POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		1i4e CASPASE-8
(Homo
sapiens)		5 / 12LEU B2440
PHE B2355
GLY B2402
LEU B2270
LEU B2296
None
1.11Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		1u6g TIP120 PROTEIN
(Homo
sapiens)		5 / 12LEU C 218
GLY C 200
LEU C 155
ILE C 196
LEU C 169
None
1.16Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2
(Homo
sapiens)		5 / 12LEU B2218
GLY B2200
GLN B2204
ILE B2193
MET B2186
None
1.24Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens)		5 / 12LEU A 247
CYH A 276
LEU A 321
MET A 355
HIS A 440
None
735  A 469 (-2.9A)
735  A 469 ( 4.3A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
0.84Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens)		6 / 12LEU A 247
PHE A 273
CYH A 276
GLN A 277
LEU A 321
MET A 355
None
735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-4.4A)
735  A 469 ( 4.3A)
735  A 469 (-2.9A)
0.72Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens)		5 / 12PHE A 273
CYH A 276
GLN A 277
LEU A 321
ILE A 339
735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-4.4A)
735  A 469 ( 4.3A)
735  A 469 ( 4.1A)
1.23Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		2rsv SERINE/THREONINE-PRO
TEIN KINASE VRK1
(Homo
sapiens)		5 / 12LEU A 309
LEU A 155
ILE A 323
MET A 251
LEU A 183
None
1.17Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)		6 / 12LEU A 255
CYH A 285
LEU A 330
ILE A 341
MET A 348
LEU A 465
None
MC5  A   1 (-3.6A)
MC5  A   1 (-4.4A)
MC5  A   1 (-4.5A)
MC5  A   1 ( 4.0A)
None
1.23Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)		12 / 12LEU A 255
PHE A 282
GLY A 284
CYH A 285
GLN A 286
TYR A 327
LEU A 330
ILE A 341
MET A 348
MET A 364
HIS A 449
LEU A 453
None
MC5  A   1 (-4.4A)
MC5  A   1 ( 4.5A)
MC5  A   1 (-3.6A)
None
None
MC5  A   1 (-4.4A)
MC5  A   1 (-4.5A)
MC5  A   1 ( 4.0A)
MC5  A   1 (-3.7A)
MC5  A   1 (-3.9A)
MC5  A   1 (-4.2A)
0.60Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA
(Homo
sapiens)		5 / 12LEU A 255
PHE A 282
CYH A 285
GLN A 286
LEU A 330
None
L41  A 501 ( 4.9A)
L41  A 501 (-3.5A)
None
L41  A 501 (-4.9A)
0.60Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3dyt SORTING NEXIN-9
(Homo
sapiens)		5 / 12PHE A 503
GLY A 501
CYH A 502
LEU A 298
LEU A 548
None
1.27Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)		5 / 12CYH D 285
TYR D 327
LEU D 330
MET D 364
HIS D 449
PLB  D 701 (-3.2A)
None
PLB  D 701 ( 4.1A)
PLB  D 701 ( 4.8A)
None
0.98Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)		5 / 12GLY D 284
CYH D 285
LEU D 330
MET D 364
HIS D 449
PLB  D 701 (-3.3A)
PLB  D 701 (-3.2A)
PLB  D 701 ( 4.1A)
PLB  D 701 ( 4.8A)
None
1.07Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)		6 / 12GLY D 284
LEU D 330
ILE D 341
MET D 348
MET D 364
HIS D 449
PLB  D 701 (-3.3A)
PLB  D 701 ( 4.1A)
PLB  D 701 (-3.6A)
PLB  D 701 ( 4.7A)
PLB  D 701 ( 4.8A)
None
0.80Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)		8 / 12LEU D 255
PHE D 282
GLY D 284
GLN D 286
LEU D 330
ILE D 341
MET D 348
MET D 364
None
None
PLB  D 701 (-3.3A)
None
PLB  D 701 ( 4.1A)
PLB  D 701 (-3.6A)
PLB  D 701 ( 4.7A)
PLB  D 701 ( 4.8A)
0.52Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)		6 / 12LEU D 255
PHE D 363
LEU D 330
ILE D 341
MET D 348
LEU D 452
None
None
PLB  D 701 ( 4.1A)
PLB  D 701 (-3.6A)
PLB  D 701 ( 4.7A)
None
1.45Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)		6 / 12PHE D 282
GLY D 284
CYH D 285
GLN D 286
LEU D 330
MET D 364
None
PLB  D 701 (-3.3A)
PLB  D 701 (-3.2A)
None
PLB  D 701 ( 4.1A)
PLB  D 701 ( 4.8A)
0.89Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3e9l PRE-MRNA-PROCESSING-
SPLICING FACTOR 8
(Homo
sapiens)		5 / 12LEU A1905
PHE A1818
GLN A1816
LEU A1936
ILE A1967
None
1.12Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		5 / 12LEU A 284
GLY A 324
CYH A 325
GLN A 320
LEU A 308
None
1.28Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens)		5 / 12LEU B 797
GLY B 911
LEU B 866
ILE B 859
LEU B1010
None
1.24Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		4mqj HEMOGLOBIN SUBUNIT
GAMMA-2
(Homo
sapiens)		5 / 12LEU B  81
GLY B  72
LEU B 114
ILE B  11
MET B 133
None
1.25Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		5dsy POLY [ADP-RIBOSE]
POLYMERASE 2
(Homo
sapiens)		5 / 12PHE A 444
GLY A 445
TYR A 460
ILE A 432
LEU A 541
None
None
UHB  A1001 (-3.4A)
None
None
1.01Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		5kre LYSOPHOSPHOLIPASE-LI
KE PROTEIN 1
(Homo
sapiens)		5 / 12LEU A 101
PHE A  26
GLY A 126
LEU A 171
LEU A 218
None
1.23Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		5kre LYSOPHOSPHOLIPASE-LI
KE PROTEIN 1
(Homo
sapiens)		5 / 12LEU A 104
PHE A  26
LEU A 229
ILE A 118
LEU A 218
None
1.25Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		5vni PROTEIN TRANSPORT
PROTEIN SEC23A
(Homo
sapiens)		5 / 12LEU A 426
GLY A 403
GLN A 486
LEU A  45
ILE A 448
None
1.10Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		1imv PIGMENT
EPITHELIUM-DERIVED
FACTOR
(Homo
sapiens)		3 / 3SER A  73
HIS A  99
TYR A 142
None
1.02Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		1kwm PROCARBOXYPEPTIDASE
B
(Homo
sapiens)		3 / 3SER A 131
HIS A 133
TYR A 165
None
1.04Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		1w6j LANOSTEROL SYNTHASE
(Homo
sapiens)		3 / 3SER A 191
HIS A 289
TYR A 297
None
1.02Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		2a1x PHYTANOYL-COA
DIOXYGENASE
(Homo
sapiens)		3 / 3SER A 186
HIS A 259
TYR A  46
None
1.04Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		2hi9 PLASMA SERINE
PROTEASE INHIBITOR
(Homo
sapiens)		3 / 3SER A  61
HIS A  89
TYR A 134
None
1.03Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		2r17 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 35
(Homo
sapiens)		3 / 3SER C 679
HIS C 675
TYR C 729
None
1.01Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		2r55 STAR-RELATED LIPID
TRANSFER PROTEIN 5
(Homo
sapiens)		3 / 3SER A  43
HIS A 177
TYR A  20
None
1.02Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)		3 / 3SER A 289
HIS A 323
TYR A 473
MC5  A   1 (-2.6A)
MC5  A   1 (-3.8A)
MC5  A   1 (-4.9A)
0.34Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3v98 ARACHIDONATE
5-LIPOXYGENASE
(Homo
sapiens)		3 / 3SER A 547
HIS A 399
TYR A 620
None
0.98Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		4c41 CORTICOSTEROID-BINDI
NG GLOBULIN
(Homo
sapiens)		3 / 3SER A  56
HIS A  84
TYR A 129
None
0.97Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		4jgf GAMMA-CRYSTALLIN D
(Homo
sapiens)		3 / 3SER A  20
HIS A  22
TYR A  16
None
0.93Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		4nre ARACHIDONATE
15-LIPOXYGENASE B
(Homo
sapiens)		3 / 3SER A 550
HIS A 405
TYR A 623
None
0.97Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		5ekd TRYPTOPHAN--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens)		3 / 3SER A  72
HIS A 120
TYR A 171
None
0.97Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		5vgz 26S PROTEASOME
REGULATORY SUBUNIT 4
26S PROTEASOME
REGULATORY SUBUNIT 8
(Homo
sapiens;
Homo
sapiens)		3 / 3SER B 108
HIS B 154
TYR C 121
None
0.88Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		2bzl TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 14
(Homo
sapiens)		5 / 12ARG A1157
ILE A1164
ILE A1096
TYR A1092
LEU A1093
None
1.10Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		2jii SERINE/THREONINE-PRO
TEIN KINASE VRK3
MOLECULE: VACCINIA
RELATED KINASE 3
(Homo
sapiens)		5 / 12LEU A 388
PHE A 407
TYR A 446
LEU A 449
HIS A 298
None
EDO  A1474 ( 4.8A)
None
EDO  A1473 (-4.4A)
None
1.10Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens)		7 / 12LEU A 247
ARG A 271
ILE A 272
CYH A 276
GLN A 277
ILE A 317
HIS A 440
None
None
735  A 469 ( 4.2A)
735  A 469 (-2.9A)
735  A 469 (-4.4A)
735  A 469 ( 4.8A)
735  A 469 (-4.0A)
0.98Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens)		7 / 12LEU A 247
ILE A 272
CYH A 276
GLN A 277
ILE A 317
LEU A 321
HIS A 440
None
735  A 469 ( 4.2A)
735  A 469 (-2.9A)
735  A 469 (-4.4A)
735  A 469 ( 4.8A)
735  A 469 ( 4.3A)
735  A 469 (-4.0A)
0.75Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		2ymb MIT
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		5 / 12LEU A 141
PHE A 199
ILE A 151
ILE A 192
ILE A 197
None
1.17Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)		11 / 12LEU A 255
ARG A 280
ILE A 281
CYH A 285
GLN A 286
ILE A 326
TYR A 327
LEU A 330
ILE A 341
MET A 348
HIS A 449
None
None
MC5  A   1 ( 4.8A)
MC5  A   1 (-3.6A)
None
MC5  A   1 ( 4.9A)
None
MC5  A   1 (-4.4A)
MC5  A   1 (-4.5A)
MC5  A   1 ( 4.0A)
MC5  A   1 (-3.9A)
0.61Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)		5 / 12LEU A 255
ILE A 281
GLN A 283
ILE A 341
MET A 348
None
MC5  A   1 ( 4.8A)
None
MC5  A   1 (-4.5A)
MC5  A   1 ( 4.0A)
1.08Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA
(Homo
sapiens)		6 / 12LEU A 255
CYH A 285
GLN A 286
ILE A 326
LEU A 330
HIS A 449
None
L41  A 501 (-3.5A)
None
None
L41  A 501 (-4.9A)
L41  A 501 (-3.9A)
0.75Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)		7 / 12ILE D 281
ILE D 326
TYR D 327
LEU D 330
ILE D 341
MET D 348
HIS D 449
PLB  D 701 (-4.6A)
PLB  D 701 ( 4.5A)
None
PLB  D 701 ( 4.1A)
PLB  D 701 (-3.6A)
PLB  D 701 ( 4.7A)
None
0.76Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)		8 / 12LEU D 255
ARG D 280
ILE D 281
GLN D 286
ILE D 326
LEU D 330
ILE D 341
MET D 348
None
None
PLB  D 701 (-4.6A)
None
PLB  D 701 ( 4.5A)
PLB  D 701 ( 4.1A)
PLB  D 701 (-3.6A)
PLB  D 701 ( 4.7A)
0.67Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)		8 / 12LEU D 255
ARG D 280
ILE D 281
ILE D 326
LEU D 330
ILE D 341
MET D 348
HIS D 449
None
None
PLB  D 701 (-4.6A)
PLB  D 701 ( 4.5A)
PLB  D 701 ( 4.1A)
PLB  D 701 (-3.6A)
PLB  D 701 ( 4.7A)
None
0.76Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3sop NEURONAL-SPECIFIC
SEPTIN-3
(Homo
sapiens)		5 / 12LEU A 300
PHE A 177
ILE A 203
ILE A 146
HIS A 320
None
1.13Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3sop NEURONAL-SPECIFIC
SEPTIN-3
(Homo
sapiens)		5 / 12LEU A 300
PHE A 177
ILE A 203
ILE A 146
TYR A 150
None
1.20Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		4da5 CHOLINE KINASE ALPHA
(Homo
sapiens)		5 / 12PHE A 347
ILE A 228
CYH A 307
GLN A 308
ILE A 343
None
None
None
0H7  A 502 (-3.1A)
None
1.11Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		4ol0 TRANSPORTIN-3
(Homo
sapiens)		5 / 12LEU B  91
ILE B 112
GLN B 118
ILE B 169
LEU B 173
None
1.23Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		5hcc COMPLEMENT C5
COMPLEMENT C5
(Homo
sapiens;
Homo
sapiens)		5 / 12LEU B 575
ILE A 799
ILE B 182
TYR B 146
HIS B 129
None
1.17Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens)		5 / 12PHE A  99
GLN A 104
ILE A 154
TYR A 142
ILE A  78
None
0.83Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		1bhg BETA-GLUCURONIDASE
(Homo
sapiens)		4 / 8GLU A 544
PHE A 206
HIS A 127
LEU A 176
None
1.11Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		2q6z UROPORPHYRINOGEN
DECARBOXYLASE
(Homo
sapiens)		4 / 8GLU A 278
PHE A 154
SER A 219
MET A  36
None
1.08Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)		5 / 8GLU A 259
PHE A 282
PHE A 363
MET A 364
LEU A 453
None
MC5  A   1 (-4.4A)
None
MC5  A   1 (-3.7A)
MC5  A   1 (-4.2A)
1.00Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)		5 / 8GLU A 259
PHE A 282
SER A 289
HIS A 323
MET A 364
None
MC5  A   1 (-4.4A)
MC5  A   1 (-2.6A)
MC5  A   1 (-3.8A)
MC5  A   1 (-3.7A)
0.79Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)		5 / 8GLU A 259
PHE A 282
SER A 289
MET A 364
LEU A 453
None
MC5  A   1 (-4.4A)
MC5  A   1 (-2.6A)
MC5  A   1 (-3.7A)
MC5  A   1 (-4.2A)
0.89Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3keh GLUCOCEREBROSIDASE
(Homo
sapiens)		4 / 8GLU A 340
HIS A 223
PHE A 216
LEU A 149
None
1.10Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3q2h A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 1
(Homo
sapiens)		4 / 8HIS A 153
PHE A 155
SER A 132
LEU A 211
QHF  A   1 ( 3.0A)
None
None
None
1.06Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens)		4 / 8GLU A  88
PHE A 302
SER A 219
PHE A 303
None
1.10Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens)		4 / 8GLU B  88
PHE B 302
SER B 219
PHE B 303
None
1.09Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens)		4 / 8HIS A 365
PHE A 367
SER A 344
LEU A 424
 ZN  A 501 ( 3.3A)
None
None
None
1.11Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		5bug PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
3-PHOSPHATASE AND
DUAL-SPECIFICITY
PROTEIN PHOSPHATASE
PTEN
(Homo
sapiens)		4 / 8GLU A 284
PHE A 279
PHE A 278
LEU A  98
None
1.05Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Homo
sapiens)		4 / 8HIS A  20
PHE A  69
PHE A  42
LEU A 348
HIS  A  20 ( 1.0A)
PHE  A  69 ( 1.3A)
PHE  A  42 ( 1.3A)
LEU  A 348 ( 0.6A)
1.11Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		5fu7 CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
(Homo
sapiens)		4 / 8HIS A2024
PHE A2023
PHE A2047
MET A2051
None
1.11Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		5fu7 CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
(Homo
sapiens)		4 / 8HIS A2282
PHE A2284
HIS A2114
LEU A2220
None
1.03Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		5gs0 TOLL-LIKE RECEPTOR 3
(Homo
sapiens)		4 / 8SER A 389
PHE A 375
MET A 374
LEU A 412
None
1.06Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens)		4 / 8GLU A2344
HIS A2689
PHE A2682
LEU A2632
 MG  A4803 ( 3.1A)
None
None
None
1.02Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6ez8 HUNTINGTIN
(Homo
sapiens)		4 / 8HIS A 722
PHE A 727
SER A 779
LEU A 800
None
1.07Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		1ek6 UDP-GALACTOSE
4-EPIMERASE
(Homo
sapiens)		5 / 12ILE A 113
GLY A 111
LEU A 127
ILE A 164
MET A 167
None
1.04A21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		1xwi SKD1 PROTEIN
(Homo
sapiens)		5 / 12LEU A 146
ILE A 170
GLY A 276
ILE A 230
LEU A 239
None
0.96A24.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens)		5 / 12LEU A 247
ILE A 272
LEU A 321
MET A 355
LEU A 460
None
735  A 469 ( 4.2A)
735  A 469 ( 4.3A)
735  A 469 (-2.9A)
735  A 469 (-4.3A)
0.62A61.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		2vt8 PROTEASOME INHIBITOR
PI31 SUBUNIT
(Homo
sapiens)		5 / 12LEU A 106
ARG A 133
ILE A 134
GLY A 137
LEU A  78
None
0.81A19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		2vt8 PROTEASOME INHIBITOR
PI31 SUBUNIT
(Homo
sapiens)		5 / 12LEU A 106
ARG A 133
ILE A 134
GLY A 137
VAL A  80
None
0.69A19.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)		12 / 12LEU A 255
ARG A 280
ILE A 281
GLY A 284
TYR A 327
LEU A 330
VAL A 339
ILE A 341
MET A 348
MET A 364
LEU A 453
LEU A 469
None
None
MC5  A   1 ( 4.8A)
MC5  A   1 ( 4.5A)
None
MC5  A   1 (-4.4A)
MC5  A   1 (-4.6A)
MC5  A   1 (-4.5A)
MC5  A   1 ( 4.0A)
MC5  A   1 (-3.7A)
MC5  A   1 (-4.2A)
MC5  A   1 (-4.1A)
0.57A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)		5 / 12LEU A 255
ILE A 281
ILE A 341
MET A 348
LEU A 465
None
MC5  A   1 ( 4.8A)
MC5  A   1 (-4.5A)
MC5  A   1 ( 4.0A)
None
1.04A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)		10 / 12LEU D 255
ARG D 280
ILE D 281
GLY D 284
LEU D 330
VAL D 339
ILE D 341
MET D 348
MET D 364
LEU D 469
None
None
PLB  D 701 (-4.6A)
PLB  D 701 (-3.3A)
PLB  D 701 ( 4.1A)
None
PLB  D 701 (-3.6A)
PLB  D 701 ( 4.7A)
PLB  D 701 ( 4.8A)
None
0.56A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)		7 / 12LEU D 255
ARG D 280
ILE D 281
LEU D 330
VAL D 339
MET D 348
LEU D 469
None
None
PLB  D 701 (-4.6A)
PLB  D 701 ( 4.1A)
None
PLB  D 701 ( 4.7A)
None
1.46A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)		6 / 12LEU D 255
ILE D 281
VAL D 339
ILE D 341
MET D 348
LEU D 465
None
PLB  D 701 (-4.6A)
None
PLB  D 701 (-3.6A)
PLB  D 701 ( 4.7A)
None
1.09A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)		7 / 12TYR D 327
LEU D 330
VAL D 339
ILE D 341
MET D 348
MET D 364
LEU D 469
None
PLB  D 701 ( 4.1A)
None
PLB  D 701 (-3.6A)
PLB  D 701 ( 4.7A)
PLB  D 701 ( 4.8A)
None
0.75A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		4m6w FANCONI ANEMIA GROUP
M PROTEIN
(Homo
sapiens)		5 / 12GLY A1823
LEU A1945
VAL A1833
ILE A1834
LEU A1887
SO4  A2101 (-3.5A)
None
None
None
None
0.94A20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		5va3 POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 2
(Homo
sapiens)		5 / 12LEU A 622
ILE A 560
ILE A 655
MET A 651
LEU A 415
None
1.01A17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		5wbg CYTOCHROME P450 2B6
(Homo
sapiens)		5 / 12LEU A 437
GLY A 299
ILE A 441
MET A 132
LEU A 199
HEM  A 501 (-4.7A)
HEM  A 501 ( 3.9A)
HEM  A 501 ( 4.5A)
HEM  A 501 ( 4.7A)
None
0.94Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		6b74 COAGULATION FACTOR
XII
(Homo
sapiens)		6 / 12LEU B 155
ILE B  30
GLY B 197
LEU B 106
VAL B  66
LEU B 123
None
1.35Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens)		4 / 6CYH A1316
HIS A1350
HIS A1313
TYR A1262
None
1.50A19.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YCN_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens)		4 / 6CYH A 276
SER A 280
HIS A 440
TYR A 464
735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 (-4.0A)
735  A 469 (-4.6A)
0.68A61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YCN_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens)		4 / 6PHE A 273
CYH A 276
SER A 280
TYR A 464
735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 (-4.6A)
0.52A61.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		2x25 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
A
(Homo
sapiens)		4 / 6PHE B  60
CYH B 115
SER B  99
HIS B 126
None
None
None
ALY  B 125 ( 3.6A)
1.47A19.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YCN_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)		6 / 6PHE A 282
CYH A 285
SER A 289
HIS A 323
HIS A 449
TYR A 473
MC5  A   1 (-4.4A)
MC5  A   1 (-3.6A)
MC5  A   1 (-2.6A)
MC5  A   1 (-3.8A)
MC5  A   1 (-3.9A)
MC5  A   1 (-4.9A)
0.39A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YCN_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA
(Homo
sapiens)		4 / 6CYH A 285
HIS A 323
HIS A 449
TYR A 473
L41  A 501 (-3.5A)
L41  A 501 (-3.8A)
L41  A 501 (-3.9A)
L41  A 501 (-4.8A)
0.60A62.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YCN_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA
(Homo
sapiens)		4 / 6PHE A 282
CYH A 285
HIS A 323
TYR A 473
L41  A 501 ( 4.9A)
L41  A 501 (-3.5A)
L41  A 501 (-3.8A)
L41  A 501 (-4.8A)
0.64A62.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3dls PAS
DOMAIN-CONTAINING
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens)		4 / 6PHE A1162
CYH A1163
SER A1149
HIS A1126
None
1.47A20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		5hcc COMPLEMENT C5
(Homo
sapiens)		4 / 6SER A1007
HIS A1421
HIS A1499
TYR A1124
None
1.46A14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		5l7k PROTEIN UNC-119
HOMOLOG A
(Homo
sapiens)		4 / 6PHE A  91
SER A 218
HIS A 165
TYR A 194
None
1.17A22.06