POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JJ8_A_AZZA1211_1
(DEOXYNUCLEOSIDE
KINASE)		2a30 DEOXYCYTIDINE KINASE
(Homo
sapiens)		7 / 10GLU A  53
VAL A  55
TRP A  58
PHE A  96
GLN A  97
ARG A 128
PHE A 137
DCZ  A 302 (-3.0A)
None
None
DCZ  A 302 (-4.6A)
DCZ  A 302 (-3.2A)
DCZ  A 302 (-4.1A)
DCZ  A 302 (-3.8A)
0.61A32.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JJ8_A_AZZA1211_1
(DEOXYNUCLEOSIDE
KINASE)		2ocp DEOXYGUANOSINE
KINASE
(Homo
sapiens)		6 / 10VAL A  72
TRP A  75
PHE A 110
GLN A 111
ARG A 142
PHE A 151
DTP  A 301 (-4.1A)
None
DTP  A 301 (-4.2A)
DTP  A 301 (-2.9A)
DTP  A 301 (-3.2A)
DTP  A 301 (-3.3A)
0.75A33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JJ8_B_AZZB1211_1
(DEOXYNUCLEOSIDE
KINASE)		2a30 DEOXYCYTIDINE KINASE
(Homo
sapiens)		8 / 12GLU A  53
TRP A  58
LEU A  82
TYR A  86
PHE A  96
GLN A  97
ARG A 128
PHE A 137
DCZ  A 302 (-3.0A)
None
DCZ  A 302 ( 4.9A)
DCZ  A 302 (-4.6A)
DCZ  A 302 (-4.6A)
DCZ  A 302 (-3.2A)
DCZ  A 302 (-4.1A)
DCZ  A 302 (-3.8A)
0.75A32.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_B_AZZB1211_1
(DEOXYNUCLEOSIDE
KINASE)		2i2r KV
CHANNEL-INTERACTING
PROTEIN 1
(Homo
sapiens)		5 / 12LEU E  94
TYR E  78
PHE E  74
VAL E 106
PHE E 111
None
1.28A20.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JJ8_B_AZZB1211_1
(DEOXYNUCLEOSIDE
KINASE)		2ocp DEOXYGUANOSINE
KINASE
(Homo
sapiens)		7 / 12TRP A  75
LEU A  96
TYR A 100
PHE A 110
GLN A 111
ARG A 142
PHE A 151
None
DTP  A 301 (-4.6A)
DTP  A 301 (-4.5A)
DTP  A 301 (-4.2A)
DTP  A 301 (-2.9A)
DTP  A 301 (-3.2A)
DTP  A 301 (-3.3A)
0.79A33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_B_AZZB1211_1
(DEOXYNUCLEOSIDE
KINASE)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		5 / 12LEU A  90
TYR A  51
PHE A  70
VAL A  68
PHE A 179
None
1.37A21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_B_AZZB1211_1
(DEOXYNUCLEOSIDE
KINASE)		3u4b CH02 LIGHT CHAIN
(Homo
sapiens)		5 / 12GLU L  17
LEU L 106
PHE L  83
VAL L  78
ALA L  19
None
1.16A19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_B_AZZB1211_1
(DEOXYNUCLEOSIDE
KINASE)		3uyq CARBONIC ANHYDRASE 3
(Homo
sapiens)		5 / 12LEU A  90
TYR A  51
PHE A  70
VAL A  68
PHE A 178
None
1.37A19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_B_AZZB1211_1
(DEOXYNUCLEOSIDE
KINASE)		4zdl O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Homo
sapiens)		5 / 12LEU A 282
PHE A 286
VAL A 257
MET A 263
ALA A 129
None
1.36A18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_B_AZZB1211_1
(DEOXYNUCLEOSIDE
KINASE)		5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL
(Homo
sapiens)		5 / 12TRP A 840
LEU A 142
GLN A 846
VAL A 838
MET A 848
None
1.38A21.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		2a30 DEOXYCYTIDINE KINASE
(Homo
sapiens)		9 / 12GLU A  53
VAL A  55
TRP A  58
LEU A  82
MET A  85
PHE A  96
GLN A  97
ARG A 128
PHE A 137
DCZ  A 302 (-3.0A)
None
None
DCZ  A 302 ( 4.9A)
DCZ  A 302 ( 4.3A)
DCZ  A 302 (-4.6A)
DCZ  A 302 (-3.2A)
DCZ  A 302 (-4.1A)
DCZ  A 302 (-3.8A)
0.68A32.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		2a30 DEOXYCYTIDINE KINASE
(Homo
sapiens)		9 / 12ILE A  30
GLU A  53
VAL A  55
TRP A  58
LEU A  82
PHE A  96
GLN A  97
ARG A 128
PHE A 137
DCZ  A 302 ( 4.3A)
DCZ  A 302 (-3.0A)
None
None
DCZ  A 302 ( 4.9A)
DCZ  A 302 (-4.6A)
DCZ  A 302 (-3.2A)
DCZ  A 302 (-4.1A)
DCZ  A 302 (-3.8A)
0.73A32.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1
(Homo
sapiens)		5 / 12ILE A1068
VAL A 108
LEU A  80
PHE A  78
ALA A 104
None
1.25A11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		2lkn AH
RECEPTOR-INTERACTING
PROTEIN
(Homo
sapiens)		5 / 12VAL A 101
LEU A 105
MET A  60
PHE A 150
MET A 152
None
1.40A20.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		2ocp DEOXYGUANOSINE
KINASE
(Homo
sapiens)		6 / 12GLU A  70
VAL A  72
TRP A  75
MET A  99
PHE A 110
GLN A 111
None
DTP  A 301 (-4.1A)
None
DTP  A 301 ( 3.9A)
DTP  A 301 (-4.2A)
DTP  A 301 (-2.9A)
1.23A33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		2ocp DEOXYGUANOSINE
KINASE
(Homo
sapiens)		8 / 12ILE A  47
VAL A  72
TRP A  75
LEU A  96
PHE A 110
GLN A 111
ARG A 142
PHE A 151
DTP  A 301 (-3.8A)
DTP  A 301 (-4.1A)
None
DTP  A 301 (-4.6A)
DTP  A 301 (-4.2A)
DTP  A 301 (-2.9A)
DTP  A 301 (-3.2A)
DTP  A 301 (-3.3A)
0.78A33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		2ocp DEOXYGUANOSINE
KINASE
(Homo
sapiens)		7 / 12VAL A  72
TRP A  75
LEU A  96
MET A  99
PHE A 110
GLN A 111
ARG A 142
DTP  A 301 (-4.1A)
None
DTP  A 301 (-4.6A)
DTP  A 301 ( 3.9A)
DTP  A 301 (-4.2A)
DTP  A 301 (-2.9A)
DTP  A 301 (-3.2A)
0.88A33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		3j0k DNA-DIRECTED RNA
POLYMERASES I, II,
AND III 23 KDA
POLYPEPTIDE
(Homo
sapiens)		5 / 12GLU F 124
VAL F 109
LEU F 111
ARG F  97
ALA F  98
None
1.34A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		3mwe ATP-CITRATE SYNTHASE
(Homo
sapiens)		5 / 12ILE A 414
LEU A 388
MET A 391
PHE A 354
ALA A 280
None
None
None
None
TLA  A 427 ( 4.2A)
0.83A19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		3sei CASKIN-1
(Homo
sapiens)		5 / 12ILE A  47
VAL A  10
TRP A  13
LEU A  14
PHE A  17
None
1.23A20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		4elj RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens)		5 / 12ILE A 172
GLU A 280
LEU A 220
MET A 219
PHE A 216
None
1.33A18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		4giw RUN AND SH3
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		5 / 12ILE A 124
VAL A  86
LEU A 140
PHE A 157
ALA A  61
None
1.46A20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		4nc6 RAB
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens)		5 / 12ILE A 706
TRP A 727
LEU A 787
PHE A 783
ALA A 720
None
1.24A21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		4yj5 PYRUVATE KINASE PKM
(Homo
sapiens)		5 / 12ILE A 156
GLU A 154
VAL A 132
LEU A 203
ALA A 138
None
1.26A20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens)		5 / 12ILE A1814
MET A1840
ALA A 952
PHE A 949
MET A1786
None
1.48A9.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens)		5 / 12ILE A1068
VAL A 108
LEU A  80
PHE A  78
ALA A 104
None
1.26A14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		5te1 ATP-CITRATE SYNTHASE
(Homo
sapiens)		5 / 12ILE A 414
LEU A 388
MET A 391
PHE A 354
ALA A 280
None
None
None
None
7A2  A 901 ( 4.1A)
0.93A14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		5ugf PURINE NUCLEOSIDE
PHOSPHORYLASE
(Homo
sapiens)		5 / 12GLU A 224
VAL A  96
LEU A  93
ALA A 228
MET A 162
None
1.29A22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		5vni PROTEIN TRANSPORT
PROTEIN SEC24A
(Homo
sapiens)		5 / 12GLU B1058
TRP B 995
LEU B1066
MET B1069
ARG B 980
None
1.35A14.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JJ8_D_AZZD1211_1
(DEOXYNUCLEOSIDE
KINASE)		2a30 DEOXYCYTIDINE KINASE
(Homo
sapiens)		7 / 10ILE A  30
GLU A  53
TRP A  58
PHE A  96
GLN A  97
ARG A 128
PHE A 137
DCZ  A 302 ( 4.3A)
DCZ  A 302 (-3.0A)
None
DCZ  A 302 (-4.6A)
DCZ  A 302 (-3.2A)
DCZ  A 302 (-4.1A)
DCZ  A 302 (-3.8A)
0.68A32.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JJ8_D_AZZD1211_1
(DEOXYNUCLEOSIDE
KINASE)		2ocp DEOXYGUANOSINE
KINASE
(Homo
sapiens)		6 / 10ILE A  47
TRP A  75
PHE A 110
GLN A 111
ARG A 142
PHE A 151
DTP  A 301 (-3.8A)
None
DTP  A 301 (-4.2A)
DTP  A 301 (-2.9A)
DTP  A 301 (-3.2A)
DTP  A 301 (-3.3A)
0.76A33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_D_AZZD1211_1
(DEOXYNUCLEOSIDE
KINASE)		4xnv P2Y PURINOCEPTOR 1,
RUBREDOXIN, P2Y
PURINOCEPTOR 1
(Clostridium
pasteurianum;
Homo
sapiens)		5 / 10PHE A 298
VAL A 302
ARG A 285
ALA A 286
PHE A 290
Y01  A1103 ( 4.9A)
Y01  A1103 ( 4.3A)
OLC  A1112 (-4.8A)
None
OLC  A1106 ( 4.9A)
1.04A16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE
(Homo
sapiens)		4 / 8GLU A 249
SER A 374
VAL A 403
HIS A 406
None
1.15A22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		1qgr PROTEIN (IMPORTIN
BETA SUBUNIT)
(Homo
sapiens)		4 / 8GLU A 626
GLN A 665
VAL A 705
HIS A 706
None
1.18A21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		2lzu LIM
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens)		4 / 8TYR A 105
GLU A 107
GLN A  96
CYH A  91
None
None
None
ZN  A 202 (-2.3A)
1.20A10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		2m0u NA(+)/H(+) EXCHANGE
REGULATORY COFACTOR
NHE-RF1
(Homo
sapiens)		4 / 8TYR A  38
GLN A  37
VAL A  91
ARG A  58
None
1.26A11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		2qqm NEUROPILIN-1
(Homo
sapiens)		4 / 8TYR A 480
GLU A 483
SER A 450
VAL A 510
None
1.13A20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		2yf0 MYOTUBULARIN-RELATED
PROTEIN 6
(Homo
sapiens)		4 / 8GLU A  57
SER A  55
GLN A  71
VAL A  12
None
0.93A21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		2z5e PROTEASOME
ASSEMBLING CHAPERONE
3
(Homo
sapiens)		4 / 8GLU A  89
GLN A 120
VAL A  23
CYH A  25
None
1.11A11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11
(Homo
sapiens)		4 / 8TYR A 200
GLU A 192
SER A 293
HIS A 142
None
1.13A20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens)		4 / 8GLU A  55
SER A  45
VAL A 314
HIS A 415
None
None
None
FAD  A 479 ( 4.9A)
1.01A22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		4cvh ISOPRENOID SYNTHASE
DOMAIN-CONTAINING
PROTEIN
(Homo
sapiens)		4 / 8GLU A 239
SER A 211
GLN A 215
VAL A 221
None
1.06A21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		4fdd TRANSPORTIN-1
(Homo
sapiens)		4 / 8TYR A 260
VAL A 272
CYH A 236
ARG A 264
None
1.00A20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		4gs4 ALPHA-TUBULIN
N-ACETYLTRANSFERASE
(Homo
sapiens)		4 / 8TYR A 101
GLU A 117
VAL A  76
HIS A  75
None
1.22A17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		4if5 ALPHA-TUBULIN
N-ACETYLTRANSFERASE
(Homo
sapiens)		4 / 8TYR A 101
GLU A 117
VAL A  76
HIS A  75
None
None
None
CL  A 202 (-4.4A)
1.26A15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens)		4 / 8GLU A 181
SER A 514
GLN A 518
VAL A 525
None
1.25A22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		5ggg PROTEIN
O-LINKED-MANNOSE
BETA-1,2-N-ACETYLGLU
COSAMINYLTRANSFERASE
1
(Homo
sapiens)		4 / 8TYR A 441
SER A 535
HIS A 608
ARG A 613
None
1.21A23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens)		4 / 8GLU A 181
SER A 514
GLN A 518
VAL A 525
None
1.23A22.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		1tf0 SERUM ALBUMIN
(Homo
sapiens)		5 / 8LEU A 115
HIS A 146
PHE A 149
GLY A 189
LYS A 190
None
0.80A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		1w8d 2,4-DIENOYL-COA
REDUCTASE,
MITOCHONDRIAL
PRECURSOR
(Homo
sapiens)		4 / 8LEU A 131
ILE A 179
GLY A 189
LYS A 188
None
0.97A18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		1z5v TUBULIN GAMMA-1
CHAIN
(Homo
sapiens)		5 / 8LEU A 192
ILE A 141
HIS A 139
ARG A 194
GLY A 148
None
1.16A19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens)		4 / 8LEU A 221
ILE A 283
HIS A 140
ARG A 280
None
0.97A19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		2eh0 KINESIN-LIKE PROTEIN
KIF1B
(Homo
sapiens)		4 / 8LEU A  74
ILE A 101
ARG A  96
GLY A  98
None
0.94A11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		2vd5 DMPK PROTEIN
(Homo
sapiens)		4 / 8ILE A 183
HIS A 187
ARG A 324
GLY A 326
None
0.91A20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens)		4 / 8LEU C 182
ILE C 177
HIS C 174
GLY C 215
None
0.89A19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		3fd5 SELENIDE, WATER
DIKINASE 1
(Homo
sapiens)		4 / 8LEU A  20
ILE A 144
PHE A 148
GLY A 173
None
0.94A20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		3fs1 HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens)		4 / 8LEU A 332
ILE A 284
HIS A 214
GLY A 216
None
0.91A18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		3jwo HIV-1 GP120 ENVELOPE
GLYCOPROTEIN
(Homo
sapiens)		4 / 8LEU A 483
ILE A 251
HIS A 249
GLY A 263
None
0.62A18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		3k3n PHD FINGER PROTEIN 8
(Homo
sapiens)		4 / 8LEU A 276
ILE A 318
PHE A 246
GLY A 294
None
0.88A18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		3kv4 PHD FINGER PROTEIN 8
(Homo
sapiens)		4 / 8LEU A 276
ILE A 318
PHE A 246
GLY A 294
None
0.91A21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		3kv6 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1D
(Homo
sapiens)		5 / 8LEU A 311
ILE A 353
PHE A 281
ARG A 313
GLY A 329
None
0.98A20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		3qfv CDC42BPB PROTEIN
(Homo
sapiens)		4 / 8ILE A 188
HIS A 192
ARG A 327
GLY A 329
None
0.90A21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		3t6g BREAST CANCER
ANTI-ESTROGEN
RESISTANCE PROTEIN 1
SH2
DOMAIN-CONTAINING
PROTEIN 3C
(Homo
sapiens)		4 / 8LEU A 623
ILE B 786
ARG B 824
GLY B 825
None
0.94A21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		3u78 LYSINE-SPECIFIC
DEMETHYLASE 7
(Homo
sapiens)		5 / 8LEU A 311
ILE A 353
PHE A 281
ARG A 313
GLY A 329
None
None
None
SO4  A 704 (-4.0A)
None
1.02A21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens)		4 / 8LEU A 678
ILE A 675
HIS A 671
GLY A 692
None
0.92A21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		4f0x MALONYL-COA
DECARBOXYLASE,
MITOCHONDRIAL
(Homo
sapiens)		4 / 8LEU A 328
ILE A 265
HIS A 219
GLY A 443
None
0.96A21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1
(Homo
sapiens)		4 / 8LEU A 966
ILE A 995
ARG A 979
GLY A 988
None
0.86A22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		4iqr HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA
(Homo
sapiens)		4 / 8LEU A 332
ILE A 284
HIS A 214
GLY A 216
None
0.92A19.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B9M_A_AZZA1009_1
(SERUM ALBUMIN)		1tf0 SERUM ALBUMIN
(Homo
sapiens)		5 / 9LYS A 195
LYS A 199
VAL A 241
HIS A 242
ARG A 257
CIT  A2001 (-4.1A)
CIT  A2001 ( 2.7A)
None
DKA  A1003 (-3.7A)
DKA  A1003 (-4.1A)
0.92A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		1sk4 PEPTIDOGLYCAN
RECOGNITION PROTEIN
I-ALPHA
(Homo
sapiens)		4 / 5PHE A 281
ALA A 210
GLY A 211
TYR A 280
None
1.22A12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		1zef ALKALINE PHOSPHATASE
(Homo
sapiens)		4 / 5ASN A  84
PHE A 107
ALA A  94
GLY A  93
None
PHE  A 802 (-4.4A)
None
SEP  A  92 ( 2.4A)
0.99A20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		2r3v MEVALONATE KINASE
(Homo
sapiens)		4 / 5ASN A 205
PHE A 190
ALA A 189
GLY A 192
None
1.18A19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens)		4 / 5PHE A 140
ALA A 178
GLY A 186
TYR A 185
None
1.15A22.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM
(Homo
sapiens)		5 / 5ASN A 282
PHE A 285
ALA A 610
GLY A 612
TYR A 613
None
0.22A80.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		3ldo 78 KDA
GLUCOSE-REGULATED
PROTEIN
(Homo
sapiens)		4 / 5ASN A 177
PHE A 176
ALA A 179
GLY A 100
None
1.14A18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN
(Homo
sapiens)		4 / 5ASN A 177
PHE A 176
ALA A 179
GLY A 100
None
1.11A21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2
(Homo
sapiens)		4 / 5PHE A 341
ALA A 273
GLY A 275
TYR A 276
None
1.21A7.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		1uou THYMIDINE
PHOSPHORYLASE
(Homo
sapiens)		6 / 11ARG A 202
VAL A 208
ILE A 214
SER A 217
LYS A 221
LEU A 251
CMU  A1481 (-2.8A)
None
CMU  A1481 (-3.9A)
CMU  A1481 (-2.7A)
CMU  A1481 (-2.6A)
None
0.32A38.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		1uou THYMIDINE
PHOSPHORYLASE
(Homo
sapiens)		5 / 11THR A 118
TYR A 199
SER A 217
LYS A 221
LEU A 251
None
CMU  A1481 (-4.7A)
CMU  A1481 (-2.7A)
CMU  A1481 (-2.6A)
None
1.07A38.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		1uou THYMIDINE
PHOSPHORYLASE
(Homo
sapiens)		6 / 11TYR A 199
ARG A 202
ILE A 214
SER A 217
LYS A 221
LEU A 251
CMU  A1481 (-4.7A)
CMU  A1481 (-2.8A)
CMU  A1481 (-3.9A)
CMU  A1481 (-2.7A)
CMU  A1481 (-2.6A)
None
0.66A38.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		1xtj PROBABLE
ATP-DEPENDENT RNA
HELICASE P47
(Homo
sapiens)		5 / 11THR A 389
LEU A 386
ILE A 411
SER A 412
LEU A 400
None
1.17A20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		3tw8 DENN
DOMAIN-CONTAINING
PROTEIN 1B
(Homo
sapiens)		5 / 11LEU A 261
TYR A 244
VAL A 197
ILE A 248
LEU A 252
None
1.46A20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		4hj2 GLUTATHIONE
S-TRANSFERASE A1
(Homo
sapiens)		5 / 11THR A 193
LEU A 198
VAL A 161
ILE A 158
LEU A 153
None
1.38A17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		4w79 PROTEIN N-TERMINAL
GLUTAMINE
AMIDOHYDROLASE
(Homo
sapiens)		5 / 11LEU A 175
TYR A  80
VAL A  82
SER A  56
PHE A 142
None
1.40A17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		5j12 CYTOKINE
RECEPTOR-LIKE FACTOR
2
(Homo
sapiens)		5 / 11VAL C 170
ILE C 172
SER C 162
PHE C 127
LEU C 175
None
1.18A19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		5mpo MOLYBDOPTERIN
SYNTHASE SULFUR
CARRIER SUBUNIT
(Homo
sapiens)		5 / 11THR A  43
LEU A  48
TYR A  11
VAL A   9
ILE A  26
None
1.41A12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		5xau LAMININ SUBUNIT
ALPHA-5
(Homo
sapiens)		5 / 11THR A3108
ILE A2954
SER A2955
PHE A2951
LEU A3103
None
1.33A21.87