POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		2wl1 PYRIN
(Homo
sapiens)		5 / 10VAL A 659
GLY A 660
THR A 735
ASN A 733
VAL A 718
None
1.25A20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		2wpm COAGULATION FACTOR
IXA HEAVY CHAIN
(Homo
sapiens)		5 / 10GLY S  43
PHE S  41
GLY S 193
THR S  54
VAL S  32
None
1.32A21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)		5 / 10GLY D 174
PHE D 135
VAL D 125
GLY D 124
VAL D 173
None
1.24A20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		3thc BETA-GALACTOSIDASE
(Homo
sapiens)		5 / 10GLY A 494
VAL A 439
GLY A 438
THR A 405
VAL A 477
None
1.10A17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		4cg4 PYRIN
(Homo
sapiens)		5 / 10VAL A 659
GLY A 660
THR A 735
ASN A 733
VAL A 718
None
1.28A20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		4z2a FURIN
(Homo
sapiens)		5 / 10GLY A 212
VAL A 213
GLY A 214
THR A 354
HIS A 364
 CA  A 601 (-4.4A)
None
None
None
PO4  A 605 (-3.7A)
1.31A20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		5b4w PLEXIN-B1
(Homo
sapiens)		5 / 10GLY A 169
PHE A 230
VAL A 153
GLY A 154
THR A 185
None
1.11A17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		5k5f HELICASE-LIKE
TRANSCRIPTION FACTOR
(Homo
sapiens)		5 / 10VAL A  83
GLY A 132
MET A 148
ASN A 139
HIS A  66
None
1.16A18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		5l3q SIGNAL RECOGNITION
PARTICLE RECEPTOR
SUBUNIT ALPHA
(Homo
sapiens)		5 / 10GLY B 430
GLU B 552
VAL B 429
GLY B 428
THR B 433
GNP  B 705 (-3.1A)
None
GNP  B 705 (-4.1A)
GNP  B 705 (-3.4A)
GNP  B 705 (-3.6A)
1.24A20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		5uan RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens)		5 / 10GLY B 145
PHE B 105
VAL B  95
GLY B  94
VAL B 144
None
1.22A21.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		5ugf PURINE NUCLEOSIDE
PHOSPHORYLASE
(Homo
sapiens)		10 / 10GLY A 118
PHE A 200
GLU A 201
VAL A 217
GLY A 218
MET A 219
THR A 242
ASN A 243
VAL A 245
HIS A 257
IM5  A 308 (-3.7A)
IM5  A 308 (-4.6A)
IM5  A 308 (-2.9A)
IM5  A 308 (-4.4A)
IM5  A 308 (-3.4A)
IM5  A 308 (-3.5A)
IM5  A 308 (-4.3A)
IM5  A 308 (-3.1A)
IM5  A 308 ( 4.5A)
IM5  A 308 (-3.6A)
0.62A99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		5ugf PURINE NUCLEOSIDE
PHOSPHORYLASE
(Homo
sapiens)		5 / 10GLY A 218
PHE A 200
GLU A 201
GLY A 197
HIS A 257
IM5  A 308 (-3.4A)
IM5  A 308 (-4.6A)
IM5  A 308 (-2.9A)
None
IM5  A 308 (-3.6A)
1.15A99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		5ugf PURINE NUCLEOSIDE
PHOSPHORYLASE
(Homo
sapiens)		5 / 10GLY A 218
PHE A 200
GLY A 197
VAL A 217
HIS A 257
IM5  A 308 (-3.4A)
IM5  A 308 (-4.6A)
None
IM5  A 308 (-4.4A)
IM5  A 308 (-3.6A)
1.22A99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		5ugf PURINE NUCLEOSIDE
PHOSPHORYLASE
(Homo
sapiens)		5 / 10PHE A 200
GLU A 201
VAL A 245
GLY A 118
HIS A 257
IM5  A 308 (-4.6A)
IM5  A 308 (-2.9A)
IM5  A 308 ( 4.5A)
IM5  A 308 (-3.7A)
IM5  A 308 (-3.6A)
1.22A99.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KI5_A_AC2A1_1
(PROTEIN (THYMIDINE
KINASE))		1uwy CARBOXYPEPTIDASE M
(Homo
sapiens)		5 / 12GLU A  58
ILE A  56
GLN A 301
TYR A 331
ARG A 101
None
1.06A21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KI5_A_AC2A1_1
(PROTEIN (THYMIDINE
KINASE))		2ocp DEOXYGUANOSINE
KINASE
(Homo
sapiens)		5 / 12TRP A  75
TYR A 100
GLN A 111
ARG A 208
GLU A 211
None
DTP  A 301 (-4.5A)
DTP  A 301 (-2.9A)
DTP  A 301 (-3.4A)
DTP  A 301 (-3.5A)
1.31A23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KI5_A_AC2A1_1
(PROTEIN (THYMIDINE
KINASE))		3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens)		5 / 12GLU A 540
ILE A 474
ILE A 484
MET A 469
TYR A 534
None
1.38A21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KI5_A_AC2A1_1
(PROTEIN (THYMIDINE
KINASE))		4p7h MYOSIN-7,GREEN
FLUORESCENT PROTEIN
(Aequorea
victoria;
Homo
sapiens)		5 / 12HIS A 691
GLU A 677
ILE A 674
ILE A 673
GLU A 179
None
1.42A16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KI5_B_AC2B2_1
(PROTEIN (THYMIDINE
KINASE))		3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens)		5 / 12GLU A 540
ILE A 474
ILE A 484
MET A 469
TYR A 534
None
1.35A21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KI5_B_AC2B2_1
(PROTEIN (THYMIDINE
KINASE))		5aga DNA POLYMERASE THETA
(Homo
sapiens)		5 / 12GLU A 491
ILE A 458
ILE A 495
ARG A 311
ARG A 456
None
1.33A19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_A_AC2A301_1
(DEOXYCYTIDINE KINASE)		1w2d INOSITOL-TRISPHOSPHA
TE 3-KINASE A
(Homo
sapiens)		5 / 9ILE A 380
GLU A 385
ARG A 432
ASP A 449
LEU A 400
None
1.31A22.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MJR_A_AC2A301_1
(DEOXYCYTIDINE KINASE)		2a30 DEOXYCYTIDINE KINASE
(Homo
sapiens)		9 / 9ILE A  30
GLU A  53
GLN A  97
ARG A 104
ARG A 128
ASP A 133
PHE A 137
TYR A 204
LEU A 208
DCZ  A 302 ( 4.3A)
DCZ  A 302 (-3.0A)
DCZ  A 302 (-3.2A)
None
DCZ  A 302 (-4.1A)
DCZ  A 302 (-3.2A)
DCZ  A 302 (-3.8A)
None
None
0.81A92.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_A_AC2A301_1
(DEOXYCYTIDINE KINASE)		2a74 COMPLEMENT COMPONENT
C3C
(Homo
sapiens)		5 / 9ILE B 866
GLN B 805
ASP B 901
PHE B 807
LEU B 838
None
1.28A22.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MJR_A_AC2A301_1
(DEOXYCYTIDINE KINASE)		2ocp DEOXYGUANOSINE
KINASE
(Homo
sapiens)		6 / 9ILE A  47
GLN A 111
ASP A 147
PHE A 151
TYR A 218
LEU A 222
DTP  A 301 (-3.8A)
DTP  A 301 (-2.9A)
DTP  A 301 (-4.1A)
DTP  A 301 (-3.3A)
None
None
0.96A44.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MJR_A_AC2A301_1
(DEOXYCYTIDINE KINASE)		2ocp DEOXYGUANOSINE
KINASE
(Homo
sapiens)		7 / 9ILE A  47
GLU A  70
GLN A 111
ARG A 142
PHE A 151
TYR A 218
LEU A 222
DTP  A 301 (-3.8A)
None
DTP  A 301 (-2.9A)
DTP  A 301 (-3.2A)
DTP  A 301 (-3.3A)
None
None
0.72A44.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_A_AC2A301_1
(DEOXYCYTIDINE KINASE)		2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens)		5 / 9ILE B 866
GLN B 805
ASP B 901
PHE B 807
LEU B 838
None
1.22A14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_A_AC2A301_1
(DEOXYCYTIDINE KINASE)		3b6v KINESIN-LIKE PROTEIN
KIF3C
(Homo
sapiens)		5 / 9ILE A  32
GLU A  24
GLN A  98
ARG A  18
LEU A  44
None
1.16A22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_A_AC2A301_1
(DEOXYCYTIDINE KINASE)		5ons MALIGNANT
T-CELL-AMPLIFIED
SEQUENCE 1
(Homo
sapiens)		5 / 9GLU A  75
GLN A  32
ARG A  72
PHE A  78
LEU A  62
None
1.43A14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_A_AC2A301_1
(DEOXYCYTIDINE KINASE)		5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens)		5 / 9ILE w  66
GLN w 132
ARG w 161
ASP w 166
TYR w 233
None
1.02A22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_A_AC2A301_1
(DEOXYCYTIDINE KINASE)		5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens)		5 / 9ILE w  66
GLU w 160
ARG w 161
ASP w 166
TYR w 233
None
1.35A22.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MJR_B_AC2B401_1
(DEOXYCYTIDINE KINASE)		2a30 DEOXYCYTIDINE KINASE
(Homo
sapiens)		8 / 9ILE A  30
GLU A  53
PHE A  96
GLN A  97
ARG A 104
ARG A 128
ASP A 133
PHE A 137
DCZ  A 302 ( 4.3A)
DCZ  A 302 (-3.0A)
DCZ  A 302 (-4.6A)
DCZ  A 302 (-3.2A)
None
DCZ  A 302 (-4.1A)
DCZ  A 302 (-3.2A)
DCZ  A 302 (-3.8A)
0.71A92.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MJR_B_AC2B401_1
(DEOXYCYTIDINE KINASE)		2ocp DEOXYGUANOSINE
KINASE
(Homo
sapiens)		5 / 9ILE A  47
PHE A 110
ARG A 142
ASP A 147
PHE A 151
DTP  A 301 (-3.8A)
DTP  A 301 (-4.2A)
DTP  A 301 (-3.2A)
DTP  A 301 (-4.1A)
DTP  A 301 (-3.3A)
0.92A44.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MJR_B_AC2B401_1
(DEOXYCYTIDINE KINASE)		2ocp DEOXYGUANOSINE
KINASE
(Homo
sapiens)		5 / 9ILE A  47
PHE A 110
GLN A 111
ARG A 142
PHE A 151
DTP  A 301 (-3.8A)
DTP  A 301 (-4.2A)
DTP  A 301 (-2.9A)
DTP  A 301 (-3.2A)
DTP  A 301 (-3.3A)
0.63A44.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		2a30 DEOXYCYTIDINE KINASE
(Homo
sapiens)		6 / 8GLU A  53
GLN A  97
ARG A 104
ARG A 128
ASP A 133
PHE A 137
DCZ  A 302 (-3.0A)
DCZ  A 302 (-3.2A)
None
DCZ  A 302 (-4.1A)
DCZ  A 302 (-3.2A)
DCZ  A 302 (-3.8A)
0.78A92.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		2a30 DEOXYCYTIDINE KINASE
(Homo
sapiens)		6 / 8GLU A  53
TYR A  86
GLN A  97
ARG A 104
ARG A 128
ASP A 133
DCZ  A 302 (-3.0A)
DCZ  A 302 (-4.6A)
DCZ  A 302 (-3.2A)
None
DCZ  A 302 (-4.1A)
DCZ  A 302 (-3.2A)
0.86A92.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		2a30 DEOXYCYTIDINE KINASE
(Homo
sapiens)		5 / 8PHE A  96
GLN A  97
ARG A 128
ASP A 133
PHE A 137
DCZ  A 302 (-4.6A)
DCZ  A 302 (-3.2A)
DCZ  A 302 (-4.1A)
DCZ  A 302 (-3.2A)
DCZ  A 302 (-3.8A)
0.89A92.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		2a30 DEOXYCYTIDINE KINASE
(Homo
sapiens)		5 / 8TYR A  86
PHE A  96
GLN A  97
ARG A 128
ASP A 133
DCZ  A 302 (-4.6A)
DCZ  A 302 (-4.6A)
DCZ  A 302 (-3.2A)
DCZ  A 302 (-4.1A)
DCZ  A 302 (-3.2A)
0.92A92.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		2ocp DEOXYGUANOSINE
KINASE
(Homo
sapiens)		5 / 8GLU A  70
TYR A 100
PHE A 110
GLN A 111
ASP A 147
None
DTP  A 301 (-4.5A)
DTP  A 301 (-4.2A)
DTP  A 301 (-2.9A)
DTP  A 301 (-4.1A)
1.41A44.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		2wex APOLIPOPROTEIN M
(Homo
sapiens)		4 / 8GLU A 136
PHE A  71
ARG A 143
PHE A  63
GYM  A1186 (-3.1A)
GYM  A1186 (-3.8A)
None
GYM  A1186 (-4.6A)
1.07A21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		3e0j DNA POLYMERASE
SUBUNIT DELTA-2
(Homo
sapiens)		4 / 8PHE A 395
ARG A  57
ASP A 391
PHE A 393
None
1.07A23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		3mda DNA POLYMERASE
LAMBDA
(Homo
sapiens)		4 / 8GLU A 315
TYR A 279
ARG A 323
ASP A 326
None
1.18A24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		3o6f HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DRB1-4 BETA
CHAIN
(Homo
sapiens)		4 / 8GLU B  43
GLN B  39
ARG B  58
PHE B  60
None
0.95A19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		4d10 COP9 SIGNALOSOME
COMPLEX SUBUNIT 8
(Homo
sapiens)		4 / 8GLU H 107
PHE H  13
ARG H 110
ASP H 111
None
1.08A20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		4ern TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPB
SUBUNIT
(Homo
sapiens)		4 / 8GLU A 570
PHE A 518
ARG A 574
PHE A 703
None
1.17A19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		4mob ACYL-COENZYME A
THIOESTERASE 12
(Homo
sapiens)		4 / 8GLU A  86
ARG A 147
ARG A 143
ASP A  57
None
0.98A20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		4y19 HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DRB1-4 BETA
CHAIN
(Homo
sapiens)		4 / 8GLU B  14
GLN B  10
ARG B  29
PHE B  31
None
0.96A19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		5v89 DCN1-LIKE PROTEIN 4
(Homo
sapiens)		4 / 8GLU A 284
TYR A 244
PHE A 238
GLN A 241
None
1.04A23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens)		4 / 8GLN w 132
ARG w 139
ARG w 161
ASP w 166
None
1.20A22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		2qq2 CYTOSOLIC ACYL
COENZYME A THIOESTER
HYDROLASE
(Homo
sapiens)		5 / 10GLY A 284
ALA A 318
VAL A 298
GLU A 297
VAL A 247
None
1.17A25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		3euf URIDINE
PHOSPHORYLASE 1
(Homo
sapiens)		6 / 10MET A 110
ARG A 138
GLY A 143
GLU A 248
MET A 249
GLU A 250
BAU  A 400 (-3.5A)
PO4  A 401 (-3.0A)
BAU  A 400 (-3.3A)
None
BAU  A 400 (-3.8A)
PO4  A 401 ( 4.2A)
0.38A27.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		3p0f URIDINE
PHOSPHORYLASE 2
(Homo
sapiens)		6 / 10MET A 116
ARG A 144
GLY A 149
GLU A 254
MET A 255
GLU A 256
BAU  A 400 (-3.4A)
None
BAU  A 400 (-3.5A)
None
BAU  A 400 (-3.9A)
None
0.42A26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		5tf2 PROLACTIN REGULATORY
ELEMENT-BINDING
PROTEIN
(Homo
sapiens)		5 / 10GLY A 318
ALA A 341
VAL A 324
SER A 304
VAL A 349
None
1.03A20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		5zal ENDORIBONUCLEASE
DICER
(Homo
sapiens)		5 / 10GLY A 204
ALA A  74
VAL A 173
GLU A  80
SER A 232
None
1.20A15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		2fvv DIPHOSPHOINOSITOL
POLYPHOSPHATE
PHOSPHOHYDROLASE 1
(Homo
sapiens)		5 / 9ARG A 115
SER A  39
ALA A  22
VAL A  48
GLU A  70
IHP  A2360 ( 4.5A)
IHP  A2360 (-3.2A)
None
None
None
1.16A19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		3euf URIDINE
PHOSPHORYLASE 1
(Homo
sapiens)		5 / 9MET A 110
ARG A 138
GLY A 143
MET A 249
GLU A 250
BAU  A 400 (-3.5A)
PO4  A 401 (-3.0A)
BAU  A 400 (-3.3A)
BAU  A 400 (-3.8A)
PO4  A 401 ( 4.2A)
0.40A26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		3mcf DIPHOSPHOINOSITOL
POLYPHOSPHATE
PHOSPHOHYDROLASE
3-ALPHA
(Homo
sapiens)		5 / 9ARG A 115
SER A  38
ALA A  21
VAL A  47
GLU A  69
FLC  A   0 (-3.1A)
FLC  A   0 (-3.2A)
None
None
FLC  A   0 ( 4.7A)
1.20A18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		3p0f URIDINE
PHOSPHORYLASE 2
(Homo
sapiens)		5 / 9MET A 116
ARG A 144
GLY A 149
MET A 255
GLU A 256
BAU  A 400 (-3.4A)
None
BAU  A 400 (-3.5A)
BAU  A 400 (-3.9A)
None
0.40A24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens)		5 / 9ARG A1279
ALA A1297
VAL A1251
GLU A1276
ILE A1206
None
1.39A10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		5fn4 NICASTRIN
(Homo
sapiens)		5 / 9SER A 340
GLY A 332
ALA A 298
GLU A 364
ILE A 555
None
1.26A16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens)		5 / 9ARG A1279
ALA A1297
VAL A1251
GLU A1276
ILE A1206
None
1.39A8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
NEDD8-CONJUGATING
ENZYME UBC12
(Homo
sapiens)		5 / 10GLY B2251
VAL B2285
GLU C 117
ASP B2253
ILE B2257
None
1.19A17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		2ovj RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens)		5 / 10MET A 491
GLY A 501
VAL A 528
GLU A 529
ILE A 504
None
1.17A23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		2z6k REPLICATION PROTEIN
A 32 KDA SUBUNIT
(Homo
sapiens)		5 / 10GLY A  78
VAL A 126
GLU A 154
ASP A  96
ILE A  94
None
1.14A20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		3euf URIDINE
PHOSPHORYLASE 1
(Homo
sapiens)		5 / 10MET A 110
GLY A 143
GLU A 248
MET A 249
GLU A 250
BAU  A 400 (-3.5A)
BAU  A 400 (-3.3A)
None
BAU  A 400 (-3.8A)
PO4  A 401 ( 4.2A)
0.32A26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		3p0f URIDINE
PHOSPHORYLASE 2
(Homo
sapiens)		5 / 10MET A 116
GLY A 149
GLU A 254
MET A 255
GLU A 256
BAU  A 400 (-3.4A)
BAU  A 400 (-3.5A)
None
BAU  A 400 (-3.9A)
None
0.37A24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		4nef AQUAPORIN-2
(Homo
sapiens)		5 / 10SER A 182
GLY A 207
ALA A 127
VAL A 131
ILE A 206
None
1.14A21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		4oj2 AQUAPORIN-2
(Homo
sapiens)		5 / 10SER X 182
GLY X 207
ALA X 127
VAL X 131
ILE X 206
None
1.18A21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		1d7w MYELOPEROXIDASE
(Homo
sapiens)		5 / 11GLY C 376
VAL C 371
GLU C 374
ASP C 378
ILE C 377
None
1.22A19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		2v55 RHO-RELATED
GTP-BINDING PROTEIN
RHOE
(Homo
sapiens)		5 / 11SER B  79
GLY B  30
VAL B  29
SER B  32
ASP B  31
GTP  B1201 ( 4.7A)
None
None
GTP  B1201 (-3.3A)
None
1.01A19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		3euf URIDINE
PHOSPHORYLASE 1
(Homo
sapiens)		5 / 11MET A 110
GLY A 143
GLU A 248
MET A 249
GLU A 250
BAU  A 400 (-3.5A)
BAU  A 400 (-3.3A)
None
BAU  A 400 (-3.8A)
PO4  A 401 ( 4.2A)
0.31A26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		3p0f URIDINE
PHOSPHORYLASE 2
(Homo
sapiens)		5 / 11MET A 116
GLY A 149
GLU A 254
MET A 255
GLU A 256
BAU  A 400 (-3.4A)
BAU  A 400 (-3.5A)
None
BAU  A 400 (-3.9A)
None
0.34A24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		5fn4 NICASTRIN
(Homo
sapiens)		5 / 11SER A 340
GLY A 332
ALA A 298
GLU A 364
ILE A 555
None
1.21A16.36