POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_1
(DIPEPTIDYL PEPTIDASE
IV)		1szb MANNOSE BINDING
LECTIN-ASSOCIATED
SERINE PROTEASE-2
RELATED PROTEIN,
MAP19 (19KDA)
(Homo
sapiens)		5 / 12GLU A  52
SER A  54
PHE A  61
TYR A  24
ASN A 108
GLU  A  52 (-0.6A)
SER  A  54 ( 0.0A)
PHE  A  61 ( 1.3A)
TYR  A  24 ( 1.3A)
ASN  A 108 (-0.6A)
1.05A11.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1X70_A_715A801_1
(DIPEPTIDYL PEPTIDASE
IV)		1z68 FIBROBLAST
ACTIVATION PROTEIN,
ALPHA SUBUNIT
(Homo
sapiens)		10 / 12ARG A 123
GLU A 203
GLU A 204
TYR A 541
VAL A 650
TYR A 656
TYR A 660
ASN A 704
VAL A 705
HIS A 734
None
0.54A53.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1X70_A_715A801_1
(DIPEPTIDYL PEPTIDASE
IV)		1z68 FIBROBLAST
ACTIVATION PROTEIN,
ALPHA SUBUNIT
(Homo
sapiens)		7 / 12ARG A 123
GLU A 204
PHE A 351
TYR A 656
ASN A 704
VAL A 705
HIS A 734
None
1.46A53.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1X70_A_715A801_1
(DIPEPTIDYL PEPTIDASE
IV)		1z68 FIBROBLAST
ACTIVATION PROTEIN,
ALPHA SUBUNIT
(Homo
sapiens)		6 / 12ARG A 123
PHE A 350
TYR A 541
VAL A 650
TYR A 660
HIS A 734
None
1.03A53.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_1
(DIPEPTIDYL PEPTIDASE
IV)		2g1l KINESIN-LIKE PROTEIN
KIF1C
(Homo
sapiens)		5 / 12GLU A 512
SER A 511
VAL A 588
ASN A 505
VAL A 594
None
1.48A9.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1X70_A_715A801_1
(DIPEPTIDYL PEPTIDASE
IV)		2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens)		12 / 12ARG A 125
GLU A 205
GLU A 206
SER A 209
PHE A 357
TYR A 547
VAL A 656
TYR A 662
TYR A 666
ASN A 710
VAL A 711
HIS A 740
ACF  A 800 (-3.4A)
ACF  A 800 (-3.6A)
ACF  A 800 (-3.2A)
None
None
ACF  A 800 (-4.5A)
None
ACF  A 800 (-4.1A)
ACF  A 800 (-3.3A)
ACF  A 800 (-3.3A)
None
None
0.26A99.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_1
(DIPEPTIDYL PEPTIDASE
IV)		3rze HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens)		5 / 12PHE A 435
VAL A  76
TYR A 458
ASN A  84
VAL A  80
D7V  A1201 ( 3.8A)
None
5EH  A1200 ( 4.4A)
None
None
1.43A20.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1X70_A_715A801_1
(DIPEPTIDYL PEPTIDASE
IV)		4wjl INACTIVE DIPEPTIDYL
PEPTIDASE 10
(Homo
sapiens)		5 / 12GLU A 233
GLU A 234
TYR A 683
VAL A 730
HIS A 759
None
0.75A36.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_1
(DIPEPTIDYL PEPTIDASE
IV)		6b9m E3 UBIQUITIN-PROTEIN
LIGASE UHRF1
(Danio
rerio;
Homo
sapiens)		5 / 12ARG D 649
GLU A 155
SER D 651
TYR A 180
VAL A 143
None
1.23A5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_1
(DIPEPTIDYL PEPTIDASE
IV)		6eoq DIPEPTIDYL PEPTIDASE
9
(Homo
sapiens)		8 / 12GLU A 249
TYR A 644
VAL A 756
TYR A 762
TYR A 766
ASN A 810
VAL A 811
HIS A 840
None
0.52A6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_1
(DIPEPTIDYL PEPTIDASE
IV)		6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens)		10 / 12ARG A 160
GLU A 275
GLU A 276
TYR A 669
VAL A 781
TYR A 787
TYR A 791
ASN A 835
VAL A 836
HIS A 865
None
0.63A7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		1q33 ADP-RIBOSE
PYROPHOSPHATASE
(Homo
sapiens)		3 / 3ARG A 148
SER A  68
TYR A  70
None
0.67A20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		2c60 HUMAN
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 3
ISOFORM 2
(Homo
sapiens)		3 / 3ARG A  56
SER A  91
TYR A  85
None
0.77A9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		2cq1 PTB-LIKE PROTEIN L
(Homo
sapiens)		3 / 3ARG A  59
SER A 115
TYR A 114
None
0.60A10.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens)		3 / 3ARG A 358
SER A 630
TYR A 631
None
ACF  A 800 (-1.3A)
None
0.76A99.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		2n1k FIBRONECTIN
(Homo
sapiens)		3 / 3ARG A  29
SER A  88
TYR A  80
None
0.67A9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens)		3 / 3ARG A 256
SER A 373
TYR A 371
DTP  A1745 (-3.0A)
None
None
0.58A21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens)		3 / 3ARG A 430
SER A 381
TYR A 380
None
0.51A16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		3swv BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 2
(Homo
sapiens)		3 / 3ARG A 752
SER A 775
TYR A 774
None
0.69A14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		3t0o RIBONUCLEASE T2
(Homo
sapiens)		3 / 3ARG A  94
SER A 130
TYR A 134
None
0.71A14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		4bvx EUKARYOTIC
TRANSLATION
ELONGATION FACTOR 1
EPSILON-1
METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens)		3 / 3ARG A   2
SER B 100
TYR B 101
I3C  A1204 (-3.1A)
None
None
0.61A13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		4da5 CHOLINE KINASE ALPHA
(Homo
sapiens)		3 / 3ARG A 367
SER A 355
TYR A 354
None
None
0H7  A 502 (-3.5A)
0.60A19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens)		3 / 3ARG A 466
SER A 521
TYR A 520
None
0.74A21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		4or2 SOLUBLE CYTOCHROME
B562, METABOTROPIC
GLUTAMATE RECEPTOR 1
(Escherichia
coli;
Homo
sapiens)		3 / 3ARG A 661
SER A 673
TYR A 672
None
0.70A19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		4s0h T-BOX TRANSCRIPTION
FACTOR TBX5
(Homo
sapiens)		3 / 3ARG A 134
SER A  86
TYR A  87
None
0.73A14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		4zdh BETA CHAIN OF JKF6
T-CELL
RECEPTOR,PROTEIN
TRBV28
(Homo
sapiens)		3 / 3ARG B  14
SER B  65
TYR B  64
None
0.75A16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens)		3 / 3ARG A 831
SER A 899
TYR A 900
None
0.67A19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens)		3 / 3ARG A 256
SER A 373
TYR A 371
TTP  A1601 (-3.2A)
None
None
0.68A21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens)		3 / 3ARG A  71
SER A 112
TYR A 111
None
0.77A17.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1X70_B_715B801_1
(DIPEPTIDYL PEPTIDASE
IV)		1z68 FIBROBLAST
ACTIVATION PROTEIN,
ALPHA SUBUNIT
(Homo
sapiens)		10 / 12ARG A 123
GLU A 203
GLU A 204
SER A 624
VAL A 650
TYR A 656
TYR A 660
ASN A 704
VAL A 705
HIS A 734
None
0.56A53.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_1
(DIPEPTIDYL PEPTIDASE
IV)		2g1l KINESIN-LIKE PROTEIN
KIF1C
(Homo
sapiens)		5 / 12GLU A 512
SER A 511
VAL A 588
ASN A 505
VAL A 594
None
1.49A9.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1X70_B_715B801_1
(DIPEPTIDYL PEPTIDASE
IV)		2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens)		12 / 12ARG A 125
GLU A 205
GLU A 206
SER A 209
ARG A 358
SER A 630
VAL A 656
TYR A 662
TYR A 666
ASN A 710
VAL A 711
HIS A 740
ACF  A 800 (-3.4A)
ACF  A 800 (-3.6A)
ACF  A 800 (-3.2A)
None
None
ACF  A 800 (-1.3A)
None
ACF  A 800 (-4.1A)
ACF  A 800 (-3.3A)
ACF  A 800 (-3.3A)
None
None
0.32A99.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_1
(DIPEPTIDYL PEPTIDASE
IV)		3ddu PROLYL ENDOPEPTIDASE
(Homo
sapiens)		5 / 12ARG A 252
SER A 554
VAL A 580
VAL A 644
HIS A 680
None
ACT  A 801 ( 2.6A)
None
None
ACT  A 801 (-3.8A)
1.14A22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_1
(DIPEPTIDYL PEPTIDASE
IV)		3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens)		5 / 12GLU A 327
ARG A 325
SER A 242
VAL A 252
TYR A 370
None
1.44A21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_1
(DIPEPTIDYL PEPTIDASE
IV)		4o7d GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens)		5 / 12GLU A 381
SER A 384
SER A 286
VAL A 288
TYR A 414
ONL  A 601 (-2.8A)
None
ONL  A 601 (-1.4A)
None
ONL  A 601 (-4.7A)
1.28A17.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1X70_B_715B801_1
(DIPEPTIDYL PEPTIDASE
IV)		4wjl INACTIVE DIPEPTIDYL
PEPTIDASE 10
(Homo
sapiens)		5 / 12GLU A 233
GLU A 234
TYR A 683
VAL A 730
HIS A 759
None
0.75A36.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_1
(DIPEPTIDYL PEPTIDASE
IV)		5d3o GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens)		5 / 12GLU A 386
SER A 389
SER A 291
VAL A 293
TYR A 419
None
1.22A20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_1
(DIPEPTIDYL PEPTIDASE
IV)		5gwn PROTEIN RCC2
(Homo
sapiens)		5 / 12SER A 417
SER A 353
VAL A 351
VAL A 376
HIS A 364
None
1.06A20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_1
(DIPEPTIDYL PEPTIDASE
IV)		6b9m E3 UBIQUITIN-PROTEIN
LIGASE UHRF1
(Danio
rerio;
Homo
sapiens)		5 / 12ARG D 649
GLU A 155
SER D 651
TYR A 180
VAL A 143
None
1.24A5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_1
(DIPEPTIDYL PEPTIDASE
IV)		6eoq DIPEPTIDYL PEPTIDASE
9
(Homo
sapiens)		8 / 12GLU A 249
SER A 730
VAL A 756
TYR A 762
TYR A 766
ASN A 810
VAL A 811
HIS A 840
None
0.53A6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_1
(DIPEPTIDYL PEPTIDASE
IV)		6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens)		10 / 12ARG A 160
GLU A 275
GLU A 276
SER A 755
VAL A 781
TYR A 787
TYR A 791
ASN A 835
VAL A 836
HIS A 865
None
0.62A7.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens)		3 / 3PHE A 357
TYR A 547
TYR A 631
None
ACF  A 800 (-4.5A)
None
0.18A99.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		2w9f CELL DIVISION
PROTEIN KINASE 4
(Homo
sapiens)		3 / 3PHE B  93
TYR B 165
TYR B  17
None
0.93A18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		3pg7 NEUROFIBROMIN
(Homo
sapiens)		3 / 3PHE A1572
TYR A1618
TYR A1614
PTY  A 400 (-4.6A)
None
None
0.95A17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		4k0v TEK TYROSINE KINASE
VARIANT
(Homo
sapiens)		3 / 3PHE A 536
TYR A 513
TYR A 483
None
1.08A20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		4l9c F-BOX ONLY PROTEIN 7
(Homo
sapiens)		3 / 3PHE A 308
TYR A 238
TYR A 212
None
1.00A12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		4nky STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE
(Homo
sapiens)		3 / 3PHE A  42
TYR A  64
TYR A  60
None
1.04A21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		4ny4 CYTOCHROME P450 3A4
(Homo
sapiens)		3 / 3PHE A 447
TYR A 179
TYR A 152
None
1.04A21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		5l7k PROTEIN UNC-119
HOMOLOG A
(Homo
sapiens)		3 / 3PHE A 196
TYR A 236
TYR A 234
None
0.95A13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		5tj7 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2
(Homo
sapiens)		3 / 3PHE A 621
TYR A 499
TYR A 392
None
0.94A20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		5veu CYTOCHROME P450 3A5
(Homo
sapiens)		3 / 3PHE A 446
TYR A 179
TYR A 152
HEM  A 601 ( 4.9A)
None
None
0.70A21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		5wy0 SMALL RNA
2'-O-METHYLTRANSFERA
SE
(Homo
sapiens)		3 / 3PHE A  95
TYR A  81
TYR A 220
None
0.93A8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		5zal ENDORIBONUCLEASE
DICER
(Homo
sapiens)		3 / 3PHE A1666
TYR A1692
TYR A1694
None
0.90A8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		6ces RAS-RELATED
GTP-BINDING PROTEIN
A
(Homo
sapiens)		3 / 3PHE A  74
TYR A  90
TYR A 106
None
1.03A6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		1uou THYMIDINE
PHOSPHORYLASE
(Homo
sapiens)		5 / 12ARG A  48
GLU A  87
GLY A  47
ARG A  81
VAL A 258
None
1.29A20.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		1z68 FIBROBLAST
ACTIVATION PROTEIN,
ALPHA SUBUNIT
(Homo
sapiens)		10 / 12ARG A 123
GLU A 203
GLU A 204
TYR A 541
SER A 624
VAL A 650
TYR A 656
ASN A 704
VAL A 705
HIS A 734
None
0.50A54.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens)		11 / 12ARG A 125
GLU A 205
GLU A 206
ARG A 358
TYR A 547
SER A 630
VAL A 656
TYR A 662
ASN A 710
VAL A 711
HIS A 740
ACF  A 800 (-3.4A)
ACF  A 800 (-3.6A)
ACF  A 800 (-3.2A)
None
ACF  A 800 (-4.5A)
ACF  A 800 (-1.3A)
None
ACF  A 800 (-4.1A)
ACF  A 800 (-3.3A)
None
None
0.36A84.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		2yd3 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens)		5 / 12GLY A 203
TYR A 217
SER A  51
VAL A  53
VAL A  90
None
None
None
NA  A1229 (-4.5A)
None
1.19A14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		3ddu PROLYL ENDOPEPTIDASE
(Homo
sapiens)		6 / 12ARG A 252
TYR A 473
SER A 554
VAL A 580
VAL A 644
HIS A 680
None
ACT  A 801 (-4.5A)
ACT  A 801 ( 2.6A)
None
None
ACT  A 801 (-3.8A)
1.00A21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		3i6u SERINE/THREONINE-PRO
TEIN KINASE CHK2
(Homo
sapiens)		5 / 12GLU A 219
VAL A 246
TYR A 220
ASN A 290
VAL A 300
None
1.17A21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		4pbx RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens)		5 / 12GLY A 203
TYR A 217
SER A  51
VAL A  53
VAL A  90
None
1.17A21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		4w82 FATTY ACID SYNTHASE
(Homo
sapiens)		5 / 12GLU A1768
SER A1756
ASN A1746
VAL A1744
HIS A1674
None
1.43A18.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		4wjl INACTIVE DIPEPTIDYL
PEPTIDASE 10
(Homo
sapiens)		5 / 12GLU A 233
GLU A 234
TYR A 683
VAL A 730
HIS A 759
None
0.72A38.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		6eoq DIPEPTIDYL PEPTIDASE
9
(Homo
sapiens)		5 / 12GLU A 249
TYR A 644
SER A 730
TYR A 762
VAL A 811
None
1.11A7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		6eoq DIPEPTIDYL PEPTIDASE
9
(Homo
sapiens)		8 / 12GLU A 249
TYR A 644
SER A 730
VAL A 756
TYR A 762
ASN A 810
VAL A 811
HIS A 840
None
0.60A7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens)		10 / 12ARG A 160
GLU A 275
GLU A 276
TYR A 669
SER A 755
VAL A 781
TYR A 787
ASN A 835
VAL A 836
HIS A 865
None
0.71A8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens)		5 / 12GLU A 275
TYR A 669
SER A 755
VAL A 781
TYR A 787
None
1.16A8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		1g55 DNA CYTOSINE
METHYLTRANSFERASE
DNMT2
(Homo
sapiens)		3 / 3PHE A 293
TYR A 342
TYR A 370
None
1.05A20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		1h2t 80 KDA NUCLEAR CAP
BINDING PROTEIN
(Homo
sapiens)		3 / 3PHE C 271
TYR C 121
TYR C 169
None
0.86A22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens)		3 / 3PHE A 529
TYR A 486
TYR A 523
None
1.10A17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		1qgr PROTEIN (IMPORTIN
BETA SUBUNIT)
(Homo
sapiens)		3 / 3PHE A 503
TYR A 482
TYR A 497
None
1.10A21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		1tki TITIN
(Homo
sapiens)		3 / 3PHE A 114
TYR A 124
TYR A 152
None
0.75A16.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens)		3 / 3PHE A 357
TYR A 631
TYR A 666
None
None
ACF  A 800 (-3.3A)
0.26A84.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens)		3 / 3PHE U 141
TYR U  67
TYR U  34
None
1.05A16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens)		3 / 3PHE A 367
TYR A 294
TYR A 304
None
1.09A18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		3hd6 AMMONIUM TRANSPORTER
RH TYPE C
(Homo
sapiens)		3 / 3PHE A 139
TYR A 435
TYR A  84
None
1.04A20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		3ol2 SEMAPHORIN-4D
(Homo
sapiens)		3 / 3PHE A  71
TYR A  48
TYR A  50
None
NAG  A1000 ( 4.6A)
None
1.04A20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN
(Homo
sapiens)		3 / 3PHE H 529
TYR H 486
TYR H 523
None
1.00A15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		4gul PIRIN
(Homo
sapiens)		3 / 3PHE A  42
TYR A  66
TYR A 171
None
1.04A17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		4nux INTERLEUKIN-17
RECEPTOR A
(Homo
sapiens)		3 / 3PHE A 504
TYR A 384
TYR A 391
None
1.06A13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		4z2a FURIN
(Homo
sapiens)		3 / 3PHE A 275
TYR A 571
TYR A 313
None
1.08A20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		4ztd PROLIFERATING CELL
NUCLEAR ANTIGEN
(Homo
sapiens)		3 / 3PHE A 144
TYR A 249
TYR A 239
None
1.02A16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		5mr5 GDNF FAMILY RECEPTOR
ALPHA-2
(Homo
sapiens)		3 / 3PHE C 208
TYR C 309
TYR C 297
None
1.08A7.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		1z68 FIBROBLAST
ACTIVATION PROTEIN,
ALPHA SUBUNIT
(Homo
sapiens)		10 / 12ARG A 123
GLU A 203
GLU A 204
TYR A 541
SER A 624
VAL A 650
TYR A 656
TYR A 660
VAL A 705
HIS A 734
None
0.58A54.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		1z68 FIBROBLAST
ACTIVATION PROTEIN,
ALPHA SUBUNIT
(Homo
sapiens)		7 / 12ARG A 123
PHE A 350
TYR A 541
SER A 624
VAL A 650
TYR A 660
HIS A 734
None
1.11A54.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		2bk8 TITIN HEART ISOFORM
N2-B
(Homo
sapiens)		5 / 12ARG A  95
GLU A  88
VAL A  18
TYR A  20
TYR A  72
None
1.43A9.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens)		11 / 12ARG A 125
GLU A 205
GLU A 206
PHE A 357
TYR A 547
SER A 630
VAL A 656
TYR A 662
TYR A 666
VAL A 711
HIS A 740
ACF  A 800 (-3.4A)
ACF  A 800 (-3.6A)
ACF  A 800 (-3.2A)
None
ACF  A 800 (-4.5A)
ACF  A 800 (-1.3A)
None
ACF  A 800 (-4.1A)
ACF  A 800 (-3.3A)
None
None
0.39A84.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens)		7 / 12GLU A 205
PHE A 357
TYR A 547
SER A 630
VAL A 656
TYR A 662
VAL A 711
ACF  A 800 (-3.6A)
None
ACF  A 800 (-4.5A)
ACF  A 800 (-1.3A)
None
ACF  A 800 (-4.1A)
None
1.29A84.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		2yd3 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens)		5 / 12GLY A 203
TYR A 217
SER A  51
VAL A  53
VAL A  90
None
None
None
NA  A1229 (-4.5A)
None
1.19A14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		3ddu PROLYL ENDOPEPTIDASE
(Homo
sapiens)		5 / 12GLY A 254
TYR A 473
SER A 554
TYR A 599
VAL A 644
552  A 901 (-4.4A)
ACT  A 801 (-4.5A)
ACT  A 801 ( 2.6A)
None
None
0.98A21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		3ddu PROLYL ENDOPEPTIDASE
(Homo
sapiens)		5 / 12TYR A 473
SER A 554
VAL A 580
VAL A 644
HIS A 680
ACT  A 801 (-4.5A)
ACT  A 801 ( 2.6A)
None
None
ACT  A 801 (-3.8A)
0.31A21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		4ldq METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Homo
sapiens)		5 / 12GLU A 219
GLY A 171
PHE A 214
TYR A  27
TYR A 218
None
1.32A19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		4nfn TAU-TUBULIN KINASE 1
(Homo
sapiens)		5 / 12ARG A 119
GLU A 231
PHE A 126
SER A 158
TYR A 205
SO4  A 403 (-4.6A)
SO4  A 403 ( 4.9A)
None
2KC  A 401 ( 3.1A)
None
1.30A17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		4pbx RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens)		5 / 12GLY A 203
TYR A 217
SER A  51
VAL A  53
VAL A  90
None
1.17A21.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		4wjl INACTIVE DIPEPTIDYL
PEPTIDASE 10
(Homo
sapiens)		5 / 12GLU A 233
GLU A 234
TYR A 683
VAL A 730
HIS A 759
None
0.63A38.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		6eoq DIPEPTIDYL PEPTIDASE
9
(Homo
sapiens)		8 / 12GLU A 249
TYR A 644
SER A 730
VAL A 756
TYR A 762
TYR A 766
VAL A 811
HIS A 840
None
0.56A7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens)		10 / 12ARG A 160
GLU A 275
GLU A 276
TYR A 669
SER A 755
VAL A 781
TYR A 787
TYR A 791
VAL A 836
HIS A 865
None
0.56A8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens)		5 / 12GLU A 275
TYR A 669
SER A 755
VAL A 781
TYR A 787
None
1.11A8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		1d7w MYELOPEROXIDASE
(Homo
sapiens)		3 / 3ARG C 403
TYR C 334
ASN C 330
None
HEM  A 605 ( 4.8A)
None
0.87A20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		1lar PROTEIN (LAR)
(Homo
sapiens)		3 / 3ARG A1354
TYR A1361
ASN A1345
None
0.82A21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		1w6j LANOSTEROL SYNTHASE
(Homo
sapiens)		3 / 3ARG A 435
TYR A 528
ASN A 495
None
0.88A23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		2bzl TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 14
(Homo
sapiens)		3 / 3ARG A1154
TYR A 979
ASN A 948
None
0.88A16.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens)		3 / 3ARG A 358
TYR A 631
ASN A 710
None
None
ACF  A 800 (-3.3A)
0.48A84.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		2jgz CELL DIVISION
PROTEIN KINASE 2
G2/MITOTIC-SPECIFIC
CYCLIN-B1
(Homo
sapiens)		3 / 3ARG B 308
TYR A 179
ASN A 272
None
0.91A15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		3ctt MALTASE-GLUCOAMYLASE
(Homo
sapiens)		3 / 3ARG A 471
TYR A 214
ASN A 498
None
0.73A22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B
(Homo
sapiens)		3 / 3ARG A 925
TYR A 630
ASN A 633
None
0.56A21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		3wih ANTI-HUMAN ROBO1
ANTIBODY B2212A FAB
HEAVY CHAIN
ROUNDABOUT HOMOLOG 1
(Homo
sapiens;
Mus
musculus)		3 / 3ARG A  50
TYR H  32
ASN H  35
None
0.86A10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		4a0l CULLIN-4B
(Homo
sapiens)		3 / 3ARG E 889
TYR E 598
ASN E 557
None
0.84A22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens)		3 / 3ARG A1421
TYR A1428
ASN A1412
None
0.82A20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		4hq6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens)		3 / 3ARG A 281
TYR A 683
ASN A 673
None
0.95A22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		5epz ANGIOGENIN
(Homo
sapiens)		3 / 3ARG A   5
TYR A  14
ASN A  43
None
0.89A10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		5h08 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA
(Homo
sapiens)		3 / 3ARG A1755
TYR A1762
ASN A1746
None
0.75A17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		5mfa MYELOPEROXIDASE
(Homo
sapiens)		3 / 3ARG A 569
TYR A 500
ASN A 496
None
HEM  A 812 ( 4.3A)
None
0.86A23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		5vni PROTEIN TRANSPORT
PROTEIN SEC24A
(Homo
sapiens)		3 / 3ARG B 750
TYR B 456
ASN B 459
None
0.71A21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		5xez GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Escherichia
virus
T4;
Homo
sapiens)		3 / 3ARG A 413
TYR A 343
ASN A 174
None
0.87A20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		6azp MYELOPEROXIDASE
(Homo
sapiens)		3 / 3ARG A 569
TYR A 500
ASN A 496
None
0.84A6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		6bli CB002.5 FAB HEAVY
CHAIN
(Homo
sapiens)		3 / 3ARG A 100
TYR A  32
ASN A  35
None
0.75A7.54