POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		1pcg ESTROGEN RECEPTOR
(Homo
sapiens)		5 / 12ALA A 350
LEU A 387
ARG A 394
VAL A 418
LEU A 525
EST  A   1 ( 3.7A)
EST  A   1 (-4.0A)
EST  A   1 (-3.7A)
None
EST  A   1 (-3.6A)
0.92A31.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		1pcg ESTROGEN RECEPTOR
(Homo
sapiens)		5 / 12ALA A 350
TRP A 383
ARG A 394
ILE A 424
LEU A 525
EST  A   1 ( 3.7A)
None
EST  A   1 (-3.7A)
EST  A   1 ( 4.5A)
EST  A   1 (-3.6A)
0.95A31.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		1pcg ESTROGEN RECEPTOR
(Homo
sapiens)		5 / 12ALA A 350
TRP A 383
LEU A 387
ARG A 394
LEU A 525
EST  A   1 ( 3.7A)
None
EST  A   1 (-4.0A)
EST  A   1 (-3.7A)
EST  A   1 (-3.6A)
0.86A31.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		1uhl RETINOIC ACID
RECEPTOR RXR-BETA
(Homo
sapiens)		10 / 12ALA A 342
ALA A 343
GLN A 346
TRP A 376
LEU A 380
ARG A 387
LEU A 397
ALA A 398
VAL A 413
LEU A 507
MEI  A1001 (-3.1A)
MEI  A1001 (-3.3A)
None
None
MEI  A1001 (-3.8A)
MEI  A1001 (-3.6A)
MEI  A1001 ( 4.4A)
MEI  A1001 (-3.4A)
MEI  A1001 (-4.1A)
MEI  A1001 (-4.6A)
0.79A88.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		1uhl RETINOIC ACID
RECEPTOR RXR-BETA
(Homo
sapiens)		10 / 12ALA A 342
ALA A 343
TRP A 376
LEU A 380
ARG A 387
LEU A 397
ALA A 398
VAL A 413
ILE A 416
LEU A 507
MEI  A1001 (-3.1A)
MEI  A1001 (-3.3A)
None
MEI  A1001 (-3.8A)
MEI  A1001 (-3.6A)
MEI  A1001 ( 4.4A)
MEI  A1001 (-3.4A)
MEI  A1001 (-4.1A)
None
MEI  A1001 (-4.6A)
0.83A88.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		1uhl RETINOIC ACID
RECEPTOR RXR-BETA
(Homo
sapiens)		7 / 12ALA A 342
LEU A 380
ARG A 387
LEU A 397
VAL A 413
ILE A 416
CYH A 503
MEI  A1001 (-3.1A)
MEI  A1001 (-3.8A)
MEI  A1001 (-3.6A)
MEI  A1001 ( 4.4A)
MEI  A1001 (-4.1A)
None
MEI  A1001 (-4.0A)
0.96A88.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		1xls RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens)		7 / 12ALA A 271
ALA A 272
GLN A 275
ARG A 316
LEU A 326
ALA A 327
ILE A 428
9CR  A 801 (-3.6A)
9CR  A 801 (-3.5A)
9CR  A 801 (-4.7A)
9CR  A 801 (-2.6A)
9CR  A 801 (-4.1A)
9CR  A 801 (-3.3A)
None
1.30A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		1xls RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens)		11 / 12ALA A 271
ALA A 272
GLN A 275
TRP A 305
LEU A 309
ARG A 316
LEU A 326
ALA A 327
VAL A 342
ILE A 345
LEU A 436
9CR  A 801 (-3.6A)
9CR  A 801 (-3.5A)
9CR  A 801 (-4.7A)
None
9CR  A 801 (-4.2A)
9CR  A 801 (-2.6A)
9CR  A 801 (-4.1A)
9CR  A 801 (-3.3A)
9CR  A 801 ( 4.3A)
9CR  A 801 ( 4.5A)
9CR  A 801 (-4.7A)
0.71A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		1xls RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens)		9 / 12ALA A 271
ALA A 272
LEU A 309
ARG A 316
LEU A 326
ALA A 327
VAL A 342
ILE A 345
CYH A 432
9CR  A 801 (-3.6A)
9CR  A 801 (-3.5A)
9CR  A 801 (-4.2A)
9CR  A 801 (-2.6A)
9CR  A 801 (-4.1A)
9CR  A 801 (-3.3A)
9CR  A 801 ( 4.3A)
9CR  A 801 ( 4.5A)
9CR  A 801 ( 3.7A)
0.81A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		1xls RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens)		6 / 12ALA A 271
GLN A 275
ARG A 316
ALA A 327
VAL A 342
ILE A 345
9CR  A 801 (-3.6A)
9CR  A 801 (-4.7A)
9CR  A 801 (-2.6A)
9CR  A 801 (-3.3A)
9CR  A 801 ( 4.3A)
9CR  A 801 ( 4.5A)
1.44A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1
(Homo
sapiens)		5 / 12ALA A 223
LEU A 230
LEU A 199
ILE A 260
CYH A 258
None
0.85A18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		2coc FYVE, RHOGEF AND PH
DOMAIN CONTAINING
PROTEIN 3
(Homo
sapiens)		5 / 12ALA A  88
GLN A  94
LEU A  98
LEU A  93
LEU A  38
None
0.76A19.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		2gl8 RETINOIC ACID
RECEPTOR RXR-GAMMA
(Homo
sapiens)		6 / 12LEU A  88
ARG A  95
LEU A 105
VAL A 121
ILE A 124
CYH A 211
None
1.01A88.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		2gl8 RETINOIC ACID
RECEPTOR RXR-GAMMA
(Homo
sapiens)		6 / 12TRP A  84
LEU A  88
ARG A  95
LEU A 105
VAL A 121
ILE A 124
None
0.86A88.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		2ocf ESTROGEN RECEPTOR
(Homo
sapiens)		5 / 12ALA A 350
LEU A 387
ARG A 394
VAL A 418
LEU A 525
EST  A 596 ( 3.9A)
EST  A 596 ( 4.2A)
EST  A 596 (-4.0A)
CME  A 417 ( 3.2A)
EST  A 596 (-3.6A)
0.99A30.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		2ocf ESTROGEN RECEPTOR
(Homo
sapiens)		5 / 12ALA A 350
TRP A 383
LEU A 387
ARG A 394
LEU A 525
EST  A 596 ( 3.9A)
None
EST  A 596 ( 4.2A)
EST  A 596 (-4.0A)
EST  A 596 (-3.6A)
0.97A30.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens)		8 / 12ALA A 271
ALA A 272
GLN A 275
TRP A 305
LEU A 309
ARG A 316
LEU A 326
LEU A 436
9CR  A7223 (-3.5A)
9CR  A7223 (-4.2A)
9CR  A7223 (-4.6A)
None
9CR  A7223 ( 4.4A)
9CR  A7223 (-3.7A)
9CR  A7223 (-3.8A)
9CR  A7223 ( 4.7A)
0.78A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens)		9 / 12ALA A 271
ALA A 272
TRP A 305
LEU A 309
ARG A 316
LEU A 326
VAL A 342
ILE A 345
LEU A 436
9CR  A7223 (-3.5A)
9CR  A7223 (-4.2A)
None
9CR  A7223 ( 4.4A)
9CR  A7223 (-3.7A)
9CR  A7223 (-3.8A)
9CR  A7223 ( 4.5A)
9CR  A7223 ( 4.9A)
9CR  A7223 ( 4.7A)
0.74A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens)		6 / 12ALA A 271
GLN A 275
TRP A 305
ARG A 316
LEU A 326
ILE A 428
9CR  A7223 (-3.5A)
9CR  A7223 (-4.6A)
None
9CR  A7223 (-3.7A)
9CR  A7223 (-3.8A)
None
1.35A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens)		7 / 12ALA A 271
LEU A 309
ARG A 316
LEU A 326
VAL A 342
ILE A 345
CYH A 432
9CR  A7223 (-3.5A)
9CR  A7223 ( 4.4A)
9CR  A7223 (-3.7A)
9CR  A7223 (-3.8A)
9CR  A7223 ( 4.5A)
9CR  A7223 ( 4.9A)
9CR  A7223 (-3.8A)
0.93A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens)		5 / 12ALA A 111
GLN A 143
LEU A 144
VAL A 162
LEU A 128
None
None
None
MES  A 361 (-3.6A)
None
0.94A21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		3o10 SACSIN
(Homo
sapiens)		5 / 12ALA A4487
ALA A4488
LEU A4451
ALA A4447
LEU A4519
None
0.76A17.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1
(Homo
sapiens)		9 / 12ALA D 271
ALA D 272
GLN D 275
LEU D 309
ARG D 316
LEU D 326
VAL D 342
ILE D 345
CYH D 432
None
0.87A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1
(Homo
sapiens)		10 / 12ALA D 271
ALA D 272
GLN D 275
TRP D 305
LEU D 309
ARG D 316
LEU D 326
VAL D 342
ILE D 345
LEU D 436
None
0.67A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1
(Homo
sapiens)		9 / 12ALA D 271
GLN D 275
LEU D 309
ARG D 316
LEU D 326
ALA D 327
VAL D 342
ILE D 345
CYH D 432
None
0.99A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1
(Homo
sapiens)		7 / 12ALA D 271
GLN D 275
TRP D 305
ARG D 316
LEU D 326
ALA D 327
ILE D 428
None
1.43A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1
(Homo
sapiens)		10 / 12ALA D 271
GLN D 275
TRP D 305
LEU D 309
ARG D 316
LEU D 326
ALA D 327
VAL D 342
ILE D 345
LEU D 436
None
0.80A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		4qpn PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21B
(Homo
sapiens)		5 / 12ALA A 179
LEU A  63
ALA A  59
ILE A  80
LEU A 166
None
0.73A17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3
(Homo
sapiens)		5 / 12LEU A 339
VAL A 290
ILE A 281
CYH A 278
LEU A 239
None
1.00A21.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		5toa ESTROGEN RECEPTOR
BETA
(Homo
sapiens)		5 / 12ALA A 302
LEU A 339
VAL A 370
ILE A 373
LEU A 476
EST  A 601 ( 3.9A)
EST  A 601 (-3.9A)
None
None
EST  A 601 (-3.5A)
0.95A30.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens)		12 / 12ALA A 271
ALA A 272
GLN A 275
TRP A 305
LEU A 309
ARG A 316
LEU A 326
ALA A 327
VAL A 342
ILE A 345
CYH A 432
LEU A 436
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
None
9CR  A 503 (-3.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
None
9CR  A 503 (-3.3A)
9CR  A 503 ( 4.8A)
0.70A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		1uhl RETINOIC ACID
RECEPTOR RXR-BETA
(Homo
sapiens)		3 / 3ILE A 339
PHE A 384
HIS A 506
MEI  A1001 (-3.8A)
MEI  A1001 (-4.5A)
None
0.52A88.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		1xls RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens)		3 / 3ILE A 268
PHE A 313
HIS A 435
9CR  A 801 (-3.9A)
9CR  A 801 (-4.3A)
None
0.54A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		1z6y ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
5
(Homo
sapiens)		3 / 3ILE A  88
PHE A  36
HIS A 153
None
0.67A21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		2qfb PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens)		3 / 3ILE A 862
PHE A 838
HIS A 871
None
0.63A20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens)		3 / 3ILE A 379
PHE A 382
HIS A 449
None
0.70A22.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens)		3 / 3ILE A 268
PHE A 313
HIS A 435
9CR  A7223 (-3.9A)
9CR  A7223 (-4.5A)
9CR  A7223 (-4.3A)
0.66A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		3lrn PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens)		3 / 3ILE A 862
PHE A 838
HIS A 871
None
0.58A21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens)		3 / 3ILE A 862
PHE A 838
HIS A 871
None
0.67A16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		4fgu LEGUMAIN
(Homo
sapiens)		3 / 3ILE A  56
PHE A 142
HIS A  51
None
0.59A20.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1
(Homo
sapiens)		3 / 3ILE D 268
PHE D 313
HIS D 435
None
0.61A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		4m47 DNA POLYMERASE BETA
(Homo
sapiens)		3 / 3ILE A 255
PHE A 235
HIS A 252
None
0.76A23.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		1lv2 HEPATOCYTE NUCLEAR
FACTOR 4-GAMMA
(Homo
sapiens)		5 / 12GLN A 145
LEU A 179
ARG A 186
LEU A 196
VAL A 218
PLM  A 328 ( 4.8A)
PLM  A 328 ( 4.6A)
PLM  A 328 (-3.3A)
PLM  A 328 (-3.7A)
None
0.71A40.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		1uhl RETINOIC ACID
RECEPTOR RXR-BETA
(Homo
sapiens)		11 / 12ILE A 339
ALA A 342
ALA A 343
GLN A 346
LEU A 380
ILE A 381
PHE A 384
ARG A 387
LEU A 397
ALA A 398
VAL A 420
MEI  A1001 (-3.8A)
MEI  A1001 (-3.1A)
MEI  A1001 (-3.3A)
None
MEI  A1001 (-3.8A)
MEI  A1001 ( 4.9A)
MEI  A1001 (-4.5A)
MEI  A1001 (-3.6A)
MEI  A1001 ( 4.4A)
MEI  A1001 (-3.4A)
None
0.46A88.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		1uhl RETINOIC ACID
RECEPTOR RXR-BETA
(Homo
sapiens)		8 / 12ILE A 339
GLN A 346
ILE A 381
PHE A 384
ARG A 387
LEU A 397
ALA A 398
CYH A 503
MEI  A1001 (-3.8A)
None
MEI  A1001 ( 4.9A)
MEI  A1001 (-4.5A)
MEI  A1001 (-3.6A)
MEI  A1001 ( 4.4A)
MEI  A1001 (-3.4A)
MEI  A1001 (-4.0A)
0.91A88.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		1uhl RETINOIC ACID
RECEPTOR RXR-BETA
(Homo
sapiens)		5 / 12LEU A 380
ILE A 381
PHE A 384
ALA A 342
VAL A 420
MEI  A1001 (-3.8A)
MEI  A1001 ( 4.9A)
MEI  A1001 (-4.5A)
MEI  A1001 (-3.1A)
None
1.03A88.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		1xls RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens)		11 / 12ILE A 268
ALA A 271
ALA A 272
GLN A 275
LEU A 309
ILE A 310
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 349
9CR  A 801 (-3.9A)
9CR  A 801 (-3.6A)
9CR  A 801 (-3.5A)
9CR  A 801 (-4.7A)
9CR  A 801 (-4.2A)
None
9CR  A 801 (-4.3A)
9CR  A 801 (-2.6A)
9CR  A 801 (-4.1A)
9CR  A 801 (-3.3A)
None
0.37A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		1xls RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens)		9 / 12ILE A 268
ALA A 271
LEU A 309
ILE A 310
PHE A 313
ARG A 316
LEU A 326
ALA A 327
CYH A 432
9CR  A 801 (-3.9A)
9CR  A 801 (-3.6A)
9CR  A 801 (-4.2A)
None
9CR  A 801 (-4.3A)
9CR  A 801 (-2.6A)
9CR  A 801 (-4.1A)
9CR  A 801 (-3.3A)
9CR  A 801 ( 3.7A)
0.69A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		1xls RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens)		5 / 12LEU A 309
ILE A 310
PHE A 313
ALA A 271
VAL A 349
9CR  A 801 (-4.2A)
None
9CR  A 801 (-4.3A)
9CR  A 801 (-3.6A)
None
1.06A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		2gl8 RETINOIC ACID
RECEPTOR RXR-GAMMA
(Homo
sapiens)		6 / 12LEU A  88
ILE A  89
PHE A  92
ARG A  95
ALA A 106
VAL A 128
None
0.61A88.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens)		9 / 12ALA A 271
ALA A 272
GLN A 275
LEU A 309
ILE A 310
PHE A 313
ARG A 316
LEU A 326
VAL A 349
9CR  A7223 (-3.5A)
9CR  A7223 (-4.2A)
9CR  A7223 (-4.6A)
9CR  A7223 ( 4.4A)
None
9CR  A7223 (-4.5A)
9CR  A7223 (-3.7A)
9CR  A7223 (-3.8A)
None
0.51A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens)		8 / 12GLN A 275
LEU A 309
ILE A 310
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 349
9CR  A7223 (-4.6A)
9CR  A7223 ( 4.4A)
None
9CR  A7223 (-4.5A)
9CR  A7223 (-3.7A)
9CR  A7223 (-3.8A)
9CR  A7223 ( 4.7A)
None
0.63A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens)		9 / 12ILE A 268
ALA A 271
ALA A 272
GLN A 275
LEU A 309
ILE A 310
PHE A 313
ARG A 316
VAL A 349
9CR  A7223 (-3.9A)
9CR  A7223 (-3.5A)
9CR  A7223 (-4.2A)
9CR  A7223 (-4.6A)
9CR  A7223 ( 4.4A)
None
9CR  A7223 (-4.5A)
9CR  A7223 (-3.7A)
None
0.54A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens)		5 / 12ILE A 268
ILE A 310
PHE A 313
ARG A 316
CYH A 432
9CR  A7223 (-3.9A)
None
9CR  A7223 (-4.5A)
9CR  A7223 (-3.7A)
9CR  A7223 (-3.8A)
1.01A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens)		5 / 12ILE A 310
PHE A 313
ARG A 316
LEU A 326
CYH A 432
None
9CR  A7223 (-4.5A)
9CR  A7223 (-3.7A)
9CR  A7223 (-3.8A)
9CR  A7223 (-3.8A)
0.95A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens)		5 / 12LEU A 309
ILE A 310
PHE A 313
ALA A 271
VAL A 349
9CR  A7223 ( 4.4A)
None
9CR  A7223 (-4.5A)
9CR  A7223 (-3.5A)
None
1.10A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		3hve GIGAXONIN
(Homo
sapiens)		5 / 12ILE A  47
ALA A  50
ALA A  51
LEU B  20
ALA B  19
None
0.54A21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens)		5 / 12ALA A 177
PHE A 182
ALA A  69
VAL A 120
CYH A 166
None
1.09A22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL
(Homo
sapiens)		5 / 12ILE A 290
ALA A 288
ILE A 202
ALA A 217
VAL A 329
None
1.00A16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		3tx7 NUCLEAR RECEPTOR
SUBFAMILY 5 GROUP A
MEMBER 2
(Homo
sapiens)		5 / 12ALA B 349
LEU B 386
ILE B 387
ARG B 393
LEU B 405
P6L  B 100 ( 3.9A)
P6L  B 100 (-3.8A)
None
None
None
0.80A28.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1
(Homo
sapiens)		11 / 12ILE D 268
ALA D 271
ALA D 272
GLN D 275
LEU D 309
ILE D 310
PHE D 313
ARG D 316
LEU D 326
ALA D 327
VAL D 349
None
0.55A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1
(Homo
sapiens)		9 / 12ILE D 268
ALA D 271
GLN D 275
ILE D 310
PHE D 313
ARG D 316
LEU D 326
ALA D 327
CYH D 432
None
0.84A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens)		5 / 12ALA A 186
PHE A 191
ALA A  78
VAL A 129
CYH A 175
None
1.09A19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		5l0j VINCULIN
(Homo
sapiens)		5 / 12ILE A 919
ALA A 922
ALA A 923
ALA A 957
VAL A 984
None
0.70A21.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens)		12 / 12ILE A 268
ALA A 271
ALA A 272
GLN A 275
LEU A 309
ILE A 310
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 349
CYH A 432
9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
9CR  A 503 (-3.7A)
9CR  A 503 ( 4.8A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
0.52A100.00