POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		1jd0 CARBONIC ANHYDRASE
XII
(Homo
sapiens)		4 / 6ASN A  62
HIS A  64
GLN A  92
THR A 200
None
None
AZM  A1400 (-3.2A)
AZM  A1400 (-3.3A)
0.69A36.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		1nfi I-KAPPA-B-ALPHA
(Homo
sapiens)		4 / 6ASN E 180
HIS E 184
ASN E 145
ILE E 120
None
1.14A21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		2r7e COAGULATION FACTOR
VIII
(Homo
sapiens)		4 / 6ASN B2019
HIS B2082
ILE B1940
GLN B1874
NAG  B2431 ( 4.8A)
None
None
None
1.20A16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		2r7e COAGULATION FACTOR
VIII
(Homo
sapiens)		4 / 6ASN B2019
HIS B2082
ILE B1940
GLN B1938
NAG  B2431 ( 4.8A)
None
None
NAG  B2431 (-3.4A)
1.19A16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		3lxx GTPASE IMAP FAMILY
MEMBER 4
(Homo
sapiens)		4 / 6HIS A  57
ASN A  48
ILE A  50
THR A  66
None
None
None
MG  A 402 (-2.9A)
1.17A21.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		4 / 6ASN A  62
HIS A  64
GLN A  92
THR A 200
None
None
AZM  A 264 (-4.1A)
AZM  A 264 (-3.5A)
0.44A55.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		3uyq CARBONIC ANHYDRASE 3
(Homo
sapiens)		4 / 6ASN A  62
HIS A  64
GLN A  92
THR A 199
None
0.56A58.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		4gnk 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens)		4 / 6ASN B 305
ILE B 250
GLN B 254
THR B 842
None
1.24A11.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		5 / 6ASN A  62
ASN A  67
ILE A  91
GLN A  92
THR A 200
None
0.13A95.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		4 / 6ASN A  62
HIS A  64
GLN A  92
THR A 200
GOL  A 303 (-3.9A)
None
GOL  A 303 (-3.2A)
GOL  A 303 ( 3.5A)
0.36A36.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens)		4 / 6ASN C 549
HIS C 553
ILE C 728
THR D 309
None
1.04A12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		5npr UDP-N-ACETYLGLUCOSAM
INE--PEPTIDE
N-ACETYLGLUCOSAMINYL
TRANSFERASE 110 KDA
SUBUNIT
(Homo
sapiens)		4 / 6ASN A 638
ASN A 628
ILE A 667
THR A 633
None
1.08A18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens)		4 / 6ASN C 476
HIS C 473
ASN C 449
ILE C 390
None
1.23A14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		5yjh PERIOSTIN
(Homo
sapiens)		4 / 6HIS A 198
ASN A 201
ILE A  68
THR A 205
None
None
None
MG  A 728 (-3.6A)
1.07A18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		6fe1 CARBONIC ANHYDRASE 9
(Homo
sapiens)		4 / 6ASN A  62
HIS A  64
GLN A  92
THR A 200
V14  A 302 (-3.4A)
None
V14  A 302 (-3.8A)
V14  A 302 (-3.5A)
0.40A14.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7U_A_ALEA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		1p1v SUPEROXIDE DISMUTASE
[CU-ZN]
(Homo
sapiens)		4 / 6GLU A  21
LYS A  23
PRO A  28
TRP A  32
None
1.32A98.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7U_A_ALEA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		1p1v SUPEROXIDE DISMUTASE
[CU-ZN]
(Homo
sapiens)		4 / 6GLU A  21
PRO A  28
TRP A  32
GLU A 100
None
0.74A98.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7U_A_ALEA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		2de0 ALPHA-(1,6)-FUCOSYLT
RANSFERASE
(Homo
sapiens)		4 / 6GLU X 183
PRO X 484
LYS X 185
GLU X 181
None
1.26A15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7U_A_ALEA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		4fdd TRANSPORTIN-1
(Homo
sapiens)		4 / 6GLU A 230
LYS A 189
PRO A 188
GLU A 228
None
1.34A11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7U_A_ALEA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		4po6 INTERFERON
ALPHA/BETA RECEPTOR
1
NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens)		4 / 6GLU B 500
PRO A 506
LYS B 501
GLU A 517
None
1.32A11.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7U_A_ALEA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		4xcr SUPEROXIDE DISMUTASE
[CU-ZN]
(Homo
sapiens)		4 / 6GLU A  21
PRO A  28
LYS A  30
GLU A  70
None
0.67A67.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7U_A_ALEA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		4xcr SUPEROXIDE DISMUTASE
[CU-ZN]
(Homo
sapiens)		4 / 6LYS A  23
PRO A  28
LYS A  30
GLU A  70
None
0.74A67.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7U_A_ALEA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		5j0g OXIDOREDUCTASE,SUPER
OXIDE DISMUTASE
[CU-ZN]
(Homo
sapiens)		4 / 6GLU A  39
PRO A  46
LYS A  48
GLU A  88
None
0.68A56.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7U_A_ALEA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		5j0g OXIDOREDUCTASE,SUPER
OXIDE DISMUTASE
[CU-ZN]
(Homo
sapiens)		4 / 6LYS A  41
PRO A  46
LYS A  48
GLU A  88
None
0.56A56.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7U_A_ALEA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens)		4 / 6LYS A   3
PRO A  63
LYS A  61
GLU A  64
None
1.26A18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		2fl5 IMMUNOGLOBULIN IGG1
HEAVY CHAIN
(Homo
sapiens)		5 / 10VAL H 171
VAL H 191
SER H 189
ASN H 209
ASN H 162
None
1.44A20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		2wq9 RETINOL-BINDING
PROTEIN 4
(Homo
sapiens)		5 / 10ASP A 108
VAL A 107
VAL A 116
SER A 134
TYR A 114
GOL  A1180 (-3.5A)
GOL  A1180 (-4.7A)
None
None
None
1.41A17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		3g04 HUMAN THYROID
STIMULATING
AUTOANTIBODY M22
HEAVY CHAIN
(Homo
sapiens)		5 / 10VAL B 163
VAL B 182
SER B 180
ASN B 197
ASN B 155
None
1.49A18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		3mlx HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 3074 FAB
HEAVY CHAIN
(Homo
sapiens)		5 / 10VAL H 163
VAL H 182
SER H 180
ASN H 197
ASN H 155
None
1.46A16.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens)		5 / 10ASP A 110
VAL A 111
SER A 192
PHE A 345
TYR A 373
ETQ  A1200 (-3.5A)
ETQ  A1200 (-3.4A)
ETQ  A1200 (-3.3A)
ETQ  A1200 (-4.4A)
ETQ  A1200 (-4.4A)
0.84A31.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens)		5 / 10ASP A 110
VAL A 111
SER A 196
PHE A 345
TYR A 373
ETQ  A1200 (-3.5A)
ETQ  A1200 (-3.4A)
ETQ  A1200 ( 4.6A)
ETQ  A1200 (-4.4A)
ETQ  A1200 (-4.4A)
0.53A31.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME
(Escherichia
virus
T4;
Homo
sapiens)		6 / 10ASP A 113
VAL A 114
SER A 207
PHE A 289
ASN A 312
TYR A 316
ERC  A1201 (-3.7A)
ERC  A1201 (-3.8A)
ERC  A1201 (-2.7A)
ERC  A1201 (-4.5A)
ERC  A1201 (-3.0A)
None
1.08A58.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME
(Escherichia
virus
T4;
Homo
sapiens)		8 / 10ASP A 113
VAL A 114
VAL A 117
PHE A 193
SER A 203
PHE A 289
ASN A 312
TYR A 316
ERC  A1201 (-3.7A)
ERC  A1201 (-3.8A)
None
ERC  A1201 (-4.4A)
ERC  A1201 (-2.8A)
ERC  A1201 (-4.5A)
ERC  A1201 (-3.0A)
None
0.74A58.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME
(Escherichia
virus
T4;
Homo
sapiens)		9 / 10ASP A 113
VAL A 114
VAL A 117
PHE A 193
SER A 203
SER A 207
PHE A 289
ASN A 293
ASN A 312
ERC  A1201 (-3.7A)
ERC  A1201 (-3.8A)
None
ERC  A1201 (-4.4A)
ERC  A1201 (-2.8A)
ERC  A1201 (-2.7A)
ERC  A1201 (-4.5A)
ERC  A1201 (-3.5A)
ERC  A1201 (-3.0A)
0.80A58.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME
(Escherichia
virus
T4;
Homo
sapiens)		5 / 10VAL A 117
SER A 204
PHE A 289
ASN A 312
TYR A 316
None
ERC  A1201 ( 4.1A)
ERC  A1201 (-4.5A)
ERC  A1201 (-3.0A)
None
1.04A58.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME
(Escherichia
virus
T4;
Homo
sapiens)		6 / 10VAL A 117
SER A 204
SER A 207
PHE A 289
ASN A 293
ASN A 312
None
ERC  A1201 ( 4.1A)
ERC  A1201 (-2.7A)
ERC  A1201 (-4.5A)
ERC  A1201 (-3.5A)
ERC  A1201 (-3.0A)
1.42A58.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		3qhf HUMAN MONOCLONAL
ANTIBODY DEL2D1,
FAB HEAVY CHAIN
(Homo
sapiens)		5 / 10VAL H 171
VAL H 191
SER H 189
ASN H 209
ASN H 162
None
1.45A19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		3uji FAB REGION OF THE
HEAVY CHAIN OF
ANTI-HIV-1 V3
MONOCLONAL ANTIBODY
2558
(Homo
sapiens)		5 / 10VAL H 163
VAL H 182
SER H 180
ASN H 197
ASN H 155
None
1.46A18.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		4gbr BETA-2 ADRENERGIC
RECEPTOR
(Homo
sapiens)		6 / 10ASP A 113
VAL A 114
PHE A 193
SER A 203
SER A 207
PHE A 261
CAU  A 500 (-3.0A)
CAU  A 500 (-3.5A)
CAU  A 500 (-4.5A)
CAU  A 500 (-3.3A)
CAU  A 500 (-4.1A)
CAU  A 500 (-4.2A)
1.05A99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		4gbr BETA-2 ADRENERGIC
RECEPTOR
(Homo
sapiens)		6 / 10ASP A 113
VAL A 114
PHE A 193
SER A 207
PHE A 261
ASN A 265
CAU  A 500 (-3.0A)
CAU  A 500 (-3.5A)
CAU  A 500 (-4.5A)
CAU  A 500 (-4.1A)
CAU  A 500 (-4.2A)
CAU  A 500 (-3.4A)
1.09A99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		4gbr BETA-2 ADRENERGIC
RECEPTOR
(Homo
sapiens)		7 / 10ASP A 113
VAL A 114
VAL A 117
PHE A 193
PHE A 261
ASN A 265
TYR A 288
CAU  A 500 (-3.0A)
CAU  A 500 (-3.5A)
CAU  A 500 (-4.2A)
CAU  A 500 (-4.5A)
CAU  A 500 (-4.2A)
CAU  A 500 (-3.4A)
CAU  A 500 (-4.6A)
0.82A99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		4gbr BETA-2 ADRENERGIC
RECEPTOR
(Homo
sapiens)		7 / 10ASP A 113
VAL A 114
VAL A 117
PHE A 193
SER A 203
PHE A 261
TYR A 288
CAU  A 500 (-3.0A)
CAU  A 500 (-3.5A)
CAU  A 500 (-4.2A)
CAU  A 500 (-4.5A)
CAU  A 500 (-3.3A)
CAU  A 500 (-4.2A)
CAU  A 500 (-4.6A)
0.86A99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		4gbr BETA-2 ADRENERGIC
RECEPTOR
(Homo
sapiens)		7 / 10ASP A 113
VAL A 114
VAL A 117
PHE A 261
ASN A 265
ASN A 284
TYR A 288
CAU  A 500 (-3.0A)
CAU  A 500 (-3.5A)
CAU  A 500 (-4.2A)
CAU  A 500 (-4.2A)
CAU  A 500 (-3.4A)
CAU  A 500 (-3.3A)
CAU  A 500 (-4.6A)
0.80A99.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens)		5 / 10ASP A 135
VAL A 136
PHE A 340
ASN A 344
TYR A 370
ERM  A2001 (-3.2A)
ERM  A2001 (-3.8A)
ERM  A2001 (-4.3A)
ERM  A2001 (-4.3A)
ERM  A2001 ( 4.8A)
0.57A27.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR
(Escherichia
virus
T4;
Homo
sapiens)		10 / 10ASP A1113
VAL A1114
VAL A1117
PHE A1193
SER A1203
SER A1207
PHE A1289
ASN A1293
ASN A1312
TYR A1316
P0G  A1401 (-2.9A)
P0G  A1401 (-3.7A)
P0G  A1401 ( 4.4A)
P0G  A1401 (-3.8A)
P0G  A1401 (-2.9A)
P0G  A1401 (-2.8A)
P0G  A1401 ( 4.7A)
P0G  A1401 (-3.0A)
P0G  A1401 (-2.9A)
None
0.34A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR
(Escherichia
virus
T4;
Homo
sapiens)		7 / 10ASP A1113
VAL A1117
SER A1204
SER A1207
ASN A1293
ASN A1312
TYR A1316
P0G  A1401 (-2.9A)
P0G  A1401 ( 4.4A)
P0G  A1401 ( 3.7A)
P0G  A1401 (-2.8A)
P0G  A1401 (-3.0A)
P0G  A1401 (-2.9A)
None
1.12A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		4ot1 SM5-1 FAB HEAVY
CHAIN
(Homo
sapiens)		5 / 10VAL H 181
VAL H 200
SER H 198
ASN H 215
ASN H 173
None
1.48A18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		4py8 ANTIBODY 3.1 HEAVY
CHAIN
(Homo
sapiens)		5 / 10VAL I 168
VAL I 187
SER I 185
ASN I 202
ASN I 160
None
1.46A17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		4rnr PGT130 HEAVY CHAIN
(Homo
sapiens)		5 / 10VAL A 163
VAL A 182
SER A 180
ASN A 197
ASN A 155
None
1.45A18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		5cck ANTIBODY 3BC315 FAB
HEAVY CHAIN
(Homo
sapiens)		5 / 10VAL H 163
VAL H 182
SER H 180
ASN H 197
ASN H 155
None
1.46A19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		5dur HEAVY CHAIN OF
ANTIBODY 100F4
(Homo
sapiens)		5 / 10VAL H 171
VAL H 190
SER H 188
ASN H 205
ASN H 163
None
1.49A18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		5fuz 645 FAB, HEAVY CHAIN
(Homo
sapiens)		5 / 10VAL H 171
VAL H 190
SER H 188
ASN H 205
ASN H 163
None
1.49A18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		5w6g 6649 ANTIBODY HEAVY
CHAIN
(Homo
sapiens)		5 / 10VAL H 175
VAL H 194
SER H 192
ASN H 209
ASN H 167
None
1.46A9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA
(Escherichia
coli;
Homo
sapiens)		5 / 10ASP A 115
VAL A 116
SER A 196
PHE A 410
TYR A 438
AQD  A1201 (-3.3A)
AQD  A1201 ( 3.9A)
AQD  A1201 (-2.8A)
AQD  A1201 (-4.7A)
None
0.91A27.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA
(Escherichia
coli;
Homo
sapiens)		5 / 10ASP A 115
VAL A 116
SER A 200
PHE A 410
TYR A 438
AQD  A1201 (-3.3A)
AQD  A1201 ( 3.9A)
AQD  A1201 (-3.6A)
AQD  A1201 (-4.7A)
None
0.69A27.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens)		5 / 10ASP A 134
SER A 219
PHE A 327
ASN A 331
TYR A 358
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.6A)
None
None
0.87A13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens)		5 / 10ASP A 114
VAL A 115
SER A 197
PHE A 389
TYR A 416
8NU  A2001 ( 3.0A)
8NU  A2001 ( 3.5A)
8NU  A2001 ( 3.6A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.9A)
0.77A10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		6db6 HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 311-11D FAB
HEAVY CHAIN
(Homo
sapiens)		5 / 10VAL H 163
VAL H 182
SER H 180
ASN H 197
ASN H 155
None
1.46A8.11