POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		1gg3 ERYTHROID MEMBRANE
PROTEIN 4.1R
(Homo
sapiens)		4 / 8ASP A  25
ARG A  29
GLU A  32
ASP A  40
None
1.12A22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		2b5i INTERLEUKIN-2
RECEPTOR BETA CHAIN
CYTOKINE RECEPTOR
COMMON GAMMA CHAIN
(Homo
sapiens;
Homo
sapiens)		4 / 8HIS C 141
HIS C 184
GLU C 149
GLU B 140
None
1.19A20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		2kjd SODIUM/HYDROGEN
EXCHANGE REGULATORY
COFACTOR NHE-RF1
(Homo
sapiens)		4 / 8ASP A  29
HIS A  27
ASP A  94
GLU A  95
None
1.21A21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		2qag SEPTIN-2
(Homo
sapiens)		4 / 8HIS A 212
GLU A 289
ASP A 293
GLU A 297
None
1.16A20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		3h3b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens)		4 / 8HIS A 152
ARG A  78
GLU A 125
GLU A  57
None
0.94A22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		3nmz RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Homo
sapiens)		4 / 8HIS D 205
HIS D 174
GLU D 212
ASP D 209
None
0.89A16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		4hq6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens)		4 / 8ASP A 750
HIS A 647
GLU A 533
ASP A 520
None
1.17A20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2
(Homo
sapiens)		4 / 8ASP A 343
HIS A 282
ARG A 303
ASP A 284
None
1.09A23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		4jgh CULLIN-5
(Homo
sapiens)		4 / 8ASP D  20
ARG D  23
ASP D  68
GLU D  67
None
1.05A21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE
(Homo
sapiens)		4 / 8ASP A  32
ARG A 182
HIS A 181
ASP A 235
FGP  A  70 (-3.0A)
None
FGP  A  70 ( 4.5A)
None
1.12A20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		4nzr PGT135 HEAVY CHAIN
PROTEIN M TD
(Homo
sapiens;
Mycoplasma
genitalium)		5 / 8ASP M 408
ARG M 457
GLU M 453
ASP H  31
GLU H  31
None
1.41A18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		4uf4 CARBOXYPEPTIDASE A1
(Homo
sapiens)		4 / 8HIS A  23
ARG A 181
ASP A  51
GLU A 273
None
1.13A20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		4uhi STEROL 14-ALPHA
DEMETHYLASE
(Homo
sapiens)		4 / 8ASP A 124
ARG A 385
ASP A 129
GLU A 128
None
1.17A19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		5aga DNA POLYMERASE THETA
(Homo
sapiens)		4 / 8HIS A 365
ARG A 438
HIS A 338
GLU A 383
FLC  A1893 ( 4.5A)
FLC  A1893 ( 4.9A)
None
None
1.18A15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		5c5b DCC-INTERACTING
PROTEIN 13-ALPHA
DCC-INTERACTING
PROTEIN 13-BETA
(Homo
sapiens;
Homo
sapiens)		4 / 8ASP A  49
HIS B 100
ARG A  46
HIS A  45
None
1.13A21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		5cvo WD REPEAT-CONTAINING
PROTEIN 48
UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 46
(Homo
sapiens;
Homo
sapiens)		4 / 8ASP A  76
HIS A 116
ASP A 118
GLU B 237
None
1.15A18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		5edu MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HISTONE DEACETYLASE
6 CHIMERA
(Escherichia
coli;
Homo
sapiens)		4 / 8ASP B 662
HIS B 827
ARG B 693
GLU B 685
None
1.22A17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		5hzk INTERSECTIN-1,NPH1-1
,INTERSECTIN-1
(Avena
sativa;
Homo
sapiens)		4 / 8ASP B1545
HIS B1543
GLU B1541
GLU B1537
None
1.23A21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		5k1c UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 12
WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens;
Homo
sapiens)		4 / 8ASP B  76
HIS B 116
ASP B 118
GLU A 241
None
1.23A18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2
(Homo
sapiens)		4 / 8HIS A 172
HIS A 144
ASP A 168
GLU A 216
None
1.24A21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2
(Homo
sapiens)		4 / 8ASP A 587
HIS A 858
GLU A 836
GLU A 768
None
1.21A19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		5w21 FIBROBLAST GROWTH
FACTOR 23
(Homo
sapiens)		4 / 8ASP B 109
ARG B 114
GLU B  78
ASP B  79
None
1.18Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		5ze3 LYSYL OXIDASE
HOMOLOG 2
(Homo
sapiens)		4 / 8ASP A 692
HIS A 623
HIS A 691
GLU A 659
None
1.24Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		2mnz LYSINE-SPECIFIC
DEMETHYLASE 5B
(Homo
sapiens)		4 / 8ASP A 320
ARG A 323
HIS A 335
ASP A 345
None
None
ZN  A 401 (-3.1A)
None
1.23A14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		4 / 8ARG A 133
GLU A 210
ASP A  68
GLU A  67
None
MG  A 401 ( 3.9A)
MG  A 400 (-2.6A)
None
0.98A22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		2qag SEPTIN-2
(Homo
sapiens)		4 / 8HIS A 212
GLU A 289
ASP A 293
GLU A 297
None
1.10A20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		2qna IMPORTIN SUBUNIT
BETA-1
SNURPORTIN-1
(Homo
sapiens;
Homo
sapiens)		4 / 8ASP A 579
ARG B  43
ASP A 627
GLU A 626
None
1.27A17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		3h3b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens)		4 / 8HIS A 152
ARG A  78
GLU A 125
GLU A  57
None
1.11A22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		3nxp PRETHROMBIN-1
(Homo
sapiens)		4 / 8ASP A 578
HIS A 491
ASP A 500
GLU A 497
None
None
None
TRS  A 702 ( 3.9A)
1.15A20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		3u1k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL
(Homo
sapiens)		4 / 8HIS A 381
ARG A 471
HIS A 426
ASP A 400
None
1.02A17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		4btm TAU-TUBULIN KINASE 1
(Homo
sapiens)		4 / 8ASP A 178
HIS A 235
HIS A 176
GLU A 255
None
1.09A20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		4jgh CULLIN-5
(Homo
sapiens)		4 / 8ASP D  20
ARG D  23
ASP D  68
GLU D  67
None
1.14A21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		4qei GLYCINE--TRNA LIGASE
(Homo
sapiens)		4 / 8ASP A  66
HIS A 537
ARG A  67
GLU A 536
None
None
C  C  70 ( 4.5A)
None
1.24A18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct)		4 / 8HIS A1344
GLU A1439
ASP A1436
GLU A2082
None
1.18A6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens)		4 / 8ASP A 217
HIS A 147
ASP A 173
GLU A  79
None
1.21A21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		5aga DNA POLYMERASE THETA
(Homo
sapiens)		4 / 8HIS A 365
ARG A 438
HIS A 338
GLU A 383
FLC  A1893 ( 4.5A)
FLC  A1893 ( 4.9A)
None
None
1.24A15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		5all SOLUBLE EPOXIDE
HYDROLASE
(Homo
sapiens)		4 / 8ASP A 129
ARG A 130
GLU A 132
ASP A  93
None
1.14A20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		5c5b DCC-INTERACTING
PROTEIN 13-ALPHA
DCC-INTERACTING
PROTEIN 13-BETA
(Homo
sapiens;
Homo
sapiens)		4 / 8ASP A  49
HIS B 100
ARG A  46
HIS A  45
None
1.22A21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		5edu MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HISTONE DEACETYLASE
6 CHIMERA
(Escherichia
coli;
Homo
sapiens)		4 / 8ASP B 662
HIS B 827
ARG B 693
GLU B 685
None
1.23A17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens)		4 / 8HIS A4100
HIS A4054
ASP A2030
GLU A4206
None
1.26A4.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
9, MITOCHONDRIAL
(Homo
sapiens)		4 / 8TRP J 313
ASP J 133
ARG J 132
GLU J 311
None
None
NDP  J 401 (-3.2A)
None
1.23A22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		5ze3 LYSYL OXIDASE
HOMOLOG 2
(Homo
sapiens)		4 / 8ASP A 692
HIS A 623
HIS A 691
GLU A 659
None
1.25Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		1e33 ARYLSULFATASE A
(Homo
sapiens)		4 / 8HIS P 125
HIS P 227
ASP P 281
GLU P 312
DDZ  P  69 ( 3.9A)
None
MG  P 603 (-2.2A)
None
1.18A21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		2qag SEPTIN-2
(Homo
sapiens)		4 / 8HIS A 212
GLU A 289
ASP A 293
GLU A 297
None
1.21A20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		2wz9 GLUTAREDOXIN-3
(Homo
sapiens)		4 / 8ASP A  98
HIS A 104
HIS A 115
GLU A 107
None
1.20A19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		3bxw CHITINASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		4 / 8ASP B 305
HIS B  42
ARG B 307
HIS B 306
None
1.23A23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		3naf CALCIUM-ACTIVATED
POTASSIUM CHANNEL
SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1
(Homo
sapiens)		4 / 8ASP A 812
HIS A 350
GLU A 354
GLU A 386
None
1.31A15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		3nxp PRETHROMBIN-1
(Homo
sapiens)		4 / 8ASP A 578
HIS A 491
ASP A 500
GLU A 497
None
None
None
TRS  A 702 ( 3.9A)
0.89A20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		3su8 PLEXIN-B1
(Homo
sapiens)		4 / 8ASP X2055
HIS X1974
ARG X2051
GLU X2050
None
1.32A17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		3thz DNA MISMATCH REPAIR
PROTEIN MSH2
(Homo
sapiens)		4 / 8ASP A  49
ARG A  35
GLU A 101
GLU A  28
None
1.22A15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens)		4 / 8ASP A 217
HIS A 147
ASP A 173
GLU A  79
None
1.00A21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		5jpn COMPLEMENT C4-A
COMPLEMENT C4-A
(Homo
sapiens;
Homo
sapiens)		4 / 8ASP B1304
ARG B1300
GLU C1563
GLU B 943
None
1.02A15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		5lb3 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens)		4 / 8ARG B 148
HIS B 149
GLU B 119
GLU B 117
None
1.27A21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		5lgg ANAPHASE-PROMOTING
COMPLEX SUBUNIT
1,ANAPHASE-PROMOTING
COMPLEX SUBUNIT
1,ANAPHASE-PROMOTING
COMPLEX SUBUNIT
1,ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens)		4 / 8ASP A  88
ARG A 594
HIS A 592
ASP A  16
None
1.23A19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		5ool 39S RIBOSOMAL
PROTEIN L38,
MITOCHONDRIAL
(Homo
sapiens)		4 / 8ASP 6 302
ARG 6 299
GLU 6 231
GLU 6 227
None
1.26A22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		2nz2 ARGININOSUCCINATE
SYNTHASE
(Homo
sapiens)		4 / 8TRP A 145
ASP A 124
ARG A 272
GLU A 196
None
ASP  A 501 ( 3.6A)
ASP  A 501 ( 4.6A)
None
1.21A21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		3wu1 PROTEIN C-ETS-1
(Homo
sapiens)		4 / 8ARG B 413
HIS B 403
GLU B 362
ASP B 359
None
0.92A16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		4btm TAU-TUBULIN KINASE 1
(Homo
sapiens)		4 / 8ASP A 178
HIS A 235
HIS A 176
GLU A 255
None
1.06A20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE
(Homo
sapiens)		4 / 8ASP A  32
ARG A 182
HIS A 181
ASP A 235
FGP  A  70 (-3.0A)
None
FGP  A  70 ( 4.5A)
None
1.23A20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1
(Homo
sapiens)		4 / 8HIS A 102
ARG A 174
ASP A 171
GLU A 170
None
1.08A21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens)		4 / 8ASP A 262
HIS A 306
ARG A 265
ASP A 311
None
0.98A20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens)		4 / 8ASP B 262
HIS B 306
ARG B 265
ASP B 311
None
0.97A22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct)		4 / 8ASP A3239
ARG A3241
GLU A3266
ASP A3262
None
1.06A6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct)		4 / 8HIS A1344
GLU A1439
ASP A1436
GLU A2082
None
1.11A6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens)		4 / 8HIS A4100
HIS A4054
ASP A2030
GLU A4206
None
1.19A4.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		5vfr PROTEASOME SUBUNIT
ALPHA TYPE-2
(Homo
sapiens)		4 / 8HIS H  63
ARG H  91
HIS H  88
GLU H  66
None
1.09Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		5ze3 LYSYL OXIDASE
HOMOLOG 2
(Homo
sapiens)		4 / 8ASP A 692
HIS A 623
HIS A 691
GLU A 659
None
1.09Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		1e33 ARYLSULFATASE A
(Homo
sapiens)		4 / 7THR P 408
ARG P 299
HIS P 397
ASP P 411
None
1.32A21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		1p49 STERYL-SULFATASE
(Homo
sapiens)		4 / 7HIS A 288
THR A 261
HIS A 346
ASP A  35
None
None
None
CA  A 605 (-3.1A)
1.27A19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens)		4 / 7HIS A 404
THR A 403
ARG A 275
ASP A 293
None
1.11A13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		3nmz RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Homo
sapiens)		4 / 7HIS D 205
HIS D 174
GLU D 212
ASP D 209
None
1.02A16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		4fys AMINOPEPTIDASE N
(Homo
sapiens)		4 / 7TRP A 303
THR A 244
ARG A 305
HIS A 313
None
None
SO4  A1014 (-3.0A)
None
1.25A14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		4k92 CLIP-ASSOCIATING
PROTEIN 1
(Homo
sapiens)		4 / 7THR A 413
ARG A 341
HIS A 336
ASP A 379
None
1.38A20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		4nge PRESEQUENCE
PROTEASE,
MITOCHONDRIAL
(Homo
sapiens)		4 / 7ARG D 385
HIS D 229
GLU D 386
ASP D 336
None
1.31A12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		4pj6 LEUCYL-CYSTINYL
AMINOPEPTIDASE
(Homo
sapiens)		4 / 7TRP A 808
THR A 862
ARG A 817
ASP A 858
None
1.16A15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		5gpy GENERAL
TRANSCRIPTION FACTOR
IIE SUBUNIT 1
(Homo
sapiens)		4 / 7THR A 175
ARG A 113
HIS A 109
ASP A 117
None
1.03A21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		5gu6 ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 44
(Homo
sapiens)		4 / 7ARG A 329
HIS A 328
GLU A 330
ASP A 336
None
1.37A20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		5uke INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 3
(Homo
sapiens)		4 / 7HIS A 100
ARG A  13
HIS A  19
GLU A  32
None
1.26Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		5vgr ATLASTIN-3
(Homo
sapiens)		4 / 7HIS A 397
THR A 401
HIS A 387
ASP A 396
None
1.33A20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		6f1y CYTOPLASMIC DYNEIN 1
LIGHT INTERMEDIATE
CHAIN 2
(Homo
sapiens)		4 / 7THR j 232
HIS j 115
GLU j  62
ASP j  63
None
1.26Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		2faz UBIQUITIN-LIKE
CONTAINING PHD AND
RING FINGER DOMAINS
PROTEIN 1
(Homo
sapiens)		4 / 7ARG A  29
GLU A  26
ASP A  54
GLU A  53
None
1.42A15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		2nnj CYTOCHROME P450 2C8
(Homo
sapiens)		4 / 7HIS A 329
ARG A 333
HIS A 334
ASP A 328
None
None
SO4  A 503 (-4.0A)
None
1.23A18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		2qag SEPTIN-2
(Homo
sapiens)		4 / 7HIS A 212
GLU A 289
ASP A 293
GLU A 297
None
1.08A20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens)		4 / 7HIS A 687
ARG A 180
ASP A 704
GLU A 706
None
1.35A16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens)		4 / 7TRP A 715
HIS A 608
GLU A 706
ASP A 704
None
1.28A16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		3h3b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens)		4 / 7HIS A 152
ARG A  78
GLU A 125
GLU A  57
None
0.83A22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		3nmz RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Homo
sapiens)		4 / 7HIS D 205
HIS D 174
GLU D 212
ASP D 209
None
0.92A16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		3qnw CASPASE-6
(Homo
sapiens)		4 / 7ARG B 259
HIS B 219
ASP B 231
GLU B 234
None
1.38A15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		4cnm TROPHOBLAST
GLYCOPROTEIN
(Homo
sapiens)		4 / 7HIS A 151
GLU A 216
ASP A 240
GLU A 266
PEG  A1351 ( 4.2A)
CIT  A1356 (-3.8A)
None
None
1.12A24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		4mqj HEMOGLOBIN SUBUNIT
GAMMA-2
(Homo
sapiens)		4 / 7HIS B  97
ARG B 144
HIS B 146
ASP B  94
None
1.30A23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		4nzr PGT135 HEAVY CHAIN
PROTEIN M TD
(Homo
sapiens;
Mycoplasma
genitalium)		4 / 7ARG M 457
GLU M 453
ASP H  31
GLU H  31
None
1.42A18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens)		4 / 7ARG A 163
HIS A 164
ASP A 192
GLU A 189
None
1.31A19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct)		4 / 7HIS A1344
GLU A1439
ASP A1436
GLU A2082
None
1.20A6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		4zg7 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2
(Homo
sapiens)		4 / 7ARG A 369
HIS A 420
GLU A 363
ASP A 364
None
1.11A15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		5a1i S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2
(Homo
sapiens)		4 / 7HIS A  89
HIS A 158
GLU A  27
GLU A 166
None
1.29A22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1
(Homo
sapiens)		4 / 7HIS A 637
HIS A 472
GLU A 642
ASP A 585
None
1.34A19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		5mv9 UNCONVENTIONAL
MYOSIN-VIIA
(Homo
sapiens)		4 / 7ARG A1967
HIS A1968
GLU A1801
ASP A1797
None
1.31A18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		5o6c E3 UBIQUITIN-PROTEIN
LIGASE MYCBP2
(Homo
sapiens)		4 / 7HIS A4583
ARG A4533
GLU A4534
ASP A4531
None
1.29Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		5ukw GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Homo
sapiens)		4 / 7ARG A 285
HIS A 451
GLU A 457
GLU A 193
None
1.33A20.82