POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Seq. Identity (%)	View	Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5Y2O_A_8N6A501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	2daw	RWD DOMAIN CONTAINING PROTEIN 2 (Homo sapiens)	5 / 12	LEU A  44 PHE A  64 LEU A  92 LEU A 125 TYR A  87	None	1.28A	30.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Y2O_A_8N6A501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	2p54	PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR ALPHA (Homo sapiens)	7 / 12	CYH A 276 SER A 280 LEU A 321 MET A 355 HIS A 440 LEU A 460 TYR A 464	735  A 469 (-2.9A) 735  A 469 (-2.8A) 735  A 469 ( 4.3A) 735  A 469 (-2.9A) 735  A 469 (-4.0A) 735  A 469 (-4.3A) 735  A 469 (-4.6A)	0.72A	12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Y2O_A_8N6A501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	2p54	PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR ALPHA (Homo sapiens)	7 / 12	PHE A 273 CYH A 276 SER A 280 LEU A 321 MET A 355 LEU A 460 TYR A 464	735  A 469 (-3.7A) 735  A 469 (-2.9A) 735  A 469 (-2.8A) 735  A 469 ( 4.3A) 735  A 469 (-2.9A) 735  A 469 (-4.3A) 735  A 469 (-4.6A)	0.82A	12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Y2O_A_8N6A501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	2p5x	N-ACETYLSEROTONIN O-METHYLTRANSFERASE- LIKE PROTEIN (Homo sapiens)	5 / 12	PHE A 204 HIS A 129 LEU A  10 LEU A 211 TYR A 212	None	1.29A	19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Y2O_A_8N6A501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	2xwu	IMPORTIN13 (Homo sapiens)	5 / 12	TYR B 390 LEU B 393 PHE B 363 LEU B 324 LEU B 334	None	1.17A	6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Y2O_A_8N6A501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	2z7x	TOLL-LIKE RECEPTOR 1, VARIABLE LYMPHOCYTE RECEPTOR B (Eptatretus burgeri; Homo sapiens)	5 / 12	PHE B 233 LEU B 171 PHE B 202 LEU B 251 LEU B 216	None	1.36A	14.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5Y2O_A_8N6A501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	3b0q	PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA (Homo sapiens)	6 / 12	PHE A 282 CYH A 285 LEU A 330 PHE A 363 MET A 364 LEU A 453	MC5  A   1 (-4.4A) MC5  A   1 (-3.6A) MC5  A   1 (-4.4A) None MC5  A   1 (-3.7A) MC5  A   1 (-4.2A)	0.90A	73.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5Y2O_A_8N6A501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	3b0q	PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA (Homo sapiens)	5 / 12	PHE A 282 CYH A 285 MET A 364 HIS A 449 LEU A 465	MC5  A   1 (-4.4A) MC5  A   1 (-3.6A) MC5  A   1 (-3.7A) MC5  A   1 (-3.9A) None	1.50A	73.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5Y2O_A_8N6A501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	3b0q	PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA (Homo sapiens)	11 / 12	PHE A 282 CYH A 285 SER A 289 HIS A 323 TYR A 327 LEU A 330 MET A 364 HIS A 449 LEU A 453 LEU A 469 TYR A 473	MC5  A   1 (-4.4A) MC5  A   1 (-3.6A) MC5  A   1 (-2.6A) MC5  A   1 (-3.8A) None MC5  A   1 (-4.4A) MC5  A   1 (-3.7A) MC5  A   1 (-3.9A) MC5  A   1 (-4.2A) MC5  A   1 (-4.1A) MC5  A   1 (-4.9A)	0.57A	73.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Y2O_A_8N6A501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	3d5f	PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR DELTA (Homo sapiens)	6 / 12	CYH A 285 HIS A 323 LEU A 330 HIS A 449 LEU A 469 TYR A 473	L41  A 501 (-3.5A) L41  A 501 (-3.8A) L41  A 501 (-4.9A) L41  A 501 (-3.9A) L41  A 501 (-3.8A) L41  A 501 (-4.8A)	0.63A	12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Y2O_A_8N6A501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	3d5f	PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR DELTA (Homo sapiens)	6 / 12	PHE A 282 CYH A 285 HIS A 323 LEU A 330 LEU A 469 TYR A 473	L41  A 501 ( 4.9A) L41  A 501 (-3.5A) L41  A 501 (-3.8A) L41  A 501 (-4.9A) L41  A 501 (-3.8A) L41  A 501 (-4.8A)	0.70A	12.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5Y2O_A_8N6A501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	3dzu	PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA (Homo sapiens)	5 / 12	CYH D 285 TYR D 327 LEU D 330 MET D 364 HIS D 449	PLB  D 701 (-3.2A) None PLB  D 701 ( 4.1A) PLB  D 701 ( 4.8A) None	0.94A	35.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5Y2O_A_8N6A501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	3dzu	PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA (Homo sapiens)	6 / 12	PHE D 282 SER D 289 LEU D 330 MET D 364 LEU D 469 TYR D 473	None PLB  D 701 ( 3.9A) PLB  D 701 ( 4.1A) PLB  D 701 ( 4.8A) None None	0.61A	35.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5Y2O_A_8N6A501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	3dzu	PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA (Homo sapiens)	6 / 12	SER D 289 LEU D 330 MET D 364 HIS D 449 LEU D 469 TYR D 473	PLB  D 701 ( 3.9A) PLB  D 701 ( 4.1A) PLB  D 701 ( 4.8A) None None None	0.67A	35.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5Y2O_A_8N6A501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	3dzu	PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA (Homo sapiens)	6 / 12	TYR D 327 LEU D 330 MET D 364 HIS D 449 LEU D 469 TYR D 473	None PLB  D 701 ( 4.1A) PLB  D 701 ( 4.8A) None None None	0.90A	35.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Y2O_A_8N6A501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	3fxi	TOLL-LIKE RECEPTOR 4 (Homo sapiens)	5 / 12	CYH A 246 PHE A 237 MET A 215 LEU A 260 LEU A 283	None	1.42A	8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Y2O_A_8N6A501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	3hfw	PROTEIN ADP-RIBOSYLARGININE HYDROLASE (Homo sapiens)	5 / 12	PHE A 142 LEU A 173 LEU A  76 LEU A  83 TYR A  80	None	1.26A	11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Y2O_A_8N6A501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	4c0d	CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1 (Homo sapiens)	5 / 12	PHE A2023 CYH A2020 PHE A2047 MET A2051 LEU A1967	None	1.22A	7.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Y2O_A_8N6A501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	5ec3	4-HYDROXYPHENYLPYRUV ATE DIOXYGENASE (Homo sapiens)	5 / 12	PHE A  42 LEU A 346 PHE A  69 LEU A 178 LEU A 286	PHE  A  42 ( 1.3A) LEU  A 346 ( 0.6A) PHE  A  69 ( 1.3A) LEU  A 178 ( 0.6A) LEU  A 286 ( 0.6A)	1.35A	9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Y2O_A_8N6A501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	5fu7	CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1 (Homo sapiens)	5 / 12	PHE A2023 CYH A2020 PHE A2047 MET A2051 LEU A1967	None	1.09A	9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Y2O_A_8N6A501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	5hdt	SISTER CHROMATID COHESION PROTEIN PDS5 HOMOLOG B (Homo sapiens)	5 / 12	LEU A 536 PHE A 549 MET A 546 LEU A 510 LEU A 566	None	1.22A	5.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Y2O_A_8N6A501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	6d0s	TBC1 DOMAIN FAMILY MEMBER 22B (Homo sapiens)	5 / 12	CYH A 445 TYR A 430 MET A 410 LEU A 418 LEU A 485	None	1.39A	26.60