POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.


DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
1bp1 BACTERICIDAL/PERMEAB
ILITY-INCREASING
PROTEIN
(Homo
sapiens)
4 / 5PHE A 425
PHE A 262
LEU A 333
PRO A 442
PC1  A 778 (-4.7A)
None
None
None
1.41A21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
1e33 ARYLSULFATASE A
(Homo
sapiens)
4 / 5HIS P 226
PHE P 144
LEU P 197
PRO P 192
None
1.36A21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
1vzo RIBOSOMAL PROTEIN S6
KINASE ALPHA 5
(Homo
sapiens)
4 / 5PHE A 318
PHE A 317
LEU A 294
PRO A 254
None
1.35A22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens)
4 / 5HIS A 788
PHE A 711
LEU A 772
PRO A 742
None
1.25A18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens)
4 / 5PHE A 513
PHE A 512
LEU A 488
PRO A 443
None
1.33A22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
2cso PLECKSTRIN
(Homo
sapiens)
4 / 5PHE A  44
PHE A 108
LEU A  77
PRO A 100
None
1.33A18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens)
4 / 5PHE A 291
PHE A 290
LEU A 272
PRO A 232
None
1.40A22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens)
4 / 5PHE A 194
HIS A  96
PHE A 199
PRO A 426
None
1.21A16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens)
4 / 5PHE A 352
PHE A 351
LEU A 328
PRO A 292
None
1.28A21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
(Homo
sapiens)
4 / 5PHE A 475
HIS A 338
LEU A 352
PRO A 437
None
1.24A21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
3o96 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens)
4 / 5PHE A 408
PHE A 407
LEU A 384
PRO A 348
PHE  A 408 ( 1.3A)
PHE  A 407 ( 1.3A)
LEU  A 384 ( 0.6A)
PRO  A 348 ( 1.1A)
1.23A21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
3qyb TBC1 DOMAIN FAMILY
MEMBER 4
(Homo
sapiens)
4 / 5PHE A 975
HIS A1022
PHE A 981
LEU A 878
None
1.40A22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
3qye TBC1 DOMAIN FAMILY
MEMBER 1
(Homo
sapiens)
4 / 5PHE A 856
HIS A 903
PHE A 862
LEU A 758
None
1.42A22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
3rmv GLYCOGENIN-1
(Homo
sapiens)
4 / 5PHE A 100
HIS A 212
PHE A 137
PRO A 126
None
MN  A 263 ( 3.3A)
None
None
1.30A22.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
4bn5 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL
(Homo
sapiens)
4 / 5PHE A 180
HIS A 248
LEU A 298
PRO A 326
SR7  A1396 (-3.7A)
SR7  A1396 ( 3.5A)
None
None
0.76A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
4bn5 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL
(Homo
sapiens)
4 / 5PHE A 180
HIS A 248
PHE A 294
LEU A 298
SR7  A1396 (-3.7A)
SR7  A1396 ( 3.5A)
SR7  A1396 (-3.5A)
None
0.60A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens)
4 / 5PHE A 916
PHE A 915
LEU A 892
PRO A 856
None
1.35A21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
4gnk 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens)
4 / 5PHE B  28
PHE B 120
LEU B  90
PRO B  81
None
1.45A13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens)
4 / 5PHE A 408
PHE A 407
LEU A 384
PRO A 348
None
1.27A21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens)
4 / 5PHE A 453
PHE A 452
LEU A 429
PRO A 390
None
1.28A17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
4nge PRESEQUENCE
PROTEASE,
MITOCHONDRIAL
(Homo
sapiens)
4 / 5PHE D  88
PHE D 148
LEU D 111
PRO D 122
None
1.35A16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
4nge PRESEQUENCE
PROTEASE,
MITOCHONDRIAL
(Homo
sapiens)
4 / 5PHE D 168
HIS D 254
PHE D 169
LEU D 172
None
None
MLY  D 287 ( 4.5A)
None
1.44A16.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
5btr NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens)
4 / 5PHE A 297
HIS A 363
LEU A 418
PRO A 447
None
0.82A32.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens)
4 / 5PHE A 119
HIS A 187
LEU A 239
PRO A 268
None
1.14A44.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
5j3p TYROSYL-DNA
PHOSPHODIESTERASE 2
(Homo
sapiens)
4 / 5PHE A 259
PHE A 319
LEU A 334
PRO A 290
None
1.39A24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens)
4 / 5PHE A 211
HIS A 111
PHE A 216
PRO A 443
None
1.37A15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
5m23 WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens)
4 / 5PHE A 263
PHE A 219
LEU A 234
PRO A 216
7DC  A 401 (-3.9A)
None
None
None
1.44A19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens)
4 / 5PHE A 453
PHE A 452
LEU A 429
PRO A 390
None
1.25A22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
6byn WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens)
4 / 5PHE W 263
PHE W 219
LEU W 234
PRO W 216
None
1.45A16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
1i4e CASPASE-8
(Homo
sapiens)
4 / 6PHE B2476
PHE B2356
GLU B2445
VAL B2446
None
1.25A19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
1wao SERINE/THREONINE
PROTEIN PHOSPHATASE
5
(Homo
sapiens)
4 / 6GLU 1 305
PHE 1 335
GLU 1 318
VAL 1 319
None
1.41A18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens)
4 / 6PHE A 302
ARG A 301
GLU A 343
GLU A 394
None
1.02A20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens)
4 / 6PHE A 302
ARG A 301
GLU A 394
VAL A 395
None
1.39A20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
3h68 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Homo
sapiens)
4 / 6GLU A 305
PHE A 335
GLU A 318
VAL A 319
None
1.36A22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
3lgg ADENOSINE DEAMINASE
CECR1
(Homo
sapiens)
4 / 6PHE A  60
GLU A  68
PHE A  73
GLU A 208
None
1.03A20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
3o47 ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1,
ADP-RIBOSYLATION
FACTOR 1
(Homo
sapiens)
4 / 6ARG A 239
GLU A 243
PHE A 212
VAL A 153
None
1.36A21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
3thz DNA MISMATCH REPAIR
PROTEIN MSH2
(Homo
sapiens)
4 / 6ARG A  55
GLU A  56
PHE A  88
VAL A  78
None
1.41A14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
3uem PROTEIN
DISULFIDE-ISOMERASE
(Homo
sapiens)
4 / 6ARG A 452
PHE A 446
GLU A 433
VAL A 432
None
1.35A22.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
4bn5 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL
(Homo
sapiens)
4 / 6GLU A 177
PHE A 294
GLU A 323
VAL A 324
SR7  A1396 (-4.4A)
SR7  A1396 (-3.5A)
None
None
1.35A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
4bn5 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL
(Homo
sapiens)
4 / 6PHE A 157
GLU A 177
PHE A 294
VAL A 324
SR7  A1396 (-3.7A)
SR7  A1396 (-4.4A)
SR7  A1396 (-3.5A)
None
1.32A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens)
4 / 6PHE A 800
GLU A 738
PHE A 737
VAL A 713
None
1.30A8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2
(Homo
sapiens)
4 / 6PHE A 184
PHE A  34
GLU A 235
VAL A 236
6TM  A 502 (-3.4A)
None
None
None
1.17A22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
5oaf RUVB-LIKE 1
(Homo
sapiens)
4 / 6ARG A 118
GLU A 114
GLU A 100
VAL A 101
None
1.36A13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
5oed GTGE
RAS-RELATED PROTEIN
RAB-32
(Homo
sapiens;
Salmonella
enterica)
4 / 6PHE B  88
ARG B  87
GLU B  86
GLU A 198
None
None
GDP  B 900 (-4.0A)
None
1.21A14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
6fae ADP-RIBOSYLATION
FACTOR 1
(Homo
sapiens)
4 / 6GLU B 113
PHE B  82
GLU B 106
VAL B  23
None
1.16A13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_H_BBIH405_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
5jjd COLLAGEN TYPE IV
ALPHA-3-BINDING
PROTEIN
(Homo
sapiens)
4 / 4ARG B 442
GLU B 446
PHE B 579
VAL B 525
PGE  B 604 ( 3.5A)
PGE  B 604 ( 3.4A)
PGE  B 604 (-2.7A)
PGE  B 604 ( 4.6A)
1.34A22.18