POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		2a38 TITIN
(Homo
sapiens)		3 / 3ASN A 105
ALA A 102
ASN A 180
None
0.78A18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		2pso STAR-RELATED LIPID
TRANSFER PROTEIN 13
(Homo
sapiens)		3 / 3ASN A 936
ALA A1095
ASN A1099
None
0.82A18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		2ver AFIMBRIAL ADHESIN
AFA-III
ARCINOEMBRYONIC
ANTIGEN-RELATED CELL
ADHESION MOLECULE 5
(Escherichia
coli;
Homo
sapiens)		3 / 3ASN A  87
ALA A  76
ASN N  42
None
0.81A21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		3vzb SPHINGOSINE KINASE 1
(Homo
sapiens)		3 / 3ASN A  22
ALA A 110
ASN A 114
None
0.79A13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		4djh KAPPA-TYPE OPIOID
RECEPTOR, LYSOZYME
(Homo
sapiens;
Escherichia
virus
T4)		3 / 3ASN A  95
ALA A 175
ASN A 179
None
0.80A14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		4fys AMINOPEPTIDASE N
(Homo
sapiens)		3 / 3ASN A 900
ALA A 904
ASN A 868
None
0.66A8.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1N4F_A_ASRA141_0
(LYSOZYME C)		1di4 LYSOZYME C
(Homo
sapiens)		5 / 6ASN A  66
ASP A  67
GLY A  68
THR A  70
PRO A  71
None
0.70A60.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		1icf PROTEIN (CATHEPSIN
L: HEAVY CHAIN)
(Homo
sapiens)		4 / 6ASN A 108
GLY A  81
PRO A 102
SER A 105
None
0.85A19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		1yck PEPTIDOGLYCAN
RECOGNITION PROTEIN
(Homo
sapiens)		4 / 6ASN A  75
GLY A  94
PRO A 103
SER A 105
None
1.00A23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		1yz1 TRANSLATIONALLY
CONTROLLED TUMOR
PROTEIN
(Homo
sapiens)		4 / 6ASP A 154
GLY A 155
THR A 157
PRO A 158
None
0.71A19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens)		4 / 6ASP A  28
GLY A  29
PRO A  31
SER A  32
None
0.92A20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		2jfd FATTY ACID SYNTHASE
(Homo
sapiens)		4 / 6ASP A 591
GLY A 592
PRO A 707
SER A 730
None
0.85A14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		2pxx UNCHARACTERIZED
PROTEIN MGC2408
(Homo
sapiens)		4 / 6ASP A 134
GLY A 131
THR A 175
SER A 173
None
SAH  A 301 (-4.1A)
None
None
0.93A20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		2q9g CYTOCHROME P450 46A1
(Homo
sapiens)		4 / 6ASP A 173
GLY A 174
THR A 176
PRO A 177
None
0.76A13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		2rgn RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 25
(Homo
sapiens)		4 / 6ASN B 422
ASP B 426
PRO B 451
SER B 454
None
0.90A15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		2w2j CARBONIC
ANHYDRASE-RELATED
PROTEIN
(Homo
sapiens)		4 / 6ASN A  84
ASP A  85
GLY A  86
THR A  88
None
0.67A18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		3ctt MALTASE-GLUCOAMYLASE
(Homo
sapiens)		4 / 6ASP A 396
GLY A 397
THR A 399
PRO A 400
None
NAG  A2002 (-4.7A)
None
None
0.88A9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		3lpp SUCRASE-ISOMALTASE
(Homo
sapiens)		4 / 6ASP A 425
GLY A 426
THR A 428
PRO A 429
None
NAG  A3001 (-4.2A)
None
None
0.84A8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		4q80 SERINE PROTEASE 57
(Homo
sapiens)		5 / 6ASP A 222
GLY A 221
THR A 224
PRO A 225
SER A 216
None
None
None
None
2YS  A 304 (-3.7A)
1.28A20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		4z2a FURIN
(Homo
sapiens)		4 / 6ASP A 306
GLY A 307
THR A 309
SER A 335
None
0.76A16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		5lb3 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens)		4 / 6ASP B 353
GLY B 354
PRO B 356
SER B 357
None
0.78A15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens)		4 / 6ASP A 173
GLY A 174
THR A 176
PRO A 177
None
0.36A13.70