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		5a1n AMINOACYL TRNA
SYNTHASE
COMPLEX-INTERACTING
MULTIFUNCTIONAL
PROTEIN 2
(Homo
sapiens)		5 / 12ALA B 214
ILE B 213
LEU B 183
LEU B 142
PHE B 221
None
None
None
None
GOL  B1321 (-3.8A)
1.01A21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		5a1n AMINOACYL TRNA
SYNTHASE
COMPLEX-INTERACTING
MULTIFUNCTIONAL
PROTEIN 2
BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens)		5 / 12ILE B 213
LEU A  72
LEU B 183
LEU B 142
PHE B 221
None
None
None
None
GOL  B1321 (-3.8A)
1.04A21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		5lcw MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
BETA,MITOTIC
CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
BETA
(Homo
sapiens)		5 / 12ALA S 171
ILE S 174
PHE S 175
PHE S 196
LEU S 136
None
1.19A18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		5lxr RNA-BINDING PROTEIN
7
ZINC FINGER CCHC
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens)		5 / 12PHE B 286
LEU A  69
PHE B 309
LEU B 299
LEU B 295
None
1.17A17.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		5w88 TROPONIN C, TROPONIN
I
(Homo
sapiens)		5 / 12ALA A  23
ILE A  26
PHE A  77
MET A  81
LEU A  48
None
None
9XG  A 201 (-3.8A)
9XG  A 201 ( 4.6A)
9XG  A 201 ( 4.8A)
1.19A65.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		5wcj METHYLTRANSFERASE-LI
KE PROTEIN 13
(Homo
sapiens)		5 / 12ALA A 479
PHE A 651
LEU A 507
LEU A 676
PHE A 515
None
1.11A22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		5xix ASPARAGINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens)		5 / 12ILE A 472
PHE A 523
PHE A 256
PHE A 388
LEU A 436
None
1.20A14.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		1ggz CALMODULIN-RELATED
PROTEIN NB-1
(Homo
sapiens)		4 / 8MET A  36
GLN A  41
PRO A  43
GLU A  47
None
0.64A43.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		1now BETA-HEXOSAMINIDASE
BETA CHAIN
(Homo
sapiens)		4 / 8PRO A  58
GLU A 511
ARG A 533
MET A 536
None
1.18A15.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		1w7j MYOSIN LIGHT CHAIN 1
(Homo
sapiens)		4 / 8MET B  36
GLN B  41
PRO B  43
GLU B  47
None
0.70A38.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		1wrk TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES
(Homo
sapiens)		4 / 8MET A  45
GLN A  50
PRO A  52
GLU A  56
TFP  A 202 (-3.6A)
TFP  A 202 (-3.4A)
None
TFP  A 202 ( 4.6A)
0.40A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		1x9n DNA LIGASE I
(Homo
sapiens)		4 / 8GLN A 886
PRO A 884
GLU A 880
ASP A 881
None
1.19A13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		2cqi NUCLEOLYSIN TIAR
(Homo
sapiens)		4 / 8GLN A   7
PRO A   8
GLU A   3
ASP A   4
None
1.13A22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		2lw9 UNCONVENTIONNAL
MYOSIN-X
(Homo
sapiens)		4 / 8GLU A  14
ASP A  17
ARG A  20
MET A  21
None
0.67A18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		3lhr ZINC FINGER PROTEIN
24
(Homo
sapiens)		4 / 8PRO A  74
GLU A  79
GLU A  85
ASP A  86
None
0.97A21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		3rk6 POLYADENYLATE-BINDIN
G
PROTEIN-INTERACTING
PROTEIN 1
(Homo
sapiens)		4 / 8GLN A 218
GLU A 257
GLU A 252
ARG A 222
None
1.16A18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		3um1 BRO1
DOMAIN-CONTAINING
PROTEIN BROX
(Homo
sapiens)		4 / 8GLN A  69
PRO A 359
GLU A 110
ARG A  85
None
1.10A18.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		4gow CALMODULIN
(Homo
sapiens)		4 / 8MET D  36
GLN D  41
PRO D  43
GLU D  47
MET  D  36 ( 0.0A)
GLN  D  41 ( 0.6A)
PRO  D  43 ( 1.1A)
GLU  D  47 ( 0.5A)
1.06A53.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		4q57 CALMODULIN
(Homo
sapiens)		4 / 8MET A  36
GLN A  41
PRO A  43
GLU A  47
None
0.71A42.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		5coc IMMUNOGLOBULIN
G-BINDING PROTEIN
A,CALMODULIN
(Homo
sapiens;
Staphylococcus
aureus)		4 / 8MET A1037
GLN A1042
PRO A1044
GLU A1048
None
0.91A40.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens)		4 / 8GLN A 318
PRO A 384
GLU A 763
GLU A 950
None
1.12A8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens)		4 / 8MET C 776
ASP C 632
ARG C 688
MET C 689
None
1.10A9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		5h9m E3 UBIQUITIN-PROTEIN
LIGASE SIAH2
(Homo
sapiens)		4 / 8GLN A 257
GLU A 156
ASP A 159
ARG A 164
None
1.11A22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens)		4 / 8MET A 776
ASP A 632
ARG A 688
MET A 689
None
1.06A12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens)		4 / 8MET A 776
PRO A 496
ARG A 688
MET A 689
None
1.19A12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		5w21 KLOTHO
(Homo
sapiens)		4 / 8PRO A 937
GLU A 936
GLU A 882
ASP A 883
None
1.19A16.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		5w88 TROPONIN C, TROPONIN
I
(Homo
sapiens)		4 / 8MET A  45
GLN A  50
PRO A  52
GLU A  56
9XG  A 201 (-2.4A)
None
None
None
0.53A65.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		1ggz CALMODULIN-RELATED
PROTEIN NB-1
(Homo
sapiens)		6 / 12LEU A 105
MET A 109
LEU A 112
MET A 124
ILE A 125
VAL A 136
None
1.07A48.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		1ggz CALMODULIN-RELATED
PROTEIN NB-1
(Homo
sapiens)		7 / 12PHE A  19
ILE A  27
LEU A  32
LEU A  39
MET A  51
GLU A  54
VAL A  63
None
None
None
None
None
None
CA  A 150 ( 4.9A)
0.94A48.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		1ggz CALMODULIN-RELATED
PROTEIN NB-1
(Homo
sapiens)		7 / 12PHE A  19
ILE A  27
LEU A  32
MET A  36
LEU A  39
GLU A  54
VAL A  63
None
None
None
None
None
None
CA  A 150 ( 4.9A)
0.91A48.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		1ggz CALMODULIN-RELATED
PROTEIN NB-1
(Homo
sapiens)		6 / 12PHE A  92
LEU A 105
LEU A 112
MET A 124
ILE A 125
VAL A 136
None
0.81A48.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		1m39 CALTRACTIN, ISOFORM
1
(Homo
sapiens)		6 / 12PHE A 113
ILE A 121
LEU A 126
LEU A 133
ILE A 146
VAL A 157
None
1.13A44.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		1wrk TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES
(Homo
sapiens)		7 / 12ILE A  36
LEU A  41
MET A  45
ILE A  61
GLU A  63
VAL A  72
MET A  81
None
None
TFP  A 202 (-3.6A)
None
None
None
TFP  A 202 ( 3.3A)
0.91A97.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		1wrk TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES
(Homo
sapiens)		7 / 12ILE A  36
LEU A  41
MET A  60
ILE A  61
GLU A  63
VAL A  72
MET A  81
None
None
TFP  A 202 ( 4.0A)
None
None
None
TFP  A 202 ( 3.3A)
0.85A97.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		1wrk TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES
(Homo
sapiens)		7 / 12ILE A  36
LEU A  48
MET A  60
ILE A  61
GLU A  63
VAL A  72
MET A  81
None
TFP  A 202 (-4.1A)
TFP  A 202 ( 4.0A)
None
None
None
TFP  A 202 ( 3.3A)
0.86A97.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		1wrk TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES
(Homo
sapiens)		7 / 12ILE A  36
MET A  45
LEU A  48
ILE A  61
GLU A  63
VAL A  72
MET A  81
None
TFP  A 202 (-3.6A)
TFP  A 202 (-4.1A)
None
None
None
TFP  A 202 ( 3.3A)
0.92A97.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		1zot CALMODULIN
(Homo
sapiens)		8 / 12ILE B 100
LEU B 105
MET B 109
LEU B 112
GLU B 127
VAL B 136
MET B 144
MET B 145
None
None
None
None
None
CA  B 800 ( 4.9A)
None
None
1.06A38.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		1zot CALMODULIN
(Homo
sapiens)		9 / 12PHE B  92
ILE B 100
LEU B 105
MET B 109
LEU B 112
ILE B 125
GLU B 127
VAL B 136
MET B 145
None
None
None
None
None
None
None
CA  B 800 ( 4.9A)
None
1.11A38.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		1zot CALMODULIN
(Homo
sapiens)		9 / 12PHE B  92
ILE B 100
LEU B 105
MET B 109
LEU B 112
MET B 124
ILE B 125
VAL B 136
MET B 145
None
None
None
None
None
None
None
CA  B 800 ( 4.9A)
None
1.17A38.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		1zot CALMODULIN
(Homo
sapiens)		7 / 12PHE B  92
ILE B 100
LEU B 105
MET B 124
ILE B 125
VAL B 136
MET B 144
None
None
None
None
None
CA  B 800 ( 4.9A)
None
1.16A38.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		2b1u CALMODULIN-LIKE
PROTEIN 5
(Homo
sapiens)		6 / 12LEU A 103
MET A 107
LEU A 110
MET A 122
GLU A 125
VAL A 134
None
1.19A35.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		2ggm CENTRIN-2
(Homo
sapiens)		6 / 12ILE A 121
LEU A 133
MET A 145
ILE A 146
GLU A 148
VAL A 157
None
0.92A29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		2ggm CENTRIN-2
(Homo
sapiens)		6 / 12ILE A 121
MET A 145
ILE A 146
GLU A 148
VAL A 157
MET A 166
None
0.94A29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		2ggm CENTRIN-2
(Homo
sapiens)		7 / 12PHE A 113
ILE A 121
LEU A 126
MET A 145
ILE A 146
VAL A 157
MET A 166
None
0.97A29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		2jjz IONIZED
CALCIUM-BINDING
ADAPTER MOLECULE 2
(Homo
sapiens)		6 / 12ILE B  67
LEU B  72
MET B  76
LEU B  79
ILE B  92
MET B 111
None
1.08A25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		2jjz IONIZED
CALCIUM-BINDING
ADAPTER MOLECULE 2
(Homo
sapiens)		7 / 12ILE B  67
LEU B  72
MET B  76
LEU B  79
MET B  91
ILE B  92
GLU B  94
None
0.94A25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		2jjz IONIZED
CALCIUM-BINDING
ADAPTER MOLECULE 2
(Homo
sapiens)		6 / 12PHE B  59
ILE B  67
LEU B  72
MET B  76
ILE B  92
MET B 111
None
1.11A25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		2jjz IONIZED
CALCIUM-BINDING
ADAPTER MOLECULE 2
(Homo
sapiens)		7 / 12PHE B  59
ILE B  67
LEU B  72
MET B  76
MET B  91
ILE B  92
GLU B  94
None
0.99A25.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		2k2i CENTRIN-2
(Homo
sapiens)		6 / 12PHE A 113
ILE A 121
LEU A 126
GLU A 148
VAL A 157
MET A 166
None
0.97A44.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		2k2i CENTRIN-2
(Homo
sapiens)		6 / 12PHE A 113
ILE A 121
LEU A 126
ILE A 146
GLU A 148
VAL A 157
None
0.90A44.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		2k7d CALCIUM-BINDING
PROTEIN 1
(Homo
sapiens)		6 / 12ILE A 119
LEU A 124
MET A 128
LEU A 131
VAL A 156
MET A 165
None
1.14A39.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		2lv7 CALCIUM-BINDING
PROTEIN 7
(Homo
sapiens)		6 / 12PHE A  42
ILE A  53
LEU A  58
LEU A  65
ILE A  78
VAL A  89
None
None
None
None
None
CA  A 202 ( 4.2A)
1.07A34.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		2n6a HUMAN
CALMODULIN/CONNEXIN-
36 PEPTIDE HYBRID
(Homo
sapiens)		8 / 12PHE A  92
ILE A 100
LEU A 105
MET A 109
MET A 124
ILE A 125
VAL A 136
MET A 144
None
1.16A57.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		2obh CENTRIN-2
(Homo
sapiens)		6 / 12ILE A 121
LEU A 133
MET A 145
ILE A 146
GLU A 148
VAL A 157
None
None
None
None
None
CA  A1001 ( 4.9A)
1.05A31.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		4gow CALMODULIN
(Homo
sapiens)		7 / 12ILE D 100
LEU D 105
MET D 109
MET D 124
ILE D 125
VAL D 136
MET D 145
ILE  D 100 ( 0.7A)
LEU  D 105 ( 0.6A)
MET  D 109 ( 0.0A)
MET  D 124 ( 0.0A)
ILE  D 125 ( 0.4A)
VAL  D 136 ( 0.6A)
MET  D 145 ( 0.0A)
1.07A67.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		4gow CALMODULIN
(Homo
sapiens)		7 / 12LEU D 105
MET D 109
MET D 124
ILE D 125
VAL D 136
MET D 144
MET D 145
LEU  D 105 ( 0.6A)
MET  D 109 ( 0.0A)
MET  D 124 ( 0.0A)
ILE  D 125 ( 0.4A)
VAL  D 136 ( 0.6A)
MET  D 144 ( 0.0A)
MET  D 145 ( 0.0A)
1.31A67.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		4gow CALMODULIN
(Homo
sapiens)		7 / 12PHE D  92
ILE D 100
LEU D 105
MET D 124
ILE D 125
VAL D 136
MET D 145
PHE  D  92 ( 1.3A)
ILE  D 100 ( 0.7A)
LEU  D 105 ( 0.6A)
MET  D 124 ( 0.0A)
ILE  D 125 ( 0.4A)
VAL  D 136 ( 0.6A)
MET  D 145 ( 0.0A)
0.78A67.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		4gow CALMODULIN
(Homo
sapiens)		6 / 12PHE D  92
LEU D 105
MET D 124
ILE D 125
GLU D 127
VAL D 136
PHE  D  92 ( 1.3A)
LEU  D 105 ( 0.6A)
MET  D 124 ( 0.0A)
ILE  D 125 ( 0.4A)
GLU  D 127 ( 0.6A)
VAL  D 136 ( 0.6A)
0.94A67.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		4q57 CALMODULIN
(Homo
sapiens)		6 / 12PHE A  19
ILE A  27
LEU A  32
MET A  36
ILE A  52
GLU A  54
None
0.85A55.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		5coc IMMUNOGLOBULIN
G-BINDING PROTEIN
A,CALMODULIN
(Homo
sapiens;
Staphylococcus
aureus)		7 / 12PHE A1020
ILE A1028
LEU A1033
MET A1037
MET A1052
ILE A1053
GLU A1055
None
1.08A40.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		5i2q EF-HAND
DOMAIN-CONTAINING
PROTEIN D2
(Homo
sapiens)		6 / 12ILE A 112
LEU A 117
MET A 121
LEU A 124
MET A 136
ILE A 137
None
1.13A28.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		5w88 TROPONIN C, TROPONIN
I
(Homo
sapiens)		9 / 12PHE A  27
ILE A  36
LEU A  41
MET A  45
LEU A  48
MET A  60
ILE A  61
GLU A  63
VAL A  72
9XG  A 201 (-3.8A)
9XG  A 201 ( 3.3A)
9XG  A 201 (-3.9A)
9XG  A 201 (-2.4A)
9XG  A 201 ( 4.8A)
9XG  A 201 (-4.0A)
9XG  A 201 ( 4.0A)
None
9XG  A 201 (-3.8A)
0.84A97.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		5w88 TROPONIN C, TROPONIN
I
(Homo
sapiens)		6 / 12PHE A  27
LEU A  41
MET A  45
LEU A  48
GLU A  63
MET A  80
9XG  A 201 (-3.8A)
9XG  A 201 (-3.9A)
9XG  A 201 (-2.4A)
9XG  A 201 ( 4.8A)
None
9XG  A 201 (-4.0A)
1.00A97.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		5wea PROTEIN ARGONAUTE-2
(Homo
sapiens)		6 / 12PHE A 666
ILE A 687
LEU A 642
MET A 645
GLU A 648
CYH A 626
None
1.14A20.22