POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UIH_A_8CVA201_1 (DIHYDROFOLATE REDUCTASE)	1t3g	X-LINKED INTERLEUKIN-1 RECEPTOR ACCESSORY PROTEIN-LIKE 1 (Homo sapiens)	4 / 8	ILE A 510 LEU A 431 ILE A 474 THR A 478	None	0.84A	20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UIH_A_8CVA201_1 (DIHYDROFOLATE REDUCTASE)	1u71	DIHYDROFOLATE REDUCTASE (Homo sapiens)	4 / 8	ILE A   7 ALA A   9 TYR A 121 THR A 136	MXA  A 187 (-4.5A) MXA  A 187 (-3.6A) None MXA  A 187 (-4.3A)	0.30A	27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UIH_A_8CVA201_1 (DIHYDROFOLATE REDUCTASE)	1wb0	CHITOTRIOSIDASE 1 (Homo sapiens)	4 / 8	ALA A 183 ASP A 136 LEU A  93 TYR A 212	None	0.87A	10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UIH_A_8CVA201_1 (DIHYDROFOLATE REDUCTASE)	3lmk	METABOTROPIC GLUTAMATE RECEPTOR 5 (Homo sapiens)	4 / 8	ILE A  37 ALA A  39 LEU A  73 ILE A  36	None	0.77A	10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UIH_A_8CVA201_1 (DIHYDROFOLATE REDUCTASE)	3sob	LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6 (Homo sapiens)	4 / 8	ALA B 101 MET B 152 LEU B 187 ILE B 119	None	0.90A	12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UIH_A_8CVA201_1 (DIHYDROFOLATE REDUCTASE)	3zcw	KINESIN-LIKE PROTEIN KIF11 (Homo sapiens)	4 / 8	ILE A  19 LEU A 320 ILE A 332 THR A 328	None None 4A2  A1366 (-3.9A) None	0.66A	12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UIH_A_8CVA201_1 (DIHYDROFOLATE REDUCTASE)	4fdj	N-ACETYLGALACTOSAMIN E-6-SULFATASE (Homo sapiens)	4 / 8	ILE A 265 MET A  41 LEU A  37 ILE A 261	None	0.90A	10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UIH_A_8CVA201_1 (DIHYDROFOLATE REDUCTASE)	4flc	ADENYLOSUCCINATE LYASE (Homo sapiens)	4 / 8	ILE A 237 ALA A 235 ASP A 223 ILE A 238	None	0.85A	11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UIH_A_8CVA201_1 (DIHYDROFOLATE REDUCTASE)	4z3k	SEPIAPTERIN REDUCTASE (Homo sapiens)	4 / 8	ILE A  95 LEU A 241 ILE A 152 THR A 148	None None NAP  A 801 (-4.5A) None	0.64A	15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UIH_A_8CVA201_1 (DIHYDROFOLATE REDUCTASE)	5xtb	NADH-UBIQUINONE OXIDOREDUCTASE 75 KDA SUBUNIT, MITOCHONDRIAL (Homo sapiens)	4 / 8	ILE M 455 ALA M 492 LEU M 476 ILE M 451	None	0.76A	9.00