POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_0
(NEURAMINIDASE)		4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens)		5 / 12GLU B 189
ARG B 262
ILE B 141
ARG B 143
GLU B 178
None
1.34A21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_0
(NEURAMINIDASE)		4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens)		5 / 12LEU A 950
ARG A 946
GLU A 949
GLU A 807
TYR A 961
None
1.33A20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_0
(NEURAMINIDASE)		5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens)		5 / 12GLU A 434
ARG A 509
ILE A 386
ARG A 388
GLU A 423
None
1.32A21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens)		3 / 3ARG A 337
ARG A 446
ARG A 524
XMP  A1694 (-4.2A)
None
None
0.88A20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		3edy TRIPEPTIDYL-PEPTIDAS
E 1
(Homo
sapiens)		3 / 3ARG A 375
ARG A 371
ARG A  28
None
EDO  A 703 ( 4.6A)
None
1.02A19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		4mob ACYL-COENZYME A
THIOESTERASE 12
(Homo
sapiens)		3 / 3ARG A 313
ARG A 179
ARG A 312
ADP  A 402 (-3.4A)
None
ADP  A 402 (-3.7A)
1.03A20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		4s0v HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi)		3 / 3ARG A 152
ARG A 168
ARG A 299
None
0.94A20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		4ykn PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT
ALPHA,PHOSPHATIDYLIN
OSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM FUSION
PROTEIN
(Homo
sapiens)		3 / 3ARG A1088
ARG A1704
ARG A1038
None
1.05A13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7G_A_BCZA801_0
(NEURAMINIDASE)		4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens)		5 / 12LEU A 950
ARG A 946
GLU A 949
GLU A 807
TYR A 961
None
1.33A20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_0
(NEURAMINIDASE)		4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens)		5 / 12GLU B 189
ARG B 262
ILE B 141
ARG B 143
GLU B 178
None
1.32A21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_0
(NEURAMINIDASE)		4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens)		5 / 12LEU A 950
ARG A 946
GLU A 949
GLU A 807
TYR A 961
None
1.34A20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_0
(NEURAMINIDASE)		5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens)		5 / 12GLU B 290
LEU B 286
ARG B 664
ARG B 297
TYR B 486
None
1.49A17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_0
(NEURAMINIDASE)		5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens)		5 / 12GLU A 434
ARG A 509
ILE A 386
ARG A 388
GLU A 423
None
1.32A21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens)		3 / 3ARG A 337
ARG A 446
ARG A 524
XMP  A1694 (-4.2A)
None
None
0.89A20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		3edy TRIPEPTIDYL-PEPTIDAS
E 1
(Homo
sapiens)		3 / 3ARG A 375
ARG A 371
ARG A  28
None
EDO  A 703 ( 4.6A)
None
1.01A19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		4mob ACYL-COENZYME A
THIOESTERASE 12
(Homo
sapiens)		3 / 3ARG A 313
ARG A 179
ARG A 312
ADP  A 402 (-3.4A)
None
ADP  A 402 (-3.7A)
1.06A20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		4s0v HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi)		3 / 3ARG A 152
ARG A 168
ARG A 299
None
0.95A20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		4ykn PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT
ALPHA,PHOSPHATIDYLIN
OSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM FUSION
PROTEIN
(Homo
sapiens)		3 / 3ARG A1088
ARG A1704
ARG A1038
None
1.05A13.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2F10_A_BCZA382_0
(SIALIDASE 2)		2f28 SIALIDASE 2
(Homo
sapiens)		11 / 12ARG A  21
ILE A  22
GLU A  39
MET A  85
ASN A  86
TYR A 179
LEU A 217
GLU A 218
ARG A 237
ARG A 304
TYR A 334
None
0.46A99.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F10_A_BCZA382_0
(SIALIDASE 2)		5dsy POLY [ADP-RIBOSE]
POLYMERASE 2
(Homo
sapiens)		5 / 12GLU A 476
ARG A 555
ASN A 519
GLU A 365
TYR A 558
None
1.46A22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HTU_A_BCZA801_0
(NEURAMINIDASE)		5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4
(Homo
sapiens)		5 / 12LEU A 152
SER A 149
ILE A 102
ARG A 179
TYR A 181
None
None
None
None
EDO  A 606 (-4.6A)
1.45Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_0
(NEURAMINIDASE)		2a30 DEOXYCYTIDINE KINASE
(Homo
sapiens)		5 / 12ARG A 128
LEU A 208
GLU A 196
GLU A 197
ARG A 194
DCZ  A 302 (-4.1A)
None
None
DCZ  A 302 (-3.5A)
DCZ  A 302 ( 4.8A)
1.36A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_0
(NEURAMINIDASE)		2lz1 NUCLEAR FACTOR
ERYTHROID 2-RELATED
FACTOR 2
(Homo
sapiens)		5 / 12ARG A  16
GLU A  18
LEU A  17
ARG A  84
ALA A  28
None
1.10A16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_0
(NEURAMINIDASE)		2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens)		5 / 12GLU A 482
ARG A 495
ARG A 490
ALA A 459
GLU A 486
None
0.82A20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_0
(NEURAMINIDASE)		4mel UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 11
(Homo
sapiens)		5 / 12GLU A  71
GLU A  50
GLU A  43
ARG A  49
TYR A  67
None
1.46A20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_0
(NEURAMINIDASE)		4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens)		5 / 12LEU A 950
ARG A 946
GLU A 949
GLU A 807
TYR A 961
None
1.36A21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_0
(NEURAMINIDASE)		5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens)		5 / 12GLU A 434
ARG A 509
ARG A 388
ALA A 412
GLU A 423
None
1.37A20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		1itu RENAL DIPEPTIDASE
(Homo
sapiens)		3 / 3ASP A 235
ARG A 238
ARG A 229
None
0.97A20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		1zef ALKALINE PHOSPHATASE
(Homo
sapiens)		3 / 3ASP A 273
ARG A 314
ARG A 166
None
None
SEP  A  92 (-2.9A)
1.01A22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		2bv5 TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 5
(Homo
sapiens)		3 / 3ASP A 358
ARG A 361
ARG A 300
None
1.03A21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		2ydy METHIONINE
ADENOSYLTRANSFERASE
2 SUBUNIT BETA
(Homo
sapiens)		3 / 3ASP A 296
ARG A 148
ARG A 308
None
0.89A21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		3e0j DNA POLYMERASE
SUBUNIT DELTA-2
(Homo
sapiens)		3 / 3ASP A 193
ARG A 443
ARG A   9
None
0.96A21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		3gzd SELENOCYSTEINE LYASE
(Homo
sapiens)		3 / 3ASP C 244
ARG C 242
ARG C 271
None
0.90A20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN
(Homo
sapiens)		3 / 3ASP B 236
ARG B 242
ARG B 217
None
0.90A21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		4qkf ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB
HOMOLOG 7,
MITOCHONDRIAL
(Homo
sapiens)		3 / 3ASP A 111
ARG A  74
ARG A 194
None
1.03A19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		4v2d FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 2
(Homo
sapiens)		3 / 3ASP A 212
ARG A 239
ARG A 208
None
0.98A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens)		3 / 3ASP B3995
ARG B3998
ARG B3963
None
1.00A21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		5tws HUMAN DNA POLYMERASE
MU
(Homo
sapiens)		3 / 3ASP A 330
ARG A 416
ARG A 323
 MG  A 501 (-2.6A)
NA  A 502 ( 4.9A)
GOA  A 503 (-3.0A)
1.01A20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		6bsz METABOTROPIC
GLUTAMATE RECEPTOR 8
(Homo
sapiens)		3 / 3ASP A 342
ARG A 346
ARG A 335
None
0.60Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_0
(NEURAMINIDASE)		2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens)		5 / 12GLU A 128
ARG A 358
ALA A 346
GLU A 129
ARG A 136
None
1.43A22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_0
(NEURAMINIDASE)		2lz1 NUCLEAR FACTOR
ERYTHROID 2-RELATED
FACTOR 2
(Homo
sapiens)		5 / 12ARG A  16
GLU A  18
LEU A  17
ARG A  84
ALA A  28
None
1.11A16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_0
(NEURAMINIDASE)		6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens)		5 / 12ARG A 481
LEU A 310
ARG A 315
ALA A 423
ARG A 422
None
1.50Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		2c4k PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens)		3 / 3ARG A 169
GLU A 164
TYR A 281
None
0.88A22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		2dj0 THIOREDOXIN-RELATED
TRANSMEMBRANE
PROTEIN 2
(Homo
sapiens)		3 / 3ARG A 124
GLU A 130
TYR A  55
None
0.94A15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		2kny LRP-1, LINKER, APO-E
(Homo
sapiens)		3 / 3ARG A  24
GLU A  39
TYR A  47
None
CA  A  81 (-2.8A)
None
0.89A11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens)		3 / 3ARG B 732
GLU B 707
TYR B 589
None
0.85A16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		2okj GLUTAMATE
DECARBOXYLASE 1
(Homo
sapiens)		3 / 3ARG A 186
GLU A 585
TYR A 489
None
0.88A20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		2okk GLUTAMATE
DECARBOXYLASE 2
(Homo
sapiens)		3 / 3ARG A 177
GLU A 576
TYR A 480
None
0.93A21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		3 / 3ARG A  73
GLU A  67
TYR A  96
GRG  A 500 (-2.9A)
None
None
0.88A19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		2xwb COMPLEMENT FACTOR B
(Homo
sapiens)		3 / 3ARG F 113
GLU F  85
TYR F 164
None
0.82A19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		3l2p DNA LIGASE 3
(Homo
sapiens)		3 / 3ARG A 527
GLU A 536
TYR A 422
None
None
AMP  A 901 (-4.6A)
0.88A20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3
(Homo
sapiens)		3 / 3ARG A 257
GLU A 289
TYR A 455
None
0.95A19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE
(Homo
sapiens)		3 / 3ARG B 558
GLU B 550
TYR B 540
None
0.86A12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		4pz3 CD44 ANTIGEN
(Homo
sapiens)		3 / 3ARG A 150
GLU A  37
TYR A 117
None
PEG  A 201 (-2.6A)
None
0.81A16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		4qhk UCA HEAVY CHAIN
(Homo
sapiens)		3 / 3ARG M  66
GLU M  46
TYR M  90
None
0.89A20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		5j7t UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens)		3 / 3ARG A 301
GLU A 345
TYR A 367
None
0.94A18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens)		3 / 3ARG A 131
GLU A 395
TYR A 164
None
0.75A19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		5xgj PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM
(Homo
sapiens)		3 / 3ARG A1023
GLU A 950
TYR A 988
None
0.79Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_A_BCZA1001_0
(NEURAMINIDASE)		1fta FRUCTOSE-1,6-BISPHOS
PHATASE
(Homo
sapiens)		5 / 12ARG A 313
LEU A 275
GLU A 280
GLU A  98
GLU A  97
None
1.48A22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_A_BCZA1001_0
(NEURAMINIDASE)		2a30 DEOXYCYTIDINE KINASE
(Homo
sapiens)		5 / 12ARG A 128
LEU A 208
GLU A 196
GLU A 197
ARG A 194
DCZ  A 302 (-4.1A)
None
None
DCZ  A 302 (-3.5A)
DCZ  A 302 ( 4.8A)
1.35A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_A_BCZA1001_0
(NEURAMINIDASE)		2lz1 NUCLEAR FACTOR
ERYTHROID 2-RELATED
FACTOR 2
(Homo
sapiens)		5 / 12ARG A  16
GLU A  18
LEU A  17
ARG A  84
ALA A  28
None
1.18A16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_A_BCZA1001_0
(NEURAMINIDASE)		2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens)		5 / 12GLU A 482
ARG A 495
ARG A 490
ALA A 459
GLU A 486
None
0.95A21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_A_BCZA1001_0
(NEURAMINIDASE)		4mel UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 11
(Homo
sapiens)		5 / 12GLU A  71
GLU A  50
GLU A  43
ARG A  49
TYR A  67
None
1.48A20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_A_BCZA1001_0
(NEURAMINIDASE)		5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens)		5 / 12GLU A 434
ARG A 509
ARG A 388
ALA A 412
GLU A 423
None
1.34A20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_B_BCZB1001_0
(NEURAMINIDASE)		2lz1 NUCLEAR FACTOR
ERYTHROID 2-RELATED
FACTOR 2
(Homo
sapiens)		5 / 12ARG A  16
GLU A  18
LEU A  17
ARG A  84
ALA A  28
None
1.18A16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_C_BCZC1001_0
(NEURAMINIDASE)		1fta FRUCTOSE-1,6-BISPHOS
PHATASE
(Homo
sapiens)		5 / 12ARG A 313
LEU A 275
GLU A 280
GLU A  98
GLU A  97
None
1.48A22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_C_BCZC1001_0
(NEURAMINIDASE)		2a30 DEOXYCYTIDINE KINASE
(Homo
sapiens)		5 / 12ARG A 128
LEU A 208
GLU A 196
GLU A 197
ARG A 194
DCZ  A 302 (-4.1A)
None
None
DCZ  A 302 (-3.5A)
DCZ  A 302 ( 4.8A)
1.34A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_C_BCZC1001_0
(NEURAMINIDASE)		2lz1 NUCLEAR FACTOR
ERYTHROID 2-RELATED
FACTOR 2
(Homo
sapiens)		5 / 12ARG A  16
GLU A  18
LEU A  17
ARG A  84
ALA A  28
None
1.19A16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_C_BCZC1001_0
(NEURAMINIDASE)		2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens)		5 / 12GLU A 482
ARG A 495
ARG A 490
ALA A 459
GLU A 486
None
0.96A21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_C_BCZC1001_0
(NEURAMINIDASE)		3a7s UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5
(Homo
sapiens)		5 / 12ARG A  73
LEU A  74
ARG A 182
ALA A  65
GLU A 177
None
1.46A18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_C_BCZC1001_0
(NEURAMINIDASE)		5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens)		5 / 12ARG A 929
ASP A 914
ARG A 814
GLU A1034
ARG A1039
None
None
EDO  A1603 (-3.9A)
EDO  A1603 (-2.7A)
EDO  A1603 ( 3.8A)
1.36A13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_C_BCZC1001_0
(NEURAMINIDASE)		5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens)		5 / 12GLU A 434
ARG A 509
ARG A 388
ALA A 412
GLU A 423
None
1.35A20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_D_BCZD1001_0
(NEURAMINIDASE)		2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens)		5 / 12GLU A 128
ARG A 358
ALA A 346
GLU A 129
ARG A 136
None
1.49A22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_D_BCZD1001_0
(NEURAMINIDASE)		2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens)		5 / 12GLU A 482
ARG A 495
ARG A 490
ALA A 459
GLU A 486
None
0.95A21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_D_BCZD1001_0
(NEURAMINIDASE)		3kn1 GOLGI PHOSPHOPROTEIN
3
(Homo
sapiens)		5 / 12GLU A  64
LEU A 181
ALA A 238
ARG A 235
ARG A 100
None
None
None
SO4  A   4 (-4.5A)
SO4  A   3 (-4.5A)
1.40A19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_D_BCZD1001_0
(NEURAMINIDASE)		4p2k EPHRIN TYPE-A
RECEPTOR 2
(Homo
sapiens)		5 / 12ASP A 799
ARG A 861
ALA A 785
GLU A 787
ARG A 762
None
1.38A21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_D_BCZD1001_0
(NEURAMINIDASE)		5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens)		5 / 12GLU A 434
ARG A 509
ARG A 388
ALA A 412
GLU A 423
None
1.33A20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_E_BCZE1001_0
(NEURAMINIDASE)		1fta FRUCTOSE-1,6-BISPHOS
PHATASE
(Homo
sapiens)		5 / 12ARG A 313
LEU A 275
GLU A 280
GLU A  98
GLU A  97
None
1.47A22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_E_BCZE1001_0
(NEURAMINIDASE)		2a30 DEOXYCYTIDINE KINASE
(Homo
sapiens)		5 / 12ARG A 128
LEU A 208
GLU A 196
GLU A 197
ARG A 194
DCZ  A 302 (-4.1A)
None
None
DCZ  A 302 (-3.5A)
DCZ  A 302 ( 4.8A)
1.34A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_E_BCZE1001_0
(NEURAMINIDASE)		2lz1 NUCLEAR FACTOR
ERYTHROID 2-RELATED
FACTOR 2
(Homo
sapiens)		5 / 12ARG A  16
GLU A  18
LEU A  17
ARG A  84
ALA A  28
None
1.17A16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_E_BCZE1001_0
(NEURAMINIDASE)		2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens)		5 / 12GLU A 482
ARG A 495
ARG A 490
ALA A 459
GLU A 486
None
0.95A21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_E_BCZE1001_0
(NEURAMINIDASE)		4mel UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 11
(Homo
sapiens)		5 / 12GLU A  71
GLU A  50
GLU A  43
ARG A  49
TYR A  67
None
1.45A20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_E_BCZE1001_0
(NEURAMINIDASE)		5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens)		5 / 12GLU A 434
ARG A 509
ARG A 388
ALA A 412
GLU A 423
None
1.34A20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_F_BCZF1001_0
(NEURAMINIDASE)		2a30 DEOXYCYTIDINE KINASE
(Homo
sapiens)		5 / 12ARG A 128
LEU A 208
GLU A 196
GLU A 197
ARG A 194
DCZ  A 302 (-4.1A)
None
None
DCZ  A 302 (-3.5A)
DCZ  A 302 ( 4.8A)
1.34A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_F_BCZF1001_0
(NEURAMINIDASE)		2lz1 NUCLEAR FACTOR
ERYTHROID 2-RELATED
FACTOR 2
(Homo
sapiens)		5 / 12ARG A  16
GLU A  18
LEU A  17
ARG A  84
ALA A  28
None
1.17A16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_F_BCZF1001_0
(NEURAMINIDASE)		2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens)		5 / 12GLU A 482
ARG A 495
ARG A 490
ALA A 459
GLU A 486
None
0.94A21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_F_BCZF1001_0
(NEURAMINIDASE)		4mel UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 11
(Homo
sapiens)		5 / 12GLU A  71
GLU A  50
GLU A  43
ARG A  49
TYR A  67
None
1.45A20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_F_BCZF1001_0
(NEURAMINIDASE)		5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens)		5 / 12GLU A 434
ARG A 509
ARG A 388
ALA A 412
GLU A 423
None
1.34A20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_G_BCZG1001_0
(NEURAMINIDASE)		1fta FRUCTOSE-1,6-BISPHOS
PHATASE
(Homo
sapiens)		5 / 12ARG A 313
LEU A 275
GLU A 280
GLU A  98
GLU A  97
None
1.47A22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_G_BCZG1001_0
(NEURAMINIDASE)		2a30 DEOXYCYTIDINE KINASE
(Homo
sapiens)		5 / 12ARG A 128
LEU A 208
GLU A 196
GLU A 197
ARG A 194
DCZ  A 302 (-4.1A)
None
None
DCZ  A 302 (-3.5A)
DCZ  A 302 ( 4.8A)
1.35A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_G_BCZG1001_0
(NEURAMINIDASE)		2lz1 NUCLEAR FACTOR
ERYTHROID 2-RELATED
FACTOR 2
(Homo
sapiens)		5 / 12ARG A  16
GLU A  18
LEU A  17
ARG A  84
ALA A  28
None
1.17A16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_G_BCZG1001_0
(NEURAMINIDASE)		2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens)		5 / 12GLU A 482
ARG A 495
ARG A 490
ALA A 459
GLU A 486
None
0.95A21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_G_BCZG1001_0
(NEURAMINIDASE)		4mel UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 11
(Homo
sapiens)		5 / 12GLU A  71
GLU A  50
GLU A  43
ARG A  49
TYR A  67
None
1.45A20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_G_BCZG1001_0
(NEURAMINIDASE)		5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens)		5 / 12GLU A 434
ARG A 509
ARG A 388
ALA A 412
GLU A 423
None
1.33A20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_H_BCZH1001_0
(NEURAMINIDASE)		1fta FRUCTOSE-1,6-BISPHOS
PHATASE
(Homo
sapiens)		5 / 12ARG A 313
LEU A 275
GLU A 280
GLU A  98
GLU A  97
None
1.47A22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_H_BCZH1001_0
(NEURAMINIDASE)		2a30 DEOXYCYTIDINE KINASE
(Homo
sapiens)		5 / 12ARG A 128
LEU A 208
GLU A 196
GLU A 197
ARG A 194
DCZ  A 302 (-4.1A)
None
None
DCZ  A 302 (-3.5A)
DCZ  A 302 ( 4.8A)
1.34A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_H_BCZH1001_0
(NEURAMINIDASE)		2lz1 NUCLEAR FACTOR
ERYTHROID 2-RELATED
FACTOR 2
(Homo
sapiens)		5 / 12ARG A  16
GLU A  18
LEU A  17
ARG A  84
ALA A  28
None
1.18A16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_H_BCZH1001_0
(NEURAMINIDASE)		2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens)		5 / 12GLU A 482
ARG A 495
ARG A 490
ALA A 459
GLU A 486
None
0.95A21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_H_BCZH1001_0
(NEURAMINIDASE)		4mel UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 11
(Homo
sapiens)		5 / 12GLU A  71
GLU A  50
GLU A  43
ARG A  49
TYR A  67
None
1.46A20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_H_BCZH1001_0
(NEURAMINIDASE)		5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens)		5 / 12GLU A 434
ARG A 509
ARG A 388
ALA A 412
GLU A 423
None
1.33A20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_I_BCZI1001_0
(NEURAMINIDASE)		2a30 DEOXYCYTIDINE KINASE
(Homo
sapiens)		5 / 12ARG A 128
LEU A 208
GLU A 196
GLU A 197
ARG A 194
DCZ  A 302 (-4.1A)
None
None
DCZ  A 302 (-3.5A)
DCZ  A 302 ( 4.8A)
1.35A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_I_BCZI1001_0
(NEURAMINIDASE)		2lz1 NUCLEAR FACTOR
ERYTHROID 2-RELATED
FACTOR 2
(Homo
sapiens)		5 / 12ARG A  16
GLU A  18
LEU A  17
ARG A  84
ALA A  28
None
1.18A16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_I_BCZI1001_0
(NEURAMINIDASE)		2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens)		5 / 12GLU A 482
ARG A 495
ARG A 490
ALA A 459
GLU A 486
None
0.95A21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_I_BCZI1001_0
(NEURAMINIDASE)		3a7s UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5
(Homo
sapiens)		5 / 12ARG A  73
LEU A  74
ARG A 182
ALA A  65
GLU A 177
None
1.47A18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_I_BCZI1001_0
(NEURAMINIDASE)		5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens)		5 / 12ARG A 929
ASP A 914
ARG A 814
GLU A1034
ARG A1039
None
None
EDO  A1603 (-3.9A)
EDO  A1603 (-2.7A)
EDO  A1603 ( 3.8A)
1.34A13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_I_BCZI1001_0
(NEURAMINIDASE)		5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens)		5 / 12GLU A 434
ARG A 509
ARG A 388
ALA A 412
GLU A 423
None
1.34A20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_J_BCZJ1001_0
(NEURAMINIDASE)		2a30 DEOXYCYTIDINE KINASE
(Homo
sapiens)		5 / 12ARG A 128
LEU A 208
GLU A 196
GLU A 197
ARG A 194
DCZ  A 302 (-4.1A)
None
None
DCZ  A 302 (-3.5A)
DCZ  A 302 ( 4.8A)
1.36A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_J_BCZJ1001_0
(NEURAMINIDASE)		2lz1 NUCLEAR FACTOR
ERYTHROID 2-RELATED
FACTOR 2
(Homo
sapiens)		5 / 12ARG A  16
GLU A  18
LEU A  17
ARG A  84
ALA A  28
None
1.17A16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_J_BCZJ1001_0
(NEURAMINIDASE)		2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens)		5 / 12GLU A 482
ARG A 495
ARG A 490
ALA A 459
GLU A 486
None
0.97A21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_J_BCZJ1001_0
(NEURAMINIDASE)		5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens)		5 / 12ARG A 929
ASP A 914
ARG A 814
GLU A1034
ARG A1039
None
None
EDO  A1603 (-3.9A)
EDO  A1603 (-2.7A)
EDO  A1603 ( 3.8A)
1.36A13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_J_BCZJ1001_0
(NEURAMINIDASE)		5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens)		5 / 12GLU A 434
ARG A 509
ARG A 388
ALA A 412
GLU A 423
None
1.34A20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_K_BCZK1001_0
(NEURAMINIDASE)		1fta FRUCTOSE-1,6-BISPHOS
PHATASE
(Homo
sapiens)		5 / 12ARG A 313
LEU A 275
GLU A 280
GLU A  98
GLU A  97
None
1.47A22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_K_BCZK1001_0
(NEURAMINIDASE)		2a30 DEOXYCYTIDINE KINASE
(Homo
sapiens)		5 / 12ARG A 128
LEU A 208
GLU A 196
GLU A 197
ARG A 194
DCZ  A 302 (-4.1A)
None
None
DCZ  A 302 (-3.5A)
DCZ  A 302 ( 4.8A)
1.35A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_K_BCZK1001_0
(NEURAMINIDASE)		2lz1 NUCLEAR FACTOR
ERYTHROID 2-RELATED
FACTOR 2
(Homo
sapiens)		5 / 12ARG A  16
GLU A  18
LEU A  17
ARG A  84
ALA A  28
None
1.17A16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_K_BCZK1001_0
(NEURAMINIDASE)		2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens)		5 / 12GLU A 482
ARG A 495
ARG A 490
ALA A 459
GLU A 486
None
0.94A21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_K_BCZK1001_0
(NEURAMINIDASE)		5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens)		5 / 12ARG A 929
ASP A 914
ARG A 814
GLU A1034
ARG A1039
None
None
EDO  A1603 (-3.9A)
EDO  A1603 (-2.7A)
EDO  A1603 ( 3.8A)
1.35A13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_K_BCZK1001_0
(NEURAMINIDASE)		5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens)		5 / 12GLU A 434
ARG A 509
ARG A 388
ALA A 412
GLU A 423
None
1.34A20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_L_BCZL1001_0
(NEURAMINIDASE)		1fta FRUCTOSE-1,6-BISPHOS
PHATASE
(Homo
sapiens)		5 / 12ARG A 313
LEU A 275
GLU A 280
GLU A  98
GLU A  97
None
1.49A22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_L_BCZL1001_0
(NEURAMINIDASE)		2a30 DEOXYCYTIDINE KINASE
(Homo
sapiens)		5 / 12ARG A 128
LEU A 208
GLU A 196
GLU A 197
ARG A 194
DCZ  A 302 (-4.1A)
None
None
DCZ  A 302 (-3.5A)
DCZ  A 302 ( 4.8A)
1.36A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_L_BCZL1001_0
(NEURAMINIDASE)		2lz1 NUCLEAR FACTOR
ERYTHROID 2-RELATED
FACTOR 2
(Homo
sapiens)		5 / 12ARG A  16
GLU A  18
LEU A  17
ARG A  84
ALA A  28
None
1.18A16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_L_BCZL1001_0
(NEURAMINIDASE)		2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens)		5 / 12GLU A 482
ARG A 495
ARG A 490
ALA A 459
GLU A 486
None
0.96A21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_L_BCZL1001_0
(NEURAMINIDASE)		5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens)		5 / 12ARG A 929
ASP A 914
ARG A 814
GLU A1034
ARG A1039
None
None
EDO  A1603 (-3.9A)
EDO  A1603 (-2.7A)
EDO  A1603 ( 3.8A)
1.36A13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_L_BCZL1001_0
(NEURAMINIDASE)		5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens)		5 / 12GLU A 434
ARG A 509
ARG A 388
ALA A 412
GLU A 423
None
1.32A20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_M_BCZM1001_0
(NEURAMINIDASE)		2a30 DEOXYCYTIDINE KINASE
(Homo
sapiens)		5 / 12ARG A 128
LEU A 208
GLU A 196
GLU A 197
ARG A 194
DCZ  A 302 (-4.1A)
None
None
DCZ  A 302 (-3.5A)
DCZ  A 302 ( 4.8A)
1.36A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_M_BCZM1001_0
(NEURAMINIDASE)		2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens)		5 / 12GLU A 482
ARG A 495
ARG A 490
ALA A 459
GLU A 486
None
0.96A21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_M_BCZM1001_0
(NEURAMINIDASE)		4mel UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 11
(Homo
sapiens)		5 / 12GLU A  71
GLU A  50
GLU A  43
ARG A  49
TYR A  67
None
1.47A20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_M_BCZM1001_0
(NEURAMINIDASE)		5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens)		5 / 12GLU A 434
ARG A 509
ARG A 388
ALA A 412
GLU A 423
None
1.35A20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_N_BCZN1001_0
(NEURAMINIDASE)		2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens)		5 / 12GLU A 128
ARG A 358
ALA A 346
GLU A 129
ARG A 136
None
1.49A22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_N_BCZN1001_0
(NEURAMINIDASE)		2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens)		5 / 12GLU A 482
ARG A 495
ARG A 490
ALA A 459
GLU A 486
None
0.95A21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_N_BCZN1001_0
(NEURAMINIDASE)		3kn1 GOLGI PHOSPHOPROTEIN
3
(Homo
sapiens)		5 / 12GLU A  64
LEU A 181
ALA A 238
ARG A 235
ARG A 100
None
None
None
SO4  A   4 (-4.5A)
SO4  A   3 (-4.5A)
1.39A19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_N_BCZN1001_0
(NEURAMINIDASE)		4mel UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 11
(Homo
sapiens)		5 / 12GLU A  71
GLU A  50
GLU A  43
ARG A  49
TYR A  67
None
1.45A20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_N_BCZN1001_0
(NEURAMINIDASE)		5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens)		5 / 12GLU A 434
ARG A 509
ARG A 388
ALA A 412
GLU A 423
None
1.33A20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_O_BCZO1001_0
(NEURAMINIDASE)		2f28 SIALIDASE 2
(Homo
sapiens)		5 / 12ARG A 304
GLU A 355
GLU A  39
ARG A 237
TYR A 334
None
1.49A21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_O_BCZO1001_0
(NEURAMINIDASE)		2gf5 FADD PROTEIN
(Homo
sapiens)		5 / 12GLU A  19
LEU A  15
ARG A  71
ARG A  72
GLU A  22
None
1.23A18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_O_BCZO1001_0
(NEURAMINIDASE)		2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens)		5 / 12GLU A 482
ARG A 495
ARG A 490
ALA A 459
GLU A 486
None
0.98A21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_O_BCZO1001_0
(NEURAMINIDASE)		3a7s UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5
(Homo
sapiens)		5 / 12ARG A  73
LEU A  74
ARG A 182
ALA A  65
GLU A 177
None
1.45A18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_O_BCZO1001_0
(NEURAMINIDASE)		5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens)		5 / 12GLU A 434
ARG A 509
ARG A 388
ALA A 412
GLU A 423
None
1.35A20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_P_BCZP1001_0
(NEURAMINIDASE)		2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens)		5 / 12GLU A 482
ARG A 495
ARG A 490
ALA A 459
GLU A 486
None
0.97A21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_P_BCZP1001_0
(NEURAMINIDASE)		3kn1 GOLGI PHOSPHOPROTEIN
3
(Homo
sapiens)		5 / 12GLU A  64
LEU A 181
ALA A 238
ARG A 235
ARG A 100
None
None
None
SO4  A   4 (-4.5A)
SO4  A   3 (-4.5A)
1.41A19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_P_BCZP1001_0
(NEURAMINIDASE)		4mel UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 11
(Homo
sapiens)		5 / 12GLU A  71
GLU A  50
GLU A  43
ARG A  49
TYR A  67
None
1.45A20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_P_BCZP1001_0
(NEURAMINIDASE)		5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens)		5 / 12GLU A 434
ARG A 509
ARG A 388
ALA A 412
GLU A 423
None
1.34A20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_0
(NEURAMINIDASE)		2gf5 FADD PROTEIN
(Homo
sapiens)		5 / 12GLU A  19
LEU A  15
ARG A  71
ARG A  72
GLU A  22
None
1.25A17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_0
(NEURAMINIDASE)		4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens)		5 / 12GLU B 189
ARG B 262
ILE B 141
ARG B 143
GLU B 178
None
1.36A20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_0
(NEURAMINIDASE)		5fwk HSP90 CO-CHAPERONE
CDC37
(Homo
sapiens)		5 / 12GLU E  99
LEU E 102
ARG E 106
GLU E  95
ARG E  92
None
1.45A18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_0
(NEURAMINIDASE)		5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens)		5 / 12GLU A 434
ARG A 509
ILE A 386
ARG A 388
GLU A 423
None
1.32A20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		1fgg GLUCURONYLTRANSFERAS
E I
(Homo
sapiens)		3 / 3ARG A 310
GLU A  92
ARG A 156
UDP  A 337 (-3.6A)
None
UDP  A 337 (-3.1A)
0.95A19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		1siq GLUTARYL-COA
DEHYDROGENASE
(Homo
sapiens)		3 / 3ARG A  34
GLU A  58
ARG A  38
None
0.94A20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		2dba SMOOTH MUSCLE CELL
ASSOCIATED
PROTEIN-1, ISOFORM 2
(Homo
sapiens)		3 / 3ARG A 105
GLU A  93
ARG A 124
None
0.66A16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens)		3 / 3ARG A  67
GLU A  53
ARG A 206
None
0.96A22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		2pfr ARYLAMINE
N-ACETYLTRANSFERASE
2
(Homo
sapiens)		3 / 3ARG A  62
GLU A  49
ARG A  64
UNX  A1004 (-4.2A)
None
UNX  A1004 (-4.0A)
0.81A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		2y4t DNAJ HOMOLOG
SUBFAMILY C MEMBER 3
(Homo
sapiens)		3 / 3ARG A 194
GLU A 182
ARG A 191
None
0.98A18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		3d8d AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER 1
(Homo
sapiens)		3 / 3ARG A 470
GLU A 379
ARG A 451
None
0.98A17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		3n9v TYPE II
INOSITOL-1,4,5-TRISP
HOSPHATE
5-PHOSPHATASE
(Homo
sapiens)		3 / 3ARG A 411
GLU A 407
ARG A 451
None
0.92A20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		3ojy COMPLEMENT COMPONENT
C8 BETA CHAIN
(Homo
sapiens)		3 / 3ARG B  82
GLU B  69
ARG B  83
None
0.78A20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		3py7 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PAXILLIN
LD1,PROTEIN E6
CHIMERA
(Escherichia
coli;
Homo
sapiens;
Deltapapillomavi
rus
4)		3 / 3ARG A 448
GLU A 441
ARG A 449
None
0.67A19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		3q6m HEAT SHOCK PROTEIN
HSP 90-ALPHA
(Homo
sapiens)		3 / 3ARG A 338
GLU A 336
ARG A 367
None
0.88A20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL
(Homo
sapiens)		3 / 3ARG A 259
GLU A 258
ARG A 644
None
0.85A19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		4red 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens)		3 / 3ARG A 265
GLU A 281
ARG A 134
None
0.93A20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		4wq3 CALPAIN SMALL
SUBUNIT 1
(Homo
sapiens)		3 / 3ARG A  99
GLU A  97
ARG A 103
None
0.85A17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens)		3 / 3ARG A 649
GLU A 552
ARG A  93
None
0.99A18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		5o9h C5A ANAPHYLATOXIN
CHEMOTACTIC RECEPTOR
1
(Homo
sapiens)		3 / 3ARG A 148
GLU A 326
ARG A 134
TLA  A 402 (-3.2A)
TLA  A 402 (-3.6A)
None
0.66Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		6eih 14-3-3 PROTEIN
EPSILON
(Homo
sapiens)		3 / 3ARG A  61
GLU A 183
ARG A  57
None
0.75Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		6fel 14-3-3 PROTEIN GAMMA
(Homo
sapiens)		3 / 3ARG A  61
GLU A 185
ARG A  57
None
0.97Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2
(Homo
sapiens)		3 / 3ARG A 395
GLU A 433
ARG A 440
None
0.82Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_0
(NEURAMINIDASE)		2gf5 FADD PROTEIN
(Homo
sapiens)		5 / 12GLU A  19
LEU A  15
ARG A  71
ARG A  72
GLU A  22
None
1.27A17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_0
(NEURAMINIDASE)		4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens)		5 / 12GLU A2156
LEU A2155
SER A2153
ARG A2151
GLU A2124
None
1.43A19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_0
(NEURAMINIDASE)		4grl MHC CLASS II
HLA-DQ-ALPHA CHAIN
(Homo
sapiens)		5 / 12GLU A  25
LEU A 138
SER A 136
GLU A  30
ALA A  59
None
1.08A17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_0
(NEURAMINIDASE)		4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens)		5 / 12LEU A 950
ARG A 946
GLU A 949
GLU A 807
TYR A 961
None
1.32A21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_0
(NEURAMINIDASE)		5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens)		5 / 12GLU B 209
SER B 208
ARG B 313
ALA B 307
GLU B 287
None
1.30Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		2qqm NEUROPILIN-1
(Homo
sapiens)		3 / 3ARG A 334
ASP A 428
ARG A 237
EDO  A 605 (-4.1A)
EDO  A 607 (-2.7A)
EDO  A 605 ( 3.4A)
0.87A22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens)		3 / 3ARG A 384
ASP A 409
ARG A 389
None
0.84A21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		3ojy COMPLEMENT COMPONENT
C8 ALPHA CHAIN
COMPLEMENT COMPONENT
C8 BETA CHAIN
(Homo
sapiens;
Homo
sapiens)		3 / 3ARG B 102
ASP A 102
ARG B 103
None
0.97A20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		4ykn PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT
ALPHA,PHOSPHATIDYLIN
OSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM FUSION
PROTEIN
(Homo
sapiens)		3 / 3ARG A1088
ASP A1746
ARG A1038
None
1.01A13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		4z2a FURIN
(Homo
sapiens)		3 / 3ARG A 519
ASP A 259
ARG A 498
None
0.65A22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens)		3 / 3ARG A 111
ASP A  82
ARG A 107
None
1.01A20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		5n7f MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 1,ANNEXIN A2
(Homo
sapiens)		3 / 3ARG A 829
ASP A 663
ARG A 812
None
0.96A21.98