POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		1elv COMPLEMENT C1S
COMPONENT
(Homo
sapiens)		6 / 8ASP A 611
SER A 612
SER A 617
VAL A 638
GLY A 641
GLY A 648
None
None
SO4  A2001 ( 2.7A)
None
None
None
0.37A24.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		1fq3 GRANZYME B
(Homo
sapiens)		4 / 8SER A 190
SER A 195
VAL A 213
GLY A 216
None
SO4  A 800 (-2.4A)
None
None
0.61A32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA
(Homo
sapiens)		6 / 8ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
0G6  A   1 (-2.8A)
0G6  A   1 (-2.8A)
0G6  A   1 (-1.4A)
None
0G6  A   1 (-3.9A)
0G6  A   1 (-3.3A)
0.38A34.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		1h4w TRYPSIN IVA
(Homo
sapiens)		6 / 8ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
BEN  A 250 (-2.9A)
BEN  A 250 (-2.9A)
BEN  A 250 (-3.6A)
None
BEN  A 250 (-3.9A)
BEN  A 250 (-3.3A)
0.32A38.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		1o5f SERINE PROTEASE
HEPSIN
(Homo
sapiens)		6 / 8ASP H 189
GLN H 192
SER H 195
VAL H 213
GLY H 216
GLY H 226
CR9  H 256 (-2.4A)
CR9  H 256 ( 4.4A)
CR9  H 256 (-1.5A)
CR9  H 256 (-4.3A)
CR9  H 256 ( 3.8A)
CR9  H 256 (-3.0A)
0.43A37.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		1orf GRANZYME A
(Homo
sapiens)		5 / 8ASP A 189
SER A 190
SER A 195
GLY A 216
GLY A 226
0G6  A   1 (-2.9A)
0G6  A   1 (-2.9A)
0G6  A   1 (-1.3A)
0G6  A   1 (-3.3A)
0G6  A   1 (-3.5A)
0.36A29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens)		6 / 8ASP A 627
SER A 628
SER A 633
VAL A 653
GLY A 656
GLY A 667
 NA  A 800 ( 4.6A)
GOL  A 701 (-3.4A)
GOL  A 701 (-3.0A)
GOL  A 701 (-4.9A)
GOL  A 701 ( 4.1A)
GOL  A 701 ( 4.0A)
0.46A26.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		1zlr COAGULATION FACTOR
XI
(Homo
sapiens)		4 / 8ASP A 189
SER A 195
GLY A 216
GLY A 226
368  A 901 (-2.8A)
368  A 901 (-1.4A)
368  A 901 (-3.6A)
368  A 901 (-3.5A)
0.43A34.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens)		4 / 8GLN A  86
GLY A 175
CYH A 503
GLY A 474
None
None
SF4  A1000 (-2.2A)
None
0.69A13.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		2ei8 COAGULATION FACTOR
X, HEAVY CHAIN
(Homo
sapiens)		5 / 8ASP A 189
GLN A 192
SER A 195
VAL A 213
GLY A 226
DT8  A 700 (-3.5A)
DT8  A 700 (-3.9A)
DT8  A 700 ( 3.9A)
DT8  A 700 ( 4.1A)
DT8  A 700 (-3.5A)
0.39A32.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		2ei8 COAGULATION FACTOR
X, HEAVY CHAIN
(Homo
sapiens)		5 / 8ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
DT8  A 700 (-3.5A)
DT8  A 700 ( 3.9A)
DT8  A 700 ( 4.1A)
DT8  A 700 (-3.5A)
DT8  A 700 (-3.5A)
0.38A32.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		2ik8 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(I),
ALPHA-1 SUBUNIT
(Homo
sapiens)		4 / 8SER A  44
SER A  47
GLY A 203
GLY A  40
GDP  A 401 (-3.6A)
MG  A 356 ( 1.9A)
ALF  A 355 (-3.3A)
None
0.72A20.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E
(Homo
sapiens)		5 / 8ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
BEN  A 245 (-3.0A)
BEN  A 245 (-3.3A)
None
BEN  A 245 ( 3.8A)
BEN  A 245 (-3.4A)
0.34A35.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		2pks THROMBIN HEAVY CHAIN
FRAGMENT
(Homo
sapiens)		5 / 8ASP C 229
SER C 235
VAL C 255
GLY C 258
GLY C 268
G44  C 101 (-2.6A)
G44  C 101 (-3.5A)
None
G44  C 101 (-3.3A)
G44  C 101 (-3.0A)
0.45A19.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		2psy KALLIKREIN-5
(Homo
sapiens)		6 / 8ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
None
0.43A35.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		2q3f RAS-RELATED
GTP-BINDING PROTEIN
D
(Homo
sapiens)		4 / 8SER A  54
SER A  57
GLY A 101
GLY A  50
GNP  A 401 (-3.5A)
MG  A 301 ( 2.1A)
GNP  A 401 (-3.2A)
None
0.69A19.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		2qy0 COMPLEMENT C1R
SUBCOMPONENT
(Homo
sapiens)		6 / 8ASP B 631
GLN B 634
SER B 637
VAL B 657
GLY B 660
GLY B 668
None
0.53A30.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR
(Homo
sapiens)		5 / 8ASP A 189
GLN A 192
SER A 195
GLY A 216
GLY A 226
None
0.56A38.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens)		5 / 8ASP U 189
SER U 190
VAL U 213
GLY U 216
GLY U 226
4PG  U 300 (-2.8A)
4PG  U 300 (-2.7A)
None
4PG  U 300 (-3.3A)
4PG  U 300 (-3.2A)
0.22A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		2wpm COAGULATION FACTOR
IXA HEAVY CHAIN
(Homo
sapiens)		5 / 8ASP S 189
SER S 190
SER S 195
GLY S 216
GLY S 226
None
0.32A30.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		2zec TRYPTASE BETA 2
(Homo
sapiens)		7 / 8ASP A 203
SER A 204
GLN A 206
SER A 209
VAL A 227
GLY A 230
GLY A 240
11N  A   1 (-2.6A)
11N  A   1 (-3.5A)
None
11N  A   1 (-3.3A)
None
11N  A   1 (-3.9A)
11N  A   1 (-3.6A)
0.43A35.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN
(Homo
sapiens)		5 / 8ASP H 189
SER H 195
VAL H 213
GLY H 216
GLY H 226
0G6  H   1 (-2.8A)
0G6  H   1 (-1.8A)
None
0G6  H   1 (-3.8A)
0G6  H   1 ( 3.9A)
0.49A35.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		3gov MASP-1
(Homo
sapiens)		4 / 8ASP B 640
SER B 646
VAL B 666
GLY B 679
None
0.51A30.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		3gov MASP-1
(Homo
sapiens)		4 / 8SER B 646
VAL B 666
GLY B 669
GLY B 679
None
0.51A30.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		3gym PROSTASIN
(Homo
sapiens)		5 / 8ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
None
0.48A36.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		3r3g THROMBIN HEAVY CHAIN
(Homo
sapiens)		5 / 8ASP B 189
SER B 195
VAL B 213
GLY B 216
GLY B 226
None
0.36A31.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		3w6o DYNAMIN-1-LIKE
PROTEIN
(Homo
sapiens)		4 / 8SER A  36
SER A  39
GLY A 149
GLY A  32
GCP  A 801 (-4.0A)
MG  A 802 ( 2.0A)
GCP  A 801 (-3.6A)
None
0.74A21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		3zjc GTPASE IMAP FAMILY
MEMBER 7
(Homo
sapiens)		4 / 8SER A  19
SER A  22
GLY A  66
GLY A  15
GNP  A1297 (-3.9A)
MG  A1296 ( 2.4A)
GNP  A1297 ( 4.3A)
None
0.65A21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens)		5 / 8ASP A 647
SER A 645
GLN A 588
GLY A 606
GLY A 625
None
1.26A17.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		4d9r COMPLEMENT FACTOR D
(Homo
sapiens)		4 / 8ASP A 189
SER A 195
VAL A 213
GLY A 226
None
0.30A32.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		4dgj ENTEROPEPTIDASE
CATALYTIC LIGHT
CHAIN
(Homo
sapiens)		4 / 8ASP A 181
SER A 182
GLY A 208
GLY A 218
None
0.26A34.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN
(Homo
sapiens)		5 / 8ASP H 627
SER H 628
VAL H 653
GLY H 656
GLY H 667
None
0.36A31.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3
(Homo
sapiens)		5 / 8ASP E 639
SER E 645
VAL E 665
GLY E 668
GLY E 680
None
0.35A30.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		4k8y KALLIKREIN-4
(Homo
sapiens)		6 / 8ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
None
0.41A33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		4r0i SUPPRESSOR OF
TUMORIGENICITY 14
PROTEIN
(Homo
sapiens)		7 / 8ASP A 189
SER A 190
GLN A 192
SER A 195
VAL A 213
GLY A 216
GLY A 226
3KM  A 900 (-2.9A)
3KM  A 900 (-2.9A)
None
3KM  A 900 (-3.6A)
None
3KM  A 900 (-3.4A)
3KM  A 900 (-3.2A)
0.40A33.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		4wwy TRYPSIN-1
(Homo
sapiens)		6 / 8ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
None
0.37A37.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		4ylq COAGULATION FACTOR
VII
(Homo
sapiens)		6 / 8ASP H 189
SER H 190
SER H 195
VAL H 213
GLY H 216
GLY H 226
0Z7  H 501 (-2.3A)
0Z7  H 501 (-2.3A)
0Z7  H 501 (-1.4A)
0Z7  H 501 ( 4.7A)
0Z7  H 501 (-3.4A)
0Z7  H 501 (-3.0A)
0.42A32.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens)		4 / 8ASP E 189
GLN E 192
GLY E 216
GLY E 226
None
0.45A44.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		5ms3 KALLIKREIN-8
(Homo
sapiens)		5 / 8ASP A 189
GLN A 192
SER A 195
GLY A 216
GLY A 226
None
0.61A22.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		5o32 COMPLEMENT FACTOR I
(Homo
sapiens)		4 / 8ASP I 519
VAL I 544
GLY I 547
GLY I 557
None
0.73A32.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens)		5 / 8ASP B 214
SER B 220
VAL B 240
GLY B 243
GLY B 253
0G6  B 501 (-2.9A)
0G6  B 501 (-1.3A)
None
0G6  B 501 (-3.7A)
0G6  B 501 (-3.6A)
0.32A23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		5ubm COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens)		6 / 8ASP A 626
SER A 627
SER A 632
VAL A 653
GLY A 656
GLY A 663
None
0.41A29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens)		4 / 8SER B  86
SER B  89
GLY B 181
GLY B  82
GDP  B 801 (-4.1A)
MG  B 804 ( 2.1A)
BEF  B 802 (-3.3A)
None
0.73A17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		6au6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(S) SUBUNIT
ALPHA ISOFORMS SHORT
(Homo
sapiens)		4 / 8SER A  51
SER A  54
GLY A 226
GLY A  47
GDP  A 401 (-3.4A)
MG  A 402 ( 2.1A)
None
None
0.64A15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		6b74 COAGULATION FACTOR
XII
(Homo
sapiens)		5 / 8ASP B 189
GLN B 192
SER B 195
GLY B 216
GLY B 226
BEN  B 301 (-2.7A)
SO4  B 304 (-4.4A)
SO4  B 304 ( 2.5A)
BEN  B 301 (-3.3A)
BEN  B 301 (-3.1A)
0.51A17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		1now BETA-HEXOSAMINIDASE
BETA CHAIN
(Homo
sapiens)		4 / 6GLU A 357
ASP A 354
ASP A 290
ARG A 211
None
IFG  A 557 (-3.6A)
None
IFG  A 557 (-2.8A)
1.15A21.20
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		1s1d APYRASE
(Homo
sapiens)		4 / 6ASP A  42
ASP A 112
GLU A 145
ARG A  93
GP2  A4001 (-3.7A)
GP2  A4001 (-4.2A)
GP2  A4001 ( 2.7A)
None
1.41A20.94
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		1s1d APYRASE
(Homo
sapiens)		4 / 6GLU A 295
ASP A  42
ASP A 112
GLU A 145
None
GP2  A4001 (-3.7A)
GP2  A4001 (-4.2A)
GP2  A4001 ( 2.7A)
1.31A20.94
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens)		4 / 6GLU A 457
ASP A 387
GLU A 424
ARG A 210
None
ZN  A1751 ( 2.6A)
ZN  A1751 (-3.6A)
None
1.09A18.99
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		2gk1 BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN B
(Homo
sapiens)		4 / 6GLU N 357
ASP N 354
ASP M 290
ARG M 211
None
0.89A19.50
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		4 / 6ASP A  64
ASP A  68
GLU A 210
ASN A 192
GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
MG  A 401 ( 3.9A)
None
1.18A21.69
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		2vgi PYRUVATE KINASE
ISOZYMES R/L
(Homo
sapiens)		4 / 6ASP A 339
GLU A 161
ASN A 118
ARG A 116
 MN  A1577 ( 2.6A)
K  A1576 ( 4.8A)
K  A1576 (-4.0A)
PGA  A1575 (-3.7A)
1.16A21.55
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		2xwb COMPLEMENT FACTOR B
(Homo
sapiens)		4 / 6GLU F 595
GLU F 190
ASN F 423
ARG F 683
None
1.36A20.84
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens)		4 / 6GLU A 447
ASP A 377
GLU A 414
ARG A 200
None
ZN  A1751 (-2.5A)
BIX  A   1 ( 2.7A)
BIX  A   1 (-2.7A)
0.96A21.52
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1
(Homo
sapiens)		4 / 6ASP A 333
GLU A 340
ASN A 468
ARG A 471
None
1.06A21.49
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens)		4 / 6GLU A 155
GLU A1105
ASN A 351
ARG A 356
MAL  A2201 (-3.7A)
None
None
None
1.32A21.96
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		4rws C-X-C CHEMOKINE
RECEPTOR TYPE
4/ENDOLYSIN CHIMERIC
PROTEIN
VIRAL MACROPHAGE
INFLAMMATORY PROTEIN
2
(Escherichia
virus
T4;
Homo
sapiens;
Human
gammaherpesvirus
8)		4 / 6GLU A  31
ASP C   9
GLU A 179
ASN A 101
None
1.35A21.36
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		4ye4 HEAVY CHAIN HUMAN
ANTIBODY HJ16
HT593.1 GP120
(Homo
sapiens;
Human
immunodeficiency
virus)		4 / 6GLU H  54
ASP H  98
GLU H  35
ASN G 460
None
1.15A18.34
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		5c2k TRANSFORMING PROTEIN
RHOA,RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens)		4 / 6GLU A  93
ASP A  13
ASP A 249
GLU A  64
None
1.14A20.74
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		5erd DESMOGLEIN-2
(Homo
sapiens)		4 / 6GLU A 107
ASP A 138
ASP A 102
GLU A  11
None
CA  A 616 ( 3.3A)
CA  A 616 (-3.4A)
CA  A 617 ( 2.5A)
1.38A21.22
10.82