POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.


DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUF_B_AZ1B503_1
(DIAMINOPIMELATE
DECARBOXYLASE)
4dtg HUMANIZED
RECOMBINANT FAB
FRAGMENT, FAB 2021,
OF A MURINE
ANTIBODY, HEAVY
CHAIN
TISSUE FACTOR
PATHWAY INHIBITOR
(Homo
sapiens)
4 / 6GLU K  11
SER H  54
TYR H  59
TYR H  57
PGE  H 304 ( 3.5A)
None
None
None
1.21A9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUF_B_AZ1B503_1
(DIAMINOPIMELATE
DECARBOXYLASE)
4n2c PROTEIN-ARGININE
DEIMINASE TYPE-2
(Homo
sapiens)
4 / 6GLU A 474
SER A 404
ARG A 441
ARG A 580
None
1.29A19.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)
1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE
(Homo
sapiens)
4 / 7GLY A 159
GLY A 161
LYS A 181
LEU A 183
None
0.37A39.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)
1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens)
4 / 7GLY L 198
GLY L 203
PHE L 204
LEU L 338
None
0.81A19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)
1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens)
4 / 7GLY A 312
SER A 311
LEU A 349
GLU A  76
ILP  A 400 (-3.5A)
None
None
None
0.79A22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)
1lm7 SUBDOMAIN OF
DESMOPLAKIN
CARBOXY-TERMINAL
DOMAIN (DPCT)
(Homo
sapiens)
4 / 7GLY A2319
GLY A2322
PHE A2325
LEU A2292
None
0.87A22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)
1tg6 PUTATIVE
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Homo
sapiens)
4 / 7GLY A  33
GLY A  67
SER A  97
LEU A 102
None
0.83A22.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)
1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens)
4 / 7GLY A 252
GLY A 254
SER A 255
LYS A 274
BI1  A1000 (-3.6A)
None
None
BI1  A1000 (-3.5A)
0.75A34.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)
2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens)
4 / 7GLY A 330
SER A 329
LEU A 367
GLU A  94
CBC  A1401 ( 3.4A)
None
None
None
0.75A21.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)
2i0e PROTEIN KINASE
C-BETA II
(Homo
sapiens)
4 / 7GLY A 349
GLY A 351
LYS A 371
LEU A 373
PDS  A 901 ( 3.7A)
None
PDS  A 901 ( 4.5A)
None
0.87A36.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)
2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G
(Homo
sapiens)
4 / 7GLY A  30
GLY A  32
PHE A  34
LYS A  52
None
None
None
EDO  A1304 ( 2.9A)
0.49A30.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens)
4 / 7GLY A  83
GLY A  85
LYS A 105
LEU A 107
ANP  A1480 ( 4.3A)
ANP  A1480 ( 3.8A)
ANP  A1480 (-3.4A)
None
0.53A35.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens)
4 / 7GLY C  56
GLY C  58
SER C  59
GLU C 138
ANP  C   2 (-3.3A)
ANP  C   2 (-3.0A)
None
ANP  C   2 (-4.1A)
0.74A28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens)
5 / 7GLY C  56
GLY C  58
SER C  59
LYS C  78
LEU C  80
ANP  C   2 (-3.3A)
ANP  C   2 (-3.0A)
None
ANP  C   2 (-3.6A)
None
1.13A28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)
2z8c INSULIN RECEPTOR
(Homo
sapiens)
4 / 7GLY A1003
GLY A1005
SER A1006
PHE A1007
S91  A   1 ( 3.9A)
None
None
None
0.57A23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3
(Homo
sapiens)
4 / 7GLY A  20
GLY A  22
LYS A  42
GLU A 100
4RB  A 401 (-3.6A)
None
4RB  A 401 ( 2.8A)
4RB  A 401 (-3.8A)
0.52A26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)
3gqc DNA REPAIR PROTEIN
REV1
(Homo
sapiens)
4 / 7GLY A 609
GLY A 611
SER A 612
LEU A 615
None
0.71A20.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)
3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1
(Homo
sapiens)
5 / 7GLY A 105
GLY A 107
SER A 108
PHE A 109
GLU A 183
None
GMG  A   1 (-3.3A)
None
None
None
1.00A38.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens)
4 / 7GLY A  40
GLY A  42
LEU A  64
GLU A 117
None
0.43A27.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens)
4 / 7GLY A 695
GLY A 697
LYS A 721
LEU A 723
ITI  A   1 ( 4.8A)
None
ITI  A   1 (-2.6A)
None
0.77A22.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens)
5 / 7GLY A  50
GLY A  52
SER A  53
LEU A  74
GLU A 127
XFE  A 351 ( 4.0A)
None
None
None
XFE  A 351 (-4.2A)
1.12A94.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens)
5 / 7GLY A  50
GLY A  52
SER A  53
PHE A  54
GLU A 127
XFE  A 351 ( 4.0A)
None
None
None
XFE  A 351 (-4.2A)
1.19A94.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens)
5 / 7GLY A  50
SER A  53
LYS A  72
LEU A  74
GLU A 127
XFE  A 351 ( 4.0A)
None
None
None
XFE  A 351 (-4.2A)
1.13A94.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)
3nuu PKB-LIKE
(Homo
sapiens)
5 / 7GLY A  89
GLY A  91
SER A  92
LEU A 113
GLU A 166
JOZ  A 361 ( 4.3A)
SO4  A   5 ( 4.4A)
SO4  A   5 (-4.4A)
None
None
1.34A37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)
3nuu PKB-LIKE
(Homo
sapiens)
5 / 7GLY A  89
SER A  92
LYS A 111
LEU A 113
GLU A 166
JOZ  A 361 ( 4.3A)
SO4  A   5 (-4.4A)
SO4  A   5 (-2.8A)
None
None
1.30A37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)
3o96 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens)
4 / 7GLY A 157
GLY A 159
LYS A 179
LEU A 181
GLY  A 157 ( 0.0A)
GLY  A 159 ( 0.0A)
LYS  A 179 ( 0.0A)
LEU  A 181 ( 0.6A)
0.18A34.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
1gng GLYCOGEN SYNTHASE
KINASE-3 BETA
(Homo
sapiens)
5 / 7GLY A  63
GLY A  65
SER A  66
GLY A  68
VAL A  70
None
0.64A23.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE
(Homo
sapiens)
5 / 7GLY A 159
GLY A 161
GLY A 164
VAL A 166
LEU A 183
None
0.32A39.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
1rjb FL CYTOKINE RECEPTOR
(Homo
sapiens)
4 / 7GLY A 617
GLY A 619
GLY A 622
VAL A 624
None
0.30A24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG
(Homo
sapiens)
4 / 7GLY A 596
GLY A 598
GLY A 601
VAL A 603
None
None
None
STI  A   3 ( 4.6A)
0.34A24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
1tki TITIN
(Homo
sapiens)
4 / 7GLY A  31
GLY A  33
GLY A  36
VAL A  38
None
0.37A25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens)
4 / 7GLY A 345
GLY A 347
GLY A 350
VAL A 352
STU  A 100 (-3.3A)
None
None
STU  A 100 (-4.8A)
0.27A22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3
(Homo
sapiens)
4 / 7GLY A 163
GLY A 165
GLY A 168
VAL A 170
None
0.30A23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens)
5 / 7GLY A 274
GLY A 276
GLY A 279
VAL A 281
LEU A 297
H8H  A 534 ( 3.8A)
None
None
H8H  A 534 (-4.4A)
None
0.43A22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens)
4 / 7GLY A 252
GLY A 254
GLY A 257
VAL A 259
None
None
None
1BM  A 499 ( 4.8A)
0.24A23.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
2i0e PROTEIN KINASE
C-BETA II
(Homo
sapiens)
5 / 7GLY A 349
GLY A 351
SER A 352
GLY A 354
LEU A 373
PDS  A 901 ( 3.7A)
None
None
None
None
1.32A36.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G
(Homo
sapiens)
4 / 7GLY A  30
GLY A  32
PHE A  34
VAL A  37
None
None
None
J60  A1305 (-4.8A)
0.26A30.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK
(Homo
sapiens)
4 / 7GLY A 252
GLY A 254
GLY A 257
VAL A 259
None
0.25A23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR
(Homo
sapiens)
4 / 7GLY A 589
GLY A 591
GLY A 594
VAL A 596
None
0.22A25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens)
5 / 7GLY A 725
GLY A 727
GLY A 730
VAL A 732
LEU A 753
None
None
None
GW7  A   1 ( 4.8A)
None
0.85A24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens)
5 / 7GLY C  56
GLY C  58
SER C  59
GLY C  61
VAL C  63
ANP  C   2 (-3.3A)
ANP  C   2 (-3.0A)
None
ANP  C   2 (-3.8A)
ANP  C   2 (-4.2A)
0.69A28.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
2xk9 CHECKPOINT KINASE 2
(Homo
sapiens)
4 / 7GLY A 227
GLY A 229
GLY A 232
VAL A 234
XK9  A1511 ( 4.5A)
None
None
XK9  A1511 (-4.8A)
0.37A34.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
2z8c INSULIN RECEPTOR
(Homo
sapiens)
5 / 7GLY A1003
GLY A1005
SER A1006
PHE A1007
GLY A1008
S91  A   1 ( 3.9A)
None
None
None
None
0.79A23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
3coi MITOGEN-ACTIVATED
PROTEIN KINASE 13
(Homo
sapiens)
5 / 7GLY A  32
GLY A  34
GLY A  37
VAL A  39
LEU A  56
None
0.81A27.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1
(Homo
sapiens)
5 / 7GLY A 105
GLY A 107
SER A 108
GLY A 110
LEU A 129
None
GMG  A   1 (-3.3A)
None
None
None
1.16A38.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens)
4 / 7GLY A 834
GLY A 836
GLY A 839
VAL A 841
None
None
None
8ST  A2001 ( 4.6A)
0.28A23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
3kex RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3
(Homo
sapiens)
5 / 7GLY A 697
GLY A 699
PHE A 701
GLY A 702
VAL A 704
ANP  A   1 (-3.7A)
ANP  A   1 (-2.8A)
None
None
ANP  A   1 (-3.9A)
0.56A25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens)
5 / 7GLY A 695
GLY A 697
GLY A 700
VAL A 702
LEU A 723
ITI  A   1 ( 4.8A)
None
None
ITI  A   1 (-4.8A)
None
0.76A22.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens)
5 / 7GLY A  50
GLY A  52
GLY A  55
VAL A  57
LEU A  74
XFE  A 351 ( 4.0A)
None
None
XFE  A 351 ( 4.5A)
None
0.45A94.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens)
5 / 7GLY A  50
GLY A  52
SER A  53
GLY A  55
VAL A  57
XFE  A 351 ( 4.0A)
None
None
None
XFE  A 351 ( 4.5A)
0.54A94.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens)
5 / 7GLY A  50
GLY A  52
SER A  53
PHE A  54
GLY A  55
XFE  A 351 ( 4.0A)
None
None
None
None
1.00A94.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens)
4 / 7GLY A 209
GLY A 211
GLY A 214
VAL A 216
None
None
None
LDN  A 600 (-4.5A)
0.33A21.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
3o96 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens)
5 / 7GLY A 157
GLY A 159
GLY A 162
VAL A 164
LEU A 181
GLY  A 157 ( 0.0A)
GLY  A 159 ( 0.0A)
GLY  A 162 ( 0.0A)
VAL  A 164 ( 0.6A)
LEU  A 181 ( 0.6A)
0.19A34.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
3qfv CDC42BPB PROTEIN
(Homo
sapiens)
4 / 7GLY A  83
GLY A  88
VAL A  90
LEU A 107
NM7  A 416 (-3.0A)
None
NM7  A 416 (-3.7A)
EDO  A 417 (-4.6A)
0.33A33.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens)
6 / 7GLY A 362
GLY A 364
SER A 365
GLY A 367
VAL A 369
LEU A 386
07U  A   1 ( 4.2A)
None
None
None
07U  A   1 (-4.8A)
None
0.80A39.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens)
4 / 7GLY A 841
GLY A 843
GLY A 846
VAL A 848
4TT  A2001 ( 4.8A)
None
None
4TT  A2001 ( 4.5A)
0.22A22.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens)
4 / 7GLY A  11
GLY A  13
GLY A  16
VAL A  18
38R  A 350 ( 3.9A)
None
None
38R  A 350 ( 4.8A)
0.33A31.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens)
4 / 7GLY A 841
GLY A 843
GLY A 846
VAL A 848
B49  A2000 ( 4.6A)
None
None
None
0.29A23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1
(Homo
sapiens)
4 / 7GLY A  11
GLY A  13
GLY A  16
VAL A  18
D15  A 500 (-3.8A)
D15  A 500 (-3.6A)
D15  A 500 (-3.7A)
D15  A 500 (-4.6A)
0.29A24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens)
4 / 7GLY A 215
GLY A 217
GLY A 220
VAL A 222
None
None
None
TAK  A1507 (-4.7A)
0.29A21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR
(Homo
sapiens)
4 / 7GLY A 516
GLY A 518
GLY A 521
VAL A 523
None
0.25A23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens)
5 / 7GLY A  30
GLY A  32
SER A  33
GLY A  35
VAL A  37
STU  A 401 (-3.3A)
None
None
None
STU  A 401 ( 4.9A)
0.60A29.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3
(Homo
sapiens)
4 / 7GLY A 599
GLY A 601
GLY A 604
VAL A 606
None
None
None
924  A1101 ( 4.8A)
0.34A24.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens)
5 / 7GLY A 157
GLY A 159
GLY A 162
VAL A 164
LEU A 181
GOL  A 505 ( 3.4A)
0XZ  A 501 (-4.1A)
0XZ  A 501 (-3.8A)
0XZ  A 501 (-4.5A)
GOL  A 503 (-4.9A)
0.29A38.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
4hvi TYROSINE-PROTEIN
KINASE JAK3
(Homo
sapiens)
4 / 7GLY A 829
GLY A 831
GLY A 834
VAL A 836
19S  A1201 (-3.7A)
19S  A1201 ( 4.3A)
19S  A1201 ( 4.9A)
19S  A1201 (-4.4A)
0.27A24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens)
4 / 7GLY A 407
GLY A 409
SER A 410
GLY A 412
T28  A 701 ( 3.6A)
T28  A 701 ( 3.0A)
None
None
0.31A24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens)
5 / 7GLY A 274
GLY A 276
GLY A 279
VAL A 281
LEU A 297
0J9  A 601 ( 4.0A)
None
None
0J9  A 601 (-4.4A)
None
0.57A22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3
(Homo
sapiens)
4 / 7GLY A 479
GLY A 481
GLY A 484
VAL A 486
ACP  A 801 (-3.4A)
ACP  A 801 (-3.6A)
ACP  A 801 (-3.6A)
ACP  A 801 (-4.2A)
0.34A25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens)
5 / 7GLY A 414
GLY A 416
SER A 417
GLY A 419
VAL A 421
B49  A 701 ( 4.3A)
None
None
None
None
0.71A27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens)
5 / 7GLY A 198
GLY A 200
GLY A 203
VAL A 205
LEU A 222
29X  A 702 ( 4.1A)
29X  A 702 (-3.6A)
29X  A 702 (-3.5A)
29X  A 702 (-4.7A)
None
0.40A25.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens)
5 / 7GLY A 628
GLY A 630
GLY A 633
VAL A 635
LEU A 652
None
0.78A37.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1
(Homo
sapiens)
5 / 7GLY A 228
GLY A 230
SER A 231
PHE A 232
LEU A 252
None
0.79A25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1
(Homo
sapiens)
5 / 7GLY A 228
GLY A 230
SER A 231
VAL A 235
LEU A 252
None
0.36A25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens)
5 / 7GLY A 387
GLY A 389
GLY A 392
VAL A 394
LEU A 411
PZW  A 801 ( 3.8A)
None
None
PZW  A 801 (-4.6A)
None
0.77A37.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens)
5 / 7GLY A 387
GLY A 389
SER A 390
GLY A 392
LEU A 411
PZW  A 801 ( 3.8A)
None
None
None
None
1.06A37.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
4qtb MITOGEN-ACTIVATED
PROTEIN KINASE 3
(Homo
sapiens)
4 / 7GLY A  49
GLY A  51
GLY A  54
VAL A  56
None
0.37A26.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
4ra4 PROTEIN KINASE C
(Homo
sapiens)
6 / 7GLY A 346
GLY A 348
SER A 349
GLY A 351
VAL A 353
LEU A 370
3KZ  A 701 (-3.3A)
None
None
None
3KZ  A 701 (-3.9A)
None
0.71A36.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens)
5 / 7GLY A  25
GLY A  27
PHE A  29
GLY A  30
LEU A  49
STU  A 601 (-3.5A)
STU  A 601 (-3.4A)
None
None
None
1.06A23.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens)
5 / 7GLY A 105
GLY A 107
GLY A 110
VAL A 112
LEU A 129
ATP  A 501 (-3.5A)
ATP  A 501 (-3.2A)
ATP  A 501 (-3.8A)
ATP  A 501 (-4.0A)
None
0.62A84.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens)
5 / 7GLY A 105
GLY A 107
SER A 108
GLY A 110
VAL A 112
ATP  A 501 (-3.5A)
ATP  A 501 (-3.2A)
ATP  A 501 (-3.7A)
ATP  A 501 (-3.8A)
ATP  A 501 (-4.0A)
0.65A84.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens)
4 / 7GLY A 617
GLY A 619
GLY A 622
VAL A 624
None
None
None
P30  A1001 ( 4.8A)
0.17A24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K
(Homo
sapiens)
4 / 7GLY A 470
GLY A 472
GLY A 475
VAL A 477
4CV  A 801 ( 3.9A)
None
None
None
0.36A24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens)
5 / 7GLY A 618
GLY A 635
SER A 634
GLY A 636
VAL A 617
None
1.44A21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
4ylj DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 1A
(Homo
sapiens)
5 / 7GLY A 166
GLY A 168
SER A 169
GLY A 171
VAL A 173
4E1  A 505 (-3.5A)
4E1  A 505 ( 4.9A)
None
None
4E1  A 505 (-4.5A)
0.61A25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
1gng GLYCOGEN SYNTHASE
KINASE-3 BETA
(Homo
sapiens)
5 / 7GLY A  63
GLY A  65
SER A  66
VAL A  70
LYS A  85
None
0.72A23.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE
(Homo
sapiens)
5 / 7GLY A 159
GLY A 161
VAL A 166
LYS A 181
LEU A 183
None
0.32A39.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
1tki TITIN
(Homo
sapiens)
4 / 7GLY A  31
GLY A  33
VAL A  38
LYS A  53
None
0.46A25.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens)
4 / 7GLY A 252
GLY A 254
VAL A 259
LYS A 274
BI1  A1000 (-3.6A)
None
BI1  A1000 (-4.2A)
BI1  A1000 (-3.5A)
0.37A34.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens)
4 / 7GLY A  20
GLY A  22
VAL A  27
LYS A  42
None
0.33A27.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3
(Homo
sapiens)
4 / 7GLY A 163
GLY A 165
VAL A 170
LYS A 186
None
0.43A23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens)
4 / 7GLY A 274
GLY A 276
VAL A 281
LEU A 297
H8H  A 534 ( 3.8A)
None
H8H  A 534 (-4.4A)
None
0.49A22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens)
4 / 7GLY A 252
GLY A 254
VAL A 259
LYS A 273
None
None
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.8A)
0.46A23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1
(Homo
sapiens)
4 / 7GLY A  56
GLY A  58
VAL A  63
LYS A  78
None
0.29A28.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1
(Homo
sapiens)
4 / 7GLY A 249
GLY A 251
VAL A 256
LYS A 271
None
None
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.6A)
0.43A24.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
2i0e PROTEIN KINASE
C-BETA II
(Homo
sapiens)
5 / 7GLY A 349
GLY A 351
VAL A 356
LYS A 371
LEU A 373
PDS  A 901 ( 3.7A)
None
PDS  A 901 (-4.2A)
PDS  A 901 ( 4.5A)
None
0.75A36.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G
(Homo
sapiens)
5 / 7GLY A  30
GLY A  32
PHE A  34
VAL A  37
LYS A  52
None
None
None
J60  A1305 (-4.8A)
EDO  A1304 ( 2.9A)
0.33A30.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D
(Homo
sapiens)
4 / 7GLY A  30
GLY A  32
VAL A  37
LYS A  52
QPP  A1314 ( 3.7A)
None
QPP  A1314 ( 4.6A)
None
0.20A31.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens)
5 / 7GLY A  83
GLY A  85
VAL A  90
LYS A 105
LEU A 107
ANP  A1480 ( 4.3A)
ANP  A1480 ( 3.8A)
None
ANP  A1480 (-3.4A)
None
0.47A35.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN
(Homo
sapiens)
4 / 7GLY A 491
GLY A 493
VAL A 498
LYS A 511
5ID  A1800 (-3.5A)
None
5ID  A1800 ( 4.5A)
IOD  A1799 (-3.2A)
0.45A21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens)
4 / 7GLY A  53
GLY A  55
VAL A  60
LYS A  75
DKI  A1338 (-3.3A)
None
DKI  A1338 (-4.2A)
None
0.31A29.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens)
5 / 7GLY C  56
GLY C  58
SER C  59
VAL C  63
LYS C  78
ANP  C   2 (-3.3A)
ANP  C   2 (-3.0A)
None
ANP  C   2 (-4.2A)
ANP  C   2 (-3.6A)
0.89A28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3
(Homo
sapiens)
4 / 7GLY A  20
GLY A  22
VAL A  27
LYS A  42
4RB  A 401 (-3.6A)
None
4RB  A 401 ( 4.4A)
4RB  A 401 ( 2.8A)
0.37A26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK
(Homo
sapiens)
4 / 7GLY A  19
GLY A  21
VAL A  26
LYS A  41
None
None
3AM  A 338 ( 4.1A)
3AM  A 338 (-2.9A)
0.22A28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9
(Homo
sapiens)
4 / 7GLY A  33
GLY A  35
VAL A  40
LYS A  55
35F  A   1 ( 4.8A)
None
35F  A   1 ( 4.8A)
35F  A   1 ( 4.6A)
0.32A26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens)
4 / 7GLY A 834
GLY A 836
VAL A 841
LYS A 861
None
None
8ST  A2001 ( 4.6A)
8ST  A2001 (-4.0A)
0.48A23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens)
4 / 7GLY A 695
GLY A 697
VAL A 702
LYS A 721
ITI  A   1 ( 4.8A)
None
ITI  A   1 (-4.8A)
ITI  A   1 (-2.6A)
0.44A22.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens)
5 / 7GLY A  50
GLY A  52
SER A  53
VAL A  57
LYS A  72
XFE  A 351 ( 4.0A)
None
None
XFE  A 351 ( 4.5A)
None
0.69A94.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens)
5 / 7GLY A  50
GLY A  52
VAL A  57
LYS A  72
LEU A  74
XFE  A 351 ( 4.0A)
None
XFE  A 351 ( 4.5A)
None
None
0.48A94.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens)
4 / 7GLY A 209
GLY A 211
VAL A 216
LYS A 229
None
None
LDN  A 600 (-4.5A)
LDN  A 600 (-4.0A)
0.35A21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens)
4 / 7GLY A 193
VAL A 200
LYS A 215
LEU A 217
AMP  A 577 ( 3.7A)
AMP  A 577 (-4.3A)
AMP  A 577 (-2.8A)
None
0.44A26.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
3o96 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens)
5 / 7GLY A 157
GLY A 159
VAL A 164
LYS A 179
LEU A 181
GLY  A 157 ( 0.0A)
GLY  A 159 ( 0.0A)
VAL  A 164 ( 0.6A)
LYS  A 179 ( 0.0A)
LEU  A 181 ( 0.6A)
0.38A34.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
3qfv CDC42BPB PROTEIN
(Homo
sapiens)
4 / 7GLY A  83
VAL A  90
LYS A 105
LEU A 107
NM7  A 416 (-3.0A)
NM7  A 416 (-3.7A)
EDO  A 417 (-3.5A)
EDO  A 417 (-4.6A)
0.45A33.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens)
5 / 7GLY A 362
GLY A 364
SER A 365
VAL A 369
LYS A 384
07U  A   1 ( 4.2A)
None
None
07U  A   1 (-4.8A)
07U  A   1 (-3.0A)
0.83A39.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens)
5 / 7GLY A 362
GLY A 364
VAL A 369
LYS A 384
LEU A 386
07U  A   1 ( 4.2A)
None
07U  A   1 (-4.8A)
07U  A   1 (-3.0A)
None
0.46A39.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens)
4 / 7GLY A  11
GLY A  13
VAL A  18
LYS A  33
38R  A 350 ( 3.9A)
None
38R  A 350 ( 4.8A)
38R  A 350 (-2.9A)
0.29A31.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1
(Homo
sapiens)
4 / 7GLY A  11
GLY A  13
VAL A  18
LYS A  33
D15  A 500 (-3.8A)
D15  A 500 (-3.6A)
D15  A 500 (-4.6A)
D15  A 500 ( 4.1A)
0.30A24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens)
4 / 7GLY A 215
GLY A 217
VAL A 222
LYS A 235
None
None
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.5A)
0.34A21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1
(Homo
sapiens)
4 / 7GLY A 617
GLY A 619
VAL A 624
LYS A 655
None
None
DI1  A1000 (-4.8A)
DI1  A1000 (-3.9A)
0.31A24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens)
4 / 7GLY A  16
GLY A  18
VAL A  23
LYS A  38
BX7  A 401 ( 3.7A)
BX7  A 401 (-3.5A)
BX7  A 401 (-4.4A)
BX7  A 401 ( 4.0A)
0.38A26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens)
4 / 7GLY A  16
GLY A  18
VAL A  23
LYS A  38
BX7  A 401 ( 3.8A)
BX7  A 401 (-3.7A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.5A)
0.32A26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
4f99 CELL DIVISION CYCLE
7-RELATED PROTEIN
KINASE
(Homo
sapiens)
4 / 7GLY A  65
GLY A  67
VAL A  72
LYS A  90
ADP  A 601 ( 3.8A)
ADP  A 601 (-3.7A)
ADP  A 601 (-4.0A)
ADP  A 601 (-2.6A)
0.35A26.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens)
5 / 7GLY A 157
GLY A 159
VAL A 164
LYS A 179
LEU A 181
GOL  A 505 ( 3.4A)
0XZ  A 501 (-4.1A)
0XZ  A 501 (-4.5A)
GOL  A 503 ( 2.8A)
GOL  A 503 (-4.9A)
0.39A38.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3
(Homo
sapiens)
4 / 7GLY A 479
GLY A 481
VAL A 486
LYS A 508
ACP  A 801 (-3.4A)
ACP  A 801 (-3.6A)
ACP  A 801 (-4.2A)
ACP  A 801 (-2.7A)
0.31A25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens)
5 / 7GLY A 198
GLY A 200
VAL A 205
LYS A 220
LEU A 222
29X  A 702 ( 4.1A)
29X  A 702 (-3.6A)
29X  A 702 (-4.7A)
29X  A 702 (-3.6A)
None
0.52A25.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens)
4 / 7GLY A 628
GLY A 630
VAL A 635
LEU A 652
None
0.42A37.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1
(Homo
sapiens)
5 / 7GLY A 228
GLY A 230
SER A 231
VAL A 235
LEU A 252
None
0.41A25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens)
5 / 7GLY A 387
GLY A 389
SER A 390
LYS A 409
LEU A 411
PZW  A 801 ( 3.8A)
None
None
None
None
1.10A37.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens)
5 / 7GLY A 387
GLY A 389
VAL A 394
LYS A 409
LEU A 411
PZW  A 801 ( 3.8A)
None
PZW  A 801 (-4.6A)
None
None
0.54A37.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
4ra4 PROTEIN KINASE C
(Homo
sapiens)
5 / 7GLY A 346
GLY A 348
SER A 349
VAL A 353
LEU A 370
3KZ  A 701 (-3.3A)
None
None
3KZ  A 701 (-3.9A)
None
0.71A36.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
4ra4 PROTEIN KINASE C
(Homo
sapiens)
5 / 7GLY A 346
SER A 349
VAL A 353
LYS A 368
LEU A 370
3KZ  A 701 (-3.3A)
None
3KZ  A 701 (-3.9A)
3KZ  A 701 ( 4.7A)
None
0.70A36.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens)
5 / 7GLY A  25
PHE A  29
VAL A  32
LYS A  47
LEU A  49
STU  A 601 (-3.5A)
None
STU  A 601 ( 4.8A)
STU  A 601 ( 3.7A)
None
1.13A23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens)
4 / 7GLY A 193
VAL A 200
LYS A 215
LEU A 217
SGV  A 601 (-3.4A)
SGV  A 601 ( 4.6A)
SGV  A 601 ( 4.2A)
None
0.48A26.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens)
4 / 7GLY A 105
GLY A 107
VAL A 112
LEU A 129
ATP  A 501 (-3.5A)
ATP  A 501 (-3.2A)
ATP  A 501 (-4.0A)
None
0.47A84.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens)
4 / 7GLY A 105
VAL A 112
LYS A 127
LEU A 129
ATP  A 501 (-3.5A)
ATP  A 501 (-4.0A)
ATP  A 501 (-2.6A)
None
0.27A84.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens)
4 / 7GLY A 617
GLY A 619
VAL A 624
LYS A 644
None
None
P30  A1001 ( 4.8A)
P30  A1001 ( 4.0A)
0.48A24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K
(Homo
sapiens)
4 / 7GLY A 470
GLY A 472
VAL A 477
LYS A 490
4CV  A 801 ( 3.9A)
None
None
4CV  A 801 (-3.9A)
0.36A24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
4ylj DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 1A
(Homo
sapiens)
4 / 7GLY A 166
GLY A 168
SER A 169
VAL A 173
4E1  A 505 (-3.5A)
4E1  A 505 ( 4.9A)
None
4E1  A 505 (-4.5A)
0.41A25.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens)
4 / 7GLY A  63
GLY A  65
VAL A  70
LYS A  85
5RC  A4000 ( 4.3A)
5RC  A4000 ( 3.9A)
5RC  A4000 (-4.6A)
5RC  A4000 (-2.8A)
0.34A32.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF
(Homo
sapiens)
4 / 7GLY A 464
GLY A 466
VAL A 471
LYS A 483
None
None
5XJ  A 801 (-4.6A)
5XJ  A 801 (-3.8A)
0.27A25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens)
4 / 7GLY A 731
GLY A 733
VAL A 738
LYS A 758
PP1  A2012 ( 3.9A)
None
PP1  A2012 (-4.4A)
PP1  A2012 (-4.1A)
0.47A26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens)
4 / 7GLY A  28
GLY A  30
VAL A  35
LYS A  52
6A7  A 401 (-3.6A)
None
6A7  A 401 ( 4.5A)
6A7  A 401 ( 2.9A)
0.48A25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens)
4 / 7GLY A 719
GLY A 721
VAL A 726
LYS A 745
6HJ  A1101 ( 4.2A)
None
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-4.2A)
0.48A24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2
(Homo
sapiens)
5 / 7GLY A 156
GLY A 158
SER A 159
VAL A 163
LYS A 178
7A7  A 501 (-3.2A)
None
None
7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
0.68A26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3
(Homo
sapiens)
4 / 7GLY A 154
GLY A 156
VAL A 161
LEU A 178
None
0.45A26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens)
4 / 7GLY A  45
GLY A  47
VAL A  52
LYS A  67
None
None
7LK  A 401 (-4.9A)
None
0.46A23.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens)
5 / 7GLY A  99
GLY A 101
VAL A 106
LYS A 121
LEU A 123
None
0.41A34.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens)
5 / 7GLY A 198
GLY A 200
VAL A 205
LYS A 220
LEU A 222
QRW  A 601 ( 4.5A)
QRW  A 601 (-3.6A)
QRW  A 601 (-4.7A)
QRW  A 601 (-3.0A)
QRW  A 601 (-4.3A)
0.63A26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens)
5 / 7GLY A 117
GLY A 119
SER A 120
VAL A 124
LYS A 139
H8H  A 401 ( 3.7A)
None
None
H8H  A 401 (-4.7A)
H8H  A 401 (-4.9A)
0.80A26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
5y86 DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 3
(Homo
sapiens)
5 / 7GLY A 216
GLY A 218
SER A 219
VAL A 223
LYS A 238
None
PO4  A 602 (-3.5A)
PO4  A 602 (-2.7A)
HRM  A 601 ( 4.9A)
HRM  A 601 (-3.3A)
0.65A12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
6b4w DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens)
4 / 7GLY A 532
GLY A 534
VAL A 539
LYS A 553
CQ7  A 801 ( 4.0A)
None
CQ7  A 801 ( 4.8A)
CQ7  A 801 (-3.2A)
0.39A24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens)
5 / 7GLY A 219
GLY A 221
VAL A 226
LYS A 239
LEU A 241
DL1  A 601 ( 4.1A)
None
None
DL1  A 601 ( 4.1A)
None
0.69A11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
6bql CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2
(Homo
sapiens)
6 / 7GLY A 172
GLY A 174
SER A 175
VAL A 179
LYS A 194
LEU A 196
BI9  A 501 (-3.6A)
None
ACT  A 504 (-3.3A)
BI9  A 501 ( 4.8A)
NH4  A 506 ( 4.4A)
None
0.60A13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
6c0t CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens)
6 / 7GLY A 367
GLY A 369
PHE A 371
VAL A 374
LYS A 390
LEU A 392
EE4  A 701 (-3.9A)
EE4  A 701 (-3.4A)
EE4  A 701 (-3.0A)
EE4  A 701 (-4.4A)
DMS  A 702 (-3.5A)
EE4  A 701 ( 4.6A)
0.51A18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1
(Homo
sapiens)
5 / 7GLY A  67
GLY A  69
PHE A  71
VAL A  74
LYS A  89
None
0.71A13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
6ccf CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 1
(Homo
sapiens)
5 / 7GLY A 135
GLY A 137
VAL A 142
LYS A 157
LEU A 159
H1N  A 501 ( 3.8A)
None
H1N  A 501 (-4.4A)
H1N  A 501 (-2.8A)
None
0.44A13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2
(Homo
sapiens)
4 / 7GLY A 170
GLY A 172
VAL A 177
LYS A 193
3NG  A 501 (-3.5A)
3NG  A 501 ( 4.5A)
3NG  A 501 ( 4.4A)
3NG  A 501 (-3.0A)
0.46Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens)
4 / 7GLY A 168
GLY A 170
VAL A 175
LYS A 191
3NG  A 501 (-3.5A)
3NG  A 501 ( 4.9A)
3NG  A 501 ( 4.3A)
3NG  A 501 (-2.7A)
0.34Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
1gng GLYCOGEN SYNTHASE
KINASE-3 BETA
(Homo
sapiens)
6 / 7GLY A  63
GLY A  65
SER A  66
VAL A  70
LYS A  85
ASP A 200
None
0.56A23.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE
(Homo
sapiens)
4 / 7GLY A 159
GLY A 161
VAL A 166
LYS A 181
None
0.37A39.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
1nxk MAP KINASE-ACTIVATED
PROTEIN KINASE 2
(Homo
sapiens)
4 / 7GLY A  71
VAL A  78
LYS A  93
ASP A 207
STU  A 401 (-3.6A)
STU  A 401 (-4.7A)
STU  A 401 ( 4.5A)
STU  A 401 (-3.6A)
0.42A28.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
1tki TITIN
(Homo
sapiens)
4 / 7GLY A  31
GLY A  33
VAL A  38
LYS A  53
None
0.39A25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens)
4 / 7GLY A 345
GLY A 347
VAL A 352
ASP A 479
STU  A 100 (-3.3A)
None
STU  A 100 (-4.8A)
STU  A 100 (-3.5A)
0.38A22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens)
4 / 7GLY A 345
GLY A 347
VAL A 352
LYS A 369
STU  A 100 (-3.3A)
None
STU  A 100 (-4.8A)
STU  A 100 ( 4.7A)
0.39A22.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens)
4 / 7GLY A 252
GLY A 254
VAL A 259
LYS A 274
BI1  A1000 (-3.6A)
None
BI1  A1000 (-4.2A)
BI1  A1000 (-3.5A)
0.30A34.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
2a1a INTERFERON-INDUCED,
DOUBLE-STRANDED
RNA-ACTIVATED
PROTEIN KINASE
(Homo
sapiens)
5 / 7GLY B 274
GLY B 276
VAL B 281
LYS B 296
ASP B 432
None
0.71A25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens)
4 / 7GLY A  20
GLY A  22
VAL A  27
LYS A  42
None
0.42A27.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN
(Homo
sapiens)
4 / 7GLY X  18
VAL X  25
LYS X  39
ASP X 148
STU  X 902 ( 3.7A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.6A)
0.35A23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3
(Homo
sapiens)
5 / 7GLY A 163
GLY A 165
VAL A 170
LYS A 186
ASP A 320
None
0.64A23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens)
4 / 7GLY A 252
GLY A 254
VAL A 259
LYS A 273
None
None
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.8A)
0.39A23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1
(Homo
sapiens)
4 / 7GLY A  56
GLY A  58
VAL A  63
LYS A  78
None
0.28A28.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1
(Homo
sapiens)
4 / 7GLY A 249
GLY A 251
VAL A 256
LYS A 271
None
None
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.6A)
0.48A24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens)
4 / 7GLY A  39
GLY A  41
VAL A  46
ASP A 182
HB1  A1289 (-3.1A)
None
HB1  A1289 (-3.6A)
HB1  A1289 (-4.2A)
0.45A24.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G
(Homo
sapiens)
4 / 7GLY A  30
GLY A  32
VAL A  37
LYS A  52
None
None
J60  A1305 (-4.8A)
EDO  A1304 ( 2.9A)
0.31A30.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D
(Homo
sapiens)
4 / 7GLY A  30
GLY A  32
VAL A  37
LYS A  52
QPP  A1314 ( 3.7A)
None
QPP  A1314 ( 4.6A)
None
0.30A31.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens)
4 / 7GLY A  83
GLY A  85
VAL A  90
LYS A 105
ANP  A1480 ( 4.3A)
ANP  A1480 ( 3.8A)
None
ANP  A1480 (-3.4A)
0.41A35.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens)
4 / 7GLY A  53
GLY A  55
VAL A  60
LYS A  75
DKI  A1338 (-3.3A)
None
DKI  A1338 (-4.2A)
None
0.35A29.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens)
5 / 7GLY C  56
GLY C  58
SER C  59
VAL C  63
LYS C  78
ANP  C   2 (-3.3A)
ANP  C   2 (-3.0A)
None
ANP  C   2 (-4.2A)
ANP  C   2 (-3.6A)
0.79A28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens)
4 / 7GLY A 306
GLY A 308
VAL A 313
ASP A 463
770  A 901 ( 4.6A)
None
770  A 901 ( 4.7A)
770  A 901 (-3.8A)
0.48A23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3
(Homo
sapiens)
5 / 7GLY A  20
GLY A  22
VAL A  27
LYS A  42
ASP A 161
4RB  A 401 (-3.6A)
None
4RB  A 401 ( 4.4A)
4RB  A 401 ( 2.8A)
GOL  A 503 ( 3.1A)
0.78A26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK
(Homo
sapiens)
4 / 7GLY A  19
GLY A  21
VAL A  26
LYS A  41
None
None
3AM  A 338 ( 4.1A)
3AM  A 338 (-2.9A)
0.25A28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens)
5 / 7GLY A 202
GLY A 204
VAL A 209
LYS A 222
ASP A 332
None
0.76A23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9
(Homo
sapiens)
4 / 7GLY A  33
GLY A  35
VAL A  40
LYS A  55
35F  A   1 ( 4.8A)
None
35F  A   1 ( 4.8A)
35F  A   1 ( 4.6A)
0.33A26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens)
4 / 7GLY A 211
VAL A 218
LYS A 231
ASP A 350
LDN  A   1 ( 4.7A)
LDN  A   1 ( 4.8A)
None
LDN  A   1 (-3.9A)
0.41A21.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens)
5 / 7GLY A  50
GLY A  52
SER A  53
VAL A  57
LYS A  72
XFE  A 351 ( 4.0A)
None
None
XFE  A 351 ( 4.5A)
None
0.70A94.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens)
4 / 7GLY A  50
VAL A  57
LYS A  72
ASP A 184
XFE  A 351 ( 4.0A)
XFE  A 351 ( 4.5A)
None
None
0.39A94.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens)
4 / 7GLY A 209
GLY A 211
VAL A 216
LYS A 229
None
None
LDN  A 600 (-4.5A)
LDN  A 600 (-4.0A)
0.25A21.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
3o96 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens)
4 / 7GLY A 157
GLY A 159
VAL A 164
LYS A 179
GLY  A 157 ( 0.0A)
GLY  A 159 ( 0.0A)
VAL  A 164 ( 0.6A)
LYS  A 179 ( 0.0A)
0.41A34.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens)
4 / 7GLY A 727
VAL A 734
LYS A 753
ASP A 863
None
03Q  A   1 (-4.5A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.0A)
0.45A23.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens)
5 / 7GLY A 362
GLY A 364
SER A 365
VAL A 369
LYS A 384
07U  A   1 ( 4.2A)
None
None
07U  A   1 (-4.8A)
07U  A   1 (-3.0A)
0.72A39.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens)
5 / 7GLY A 362
GLY A 364
VAL A 369
LYS A 384
ASP A 497
07U  A   1 ( 4.2A)
None
07U  A   1 (-4.8A)
07U  A   1 (-3.0A)
07U  A   1 (-3.6A)
0.58A39.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens)
4 / 7GLY A 841
GLY A 843
VAL A 848
LYS A 868
4TT  A2001 ( 4.8A)
None
4TT  A2001 ( 4.5A)
None
0.44A22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
3vn9 DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6
(Homo
sapiens)
5 / 7GLY A  60
GLY A  62
VAL A  67
LYS A  82
ASP A 197
ANK  A 401 (-3.4A)
ANK  A 401 ( 4.9A)
ANK  A 401 (-4.3A)
ANK  A 401 (-2.4A)
MG  A 402 ( 2.8A)
1.04A26.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens)
5 / 7GLY A  11
GLY A  13
VAL A  18
LYS A  33
ASP A 143
38R  A 350 ( 3.9A)
None
38R  A 350 ( 4.8A)
38R  A 350 (-2.9A)
NA  A 353 ( 2.5A)
0.54A31.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1
(Homo
sapiens)
4 / 7GLY A  11
GLY A  13
VAL A  18
LYS A  33
D15  A 500 (-3.8A)
D15  A 500 (-3.6A)
D15  A 500 (-4.6A)
D15  A 500 ( 4.1A)
0.41A24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens)
4 / 7GLY A  20
GLY A  22
VAL A  27
LYS A  42
None
None
38R  A1000 ( 4.8A)
38R  A1000 (-3.4A)
0.44A25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens)
5 / 7GLY A 215
GLY A 217
VAL A 222
LYS A 235
ASP A 354
None
None
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.5A)
0.82A21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1
(Homo
sapiens)
4 / 7GLY A 617
GLY A 619
VAL A 624
LYS A 655
None
None
DI1  A1000 (-4.8A)
DI1  A1000 (-3.9A)
0.33A24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens)
4 / 7GLY A  16
GLY A  18
VAL A  23
LYS A  38
BX7  A 401 ( 3.8A)
BX7  A 401 (-3.7A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.5A)
0.42A26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
4f99 CELL DIVISION CYCLE
7-RELATED PROTEIN
KINASE
(Homo
sapiens)
4 / 7GLY A  65
GLY A  67
VAL A  72
LYS A  90
ADP  A 601 ( 3.8A)
ADP  A 601 (-3.7A)
ADP  A 601 (-4.0A)
ADP  A 601 (-2.6A)
0.39A26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A
(Homo
sapiens)
4 / 7GLY A  30
GLY A  32
SER A  33
ASP A 164
STU  A 401 (-3.3A)
None
None
STU  A 401 ( 3.9A)
0.48A29.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens)
5 / 7GLY A 157
GLY A 159
VAL A 164
LYS A 179
ASP A 292
GOL  A 505 ( 3.4A)
0XZ  A 501 (-4.1A)
0XZ  A 501 (-4.5A)
GOL  A 503 ( 2.8A)
0XZ  A 501 ( 3.4A)
0.66A38.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3
(Homo
sapiens)
5 / 7GLY A 479
GLY A 481
VAL A 486
LYS A 508
ASP A 635
ACP  A 801 (-3.4A)
ACP  A 801 (-3.6A)
ACP  A 801 (-4.2A)
ACP  A 801 (-2.7A)
MG  A 802 ( 3.0A)
0.69A25.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
4otd SERINE/THREONINE-PRO
TEIN KINASE N1
(Homo
sapiens)
5 / 7GLY A 628
GLY A 630
VAL A 635
LYS A 650
ASP A 764
None
0.64A37.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1
(Homo
sapiens)
5 / 7GLY A 228
GLY A 230
SER A 231
PHE A 232
VAL A 235
None
0.59A25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens)
5 / 7GLY A 387
GLY A 389
SER A 390
VAL A 394
LYS A 409
PZW  A 801 ( 3.8A)
None
None
PZW  A 801 (-4.6A)
None
0.82A37.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
4ra4 PROTEIN KINASE C
(Homo
sapiens)
5 / 7GLY A 346
GLY A 348
SER A 349
VAL A 353
LYS A 368
3KZ  A 701 (-3.3A)
None
None
3KZ  A 701 (-3.9A)
3KZ  A 701 ( 4.7A)
0.64A36.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens)
4 / 7GLY A  25
VAL A  32
LYS A  47
ASP A 159
STU  A 601 (-3.5A)
STU  A 601 ( 4.8A)
STU  A 601 ( 3.7A)
STU  A 601 (-3.7A)
0.46A23.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens)
4 / 7GLY A 105
VAL A 112
LYS A 127
ASP A 239
ATP  A 501 (-3.5A)
ATP  A 501 (-4.0A)
ATP  A 501 (-2.6A)
ZN  A 503 (-1.9A)
0.43A84.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens)
4 / 7GLY A 617
GLY A 619
VAL A 624
LYS A 644
None
None
P30  A1001 ( 4.8A)
P30  A1001 ( 4.0A)
0.42A24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K
(Homo
sapiens)
5 / 7GLY A 470
GLY A 472
VAL A 477
LYS A 490
ASP A 606
4CV  A 801 ( 3.9A)
None
None
4CV  A 801 (-3.9A)
4CV  A 801 (-3.5A)
0.48A24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
4ylj DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 1A
(Homo
sapiens)
5 / 7GLY A 166
GLY A 168
SER A 169
VAL A 173
LYS A 188
4E1  A 505 (-3.5A)
4E1  A 505 ( 4.9A)
None
4E1  A 505 (-4.5A)
4E1  A 505 (-2.7A)
0.55A25.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens)
5 / 7GLY A  63
GLY A  65
VAL A  70
LYS A  85
ASP A 196
5RC  A4000 ( 4.3A)
5RC  A4000 ( 3.9A)
5RC  A4000 (-4.6A)
5RC  A4000 (-2.8A)
5RC  A4000 (-3.6A)
0.57A32.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF
(Homo
sapiens)
5 / 7GLY A 464
GLY A 466
VAL A 471
LYS A 483
ASP A 594
None
None
5XJ  A 801 (-4.6A)
5XJ  A 801 (-3.8A)
None
0.52A25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens)
4 / 7GLY A 731
GLY A 733
VAL A 738
LYS A 758
PP1  A2012 ( 3.9A)
None
PP1  A2012 (-4.4A)
PP1  A2012 (-4.1A)
0.44A26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens)
4 / 7GLY A  28
GLY A  30
VAL A  35
LYS A  52
6A7  A 401 (-3.6A)
None
6A7  A 401 ( 4.5A)
6A7  A 401 ( 2.9A)
0.40A25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens)
4 / 7GLY A  23
VAL A  30
LYS A  45
ASP A 154
None
6G2  A 901 ( 4.9A)
6G2  A 901 ( 3.9A)
6G2  A 901 (-3.4A)
0.39A25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens)
4 / 7GLY A 719
GLY A 721
VAL A 726
LYS A 745
6HJ  A1101 ( 4.2A)
None
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-4.2A)
0.41A24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2
(Homo
sapiens)
5 / 7GLY A 156
GLY A 158
SER A 159
VAL A 163
LYS A 178
7A7  A 501 (-3.2A)
None
None
7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
0.63A26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2
(Homo
sapiens)
5 / 7GLY A 156
GLY A 158
VAL A 163
LYS A 178
ASP A 295
7A7  A 501 (-3.2A)
None
7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 (-3.2A)
0.51A26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens)
5 / 7GLY A  45
GLY A  47
VAL A  52
LYS A  67
ASP A 186
None
None
7LK  A 401 (-4.9A)
None
None
0.85A23.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens)
5 / 7GLY A  99
GLY A 101
VAL A 106
LYS A 121
ASP A 232
None
0.85A34.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens)
5 / 7GLY A 117
GLY A 119
SER A 120
VAL A 124
LYS A 139
H8H  A 401 ( 3.7A)
None
None
H8H  A 401 (-4.7A)
H8H  A 401 (-4.9A)
0.66A26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens)
4 / 7GLY A  87
GLY A  89
VAL A  94
LYS A 109
EMH  A 705 ( 3.9A)
None
EMH  A 705 ( 4.4A)
EMH  A 705 ( 4.8A)
0.49A10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
5y86 DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 3
(Homo
sapiens)
5 / 7GLY A 216
GLY A 218
VAL A 223
LYS A 238
ASP A 355
None
PO4  A 602 (-3.5A)
HRM  A 601 ( 4.9A)
HRM  A 601 (-3.3A)
HRM  A 601 (-4.7A)
0.72A12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
6b4w DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens)
4 / 7GLY A 532
GLY A 534
VAL A 539
LYS A 553
CQ7  A 801 ( 4.0A)
None
CQ7  A 801 ( 4.8A)
CQ7  A 801 (-3.2A)
0.43A24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
6bql CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2
(Homo
sapiens)
5 / 7GLY A 172
GLY A 174
SER A 175
VAL A 179
LYS A 194
BI9  A 501 (-3.6A)
None
ACT  A 504 (-3.3A)
BI9  A 501 ( 4.8A)
NH4  A 506 ( 4.4A)
0.46A13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
6c0t CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens)
4 / 7GLY A 367
GLY A 369
VAL A 374
LYS A 390
EE4  A 701 (-3.9A)
EE4  A 701 (-3.4A)
EE4  A 701 (-4.4A)
DMS  A 702 (-3.5A)
0.29A18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1
(Homo
sapiens)
5 / 7GLY A  67
GLY A  69
PHE A  71
VAL A  74
LYS A  89
None
0.69A13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1
(Homo
sapiens)
5 / 7GLY A  67
GLY A  69
VAL A  74
LYS A  89
ASP A 200
None
0.51A13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
6ccf CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 1
(Homo
sapiens)
5 / 7GLY A 135
GLY A 137
VAL A 142
LYS A 157
ASP A 293
H1N  A 501 ( 3.8A)
None
H1N  A 501 (-4.4A)
H1N  A 501 (-2.8A)
H1N  A 501 (-3.5A)
0.78A13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2
(Homo
sapiens)
4 / 7GLY A 170
GLY A 172
VAL A 177
LYS A 193
3NG  A 501 (-3.5A)
3NG  A 501 ( 4.5A)
3NG  A 501 ( 4.4A)
3NG  A 501 (-3.0A)
0.34Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1
(Homo
sapiens)
5 / 7GLY A 168
GLY A 170
VAL A 175
LYS A 191
ASP A 325
None
None
None
EAQ  A 501 (-3.2A)
EAQ  A 501 (-4.6A)
0.70Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4
(Homo
sapiens)
5 / 7GLY A 168
GLY A 170
VAL A 175
LYS A 191
ASP A 325
3NG  A 501 (-3.5A)
3NG  A 501 ( 4.9A)
3NG  A 501 ( 4.3A)
3NG  A 501 (-2.7A)
3NG  A 501 (-4.3A)
0.68Aundetectable