POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		1t5i C_TERMINAL DOMAIN OF
A PROBABLE
ATP-DEPENDENT RNA
HELICASE
(Homo
sapiens)		4 / 8TYR A 371
VAL A 403
LEU A 262
ILE A 411
None
1.00A15.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		1tf0 SERUM ALBUMIN
(Homo
sapiens)		5 / 8LEU A 115
TYR A 138
ARG A 145
HIS A 146
LEU A 182
None
0.61A76.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		1xjv PROTECTION OF
TELOMERES 1
(Homo
sapiens)		4 / 8VAL A 222
HIS A 226
LEU A 164
ILE A 275
None
0.86A19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		1xkt FATTY ACID SYNTHASE
(Homo
sapiens)		4 / 8LEU A2427
TYR A2309
LEU A2279
ILE A2282
None
0.99A17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		1xtj PROBABLE
ATP-DEPENDENT RNA
HELICASE P47
(Homo
sapiens)		4 / 8TYR A 371
VAL A 403
LEU A 262
ILE A 411
None
0.67A20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens)		4 / 8VAL A 718
ARG A 721
LEU A 701
ILE A 686
None
1.01A20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		2fv2 RCD1 REQUIRED FOR
CELL
DIFFERENTIATION1
HOMOLOG
(Homo
sapiens)		4 / 8LEU A  36
VAL A  84
LEU A  13
ILE A  47
None
1.00A20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		2mbg RALA-BINDING PROTEIN
1
(Homo
sapiens)		4 / 8LEU A 267
VAL A 220
LEU A 346
ILE A 230
None
0.85A18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		2q3z TRANSGLUTAMINASE 2
(Homo
sapiens)		4 / 8LEU A 311
VAL A 563
ARG A 564
ILE A 477
None
0.99A21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		2qag SEPTIN-2
(Homo
sapiens)		4 / 8LEU A 200
HIS A 212
LEU A 160
ILE A 210
None
1.02A21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE
(Homo
sapiens)		4 / 8LEU A 851
HIS A 752
LEU A 544
ILE A 756
None
0.95A22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		2vd5 DMPK PROTEIN
(Homo
sapiens)		4 / 8LEU A 325
ARG A 316
LEU A 264
ILE A 314
None
0.93A22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		3coi MITOGEN-ACTIVATED
PROTEIN KINASE 13
(Homo
sapiens)		4 / 8LEU A 167
VAL A  84
LEU A 151
ILE A 141
None
0.89A19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		3dxb THIOREDOXIN
N-TERMINALLY FUSED
TO PUF60(UHM)
(Escherichia
coli;
Homo
sapiens)		4 / 8LEU A 386
HIS A 350
LEU A 397
ILE A 349
None
CL  A   1 (-4.5A)
None
None
0.85A17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B
(Homo
sapiens)		4 / 8LEU A 584
VAL A 962
LEU A 998
ILE A 926
None
0.72A20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		3hve GIGAXONIN
(Homo
sapiens)		4 / 8LEU A 178
VAL A 181
LEU A 171
ILE A 135
None
0.92A18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens)		4 / 8LEU A2392
ARG A2397
HIS A2401
LEU A2324
None
1.01A20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		3pzd MYOSIN-X
(Homo
sapiens)		4 / 8LEU A1838
VAL A1854
ARG A1834
ILE A1924
None
0.99A22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		3rbn DNA MISMATCH REPAIR
PROTEIN MLH1
(Homo
sapiens)		4 / 8LEU A  92
TYR A 179
VAL A 253
ILE A 219
None
0.94A19.32