POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		1jmo HEPARIN COFACTOR II
(Homo
sapiens)		5 / 11VAL A 221
PHE A 217
GLY A 144
ILE A 270
LEU A 205
None
0.91A21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens)		5 / 11PHE A 365
PHE A 361
ILE A 382
LEU A 433
PHE A 378
None
1.06A19.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		2pg6 CYTOCHROME P450 2A6
(Homo
sapiens)		10 / 11PHE A 107
PHE A 111
VAL A 117
PHE A 118
ILE A 300
GLY A 301
THR A 305
ILE A 366
LEU A 370
PHE A 480
None
None
HEM  A 500 (-3.7A)
None
None
HEM  A 500 ( 4.7A)
HEM  A 500 (-3.6A)
HEM  A 500 ( 4.1A)
HEM  A 500 ( 3.8A)
None
0.29A99.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		3bn9 E2 FAB HEAVY CHAIN
(Homo
sapiens)		6 / 11PHE D  29
ASN D  73
GLY D  54
THR D  57
ILE D  69
LEU D  78
None
1.48A17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE
(Homo
sapiens)		5 / 11PHE A 117
PHE A 118
GLY A  97
ILE A 172
LEU A 174
None
HIU  A 502 (-4.8A)
HIU  A 502 ( 3.5A)
QUE  A 501 (-3.9A)
HIU  A 502 (-4.9A)
1.05A22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		3ihy PHOSPHATIDYLINOSITOL
3-KINASE CATALYTIC
SUBUNIT TYPE 3
(Homo
sapiens)		5 / 11VAL A 842
PHE A 820
ILE A 765
GLY A 740
ILE A 735
None
1.03A22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		3kq4 CUBILIN
(Homo
sapiens)		5 / 11PHE B1270
PHE B1210
PHE B1207
LEU B1205
PHE B1176
None
0.94A21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		3u15 PROTEIN MDM4
(Homo
sapiens)		5 / 11VAL A  74
PHE A  90
GLY A  57
ILE A  36
LEU A  81
None
None
03M  A   1 ( 4.0A)
None
None
1.06A11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		3unn MEDIATOR OF DNA
DAMAGE CHECKPOINT
PROTEIN 1
(Homo
sapiens)		5 / 11VAL A  64
ILE A  71
THR A  98
ILE A 121
LEU A  34
None
1.05A13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		4dyo ASPARTYL
AMINOPEPTIDASE
(Homo
sapiens)		5 / 11VAL A 429
ILE A  91
GLY A  92
THR A 296
LEU A 427
None
1.06A21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens)		5 / 11VAL A 280
ILE A 207
GLY A 208
LEU A 277
PHE A 112
None
0.88A22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens)		5 / 11VAL A 280
ILE A 207
GLY A 208
LEU A 277
PHE A 112
None
0.88A21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		4uu9 MEDI7814
(Homo
sapiens)		6 / 11PHE A  29
ASN A  73
GLY A  54
THR A  57
ILE A  69
LEU A  78
None
1.46A11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		5vk1 PROTEIN MDM4
(Homo
sapiens)		5 / 11VAL A  74
PHE A  90
GLY A  57
ILE A  36
LEU A  81
None
1.06Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		1gg3 ERYTHROID MEMBRANE
PROTEIN 4.1R
(Homo
sapiens)		5 / 11PHE A 223
ILE A 254
GLY A 255
ILE A 202
LEU A 204
None
0.93A19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		1jmo HEPARIN COFACTOR II
(Homo
sapiens)		5 / 11VAL A 221
PHE A 217
GLY A 144
ILE A 270
LEU A 205
None
0.93A21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		1ttx ONCOMODULIN
(Homo
sapiens)		5 / 11PHE A  30
VAL A 107
PHE A  31
ILE A  51
PHE A  67
None
1.05A12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens)		5 / 11PHE A 365
PHE A 361
ILE A 382
LEU A 433
PHE A 378
None
1.06A19.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		2pg6 CYTOCHROME P450 2A6
(Homo
sapiens)		10 / 11PHE A 107
PHE A 111
VAL A 117
PHE A 118
ILE A 300
GLY A 301
THR A 305
ILE A 366
LEU A 370
PHE A 480
None
None
HEM  A 500 (-3.7A)
None
None
HEM  A 500 ( 4.7A)
HEM  A 500 (-3.6A)
HEM  A 500 ( 4.1A)
HEM  A 500 ( 3.8A)
None
0.34A99.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		3bin BAND 4.1-LIKE
PROTEIN 3
(Homo
sapiens)		5 / 11PHE A 332
ILE A 363
GLY A 364
ILE A 311
LEU A 313
None
1.07A20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE
(Homo
sapiens)		5 / 11PHE A 117
PHE A 118
GLY A  97
ILE A 172
LEU A 174
None
HIU  A 502 (-4.8A)
HIU  A 502 ( 3.5A)
QUE  A 501 (-3.9A)
HIU  A 502 (-4.9A)
1.05A22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		3hi5 HEAVY CHAIN OF FAB
FRAGMENT OF AL-57
AGAINST ALPHA L I
DOMAIN
(Homo
sapiens)		6 / 11PHE H  29
ASN H  74
GLY H  55
THR H  58
ILE H  70
LEU H  79
None
1.43A17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		3ihy PHOSPHATIDYLINOSITOL
3-KINASE CATALYTIC
SUBUNIT TYPE 3
(Homo
sapiens)		5 / 11VAL A 842
PHE A 820
ILE A 765
GLY A 740
ILE A 735
None
1.04A22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		3kq4 CUBILIN
(Homo
sapiens)		5 / 11PHE B1270
PHE B1210
PHE B1207
LEU B1205
PHE B1176
None
0.93A21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		3u15 PROTEIN MDM4
(Homo
sapiens)		5 / 11VAL A  74
PHE A  90
GLY A  57
ILE A  36
LEU A  81
None
None
03M  A   1 ( 4.0A)
None
None
1.03A11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens)		5 / 11VAL A 280
ILE A 207
GLY A 208
LEU A 277
PHE A 112
None
0.96A22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		5dr5 ABD09097 FAB HEAVY
CHAIN
(Homo
sapiens)		6 / 11PHE H  29
ASN H  74
GLY H  55
THR H  58
ILE H  70
LEU H  79
None
1.47A19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		5vk1 PROTEIN MDM4
(Homo
sapiens)		5 / 11VAL A  74
PHE A  90
GLY A  57
ILE A  36
LEU A  81
None
1.06Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		1gg3 ERYTHROID MEMBRANE
PROTEIN 4.1R
(Homo
sapiens)		5 / 10PHE A 223
ILE A 254
GLY A 255
ILE A 202
LEU A 204
None
0.99A19.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		2pg6 CYTOCHROME P450 2A6
(Homo
sapiens)		9 / 10PHE A 107
PHE A 111
VAL A 117
ILE A 300
GLY A 301
THR A 305
ILE A 366
LEU A 370
PHE A 480
None
None
HEM  A 500 (-3.7A)
None
HEM  A 500 ( 4.7A)
HEM  A 500 (-3.6A)
HEM  A 500 ( 4.1A)
HEM  A 500 ( 3.8A)
None
0.36A99.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens)		5 / 10PHE A 372
VAL A 375
GLY A 120
ILE A  48
LEU A  57
None
1.02A23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		3unn MEDIATOR OF DNA
DAMAGE CHECKPOINT
PROTEIN 1
(Homo
sapiens)		5 / 10VAL A  64
ILE A  71
THR A  98
ILE A 121
LEU A  34
None
1.10A13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		4dyo ASPARTYL
AMINOPEPTIDASE
(Homo
sapiens)		5 / 10VAL A 429
ILE A  91
GLY A  92
THR A 296
LEU A 427
None
1.07A21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens)		5 / 10VAL A 280
ILE A 207
GLY A 208
LEU A 277
PHE A 112
None
0.95A22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens)		5 / 10VAL A 280
ILE A 207
GLY A 208
LEU A 277
PHE A 112
None
0.95A21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		4wmy INTELECTIN-1
(Homo
sapiens)		5 / 10ILE A 149
GLY A 148
THR A 171
LEU A 183
PHE A 238
None
1.14A18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		5hcc COMPLEMENT C5
(Homo
sapiens)		5 / 10ILE A1381
THR A1383
ILE A1479
LEU A1428
PHE A1477
None
1.13A19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		5swk E3 UBIQUITIN-PROTEIN
LIGASE MDM2
(Homo
sapiens)		5 / 10ILE A  61
GLY A  58
ILE A 103
LEU A  34
PHE A  86
None
1.14A17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		1gg3 ERYTHROID MEMBRANE
PROTEIN 4.1R
(Homo
sapiens)		5 / 10PHE A 223
ILE A 254
GLY A 255
ILE A 202
LEU A 204
None
1.01A19.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		2pg6 CYTOCHROME P450 2A6
(Homo
sapiens)		9 / 10PHE A 107
PHE A 111
VAL A 117
ILE A 300
GLY A 301
THR A 305
ILE A 366
LEU A 370
PHE A 480
None
None
HEM  A 500 (-3.7A)
None
HEM  A 500 ( 4.7A)
HEM  A 500 (-3.6A)
HEM  A 500 ( 4.1A)
HEM  A 500 ( 3.8A)
None
0.32A99.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		2vn8 RETICULON-4-INTERACT
ING PROTEIN 1
(Homo
sapiens)		5 / 10PHE A 372
VAL A 375
GLY A 120
ILE A  48
LEU A  57
None
1.10A23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		3dkp PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX52
(Homo
sapiens)		5 / 10VAL A 312
ILE A 307
THR A 291
ILE A 240
LEU A 315
None
1.11A21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		3unn MEDIATOR OF DNA
DAMAGE CHECKPOINT
PROTEIN 1
(Homo
sapiens)		5 / 10VAL A  64
ILE A  71
THR A  98
ILE A 121
LEU A  34
None
1.06A13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		4dyo ASPARTYL
AMINOPEPTIDASE
(Homo
sapiens)		5 / 10VAL A 429
ILE A  91
GLY A  92
THR A 296
LEU A 427
None
1.06A21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens)		5 / 10VAL A 280
ILE A 207
GLY A 208
LEU A 277
PHE A 112
None
0.94A22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens)		5 / 10VAL A 280
ILE A 207
GLY A 208
LEU A 277
PHE A 112
None
0.93A21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri;
Homo
sapiens)		6 / 10PHE A 240
ASN A 258
ILE A 260
ILE A 277
LEU A 253
PHE A 268
None
1.49A21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		4wmy INTELECTIN-1
(Homo
sapiens)		5 / 10ILE A 149
GLY A 148
THR A 171
LEU A 183
PHE A 238
None
1.07A18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		5hcc COMPLEMENT C5
(Homo
sapiens)		5 / 10ILE A1381
THR A1383
ILE A1479
LEU A1428
PHE A1477
None
1.11A19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		5yhu MYELIN REGULATORY
FACTOR
(Homo
sapiens)		5 / 10VAL A 395
GLY A 375
ILE A 518
LEU A 495
PHE A 472
None
1.08Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		5zhu MYELIN REGULATORY
FACTOR
(Homo
sapiens)		5 / 10VAL A 395
GLY A 375
ILE A 518
LEU A 495
PHE A 472
None
1.10Aundetectable