POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		1kq0 METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens)		4 / 7GLY A 330
HIS A 331
ASP A 262
HIS A 231
None
ZN  A 480 ( 3.4A)
ZN  A 479 (-2.2A)
MED  A 601 (-4.2A)
0.82A10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		1uwy CARBOXYPEPTIDASE M
(Homo
sapiens)		4 / 7ASP A 250
GLY A 247
ASP A 184
ASN A 252
None
0.91A11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		2adu METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens)		4 / 7GLY A 330
HIS A 331
ASP A 262
HIS A 231
None
CO  A 502 ( 3.2A)
CO  A 501 (-2.2A)
R20  A 906 (-4.4A)
0.79A12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		2n51 ELONGATION FACTOR
1-DELTA
(Homo
sapiens)		4 / 7ASP A 155
GLY A 149
ASP A 154
ASP A 156
None
1.09A18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens)		4 / 7ASP A 274
GLY A 271
ASP A 207
ASN A 276
None
0.97A10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		2yrt CHORD CONTAINING
PROTEIN-1
(Homo
sapiens)		4 / 7ASP A  28
GLY A  69
ASP A  29
ASN A  26
None
0.93A18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		4hxx METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens)		4 / 7GLY A 302
HIS A 303
ASP A 240
HIS A 212
None
CO  A 401 (-3.3A)
CO  A 402 ( 2.3A)
CO  A 403 ( 3.3A)
0.70A12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		4iu6 METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens)		4 / 7GLY A 302
HIS A 303
ASP A 240
HIS A 212
None
CO  A 401 (-3.1A)
CO  A 402 ( 2.2A)
CO  A 403 ( 3.1A)
0.79A11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1
(Homo
sapiens)		4 / 7ASP A 350
GLY A 209
HIS A 352
HIS A 242
LLP  A 353 ( 3.8A)
LLP  A 353 ( 4.2A)
LLP  A 353 ( 4.0A)
LLP  A 353 (-3.6A)
1.00A10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens)		4 / 7ASP A 340
GLY A 339
HIS A 338
ASP A 358
None
None
None
DL1  A 601 (-3.1A)
1.05A21.43